    <SEC-DOCUMENT>0001493152-21-026319-index.html : 20211026
    <SEC-HEADER>0001493152-21-026319.hdr.sgml : 20211026
    <ACCEPTANCE-DATETIME>20211026142821
    ACCESSION NUMBER:		0001493152-21-026319
    CONFORMED SUBMISSION TYPE:	S-1/A
    PUBLIC DOCUMENT COUNT:		12
    FILED AS OF DATE:		20211026
    DATE AS OF CHANGE:		20211026

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Biofrontera Inc.
    		CENTRAL INDEX KEY:			0001858685
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				473765675
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		S-1/A
    		SEC ACT:		1933 Act
    		SEC FILE NUMBER:	333-257722
    		FILM NUMBER:		211347729

    	BUSINESS ADDRESS:
    		STREET 1:		120 PRESIDENTIAL WAY,
    		STREET 2:		SUITE 330
    		CITY:			WOBURN
    		STATE:			MA
    		ZIP:			01801
    		BUSINESS PHONE:		781-245-1325

    	MAIL ADDRESS:
    		STREET 1:		120 PRESIDENTIAL WAY,
    		STREET 2:		SUITE 330
    		CITY:			WOBURN
    		STATE:			MA
    		ZIP:			01801
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>S-1/A
    <SEQUENCE>1
    <FILENAME>forms-1a.htm
    <TEXT>
    Document 1 - file: forms-1a.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-1.1
    <SEQUENCE>2
    <FILENAME>ex1-1.htm
    <TEXT>
    Document 2 - file: ex1-1.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-4.3
    <SEQUENCE>3
    <FILENAME>ex4-3.htm
    <TEXT>
    Document 3 - file: ex4-3.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-5.1
    <SEQUENCE>4
    <FILENAME>ex5-1.htm
    <TEXT>
    Document 4 - file: ex5-1.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-23.1
    <SEQUENCE>5
    <FILENAME>ex23-1.htm
    <TEXT>
    Document 5 - file: ex23-1.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>6
    <FILENAME>forms-1_001.jpg
    <TEXT>
    Document 6 - file: forms-1_001.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>7
    <FILENAME>forms-1_1.jpg
    <TEXT>
    Document 7 - file: forms-1_1.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>8
    <FILENAME>forms-1a_002.jpg
    <TEXT>
    Document 8 - file: forms-1a_002.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>9
    <FILENAME>forms-1a_003.jpg
    <TEXT>
    Document 9 - file: forms-1a_003.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>10
    <FILENAME>forms-1a_004.jpg
    <TEXT>
    Document 10 - file: forms-1a_004.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>11
    <FILENAME>forms-1a_005.jpg
    <TEXT>
    Document 11 - file: forms-1a_005.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>12
    <FILENAME>ex5-1_001.jpg
    <TEXT>
    Document 12 - file: ex5-1_001.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>