20-F 1 d92594d20f.htm FORM 20-F

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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

FORM 20-F

(Mark One)

☐ | REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934

OR

☒ | ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the fiscal year ended June 30, 2020

OR

☐ | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

OR

☐ | SHELL COMPANY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

Date of event requiring this shell company report

For the transition period from to

Commission file number 0-29962

Kazia Therapeutics Limited

ACN 063 259 754

(Exact name of Registrant as specified in its charter)

Not Applicable

(Translation of Registrant’s name into English)

New South Wales, Australia

(Jurisdiction of incorporation or organization)

Three International Towers Level 24, 300 Barangaroo Avenue, Sydney, New South Wales 2000, Australia

(Address of principal executive offices)

Gabrielle Heaton

(e)Gabrielle.Heaton@kaziatherapeutics.com (t) +61-2-9472-4101

Three International Towers Level 24, 300 Barangaroo Avenue, Sydney, New South Wales 2000, Australia

(Name, Telephone, E-mail and/or Facsimile number and Address of Company Contact Person)

Securities registered or to be registered pursuant to Section 12(b) of the Act.

Title of each class |  | Trading Symbol(s) |  | Name of each exchange on which registered
American Depositary Shares, each representing ten Ordinary Shares* |  | KZIA |  | The NASDAQ Stock Market

Securities registered or to be registered pursuant to Section 12(g) of the Act.

None

* | Not for trading, but only in connection with the registration of American Depositary Shares.

Securities for which there is a reporting obligation pursuant to Section 15(d) of the Act.

Not Applicable

Indicate the number of outstanding shares of each of the issuer’s classes of capital or common stock as of the close of the period covered by the annual report.

The number of outstanding Ordinary Shares of the issuer as at June 30, 2020, was 94,598,369.

Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act.

Yes ☐ No ☒

If this report is an annual or transition report, indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934.

Yes ☐ No ☒

Note – Checking the box above will not relieve any registrant required to file reports pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 from their obligations under those Sections.

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.

Yes ☒ No ☐

Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files).

Yes ☒ No ☐

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or an emerging growth company. See definition of “large accelerated filer”, “accelerated filer”, and “emerging growth company” in Rule 12b-2 of the Exchange Act:

Large accelerated filer ☐ Accelerated filer ☐ Non-accelerated filer ☒ Emerging growth company ☒

If an emerging growth company that prepares its financial statements in accordance with U.S. GAAP, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Indicate by check mark which basis of accounting the registrant has used to prepare the financial statements included in this filing

U.S. GAAP ☐ |  | International Financial Reporting Standards as issued by the International Accounting Standards Board ☒ |  | Other ☐

If ‘Other’ has been checked in response to the previous question, indicate by check mark which financial statement item the registrant has elected to follow.

Item 17 ☐ Item 18 ☐

If this is an annual report, indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).

Yes ☐ No ☒

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TABLE OF CONTENTS

FORWARD-LOOKING STATEMENTS |  |  | 1 |
PART I |  |  |  |  | 1 |
Item 1. |  | Identity of Directors, Senior Management and Advisors |  |  | 1 |
Item 2. |  | Offer Statistics and Expected Timetable |  |  | 1 |
Item 3. |  | Key Information |  |  | 1 |
Item 4. |  | Information on the Company |  |  | 14 |
Item 4A. |  | Unresolved Staff Comments |  |  | 21 |
Item 5. |  | Operating and Financial Review and Prospects |  |  | 22 |
Item 6. |  | Directors, Senior Management and Employees |  |  | 27 |
Item 7. |  | Major Shareholders and Related Party Transactions |  |  | 37 |
Item 8. |  | Financial Information |  |  | 37 |
Item 9. |  | The Offer and Listing |  |  | 38 |
Item 10. |  | Additional Information |  |  | 38 |
Item 11. |  | Quantitative and Qualitative Disclosures about Market Risk |  |  | 49 |
Item 12. |  | Description of Securities Other than Equity Securities |  |  | 49 |
PART II |  |  | 51 |
Item 13. |  | Defaults, Dividend Arrearages and Delinquencies |  |  | 51 |
Item 14. |  | Material Modifications to the Rights of Security Holders and the Use of Proceeds |  |  | 51 |
Item 15. |  | Controls and Procedures |  |  | 51 |
Item 16. |  | [Reserved] |  |  | 51 |
Item 16A. |  | Audit Committee Financial Expert |  |  | 51 |
Item 16B. |  | Code of Ethics |  |  | 52 |
Item 16C. |  | Principal Accounting Fees and Services |  |  | 52 |
Item 16D. |  | Exemptions from the Listing Standards for Audit Committees |  |  | 52 |
Item 16E. |  | Purchases of Equity Securities by the Issuer and Affiliated Purchasers |  |  | 52 |
Item 16F. |  | Changes in registrant’s Certifying Accountant |  |  | 52 |
Item 16G. |  | Corporate Governance |  |  | 53 |
Item 16H. |  | Mine Safety Disclosure |  |  | 53 |
PART III |  |  | 54 |
Item 17. |  | Financial Statements |  |  | 54 |
Item 18. |  | Financial Statements |  |  | 54 |
Item 19. |  | Exhibits |  |  | 54 |

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FORWARD-LOOKING STATEMENTS

This Annual Report on Form 20-F includes forward-looking statements, which involve a number of risks and uncertainties. These forward-looking statements can generally be identified as such because the context of the statement will include words such as “may,” “will,” “intend,” “plan,” “believe,” “anticipate,” “expect,” “estimate,” “predict,” “potential,” “continue,” “likely,” or “opportunity,” the negative of these words or other similar words. Similarly, statements that describe our future plans, strategies, intentions, expectations, objectives, goals or prospects and other statements that are not historical facts are also forward-looking statements. Discussions containing these forward-looking statements may be found, among other places, in “Business Overview” and “Operating and Financial Review and Prospects” in this Annual Report on Form 20-F. For such statements, we claim the protection of the Private Securities Litigation Reform Act of 1995 and section 27A of the Securities Act and Section 21E of the Exchange Act. Readers of this Annual Report on Form 20-F are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the time this Annual Report on Form 20-F was filed with the Securities and Exchange Commission, or SEC. These forward-looking statements are based largely on our expectations and projections about future events and future trends affecting our business and are subject to risks and uncertainties that could cause actual results to differ materially from those anticipated in the forward-looking statements. These risks and uncertainties include, without limitation, those discussed in “Risk Factors” and in “Operating and Financial Review and Prospects” of this Annual Report on Form 20-F. In addition, past financial or operating performance is not necessarily a reliable indicator of future performance, and you should not use our historical performance to anticipate results or future period trends. We can give no assurances that any of the events anticipated by the forward-looking statements will occur or, if any of them do, what impact they will have on our results of operations and financial condition. Except as required by law, we undertake no obligation to update publicly or revise our forward-looking statements to reflect events or circumstances that arise after the filing of this Annual Report on Form 20-F.

In this Annual Report on Form 20-F, “Kazia,” “Company,” “we,” “us” and “our” refer to Kazia Therapeutics Limited and its wholly owned subsidiaries on a consolidated basis, unless the context otherwise provides.

PART I

Item 1. | Identity of Directors, Senior Management and Advisors

Item 1 details are not required to be disclosed as part of the Annual Report.

Item 2. | Offer Statistics and Expected Timetable

Item 2 details are not required to be disclosed as part of the Annual Report.

Item 3. | Key Information

A. Selected financial data

The selected financial data have been derived from the consolidated financial statements of the Company as of June 30, 2020 and 2019 and for the fiscal years ended June 30, 2020, 2019 and 2018 included in this Annual Report. The selected financial data as of June 30, 2018, 2017 and 2016 and for the years ended June 30, 2017 and 2016 have been derived from the consolidated financial statements of the Company that are not included in this Annual Report. This data should be read in conjunction with, and are qualified in their entirety by, reference to those statements and the notes thereto.

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This financial report complies with International Financial Reporting Standards (“IFRS”) as issued by the International Accounting Standards Board (“IASB”). The consolidated financial statements have been audited in accordance with the Public Company Accounting Oversight Board (“PCAOB”) auditing standards in the United States by the Company’s independent registered public accounting firm. The Company’s fiscal year ends on June 30. As used throughout this Annual Report, the word “fiscal” followed by a year refers to the 12-month period ended on June 30 of that year. For example, the term “fiscal 2020” refers to the 12 months ended June 30, 2020. Except as otherwise indicated, all dollar amounts referred to in this Annual Report are at the consolidated level and exclude inter-company amounts.

Summary of consolidated profit or loss and other comprehensive income (IFRS) |  | 2016 A$’000 |  |  | 2017 A$’000 |  |  | 2018 A$’000 |  |  | 2019 A$’000 |  |  | 2020 A$’000 |
Revenue and other income |  |  | 4,071 |  |  |  | 8,812 |  |  |  | 13,108 |  |  |  | 1,565 |  |  |  | 1,061 |
Loss before income tax expense from continuing operations |  |  | (12,155 | ) |  |  | (10,869 | ) |  |  | (6,344 | ) |  |  | (10,568 | ) |  |  | (12,765 | )
Profit after income tax expense from discontinued operations |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
Loss after income tax expense for the year |  |  | (12,155 | ) |  |  | (10,670 | ) |  |  | (6,039 | ) |  |  | (10,270 | ) |  |  | (12,467 | )
Net (loss) attributable to members of Kazia Therapeutics Limited |  |  | (12,062 | ) |  |  | (10,670 | ) |  |  | (6,039 | ) |  |  | (10,270 | ) |  |  | (12,467 | )
Earnings (loss) per share from continuing operations attributable to the owners of Kazia Therapeutics Limited |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basic (loss) per share (cents per share) |  |  | (2.82 | ) |  |  | (2.28 | ) |  |  | (12.48 | ) |  |  | (17.86 | ) |  |  | (17.07 | )
Diluted (loss) per share (cents per share) |  |  | (2.82 | ) |  |  | (2.28 | ) |  |  | (12.48 | ) |  |  | (17.86 | ) |  |  | (17.07 | )
Weighted average number of ordinary share shares used to calculate earnings per share |  |  | 427,431,910 |  |  |  | 467,833,849 |  |  |  | 48,376,525 |  |  |  | 57,503,555 |  |  |  | 73,053,514 |
Number of outstanding ordinary shares at year end |  |  | 429,733,982 |  |  |  | 483,287,914 |  |  |  | 48,409,621 |  |  |  | 62,166,673 |  |  |  | 94,598,369 |

Summary of consolidated financial position (IFRS) |  | 2016 A$’000 |  |  | 2017 A$’000 |  |  | 2018 A$’000 |  |  | 2019 A$’000 |  |  | 2020 A$’000 |
Cash and cash equivalents |  |  | 33,453 |  |  |  | 14,455 |  |  |  | 5,956 |  |  |  | 5,434 |  |  |  | 8,764 |
Total assets |  |  | 35,517 |  |  |  | 35,910 |  |  |  | 28,175 |  |  |  | 21,177 |  |  |  | 23,063 |
Net assets/Equity |  |  | 33,931 |  |  |  | 25,338 |  |  |  | 19,242 |  |  |  | 14,195 |  |  |  | 14,125 |
Debt |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
Capital Stock |  |  | 191,301 |  |  |  | 193,769 |  |  |  | 31,576 |  |  |  | 36,642 |  |  |  | 48,781 |

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The Company publishes its consolidated financial statements expressed in Australian dollars. In this Annual Report, references to “U.S. dollars” or “US$” are to the currency of the United States of America (“U.S.”) and references to “Australian dollars”, “$” or “A$” are to the currency of Australia. For the convenience of the reader, this Annual Report contains translations of certain Australian dollar amounts into U.S. dollars at specified rates. These translations should not be construed as representations that the Australian dollar amounts actually represent such U.S. dollar amounts or could be converted into U.S. dollars at the rate indicated. Unless otherwise stated, the translations of Australian dollars into U.S. dollars have been made at the rate of US$0.6863 = A$1.00, the foreign exchange rate as issued weekly by the Board of Governors of the Federal Reserve System (www.federalreserve.gov/releases) on June 30, 2020.

B. Capitalization and Indebtedness.

Not applicable.

C. Reasons for the Offer and Use of Proceeds.

Not applicable.

D. Risk factors

Investment in our securities involves a high degree of risk. You should consider carefully the risks described below, together with other information in this Annual Report on Form 20-F and our other public filings, before making investment decisions regarding our securities. If any of the following events actually occur, our business, operating results, prospects or financial condition could be materially and adversely affected. This could cause the trading price of our common stock to decline and you may lose all or part of your investment. Moreover, the risks described below are not the only ones that we face. Additional risks not presently known to us or that we currently deem immaterial may also affect our business, operating results, prospects or financial condition.

Risks Related to Our Financial Condition and Capital Requirement

We have incurred significant net losses. We anticipate that we will continue to incur significant net losses for the foreseeable future and we may never achieve or maintain profitability.

We are a biotechnology company and have not yet generated significant revenue. We have incurred losses of A$6.0 million, A$10.3 million and A$12.5 million for the fiscal years ended June 30, 2018, 2019 and 2020, respectively. We have not generated any revenues from sales of any of our product candidates.

As of June 30, 2020, we had accumulated losses of A$36.2 million. We have devoted most of our financial resources to research and development, including our clinical and preclinical development activities. To date, we have financed our operations primarily through the issuance of equity securities, research and development grants from the Australian government and payments from our collaboration partners. We have not generated, and do not expect to generate, any significant revenue for the foreseeable future, and we expect to continue to incur significant operating losses for the foreseeable future due to the cost of research and development including clinical trials and the regulatory approval process for product candidates. The amount of our future net losses is uncertain and will depend, in part, on the rate of our future expenditures. Our ability to continue operations will depend on, among other things, our ability to obtain funding through equity or debt financings, strategic collaborations or grants.

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We expect to continue to incur significant expenses and similar or increasing operating losses for the foreseeable future. We anticipate that our expenses will increase substantially if and as we:

| • |  | continue our research and clinical development of our product candidates;

| • |  | expand the scope of our current clinical studies for our product candidates or initiate additional clinical or other studies for product candidates;

| • |  | seek regulatory and marketing approvals for any of our product candidates that successfully complete clinical trials;

| • |  | further develop the manufacturing process for our product candidates;

| • |  | change or add additional manufacturers or suppliers;

| • |  | seek to identify and validate additional product candidates;

| • |  | acquire or in-license other product candidates and technologies;

| • |  | maintain, protect and expand our intellectual property portfolio;

| • |  | create additional infrastructure to support our operations as a public company in the United States and our product development and future commercialization efforts; and

| • |  | experience any delays or encounter issues with any of the above.

The net losses we incur may fluctuate significantly from year to year, such that a period to-period comparison of our results of operations may not be a good indication of our future performance.

We have never generated any revenue from product sales and may never be profitable.

Our ability to generate significant revenue and achieve profitability depends on our ability, alone or with strategic collaboration partners, to successfully complete the development of and obtain the regulatory approvals for our product candidates, to manufacture sufficient supply of our product candidates, to establish a sales and marketing organization or suitable third-party alternative for the marketing of any approved products and to successfully commercialize any approved products on commercially reasonable terms. All of these activities will require us to raise sufficient funds to finance business activities. We do not expect any milestone payments from our collaborative partners to be significant in the foreseeable future. In addition, we do not anticipate generating revenue from commercializing product candidates for the foreseeable future, if ever. Our ability to generate future revenues from commercializing product candidates depends heavily on our success in:

| • |  | successfully initiating and completing clinical trials of our product candidates;

| • |  | obtaining regulatory and marketing approvals for product candidates for which we complete clinical trials;

| • |  | maintaining, protecting and expanding our intellectual property portfolio, and avoiding infringing on intellectual property of third parties;

| • |  | establishing and maintaining successful licenses, collaborations and alliances with third parties;

| • |  | developing a sustainable, scalable, reproducible and transferable manufacturing process for our product candidates;

| • |  | establishing and maintaining supply and manufacturing relationships with third parties that can provide products and services adequate, in amount and quality, to support clinical development and commercialization of our product candidates, if approved;

| • |  | launching and commercializing any product candidates for which we obtain regulatory and marketing approval, either by collaborating with a partner or, if launched independently, by establishing a sales, marketing and distribution infrastructure;

| • |  | obtaining market acceptance of any product candidates that receive regulatory approval as viable treatment options;

| • |  | obtaining favorable coverage and reimbursement rates for our products from third-party payers;

| • |  | addressing any competing technological and market developments;

| • |  | identifying and validating new product candidates; and

| • |  | negotiating favorable terms in any collaboration, licensing or other arrangements into which we may enter.

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Even if one or more of our product candidates is approved for commercial sale, we may incur significant costs associated with commercializing any approved product candidate. As one example, our expenses could increase beyond expectations if we are required by the Food and Drug Administration, or FDA, or other regulatory agencies, domestic or foreign, to perform clinical and other studies in addition to those that we currently anticipate. Even if we are able to generate revenues from the sale of any approved products, we may not become profitable and may need to obtain additional funding to continue operations, which could have an adverse effect on our business, financial condition, results of operations and prospects.

The Company is currently conducting clinical trials of two experimental therapies. Failure of one or both of these therapies to show benefit to patients could materially affect the continuity of our business and our financial condition.

The Company’s lead programs include paxalisib (formerly GDC-0084), a small molecule inhibitor of the PI3K/Akt/mTor pathway, and Cantrixil (TRX-E-002-1), a small molecule agent with activity against tumor-initiating cells. However, even though progress has been made, such as the clinical validation of the PI3K/Akt/mTor pathway as a target for oncology therapies, developments of our product candidates may prove unsuccessful, after completion of clinical trials, due to any failure to provide any beneficial effect to cancer patients. It is possible that either or both agents may fail to show sufficient benefit as a treatment for cancer to become commercially viable products.

The Company has ongoing clinical trials in which experimental therapies are administered to human subjects. If profound and unexpected safety concerns are encountered in clinical trials, it may materially affect the continuity of our business and our financial condition.

Despite all applicable efforts to characterise the safety profile of our drug development candidates through animal studies and other mechanisms, the possibility of unexpected safety concerns remains. If one or both of our clinical stage candidates were found to be associated with profound and unexpected toxicity, Kazia may be required to cease development, and may additionally incur other impairments to the business including reputational damage.

The Company’s ability to continue as a going concern is dependent on its ability to raise capital to support its R&D programs.

The Company has limited cash resources and will periodically need additional funds to maintain the planned level of R&D activity. We expect to consume cash and incur operating losses for the foreseeable future as the Company continues developing its oncology drug candidates. The impact on cash resources and results from operations will vary with the extent and timing of future clinical trial programs. While it is not possible to make accurate predictions of future operating results, we expect existing cash and cash equivalents will be sufficient to enable us to continue our research and development activities until approximately the first quarter of calendar 2022.

As at June 30, 2020, we had cash in hand and at bank of A$8.8 million and further readily realizable assets of A$1.0 million. The financial statements have been prepared on a going concern basis, which contemplates continuity of normal activities and realisation of assets and settlement of liabilities in the normal course of business. As is often the case with drug development companies, our ability to continue as a going concern is dependent upon our ability to derive sufficient cash from investors, from licensing and partnering activities and from other sources of revenue such as grant funding. The directors have considered the cash flow forecasts and the funding requirements of the business and are confident that the strategies in place are appropriate to generate sufficient funding to allow us to continue as a going concern.

If the Company is unable to obtain additional funds on favorable terms or at all, it may be required to cease or reduce its operations. Also, if the Company raises more funds by selling additional securities, the ownership interests of holders of its securities will be diluted.

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From time to time we receive Australian government research and development grants. If we lose funding from these research and development grants or fail to qualify for the R&D cash rebate, we may encounter difficulties in the funding of future research and development projects, which could harm our operating results.

We have historically received grants through the Australian federal government’s Research and Development Tax Incentive program (“R&D tax rebate”), under which the government provides a cash refund for a percentage of eligible research and development expenditures by small Australian entities (defined as Australian entities with less than A$20 million in revenue) having a tax loss. The R&D tax rebate is made by the Australian federal government for eligible research and development purposes based on the filing of an annual application. We received R&D tax rebates during fiscal 2019 and 2020 of A$1.4 million and A$1.0 million, respectively. In respect of fiscal 2020, we estimate the rebate which will be received in early fiscal 2020 and have accrued an amount of A$1.0 million as income in the statement of profit or loss and other comprehensive income. This rebate is available for our research and development activities in Australia, as well as activities in the United States and other countries to the extent such non-Australian based expenses relate to our activities in Australia, do not exceed 50% of the expenses for the relevant activities and are approved by the Australian government.

To the extent our research and development expenditures are deemed to be “ineligible,” then our rebates would decrease. In addition, the Australian government may in the future decide to modify the requirements of, reduce the amounts of the rebates available under, or discontinue the R&D tax rebate program.

Negative global economic conditions may pose challenges to the Company’s business strategy, which relies on access to capital from the markets or collaborators. Failure to obtain sufficient funding on acceptable terms could have a material adverse effect on our business, results of operations and financial condition.

Negative conditions in the global economy, including credit markets and the financial services industry, have generally made equity and debt financing more difficult to obtain, and may negatively impact the Company’s ability to complete financing transactions. For instance, the current COVID-19 global pandemic has negatively affected the global economy and has created uncertainties in the financial markets and volatility in stock markets, which increases the risk of capital raisings being unsuccessful for issuers that need funds to finance their business operations. The duration and severity of these conditions is uncertain, as is the extent to which they may adversely affect the Company’s business and the business of current and prospective vendors and collaborators. If negative global economic conditions persist or worsen, the Company may be unable to secure additional funding to sustain its operations or to find suitable collaborators to advance its internal programs, even if positive results are achieved from research and development efforts.

If we are unable to raise sufficient funding on acceptable terms, we may be unable to continue to operate. There is no assurance that we will be successful in obtaining sufficient financing on acceptable terms and conditions to fund continuing operations, if at all. Our failure to obtain sufficient funds on acceptable terms when needed could have a material adverse effect on our business, results of operations and financial condition.

Risks Related to Our Business Operations

We may not successfully engage in strategic transactions or enter into new collaborations, which could adversely affect our ability to develop and commercialize product candidates, impact our cash position, increase our expenses and present significant distractions to our management.

From time to time, we may consider additional strategic transactions, such as collaborations, acquisitions, asset purchases or sales and out- or in-licensing of product candidates or technologies. In particular we will evaluate and, if strategically attractive, seek to enter into additional collaborations, including with major biotechnology or pharmaceutical companies. The competition for collaborators is significant, and the negotiation process is time-consuming and complex. Any new collaboration may be on terms that are not optimal for us, and we may not be able to maintain any new or existing collaboration if, for example, development or approval of a product candidate is delayed, sales of an approved product candidate do not meet expectations or the collaborator discontinues the collaboration. Any such collaboration, or other strategic transaction, may require us to incur non-recurring or other charges, increase our expenditures, pose significant integration or implementation challenges or disrupt our management or business.

These transactions would entail numerous operational and financial risks, including exposure to unknown liabilities, incurrence of substantial debt or dilutive issuances of equity securities to pay transaction consideration or costs, higher than expected collaboration, acquisition or integration costs, write-downs of assets or goodwill or impairment charges, increased amortization expenses, difficulty and cost in facilitating the collaboration or combining the operations and personnel of any acquired business, impairment of relationships with key suppliers, manufacturers or customers of any acquired business due to changes in management and ownership and the inability to retain key employees of any acquired business.

Accordingly, although there can be no assurance that we will undertake or successfully complete any additional transactions of the nature described above, any transactions that we do complete may be subject to the foregoing or other risks and have a material adverse effect on our business, results of operations, financial condition and prospects. Conversely, any failure to enter any collaboration or other strategic transaction that would be beneficial to us could delay and make more expensive the development and potential commercialization of our product candidates and have a negative impact on the competitiveness of any product candidate that reaches market.

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Any inability to attract and retain qualified key management and technical personnel would impair our ability to implement our business plan.

Our success largely depends on the continued service of key management and other specialized personnel. The loss of one or more members of our management team or other key employees or advisors could delay or increase the cost of our research and development programs and materially harm our business, financial condition, results of operations and prospects. The relationships that our key managers have cultivated within our industry make us particularly dependent upon their continued employment with us. We are dependent on the continued service of our technical personnel because of the highly technical nature of our product candidates and the specialized nature of the regulatory approval process for our product candidates. Because our management team and key employees are not obligated to provide us with continued service, they could terminate their employment with us at any time without penalty. We do not maintain key person life insurance policies on any of our management team members or key employees. Our future success will depend in large part on our continued ability to attract and retain other highly qualified scientific, technical and management personnel, as well as personnel with expertise in clinical testing, manufacturing, governmental regulation and commercialization. We face competition for personnel from other companies, universities, public and private research institutions, government entities and other organizations.

Our collaborations with outside scientists and consultants may be subject to restriction and change.

We work with medical experts, chemists, biologists and other scientists at academic and other institutions, and consultants who assist us in our research, development and regulatory efforts, including the members of our scientific advisory board. In addition, these scientists and consultants have provided, and we expect that they will continue to provide, valuable advice regarding our programs and regulatory approval processes. These scientists and consultants are not our employees and may have other commitments that would limit their future availability to us. If a conflict of interest arises between their work for us and their work for another entity, we may lose their services. In addition, we are limited in our ability to prevent them from establishing competing businesses or developing competing products. For example, if a key scientist acting as a principal investigator in any of our future clinical trials identifies a potential product or compound that is more scientifically interesting to his or her professional interests, his or her availability to remain involved in any future clinical trials could be restricted or eliminated.

We face potential product liability, and, if successful claims are brought against us, we may incur substantial liability and costs. If the use of our product candidates harms patients, or is perceived to harm patients even when such harm is unrelated to our product candidates, our regulatory approvals could be revoked or otherwise negatively impacted and we could be subject to costly and damaging product liability claims.

The use of our product candidates in clinical trials and the sale of any products for which we may in the future obtain marketing approval exposes us to the risk of product liability claims. Product liability claims might be brought against us by consumers, healthcare providers, pharmaceutical companies or others selling or otherwise coming into contact with our product candidates. There is a risk that our product candidates may induce adverse events. If we cannot successfully defend against product liability claims, we could incur substantial liability and costs. In addition, regardless of merit or eventual outcome, product liability claims may result in:

| • |  | impairment of our business reputation;

| • |  | withdrawal of clinical trial participants;

| • |  | costs due to related litigation;

| • |  | distraction of management’s attention from our primary business;

| • |  | substantial monetary awards to patients or other claimants;

| • |  | the inability to commercialize our product candidates;

| • |  | decreased demand for our product candidates, if approved for commercial sale; and

| • |  | increased cost, or impairment of our ability, to obtain or maintain product liability insurance coverage.

We may use our limited financial and human resources to pursue a particular research program or product candidate and fail to capitalize on programs or product candidates that may be more profitable or for which there is a greater likelihood of success.

Because we have limited resources, we may forego or delay pursuit of opportunities with certain programs or product candidates or for indications that later prove to have greater commercial potential. Our resource allocation decisions may cause us to fail to capitalize on viable commercial products or profitable market opportunities. Our spending on current and future research and development programs for product candidates may not yield any commercially viable products. If we do not accurately evaluate the commercial potential or target market for a particular product candidate, we may relinquish valuable rights to that product candidate through strategic collaboration, licensing or other royalty arrangements in cases in which it would have been more advantageous for us to retain sole development and commercialization rights to such product candidate, or we may allocate internal resources to a product candidate in a therapeutic area in which it would have been more advantageous to enter into a collaboration arrangement.

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Our internal computer and information technology systems, or those of our collaborators and other development partners, third-party Contract Research Organisations (CROs) or other contractors or consultants, may fail or suffer security breaches, which could result in a disruption of our product development programs.

Despite the implementation of security measures, our internal computer and information technology systems and those of our current and any future CROs and other contractors, consultants and collaborators are vulnerable to damage from computer viruses, cyber-attacks, unauthorized access, natural disasters, terrorism, war and telecommunication and electrical failures. Such events could cause interruptions of our operations. While we have not experienced any material system failure, accident or security breach to date, if such an event were to occur and cause interruptions in our operations, it could result in a disruption of our development programs and our business operations, whether due to a loss of our trade secrets or other similar disruptions. For example, the loss of clinical trial data from ongoing or future clinical trials or data from preclinical studies could result in delays in our regulatory approval efforts and significantly increase our costs to recover or reproduce the data. Likewise, we rely on third parties to manufacture our product candidates and will rely on third parties to conduct future clinical trials, and similar events relating to their computer systems could also have similar consequences to our business. To the extent that any disruption or security breach were to result in a loss of, or damage to, our data or applications, or inappropriate disclosure of confidential or proprietary information, we could incur liability and the further development and commercialization of our product candidates could be delayed and become more expensive.

