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Segment Reporting - Summary of Revenue Significant Expenses and Net Loss for Segment (Details) - USD ($)
 3 Months Ended 9 Months Ended 12 Months Ended 18 Months Ended
Sep. 30, 2025
Jun. 30, 2025
Mar. 31, 2025
Sep. 30, 2024
Jun. 30, 2024
Mar. 31, 2024
Sep. 30, 2025
Sep. 30, 2024
Dec. 31, 2024
Dec. 31, 2023
Sep. 30, 2025
Segment Reporting Information [Line Items]                      
Collaboration revenue $ 25,000     $ 195,000     $ 391,000 $ 1,325,000      
Research and development costs 4,047,000     5,902,000     14,033,000 37,404,000      
Impairment of property and equipment 0     0     0 1,883,000 $ 1,900,000 $ 1,600,000  
Impairment of right-of-use assets 0     0     0 22,836,000 22,800,000    
Restructuring and other related charges (21,000)     2,804,000     1,262,000 9,254,000 $ 10,900,000   $ 12,200,000
Total operating expenses 6,262,000     12,637,000     24,295,000 86,265,000      
Loss from operations (6,237,000)     (12,442,000)     (23,904,000) (84,940,000)      
Interest income 256,000     576,000     964,000 2,517,000      
Other income: 0     0     981,000 0      
Total other income 256,000     576,000     1,945,000 2,517,000      
Loss before income tax expense (5,981,000)     (11,866,000)     (21,959,000) (82,423,000)      
Income tax expense (3,000)     (7,000)     (9,000) (33,000)      
Net Income (Loss) (5,984,000) $ (7,437,000) $ (8,547,000) (11,873,000) $ (48,131,000) $ (22,452,000) (21,968,000) (82,456,000)      
Clinical Related Costs                      
Segment Reporting Information [Line Items]                      
Research and development costs 90,000     2,186,000     2,722,000 13,204,000      
Employee Related Costs                      
Segment Reporting Information [Line Items]                      
Research and development costs 2,069,000     3,738,000     8,218,000 18,665,000      
Product Development and Manufacturing Costs                      
Segment Reporting Information [Line Items]                      
Research and development costs 240,000     161,000     549,000 3,059,000      
Facilities, Support Costs and Depreciation                      
Segment Reporting Information [Line Items]                      
Research and development costs 2,639,000     2,915,000     7,980,000 10,688,000      
Professional, Consulting and Public Company Costs                      
Segment Reporting Information [Line Items]                      
Research and development costs $ 1,245,000     $ 833,000     $ 3,564,000 $ 6,676,000