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Segment Reporting | 6 Months Ended
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Jun. 30, 2025
Segment Reporting [Abstract] |
Segment Reporting | 7. Segment Reporting Operating segments are defined as components of an enterprise about which separate discrete information is available for evaluation by the chief operating decision-maker (“CODM”) in deciding how to allocate resources and assess performance. The Company and the Company’s CODM, its chief executive officer, regularly review the Company’s operations and manage its business as a single operating segment, which is the business of developing targeted medicines to address ear, nose, and throat, or ENT, diseases. Segment revenues represent collaboration revenue from the Company’s consolidated statements of operations and is received from a single customer. Significant segment expenses consist primarily of employee-related costs, clinical, facility and professional and consulting costs in connection with preclinical and clinical development activities. Segment expenses also include impairment charges, when and as applicable. The Company’s CODM evaluates and allocates resources within the segment based on the Company’s net loss. As the Company is a clinical-stage biotechnology company, the evaluation includes review of the actual and budget costs related to employee-related costs, clinical trials, facility, professional and consulting costs in connection with preclinical and clinical development activities, and the conduct of these pre-clinical and clinical trials and responses from government agencies in determining the probability of success of product candidates. Total segment assets are reported in the Company’s condensed consolidated balance sheets as total assets. The following table presents revenue, significant expenses and net loss for the Company's segment (in thousands):
|  | Three Months Ended June 30, |  |  | Six Months Ended June 30, |
|  | 2025 |  |  | 2024 |  |  | 2025 |  |  | 2024 |
Collaboration revenue |  | $ | 183 |  |  | $ | 598 |  |  | $ | 366 |  |  | $ | 1,130 |
Operating expenses: |  |  |  |  |  |  |  |  |  |  |  |
Clinical related costs |  |  | 1,346 |  |  |  | 5,058 |  |  |  | 2,632 |  |  |  | 11,019 |
Employee related costs |  |  | 3,074 |  |  |  | 5,451 |  |  |  | 6,149 |  |  |  | 14,926 |
Product development and manufacturing costs |  |  | 176 |  |  |  | 1,415 |  |  |  | 309 |  |  |  | 2,898 |
Facilities, support costs and depreciation |  |  | 2,669 |  |  |  | 3,708 |  |  |  | 5,341 |  |  |  | 7,773 |
Professional, consulting and public company costs |  |  | 1,346 |  |  |  | 2,771 |  |  |  | 2,319 |  |  |  | 5,843 |
Impairment of property and equipment |  |  | — |  |  |  | 1,883 |  |  |  | — |  |  |  | 1,883 |
Impairment of right-of-use assets |  |  | — |  |  |  | 22,836 |  |  |  | — |  |  |  | 22,836 |
Restructuring and other related charges |  |  | 398 |  |  |  | 6,450 |  |  |  | 1,283 |  |  |  | 6,450 |
Total operating expenses |  |  | 9,009 |  |  |  | 49,572 |  |  |  | 18,033 |  |  |  | 73,628 |
Loss from operations |  |  | (8,826 | ) |  |  | (48,974 | ) |  |  | (17,667 | ) |  |  | (72,498 | )
Other income: |  |  |  |  |  |  |  |  |  |  |  |
Interest income |  |  | 410 |  |  |  | 855 |  |  |  | 708 |  |  |  | 1,941 |
Other income: |  |  | 981 |  |  |  | — |  |  |  | 981 |  |  |  | — |
Total other income |  |  | 1,391 |  |  |  | 855 |  |  |  | 1,689 |  |  |  | 1,941 |
Loss before income tax expense |  |  | (7,435 | ) |  |  | (48,119 | ) |  |  | (15,978 | ) |  |  | (70,557 | )
Income tax expense |  |  | (2 | ) |  |  | (12 | ) |  |  | (6 | ) |  |  | (26 | )
Net loss |  | $ | (7,437 | ) |  | $ | (48,131 | ) |  | $ | (15,984 | ) |  | $ | (70,583 | )

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- Definition The entire disclosure for reporting segments including data and tables. Reportable segments include those that meet any of the following quantitative thresholds a) it's reported revenue, including sales to external customers and intersegment sales or transfers is 10 percent or more of the combined revenue, internal and external, of all operating segments b) the absolute amount of its reported profit or loss is 10 percent or more of the greater, in absolute amount of 1) the combined reported profit of all operating segments that did not report a loss or 2) the combined reported loss of all operating segments that did report a loss c) its assets are 10 percent or more of the combined assets of all operating segments. + References Reference 1: http://www.xbrl.org/2003/role/exampleRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 55 -Paragraph 48 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482785/280-10-55-48 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 280 -SubTopic 10 -Name Accounting Standards 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