Our ability to utilize our net operating losses and certain other tax attributes may be limited.

We have substantial carried forward tax losses which may not be available to offset any future assessable income. In order for an Australian corporate taxpayer to carry forward and utilize tax losses, the taxpayer must pass either the continuity of ownership test, or, if it fails the COT, the same business test (“SBT”), or similar business test, in respect of relevant tax losses.

We have not carried out any analysis as to whether we have met the COT or, failing the COT, the SBT or similar business test over relevant periods. In addition, future shareholding changes may result in a significant ownership change for us. It is therefore uncertain as to whether any of our tax losses carried forward as of June 30, 2020 will be available to be carried forward and available to offset our assessable income, if any, in future periods.

Risks Related to the Product Development and Regulatory Approval of Our Product Candidates

We may not be able to obtain orphan drug exclusivity, where relevant, in all markets for our product candidates.

Regulatory authorities in some jurisdictions, including the United States, may designate drugs for relatively small patient populations as orphan drugs. Under the Orphan Drug Act, the FDA may designate a product as an orphan drug if it is a product intended to treat a rare disease or condition, which is generally defined as a patient population of fewer than 200,000 individuals annually in the United States. The FDA may also designate a product as an orphan drug if it is intended to treat a disease or condition of more than 200,000 individuals in the United States and there is no reasonable expectation that the cost of developing and making a drug or biological product available in the United States for this type of disease or condition will be recovered from sales of the product candidate.

Generally, if a product with an orphan drug designation subsequently receives the first marketing approval for the indication for which it has such designation, the product is entitled to a period of marketing exclusivity, which precludes the FDA from approving another marketing application for the same drug for such indication for that time period. The applicable period is seven years in the United States. Orphan drug exclusivity may be lost if the FDA determines that the request for designation was materially defective or if the manufacturer is unable to assure sufficient quantity of the drug to meet the needs of patients with the rare disease or condition.

In April 2015, the FDA granted orphan drug designation in the United States for Cantrixil (TRX-E-002-1), in February 2018, the FDA granted orphan drug designation status in the United States for paxalisib (formerly GDC-0084) for the treatment of glioblastoma, and in August 2020, the FDA granted orphan drug designation status in the United States for paxalisib (formerly GDC-0084) for the treatment of malignant glioma, which includes DIPG, a rare and highly aggressive childhood brain cancer. Even if we obtain orphan drug exclusivity for additional products in the United States or other jurisdictions, that exclusivity may not effectively protect the product from competition because different drugs can be approved for the same condition, and the same drug could be approved for a different condition. Moreover, even after an orphan drug is approved, the FDA can subsequently approve the same drug, made by a competitor, for the same condition if the FDA concludes that the competitive product is clinically superior in that it is shown to be safer, more effective or makes a major contribution to patient care.

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Positive results from preclinical studies of our product candidates are not necessarily predictive of the results of our planned clinical trials of our product candidates.

Positive results in preclinical proof of concept and animal studies of our product candidates may not result in positive results in clinical trials in humans. Many companies in the pharmaceutical and biotechnology industries have suffered significant setbacks in clinical trials after achieving positive results in preclinical development or early stage clinical trials, and we cannot be certain that we will not face similar setbacks. These setbacks have been caused by, among other things, preclinical findings made while clinical trials were underway or safety or efficacy observations made in clinical trials, including adverse events. Moreover, preclinical and clinical data are often susceptible to varying interpretations and analyses, and many companies that believed their product candidates performed satisfactorily in preclinical studies and clinical trials nonetheless failed to obtain FDA or other regulatory authority approval. If we fail to produce positive results in our clinical trials of our product candidates, the development timeline and regulatory approval and commercialization prospects for our product candidates, and, correspondingly, our business and financial prospects, would be negatively impacted.

Even if the Company receives regulatory approval to commercialize its drug candidates, the ability to generate revenues from any resulting products will be subject to a variety of risks, many of which are out of the Company’s control.

Regardless of regulatory approval, products arising from the development process may not gain market acceptance among physicians, patients, healthcare payers or the medical community. The Company believes that the degree of market acceptance and its ability to generate revenues from such products will depend on a number of factors, including, but not limited to:

| • |  | advancements in the treatment of cancer that make our treatments obsolete;

| • |  | market exclusivity and competitor products;

| • |  | timing of market introduction of the Company’s drugs and competitive drugs;

| • |  | actual and perceived efficacy and safety of the Company’s drug candidates;

| • |  | prevalence and severity of any side effects;

| • |  | potential or perceived advantages or disadvantages over alternative treatments;

| • |  | strength of sales, marketing and distribution support;

| • |  | price of future products, both in absolute terms and relative to alternative treatments;

| • |  | the effect of current and future healthcare laws on the Company’s drug candidates; and

| • |  | availability of coverage and reimbursement from government and other third-party payers.

If any of the Company’s drugs are approved and fail to achieve market acceptance, the Company may not be able to generate significant revenue to achieve or sustain profitability.

Risks Related to Commercialization of Our Product Candidates

The Company may not be able to establish the contractual arrangements necessary to develop, market and distribute the product candidates. Our failure to do so may adversely affect our business, results of operations and financial condition.

The Company has been successful in executing contractual agreements with strategic partners. This remains a key part of the Company’s business plan and the Company must continue to partner with third parties to manufacture clinical grade drug product and conduct key pre-clinical and clinical investigations. Strategic agreements around packaging, branding, market access and distribution for its drug products will also eventually be required.

However, potential partners could be discouraged by the Company’s limited operating history. There is no assurance that the Company will be able to negotiate commercially acceptable licensing or other agreements for the future exploitation of its drug product candidates including continued clinical development, manufacture or marketing. If the Company is unable to successfully contract for these services, or if arrangements for these services are terminated, the Company may have to delay the commercialization program which will adversely affect its ability to generate operating revenues.

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The Company’s commercial opportunity will be reduced or eliminated if competitors develop and market products that are more effective, have fewer side effects or are less expensive than its drug candidates.

The development of drug candidates is highly competitive and is high risk. A number of other companies have products or drug candidates in various stages of pre-clinical or clinical development that are intended for the same therapeutic indications for which the Company’s drug candidates are being developed. Some of these potential competing drugs are further advanced in development than the Company’s drug candidates and may be commercialized sooner. Even if the Company is successful in developing effective drugs, its compounds may not compete successfully with products produced by its competitors.

The Company’s competitors include pharmaceutical companies and biotechnology companies, as well as universities and public and private research institutions. In addition, companies active in different but related fields represent substantial competition. Many of the Company’s competitors developing oncology drugs have significantly greater capital resources, larger R&D staff and facilities and greater experience in drug development, regulation, manufacturing and marketing. These organizations also compete with the Company and its service providers, to recruit qualified personnel, and to attract partners for joint ventures and to license technologies. As a result, the Company’s competitors may be able to develop technologies and products that would render the Company’s technologies or its drug candidates obsolete or non-competitive.

Risks Related to Our Intellectual Property

If we are unable to protect intellectual property rights related to our product candidates, we may not be able to obtain exclusivity for our product candidates or prevent others from developing similar competitive products.

We rely upon a combination of patents, know-how, trade secret protection and confidentiality agreements to protect the intellectual property related to our product candidates.

The strength of patents in the biotechnology and pharmaceutical field involves complex legal and scientific questions and can be uncertain. The patent applications that we own or in-license may fail to result in issued patents with claims that cover our product candidates in the United States or other jurisdictions. In addition, we cannot guarantee that any patents will issue from any pending or future patent applications owned by or licensed to us. There is no assurance that all of the potentially relevant prior art relating to our patents and patent applications has been found. If such prior art exists, it can invalidate a patent or prevent a patent from issuing from a pending patent application. Even if patents do successfully issue and even if such patents cover our product candidates, third parties may initiate opposition, interference, re-examination, post-grant review, inter partes review, nullification or derivation action in court or before patent offices or similar proceedings challenging the validity, enforceability or scope of such patents, which may result in the patent claims being narrowed or invalidated. Furthermore, even if our patents and patent applications are unchallenged, they may not adequately protect our intellectual property, provide exclusivity for our product candidates or prevent others from designing around our claims. Any of these outcomes could impair our ability to prevent competition from third parties.

If the patent applications we hold or have in-licensed with respect to our programs or product candidates fail to issue, or are revoked, if the breadth or strength of our patent protection is threatened, or if our patent portfolio fails to provide meaningful exclusivity for our product candidates, it could dissuade companies from collaborating with us to develop product candidates and threaten our ability to commercialize future products. Any successful opposition to any patents owned by or licensed to us could deprive us of rights necessary for the successful commercialization of any product candidates that we may develop. Further, if we encounter delays in regulatory approvals, the period of time during which we could market a product candidate under patent protection could be reduced. Even where we have a valid and enforceable patent, we may not be able to exclude others from practicing our invention where the other party can show that they used the invention in commerce before our filing date or the other party benefits from a compulsory license. In addition, patents have a limited lifespan. In the United States, the natural expiration of a patent is generally 20 years after it is filed. Various extensions may be available, but the life of a patent, and the protection it affords, is limited. Even if patents covering our product candidates are obtained, once the patent life has expired for a product, we may be open to competition from competitive medications, including biosimilar or generic medications. This risk is material in light of the length of the development process of our products and lifespan of our current patent portfolio.

In addition to the protection afforded by patents, we rely on trade secret protection and confidentiality agreements to protect proprietary know-how that is not patentable or that we elect not to patent, processes for which patents are difficult to enforce and any other elements of our product candidate discovery and development processes that involve proprietary know-how, information or technology that is not covered by patents. However, trade secrets can be difficult to protect. What constitutes a trade secret and what protections are available for trade secrets varies from state to state in the United States and country by country worldwide. We seek to protect our proprietary technology and processes, in part, by entering into confidentiality agreements with our employees, consultants, scientific advisors and contractors. We also seek to preserve the integrity and confidentiality of our data and trade secrets by maintaining physical security of our premises and physical and electronic security of our information technology systems. Security measures may be breached, and we may not have adequate remedies for any breach. In addition, our trade secrets may otherwise become known or be independently discovered by competitors. Although we expect all of our employees and consultants to assign their inventions to us, and all of our employees, consultants, advisors and any third parties who have access to our proprietary know-how, information or technology to enter into confidentiality agreements, we cannot provide any assurances that all such agreements have been duly executed or that our trade secrets and other confidential proprietary information will not be disclosed or that competitors will not otherwise gain access to our trade secrets or independently develop substantially equivalent information and techniques.

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Obtaining and maintaining our patent protection depends on compliance with various procedural, document submission, fee payment and other requirements imposed by governmental patent agencies, and our patent protection could be reduced or eliminated for non-compliance with these requirements.

Periodic maintenance fees, renewal fees, annuity fees and various other governmental fees on patents and applications are required to be paid to the USPTO and various governmental patent agencies outside of the United States in several stages over the lifetime of the patents and applications. The USPTO and various corresponding governmental patent agencies outside of the United States require compliance with a number of procedural, documentary, fee payment and other similar provisions during the patent application process and after a patent has issued. There are situations in which non-compliance can result in abandonment or lapse of the patent or patent application, resulting in partial or complete loss of patent rights in the relevant jurisdiction.

Our success depends, in part, on our ability to protect our intellectual property and our technologies.

Our commercial success depends, in part, on our ability to obtain and maintain patent and trade secret protection for our technologies, our traits, and their uses, as well as our ability to operate without infringing upon the proprietary rights of others. If we do not adequately protect our intellectual property, competitors may be able to use our technologies and erode or negate any competitive advantage we may have, which could harm our business and ability to achieve profitability.

Filing, prosecuting and defending patents on product candidates in all countries around the world would be prohibitively expensive. In addition, we may at times in-license third-party technologies for which limited international patent protection exists and for which the time period for filing international patent applications has passed. Consequently, we may not be able to prevent third parties from practicing our inventions, or from selling or importing products made using our inventions. Potential competitors may use our technologies in jurisdictions where we have not obtained patent protection to develop their own products and further, may export otherwise infringing products to territories where we have patent protection but enforcement is difficult. These products may compete with our product candidates, if approved, and our patents or other intellectual property rights may not be effective or sufficient to prevent them from competing.

Many companies have encountered significant problems in protecting and defending intellectual property rights around the world. The legal systems of certain countries, particularly certain developing countries, do not favor the enforcement of patents, trade secrets and other intellectual property protection, particularly those relating to biotechnology products, which could make it difficult for us to stop the infringement of our patents or marketing of competing products in violation of our proprietary rights generally. Proceedings to enforce our patent rights could result in substantial costs and divert our efforts and attention from other aspects of our business, could put our patents at risk of being invalidated or interpreted narrowly and our patent applications at risk of not issuing and could provoke third parties to assert claims against us. We may not prevail in any lawsuits that we initiate and the damages or other remedies awarded, if any, may not be commercially meaningful. Accordingly, our efforts to enforce our intellectual property rights around the world may be inadequate to obtain a significant commercial advantage from the intellectual property that we develop or license.

Risks Related to Our Reliance on Third Parties

The Company relies on third parties to conduct its pre-clinical studies. If those parties do not successfully carry out their contractual duties or meet expected deadlines, the Company’s drug candidates may not advance in a timely manner or at all.

In the course of discovery, pre-clinical testing and clinical trials, the Company relies on third parties, including laboratories, investigators, clinical contract research organizations (“CROs”), and manufacturers, to perform critical services. For example, the Company relies on third parties to conduct all of its pre-clinical and clinical studies. These third parties may not be available when the Company needs them or, if they are available, may not comply with all regulatory and contractual requirements or may not otherwise perform their services in a timely or acceptable manner, and the Company may need to enter into new arrangements with alternative third parties and the studies may be extended, delayed or terminated. These independent third parties may also have relationships with other commercial entities, some of which may compete with the Company. As a result of the Company’s dependence on third parties, it may face delays or failures outside of its direct control. These risks also apply to the development activities of collaborators, and the Company does not control their research and development, clinical trial or regulatory activities.

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The Company has no direct control over the cost of manufacturing its drug candidates. Increases in the cost of manufacturing the Company’s drug candidates would increase the costs of conducting clinical trials and could adversely affect future profitability.

The Company does not intend to manufacture the drug product candidates in-house, and it will rely on third parties for drug supplies both for clinical trials and for commercial quantities in the future. The Company has taken the strategic decision not to manufacture active pharmaceutical ingredients (“API”) for the drug candidates, as these can be more economically supplied by third parties with particular expertise in this area. The Company outsources the manufacture of its drug products and their testing to FDA requirements. The Company uses contract facilities that are registered with the FDA, have a track record of large-scale API manufacture, and have already invested in capital and equipment. The Company has no direct control over the cost of manufacturing its product candidates. If the cost of manufacturing increases, or if the cost of the materials used increases, these costs may be passed on, making the cost of conducting clinical trials more expensive. Increases in manufacturing costs could adversely affect the Company’s future profitability if it was unable to pass all of the increased costs along to its customers.

Risks Related to our Securities

Enforceability of civil liabilities under the federal securities laws against the Company or the Company’s officers and directors may be difficult.

The Company is a public company limited by shares and is registered and operates under the Australian Corporations Act 2001. Some of the Company’s directors and officers reside outside of the United States. In addition, a substantial portion of the directly owned assets of the Company are located outside of the United States. As a result, it may be difficult or impossible for investors to effect service of process within the United States against the Company or its directors and officers or to enforce against them any of the judgments, including those obtained in original actions or in actions to enforce judgments of the U.S. courts, predicated upon the civil liability provisions of the federal or state securities laws of the United States. There is doubt as to the enforceability in the Commonwealth of Australia, in original actions or in actions for enforcement of judgments of U.S. courts, of civil liabilities predicated solely upon federal or state securities laws of the U.S., especially in the case of enforcement of judgments of U.S. courts where the defendant has not been properly served in Australia.

The trading price of the Company’s ordinary shares and American Depositary Shares (“ADSs”) is highly volatile. Your investment could decline in value and the Company may incur significant costs from class action litigations.

The trading price of the Company’s ordinary shares and ADSs is highly volatile in response to various factors, many of which are beyond the Company’s control, including:

| • |  | unacceptable toxicity findings in animals and humans;

| • |  | lack of efficacy in human trials at Phase II stage or beyond;

| • |  | announcements of technological innovations by the Company and its competitors;

| • |  | new products introduced or announced by the Company or its competitors;

| • |  | changes in financial estimates by securities analysts;

| • |  | actual or anticipated variations in operating results;

| • |  | expiration or termination of licenses, research contracts or other collaboration agreements;

| • |  | conditions or trends in the regulatory climate in the biotechnology, pharmaceutical and genomics industries;

| • |  | changes in the market values of similar companies;

| • |  | the liquidity of any market for the Company’s securities; and

| • |  | additional sales by the Company of its shares.

In addition, equity markets in general and the market for biotechnology and life sciences companies in particular, have experienced substantial price and volume fluctuations that have often been unrelated or disproportionate to the operating performance of the companies traded in those markets. Further changes in economic conditions in Australia, the U.S., EU, or globally, could impact the Company’s ability to grow profitably. Adverse economic changes are outside the Company’s control and may result in material adverse effects on the Company’s business or results of operations. These broad market and industry factors may materially affect the market price of the Company’s ordinary shares and ADSs regardless of its development and operating performance. In the past, following periods of volatility in the market price of a company’s securities, securities class action litigation has often been instituted against that company. Such litigation, if instituted against the Company, could cause it to incur substantial costs and divert management’s attention and resources.

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If the market price of the Company’s ADSs falls and remains below US$5.00 per share, under stock exchange rules, the Company’s stockholders will not be able to use such ADSs as collateral for borrowing in margin accounts. This inability to use ADSs as collateral may depress demand as certain institutional investors are restricted from investing in securities priced below US$5.00 and may lead to sales of such ADSs, creating downward pressure on and increased volatility in the market price of the Company’s ordinary shares and ADSs.

A decrease in the trading price of our ADSs could cause their delisting from NASDAQ.

Under NASDAQ rules, companies listed on the NASDAQ Capital Market are required to maintain a share price of at least US$1.00 per share to avoid delisting of their shares. If the share price declines below US$1.00 for a period of 30 consecutive business days, then that listed company would have 180 days to regain compliance with the US$1.00 per share minimum. In the event that the Company’s share price declines below US$1.00, it may be required to take action, such as a reverse stock split, in order to comply with the NASDAQ rules that may be in effect at the time.

You are reliant on the depositary to exercise your voting rights and to receive distributions on ADSs and, as a result, you may be unable to exercise your voting rights on a timely basis or you may not receive certain distributions.

In certain circumstances, holders of ADSs may have limited rights relative to holders of ordinary shares. The rights of holders of ADSs with respect to the voting of ordinary shares and the right to receive certain distributions may be limited in certain respects by the deposit agreement entered into by us and The Bank of New York Mellon. For example, although ADS holders are entitled under the deposit agreement, subject to any applicable provisions of Australian law and of our Constitution, to instruct the depositary as to the exercise of the voting rights pertaining to the ordinary shares represented by the ADSs, and the depositary has agreed that it will try, as far as practical, to vote the ordinary shares so represented in accordance with such instructions, ADS holders may not receive notices sent by the depositary in time to ensure that the depositary will vote the ordinary shares. This means that, from a practical point of view, the holders of ADSs may not be able to exercise their right to vote. In addition, under the deposit agreement, the depositary has the right to restrict distributions to holders of the ADSs in the event that it is unlawful or impractical to make such distributions. We have no obligation to take any action to permit distributions to holders of our ADSs. As a result, holders of ADSs may not receive distributions.

There is a risk that we are, or will become, a passive foreign investment company, or PFIC, which will subject our U.S. investors to adverse tax rules

There is a risk that we are, or will become, a passive foreign investment company, commonly referred to as a PFIC. Our treatment as a PFIC could result in a reduction in the after-tax return to the U.S. holders of our ordinary shares or ADSs and would likely cause a reduction in the value of such ordinary shares or ADSs. For U.S. federal income tax purposes, we will be classified as a PFIC for any taxable year in which either (i) 75% or more of our gross income is passive income, or (ii) at least 50% of the average quarterly value of all of our assets for the taxable year produce or are held for the production of passive income. If we are classified as a PFIC for U.S. federal income tax purposes, highly complex rules will apply to U.S. holders owning ordinary shares or ADSs. Accordingly, you are urged to consult your tax advisors regarding the application of such rules. See Item 10 - Additional Information - Taxation, United States Federal Income Tax Consequences” for a more complete discussion of the U.S. federal income tax risks related to owning and disposing of our ordinary shares or ADSs.

Currency fluctuations may adversely affect the price of our ordinary shares, ADSs.

Our ordinary shares are quoted in Australian dollars on the ASX and the ADSs are quoted in U.S. dollars on NASDAQ. Movements in the Australian dollar/U.S. dollar exchange rate may adversely affect the U.S. dollar price of the ADSs. In the past year the Australian dollar has generally weakened against the U.S. dollar. However, this trend may not continue and may be reversed.

Australian takeover laws may discourage takeover offers being made for us or may discourage the acquisition of a significant position in our ordinary shares and ADSs.

We are incorporated in Australia and are subject to the takeover laws of Australia. Among other things, we are subject to the Australian Corporations Act 2001, or the Corporations Act. Subject to a range of exceptions, the Corporations Act prohibits the acquisition of a direct or indirect interest in our issued voting shares if the acquisition of that interest will lead to a person’s voting power in us increasing to more than 20%, or increasing from a starting point that is above 20% and below 90%. Australian takeover laws may discourage takeover offers being made for us or may discourage the acquisition of a significant position in our ordinary shares. This may have the ancillary effect of entrenching our board of directors and may deprive or limit our shareholders’ and ADS holders’ opportunity to sell their ordinary shares and ADSs and may further restrict the ability of our shareholders and ADS holders to obtain a premium from such transactions. See Item 10.B “Additional Information – Memorandum and Articles of Association.”

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Item 4. | Information on the Company

A. History and development of the Company

Kazia Therapeutics Limited (“Kazia”), a public company limited by shares, was incorporated in March 1994 under the laws of New South Wales, Australia. Kazia is registered and operates under the Australian Corporations Act 2001.

Kazia has its registered office at Three International Towers, Level 24, 300 Barangaroo Avenue, Sydney, NSW 2000, Australia. Its telephone number and other contact details are: Phone +61-2-9472 4101; email info@kaziatherapeutics.com; and website, www.kaziatherapeutics.com (the information contained in the website does not form part of the Annual Report). Our agent for service of process in the United States is C T Corporation System, 111 Eighth Avenue, New York, New York 10011, USA.

The Company’s Ordinary Shares are listed on the Australian Securities Exchange (“ASX”) under the symbol ‘KZA’ and its ADSs, each representing ten Ordinary Shares, trade on the NASDAQ Capital Market under the symbol ‘KZIA’. The Depositary for the Company’s ADSs is The Bank of New York Mellon, 101 Barclay Street 22W New York, N.Y. 10286. All information we file with the SEC is available through the SEC’s Electronic Data Gathering, Analysis and Retrieval system, which may be accessed through the SEC’s website at www.sec.gov.

B. Business overview

Since its inception in 1994, the principal business of the Company has been pharmaceutical drug development. The Company is an emerging oncology-focused biotechnology company that has a portfolio of development candidates, diversified across several distinct technologies, with the potential to yield first-in-class and best-in-class agents in a range of oncology indications. The lead drug candidate is paxalisib (formerly GDC-0084), a small molecule inhibitor of the PI3K / AKT / mTOR pathway, which is involved in five active trials as follows:

| • |  | A Kazia-sponsored Phase II clinical trial to examine paxalisib in glioblastoma, the most common malignant and highly aggressive form of primary brain tumor in adults;

| • |  | A Phase I clinical trial examining paxalisib in diffuse intrinsic pontine glioma (DIPG), a rare but very aggressive form of childhood brain cancer. This trial is being run by St Jude Children’s Research Hospital;

| • |  | A Phase II study being conducted at Dana-Farber Cancer Institute, examining breast cancer metastases – breast cancer which has spread to the brain – in combination with Herceptin;

| • |  | paxalisib is participating in an NCI funded multi-drug study of brain metastases – cancer which has spread to the brain from any primary tumor. This study is a Phase II trial and is being conducted by the Alliance for Clinical Trials in Oncology; and

| • |  | Memorial Sloan Kettering Cancer Center is investigating the potential use of paxalisib in combination with radiotherapy in a Phase I clinical trial for cancer which has spread to the brain.

Cantrixil (TRX-E-002-1) is the Company’s second clinical asset and is being developed as a potential therapy for ovarian cancer.

The Company has out-licensed all of its other pre-clinical assets to a range of entities in order to focus its time and cash resources on the above two important programs. We hold an ownership stake in those entities in order to share in any upside from successful development of those pre-clinical assets.

Research and Development

Paxalisib (formerly GDC-0084)

The Company’s lead development candidate is paxalisib (formerly known as GDC-0084), a small molecule, brain-penetrant inhibitor of the PI3K / Akt / mTor pathway, that is being developed as a potential therapy for glioblastoma (GBM), the most common most aggressive form of primary brain tumour in adults, as well as other forms of brain cancer. Paxalisib is orally administered and is presented in a 15mg capsule formulation. The development candidate was granted orphan designation for treatment of glioblastoma by the FDA in February 2018, and for treatment of malignant glioma in August 2020. In addition, in August 2020, the FDA awarded Rare Pediatric Disease Designation (RPDD) to paxalisib for the treatment of diffuse intrinsic pontine glioma (DIPG), a rare and highly-aggressive childhood brain cancer, and also Fast Track Designation (FTD) to paxalisib for the treatment of glioblastoma, the most common and the most aggressive form of primary brain cancer in adults.

Paxalisib was developed by Genentech, Inc (headquartered in California) and the Company entered into a worldwide exclusive license for the asset in October 2016. Prior to this transaction, Genentech had completed an extensive preclinical development program that provided convincing validation for paxalisib as a potential drug for brain cancer. Genentech also completed a phase I clinical trial in 47 patients with advanced recurrent grade III and grade IV glioma. The most common adverse events were oral mucositis and hyperglycemia. Per RANO criteria, 40% of patients exhibited a best observable response of stable disease, and 26% demonstrated a metabolic partial response on FDG-PET.

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The development candidate was granted the International Non-Proprietary Name (INN) ‘paxalisib’ by the World Health Organisation in December 2019. This was confirmed as the United States Adopted Name (USAN) by the USAN Council in April 2020.

During the period, the Company has completed recruitment to a phase IIa clinical study in patients with newly-diagnosed glioblastoma who exhibit unmethylated MGMT promotor status (NCT03522298). Unmethylated MGMT status confers near-total resistance to temozolomide, the existing standard of care, and represents approximately two-thirds of the total incident GBM population. This phase IIa study recruited patients at five centres in the United States.

In May 2019, the Company reported interim data from the initial dose escalation component of the study. In the newly-diagnosed population, a maximum tolerated dose (MTD) of 60mg was achieved, which is higher than the MTD of 45mg reported in the phase I study in recurrent patients. Adverse events were generally mild and reversible. Dose-limiting toxicities of mucositis and hyperglycemia were consistent with the PI3K inhibitor class and with prior clinical experience of this agent. In November 2019, the company reported initial interim efficacy data from the dose escalation component at the Society for Neuro-Oncology (SNO) Annual Meeting. These data showed a median progression-free survival of 8.4 months, which compares favourably in an indirect comparison to temozolomide, the existing standard of care, which is associated with a mPFS of 5.3 months in this population. In June 2020, an additional interim analysis was presented at the American Association of Cancer Research (AACR) Virtual Annual Meeting II, which showed a mPFS of 8.5 months on the entire data set and a median overall survival (OS) of 17.7 months. The corresponding figure for temozolomide is 12.7 months. Final data is expected in late CY2020 or early CY2021.

