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Segment Reporting - Summary of Revenue Significant Expenses and Net Loss for Segment (Details) - USD ($) | 3 Months Ended | 6 Months Ended | 12 Months Ended | 15 Months Ended
--- | --- | --- | --- | ---
Jun. 30, 2025 | Mar. 31, 2025 | Jun. 30, 2024 | Mar. 31, 2024 | Jun. 30, 2025 | Jun. 30, 2024 | Dec. 31, 2024 | Dec. 31, 2023 | Jun. 30, 2025
Segment Reporting Information [Line Items] |  |  |  |  |  |  |  |  |
Collaboration revenue | $ 183,000 |  | $ 598,000 |  | $ 366,000 | $ 1,130,000 |  |  |
Research and development costs | 5,110,000 |  | 13,264,000 |  | 9,986,000 | 31,502,000 |  |  |
Impairment of property and equipment | 0 |  | 1,883,000 |  | 0 | 1,883,000 | $ 1,900,000 | $ 1,600,000 |
Impairment of right-of-use assets | 0 |  | 22,836,000 |  | 0 | 22,836,000 | 22,800,000 |  |
Restructuring and other related charges | 398,000 |  | 6,450,000 |  | 1,283,000 | 6,450,000 | $ 10,900,000 |  | $ 12,200,000
Total operating expenses | 9,009,000 |  | 49,572,000 |  | 18,033,000 | 73,628,000 |  |  |
Loss from operations | (8,826,000) |  | (48,974,000) |  | (17,667,000) | (72,498,000) |  |  |
Interest income | 410,000 |  | 855,000 |  | 708,000 | 1,941,000 |  |  |
Other income: | 981,000 |  | 0 |  | 981,000 | 0 |  |  |
Total other income | 1,391,000 |  | 855,000 |  | 1,689,000 | 1,941,000 |  |  |
Loss before income tax expense | (7,435,000) |  | (48,119,000) |  | (15,978,000) | (70,557,000) |  |  |
Income tax expense | (2,000) |  | (12,000) |  | (6,000) | (26,000) |  |  |
Net Income (Loss) | (7,437,000) | $ (8,547,000) | (48,131,000) | $ (22,452,000) | (15,984,000) | (70,583,000) |  |  |
Clinical Related Costs |  |  |  |  |  |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |  |  |  |  |  |
Research and development costs | 1,346,000 |  | 5,058,000 |  | 2,632,000 | 11,019,000 |  |  |
Employee Related Costs |  |  |  |  |  |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |  |  |  |  |  |
Research and development costs | 3,074,000 |  | 5,451,000 |  | 6,149,000 | 14,926,000 |  |  |
Product Development and Manufacturing Costs |  |  |  |  |  |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |  |  |  |  |  |
Research and development costs | 176,000 |  | 1,415,000 |  | 309,000 | 2,898,000 |  |  |
Facilities, Support Costs and Depreciation |  |  |  |  |  |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |  |  |  |  |  |
Research and development costs | 2,669,000 |  | 3,708,000 |  | 5,341,000 | 7,773,000 |  |  |
Professional, Consulting and Public Company Costs |  |  |  |  |  |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |  |  |  |  |  |
Research and development costs | $ 1,346,000 |  | $ 2,771,000 |  | $ 2,319,000 | $ 5,843,000 |  |  |

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