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Condensed Consolidated Statements of Operations and Comprehensive Loss (unaudited) - USD ($)
 3 Months Ended 9 Months Ended
Sep. 30, 2025
Sep. 30, 2024
Sep. 30, 2025
Sep. 30, 2024
Income Statement [Abstract]        
Collaboration revenue $ 25,000 $ 195,000 $ 391,000 $ 1,325,000
Operating expenses:        
Research and development 4,047,000 5,902,000 14,033,000 37,404,000
General and administrative 2,236,000 3,931,000 9,000,000 14,888,000
Impairment of property and equipment 0 0 0 1,883,000
Impairment of right-of-use assets 0 0 0 22,836,000
Restructuring and other related charges (21,000) 2,804,000 1,262,000 9,254,000
Total operating expenses 6,262,000 12,637,000 24,295,000 86,265,000
Loss from operations (6,237,000) (12,442,000) (23,904,000) (84,940,000)
Other income:        
Interest income 256,000 576,000 964,000 2,517,000
Other income 0 0 981,000 0
Total other income 256,000 576,000 1,945,000 2,517,000
Loss before income tax expense (5,981,000) (11,866,000) (21,959,000) (82,423,000)
Income tax expense (3,000) (7,000) (9,000) (33,000)
Net loss (5,984,000) (11,873,000) (21,968,000) (82,456,000)
Unrealized holding income (loss) on short-term investments, net of tax 0 24,000 0 (13,000)
Comprehensive loss $ (5,984,000) $ (11,849,000) $ (21,968,000) $ (82,469,000)
Net loss per share attributable to common stockholders- basic $ (3.38) $ (9.07) $ (14.85) $ (63.45)
Net loss per share attributable to common stockholders- diluted $ (3.38) $ (9.07) $ (14.85) $ (63.45)
Weighted-average common shares outstanding-basic 1,767,814 1,309,134 1,478,858 1,299,624
Weighted-average common shares outstanding-diluted 1,767,814 1,309,134 1,478,858 1,299,624