In February 2020, the Company’s collaborators at St Jude Children’s Research Hospital in Memphis completed recruitment to a phase I investigator-initiated clinical study of paxalisib in diffuse intrinsic pontine glioma (DIPG), a rare but highly-aggressive childhood brain cancer with no approved pharmacological treatments (NCT03696355). The St Jude study seeks to establish an MTD in the paediatric population before enrolling an expansion cohort to seek definitive signals of efficacy. The St Jude study is primarily funded by the hospital, with support via a financial grant from Kazia. In September 2019, the company announced that a pediatric MTD of 27 mg/m2 had been determined, which is approximately comparable to the doses used in adult clinical studies. Initial interim efficacy data is expected in 2H CY2020.

A phase II investigator-initiated clinical study is ongoing at Dana-Farber Cancer Institute in Boston, MA, exploring paxalisib in combination with Herceptin (trastuzumab) for HER2+ breast cancer brain metastases, a population for which there are again no approved pharmacological treatments (NCT03765983). The Dana-Farber study is primarily funded by the hospital, with support via a financial grant from Kazia. Initial interim efficacy data is expected in 2H CY2020.

In May 2019, the Company joined a phase II clinical study sponsored by the Alliance for Clinical Trials in Oncology, a large academic research organisation, and funded by the US National Cancer Institute (NCT03994796). The Alliance study is a genomically-guided, multi-drug study in patients with brain metastases from any primary tumour. Those with mutations affecting the PI3K / Akt / mTOR pathway will be assigned to receive paxalisib, while patients with other driving mutations may receive abemaciclib (Eli Lilly & Company) or entrectenib (Genentech, Inc). The study commenced recruitment on schedule in July 2019, and is expected to recruit approximately 150 patients, evenly divided between the three treatment arms, over the course of a two-year period. The company is not yet in a position to provide guidance on the timing of likely data read-outs.

In July 2019, the Company entered into a collaboration with researchers at Memorial Sloan Kettering Cancer Center in New York, NY to conduct a phase I clinical study with paxalisib in combination with radiotherapy for brain metastases and leptomeningeal metastases (NCT04192981). The Sloan Kettering study is primarily funded by the hospital, with support via a financial grant from Kazia. Recruitment commenced in Q4 CY2019 and the study is ongoing.

In September 2020 the Company announced a further collaboration with Dana-Farber Cancer Institute to investigate the use of paxalisib in primary central nervous system (CNS) lymphoma, a potential new indication for the drug.

In December 2019, the company entered into a preliminary agreement with the Global Coalition for Adaptive Research (GCAR), a US-based 501(C)(3) non-profit organisation dedicated to advancing the development of new therapies via the application of cutting edge statistical methodologies. The agreement relates to set-up work for the planned entry of paxalisib into GBM AGILE, an international multi-drug platform study in glioblastoma that is sponsored by GCAR. The first agent to enter GBM AGILE was Bayer’s Stivarga (regorafenib), and paxalisib was invited onto the study as the second agent by GCAR’s Arm Selection Committee in 4Q CY2019. It is envisaged that further agents will be added in due course. GBM AGILE is heavily supported by clinicians and regulatory agencies, and provides an optimal path to market for paxalisib in glioblastoma. As a result, the Company has discontinued development of its own planned phase III clinical study and has adopted GBM AGILE as the pivotal study for registration of paxalisib. It is expected that recruitment to the paxalisib arm will commence in the last quarter of calendar 2020.

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Two key research papers were published in relation to paxalisib during FY2020. First, a paper by Wen et al. in Clinical Cancer Research presented a definitive analysis of the Genentech phase I clinical study in recurrent glioma. This data had previously only been available to researchers via a 2016 ASCO poster. Second, Ellingson et al. published a paper in the same journal detailing a post hoc analysis of the Genentech phase I study, using advanced imaging analysis methodologies. The Ellingson analysis was able to correlate plasma concentrations of paxalisib with pharmacodynamic changes on MRI and PET, and to also connect those changes with progression-free survival. As such, the analysis provides a powerful pharmacodynamic proof-of-concept for the drug in glioblastoma.

Cantrixil (TRX-E-002-1)

Cantrixil (TRX-E-002-1) is the Company’s second clinical asset and is derived from a proprietary drug discovery program. It is being developed as a potential therapy for ovarian cancer.

Research undertaken by Yale University (New Haven, Connecticut) has provided preclinical evidence that Cantrixil is active against both differentiated cancer cells and tumor-initiating cells (sometimes referred to as ‘cancer stem cells’). The latter are thought to be an important component of chemotherapy resistance and disease recurrence in diseases such as ovarian cancer, and thus Cantrixil has potential to offer benefit to the approximately three-quarters of ovarian cancer patients who are not adequately managed by conventional chemotherapy treatments.

In December 2016, the Company commenced a phase I clinical trial of Cantrixil in patients with ovarian cancer (NCT02903771). The study is designed to establish the safety and tolerability of the development candidate, to determine a Maximum Tolerated Dose (MTD), and to explore indicative signals of clinical efficacy. Data from the initial dose escalation cohort was reported at the American Association of Cancer Research meeting in April 2019. Cantrixil was broadly well-tolerated, and an MTD of 5 mg/kg was determined. Dose-limiting toxicities were generally gastrointestinal in nature. The company presented an interim efficacy analysis at the American Association of Cancer Research (AACR) Virtual Annual Meeting II, which reported a median progression-free survival of 5.5 months. Of 16 evaluable patients, one exhibited a complete response (CR), and two demonstrated a partial response to treatment (PR), making for an overall response rate (ORR) of 19%. The Company expects to report final data from this study by the end of calendar 2020.

Patent Protection

The Company has an aggressive global Intellectual Property (“IP”) strategy to protect its key assets and we have partnered with a global patent law firm to lodge patents that offer the best possible protection for our assets. The patent strategy is adapted for each technology platform and the principle mode of protection is through the patenting procedure, seeking to obtain exclusive licenses for all its key inventions and drug pipeline. The overarching strategy in the IP portfolio is to cover the three critical corner stones of pharmaceutical patent: composition of matter (the breadth structures covered in the patent), method of manufacture (the chemical processes used to manufacture the compounds disclosed in the patent) and method of use. Patents are submitted initially as provisional applications and after 12 months’ progress through to a Patent Cooperation Treaty (“PCT”) application.

Drug discovery/development efforts are contributing to our pipeline with our other technology platforms also delivering hit and lead drug candidates. As the research programs reveal new hit molecules, these are protected through lodging patents. The Company will continue to pursue a broad patent filing strategy based on multiple jurisdictions with a focus on those member countries offering the most significant market opportunities for future development.

Regulatory requirements

Australian Regulatory Requirements

The Therapeutic Goods Act 1989 (“1989 Act”), sets out the legal requirements for the import, export, manufacture and supply of pharmaceutical products in Australia. The 1989 Act requires that all pharmaceutical products to be imported into, supplied in, manufactured in or exported from Australia be included in the Australian Register of Therapeutic Goods (“ARTG”), unless specifically exempted under the Act.

Medicines with a higher level of risk (prescription medicines, some non-prescription medicines) are evaluated for quality, safety and efficacy and are registered on the ARTG. Medicines with a lower risk (many over the counter medicines including vitamins) are assessed only for quality and safety. Medicines included in the ARTG can be identified by the AUST R number (for registered medicines) or an AUST L number (for listed medicines) which appears on the packaging of the medicine.

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In order to ensure that a product can be included in the ARTG, a sponsoring company must make an application to the Therapeutic Goods Administration (“TGA”). The application usually consists of a form accompanied by data (based on the EU requirements) to support the quality, safety and efficacy of the product for its intended use and payment of a fee. Application details are available on the TGA website www.tga.gov.au.

The first phase of evaluation, known as the Application Entry Process, is usually a short period during which an application is assessed at an administrative level to ensure that it complies with the basic guidelines. The TGA may request further details from the applicant and may agree with sponsors that additional data (which while not actually required by the application, could enhance the assessment outcome) may be submitted later at an agreed time. The TGA must decide within at least 40 working days whether it will accept the application for evaluation.

Once an application is accepted for evaluation, aspects of the data provided are allocated to evaluators within the different relevant sections, who prepare clinical evaluation reports. Following evaluation, the chemistry, quality control bioavailability and pharmacokinetics aspects of a product may be referred to a Pharmaceutical Sub-Committee (“PSC”), which is a sub-committee of the TGA prescription medicine expert advisory committee, the Advisory Committee on Prescriptive Medicines (“ACPM”) to review the relevant clinical evaluation reports.

The clinical evaluation reports (along with any resolutions of the ACPM sub-committee) are sent to the sponsoring company who then has the opportunity to comment on the views expressed within the evaluation report, provide corrections and to submit supplementary data to address any issues raised in the evaluation reports.

Once the evaluations are complete, the TGA prepares a summary document on the key issues on which advice will be sought from either the ACPM (for new medicines) or from the Peer Review Committee (“PRC”) for extensions to products which are already registered. This summary is sent to the sponsoring company, which is able to submit a response to the ACPM or PRC dealing with issues raised in the summary and those not previously addressed in the evaluation report. The ACPM/PRC provide independent advice on the quality, risk/benefit, effectiveness and access of the product and conduct medical and scientific evaluations of the application. The ACPM meets every two months to examine the applications referred by the TGA and its resolutions are provided to the sponsoring company within five working days after the ACPM meeting.

The TGA takes into account the advice of the ACPM or PRC in reaching a decision to approve or reject a product. Any approval for registration on the ARTG may have conditions associated with it.

From the time that the TGA accepts the initial application for evaluation, the TGA must complete the evaluation and make a decision on the registration of the product within at least 255 working days. If not completed within 255 working days, the TGA forfeits 25% of the evaluation fee otherwise payable by the sponsor, but any time spent waiting for a response from the sponsor is not included in the 255 working days. The TGA also has a system of priority evaluation for products that meet certain criteria, including where the product is a new chemical entity that it is not otherwise available on the market as an approved product, and is for the treatment of a serious, life-threatening illness for which other therapies are either ineffective or not available.

U.S. Regulatory Requirements

The FDA regulates and imposes substantial requirements upon the research, development, pre-clinical and clinical testing, labelling, manufacture, quality control, storage, approval, advertising, promotion, marketing, distribution, import and export of pharmaceutical products including drugs and biologics, as well as significant reporting and record-keeping obligations. State governments may also impose obligations in these areas.

In the United States, pharmaceutical products are regulated by the FDA under the Federal Food, Drug, and Cosmetic Act (“FDCA”), and other laws in the case of biologics, the Public Health Service Act and other acts that implement regulations. The Company believes that the FDA will regulate its products as drugs. The process required by the FDA before drugs may be marketed in the United States generally involves the following:

| • |  | pre-clinical laboratory evaluations, including formulation and stability testing, and animal tests performed under the FDA’s Good Laboratory Practices regulations to assess pharmacological activity and toxicity potential;

| • |  | submission and approval of an IND Application, including results of pre-clinical studies, clinical experience, manufacturing information, and protocols for clinical tests, which must become effective before clinical trials may begin in the United States;

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| • |  | obtaining approval of Institutional Review Boards (“IRBs”), to administer the products to human subjects in clinical trials;

| • |  | adequate and well-controlled human clinical trials to establish the safety and efficacy of the product for the product’s intended use;

| • |  | development of manufacturing processes which conform to FDA current Good Manufacturing Practices (“cGMPs”), as confirmed by FDA inspection;

| • |  | submission of results for pre-clinical and clinical studies, and chemistry, manufacture and control information on the product to the FDA in a New Drug Approval (“NDA”) Application; and

| • |  | FDA review and approval of an NDA, prior to any commercial sale, promotion or shipment of a product.

The testing and approval process requires substantial time, effort, and financial resources, and the Company cannot be certain that any approval will be granted on a timely basis, if at all.

The results of the pre-clinical studies, clinical experience together with initial specified manufacturing information, the proposed clinical trial protocol, and information about the participating investigators are submitted to the FDA as part of an IND, which must become effective before the Company may begin human clinical trials in the U.S. Additionally, an independent IRB must review and approve each study protocol and oversee conduct of the trial. An IND becomes effective 30 days after receipt by the FDA, unless the FDA, within the 30-day period, raises concerns or questions about the conduct of the trials as outlined in the IND and imposes a clinical hold. If the FDA imposes a clinical hold, the IND sponsor must resolve the FDA’s concerns before clinical trials can begin. Pre-clinical tests and studies can take several years to complete, and there is no guarantee that an IND submitted, based on such tests and studies, will become effective within any specific time period, if at all.

Human clinical trials are typically conducted in three sequential phases that may overlap, which are:

| • |  | Phase I: The drug is initially introduced into healthy human subjects or patients and tested for safety and dosage tolerance. For oncology medicines, patients with the target disease are used rather than healthy patients. Absorption, metabolism, distribution, and excretion testing, among other tests, are generally performed at this stage. These studies may also provide early evidence of effectiveness. The maximum tolerated dose of the drug may be calculated from Phase I studies;

| • |  | Phase II: The drug is studied in controlled, exploratory therapeutic trials in a limited number of subjects with the disease or medical condition for which the new drug is intended to be used in order to identify possible adverse effects and safety risks, to determine the preliminary or potential efficacy of the product for specific targeted diseases or medical conditions, and to determine dosage tolerance and the optimal effective dose; and

| • |  | Phase III: While Phase II studies demonstrate that a specific dosage range of the drug is likely to be effective and the drug has an acceptable safety profile, controlled, large-scale therapeutic, Phase III trials are undertaken at multiple study sites to demonstrate clinical efficacy and to further test for safety in an expanded patient population. These studies are used to evaluate the overall benefit – risk relationship of the drug and provide a basis for physician labelling.

The Company cannot be certain that it will successfully complete Phase I, Phase II or Phase III testing of its products within any specific time period, if at all. Furthermore, the FDA, the IRB or the Company may suspend or terminate clinical trials at any time on various grounds, including a finding that the subjects or patients are being exposed to an unacceptable health risk.

Results of pre-clinical studies and clinical trials, as well as detailed information about the manufacturing process, quality control methods, and product composition, among other things, are submitted to the FDA as part of an NDA seeking approval to market and commercially distribute the product on the basis of a determination that the product is safe and effective for its intended use. Before approving an NDA, the FDA will inspect the facilities at which the product is manufactured and will not approve the product unless GMP compliance is satisfactory. If applicable regulatory criteria are not satisfied, the FDA may deny the NDA or require additional testing or information. As a condition of approval, the FDA also may require post-marketing testing or surveillance to monitor the product’s safety or efficacy. Even after an NDA is approved, the FDA may impose additional obligations or restrictions (such as labelling changes), or even suspend or withdraw a product approval on the basis of data that arise after the product reaches the market, or if compliance with regulatory standards is not maintained. The Company cannot be certain that the FDA on a timely basis, if at all will approve any NDA it submits. Also, any such approval may limit the indicated uses for which the product may be marketed. Any refusal to approve, delay in approval, suspension or withdrawal of approval, or restrictions on indicated uses could have a material adverse impact on the Company’s business prospects.

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A user fee, pursuant to the requirements of the Prescription Drug User Fee Act (“PDUFA”), and its amendments, applies to NDAs. The FDA adjusts the PDUFA user fees on an annual basis. PDUFA also imposes an annual product fee for prescription drugs and biologics, and an annual establishment fee on facilities used to manufacture prescription drugs and biologics. A written request can be submitted for a waiver under certain circumstances. Waivers may be possible for the application fee for the first human drug application that is filed by a small business, as defined by the FDCA, but there are no small business waivers for product or establishment fees. Waivers may also be possible for one or more fees, upon written request, when a waiver or reduction is necessary to protect the public health, the user fees would present a significant barrier to innovation, or the fees are anticipated to exceed the present or future costs incurred by FDA. The Company is not at the stage of development with its products where it is subject to these fees, but they are significant expenditures that may be incurred in the future and must be paid at the time of application submissions to FDA.

Satisfaction of FDA requirements typically takes several years. The actual time required varies substantially, based upon the type, complexity, and novelty of the pharmaceutical product, among other things. Government regulation imposes costly and time-consuming requirements and restrictions throughout the product life cycle and may delay product marketing for a considerable period of time, limit product marketing, or prevent marketing altogether. Success in pre-clinical or early stage clinical trials does not ensure success in later stage clinical trials. Data obtained from pre-clinical and clinical activities are not always conclusive and may be susceptible to varying interpretations that could delay, limit, or prevent marketing approval. Even if a product receives marketing approval, the approval is limited to specific clinical indications. Further, even after marketing approval is obtained, the discovery of previously unknown problems with a product may result in restrictions on the product or even complete withdrawal of the product from the market.

After product approval, there are continuing significant regulatory requirements imposed by the FDA, including record-keeping requirements, obligations to report adverse events in patients using the products, and restrictions on advertising and promotional activities. Quality control and manufacturing procedures must continue to conform to GMPs, and the FDA periodically inspects facilities to assess GMP compliance. Additionally, post-approval changes in ingredient composition, manufacturing processes or facilities, product labelling, or other areas may require submission of an NDA Supplement to the FDA for review and approval. New indications will require additional clinical studies and submission of an NDA Supplement. Failure to comply with FDA regulatory requirements may result in an enforcement action by the FDA, including warning letters, product recalls, suspension or revocation of product approval, seizure of product to prevent distribution, impositions of injunctions prohibiting product manufacture or distribution, and civil and criminal penalties. Maintaining compliance is costly and time-consuming. The Company cannot be certain that it, or its present or future suppliers or third-party manufacturers, will be able to comply with all FDA regulatory requirements, and potential consequences of noncompliance could have a material adverse impact on its business prospects.

The FDA’s policies may change, and additional governmental regulations may be enacted that could delay, limit, or prevent regulatory approval of the Company’s products or affect its ability to manufacture, market, or distribute its products after approval. Moreover, increased attention to the containment of healthcare costs in the U.S. and in foreign markets could result in new government regulations that could have a material adverse effect on the business. The Company’s failure to obtain coverage, an adequate level of reimbursement, or acceptable prices for future products could diminish any revenues the Company may be able to generate. The Company’s ability to commercialize future products will depend in part on the extent to which coverage and reimbursement for the products will be available from government and health administration authorities, private health insurers, and other third-party payers. EU member states and U.S. government and other third-party payers increasingly are attempting to contain healthcare costs by consideration of new laws and regulations limiting both coverage and the level of reimbursement for new drugs. The Company cannot predict the likelihood, nature or extent of adverse governmental regulation that might arise from future legislative or administrative action, either in the U.S. or abroad.

The Company’s activities may also be subject to state laws and regulations that affect its ability to develop and sell products. The Company is also subject to numerous federal, state, and local laws relating to such matters as safe working conditions, clinical, laboratory, and manufacturing practices, environmental protection, fire hazard control, and disposal of hazardous or potentially hazardous substances. The Company may incur significant costs to comply with such laws and regulations now or in the future, and the failure to comply may have a material adverse impact on the Company.

The FDCA includes provisions designed to facilitate the development and expedite the review of drugs and biological products intended for treatment of serious or life-threatening conditions that demonstrate the potential to address unmet medical needs for such conditions. These provisions set forth a procedure for designation of a drug as a “fast track product”. The fast track designation applies to the combination of the product and specific indication for which it is being studied. A product designated as fast track is ordinarily eligible for additional programs for expediting development and review, but products that are not in fast-track drug development programs may also be able to take advantage of these programs if they meet the necessary requirements. These programs include priority review of NDAs and accelerated approval. Drug approval under the accelerated approval regulations may be based on evidence of clinical effect on a surrogate endpoint that is reasonably likely to predict clinical benefit. A post-marketing clinical study will be required to verify clinical benefit, and other restrictions to assure safe use may be imposed.

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Under the Drug Price Competition and Patent Term Restoration Act of 1984, a sponsor may obtain marketing exclusivity for a period of time following FDA approval of certain drug applications, regardless of patent status, if the drug is a new chemical entity or if new clinical studies were required to support the marketing application for the drug. This marketing exclusivity prevents a third party from obtaining FDA approval for an identical or nearly identical drug under an Abbreviated New Drug Application or a “505(b)(2) New Drug Application”. The statute also allows a patent owner to obtain an extension of applicable patent terms for a period equal to one-half the period of time elapsed between the filing of an IND and the filing of the corresponding NDA plus the period of time between the filing of the NDA and FDA approval, with reductions taken for any time an applicant did not act with due diligence. There is a five-year maximum patent extension and a maximum of 14 years protection from product approval. The Company cannot be certain that it will be able to take advantage of either the patent term extension or marketing exclusivity provisions of these laws.

European Union Regulatory Requirements

Outside the United States, the Company’s ability to market its products will also be contingent upon receiving marketing authorizations from the appropriate regulatory authorities and compliance with applicable post-approval regulatory requirements. Although the specific requirements and restrictions vary from country to country, as a general matter, foreign regulatory systems include risks similar to those associated with FDA regulation, described above. Under EU regulatory systems, marketing authorizations may be submitted either under a centralized or a national procedure. Under the centralized procedure, a single application to the European Medicines Agency (“EMA”) leads to an approval granted by the European Commission that permits the marketing of the product throughout the EU. The centralized procedure is mandatory for certain classes of medicinal products, but optional for others. For example, all medicinal products developed by certain biotechnological means, and those developed for cancer and other specified diseases and disorders, must be authorized via the centralized procedure. The Company assumes that the centralized procedure will apply to its products that are developed by means of a biotechnology process. The national procedure is used for products not requiring authorization by the centralized procedure. Under the national procedure, an application for a marketing authorization is submitted to the competent authority of one-member state of the EU. The holders of a national marketing authorization may submit further applications to the competent authorities of the remaining member states via either the decentralized or mutual recognition procedure. The decentralized procedure enables applicants to submit an identical application to the competent authorities of all member states where approval is sought at the same time as the first application, while under the mutual recognition procedure, products are authorized initially in one-member state, and other member states where approval is sought are then requested to recognize the original authorization based upon an assessment report prepared by the original authorizing competent authority. Both the decentralized and mutual recognition procedures should take no longer than 90 days, but if one-member state makes an objection, which under the legislation can only be based on a possible risk to human health, the application will be automatically referred to the Committee for Medicinal Products for Human Use (“CHMP”) of the EMA. If a referral for arbitration is made, the procedure is suspended. However, member states that have already approved the application may, at the request of the applicant, authorize the product in question without waiting for the result of the arbitration. Such authorizations will be without prejudice to the outcome of the arbitration. For all other concerned member states, the opinion of the CHMP, which is binding, could support or reject the objection or alternatively could reach a compromise position acceptable to all EU countries concerned. The arbitration procedure may take an additional year before a final decision is reached and may require the delivery of additional data.

As with FDA approval, the Company may not be able to secure regulatory approvals in the EU in a timely manner, if at all. Additionally, as in the U.S., post-approval regulatory requirements, such as those regarding product manufacture, marketing, or distribution, would apply to any product that is approved in the EU, and failure to comply with such obligations could have a material adverse effect on the Company’s ability to successfully commercialize any product.

The conduct of clinical trials in the EU is governed by the European Clinical Trials Directive (2001/20/EC), which was implemented in May 2004. This Directive governs how regulatory bodies in member states control clinical trials. No clinical trial may be started without a clinical trial authorization granted by the national competent authority and favorable ethics approval.

Accordingly, there is a marked degree of change and uncertainty both in the regulation of clinical trials and in respect of marketing authorizations that face the Company or its products in the EU.

The Company has met the compliance requirements for ASX listings and accordingly has not been in breach of those requirements.

Product and Corporate Developments during Fiscal 2020

The Company continued to pursue its strategy of focusing resources on clinical programs, being those most likely to provide a return to shareholders.

In November 2019, the Company raised $3.7 million (net of costs) from a share placement to industry investors, and in April/May 2020, the Company raised an additional $8.4 million (net of costs) from a share placement to industry investors, as well as a Share Purchase Plan to qualifying shareholders. Together these two sources of funds substantially funded the operations of the Company for fiscal 2020.

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In October 2020, the Company raised a further $23 million (net of costs) from a fully underwritten entitlement offer to eligible shareholders. The funds raised will provide funding for the GCAR study.

As well as our two ongoing clinical trials, the Company’s assets are now also involved in a further five clinical trials, all being conducted by world renowned research organization and principally funded by parties other than Kazia, giving us multiple opportunities to realise value from our drugs.

The Company has continued to make all efforts to improve operating efficiency and maintain the current low rate of G&A costs, allowing the bulk of the company’s funds to be directed towards our research and development activities. Cash outlaid in relation to our clinical programs represented 72% of the total cash outlay for the year, as compared to 63% in the prior fiscal period.

C. Organizational structure

Kazia Therapeutics Limited is incorporated in Australia and has the following wholly-owned subsidiaries:

Name |  | Country of incorporation
Kazia Laboratories Pty Ltd |  | Australia
Kazia Research Pty Ltd |  | Australia
Kazia Therapeutics Inc. |  | United States (Delaware)
Glioblast Pty Ltd |  | Australia

D. Property, plant and equipment

During fiscal 2020, the Company continued to work out of a serviced office in Sydney that is subject to a renewable one-year workspace license agreement.

Item 4A. | Unresolved Staff Comments

None.

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Item 5. | Operating and Financial Review and Prospects

Critical accounting policies

We prepare our financial statements in accordance with International Financial Reporting Standards (IFRS) as issued by the International Accounting Standards Board (IASB). As such, we are required to make certain estimates, judgments, and assumptions that management believes are reasonable based upon the information available. These estimates, judgments and assumptions affect the reported amounts of assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the periods presented. The critical accounting policies are summarized in Item 18. “Financial Statements—Note 3 – Critical Accounting Policies”.

The following discussion and analysis should be read in conjunction with Item 18. “Financial Statements” included below. Operating results are not necessarily indicative of results that may occur in future periods. This discussion and analysis contains forward-looking statements that involve risks, uncertainties and assumptions. The actual results may differ materially from those anticipated in the forward-looking statements as a result of many factors including, but not limited to, those set forth under “Forward-Looking Statements” and “Risk Factors” in Item 3 “Key Information” included above in this Annual Report on Form 20-F. All forward-looking statements included in this document are based on the information available to the Company on the date of this document and the Company assumes no obligation to update any forward-looking statements contained in this Annual Report on Form 20-F.

A. Operating results

The following discussion relates to our consolidated results of operations, financial condition and capital resources. You should read this discussion in conjunction with our consolidated financial statements and the notes thereto contained elsewhere in this report.

The following tables provide a summary of revenues and income for the past three fiscal years:

|  | For the fiscal year ended June 30, |
|  | 2020 |  |  | 2019 |  |  | 2018 |
|  | A$’000 |  |  | A$’000 |  |  | A$’000 |
Revenue |  |  | — |  |  |  | — |  |  |  | 119 |
Finance income |  |  | 66 |  |  |  | 100 |  |  |  | — |
Other income: |  |  |  |  |  |  |  |  |  |  |  |
Net foreign exchange gain |  |  | 5 |  |  |  | — |  |  |  | 224 |
Payroll tax rebate |  |  | 2 |  |  |  | — |  |  |  | — |
Reimbursement of expenses |  |  | — |  |  |  | 25 |  |  |  | 8 |
Gain on legal settlement |  |  | — |  |  |  | — |  |  |  | 8,411 |
Research and development rebate |  |  | 968 |  |  |  | 1,431 |  |  |  | 2,200 |
Subsidies and grants |  |  | 20 |  |  |  | 9 |  |  |  | 685 |
Gain on Revaluation of Contingent Consideration |  |  | — |  |  |  | — |  |  |  | 1,461 |
Total revenue and other income |  |  | 1,061 |  |  |  | 1,565 |  |  |  | 13,108 |

Fiscal 2020 compared to fiscal 2019

Finance income and other income

The Company earns interest income derived from interest bearing bank account, which is directly linked with the amounts held on deposit. The amount of finance income earned decreased as a result of decreased cash balances as well as lower interest rates enjoyed during the year.

Research and development rebate decreased from A$1.4 million in fiscal 2019 to A$1.0 million in fiscal 2020. The key factor influencing this reduction was the reduced level of R&D expenditure incurred in Australia during fiscal 2020 because the majority of the R&D expenditure on the paxalisib trials is expended in the United States and is therefore not eligible for the rebate. We expect an increasing amount of our R&D expenditure to occur in the United States and, as a result, we expect our R&D rebate from the Australian government to continue to decline.

