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Segment Reporting - Summary of Revenue Significant Expenses and Net Loss for Segment (Details) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2024 | Dec. 31, 2023
Segment Reporting Information [Line Items] |  |
Collaboration revenue | $ 1,534 | $ 1,558
Research and development costs | 43,766 | 48,029
Impairment of property and equipment | 1,883 | 1,592
Impairment of right-of-use assets | 22,836 |
Restructuring and other related charges | 10,896 |
Total operating expenses | 97,882 | 68,678
Loss from operations | (96,348) | (67,120)
Interest income | 2,952 | 4,499
Total other income | 2,952 | 4,499
Loss before income tax expense | (93,396) | (62,621)
Income tax expense | (39) | (59)
Net loss | (93,435) | (62,680)
Clinical Related Costs |  |
Segment Reporting Information [Line Items] |  |
Research and development costs | 15,156 | 20,682
Employee Related Costs |  |
Segment Reporting Information [Line Items] |  |
Research and development costs | 22,828 | 27,124
Product Development and Manufacturing Costs |  |
Segment Reporting Information [Line Items] |  |
Research and development costs | 3,304 | 4,326
Facilities, Support Costs and Depreciation |  |
Segment Reporting Information [Line Items] |  |
Research and development costs | 13,579 | 7,425
Professional, Consulting and Public Company Costs |  |
Segment Reporting Information [Line Items] |  |
Research and development costs | $ 7,400 | 7,663
Legal Settlement |  |
Segment Reporting Information [Line Items] |  |
Research and development costs |  | (568)
Financing Costs |  |
Segment Reporting Information [Line Items] |  |
Research and development costs |  | $ 434

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