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CONDENSED CONSOLIDATED STATEMENTS OF CONVERTIBLE PREFERRED STOCK AND STOCKHOLDERS' EQUITY (DEFICIT) (UNAUDITED) - USD ($) $ in Thousands | Total | Series A Convertible Preferred Stock | Series A-1 Convertible Preferred Stock [Member] | Series A-2 Convertible Preferred Stock | Series B Convertible Preferred Stock | Common Stock | Additional Paid-in Capital | Accumulated Deficit
--- | --- | --- | --- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2017 | $ (89,911) |  |  |  |  | $ 1 | $ 54,892 | $ (144,804)
Balance, shares at Dec. 31, 2017 |  | 7,471,765 | 1,586,024 | 1,183,703 | 1,665,291 |  |  |
Balance at Dec. 31, 2017 |  | $ 44,564 | $ 4,487 | $ 9,733 | $ 21,613 |  |  |
Balance, shares at Dec. 31, 2017 |  |  |  |  |  | 1,027,113 |  |
Issuance of common stock upon exercise of stock options | 11 |  |  |  |  |  | 11 |
Issuance of common stock upon exercise of stock options, shares |  |  |  |  |  | 8,457 |  |
Employee and nonemployee stock-based compensation | 33 |  |  |  |  |  | 33 |
Net loss | (5,071) |  |  |  |  |  |  | (5,071)
Balance at Mar. 31, 2018 | (94,938) |  |  |  |  | $ 1 | 54,936 | (149,875)
Balance, shares at Mar. 31, 2018 |  | 7,471,765 | 1,586,024 | 1,183,703 | 1,665,291 |  |  |
Balance at Mar. 31, 2018 |  | $ 44,564 | $ 4,487 | $ 9,733 | $ 21,613 |  |  |
Balance, shares at Mar. 31, 2018 |  |  |  |  |  | 1,035,570 |  |
Balance at Dec. 31, 2017 | (89,911) |  |  |  |  | $ 1 | 54,892 | (144,804)
Balance, shares at Dec. 31, 2017 |  | 7,471,765 | 1,586,024 | 1,183,703 | 1,665,291 |  |  |
Balance at Dec. 31, 2017 |  | $ 44,564 | $ 4,487 | $ 9,733 | $ 21,613 |  |  |
Balance, shares at Dec. 31, 2017 |  |  |  |  |  | 1,027,113 |  |
Balance at Dec. 31, 2018 | 5,129 |  |  |  |  | $ 15 | 148,641 | (143,527)
Balance, shares at Dec. 31, 2018 |  | 0 | 0 | 0 | 0 |  |  |
Balance at Dec. 31, 2018 |  | $ 0 | $ 0 | $ 0 | $ 0 |  |  |
Balance, shares at Dec. 31, 2018 |  |  |  |  |  | 15,591,357 |  |
Issuance of common stock, net of issuance costs | 1,604 |  |  |  |  | $ 1 | 1,603 |
Issuance of common stock, net of issuance costs, shares |  |  |  |  |  | 227,628 |  |
Issuance of common stock upon exercise of stock options | $ 41 |  |  |  |  |  | 41 |
Issuance of common stock upon exercise of stock options, shares | 54,720 |  |  |  |  | 54,720 |  |
Employee and nonemployee stock-based compensation | $ 47 |  |  |  |  |  | 47 |
Net loss | (6,206) |  |  |  |  |  |  | (6,206)
Balance at Mar. 31, 2019 | $ 615 |  |  |  |  | $ 16 | $ 150,332 | $ (149,733)
Balance, shares at Mar. 31, 2019 |  | 0 | 0 | 0 | 0 |  |  |
Balance at Mar. 31, 2019 |  | $ 0 | $ 0 | $ 0 | $ 0 |  |  |
Balance, shares at Mar. 31, 2019 |  |  |  |  |  | 15,873,705 |  |

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