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Expenses

Research and development expenses increased from A$6.5 million in fiscal 2019 to A$9.5 million in fiscal 2020 (47%) as a result of the development in the Company’s two main clinical programs, particularly the Kazia-sponsored Phase II clinical trial to examine paxalisib in glioblastoma.

General and administrative costs decreased slightly from A$3.8 million in fiscal 2019 to A$3.7 million in fiscal 2020 (-3%) as a result of the Company’s continued focus on cost containment during fiscal 2020.

Net loss

The Company’s loss after income tax increased from A$10.3 million in fiscal 2019 to A$12.5 million in fiscal 2020. The change was mainly as a result increased R&D expenditure during the fiscal 2020 as described above, as well as the lower research and development rebate received from the Australian government in fiscal 2020, also as described above.

Fiscal 2019 compared to fiscal 2018

This analysis can be found in Item 5 of the Company’s annual report on Form 20-F for fiscal 2019.

B. Liquidity and capital resources

We have incurred cumulative losses and negative cash flows from operations since our inception and, as of June 30, 2020, we had accumulated losses of A$36.2 million. We anticipate that we will continue to incur losses for at least the next several years. We expect that our research and development expenditure will continue to increase and, as a result, we will need additional capital to fund our operations, which we may raise through a combination of equity offerings, other third-party funding, and other collaborations, strategic alliances and licensing arrangements.

We had no borrowings in fiscal 2020 and do not currently have a credit facility.

As of June 30, 2020, we had cash and cash equivalents of A$8.8 million. Cash in excess of immediate requirements is invested in accordance with our investment policy, primarily with a view to liquidity and capital preservation. Currently, our cash and cash equivalents are held in bank accounts. Our short-term investments consist of term deposits with maturity within 90 days. At June 30, 2020, term deposits amounting to A$7.5 million had a weighted average interest rate of 0.95%.

We expect to consume cash and incur operating losses for the foreseeable future as the Company continues developing its oncology drug candidates. The impact on cash resources and results from operations will vary with the extent and timing of the future clinical trial programs. The financial statements have been prepared on a going concern basis, which contemplates continuity of normal activities and realization of assets and settlement of liabilities in the normal course of business. As is often the case with drug development companies, the Company’s ability to continue its development activities as a going concern is dependent upon it deriving sufficient cash from investors, from licensing and partnering activities and from other sources of revenue such as grant funding. The directors have considered the cash flow forecasts and the funding requirements of the business and are confident that the strategies in place are appropriate to generate sufficient funding to allow us to continue as a going concern.

Cash flows

The following table set forth the sources and uses of cash for the past three fiscal years:

(in A$ thousands) |  | 2020 |  |  | 2019 |  |  | 2018 |
Net cash used in operating activities |  |  | (8,809 | ) |  |  | (6,714 | ) |  |  | (8,661 | )
Net cash from investing activities |  |  | — |  |  |  | 2,359 |  |  |  | 150 |
Net cash from financing activities |  |  | 12,139 |  |  |  | 3,815 |  |  |  | — |

Operating activities. Net cash used in operating activities for the three fiscal years primarily represents net outflows for the cost of the R&D programs and the general and administrative costs of running the business. This amount is heavily impacted by the cost of the clinical programs, as well as cost containment measures adopted to manage the general and administrative costs of the business.

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Investing activities. Net cash from investing activities in fiscal 2018 represents the cash portion of a legal settlement while the cash inflow in fiscal 2019 represents funds generated from the sale of shares in a listed entity, which were obtained via the settlement of an IP dispute.

Financing activities. Net cash from financing activities in fiscal 2020 and 2019 arose as a result of private placements of ordinary shares to institutional investors in certain countries as well as Share Purchase Plans to shareholders in Australia. No such financing activity occurred in fiscal 2018.

At June 30, 2020, the Company did not hold any derivative financial instruments for managing its foreign currency; however, the Company may from time to time enter into hedging arrangements where circumstances are deemed appropriate.

The Company believes that its future ability to fund its operations will depend on deriving sufficient cash from investors through successful capital raisings, from licensing and partnering activities and government grants.

The Company had no commitments for capital expenditure at the end of fiscal 2020.

The Company continuously pursues opportunities for non-dilutive funding, such as grant applications.

The Company cannot provide assurance that it or its subsidiaries will be able to raise the funds necessary to complete the planned clinical trial programs or find appropriate collaboration or licensing opportunities.

Financing activities

Equity issues

The Company has historically financed its operations primarily from issuing equity capital.

During fiscal 2018 the Company undertook a consolidation of its share capital whereby one new ordinary share represented 10 of the old ordinary shares. As a result of fractional holdings, an additional 830 of “old” ordinary shares were issued during this process. In addition, a further 80,000 “new” ordinary shares were issued during fiscal 2018 to the Company’s Scientific Advisory Board in consideration of services rendered.

During fiscal 2019 the Company issued 13,757,052 ordinary shares. The details of these share issues are as follows:

| • |  | In October 2018 the Company issued 8,900,001 shares to industry funds and other investors and raised A$3,382,000 before costs.

| • |  | In November 2018, the Company issued 2,820,824 shares in relation to a milestone associated with the acquisition of Glioblast Pty Limited

| • |  | In November 2018 the Company issued 2,036,227 shares to qualifying existing shareholders under the Company’s Share Purchase Plan, raising funds of A$773,760 before costs.

During fiscal 2020 the Company issued 32,431,696 ordinary shares. The details of these share issues are as follows:

| • |  | In November 2019, the Company issued 10,000,000 shares to industry funds and other investors and raised A$4,000,000 before costs.

| • |  | In April 2020, the Company issued 18,041,667 shares to industry funds and other investors and raised A$7,216,667 before costs.

| • |  | In May 2020 the Company issued 4,390,010 shares to qualifying existing shareholders under the Company’s Share Purchase Plan, raising funds of A$1,756,004 before costs.

During fiscal 2020, 19 options were exercised raising A$76.

Foreign currency fluctuations were not material for the Company in fiscal 2020. See Item 18. “Financial Statements—Note 22 – Financial Instruments” for disclosures about financial risk management including interest rate risk, foreign currency risk and liquidity risk.

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Convertible note (Triaxial) carrying value of A$464,000

During the year ended June 30, 2013 the Company issued Convertible Notes with a face value of A$1,500,000 to Triaxial in consideration of the acquisition of patents and intellectual property assets. The terms of these Convertible Notes were amended on December 4, 2014. The amended terms allow the conversion of debt into ordinary shares, provided that the Company achieves certain milestones. Accordingly, the Convertible Note has been reclassified as an equity instrument rather than debt instrument.

During fiscal 2017, Kazia reached two milestones that triggered the conversion of a portion of its Convertible Notes. On September 14, 2016 the directors approved the issue of 20,000,000 ordinary shares as a consequence of a conversion of A$500,000 of the Convertible Notes, and on November 1, 2016 a further 16,000,000 ordinary shares were issued as a result of the conversion of a further portion of the Convertible Notes. During fiscal 2018, one of the noteholders waived his rights to the remaining tranche of convertible notes, resulting in the reduction of the convertible note carrying value by a further A$136,000. As of June 30, 2020, the Convertible Notes carrying value amounts to A$464,000.

C. Research and development, Patents and Licenses, etc.

Expenditure during the research phase of a project is recognized as an expense when incurred. Development costs are capitalized only when technical feasibility studies identify that the project will deliver future economic benefits and these benefits can be measured reliably.

Research and development expenses consist primarily of costs incurred for the development of our product candidates, which include:

| • |  | expenses incurred under agreements with academic research centres, clinical research organizations and investigative sites that conduct our clinical trials; and

| • |  | the cost of acquiring, developing, and manufacturing clinical trial materials.

We cannot determine with certainty the duration and completion costs of the current or future product development, preclinical studies or clinical trials of our product candidates. The duration, costs, and timing of clinical trials and development of our product candidates will depend on a variety of factors, including:

| • |  | the scope, rate of progress, and expense of our ongoing as well as any additional clinical trials and other research and development activities;

| • |  | the countries in which trials are conducted;

| • |  | future clinical trial results;

| • |  | uncertainties in clinical trial enrolment rates or drop-out or discontinuation rates of patients;

| • |  | potential additional safety monitoring or other studies requested by regulatory agencies;

| • |  | significant and changing government regulation; and

| • |  | the timing and receipt of any regulatory approvals.

A change in the outcome of any of these variables with respect to the development of a product candidate could mean a significant change in the costs and timing associated with the development of that product candidate. For example, if the FDA, or another regulatory authority were to require us to conduct clinical trials beyond those that we anticipate will be required to complete clinical development of a product candidate or if we experience significant delays in enrollment in any of our clinical trials, we could be required to expend significant additional financial resources and time on the completion of clinical development.

In fiscal 2020, 2019 and 2018 we spent, respectively, a total of A$9.5 million, A$6.5 million and A$9.8 million on company-sponsored research and development activities. We plan to increase our research and development expenses for the foreseeable future as we continue the development of product candidates and explore further potential applications of our technology.

D. Trend Information

Subject to the risk factors discussed in Item 3D, we have a reasonable expectation that during fiscal 2021:

| • |  | Final results will be reported from the phase II clinical trial of paxalisib in glioblastoma;

| • |  | Final results will be reported from the phase I clinical trial of Cantrixil (TRX-E-002-1) in ovarian cancer;

| • |  | Interim results will be reported from the phase I clinical trial of paxalisib in DIPG at St Jude Children’s Research Hospital;

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| • |  | Interim results will be reported from the phase II clinical trial of paxalisib in HER2+ brain metastases at Dana-Farber Cancer Institute; and

| • |  | Recruitment will commence to the GBM AGILE pivotal study of paxalisib in glioblastoma.

In parallel, the Company continues to actively explore licensing and partnering opportunities with other companies that have the potential to effect further refinements in the scope of the Company’s business.

E. Off-balance sheet arrangements

The Company does not have any off-balance sheet arrangements.

F. Tabular disclosure of contractual obligations

The Company does not have any contractual obligations for future periods as at June 30, 2020.

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Item 6. | Directors, Senior Management and Employees

A. Directors and Senior Management

The names and details of the Company’s Directors and senior management at the date of this report are as follows:

Iain Ross |  | Chairman, Non-Executive Director
Bryce Carmine |  | Non-Executive Director
Steven Coffey |  | Non-Executive Director
James Garner |  | Managing Director, Chief Executive Officer
Kate Hill |  | Company Secretary
Gabrielle Heaton |  | Director of Finance and Administration

Directors were in office for the entire period unless otherwise stated.

Names, titles, experience and expertise

Name: |  | Iain Ross
Title: |  | Chairman, Non-Executive Director
Experience and expertise: |  | Iain, based in the UK, is an experienced Director and has served on a number of Australian company boards. He is Chairman of Redx Pharma plc (LSE:REDX), Silence Therapeutics plc (LON:SLN) and Biomer Technology Limited. In his career he has held senior positions in Sandoz AG, Fisons Plc, Hoffmann-La Roche AG and Celltech Group Plc and also undertaken a number of start-ups and turnarounds on behalf of banks and private equity groups. His track record includes multiple financing transactions having raised in excess of £300 million, both publicly and privately, as well as extensive experience of divestments and strategic restructurings and has over 20 years in cross-border management as a Chairman and CEO. He has led and participated in six four London Stock Exchange (‘LSE’) Initial Public Offerings,(4 LSE, 1 ASX, 1 NASDAQ) and has direct experience of mergers and acquisitions transactions in Europe, USA and the Pacific Rim.
Other current directorships: |  | Redx Pharma plc (LSE:REDX), Silence Therapeutics plc (LON:SLN)
Special responsibilities: |  | Member of Remuneration and Nomination Committee, Member of the Audit, Risk and Governance Committee.
Name: |  | Bryce Carmine
Title: |  | Non-Executive Director
Experience and expertise: |  | Bryce spent 36 years working for Eli Lilly & Co. and retired as Executive Vice President for Eli Lilly & Co, and President, Lilly Bio-Medicines. Prior to this he led the Global Pharmaceutical Sales and Marketing and was a member of the Company’s Executive Committee. Bryce previously held a series of product development portfolio leadership roles culminating when he was named President, Global Pharmaceutical Product Development, with responsibility for the entire late-phase pipeline development across all therapeutic areas for Eli Lilly. During his career with Lilly, Bryce held several country leadership positions including President Eli Lilly Japan, Managing Dir. Australia/NZ & General Manager of a JV for Lilly in Seoul, Korea. Bryce is currently Chairman and CEO of HaemaLogiX Pty Ltd, a Sydney based privately owned biotech.
Other current directorships: |  | None
Special responsibilities: |  | Chair of Remuneration and Nomination Committee, member of Audit, Risk and Governance Committee.

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Name: |  | Steven Coffey
Title: |  | Non-Executive Director
Experience and expertise: |  | Steven is a Chartered Accountant and registered company auditor and has over 35 years experience in the accounting and finance industry. He has been a partner in the chartered accounting firm Watkins Coffey Martin since 1993. He is a Non-executive Director of The Docyard Limited (ASX:TDY) and chairs both the Audit and Risk Committee and the Remuneration Committee for that company. Steven sits on the board of a number of large private family companies and audits a number of large private companies and not-for-profit entities.
Other current directorships: |  | The Docyard Limited (ASX:TDY)
Special responsibilities: |  | Chair of Audit, Risk and Governance Committee, member of Remuneration and Nomination Committee.
Name: |  | Dr. James Garner
Title: |  | Managing Director and Chief Executive Officer
Experience and expertise: |  | Dr Garner is an experienced life sciences executive who has previously worked with companies ranging from small biotechs to multinational pharmaceutical companies such as Biogen and Takeda. His career has focused on regional and global development of new medicines from preclinical to commercialisation. Dr Garner is a physician by training and holds an MBA from the University of Queensland. He began his career in hospital medicine and worked for a number of years as a corporate strategy consultant with Bain & Company before entering the pharmaceutical industry. Prior to joining Kazia in 2016, he led R&D strategy for Sanofi in Asia-Pacific and was based in Singapore.
Other current directorships: |  | None
Special responsibilities: |  | None
Name: |  | Kate Hill
Title: |  | Company Secretary
Experience and expertise: |  | Kate has over 20 years’ experience as an audit partner with Deloitte Touche Tohmatsu, working with ASX listed and privately-owned clients. She has worked extensively in regulated environments including assisting with Initial Public Offerings, capital raising and general compliance, as well as operating in an audit environment. She is a Non-Executive Director of CountPlus Limited (ASX:CUP) and Elmo Software Limited (ASX:ELO) as well as Chair of the Audit and Risk Committee for both of these companies. She is also Chair of Seeing Machines Limited (AIM:SEE). Kate is a member of the Institute of Chartered Accountants in Australia and New Zealand, and a graduate of the Australian Institute of Company Directors.
Name: |  | Gabrielle Heaton
Title: |  | Director of Finance and Administration
Experience and expertise: |  | Gabrielle Heaton has over 30 years of commercial experience in media, property services and healthcare for multinational, ASX listed and overseas companies. She has held a number of senior Finance positions including CFO, Quality Auditor and been responsible for Human Resources and IT. Gabrielle has a Bachelor of Business from the University of Technology and is a member of CPA Australia.

B. Compensation

Principles used to determine the nature and amount of remuneration

Remuneration philosophy

Remuneration for Directors and Senior Executives is based on the overall objective of attracting and retaining people of high quality who will make a worthwhile contribution to the consolidated entity in the short, medium and long term, and thereby contribute to long term shareholder value. The Board and its Remuneration and Nomination Committee take a balanced position between the need to pay market rates to attract talent, and the financial resources of the consolidated entity, in determining remuneration.

Non-Executive Directors remuneration

The Constitution of the consolidated entity and the ASX listing rules specify that the aggregate remuneration of Non-Executive Directors shall be determined from time to time by General Meeting. The last determination for the consolidated entity was at the Annual General Meeting held in October 2005 when the shareholders approved an aggregate remuneration of A$560,000.

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Non-Executive Directors’ fees are reviewed periodically by the Board and are regularly compared with those of companies of comparable market capitalisation and stage of development. The Chairman’s fees are determined independently to the fees of other non-executive Directors based on comparative roles in the external market. The Non-Executive Directors fee structure is a fixed fee model and includes superannuation. Director’s fees for the current financial year have been held at the same level as in the prior financial year.

Executive Directors and other Key Management Personnel (“KMP”)

The Board and the Remuneration and Nomination Committee, in consultation with the Managing Director, have put in place a remuneration structure which provides incentive for employees to drive the activities of the company forward. These arrangements are reviewed annually at the end of the calendar year.

The Board determines an appropriate level of fixed remuneration for the CEO and Group Executives, as well as the proportion of performance-based remuneration.

The executive remuneration and reward framework has three components:

| • |  | fixed remuneration

| • |  | short-term performance incentives - cash bonus

| • |  | share-based payments - award of options through the ESOP

Fixed remuneration is reviewed annually by the Remuneration and Nomination Committee based on individual performance, the overall performance of the consolidated entity and comparable market remunerations. The Remuneration and Nomination Committee approved increases in fixed remuneration during fiscal 2020.

The short-term incentives program is designed to align the targets of the consolidated entity with the performance hurdles of executives. Short-term incentive payments are granted to executives based on specific annual performance objectives, metrics and performance appraisals. Annual performance reviews are conducted at the end of each calendar year and bonuses are paid shortly after the performance reviews are completed. Annual performance objectives cover matters such as progress in clinical trials, and management of the Company’s financial resources.

The Board or the Remuneration and Nomination Committee may, at its discretion, award bonuses for exceptional performance.

The Remuneration and Nomination Committee approved the payment of cash bonuses to the CEO and employees in respect of the financial year ended June 30, 2020.

The long-term incentive comprises equity-based payments. The consolidated entity aims to attract and retain high calibre executives, and align their interests with those of the shareholders, by granting equity-based payments based on tenure. The share-options issued to executives are governed by the ESOP.

Employee share option plan

The Employee Share Option Plan (‘ESOP’) was approved by shareholders in March 2015 and re-approved by shareholders in November 2017.

The ESOP provides for the issue of options to eligible individuals, being employees or Officers of the consolidated entity, however it excludes Non-Executive Directors.

Each option issued under the ESOP entitles its holder to acquire one fully paid ordinary share and is exercisable at a price based on a formula, which includes the weighted average price of such shares at the close of trading on the Australian Securities Exchange for the seven days prior to the date of issue. The number of options offered, the amount payable, the vesting period, the option period, the conditions of exercise or any other factors are at the discretion of the Board of Directors.

The consolidated entity issued 1,450,000 share options under the ESOP during fiscal 2020, of which 1,300,000 were issued to Key Management Personnel.

Any change to the ESOP will require approval by shareholders.

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Use of remuneration consultants

During fiscal 2020, the Company did not engage remuneration consultants.

Details of remuneration

Amounts of remuneration

Details of the remuneration of key management personnel of the consolidated entity are set out in the following tables.

The KMP of the consolidated entity consisted of the following directors of Kazia Therapeutics Limited:

| • |  | Iain Ross - Non-Executive Director, Chairman

| • |  | Bryce Carmine - Non-Executive Director

| • |  | Steven Coffey - Non-Executive Director

| • |  | Dr James Garner - Managing Director, CEO

And the following persons:

| • |  | Gabrielle Heaton - Director of Finance and Administration

| • |  | Kate Hill - Company Secretary

|  | Short-term benefits |  |  |  |  |  | Short-term benefits |  |  | Post- employment benefits |  |  | Share-based payments |  |  |  |
|  |  |  |  |  |  |  | Movements in accrued leave |  |  |  |  |  |  |  |  |  |
|  | Cash salary |  |  | Cash |  |  | Non- |  |  | Super- |  |  | Equity- |  |  |  |
|  | and fees |  |  | Bonus |  |  | monetary |  |  | annuation |  |  | settled options |  |  | Total |
2020 |  | A$ |  |  | A$ |  |  | A$ |  |  | A$ |  |  | A$ |  |  | A$ |
Non-Executive Directors: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
I Ross* |  |  | 135,272 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 135,272 |
B Carmine |  |  | 75,000 |  |  |  | — |  |  |  | — |  |  |  | 7,125 |  |  |  | — |  |  |  | 82,125 |
S Coffey |  |  | 75,000 |  |  |  | — |  |  |  | — |  |  |  | 7,125 |  |  |  | — |  |  |  | 82,125 |
Executive Directors: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
J Garner |  |  | 473,000 |  |  |  | 180,000 |  |  |  | 23,423 |  |  |  | 62,035 |  |  |  | 206,465 |  |  |  | 944,923 |
Other Key Management Personnel: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
G Heaton |  |  | 195,000 |  |  |  | 17,500 |  |  |  | 7,275 |  |  |  | 20,188 |  |  |  | 10,745 |  |  |  | 250,708 |
K Hill |  |  | 127,875 |  |  |  | 15,000 |  |  |  | — |  |  |  | — |  |  |  | 12,826 |  |  |  | 155,701 |
|  |  | 1,081,147 |  |  |  | 212,500 |  |  |  | 30,698 |  |  |  | 96,473 |  |  |  | 230,036 |  |  |  | 1,650,854 |

* | Salary paid in UK pounds, but disclosed in Australian dollars using a conversion rate of 0.5323

The cash bonuses were granted by the Remuneration Committee at a meeting held in November 2019. The amounts were determined on a discretionary basis by the Remuneration Committee after assessing the corporate achievements for fiscal 2019.

Service agreements

Under Remuneration and Nomination Committee policy, employment contracts are entered into with each of the executives who is considered to be KMP. Under the terms of the contracts, remuneration is reviewed at least annually. The employment contracts of KMPs include a termination clause whereby a party can terminate the agreement on notice. Such notice may vary between 4 weeks and 6 months. Under the terms of each contract, payment in lieu can be made by the consolidated entity to substitute the notice period. The consolidated entity may terminate the contracts at any time without cause if serious misconduct has occurred. In the event that employment is terminated for cause, no severance pay or other benefits are payable by the consolidated entity.

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Remuneration and other terms of employment for key management personnel are formalised in service agreements. Details of these agreements are as follows:

Name: Title: Agreement commenced: Term of agreement: Details: |  | James Garner Chief Executive Officer, Managing Director February 1, 2016 Full-time employment Base salary to be reviewed annually by the Remuneration and Nomination Committee. James’s appointment with the consolidated entity may be terminated with the consolidated entity giving 6 months’ notice or by James giving 6 months’ notice. The consolidated entity may elect to pay James equal amount to that proportion of his salary equivalent 6 months’ pay in lieu of notice, together with any outstanding entitlements due to him.
|  | The current base salary, as from January 1, 2020, is A$488,000 including an allowance for health benefits.
Name: Title: Agreement commenced: Term of agreement: Details: |  | Gabrielle Heaton Director of Finance and Administration March 13, 2017 Full time employment Base salary to be reviewed annually by the Remuneration and Nomination Committee. Gabrielle’s appointment with the consolidated entity may be terminated with the consolidated entity giving 4 weeks’ notice or by Gabrielle giving 4 weeks’ notice. The consolidated entity may elect to pay Gabrielle equal amount to that proportion of her salary equivalent 4 weeks’ pay in lieu of notice, together with any outstanding entitlements due to her.
|  | The current base salary, from January 1, 2020, is A$200,000.
Name: Title: Agreement commenced: Term of agreement: Details: |  | Kate Hill Company Secretary September 9, 2016 Part-time contractor Base remuneration is based on time worked. Daily rate to be reviewed annually by the Remuneration and Nomination Committee, with an uplift of 10% on the daily rate applied from January 1, 2019. The contract is open ended. Kate’s appointment with the consolidated entity may be terminated with the consolidated entity giving 60 days’ notice or by Kate giving 60 days’ notice.

Key management personnel have no entitlement to termination payments in the event of removal for misconduct.

Share-based compensation

Issue of shares

The terms and conditions of each grant of options over ordinary shares granted as remuneration to Directors or other Key Management Personnel in this financial year or future financial years are set out below.

The options issued on November 13, 2019 were to James Garner, and represented part of a modification to an earlier tranche of options granted to Dr Garner in early 2016.

The options which were cancelled as part of this modification had the following terms:

| • |  | Initially granted on February 1, 2016

| • |  | 500,000 had a strike price of A$1.988 and were fully vested at the time of the cancellation, expiry February 1, 2021

| • |  | 250,000 had a strike price of A$2.606 and were unvested at the time of the cancellation, expiry February 1, 2021

| • |  | On the date of cancellation, the fair value of the options was de-minimus.

The newly issued options had the following terms:

| • |  | Strike price of A$0.49

| • |  | 50% fully vested at time of grant, the remainder to vest equally over a three-year period starting January 4, 2020

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| • |  | Expiry January 4, 2024

| • |  | Fair value at grant date of A$216,000

The options issued on January 13, 2020 were to Kate Hill (50,000 options, with a fair value at grant date of A$17,000) and Gabrielle Heaton (50,000 options, with a fair value at grant date of A$17,000). Service conditions are that any unvested options are forfeit on cessation of employment. There are no performance conditions, consistent with the Company’s Employee Share Option Plan rules, as reapproved by shareholders on November 15, 2017.

Grant date |  | No of options |  |  | Vesting date |  |  | Exercise date |  |  | Expiry date |  |  | Exercise price $ |  |  | Fair value per option at grant $ |
13/11/2019 |  |  | 600,000 |  |  |  | 13/11/2019 |  |  |  | 13/11/2019 |  |  |  | 04/01/2024 |  |  | $ | 0.49 |  |  | $ | 0.18 |
13/11/2019 |  |  | 200,000 |  |  |  | 04/01/2020 |  |  |  | 04/01/2020 |  |  |  | 04/01/2024 |  |  | $ | 0.49 |  |  | $ | 0.18 |
13/11/2019 |  |  | 200,000 |  |  |  | 04/01/2021 |  |  |  | 04/01/2021 |  |  |  | 04/01/2024 |  |  | $ | 0.49 |  |  | $ | 0.18 |
13/11/2019 |  |  | 200,000 |  |  |  | 04/01/2022 |  |  |  | 04/01/2022 |  |  |  | 04/01/2024 |  |  | $ | 0.49 |  |  | $ | 0.18 |
13/01/2020 |  |  | 25,000 |  |  |  | 13/01/2021 |  |  |  | 13/01/2021 |  |  |  | 13/01/2025 |  |  | $ | 0.88 |  |  | $ | 0.34 |
13/01/2020 |  |  | 25,000 |  |  |  | 13/01/2022 |  |  |  | 13/01/2022 |  |  |  | 13/01/2025 |  |  | $ | 0.88 |  |  | $ | 0.34 |
13/01/2020 |  |  | 25,000 |  |  |  | 13/01/2023 |  |  |  | 13/01/2023 |  |  |  | 13/01/2025 |  |  | $ | 0.88 |  |  | $ | 0.34 |
13/01/2020 |  |  | 25,000 |  |  |  | 13/01/2024 |  |  |  | 13/01/2024 |  |  |  | 13/01/2025 |  |  | $ | 0.88 |  |  | $ | 0.34 |
|  |  | 1,300,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

Options granted carry no dividend or voting rights. Each option is convertible to one ordinary share upon exercise. No options were exercised or lapsed during the year. In all cases of employee options, an option will only vest if the option holder continues to be a full-time employee with the Company or an Associated Company during the vesting period relating to the option.

Pension benefits

The Company paid A$96,473 during fiscal 2020 for employee superannuation benefits and pension benefits related to KMPs.

C. Board Practices

The role of the Board is as follows:

| • |  | representing and serving the interests of shareholders by overseeing and appraising the strategies, policies and performance of the Company. This includes overviewing the financial and human resources the Company has in place to meet its objectives and the review of management performance;

| • |  | protecting and optimising Company performance and building sustainable value for shareholders in accordance with any duties and obligations imposed on the Board by law and the Company’s Constitution and within a framework of prudent and effective controls that enable risk to be assessed and managed;

| • |  | responsible for the overall Corporate Governance of Kazia Therapeutics Limited and its subsidiaries, including monitoring the strategic direction of the Company and those entities, formulating goals for management and monitoring the achievement of those goals;

| • |  | setting, reviewing and ensuring compliance with the Company’s values (including the establishment and observance of high ethical standards); and

| • |  | ensuring shareholders are kept informed of the Company’s performance and major developments affecting its state of affairs.

