    <SEC-DOCUMENT>0001213900-21-002942-index.html : 20210120
    <SEC-HEADER>0001213900-21-002942.hdr.sgml : 20210120
    <ACCEPTANCE-DATETIME>20210119173326
    ACCESSION NUMBER:		0001213900-21-002942
    CONFORMED SUBMISSION TYPE:	F-1/A
    PUBLIC DOCUMENT COUNT:		25
    FILED AS OF DATE:		20210120
    DATE AS OF CHANGE:		20210119

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			NLS Pharmaceutics Ltd.
    		CENTRAL INDEX KEY:			0001783036
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				000000000
    		STATE OF INCORPORATION:			V8
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		F-1/A
    		SEC ACT:		1933 Act
    		SEC FILE NUMBER:	333-236797
    		FILM NUMBER:		21536592

    	BUSINESS ADDRESS:
    		STREET 1:		ALTER POSTPLATZ 2
    		CITY:			STANS
    		STATE:			V8
    		ZIP:			CH-6370
    		BUSINESS PHONE:		41-79-779-60-00

    	MAIL ADDRESS:
    		STREET 1:		ALTER POSTPLATZ 2
    		CITY:			STANS
    		STATE:			V8
    		ZIP:			CH-6370
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>F-1/A
    <SEQUENCE>1
    <FILENAME>ea133431-f1a5_nlspharma.htm
    <DESCRIPTION>AMENDMENT NO. 5 TO FORM F-1
    <TEXT>
    Document 1 - file: ea133431-f1a5_nlspharma.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-1.1
    <SEQUENCE>2
    <FILENAME>ea133431ex1-1_nlspharma.htm
    <DESCRIPTION>FORM OF UNDERWRITING AGREEMENT BY AND AMONG NLS PHARMACEUTICS LTD. AND THE UNDERWRITERS NAMED THEREIN
    <TEXT>
    Document 2 - file: ea133431ex1-1_nlspharma.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.29
    <SEQUENCE>3
    <FILENAME>ea133431ex10-29_nlspharma.htm
    <DESCRIPTION>AMENDMENT NUMBER 4 TO CONVERTIBLE LOAN AGREEMENT DATED FEBRUARY 21, 2020 BETWEEN NLS PHARMACEUTICS LTD. AND ALEXANDER ZWYER
    <TEXT>
    Document 3 - file: ea133431ex10-29_nlspharma.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.30
    <SEQUENCE>4
    <FILENAME>ea133431ex10-30_nlspharma.htm
    <DESCRIPTION>AMENDMENT NUMBER 2 TO BRIDGE LOAN AGREEMENT BETWEEN NLS PHARMACEUTICS LTD. AND MAGNETIC ROCK INVESTMENT AG
    <TEXT>
    Document 4 - file: ea133431ex10-30_nlspharma.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.31
    <SEQUENCE>5
    <FILENAME>ea133431ex10-31_nlspharma.htm
    <DESCRIPTION>AMENDMENT NUMBER 3 TO BRIDGE LOAN AGREEMENT BETWEEN NLS PHARMACEUTICS LTD. AND MAGNETIC ROCK INVESTMENT AG
    <TEXT>
    Document 5 - file: ea133431ex10-31_nlspharma.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.32
    <SEQUENCE>6
    <FILENAME>ea133431ex10-32_nlspharma.htm
    <DESCRIPTION>FORM OF ADDENDUM NUMBER 4 TO PROMISSORY NOTE DATED JANUARY 2019 BETWEEN CERTAIN INVESTORS AND THE COMPANY
    <TEXT>
    Document 6 - file: ea133431ex10-32_nlspharma.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.33
    <SEQUENCE>7
    <FILENAME>ea133431ex10-33_nlspharma.htm
    <DESCRIPTION>ADDENDUM NUMBER 4 TO CREDIT FACILITY DATED AUGUST 31, 2015 BETWEEN NLS PHARMA AG AND THE LENDERS NAMED THEREIN
    <TEXT>
    Document 7 - file: ea133431ex10-33_nlspharma.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.34
    <SEQUENCE>8
    <FILENAME>ea133431ex10-34_nlspharma.htm
    <DESCRIPTION>ADDENDUM NUMBER 4 TO CREDIT FACILITY DATED AUGUST 31, 2015 BETWEEN NLS-1 PHARMA AG AND THE LENDERS NAMED THEREIN
    <TEXT>
    Document 8 - file: ea133431ex10-34_nlspharma.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.35
    <SEQUENCE>9
    <FILENAME>ea133431ex10-35_nlspharma.htm
    <DESCRIPTION>ADDENDUM NUMBER 4 TO CONVERTIBLE PROMISSORY NOTE DATED JANUARY 18, 2019 BETWEEN MAGNETIC ROCK INVESTMENT AG AND THE COMPANY
    <TEXT>
    Document 9 - file: ea133431ex10-35_nlspharma.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-23.1
    <SEQUENCE>10
    <FILENAME>ea133431ex23-1_nlspharma.htm
    <DESCRIPTION>CONSENT OF MARCUM LLP
    <TEXT>
    Document 10 - file: ea133431ex23-1_nlspharma.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-99.3
    <SEQUENCE>11
    <FILENAME>ea133431ex99-3_nlspharma.htm
    <DESCRIPTION>REGISTRANT'S REPRESENTATION PURSUANT TO REQUIREMENTS OF FORM 20-F, ITEM 8.A.4
    <TEXT>
    Document 11 - file: ea133431ex99-3_nlspharma.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>12
    <FILENAME>image_001.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 12 - file: image_001.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>13
    <FILENAME>image_004a.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 13 - file: image_004a.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>14
    <FILENAME>image_005.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 14 - file: image_005.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>15
    <FILENAME>image_006.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 15 - file: image_006.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>16
    <FILENAME>image_007.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 16 - file: image_007.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>17
    <FILENAME>image_008.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 17 - file: image_008.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>18
    <FILENAME>image_009.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 18 - file: image_009.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>19
    <FILENAME>image_010.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 19 - file: image_010.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>20
    <FILENAME>image_011.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 20 - file: image_011.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>21
    <FILENAME>image_012.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 21 - file: image_012.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>22
    <FILENAME>image_013.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 22 - file: image_013.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>23
    <FILENAME>image_014.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 23 - file: image_014.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>24
    <FILENAME>image_015.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 24 - file: image_015.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>25
    <FILENAME>image_016.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 25 - file: image_016.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>