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    <element id="BFRI_StartupCostFinancingTerm" name="StartupCostFinancingTerm" nillable="true" xbrli:periodType="duration" type="xbrli:durationItemType" substitutionGroup="xbrli:item" />
    <element id="BFRI_StartupCostFinancingMaturityDate" name="StartupCostFinancingMaturityDate" nillable="true" xbrli:periodType="duration" type="xbrli:dateItemType" substitutionGroup="xbrli:item" />
    <element id="BFRI_FairValueWarrantLiabilityPurchaseWarrant" name="FairValueWarrantLiabilityPurchaseWarrant" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="BFRI_RevenueFromContractWithCustomerAllowancesAndReserves" name="RevenueFromContractWithCustomerAllowancesAndReserves" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="BFRI_RevenueFromContractWithCustomerAllowancesAndReservesProvisionRelatedToCurrentPeriod" name="RevenueFromContractWithCustomerAllowancesAndReservesProvisionRelatedToCurrentPeriod" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="BFRI_RevenueFromContractWithCustomerAllowancesAndReservesCreditPaymentsMadeDuringPeriod" name="RevenueFromContractWithCustomerAllowancesAndReservesCreditPaymentsMadeDuringPeriod" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="BFRI_ReceivableForCommonStockWarrantsProceeds" name="ReceivableForCommonStockWarrantsProceeds" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="BFRI_LegalSettlementExpenses" name="LegalSettlementExpenses" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="BFRI_AccruedProductRevenueAllowancesAndReserves" name="AccruedProductRevenueAllowancesAndReserves" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="BFRI_OtherLiabilityNoncurrent" name="OtherLiabilityNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="BFRI_TransferPricePerUnitIncrementPercentage" name="TransferPricePerUnitIncrementPercentage" nillable="true" xbrli:periodType="instant" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="BFRI_PurchasePricePerUnitPercentage" name="PurchasePricePerUnitPercentage" nillable="true" xbrli:periodType="instant" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="BFRI_LegalSettlementsReceivablePercentage" name="LegalSettlementsReceivablePercentage" nillable="true" xbrli:periodType="instant" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="BFRI_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm1" name="SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm1" nillable="true" xbrli:periodType="duration" type="xbrli:durationItemType" substitutionGroup="xbrli:item" />
    <element id="BFRI_GrantDateFairValueOfShareBasedCompensationAwardedDuringPeriod" name="GrantDateFairValueOfShareBasedCompensationAwardedDuringPeriod" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="BFRI_ContractAssetInterestExpense" name="ContractAssetInterestExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="BFRI_ReimbursedCosts" name="ReimbursedCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="BFRI_OtherNonoperatingIncomeNet" name="OtherNonoperatingIncomeNet" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="BFRI_StockOptionsAndRestrictedStockUnits" name="StockOptionsAndRestrictedStockUnits" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="BFRI_LegalSettlementLiability" name="LegalSettlementLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="BFRI_CostOfRevenuesOther" name="CostOfRevenuesOther" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="BFRI_AmountOfInterestExpenseIncurredOnContractualAssetObtainedInBusinessAcquisition" name="AmountOfInterestExpenseIncurredOnContractualAssetObtainedInBusinessAcquisition" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="BFRI_ShorttermAcquisitionContractLiabilitiesAbstract" name="ShorttermAcquisitionContractLiabilitiesAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="BFRI_LongtermAcquisitionContractLiabilitiesAbstract" name="LongtermAcquisitionContractLiabilitiesAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="BFRI_InterestExpenses" name="InterestExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
</schema>