Responsibilities/functions of the Board include:

| • |  | selecting, appointing and evaluating from time to time the performance of, determining the remuneration of, and planning for the successor of, the CEO;

| • |  | reviewing procedures in place for appointment of senior management and monitoring of its performance, and for succession planning. This includes ratifying the appointment and the removal of the Company Secretary;

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| • |  | overseeing the Company, including its control and accountability systems;

| • |  | input into and final approval of management development of corporate strategy, including setting performance objectives and approving operating budgets;

| • |  | reviewing and guiding systems of risk management and internal control and ethical and legal compliance. This includes reviewing procedures in place to identify the main risks associated with the Company’s businesses and the implementation of appropriate systems to manage these risks;

| • |  | overseeing and monitoring compliance with the Code of Conduct and other corporate governance policies;

| • |  | monitoring corporate performance and implementation of strategy and policy;

| • |  | approving major capital expenditure, acquisitions and divestitures, and monitoring capital management;

| • |  | monitoring and reviewing management processes in place aimed at ensuring the integrity of financial and other reporting;

| • |  | monitoring and reviewing policies and processes in place relating to occupational health and safety, compliance with laws, and the maintenance of high ethical standards; and

| • |  | performing such other functions as are prescribed by law or are assigned to the Board.

In carrying out its responsibilities and functions, the Board may delegate any of its powers to a Board committee, a director, employee or other person subject to ultimate responsibility of the directors under the Australian Corporations Act 2001.

Matters which are specifically reserved for the Board or its committees include the following:

| • |  | appointment of a Chair;

| • |  | appointment and removal of the CEO;

| • |  | appointment of directors to fill a vacancy or as additional directors;

| • |  | establishment of Board committees, their membership and delegated authorities;

| • |  | approval of dividends;

| • |  | development and review of corporate governance principles and policies;

| • |  | approval of major capital expenditure, acquisitions and divestitures in excess of authority levels delegated to management;

| • |  | calling of meetings of shareholders; and

| • |  | any other specific matters nominated by the Board from time to time.

Structure of the Board

The Company’s Constitution governs the regulation of meetings and proceedings of the Board. The Board determines its size and composition, subject to the terms of the Constitution. The Board does not believe that it should establish a limit on tenure other than stipulated in the Company Constitution (refer to ‘Term of Directors’ below).

While tenure limits can help to ensure that there are fresh ideas and viewpoints available to the Board, they hold the disadvantage of losing the contribution of directors who have been able to develop, over a period of time, increasing insight in the Company and its operation and, therefore, an increasing contribution to the Board as a whole. It is intended that the Board should comprise a majority of independent non-executive directors and comprise directors with a broad range of skills, expertise and experience from a diverse range of backgrounds. The Board regularly reviews the independence of each director in light of the interests disclosed to the Board.

The Board only considers directors to be independent where they are independent of management and free of any business or other relationship that could materially interfere with, or could reasonably be perceived to interfere with, the exercise of their unfettered and independent judgment. The Board has adopted a definition of independence based on that set out in Principle 2.3 of the ASX Corporate Governance Principles and Recommendations (4th edition). The Board will review the independence of each director in light of interests disclosed to the Board from time to time. In accordance with the definition of independence above, and the materiality thresholds set, the Board considers Bryce Carmine, Iain Ross and Steven Coffey to be independent directors.

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There are procedures in place, agreed by the Board, to enable directors in furtherance of their duties to seek independent professional advice at the Company’s expense. The appointment and expiration dates of each director in office at the date of this report is as follows:

Name |  | Position |  | Year First Appointed |  | Current term expires
Bryce Carmine |  | Non-executive Director |  | 2015 |  | Nov-20
Iain Ross |  | Non-executive Director, Chairman |  | 2014 |  | Nov-21
Steven Coffey |  | Non-executive Director |  | 2012 |  | Nov-22
James Garner |  | Managing director, CEO |  | 2016 |  | N/A*

* | The managing director is exempt from standing for re-election under the Company’s constitution and Australian corporate law.

Further details on each director can be found in “Names, titles, experience and expertise” above.

Term of Directors

The Company’s Constitution requires that at each Annual General Meeting of the Company, one third (or the number nearest to but not exceeding one third) of the directors, (excluding a director who is the Managing Director, and a director appointed to fill a casual vacancy) must retire from office provided that no director may retain office for more than three years without offering himself/herself for re-election even though such submission results in more than one third of the directors retiring from office.

The Board of Directors has the power to appoint any person to be a director either to fill a casual vacancy or as an additional director (up to a maximum of 10). Any director so appointed may hold office only until the next Annual General Meeting when he or she shall be eligible for election by the Company shareholders.

Board of Directors

The Board of Kazia Limited is elected by and accountable to shareholders. The Board monitors and directs the business and is responsible for the corporate governance of the Company. As at June 30, 2020, the Board comprised of four directors, three of whom were non-executive directors.

Committees

The Board has established an Audit, Risk and Governance Committee and a Remuneration and Nomination Committee.

Audit, Risk and Governance Committee

The Board has established an Audit, Risk and Governance Committee which operates under a Charter approved by the Board, which is available on the Company’s website. It is the Board’s responsibility to ensure that an effective internal control framework exists within the entity. This includes internal controls to deal with both the effectiveness and efficiency of significant business processes, the safeguarding of assets, the maintenance of proper accounting records, and the reliability of financial information as well as non-financial considerations such as the benchmarking of operational key performance indicators. The Board has delegated responsibility for establishing and maintaining a framework of internal control and ethical standards to the Audit, Risk and Governance Committee.

The Committee also provides the Board with additional assurance regarding the reliability of financial information for inclusion in the financial reports.

Members of the Audit, Risk and Governance Committee are Steven Coffey (Chairman), Bryce Carmine and Iain Ross, each of whom is an independent director.

Remuneration and Nomination Committee

The purpose of the Remuneration and Nomination Committee is to assist and advise the Board to develop, implement and, from time to time, update policies in relation to:

| • |  | the selection, nomination and appointment processes for directors; and

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| • |  | the remuneration of key management personnel and directors.

This committee is accountable to the Board for its performance and is subject to an annual review by the Board. Members of the Remuneration and Nomination Committee are Bryce Carmine (Chairman), Steven Coffey and Iain Ross, each of whom is an independent director.

Performance

The performance of the Board and key executives is reviewed regularly using both measurable and qualitative indicators.

On an annual basis, directors will provide written feedback in relation to the performance of the Board and its Committees against a set of agreed criteria:

| • |  | each Committee of the Board will also be required to provide feedback in terms of a review of its own performance;

| • |  | feedback will be collected by the chair of the Board, or an external facilitator, and discussed by the Board, with consideration being given as to whether any steps should be taken to improve performance of the Board or its Committees;

| • |  | the Chief Executive Officer will also provide feedback from senior management in connection with any issues that may be relevant in the context of Board performance review; and

| • |  | where appropriate to facilitate the review process, assistance may be obtained from third party advisors.

Remuneration

It is the Company’s objective to provide maximum shareholder benefit from the retention of a high-quality Board and executive team by remunerating directors and key executives fairly and appropriately with reference to relevant employment market conditions. To assist in achieving this objective, the Board, in assuming the responsibilities of assessing remuneration to employees, links the nature and amount of executive directors’ and officers’ remuneration to the Company and Company’s financial and operational performance.

The expected outcomes of the remuneration structure are:

| • |  | retention and motivation of key executives;

| • |  | attraction of high-quality management to the Company and Company; and

| • |  | performance incentives that allow executives to share in the success of Kazia Therapeutics Limited.

For a more comprehensive explanation of the Company’s remuneration framework and the remuneration received by directors and key executives in the current period, please refer to the section “Compensation” above.

There is no plan to provide retirement benefits to executive or non-executive directors, except for the Australian Government Superannuation Guarantee.

The Remuneration and Nomination Committee is responsible for determining and reviewing compensation arrangements for the directors themselves and the Chief Executive Officer and executive team.

D. Employees

As of the end of each of the last three fiscal years, the Company employed the following number of people - FTEs:

Category of Activity |  | 2020 |  |  | 2019 |  |  | 2018 |
Research and Development |  |  | 3.6 |  |  |  | 3.6 |  |  |  | 3.6 |
Finance and Administration |  |  | 1.7 |  |  |  | 1.7 |  |  |  | 1.7 |
Total |  |  | 5.3 |  |  |  | 5.3 |  |  |  | 5.3 |
Geographic Location |  | 2020 |  |  | 2019 |  |  | 2018 |
Australia |  |  | 5.3 |  |  |  | 5.3 |  |  |  | 5.3 |
United States |  |  | 0 |  |  |  | 0 |  |  |  | 0 |
Total |  |  | 5.3 |  |  |  | 5.3 |  |  |  | 5.3 |

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E. Share Ownership

Directors’ and KMP interests in the shares and options of the Company for fiscal 2020:

Shareholding

The number of shares in the Company held during fiscal 2020 by each Director and other members of Key Management Personnel of the Company, including their personally related parties, is set out below:

|  | Balance at start of year |  |  | Received as part of rem |  |  | Additions |  |  | Disposals |  |  | Balance at end of year |
Ordinary shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
B Carmine* |  |  | 131,293 |  |  |  | — |  |  |  | 135,000 |  |  |  | — |  |  |  | 266,293 |
S Coffey* |  |  | 181,474 |  |  |  | — |  |  |  | 145,000 |  |  |  | — |  |  |  | 326,474 |
J Garner* |  |  | 110,000 |  |  |  | — |  |  |  | 165,000 |  |  |  | — |  |  |  | 275,000 |
I Ross* |  |  | 475,001 |  |  |  | — |  |  |  | 325,000 |  |  |  | — |  |  |  | 800,001 |
K Hill* |  |  | 30,000 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 30,000 |
G Heaton |  |  | — |  |  |  | — |  |  |  | 10,000 |  |  |  | — |  |  |  | 10,000 |
Total |  |  | 927,768 |  |  |  | — |  |  |  | 780,000 |  |  |  | — |  |  |  | 1,707,768 |

* | Each Director and Key Management Personnel owns less than 1% of shareholding.

Option holding

The number of options over ordinary shares in the Company held during fiscal 2020 by each Director and other members of Key Management Personnel of the Company, including their personally related parties, is set out below:

|  | Balance at start of year |  |  | Granted as part of rem |  |  | Expired |  |  | Cancelled as part of modification |  |  | Balance at end of year |
Ordinary shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
S Coffey* |  |  | 5,875 |  |  |  | — |  |  |  | (5,875 | ) |  |  | — |  |  |  | — |
J Garner**,*** |  |  | 750,000 |  |  |  | 1,200,000 |  |  |  |  |  |  |  | (750,000 | ) |  |  | 1,200,000 |
K Hill** |  |  | 270,000 |  |  |  | 50,000 |  |  |  |  |  |  |  | — |  |  |  | 320,000 |
G Heaton ** |  |  | 192,000 |  |  |  | 50,000 |  |  |  |  |  |  |  | — |  |  |  | 242,000 |
Total |  |  | 1,217,875 |  |  |  | 1,300,000 |  |  |  | (5,875 | ) |  |  | (750,000 | ) |  |  | 1,762,000 |

* | The above listed options were not issued as part of remuneration.

** | Options issued under the Employee Share Option Plan. Unvested options are forfeited upon cessation of employment with the Company.

*** | The previously issued 750,000 options were cancelled and 1,200,000 new options issued. These transactions together have been accounted for as a modification.

The granted options were issued as part of remuneration and under the Employee Share Option Plan. Unvested options are forfeited upon cessation of employment with the Company.

Share-based compensation

There were no shares issued to Directors or other KMP as part of compensation during fiscal 2020.

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Item 7. | Major Shareholders and Related Party Transactions

A. Major shareholders

The following table present certain information regarding the beneficial ownership of our ordinary shares based on 94,623,369 ordinary shares outstanding at October 14, 2020, by each person known by us to be the beneficial owner of more than 5% of our ordinary shares, as well as their holdings on August 31, 2019 and August 31, 2018.

|  | Ordinary shares beneficially owned |
5% or greater shareholders |  | October 14, 2020 |  |  | August 31, 2019 |  |  | August 31, 2018 |
|  | Number |  |  | % |  |  | Number |  |  | % |  |  | Number |  |  | % |
Hishenk Pty Limited and associated entities |  |  | 18,570,000 |  |  |  | 16.1 | % |  |  | 11,108,792 |  |  |  | 17.9 | % |  |  | 6,684,914 |  |  |  | 13.8 | %
Platinum International Healthcare Fund |  |  | 11,356,760 |  |  |  | 9.9 | % |  |  | 6,578,948 |  |  |  | 10.6 | % |  |  | — |  |  |  | 0.0 | %
Quest Asset Partners Pty Ltd |  |  | 7,215,790 |  |  |  | 6.3 | % |  |  | — |  |  |  | 0.0 | % |  |  | — |  |  |  | 0.0 | %

At October 12, 2020, there were 3,130,299 of the Company’s ADSs outstanding, representing 31,302,996 ordinary shares (or 27.1% of the then outstanding ordinary shares). At October 12, 2020, there were 52 registered holders of the Company’s ADSs. On that same date, 100 ordinary shares were held directly by U.S. holders.

There have been no other significant shareholders in the last three fiscal years. All shareholders have the same voting rights.

B. Related party transactions

During fiscal 2020, and up to the date of this report, we did not enter into any transactions or loans with any: (i) enterprises that directly or indirectly, through one or more intermediaries, control, are controlled by or are under common control with us; (ii) associates; (iii) individuals owning, directly or indirectly, an interest in our voting power that gives them significant influence over us, and close members of any such individual’s family; (iv) executive officers and close members of such individuals’ families; or (v) enterprises in which a substantial interest in our voting power is owned, directly or indirectly, by any person described in (iii) or (iv) or over which such person is able to exercise significant influence.

Transactions between related parties, when they occur, are on normal commercial terms and the conditions no more favorable than those available to other non-related parties.

C. Interests of Experts and Counsel

Not applicable

Item 8. | Financial Information

A. Consolidated Statements and Other Financial Information

Consolidated financial statements are included in Item 18. “Financial Statements” commencing on page F-1.

Legal proceedings

The consolidated entity is continuing to prosecute its Intellectual Property (‘IP’) rights against an Austrian company, APOtrend. In June 2019 the Austrian Supreme Court rendered a final decision on the patent infringement. As a result, Kazia is entitled to make a claim against APOtrend in relation to two of the three products which were the subject of the claim, while for the third product, Kazia’s claim was denied. In respect of this third product, APOtrend is entitled to claim compensation for damages caused by a preliminary injunction. At the date of this report, no claim has been made by either party. Kazia is entitled to access APOtrend’s books to calculate a license fee/other payment claims against APOtrend. Kazia is currently trying to enforce this right in court. The consolidated entity has provided a guarantee to the value of €250,000 ($409,098) with the court to provide a security for potential damage claims raised by APOtrend (which is not limited to this amount, however). As at 30 June 2020, the receivable balance continues to be fully impaired on the basis that it is unlikely to be recovered.

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Dividends

There were no dividends paid, recommended or declared during fiscal years 2020, 2019 or 2018.

B. Significant Changes

No significant change has occurred since the date of the annual financial statements included in this Annual Report on Form 20-F.

Item 9. | The Offer and Listing

A. Offer and listing details

See Item 9C for more information.

B. Plan of Distribution

Not applicable

C. Markets

Kazia’s principal listing exchange and the exchange upon which its ordinary shares are quoted is the Australian Securities Exchange (“ASX”). The trading symbol on ASX is ‘KZA’.

Kazia’s ordinary shares trade in the U.S. in the form of ADSs on the NASDAQ Capital Market. Each ADS represents 10 ordinary shares of Kazia. The trading symbol on the NASDAQ Capital Market is ‘KZIA’. Kazia has entered into a Deposit Agreement with The Bank of New York Mellon under which the Bank of New York, acting as depositary, issues the ADSs.

D. Selling Shareholders

Not applicable

E. Dilution

Not applicable

F. Expenses of the issue

Not applicable

Item 10. | Additional Information

A. Share Capital

Not applicable

B. Memorandum and Articles of Association

Our Constitution is similar in nature to the bylaws of a U.S. corporation. It does not provide for or prescribe any specific objectives or purposes of Kazia. Our Constitution is subject to the terms of the ASX Listing Rules and the Corporations Act. It may be amended or repealed and replaced by special resolution of shareholders, passed by at least 75% of the votes cast by shareholders entitled to vote on the resolution.

Under Australian law, a company has the legal capacity and powers of an individual both within and outside Australia. The material provisions of our Constitution are summarized below. This summary is not intended to be complete nor to constitute a definitive statement of the rights and liabilities of our shareholders, and is qualified in its entirety by reference to the complete text of our Constitution, a copy of which is incorporated by reference as Exhibit 1.1 to this Annual Report.

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Interested Directors

Subject to the Corporations Act and the ASX Listing Rules, neither a director nor that director’s alternate may vote in respect of any contract or arrangement in which the director has, directly or indirectly, any material interest according to our Constitution. However, that director may execute or otherwise act in respect of that contract or arrangement notwithstanding any material personal interest. Unless a relevant exception applies, the Corporations Act requires our directors to provide disclosure of any material personal interest, and prohibits directors from voting on matters in which they have a material personal interest or being present while such matter is being considered at the board meeting. In addition, the Corporations Act and the ASX Listing Rules require shareholder approval of any provision of related party benefits to our directors.

Directors compensation

Our directors are paid remuneration for their services as directors (but excluding any remuneration payable to a director under any executive services contract with us or one of our related bodies corporate) which is determined in a general meeting of shareholders. The aggregate, fixed sum for directors’ remuneration is to be divided among the directors in such proportion as the directors themselves agree and in accordance with our Constitution. The fixed sum remuneration for directors may not be increased except at a general meeting of shareholders and the particulars of the proposed increase are required to have been provided to shareholders in the notice convening the meeting. In addition, executive directors may be paid remuneration as determined by the directors from time to time and, subject to the ASX Listing Rules, including as a salary, commission or participation in profits and/or by the issue of shares, options to acquire shares or performance rights or other incentives (or a combination of any of these methods of remuneration).

Fees payable to our non-executive directors must be by way of a fixed sum and not by way of a commission on or a percentage of profits or operating revenue. Remuneration paid to our executive directors must also not include a commission or percentage of operating revenue.

Pursuant to our Constitution, if, at our board’s request, any director performs extra services or makes special exertions, Kazia may remunerate that director by paying for those services and exertions.

In addition to other remuneration provided in our Constitution, all of our directors are entitled to be paid by us for all other travelling, accommodation and other expenses incurred by the directors in attending and returning from general meetings, board meetings, committee meetings or otherwise in connection with our business.

Borrowing powers exercisable by Directors

Pursuant to our Constitution, the management and control of our business affairs are vested in our board of directors. Our board of directors has the power to raise or borrow money or obtain other financial accommodation for Company purposes, and may grant security for the repayment of that sum or sums or the payment, performance or fulfilment of any debts, liabilities, contracts or obligations incurred or undertaken by the Company in any manner and on any terms and conditions as our board thinks fit.

Retirement of Directors

Pursuant to our Constitution and the ASX Listing Rules, at least one director, other than the Managing Director, must retire from office at every annual general meeting unless there has been an election of directors earlier that year. A director, other than the director who is the Managing Director, must retire from office at the conclusion of three years or following the third annual general meeting after which the director was elected, whichever is longer. If no director is required to retire at an annual general meeting, then the director to retire will be the director who has been longest in office since last being elected. Retired directors are eligible for a re-election to the board of directors unless disqualified from acting as a director under the Corporations Act or our Constitution.

Rights and restrictions on classes of shares

The rights attaching to our ordinary shares are detailed in our Constitution. Our Constitution provides that our directors may issue shares with any preferential, deferred or special rights, privileges or conditions or with any restriction (whether in relation to dividends, voting, return of share capital or otherwise) as our board of directors may determine. Subject to any approval which is required from our shareholders under the Corporations Act and the ASX Listing Rules, we may issue further shares on such terms and conditions as our board of directors resolves.

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Dividend rights

Our board of directors may from time to time determine to pay and declare dividends to shareholders. All dividends unclaimed for one year after having been declared may be invested or otherwise made use of by our board of directors for our benefit until claimed or otherwise disposed of in accordance with our Constitution.

Voting rights

Under our Constitution, and subject to any voting exclusions imposed under the ASX Listing Rules (which typically exclude parties from voting on resolutions in which they have an interest), the rights and restrictions attaching to a class of shares, each shareholder has one vote on a show of hands at a meeting of the shareholders unless a poll is demanded under the Constitution or the Corporations Act. On a poll vote, each shareholder shall have one vote for each fully paid share and a fractional vote for each share held by that shareholder that is not fully paid, such fraction being equivalent to the proportion of the amount that has been paid to such date on that share. Shareholders may vote in person or by proxy, attorney or representative. Under Australian law, shareholders of a public company are generally not permitted to approve corporate matters by written consent. Our Constitution does not provide for cumulative voting. Note that ADS holders may not directly vote at a meeting of the shareholders but may instruct the depositary to vote the number of deposited ordinary shares their ADSs represent.

Right to share in our profits

Pursuant to our Constitution, our shareholders are entitled to participate in our profits only by payment of dividends. Our board of directors may from time to time determine to pay dividends to the shareholders; however, no dividend is payable except in accordance with the thresholds set out in the Corporations Act.

Rights to share in the surplus in the event of winding up

Our Constitution provides for the right of shareholders to participate in a surplus in the event of our winding up, subject to the rights attaching to a class of shares, the Constitution, the Corporations Act and the ASX Listing Rules.

No redemption provision for ordinary shares

There are no redemption provisions in our Constitution in relation to ordinary shares. Under our Constitution, any preference shares may be issued on the terms that they are, or may at the option of Kazia or the holder be, liable to be redeemed or converted into ordinary shares.

Variation or cancellation of share rights

Subject to the Corporations Act, the ASX Listing Rules and the terms of issue of shares of that class, the rights attached to shares in a class of shares may only be varied or cancelled by either:

| • |  | a special resolution passed at a meeting of members holding shares in that class; or

| • |  | the written consent of members with at least 75% of the shares in that class.

Directors may make calls

Our Constitution provides that our directors may make calls on a shareholder for all monies unpaid on shares held by that shareholder, other than monies payable at fixed times under the conditions of allotment.

General Meetings of Shareholders

General meetings of shareholders may be called by our board of directors. Except as permitted under the Corporations Act, shareholders may not convene a meeting. The Corporations Act requires the directors to call and arrange to hold a general meeting on the request of shareholders with at least 5% of the votes that may be cast at a general meeting. Notice of the proposed meeting of our shareholders is required at least 28 days prior to such meeting under the Corporations Act.

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Foreign Ownership Regulation

Our Constitution does not impose specific limitations on the rights of non-residents to own securities. However, acquisitions and proposed acquisitions of securities in Australian companies may be subject to review and approval by the Australian Federal Treasurer under the Foreign Acquisitions and Takeovers Act 1975 (Cth) (the “Foreign Takeovers Act”), which generally applies to acquisitions or proposed acquisitions:

| • |  | by a foreign person (as defined in the Foreign Takeovers Act) or associated foreign persons that would result in such persons having an interest in 20% or more of the issued shares of, or control of 20% or more of the voting power in, an Australian company; and

| • |  | by non-associated foreign persons that would result in such foreign persons having an aggregate interest in 40% or more of the issued shares of, or control of 40% or more of the voting power in, an Australian company, where the Australian company is valued above the monetary threshold prescribed by Foreign Takeovers Act.

However, in general terms, no such review or approval under the Foreign Takeovers Act is required if the foreign acquirer is a U.S. entity or an entity from certain other countries and the value of the target is less than A$1,154 million, unless the company operates in certain sensitive industries. Exemptions do not apply to investments by foreign governments and their associated entities.

The Australian Federal Treasurer may prevent a proposed acquisition in the above categories or impose conditions on such acquisition if the Treasurer is satisfied that the acquisition would be contrary to the national interest. If a foreign person acquires shares or an interest in shares in an Australian company in contravention of the Foreign Takeovers Act, the Australian Federal Treasurer may make a range of orders including an order the divestiture of such person’s shares or interest in shares in that Australian company.

Ownership Threshold

There are no specific provisions in our Constitution that require a shareholder to disclose ownership above a certain threshold. The Corporations Act, however, requires a shareholder to notify us and the ASX once it, together with its associates, acquires a 5% interest in our ordinary shares, at which point the shareholder will be considered to be a “substantial” shareholder. Further, once a shareholder owns (alone or together with associates) a 5% interest in us, such shareholder must notify us and the ASX of any increase or decrease of 1% or more in its holding of our ordinary shares, and must also notify us and the ASX on its ceasing to be a “substantial” shareholder. As we are also a U.S. public company, our shareholders are also subject to disclosure requirements under U.S. securities laws.

Issues of Shares and Change in Capital

Subject to our Constitution, the Corporations Act, the ASX Listing Rules and any other applicable law, we may at any time issue shares and give any person a call or option over any shares on any terms, with preferential, deferred or special rights, privileges or conditions or with any restrictions and for the consideration and other terms that the directors determine.

Subject to the requirements of our Constitution, the Corporations Act, the ASX Listing Rules and any other applicable law, including relevant shareholder approvals, we may consolidate or divide our share capital into a larger or smaller number by resolution, reduce our share capital in any manner (provided that the reduction is fair and reasonable to our shareholders as a whole, does not materially prejudice our ability to pay creditors and obtains the necessary shareholder approval) or buy back our ordinary shares whether under an equal access buy-back or on a selective basis.

Change of Control

Takeovers of listed Australian public companies, such as Kazia, are regulated by the Corporations Act, which prohibits the acquisition of a “relevant interest” in issued voting shares in a listed company if the acquisition will lead to that person’s or someone else’s “voting power” (being the person’s relevant interests plus those of its associates) in Kazia’s issued shares increasing from 20% or below to more than 20% or increasing from a starting point that is above 20% and below 90% (“Takeovers Prohibition”), subject to a range of exceptions.

Generally, a person will have a relevant interest in securities if the person:

| • |  | is the holder of the securities or the holder of an ADS over the shares;

| • |  | has power to exercise, or control the exercise of, a right to vote attached to the securities; or

| • |  | has the power to dispose of, or control the exercise of a power to dispose of, the securities, including any indirect or direct power or control.

If, at a particular time:

| • |  | a person has a relevant interest in issued securities; and

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| • |  | the person has:

| • |  | entered or enters into an agreement with another person with respect to the securities;

| • |  | given or gives another person an enforceable right, or has been or is given an enforceable right by another person, in relation to the securities (whether the right is enforceable presently or in the future and whether or not on the fulfillment of a condition); or

| • |  | granted or grants an option to, or has been or is granted an option by, another person with respect to the securities; and

| • |  | the other person would have a relevant interest in the securities if the agreement were performed, the right enforced or the option exercised,

Then the other person is taken to already have a relevant interest in the securities.

There are a number of exceptions to the Takeovers Prohibition on acquiring a relevant interest in issued voting shares above 20%. In general terms, some of the more significant exceptions include:

| • |  | when the acquisition results from the acceptance of an offer under a formal takeover bid;

| • |  | when the acquisition is conducted on market by or on behalf of the bidder during the bid period for a full takeover bid that is unconditional or only conditional on certain ‘prescribed’ matters set out in the Corporations Act,

| • |  | when the acquisition has been previously approved by shareholders of Kazia by resolution passed at general meeting;

| • |  | an acquisition by a person if, throughout the six months before the acquisition, that person or any other person has had voting power in Kazia of at least 19% and, as a result of the acquisition, none of the relevant persons would have voting power in Kazia more than three percentage points higher than they had six months before the acquisition;

| • |  | when the acquisition results from the issue of securities under a pro rata rights issue;

| • |  | when the acquisition results from the issue of securities under a dividend reinvestment scheme or bonus share plan;

| • |  | when the acquisition results from the issue of securities under certain underwriting arrangements;

| • |  | when the acquisition results from the issue of securities through a will or through operation of law;

| • |  | an acquisition that arises through the acquisition of a relevant interest in another listed company which is listed on a prescribed financial market or a foreign market approved by ASIC;

| • |  | an acquisition arising from an auction of forfeited shares conducted on-market; or

| • |  | an acquisition arising through a compromise, arrangement, liquidation or buy-back.

Breaches of the takeovers provisions of the Corporations Act are criminal offenses. The Australian Securities and Investments Commission, or ASIC, and the Australian Takeover Panel have a wide range of powers relating to breaches of takeover provisions or other circumstances deemed to be unacceptable (whether or not they involve a breach of the takeover provisions), including the ability to make orders canceling contracts, freezing transfers of, and rights attached to, securities, and forcing a party to dispose of securities. There are certain defenses to breaches of the takeover provisions provided in the Corporations Act.

Access to and Inspection of Documents

Inspection of our records is governed by the Corporations Act. Any member of the public has the right to inspect or obtain copies of our registers on the payment of a prescribed fee. Shareholders are not required to pay a fee for inspection of our registers or minute books of the meetings of shareholders. Other corporate records, including minutes of directors’ meetings, financial records and other documents, are not open for inspection by shareholders. Where a shareholder is acting in good faith and an inspection is deemed to be made for a proper purpose, a shareholder may apply to the court to make an order for inspection of our books.

C. Material contracts

License Agreement with Genentech Inc.

In October 2016, the Company entered into a worldwide licensing agreement with Genentech, a member of the Roche Group, to develop and commercialise GDC-0084, a small molecule inhibitor of the phosphoinositide-3-kinase (PI3K) pathway. Under the terms of the agreement, the Company paid Genentech an upfront payment of US$5 million. In addition, the terms of the agreement call for performance-related consideration linked to regulatory and commercial outcomes and royalty payments in-line with industry benchmarks.

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Acquisition of Glioblast Pty Ltd—Share Sale Agreement with Kilinwata Investments Pty. Ltd., Mi Ok Chong and Paul Hopper

In October 2016, the Company acquired 100% of the issued shares of Glioblast Pty Ltd, a privately-held, neuro-oncology-focused Australian biotechnology company. The transaction included an upfront payment of A$2.1 million, comprising A$600,000 in cash and ordinary fully-paid shares valued at A$1.5 million, with the actual number of shares determined on the basis of the volume-weighted average price of the Company’s shares on the ASX in the seven days prior to this announcement. The shareholders of Glioblast will be eligible for further payments in cash or equity on the achievement of performance related milestones. The first two of these milestones provide for the issue of ordinary fully-paid shares valued at A$1.25 million respectively on commencement and successful completion of a phase II clinical trial of GDC-0084, with the actual number of shares determined on the basis of the volume-weighted average price of the Company’s shares on the ASX in the seven days prior to satisfaction of the relevant milestone being announced. A further two milestones may trigger payments in cash or equity at the Company’s sole discretion. Any issue of equity in the Company will be subject to a minimum six-month escrow period.

Convertible Note Deed Poll and Amendment

On December 4, 2014, we and Triaxial signed a Convertible Note Deed Poll (‘Deed’) which superseded a Loan Agreement. The Deed extinguishes the liability created by the Loan Agreement, which previously allowed for a cash settlement and now allows Triaxial to convert their debt into ordinary shares, provided that the Company achieves defined milestones established in the schedule of the Deed. Accordingly, the convertible note has been reclassified as an equity instrument rather than debt instrument.

During the fiscal 2017, the Company reached two milestones triggering the conversion of a portion of its convertible note as follows;

| • |  | On August 11, 2016 the Company announced the submission of an IND application. On September 10, 2016, the Company received a letter from the FDA advising the study may proceed. This triggered the conversion of Convertible Notes with a face value of A$500,000 into 20,000,000 ordinary shares.

| • |  | on October 31, 2016, the Company announced it had licensed a Phase II ready molecule. This triggered the conversion of Convertible Notes with a face value of A$400,000 into 16,000,000 ordinary shares.

During fiscal 2018, A$136,000 of the Convertible Notes was extinguished. The remaining Convertible Notes with a face value of A$464,000 at year end may be converted into 1,856,000 ordinary shares of the Company (post share consolidation).

The remaining portion of the convertible note will be exercised at the holders’ discretion on completion of Phase II clinical trial or achieving “Breakthrough Designation”. Completion will be deemed to occur upon the receipt by the Company of a signed study report or notification of the designation. There is a possibility for an early conversion of the Convertible Notes if a third party acquires more than 50% of the issued capital of the Company.

Clinical Trial Collaboration and Supply Agreement with the Global Coalition for Adaptive Research

In October 2020, the Company entered into a Clinical Trial Collaboration and Supply Agreement with the Global Coalition for Adaptive Research (GCAR), a US-based 501(C)(3) non-profit organisation. The agreement relates to the inclusion of Kazia’s investigational new drug, paxalisib (GDC-0084) in a phase II/III adaptive clinical trial known as GBM AGILE (NCT03970447), which is expected to serve as the pivotal study for registration of paxalisib in glioblastoma by the US Food and Drug Administration (FDA). Under the terms of the agreement, the Company paid GCAR an upfront payment of US$ 5 million on execution, and will make further payments to GCAR throughout the course of the study, as defined milestones are met, with the total cost of the study capped at a pre-defined amount under the terms of the agreement. GCAR will serve as the sponsor of GBM AGILE and the company will supply investigational product for conduct of the study at its sole expense. It is expected that paxalisib’s participation in GBM AGILE will be approximately three to four years in duration.

D. Exchange controls

Australia has largely abolished exchange controls on investment transactions. The Australian dollar is freely convertible into U.S. dollars. In addition, (other than as specified under “taxation” below and certain restrictions imposed under Australian law in relation to dealings with the assets of and transactions with, designated countries, entities and persons specified by the Australian Government Department of Foreign Affairs and Trade from time to time, including, persons connected with terrorism) there are currently no specific rules or limitations regarding the export from Australia of profits, dividends, capital, or similar funds belonging to foreign investors, except that certain payments to non-residents must be reported to the Australian Transaction Reports and Analysis Centre, which monitors such transactions.

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Under Australian law, foreign persons require the approval from the Australian Treasurer to acquire more than a limited percentage of the interests in an Australian company. These limitations are set forth in the Australian Foreign Acquisitions and Takeovers Act 1975 (Cth) (the “Foreign Takeovers Act”).

Under the Foreign Takeovers Act, in general terms, the approval of the Australian Treasurer is required for any foreign person (either alone or together with any one or more of its associates) to acquire an interest of 20% or more of the voting power (including potential voting power) or issued shares (including rights to issued shares) (“Substantial Interest”) in an Australian entity, whose total issued securities value or total asset value (whichever is higher) exceed A$275 million. If the person is a U.S. investor, the A$275 million threshold applies only for investments in prescribed sensitive sectors, otherwise a threshold of A$1,192 million rather than A$275 million applies. All direct investment by foreign governments and their related entities regardless of the value of the investment, including proposals to establish new businesses, must be notified to the Australian Treasurer. Where an acquisition is made in breach of these requirements, the Australian Treasurer may make a range of orders including an order requiring the acquirer to dispose of its Substantial Interest within a specified period of time.

In addition, if a foreign person acquires a Substantial Interest in Kazia in circumstances where the above monetary thresholds would be exceeded and as a result the total holdings of all foreign persons and their associates exceeds 40% in aggregate without the approval of the Australian Treasurer, then the Australian Treasurer may make a range of orders including an order requiring the acquirer to dispose of its Substantial Interest within a specified period of time. The same rule applies if the total holdings of all foreign persons and their associates already exceeds 40% and a foreign person (or its associate) acquires any further interests, including in the course of trading in the secondary market of the ADSs.

Under the current Australian foreign investment policy, the Australian Treasurer has the power to make such an order in relation to an acquisition that contravenes the Foreign Takeovers Act where the level of foreign ownership exceeds 40% in the ordinary course of trading, if the Australian Treasurer is satisfied that the acquisition is contrary to the national interest. The Foreign Takeovers Act allows foreign persons to seek prior approval of acquisitions of Kazia interests which could otherwise result in the Australian Treasurer making an order requiring the foreign person to dispose of any Substantial Interest.

If a foreign person holds more than 20% of the interests of Kazia or if the level of aggregate foreign ownership of Kazia exceeds 40% at any time, Kazia would be considered a foreign person under the Foreign Takeovers Act. In such event, Kazia would be required to obtain the approval of the Australian Treasurer for Kazia, together with its associates, to acquire: (i) more than 20% of an Australian company or business with a total issued securities value or total asset value (whichever is higher) totaling over A$275 million; or (ii) any direct or indirect ownership interest in Australian land. However, as mentioned above, in general terms, proposals by U.S. investors for investment in non-sensitive sectors do not require notification to the Australian Treasurer or the Australian Treasurer’s approval unless the value of the target Australian company or business exceeds A$1,192 million.

The percentage of foreign ownership of Kazia would also be included in determining the foreign ownership of any Australian company or business in which it may choose to invest. Kazia has no current plans for any such acquisitions. The Company’s Constitution does not impose specific limitations on a non-resident’s right to hold or vote the Company’s securities.

E. Taxation

U.S. Taxation

This section describes the material U.S. federal income tax consequences to a U.S. holder (as defined below) of owning ordinary shares or ADSs. It applies only to ordinary shares or ADSs that are held as capital assets for tax purposes. This section does not apply to a holder of ordinary shares or ADSs that is a member of a class of holders subject to special rules, including a financial institution, a dealer or trader in securities, a regulated investment company, a real estate investment trust, a grantor trust, a U.S. expatriate, a tax-exempt organization, an insurance company, a person liable for alternative minimum tax, a person who actually or constructively owns 10% or more of the stock of the Company, a person that holds ordinary shares or ADSs as part of a straddle or a hedging or conversion transaction, a person that purchases or sells ordinary shares or ADSs as part of a wash sale for tax purposes, or a person whose functional currency is not the U.S. dollar. Further, this description does not address state, local, non-U.S, or other tax laws, nor does it address the 3.8% U.S. federal Medicare tax on net investment income, the alternative minimum tax or the U.S. federal gift and estate tax consequences of owning and disposing of ordinary shares or ADSs.

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For purposes of this description, a “U.S. holder” is a beneficial owner of ordinary shares or ADSs who holds such ordinary shares or ADSs as capital assets within the meaning of the Code and is, for U.S. federal income tax purposes: (i) an individual citizen or resident of the United States; (ii) a corporation created or organized in or under the laws of the United States or any state thereof, including the District of Columbia; (iii) an estate the income of which is subject to U.S. federal income taxation regardless of its source; or (iv) a trust that either (a) is subject to the supervision of a court within the United States and has one or more U.S. persons with authority to control all substantial decisions or (b) has a valid election in effect under applicable Treasury Regulations to be treated as a U.S. person.

If a partnership holds the ordinary shares or ADSs, the U.S. federal income tax treatment of a partner generally will depend on the status of the partner and the tax treatment of the partnership. A partner in a partnership holding the ordinary shares or ADSs should consult its tax advisor with regard to the U.S. federal income tax treatment of an investment in the ordinary shares or ADSs.

This section is in part based on the representations of the Depositary and the assumption that each obligation in the deposit agreement and any related agreement will be performed in accordance with its terms. In general, for U.S. federal income tax purposes, a holder of ADSs will be treated as the owner of the ordinary shares represented by those ADSs. Exchanges of ordinary shares for ADSs, and ADSs for ordinary shares generally will not be subject to U.S. federal income tax.

Distributions

Subject to the Passive Foreign Investment Company (“PFIC”) rules discussed below, U.S. holders generally will include as dividend income the U.S. dollar value of the gross amount of any distributions of cash or property (without deduction for any withholding tax), other than certain pro rata distributions of ordinary shares, with respect to ordinary shares or ADSs to the extent the distributions are made from our current or accumulated earnings and profits, as determined for U.S. federal income tax purposes. A U.S. holder will include the dividend income on the day actually or constructively received (i) by the holder, in the case of ordinary shares, or (ii) by the depositary, in the case of ADSs. We do not intend to maintain calculations of earnings and profits, as determined for U.S. federal income tax purposes. Consequently, any distributions generally will be treated as dividend income.

Dividends paid to a non-corporate U.S. holder on shares or ADSs will generally be taxable at the preferential rates applicable to long-term capital gains provided (a) that certain holding period requirements are satisfied, (b) (i) the U.S.-Australia income tax treaty (“the Treaty”) is a qualified treaty and we are eligible for benefits under the Treaty or (ii) our ordinary shares or ADSs are readily tradable on a U.S. securities market, and (c) provided that we were not, in the taxable year prior to the year in which the dividend was paid, and are not, in the taxable year in which the dividend is paid, a PFIC. The Treaty has been approved for the purposes of the qualified dividend rules and the ADSs are listed on NASDAQ. If the Company is a PFIC, any dividends paid to a noncorporate U.S. holder will not qualify for the preferential tax rates ordinarily applicable to “qualified dividends.” In the case of a corporate U.S. holder, dividends on shares and ADSs are taxed as ordinary income and will not be eligible for the dividends received deduction generally allowed to U.S. corporations in respect of dividends received from other U.S. corporations.

The amount of any cash distribution paid in any foreign currency will be equal to the U.S. dollar value of such currency, calculated by reference to the spot rate in effect on the date such distribution is received by the U.S. holder or, in the case of ADSs, by the Depositary, regardless of whether and when the foreign currency is in fact converted into U.S. dollars. If the foreign currency is converted into U.S. dollars on the date received, the U.S. holder generally should not recognize foreign currency gain or loss on such conversion. If the foreign currency is not converted into U.S. dollars on the date received, the U.S. holder will have a basis in the foreign currency equal to its U.S. dollar value on the date received, and generally will recognize foreign currency gain or loss on a subsequent conversion or other disposal of such currency. Such foreign currency gain or loss generally will be treated as U.S. source ordinary income or loss for foreign tax credit limitation purposes.

Dividends will be income from sources outside the United States, and generally will be “passive category” income or, for certain taxpayers, “general category” income, which are treated separately from each other for the purpose of computing the foreign tax credit allowable to a U.S. holder. The availability of the foreign tax credit and the application of the limitations on its availability are fact specific and are subject to complex rules. In general, a taxpayer’s ability to use foreign tax credits may be limited and is dependent on the particular circumstances. U.S. holders should consult their own tax advisors with respect to these matters.

Sale, Exchange or other Disposition of Ordinary Shares or ADSs

Subject to the PFIC rules discussed below, a U.S. holder who sells or otherwise disposes of ordinary shares or ADSs will recognize a capital gain or loss for U.S. federal income tax purposes equal to the difference between the U.S. dollar value of the amount realized and the holder’s tax basis, determined in U.S. dollars, in those ordinary shares or ADSs. The gain or loss will generally be income or loss from sources within the United States for foreign tax credit limitation purposes. The capital gain of a non-corporate U.S. holder is generally taxed at preferential rates where the holder has a holding period greater than 12 months in the shares or ADSs sold. There are limitations on the deductibility of capital losses.

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The U.S. dollar value of any foreign currency received upon a sale or other disposition of ordinary shares or ADSs will be calculated by reference to the spot rate in effect on the date of sale or other disposal (or, in the case of a cash basis or electing accrual basis taxpayer, at the spot rate of exchange on the settlement date). A U.S. holder will have a tax basis in the foreign currency received equal to that U.S. dollar amount, and generally will recognize foreign currency gain or loss on a subsequent conversion or other disposal of the foreign currency. This foreign currency gain or loss generally will be treated as U.S. source ordinary income or loss for foreign tax credit limitation purposes. If such foreign currency is converted into U.S. dollars on the date received by the U.S. holder, a cash basis or electing accrual basis U.S. holder should not recognize any gain or loss on such conversion.

Passive Foreign Investment Company

A non-U.S. corporation will be a PFIC for U.S. federal income tax purposes for any taxable year if either:

| • |  | 75% or more of its gross income for such year is “passive income” which for this purpose generally includes dividends, interest, royalties, rents and gains from commodities and securities transactions and gains from assets that produce passive income; or

| • |  | 50% or more of the value of its gross assets (based on an average of the quarterly values of the gross assets) during such year is attributable to assets that produce passive income or are held for the production of passive income.

Passive income does not include rents and royalties derived from the active conduct of a trade or business. If the stock of a non-U.S. corporation is publicly traded for the taxable year, the asset test is applied using the fair market value of the assets for purposes of measuring such corporation’s assets. If we own at least 25% (by value) of the stock of another corporation, we will be treated, for purposes of the PFIC tests, as owning our proportionate share of the other corporation’s assets and receiving our proportionate share of the other corporation’s income for purposes of the PFIC income and asset tests. If the stock of a non-U.S. corporation is publicly-traded for the taxable year, the asset test is applied using the fair market value of the assets for purposes of measuring such corporation’s assets. If we were a PFIC in any year during a U.S. holder’s holding period for our ordinary shares or ADSs, we would ordinarily continue to be treated as a PFIC for each subsequent year during which the U.S. holder owned the ordinary shares or ADSs. Based on the composition of our assets and income, we believe that we may be treated as a PFIC for U.S. federal income tax purposes with respect to our 2020 taxable year. However, the determination of PFIC status is a factual determination that must be made annually at the close of each taxable year and therefore, there can be no certainty as to our status in this regard until the close of the current or any future taxable year. Changes in the nature of our income or assets or a decrease in the trading price of our ordinary shares or ADSs may cause us to be considered a PFIC in the current or any subsequent year.

U.S. Information Reporting and Back-up Withholding

Dividend payments with respect to our ordinary shares or ADSs and proceeds from the sale or other disposition of our ordinary shares or ADSs may be subject to information reporting to the IRS and possible U.S. backup withholding. Back-up withholding will not apply, however, to a U.S. holder who furnishes a correct taxpayer identification number and makes any other required certification or who is otherwise exempt from back-up withholding. U.S. holders who are required to establish their exempt status may be required to provide such certification on Internal Revenue Service (“IRS”) Form W-9. U.S. holders should consult their tax advisors regarding the application of the U.S. information reporting and back-up withholding rules.

Back-up withholding is not an additional tax. Amounts withheld as back-up withholding may be credited against a U.S. holder’s U.S. federal income tax liability, and such holder may obtain a refund of any excess amounts withheld under the back-up withholding rules by timely filing the appropriate claim for refund with the IRS and furnishing any required information.

Information With Respect to Foreign Financial Assets

Certain U.S. holders that own “specified foreign financial assets” with an aggregate value in excess of $50,000 are generally required to file an information statement along with their U.S. federal tax returns, currently on IRS Form 8938, with respect to such assets. “Specified foreign financial assets” include any financial accounts held at a non-U.S. financial institution, as well as securities issued by a non-U.S. issuer that are not held in accounts maintained by financial institutions. If a U.S. holder does not include in such holder’s gross income an amount relating to one or more specified foreign financial assets, and the amount such U.S. holder omits is more than $5,000, any tax such U.S. holder owes for the tax year can be assessed at any time within 6 years after the filing of such U.S. holder’s federal tax return. U.S. holders who fail to report the required information could be subject to substantial penalties. U.S. holders are encouraged to consult with their own tax advisors regarding the possible application of the foregoing to our ordinary shares or ADSs in light of their particular circumstances.

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Australian Tax Considerations

In this section, we discuss the material Australian income tax, stamp duty and goods and services tax considerations related to the acquisition, ownership and disposal by the absolute beneficial owners of the ordinary shares or ADSs.

It is based upon existing Australian tax law as of the date of this registration statement, which is subject to change, possibly retrospectively. This discussion does not address all aspects of Australian tax law which may be important to particular investors in light of their individual investment circumstances, such as shares held by investors subject to special tax rules (for example, financial institutions, insurance companies or tax-exempt organizations). In addition, this summary does not discuss any foreign or state tax considerations, other than stamp duty.

Prospective investors are urged to consult their tax advisors regarding the Australian and foreign income and other tax considerations of the acquisition, ownership and disposition of the shares. This summary is based upon the premise that the holder is not an Australian tax resident and is not carrying on business in Australia through a permanent establishment (referred to as a “Non-Australian Shareholder” in this summary).

Australian Income Tax

Nature of ADSs for Australian Taxation Purposes

Ordinary shares represented by ADSs held by a U.S. holder will be treated for Australian taxation purposes as held under a “bare trust” for such holder. Consequently, the underlying ordinary shares will be regarded as owned by the ADS holder for Australian income tax and capital gains tax purposes. Dividends paid on the underlying ordinary shares will also be treated as dividends paid to the ADS holder, as the person beneficially entitled to those dividends. Therefore, in the following analysis we discuss the tax consequences to Non-Australian Shareholders which, for Australian taxation purposes, will be the same as to U.S. holders of ADSs.

Taxation of Dividends

Australia operates a dividend imputation system under which dividends may be declared to be “franked” to the extent of tax paid on company profits. Fully franked dividends are not subject to dividend withholding tax. Dividends payable to Non-Australian Shareholders will be subject to dividend withholding tax, to the extent the dividends are not declared to be conduit foreign income, or CFI, and are unfranked. Dividend withholding tax will be imposed at 30%, unless a shareholder is a resident of a country with which Australia has a double taxation agreement and qualifies for the benefits of the treaty. Under the provisions of the current Double Taxation Convention between Australia and the United States, the Australian tax withheld on unfranked dividends that are not CFI paid by us to whom a resident of the United States is beneficially entitled is limited to 15%.

If a company that is a Non-Australian Shareholder directly owns a 10% or more interest, the Australian tax withheld on unfranked dividends (that are not CFI) paid by us to whom a resident of the United States is beneficially entitled is limited to 5%. In limited circumstances, the rate of withholding can be reduced to zero.

Tax on Sales or other Dispositions of Shares—Capital Gains Tax

Non-Australian Shareholders will not be subject to Australian capital gains tax on the gain made on a sale or other disposal of ordinary shares, unless they, together with associates, hold 10% or more of our issued capital, at the time of disposal or for 12 months of the last two years prior to disposal.

Non-Australian Shareholders who own a 10% or more interest would be subject to Australian capital gains tax if more than 50% of our assets held directly or indirectly, determined by reference to market value, consists of Australian real property (which includes land and leasehold interests) or Australian mining, quarrying or prospecting rights. The Double Taxation Convention between the United States and Australia is unlikely to limit the amount of this taxable gain. Australian capital gains tax applies to net capital gains of foreign shareholders at the Australian tax rates for non-Australian residents, which start at a marginal rate of 32.5% for individuals (or a flat rate of 27.5% or 30% for companies, depending on the size of the company). Net capital gains are calculated after reduction for capital losses, which may only be offset against capital gains.

The 50% capital gains tax discount is not available to Non-Australian Shareholders. Companies are not entitled to a capital gains tax discount.

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Broadly, where there is a disposal of certain taxable Australian property, the purchaser will be required to withhold and remit to the Australian Taxation Office (“ATO”) 12.5% of the proceeds from the sale. A transaction is excluded from the withholding requirements in certain circumstances, including where the value of the taxable Australian property is less than A$750,000, the transaction is an on-market transaction conducted on an approved stock exchange, a securities lending, or the transaction is conducted using a broker operated crossing system. There is also an exception to the requirement to withhold where the entity selling the shares provides the purchaser a declaration specifying either that they are an Australian resident or that the shares are not taxable Australian property (specifically, not ‘indirect Australian real property interests’). The Non-Australian Shareholder may be entitled to receive a tax credit for the tax withheld by the purchaser which they may claim in their Australian income tax return.

Tax on Sales or other Dispositions of Shares—Shareholders Holding Shares on Revenue Account

Some Non-Australian Shareholders may hold ordinary shares on revenue rather than on capital account for example, share traders. These shareholders may have the gains made on the sale or other disposal of the ordinary shares and/or warrants included in their assessable income under the ordinary income provisions of the income tax law, if the gains are sourced in Australia.

Non-Australian Shareholders assessable under these ordinary income provisions in respect of gains made on ordinary shares held on revenue account would be assessed for such gains at the Australian tax rates for non-Australian residents, which start at a marginal rate of 32.5% for individuals (or a flat rate of 27.5% or 30% for companies, depending on the size of the company). Some relief from Australian income tax may be available to Non-Australian Shareholders under the Double Taxation Convention between the United States and Australia.

To the extent an amount would be included in a Non-Australian Shareholder’s assessable income under both the capital gains tax provisions and the ordinary income provisions, the capital gain amount would generally be reduced, so that the shareholder would not be subject to double tax on any part of the income gain or capital gain.

The comments above in “Tax on Sales or Other Dispositions of Shares—Capital Gains Tax” regarding a purchaser being required to withhold 12.5% tax on the acquisition of certain taxable Australian property equally applies where the disposal of the Australian real property asset by a foreign resident is likely to generate gains on revenue account, rather than a capital gain.

Dual Residency

If a shareholder is a resident of both Australia and the United States under those countries’ domestic taxation laws, that shareholder may be subject to tax as an Australian resident. If, however, the shareholder is determined to be a U.S. resident for the purposes of the Double Taxation Convention between the United States and Australia, the Australian tax would be subject to limitation by the Double Taxation Convention (albeit the tie-breaker rules only apply for individuals). Shareholders should obtain specialist taxation advice in these circumstances.

Stamp Duty

No Australian stamp duty is payable by Australian residents or non-Australian residents on the issue, transfer and/or surrender of the ADSs or the ordinary shares in Kazia, provided that the shares issued, transferred and/or surrendered do not represent 90% or more of the issued shares in Kazia.

Australian Death Duty

Australia does not have estate or death duties. As a general rule, no capital gains tax liability is realized upon the inheritance of a deceased person’s shares. The disposal of inherited shares by beneficiaries may, however, give rise to a capital gains tax liability if the gain falls within the scope of Australia’s jurisdiction to tax.

Goods and Services Tax

The supply of ADSs or ordinary shares in Kazia will not be subject to Australian goods and services tax.

F. Dividends and paying agents

Not applicable

G. Statement by experts

Not applicable

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H. Documents on Display

The Company is subject to the reporting requirements of the Exchange Act that are applicable to a foreign private issuer. Under the Exchange Act, the Company is required to file periodic reports and other information with the SEC. These materials, including this Annual Report and the exhibits hereto, may be inspected without charge and copied at established rates at the public reference facilities maintained by the SEC at 100 F Street, N.E., Washington, D.C., 20549. Please call the SEC at 1-800-SEC-0330 to obtain information on the operation of the public reference room. Such materials can also be obtained at the SEC’s website at www.sec.gov.

I. Subsidiary Information

Not applicable

Item 11. | Quantitative and Qualitative Disclosures about Market Risk

Interest rate risk

The Company’s exposure to market interest rates relate primarily to the investments of cash balances. The Company has cash reserves held primarily in Australian dollars and places funds on deposit with financial institutions for periods generally not exceeding three months.

Credit risk

The Company places its deposits with high credit quality financial institutions, and, by policy, limits the amount of credit exposure to any single counter-party. The Company is averse to principal loss and ensures the safety and preservation of its invested funds by limiting default risk, market risk and reinvestment risk. The Company mitigates default risk by depositing funds with only the safest and highest credit quality financial institutions and by constantly positioning its portfolio to respond appropriately to a significant reduction in a credit rating of any financial institution.

The Company has no interest rate exposure due to rate changes for long-term debt obligations. The Company primarily enters into debt obligations to support general corporate purposes, including capital expenditures and working capital needs. The Company does not consider the effects of interest rate movements to be a material risk to its financial condition.

For additional disclosure regarding interest rate risk see Item 18. “Financial Statements – Note 22 – Financial Instruments”.

Foreign currency risk

The Company operates internationally and is exposed to foreign exchange risk arising from various currency exposures, primarily with respect to the U.S. dollar. Foreign exchange risk arises from future transactions and recognised assets and liabilities denominated in a currency that is not the entity’s functional currency and net investments in foreign operations.

As of June 30, 2020, the Company did not hold derivative financial instruments in managing its foreign currency, however, the Company may from time to time enter into hedging arrangements where circumstances are deemed appropriate. The Company used natural hedging to reduce the foreign currency risk, which involved processing USD payments from cash held in USD. Foreign subsidiaries with a functional currency of Australian Dollar (“AUD”) have exposure to the local currency of these subsidiaries and any other currency these subsidiaries trade in.

For additional disclosure regarding market risk see Item 18. “Financial Statements – Note 22 – Financial Instruments”.

Item 12. | Description of Securities Other than Equity Securities

A. Debt Securities

Not applicable

B. Warrants and Rights

Not applicable.

C. Other Securities

Not applicable

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D. American Depositary Shares

The depositary collects its fees for delivery and surrender of American Depositary Shares (“ADSs”) directly from investors depositing shares or surrendering ADSs for the purpose of withdrawal or from intermediaries acting for them. The depositary collects fees for making distributions to investors by deducting those fees from the amounts distributed or by selling a portion of distributable property to pay the fees. The depositary may collect its annual fee for depositary services by deductions from cash distributions or by directly billing investors or by charging the book-entry system accounts of participants acting for them. The depositary may generally refuse to provide fee-attracting services until its fees for those services are paid. The depositary may collect any of its fees by deduction from any cash distribution payable to you that are obligated to pay those fees.

From time to time, the depositary may make payments to us to reimburse or share revenue from the fees collected from you, or waive fees and expenses for services provided, generally relating to costs and expenses arising out of establishment and maintenance of the ADS program. In performing its duties under the deposit agreement, the depositary may use brokers, dealers or other service providers that are affiliates of the depositary and that may earn or share fees or commissions.

Persons depositing or withdrawing shares must pay: |  |  |  | For:
US$5.00 (or less) per 100 ADSs (or portion of 100 ADSs) |  | • |  | Issuance of ADSs, including issuances resulting from a distribution of shares or rights or other property
|  | • |  | Cancellation of ADSs for the purpose of withdrawal, including if the deposit agreement terminates
US$.05 (or less) per ADS |  | • |  | Any cash distribution to ADS registered holders
A fee equivalent to the fee that would be payable if securities distributed to you had been shares and the shares had been deposited for issuance of ADSs |  | • |  | Distribution of securities distributed to holders of deposited securities which are distributed by the depositary to ADS registered holders
US$.05 (or less) per ADSs per calendar year |  | • |  | Depositary services
Registration or transfer fees |  | • |  | Transfer and registration of shares on the Company’s share register to or from the name of the depositary or its agent when you deposit or withdraw shares
Expenses of the depositary |  | • |  | Cable, telex and facsimile transmissions (when expressly provided in the deposit agreement)
|  | • |  | Converting foreign currency to U.S. dollars
Taxes and other governmental charges the depositary or the custodian have to pay on any ADS or share underlying an ADS, for example, stock transfer taxes, stamp duty or withholding taxes |  | • |  | As necessary
Any charges incurred by the depositary or its agents for servicing the deposited securities |  | • |  | As necessary

The Depositary may collect any of the fees by deduction from any cash distribution payable, or by selling a portion of any securities to be distributed, to holders that are obligated to pay those fees.

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##### Table of Contents

PART II

Item 13. | Defaults, Dividend Arrearages and Delinquencies

This item is not applicable.

Item 14. | Material Modifications to the Rights of Security Holders and the Use of Proceeds

This item is not applicable.

Item 15. | Controls and Procedures

(a) Disclosure controls and procedures

At the end of the period covered by this Annual Report, the Company’s management, with the participation of the Chief Executive Officer and the Director of Finance and Administration, evaluated the effectiveness of the Company’s disclosure controls and procedures (as defined in Rules 13a-15(e) and 15d-15(e) under the Exchange Act). Based on that evaluation, the Company’s Chief Executive Officer and the Director of Finance and Administration have concluded that the Company’s disclosure controls and procedures are effective as of June 30, 2020.

(b) Management’s annual report on internal controls over financial reporting

The management of Kazia Therapeutics Limited is responsible for establishing and maintaining adequate internal control over financial reporting as defined in Rules 13a-15(f) under the Exchange Act. Under the supervision and with the participation of our management, including our Chief Executive Officer and Director of Finance and Administration, we conducted an evaluation of the effectiveness of our internal control over financial reporting as of June 30, 2020 based on the criteria set forth in Internal Control—Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission (COSO 2013). Based on our evaluation under the criteria set forth in Internal Control — Integrated Framework, our management concluded that our internal control over financial reporting was effective as of June 30, 2020.

Kazia Therapeutics Limited’s internal control was designed to provide reasonable assurance to the Company’s management and Board of Directors regarding the preparation and fair presentation of published financial statements. All internal control systems, no matter how well designed, have inherent limitations. Therefore, even those systems determined to be effective can provide only reasonable assurance with respect to financial statement preparation and presentation.

Management maintains a comprehensive system of controls intended to ensure that transactions are executed in accordance with management’s authorization, assets are safeguarded, and financial records are reliable. Management also takes steps to ensure that information and communication flows are effective and monitor performance, including performance of internal control procedures.

Management assessed the effectiveness of the Company’s internal control over financial reporting as of June 30, 2020. Based on this assessment, management concluded that the Company’s internal control over financial reporting is effective as of June 30, 2020.

(c) Attestation Report of the Registered Public Accounting Firm

Not applicable.

(d) Changes in Internal Control over Financial Reporting

There was no change in our internal control over financial reporting that occurred during the period covered by this annual report that has materially affected, or is reasonably likely to materially affect, our internal control over financial reporting.

Item 16. | [Reserved]

Item 16A. | Audit Committee Financial Expert

The Board of Directors has determined that Steven Coffey, qualifies as an “audit committee financial expert” as that term is defined in Item 16A of Form 20-F. Steven Coffey meets the independence requirements of the NASDAQ Capital Market and SEC’s rules and regulations as he is a qualified Chartered Accountant and has spent over 30 years in public practice. He is also a registered company auditor.

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##### Table of Contents

Item 16B. | Code of Ethics

The Company has adopted a Code of Ethics and Business Conduct (the “Code”). The Code establishes a clear set of values that emphasise a culture encompassing strong corporate governance, sound business practices and good ethical conduct. The Code confirms the Company’s belief in treating all individuals with respect and recognises that different skills and diversity are essential to enrich the Company’s perspective, improve corporate performance, increase shareholder value and maximise the achievement and goals of the Company. The Code applies to all Company employees, including management and Directors. The Code is available on the Company’s website www.kaziatherapeutics.com.

Item 16C. | Principal Accounting Fees and Services

Grant Thornton Audit Pty Ltd (“GT”) has audited the Company’s annual financial statements acting as the independent registered public accounting firm for the fiscal years ended June 30, 2020, 2019 and 2018.

The table below set forth the total fees for services performed by GT in fiscal years 2020, 2019 and 2018, and summarizes these amounts by the category of service.

|  | 2020 A$’000 |  |  | 2019 A$’000 |  |  | 2018 A$’000 |
Audit fees - Grant Thornton Audit Pty Ltd |  |  | 124 |  |  |  | 120 |  |  |  | 131 |
SEC Form F3 consent |  |  | — |  |  |  | — |  |  |  | 11 |
Total fees |  |  | 124 |  |  |  | 120 |  |  |  | 142 |

Audit fees

The audit fees include the aggregate fees incurred in fiscal years 2020 and 2019 for professional services rendered in connection with the audit of the Company’s annual financial statements and for related services that are reasonably related to the performance of the audit or services that are normally provided by the auditor in connection with regulatory filings of engagements for those financial years (including review of the Company’s Annual Report on Form 20-F, consents and other services related to SEC matters).

SEC Form F3 consent

Fees paid in respect of filing of SEC Form F-3 consent services, which relates to procedures required by the auditor to issue their consent in the document.

Pre-approval policies and procedures

The Audit Committee Charter sets forth the Company’s policy regarding the appointment of independent auditors. The Audit Committee Charter also requires the Audit Committee to review and approve in advance the appointment of the independent auditors for the performance of 100% of all audit services and, after taking into account the opinion of management, 100% of lawfully permitted non-audit services. The Audit Committee may delegate authority to one or more members of the Audit Committee where appropriate, but no such delegation is permitted if the authority is required by law, regulation or listing standard to be exercised by the Audit Committee as a whole.

In fiscal year 2020, the amount paid to Grant Thornton for services other than Audit fees amounted to nil.

Item 16D. | Exemptions from the Listing Standards for Audit Committees

This item is not applicable.

Item 16E. | Purchases of Equity Securities by the Issuer and Affiliated Purchasers

This item is not applicable.

Item 16F. | Changes in registrant’s Certifying Accountant

This item is not applicable.

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Item 16G. | Corporate Governance

Implications of Being a Foreign Private Issuer

We are also considered a “foreign private issuer.” In our capacity as a foreign private issuer, we are exempt from certain rules under the U.S. Securities Exchange Act of 1934, as amended (the “Exchange Act”), that impose certain disclosure obligations and procedural requirements for proxy solicitations under Section 14 of the Exchange Act. In addition, our officers, directors and principal shareholders are exempt from the reporting and “short-swing” profit recovery provisions of Section 16 of the Exchange Act and the rules under the Exchange Act with respect to their purchases and sales of our ordinary shares. Moreover, we are not required to file periodic reports and financial statements with the SEC as frequently or as promptly as U.S. companies whose securities are registered under the Exchange Act. In addition, we are not required to comply with Regulation FD, which restricts the selective disclosure of material information.

Exemptions from Certain Corporate Governance Rules of the NASDAQ Stock Market, LLC

Exemptions from the corporate governance standards of the NASDAQ Stock Market, LLC (“NASDAQ”) are available to foreign private issuers such as Kazia when those standards are contrary to a law, rule or regulation of any public authority exercising jurisdiction over such issuer or contrary to generally accepted business practices in the issuer’s country of domicile. In connection with Kazia’s National Market Listing Application, NASDAQ granted Kazia exemptions from certain corporate governance standards that were contrary to the laws, rules, regulations or generally accepted business practices of Australia. These exemptions and the practices followed by Kazia are described below:

| • |  | Kazia is exempt from NASDAQ’s quorum requirements applicable to meetings of ordinary shareholders. In keeping with the law of Australia and generally accepted business practices in Australia, Kazia’s Constitution requires a quorum of three shareholders for a shareholders’ meeting.

| • |  | Kazia is exempt from NASDAQ’s requirement that each NASDAQ issuer shall require shareholder approval of a plan or arrangement in connection with the acquisition of the stock or assets of another company if “any director, officer or substantial shareholder of the issuer has a 5 percent or greater interest (or such persons collectively have a 10 percent or greater interest), directly or indirectly, in the Company or assets to be acquired or in the consideration to be paid in the transaction or series of related transactions and the present or potential issuance of common stock, or securities convertible into or exercisable for common stock, could result in an increase in outstanding common shares or voting power of 5 percent or more”.

| • |  | Kazia will rely on an exemption from the requirement that at least two members of a compensation committee be “independent” as defined in NASDAQ Rule 5605(a) (2). The ASX Listing Rules and Australian law do not require an Australian company to establish a compensation committee, known in Australia as a remuneration committee, which is comprised solely of non-executive directors if the company is not included in the S&P/ASX300 Index at the beginning of its financial year. Kazia was not included on the S&P/ASX300 Index at the beginning of its last financial year and, hence, is not required under ASX Listing Rules to have a remuneration (compensation) committee. The ASX Corporate Governance Principles and Recommendations contain a non-binding recommendation that all ASX-listed companies should have a remuneration committee comprised of at least three members, a majority of whom (including the chair) are “independent”. While these recommendations contain guidelines for assessing independence, ASX-listed entities are able to adopt their own definitions of an independent director for this purpose and is different from the definition in NASDAQ Rule 5605(a) (2). That being said, Kazia has, and expects to continue to have, a Remuneration and Nomination Committee consisting of three non-executive directors.

Kazia is listed on the ASX and subject to Chapter 10 of the ASX listing rules which requires shareholder approval for an acquisition from or disposal to a “related party” (including a director) or “substantial shareholder” (who is entitled to at least 10% of the voting securities) of “substantial assets”. The Australian Corporations Act to which Kazia is also subject generally requires shareholder approval for a transaction with a director or director-controlled entity unless on arm’s length terms.

Item 16H. | Mine Safety Disclosure

This item is not applicable.

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PART III

Item 17. | Financial Statements

Refer to “Item 18 – Financial Statements” below

Item 18. | Financial Statements

The financial statements filed as part of this Annual Report commencing on page F-1.

Item 19. | Exhibits

(a) | Exhibits

1.1 |  | Constitution of Kazia Therapeutics Limited, as amended and restated on November 16, 2016 (incorporated by reference to Exhibit 1.1 to the Company’s Annual Report on Form 20-F filed with the SEC on October 25, 2017 (File No. 0-29962)).
2.1 |  | Deposit Agreement, dated as of June 6, 2016 among Novogen Limited, The Bank of New York, as Depositary, and owners and holders from time to time of ADSs issued thereunder (incorporated by reference to Exhibit 2.1 to the Company’s Annual Report on Form 20-F filed with the SEC on October 27, 2016 (File No. 0-29962)).
4.1 |  | Lease Agreement, dated November 1, 2015 between Coal Services Pty Limited and Novogen (incorporated by reference to Exhibit 4.1 to the Company’s Annual Report on Form 20-F filed with the SEC on October 27, 2016 (File No. 0-29962)).
4.2 |  | Employment Agreement for Chief Executive Officer of Novogen Limited, dated December 10, 2015 (incorporated by reference to Exhibit 4.2 to the Company’s Annual Report on Form 20-F filed with the SEC on October 27, 2016 (File No. 0-29962)).
4.3 |  | Employment Agreement for Director of Finance and Administration of Novogen Limited, dated as of July 3, 2017 (incorporated by reference to Exhibit 4.20 to the Company’s Annual Report on Form 20-F filed with the SEC on October 25, 2017 (File No. 0-29962)).
4.4 |  | Convertible Note Deed Poll with Triaxial Pty Ltd Noteholders dated December 6, 2012 (incorporated by reference to Exhibit 4.6 to the Company’s Annual Report on Form 20-F filed with the SEC on October 27, 2016 (File No. 0-29962)).
4.5 |  | Amendment to Convertible Note Deed Poll with Triaxial Pty Ltd Noteholders dated December 4, 2014 (incorporated by reference to Exhibit 4.7 to the Company’s Annual Report on Form 20-F filed with the SEC on October 27, 2016 (File No. 0-29962)).
4.6 |  | Kazia Therapeutics Officers’ and Employees’ Share Option Plan (incorporated by reference to Exhibit 4.10 to the Company’s Annual Report on Form 20-F filed with the SEC on October 27, 2016 (File No.0-29962)).
4.7 |  | Share Sale Agreement dated October 31, 2016 between Kilinwata Investments Pty. Ltd., Mi Ok Chong, Paul Hopper and Novogen Limited (Incorporated by reference to Exhibit 4.11 to the Company’s Annual Report on Form 20-F filed with the SEC on October 25, 2017 (File No. 0-29962)).

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4.8 |  | Exclusive License Agreement dated October 25, 2016 between Genentech, Inc. and Novogen Limited (incorporated by reference to Exhibit 4.12 to the Company’s Annual Report on Form 20-F filed with the SEC on October 25, 2017 (File No. 0-29962)).
4.9 |  | Sabio Solutions Pty Limited Letter of Appointment – Company Secretary, dated as of September 1, 2016 (incorporated by reference to Exhibit 4.17 to the Company’s Annual Report on Form 20-F filed with the SEC on October 25, 2017 (File No. 0-29962)).
4.10 |  | Sabio Solutions Pty Limited Contract Extension Letter, dated as of March 1, 2017 (incorporated by reference to Exhibit 4.18 to the Company’s Annual Report on Form 20-F filed with the SEC on October 25, 2017 (File No. 0-29962)).
4.11 |  | Sabio Solutions Pty Limited Contract Extension Letter, dated as of August 23, 2017 (incorporated by reference to Exhibit 4.19 to the Company’s Annual Report on Form 20-F filed with the SEC on October 25, 2017 (File No. 0-29962)).
4.12 |  | Investigator Initiated Clinical Trial Agreement between Kazia Therapeutics Limited and Dana-Farber/Partners Cancer Care Inc dated 17 October 2018 (incorporated by reference to Exhibit 4.12 to the Company’s Annual Report on Form 20-F filed with the SEC on October 21, 2019)
4.13 |  | Research Funding and Supply Agreement between Alliance for Clinical Trials in Oncology Foundation and Kazia Therapeutics Limited, dated 11 June 2019 (incorporated by reference to Exhibit 4.13 to the Company’s Annual Report on Form 20-F filed with the SEC on October 21, 2019)
4.14 |  | Master Clinical Trial Agreement between St Jude Children’s Hospital Inc. and Kazia Laboratories Pty Limited dated 17 November 2017 and associated work order date 7 June 2019 (incorporated by reference to Exhibit 4.14 to the Company’s Annual Report on Form 20-F filed with the SEC on October 21, 2019)
4.15 |  | Memorial Sloan Kettering Cancer Center Investigator-Initiated Clinical Trial Agreement with Kazia Therapeutics Limited dated as 22 July 2019 (incorporated by reference to Exhibit 4.15 to the Company’s Annual Report on Form 20-F filed with the SEC on October 22, 2020)
4.16 |  | Investigator Initiated Clinical Trial Agreement with Kazia Therapeutics Limited Agreement dated as 18 September 2020 (incorporated by reference to Exhibit 4.16 to the Company’s Annual Report on Form 20-F filed with the SEC on October 22, 2020)
4.17 |  | Global Coalition for Adaptive Research, (“GCAR”) Clinical trial collaboration and supply agreement dated as 15 October 2020 (incorporated by reference to Exhibit 4.16 to the Company’s Annual Report on Form 20-F filed with the SEC on October 22, 2020)
8.1 |  | Company Subsidiaries (incorporated by reference to Exhibit 8.1 to the Company’s Annual Report on Form 20-F filed with the SEC on October 24, 2018 (File No. 0-29962)).
12.1 |  | Certification of Chief Executive Officer pursuant to Rule 13a-14(a) of the Securities Exchange Act of 1934, as amended.
12.2 |  | Certification of Director of Finance and Administration pursuant to Rule 13a-14(a) of the Securities Exchange Act of 1934, as amended.
13.1 |  | Certification of Chief Executive Officer and the Director of Finance and Administration pursuant to 18 U.S.C. Section 1350 as adopted pursuant to section 906 of the Sarbanes-Oxley Act of 2002.
15.1 |  | Consent of Independent Registered Public Accounting Firm.
101.INS |  | XBRL Instance Document
101.SCH |  | XBRL Taxonomy Extension Schema Document
101.CAL |  | XBRL Taxonomy Extension Calculation Linkbase Document
101.DEF |  | XBRL Taxonomy Extension Definition Linkbase Document
101.LAB |  | XBRL Taxonomy Extension Label Linkbase Document
101.PRE |  | XBRL Taxonomy Extension Presentation Linkbase Document

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SIGNATURES

The registrant hereby certifies that it meets all the requirements for filing on Form 20-F and that it has duly caused and authorized the undersigned to sign this Annual Report on its behalf.

KAZIA THERAPEUTICS LIMITED
/s/ James Garner
Dr James Garner
Chief Executive Officer
Date: October 22, 2020

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##### Table of Contents

Index to Financial Statements

|  | Page |
Consolidated Financial Statements for June 30, 2020, 2019, and 2018 and the years then ended: |  |  |  |
Report of Independent Registered Public Accounting Firm |  |  | F-2 |
Consolidated Statement of Profit or Loss and Other Comprehensive Income |  |  | F-3 |
Consolidated Statement of Financial Position |  |  | F-5 |
Consolidated Statement of Changes in Equity |  |  | F-6 |
Consolidated Statement of Cash Flows |  |  | F-8 |
Notes to Consolidated Financial Statements |  |  | F-9 |

F-1

##### Table of Contents

REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

Board of Directors and Shareholders

Kazia Therapeutics Limited

Opinion on the financial statements

We have audited the accompanying consolidated statements of financial position of Kazia Therapeutics Limited and subsidiaries (the “Company”) as of June 30, 2020 and 2019, the related consolidated statements of profit or loss and other comprehensive income, changes in equity, and cash flows for each of the three years in the period ended June 30, 2020 and the related notes (collectively referred to as the “financial statements”). In our opinion, the financial statements present fairly, in all material respects, the financial position of the Company as of June 30, 2020 and 2019, and the results of its operations and its cash flows for each of the three years in the period ended June 30, 2020, in conformity with International Financial Reporting Standards, as issued by the International Accounting Standards Board.

Basis for opinion

These financial statements are the responsibility of the Company’s management. Our responsibility is to express an opinion on the Company’s financial statements based on our audits. We are a public accounting firm registered with the Public Company Accounting Oversight Board (United States) (“PCAOB”) and are required to be independent with respect to the Company in accordance with the U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.

We conducted our audits in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement, whether due to error or fraud. The Company is not required to have, nor were we engaged to perform, an audit of its internal control over financial reporting. As part of our audits we are required to obtain an understanding of internal control over financial reporting but not for the purpose of expressing an opinion on the effectiveness of the Company’s internal control over financial reporting. Accordingly, we express no such opinion.

Our audits included performing procedures to assess the risks of material misstatement of the financial statements, whether due to error or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. Our audits also included evaluating the accounting principles used and significant estimates made by management, as well as evaluating the overall presentation of the financial statements. We believe that our audits provide a reasonable basis for our opinion.

/s/ GRANT THORNTON AUDIT PTY LTD

We have served as the Company’s auditor since 2012.

Sydney, Australia

October 22, 2020

F-2

##### Table of Contents

Consolidated statements of profit or loss and other comprehensive income

For the year ended 30 June 2020

|  | Note |  |  | 2020 A$’000 |  |  | 2019 A$’000 |  |  | 2018 A$’000 |
Revenue from continuing operations |  |  |  |  |  |  | — |  |  |  | — |  |  |  | 119 |
Other income |  |  | 5 |  |  |  | 995 |  |  |  | 1,465 |  |  |  | 12,989 |
Finance income — bank interest |  |  |  |  |  |  | 66 |  |  |  | 100 |  |  |  | — |
Expenses |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and development expense |  |  |  |  |  |  | (9,494 | ) |  |  | (6,475 | ) |  |  | (9,774 | )
General and administrative expense |  |  |  |  |  |  | (3,690 | ) |  |  | (3,785 | ) |  |  | (5,598 | )
Loss on disposal of fixed assets |  |  |  |  |  |  | — |  |  |  | (1 | ) |  |  | (137 | )
Fair value losses on financial assets at fair value through profit or loss |  |  |  |  |  |  | (168 | ) |  |  | (1,809 | ) |  |  | (1,114 | )
Loss on revaluation of contingent consideration |  |  |  |  |  |  | (474 | ) |  |  | (63 | ) |  |  | — |
Impairment of financial assets |  |  |  |  |  |  | — |  |  |  | — |  |  |  | (2,830 | )
Loss before income tax expense from continuing operations |  |  |  |  |  |  | (12,765 | ) |  |  | (10,568 | ) |  |  | (6,344 | )
Income tax benefit |  |  | 7 |  |  |  | 298 |  |  |  | 298 |  |  |  | 305 |
Loss after income tax expense for the year |  |  |  |  |  |  | (12,467 | ) |  |  | (10,270 | ) |  |  | (6,039 | )
Other comprehensive income |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Items that may be reclassified subsequently to profit or loss |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Gain/(Loss) on the revaluation of available-for-sale financial assets, net of tax |  |  |  |  |  |  | — |  |  |  | — |  |  |  | — |
Net exchange difference on translation of financial statements of foreign controlled entities, net of tax |  |  |  |  |  |  | (4 | ) |  |  | (89 | ) |  |  | (251 | )
Other comprehensive income for the year, net of tax |  |  |  |  |  |  | (4 | ) |  |  | (89 | ) |  |  | (251 | )
Total comprehensive income for the year |  |  |  |  |  |  | (12,471 | ) |  |  | (10,359 | ) |  |  | (6,290 | )
Loss for the year is attributable to: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Owners of Kazia Therapeutics Limited |  |  |  |  |  |  | (12,467 | ) |  |  | (10,270 | ) |  |  | (6,039 | )
Total loss for the year |  |  |  |  |  |  | (12,467 | ) |  |  | (10,270 | ) |  |  | (6,039 | )
Total comprehensive income for the year is attributable to: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Owners of Kazia Therapeutics Limited |  |  |  |  |  |  | (12,471 | ) |  |  | (10,359 | ) |  |  | (6,290 | )
Total comprehensive income for the year |  |  |  |  |  |  | (12,471 | ) |  |  | (10,359 | ) |  |  | (6,290 | )

The above consolidated statements of profit or loss or other comprehensive income should be read with the accompanying notes

F-3

##### Table of Contents

Consolidated statements of profit or loss and other comprehensive income (continued)

For the year ended 30 June 2020

|  | Note |  |  | 2020 |  |  | 2019 |  |  | 2018 |
|  |  |  |  | A$ |  |  | A$ |  |  | A$ |
|  |  |  |  | Cents |  |  | Cents |  |  | Cents |
Earnings per share for loss from continuing operations attributable to the owners of Kazia Therapeutics Limited |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basic earnings per share |  |  | 32 |  |  |  | (17.07 | ) |  |  | (17.86 | ) |  |  | (12.48 | )
Diluted earnings per share |  |  | 32 |  |  |  | (17.07 | ) |  |  | (17.86 | ) |  |  | (12.48 | )
|  |  |  |  | 2020 |  |  | 2019 |  |  | 2018 |
|  |  |  |  | A$ |  |  | A$ |  |  | A$ |
|  |  |  |  | Cents |  |  | Cents |  |  | Cents |
Earnings per share for loss attributable to the owners of Kazia Therapeutics Limited |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basic earnings per share |  |  | 32 |  |  |  | (17.07 | ) |  |  | (17.86 | ) |  |  | (12.48 | )
Diluted earnings per share |  |  | 32 |  |  |  | (17.07 | ) |  |  | (17.86 | ) |  |  | (12.48 | )

F-4

##### Table of Contents

Consolidated statements of financial position

As at 30 June 20120

|  | Note |  |  | 2020 A$’000 |  |  | 2019 A$’000 |
Assets |  |  |  |  |  |  |  |  |  |  |  |
Current assets |  |  |  |  |  |  |  |  |  |  |  |
Cash and cash equivalents |  |  | 8 |  |  |  | 8,764 |  |  |  | 5,434 |
Trade and other receivables |  |  | 9 |  |  |  | 1,352 |  |  |  | 1,711 |
Other |  |  | 10 |  |  |  | 537 |  |  |  | 370 |
Total current assets |  |  |  |  |  |  | 10,653 |  |  |  | 7,515 |
Non-current assets |  |  |  |  |  |  |  |  |  |  |  |
Financial assets |  |  | 11 |  |  |  | — |  |  |  | 168 |
Intangibles |  |  | 12 |  |  |  | 12,410 |  |  |  | 13,494 |
Total non-current assets |  |  |  |  |  |  | 12,410 |  |  |  | 13,662 |
Total assets |  |  |  |  |  |  | 23,063 |  |  |  | 21,177 |
Liabilities |  |  |  |  |  |  |  |  |  |  |  |
Current liabilities |  |  |  |  |  |  |  |  |  |  |  |
Trade and other payables |  |  | 13 |  |  |  | 3,489 |  |  |  | 1,764 |
Provisions |  |  | 14 |  |  |  | 191 |  |  |  | 136 |
Contingent consideration |  |  | 15 |  |  |  | 1,387 |  |  |  | — |
Total current liabilities |  |  |  |  |  |  | 5,067 |  |  |  | 1,900 |
Non-Current liabilities |  |  |  |  |  |  |  |  |  |  |  |
Deferred tax |  |  | 16 |  |  |  | 3,413 |  |  |  | 3,711 |
Contingent consideration |  |  | 17 |  |  |  | 458 |  |  |  | 1,371 |
Total non-current liabilities |  |  |  |  |  |  | 3,871 |  |  |  | 5,082 |
Total liabilities |  |  |  |  |  |  | 8,938 |  |  |  | 6,982 |
Net assets |  |  |  |  |  |  | 14,125 |  |  |  | 14,195 |
Equity |  |  |  |  |  |  |  |  |  |  |  |
Contributed equity |  |  | 18 |  |  |  | 48,781 |  |  |  | 36,642 |
Other contributed equity |  |  | 19 |  |  |  | 464 |  |  |  | 464 |
Reserves |  |  | 20 |  |  |  | 1,066 |  |  |  | 2,037 |
Accumulated losses |  |  |  |  |  |  | (36,186 | ) |  |  | (24,948 | )
Equity attributable to the owners of Kazia Therapeutics Limited |  |  |  |  |  |  | 14,125 |  |  |  | 14,195 |
Total equity |  |  |  |  |  |  | 14,125 |  |  |  | 14,195 |

The above consolidated statements of financial position should be read with the accompanying notes

F-5

##### Table of Contents

Statements of changes in equity

For the year ended 30 June 2020

|  | Contributed equity A$’000 |  |  | Other Contributed equity A$’000 |  |  | Reserves A$’000 |  |  | Accumulated Losses A$’000 |  |  | Non- controlling Interest A$’000 |  |  | Total equity A$’000 |
Balance at 1 July 2017 |  |  | 193,769 |  |  |  | 600 |  |  |  | 1,930 |  |  |  | (170,961 | ) |  |  | — |  |  |  | 25,338 |
Loss after income tax expense for the year |  |  | — |  |  |  | — |  |  |  | — |  |  |  | (6,039 | ) |  |  | — |  |  |  | (6,039 | )
Other comprehensive income for the year, net of tax |  |  | — |  |  |  | — |  |  |  | (251 | ) |  |  | — |  |  |  | — |  |  |  | (251 | )
Total comprehensive income for the year |  |  | — |  |  |  | — |  |  |  | (251 | ) |  |  | (6,039 | ) |  |  | — |  |  |  | (6,290 | )
Transactions with owners in their capacity as owners: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share issue costs |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
Transfers |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
Cancellation of share capital |  |  | (162,223 | ) |  |  | — |  |  |  | — |  |  |  | 162,223 |  |  |  | — |  |  |  | — |
Conversion of convertible note |  |  | — |  |  |  | (136 | ) |  |  | — |  |  |  | 136 |  |  |  | — |  |  |  | — |
Employee share-based payment options |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
Share based payment |  |  | — |  |  |  | — |  |  |  | 165 |  |  |  | — |  |  |  | — |  |  |  | 165 |
Issue of shares |  |  | 30 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 30 |
Balance at 30 June 2018 |  |  | 31,576 |  |  |  | 464 |  |  |  | 1,843 |  |  |  | (14,641 | ) |  |  | — |  |  |  | 19,242 |

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##### Table of Contents

Statements of changes in equity (continued)

For the year ended 30 June 2020

|  | Contributed equity A$’000 |  |  | Other Contributed equity A$’000 |  |  | Reserves A$’000 |  |  | Accumulated Losses A$’000 |  |  | Non- controlling Interest A$’000 |  |  | Total equity A$’000 |
Balance at 1 July 2018 |  |  | 31,576 |  |  |  | 464 |  |  |  | 1,843 |  |  |  | (14,641 | ) |  |  | — |  |  |  | 19,242 |
Adjustment for change in accounting policy |  |  | — |  |  |  | — |  |  |  | 37 |  |  |  | (37 | ) |  |  | — |  |  |  | — |
Balance at 1 July 2018 - restated |  |  | 31,576 |  |  |  | 464 |  |  |  | 1,880 |  |  |  | (14,678 | ) |  |  | — |  |  |  | 19,242 |
Loss after income tax expense for the year |  |  | — |  |  |  | — |  |  |  | — |  |  |  | (10,270 | ) |  |  | — |  |  |  | (10,270 | )
Other comprehensive income for the year, net of tax |  |  | — |  |  |  | — |  |  |  | (89 | ) |  |  | — |  |  |  | — |  |  |  | (89 | )
Total comprehensive income for the year |  |  | — |  |  |  | — |  |  |  | (89 | ) |  |  | (10,270 | ) |  |  | — |  |  |  | (10,359 | )
Transactions with owners in their capacity as owners: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share issue costs |  |  | (340 | ) |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | (340 | )
Transfers |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
Share based payment |  |  | — |  |  |  | — |  |  |  | 246 |  |  |  | — |  |  |  | — |  |  |  | 246 |
Issue of shares |  |  | 5,406 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 5,406 |
Balance at 30 June 2019 |  |  | 36,642 |  |  |  | 464 |  |  |  | 2,037 |  |  |  | (24,948 | ) |  |  | — |  |  |  | 14,195 |
|  | Contributed equity A$’000 |  |  | Other Contributed equity A$’000 |  |  | Reserves A$’000 |  |  | Accumulated Losses A$’000 |  |  | Non- controlling Interest A$’000 |  |  | Total equity A$’000 |
Balance at 1 July 2019 |  |  | 36,642 |  |  |  | 464 |  |  |  | 2,037 |  |  |  | (24,948 | ) |  |  | — |  |  |  | 14,195 |
Loss after income tax expense for the year |  |  | — |  |  |  | — |  |  |  | — |  |  |  | (12,467 | ) |  |  | — |  |  |  | (12,467 | )
Other comprehensive income for the year, net of tax |  |  | — |  |  |  | — |  |  |  | (4 | ) |  |  | — |  |  |  | — |  |  |  | (4 | )
Total comprehensive income for the year |  |  | — |  |  |  | — |  |  |  | (4 | ) |  |  | (12,467 | ) |  |  | — |  |  |  | (12,471 | )
Transactions with owners in their capacity as owners: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share issue costs |  |  | (833 | ) |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | (833 | )
Transfers |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
Conversion of convertible note |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
Employee share-based payment options |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
Share based payment |  |  | — |  |  |  | — |  |  |  | 262 |  |  |  | — |  |  |  | — |  |  |  | 262 |
Issue of shares |  |  | 12,972 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 12,972 |
Expired options |  |  | — |  |  |  | — |  |  |  | (1,230 | ) |  |  | 1,230 |  |  |  | — |  |  |  | — |
Balance at 30 June 2020 |  |  | 48,781 |  |  |  | 464 |  |  |  | 1,066 |  |  |  | (36,186 | ) |  |  | — |  |  |  | 14,125 |

The above consolidated statements of changes in equity should be read with the accompanying notes

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Consolidated statements of cash flows

For the year ended 30 June 2020

|  | Note |  |  | 2020 A$’000 |  |  | 2019 A$’000 |  |  | 2018 A$’000 |
Cash flows from operating activities |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss before income tax expense for the year |  |  |  |  |  |  | (12,467 | ) |  |  | (10,270 | ) |  |  | (6,039 | )
Adjustments for: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Depreciation and amortisation |  |  | 6 |  |  |  | 1,084 |  |  |  | 1,084 |  |  |  | 1,547 |
Net loss on disposal of non-current assets |  |  |  |  |  |  | — |  |  |  | — |  |  |  | 137 |
Impairment of property, plant and equipment |  |  |  |  |  |  | — |  |  |  | 1 |  |  |  | 143 |
Share-based payments |  |  |  |  |  |  | 262 |  |  |  | 246 |  |  |  | 165 |
Foreign exchange differences |  |  |  |  |  |  | — |  |  |  | — |  |  |  | (251 | )
Shares issued for no consideration |  |  |  |  |  |  | — |  |  |  | — |  |  |  | 30 |
Gain on legal settlement |  |  |  |  |  |  | — |  |  |  | — |  |  |  | (8,411 | )
Loss/(gain) on contingent consideration |  |  | 17 |  |  |  | 474 |  |  |  | 63 |  |  |  | (1,461 | )
Fair value loss on financial assets |  |  |  |  |  |  | 168 |  |  |  | 1,809 |  |  |  | 3,944 |
|  |  |  |  |  |  | (10,479 | ) |  |  | (7,067 | ) |  |  | (10,196 | )
Change in operating assets and liabilities: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Increase in trade and other receivables |  |  |  |  |  |  | 358 |  |  |  | 825 |  |  |  | 1,724 |
Increase/(decrease) in prepayments |  |  |  |  |  |  | (168 | ) |  |  | 398 |  |  |  | (10 | )
Increase/(decrease) in trade and other payables |  |  |  |  |  |  | 1,722 |  |  |  | (409 | ) |  |  | 88 |
Increase/(decrease) in other provisions |  |  |  |  |  |  | 55 |  |  |  | (25 | ) |  |  | (58 | )
Decrease in deferred tax liability |  |  |  |  |  |  | (298 | ) |  |  | (298 | ) |  |  | (305 | )
Increase/(decrease) in accrued revenue |  |  |  |  |  |  | — |  |  |  | (138 | ) |  |  | 97 |
Net cash used in operating activities |  |  |  |  |  |  | (8,810 | ) |  |  | (6,714 | ) |  |  | (8,660 | )
Cash flows from investing activities |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from legal settlement |  |  |  |  |  |  | — |  |  |  | — |  |  |  | 150 |
Proceeds from disposal of shares |  |  |  |  |  |  | — |  |  |  | 2,359 |  |  |  | — |
Net cash used in investing activities |  |  |  |  |  |  | — |  |  |  | 2,359 |  |  |  | 150 |
Cash flows from financing activities |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from issue of shares |  |  | 18 |  |  |  | 12,139 |  |  |  | 3,816 |  |  |  | — |
Net cash from financing activities |  |  |  |  |  |  | 12,139 |  |  |  | 3,816 |  |  |  | — |
Net decrease in cash and cash equivalents |  |  |  |  |  |  | 3,329 |  |  |  | (539 | ) |  |  | (8,511 | )
Cash and cash equivalents at the beginning of the financial year |  |  |  |  |  |  | 5,434 |  |  |  | 5,956 |  |  |  | 14,455 |
Effects of exchange rate changes on cash |  |  |  |  |  |  | — |  |  |  | 17 |  |  |  | 12 |
Cash and cash equivalents at the end of the financial year |  |  | 8 |  |  |  | 8,764 |  |  |  | 5,434 |  |  |  | 5,956 |

The above consolidated statements of changes in equity should be read with the accompanying notes

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##### Table of Contents

Notes to the financial statements

June 30, 2020

Note 1. General information

The financial statements cover Kazia Therapeutics Limited as a consolidated entity consisting of Kazia Therapeutics Limited and its subsidiaries. The financial statements are presented in Australian dollars, which is Kazia Therapeutics Limited’s functional and presentation currency.

Kazia Therapeutics Limited is a listed public company limited by shares, incorporated and domiciled in Australia. Its registered office and principal place of business is:

Three International Towers

Level 24, 300 Barangaroo Avenue

Sydney NSW 2000

The financial statements were authorised for issue, in accordance with a resolution of Directors, on 27 August 2020. The Directors have the power to amend and reissue the financial statements.

Note 2. Significant accounting policies

The principal accounting policies adopted in the preparation of the financial statements are set out below. These policies have been consistently applied to all the years presented, unless otherwise stated.

New or amended Accounting Standards and Interpretations adopted

The consolidated entity has adopted all of the new, revised or amending Accounting Standards and Interpretations issued by the International Accounting Standards Board (‘IASB’) that are mandatory for the current reporting period.

Any new, revised or amending Accounting Standards or Interpretations that are not yet mandatory have not been early adopted.

Any significant impact on the accounting policies of the consolidated entity from the adoption of these Accounting Standards and Interpretations are disclosed below. The adoption of these Accounting Standards and Interpretations did not have any significant impact on the financial performance or position of the consolidated entity.

The following Accounting Standards and Interpretations are most relevant to the consolidated entity:

IFRS 16 Leases

General impact of application of IFRS 16 Leases

IFRS 16 has been applied from 1 July 2019. The standard introduces new requirements with respect to lease accounting by removing the distinction between operating and finance leases, requiring the recognition of a right-of-use asset and a lease liability at commencement for all leases except for short-term leases, being those less than 12 months, and leases of low-value assets.

Impact of the definition of a new lease

The change in definition of a lease mainly relates to the concept of control. IFRS 16 determines whether a contract contains a lease on the basis of whether the customer has the right to control the use of an identified asset for a period of time in exchange for consideration. The consolidated entity has applied this definition to all lease contracts currently held. The new policy is set out below.

As the consolidated entity is not party to any material leases with a term in excess of 12 months, the adoption of the new standard has not had a material impact on the current period.

Interpretation 23 Uncertain tax positions

Interpretation 23 clarified the application of the recognition and measurement criteria in IAS 12 Income Taxes (IAS 12) where there is uncertainty over income tax treatments and requires an assessment of each uncertain tax position as to whether it is probable that a taxation authority will accept the position. Where it is not probable, the effect of the uncertainty is reflected in determining the relevant taxable profit or loss, tax bases, unused tax losses and unused tax credits or tax rates. The amount is determined as either the single most likely amount or the sum of the probability weighted amounts in a range of possible outcomes, whichever better predicts the resolution of the uncertainty. Judgments are reassessed as and when new facts and circumstances are presented.

Interpretation 23 is effective for the Group’s annual financial reporting period beginning on 1 July 2019. The Company is of the view that there are no material uncertain positions which impact the Group’s accounting for income taxes.

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##### Table of Contents

Notes to the financial statements

June 30, 2020

Note 2. Significant accounting policies (continued)

Going concern

The consolidated entity incurred a loss after income tax of $12,467,466 (2019: $10,270,264), was in a net current asset position of $5,586,128 (2019: net current asset position of $5,613,883) and had net cash outflows from operating activities of $8,809,519 (2019: $6,714,210) for the year ended 30 June 2020.

As at 30 June 2020 the consolidated entity had cash in hand and at bank of $8,764,044. Subsequent to year end, the consolidated entity has raised approximately A$24 million (after costs) from a fully underwritten entitlement offer to eligible shareholders.

The financial statements have been prepared on a going concern basis, which contemplates continuity of normal activities and realisation of assets and settlement of liabilities in the normal course of business.

The directors have considered the cash flow forecasts and the funding requirements of the business. In particular, the directors have considered the impact of COVID-19 on the operations of the Company, and make the following observations:

Kazia’s key clinical trials (phase II study of paxalisib in glioblastoma and phase I study of Cantrixil in ovarian cancer) were fully recruited prior to the onset of restrictions associated with COVID-19 in the United States and Australia;

• |  | The GBM AGILE study, which is planned to serve as a pivotal study for paxalisib in glioblastoma, remains on track, and initiation of recruitment continues to be expected in 2H CY2020;

• |  | In general, clinical research in advanced cancer is relatively protected from pandemic disruption due to the ongoing and time-critical need for patient care in specialised facilities that cannot easily be repurposed;

• |  | The Company is pre-revenue, and so changes in customer behaviour over the next several years due to public health restrictions and reduced economic activity have little to no impact on its finances;

• |  | The Company was able to secure funding of approximately $9 million at the height of the initial wave of COVID-19, with additional demand from institutional investors at that time, which could not be satisfied within the Company’s placement capacity;

• |  | The directors do not foresee any other impacts on the Company’s ability to raise additional funding as a result of COVID-19.

The directors are confident that the recent capital raise has provided sufficient funding to allow the consolidated entity to continue as a going concern.

Basis of preparation

These general purpose financial statements have been prepared in accordance with Australian Accounting Standards and Interpretations issued by the Australian Accounting Standards Board (‘AASB’) and the Corporations Act 2001, as appropriate for for-profit oriented entities. These financial statements also comply with International Financial Reporting Standards as issued by the International Accounting Standards Board (‘IASB’).

The financial statements have been prepared on an accruals basis and under the historical cost conventions, except for listed equity investments which are carried at fair value.

Critical accounting estimates

The preparation of the financial statements requires the use of certain critical accounting estimates. It also requires management to exercise its judgement in the process of applying the consolidated entity’s accounting policies. The areas involving a higher degree of judgement or complexity, or areas where assumptions and estimates are significant to the financial statements, are disclosed in note 3.

Parent entity information

In accordance with the Corporations Act 2001, these financial statements present the results of the consolidated entity only. Supplementary information about the parent entity is disclosed in note 29.

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##### Table of Contents

Notes to the financial statements

June 30, 2020

Note 2. Significant accounting policies (continued)

Principles of consolidation

The consolidated financial statements incorporate the assets and liabilities of all subsidiaries of Kazia Therapeutics Limited (‘company’ or ‘parent entity’) as at 30 June 2020 and the results of all subsidiaries for the year then ended. Kazia Therapeutics Limited and its subsidiaries together are referred to in these financial statements as the ‘consolidated entity’.

Subsidiaries are all those entities over which the consolidated entity has control. The consolidated entity controls an entity when the consolidated entity is exposed to, or has rights to, variable returns from its involvement with the entity and has the ability to affect those returns through its power to direct the activities of the entity. Subsidiaries are fully consolidated from the date on which control is transferred to the consolidated entity. They are de-consolidated from the date that control ceases.

Intercompany transactions, balances and unrealised gains on transactions between entities in the consolidated entity are eliminated. Unrealised losses are also eliminated unless the transaction provides evidence of the impairment of the asset transferred. Accounting policies of subsidiaries have been changed where necessary to ensure consistency with the policies adopted by the consolidated entity.

The acquisition of subsidiaries is accounted for using the acquisition method of accounting. A change in ownership interest, without the loss of control, is accounted for as an equity transaction, where the difference is between the consideration transferred and the book value.

Where the consolidated entity loses control over a subsidiary, it derecognises the assets including goodwill, liabilities and non-controlling interest in the subsidiary together with any cumulative translation differences recognised in equity. The consolidated entity recognises the fair value of the consideration received and the fair value of any investment retained together with any gain or loss in profit or loss.

Operating segments

Operating segments are presented using the ‘management approach’, where the information presented is on the same basis as the internal reports provided to the Chief Operating Decision Makers (‘CODM’). The CODM is responsible for the allocation of resources to operating segments and assessing their performance. The CODM is considered to be the Board of Directors.

Foreign currency translation

The financial statements are presented in Australian dollars, which is the consolidated entity’s functional and presentation currency.

Foreign currency transactions

Foreign currency transactions are translated into Australian dollars using the exchange rates prevailing at the dates of the transactions. Foreign exchange gains and losses resulting from the settlement of such transactions and from the translation at financial year-end exchange rates of monetary assets and liabilities denominated in foreign currencies are recognised in profit or loss.

Foreign operations

The assets and liabilities of foreign operations are translated into Australian dollars using the exchange rates at the reporting date. The revenues and expenses of foreign operations are translated into Australian dollars using the average exchange rates, which approximate the rate at the date of the transaction, for the period. All resulting foreign exchange differences are recognised in other comprehensive income through the foreign currency reserve in equity.

The foreign currency reserve is recognised in profit or loss when the foreign operation is disposed of.

Exchange differences arising on a monetary item that forms part of a reporting entity’s net investment in a foreign operation shall be recognised initially in other comprehensive income and reclassified from equity to profit or loss on disposal of the net investment.

Financial Instruments

Recognition and derecognition

Financial assets and financial liabilities are recognised when the Group becomes a party to the contractual provisions of the financial instrument and are measured initially at fair value adjusted by transactions costs, except for those carried at fair value through profit or loss, which are measured initially at fair value. Subsequent measurement of financial assets and financial liabilities are described below. Financial assets are derecognised when the contractual rights to the cash flows from the financial asset expire, or when the financial asset and substantially all the risks and rewards are transferred. A financial liability is derecognised when it is extinguished, discharged, cancelled or expires.

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##### Table of Contents

Notes to the financial statements

June 30, 2020

Note 2. Significant accounting policies (continued)

Classification and initial measurement of financial assets

Except for those trade receivables that do not contain a significant financing component and are measured at the transaction price in accordance with IFRS 15, all financial assets are initially measured at fair value adjusted for transaction costs (where applicable).

Subsequent measurement of financial assets

For the purpose of subsequent measurement, financial assets are classified into the following categories upon initial recognition:

• |  | financial assets at amortised cost

• |  | financial assets at fair value through profit or loss (FVPL)

Classifications are determined by both:

• |  | The entity’s business model for managing the financial asset

• |  | The contractual cash flow characteristics of the financial assets

All income and expenses relating to financial assets that are recognised in profit or loss are presented within finance costs, finance income or other financial items, except for impairment of trade receivables which is presented within other expenses.

Financial assets at amortised cost

Financial assets are measured at amortised cost if the assets meet the following conditions (and are not designated as FVPL):

• |  | they are held within a business model whose objective is to hold the financial assets and collect its contractual cash flows

• |  | the contractual terms of the financial assets give rise to cash flows that are solely payments of principal and interest on the principal amount outstanding

After initial recognition, these are measured at amortised cost using the effective interest method. Discounting is omitted where the effect of discounting is immaterial. The Group’s cash and cash equivalents, trade and most other receivables fall into this category of financial instruments.

Financial assets at fair value through profit or loss (FVPL)

Financial assets that are held within a business model other than ‘hold to collect’ or ‘hold to collect and sell’ are categorised at fair value through profit and loss. Further, irrespective of business model, financial assets whose contractual cash flows are not solely payments of principal and interest are accounted for at FVPL. The Group’s investments in equity instruments and derivatives fall under this category.

Impairment of financial assets

IFRS 9’s new impairment model uses more forward looking information to recognize expected credit losses - the ‘expected credit losses (ECL) model’. The application of the new impairment model depends on whether there has been a significant increase in credit risk. The Group considers a broader range of information when assessing credit risk and measuring expected credit losses, including past events, current conditions, reasonable and supportable forecasts that affect the expected collectability of the future cash flows of the instrument.

In applying this forward-looking approach, a distinction is made between:

• |  | financial instruments that have not deteriorated significantly in credit quality since initial recognition or that have low credit risk (‘Stage 1’) and

• |  | financial instruments that have deteriorated significantly in credit quality since initial recognition and whose credit risk is not low (‘Stage 2’).

‘Stage 3’ would cover financial assets that have objective evidence of impairment at the reporting date. ‘12-month expected credit losses’ are recognised for the first category while ‘lifetime expected credit losses’ are recognised for the second category. Measurement of the expected credit losses is determined by a probability-weighted estimate of credit losses over the expected life of the financial instrument.

Classification and measurement of financial liabilities

The Group’s financial liabilities comprise trade and other payables. Financial liabilities are initially measured at fair value, and, where applicable, adjusted for transaction costs unless the Group designated a financial liability at fair value through profit or loss. Subsequently, financial liabilities are measured at amortised cost using the effective interest method.

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##### Table of Contents

Notes to the financial statements

June 30, 2020

Note 2. Significant accounting policies (continued)

All interest-related charges and, if applicable, changes in an instrument’s fair value that are reported in profit or loss are included within finance costs or finance income.

Revenue from contracts with customers

The Group does not earn revenue from contracts with customers.

Finance Income

Interest revenue is recognised as interest accrues using the effective interest method. This is a method of calculating the amortised cost of a financial asset and allocating the interest income over the relevant period using the effective interest rate, which is the rate that exactly discounts estimated future cash receipts through the expected life of the financial asset to the net carrying amount of the financial asset.

Grant income

The R&D Tax Incentive is a government program which helps to offset some of the incurred costs of R&D. Eligible expenditure incurred under the scheme in a financial year attracts an additional 43.5% tax deduction, and for a group earning income of less than $20 million, the cash value of the additional deduction is remitted to the taxpayer. In accordance with AASB 120, as the compensation relates to expenses already incurred, it is recognised in profit or loss of the period in which it becomes receivable. Accordingly the group accounts for the R&D Tax Incentive in the same year as the expenses to which it relates.

Other revenue

Other revenue is recognised when it is received or when the right to receive payment is established.

Income tax

The income tax expense or benefit for the period is the tax payable on that period’s taxable income based on the applicable income tax rate for each jurisdiction, adjusted by changes in deferred tax assets and liabilities attributable to temporary differences, unused tax losses and the adjustment recognised for prior periods, where applicable.

Deferred tax assets and liabilities are recognised for temporary differences at the tax rates expected to apply when the assets are recovered or liabilities are settled, based on those tax rates that are enacted or substantively enacted, except for:

• |  | When the deferred income tax asset or liability arises from the initial recognition of goodwill or an asset or liability in a transaction that is not a business combination and that, at the time of the transaction, affects neither the accounting nor taxable profits; or

• |  | When the taxable temporary difference is associated with interests in subsidiaries, associates or joint ventures, and the timing of the reversal can be controlled and it is probable that the temporary difference will not reverse in the foreseeable future.

Deferred tax assets are recognised for deductible temporary differences and unused tax losses only if it is probable that future taxable amounts will be available to utilise those temporary differences and losses.

The carrying amount of recognised and unrecognised deferred tax assets are reviewed each reporting date. Deferred tax assets recognised are reduced to the extent that it is no longer probable that future taxable profits will be available for the carrying amount to be recovered. Previously unrecognised deferred tax assets are recognised to the extent that it is probable that there are future taxable profits available to recover the asset.

Deferred tax assets and liabilities are offset only where there is a legally enforceable right to offset current tax assets against current tax liabilities and deferred tax assets against deferred tax liabilities; and they relate to the same taxable authority on either the same taxable entity or different taxable entities which intend to settle simultaneously.

Kazia Therapeutics Limited (the ‘parent entity’) and its wholly-owned Australian controlled entities have formed an income tax consolidated group under the tax consolidation regime. Kazia Therapeutics Limited as the parent entity discloses all of the deferred tax assets of the tax consolidated group in relation to tax losses carried forward (after elimination of inter-group transactions). The tax consolidated group has applied the ‘separate taxpayer in the group’ allocation approach in determining the appropriate amount of taxes to allocate to members of the tax consolidated group.

As the tax consolidation group continues to generate tax losses there has been no reason for the company to enter a tax funding agreement with members of the tax consolidation group.

Interpretation 23 Uncertain tax positions

Interpretation 23 clarified the application of the recognition and measurement criteria in IAS 12 Income Taxes (IAS 12) where there is uncertainty over income tax treatments and requires an assessment of each uncertain tax position as to whether it is probable that a taxation authority will accept the position. Where it is not probable, the effect of the uncertainty is reflected in determining the relevant taxable profit or loss, tax bases, unused tax losses and unused tax credits or tax rates. The amount is determined as either the single most likely amount or the sum of the probability weighted amounts in a range of possible outcomes, whichever better predicts the resolution of the uncertainty. Judgments are reassessed as and when new facts and circumstances are presented.

F-13

##### Table of Contents

Notes to the financial statements

June 30, 2020

Note 2. Significant accounting policies (continued)

Current and non-current classification

Assets and liabilities are presented in the statement of financial position based on current and non-current classification.

An asset is current when: it is expected to be realised or intended to be sold or consumed in normal operating cycle; it is held primarily for the purpose of trading; it is expected to be realised within 12 months after the reporting period; or the asset is cash or cash equivalent unless restricted from being exchanged or used to settle a liability for at least 12 months after the reporting period. All other assets are classified as non-current.

A liability is current when: it is expected to be settled in normal operating cycle; it is held primarily for the purpose of trading; it is due to be settled within 12 months after the reporting period; or there is no unconditional right to defer the settlement of the liability for at least 12 months after the reporting period. All other liabilities are classified as non-current.

Deferred tax assets and liabilities are always classified as non-current.

Cash and cash equivalents

Cash and cash equivalents includes cash on hand, deposits held at call with financial institutions, other short-term, highly liquid investments with original maturities of three months or less that are readily convertible to known amounts of cash and which are subject to an insignificant risk of changes in value.

Research and development

Expenditure during the research phase of a project is recognised as an expense when incurred. Development costs are capitalised only when technical feasibility studies identify that the project will deliver future economic benefits and these benefits can be measured reliably.

Leases

Under IFRS 16, leases are accounted for as follows:

• |  | Right-of-use assets and lease liabilities are recognised in the consolidated statement of financial position, initially measured at the present value of future lease payments;

• |  | Depreciation on right-of-use assets and interest on lease liabilities are recognised in the consolidated statement of profit or loss; and

• |  | The total amount of cash paid under lease arrangements is separated into a principal portion (presented within financing activities) and interest (presented within operating activities) in the consolidated cash flow statement.

Lease incentives under IFRS 16 are recognised as part of the measurement of right-of-use assets and lease liabilities. Under IFRS 16, right-of-use assets are tested for impairment in accordance with IAS 36 Impairment of Assets. This replaces the previous requirement to recognise a provision for onerous lease contracts.

For short-term leases (lease term of 12 months or less) and leases of low-value assets, the consolidated entity has opted to recognise a lease expense on a straight-line basis as permitted by IFRS 16. This expense is presented within other expenses in the consolidated statement of profit or loss.

Intangible assets

Intangible assets acquired as part of a business combination, other than goodwill, are initially measured at their fair value at the date of the acquisition. Intangible assets acquired separately are initially recognised at cost. Indefinite life intangible assets are not amortised and are subsequently measured at cost less any impairment. Finite life intangible assets are subsequently measured at cost less amortisation and any impairment. The gains or losses recognised in profit or loss arising from derecognition of intangible assets are measured as the difference between net disposal proceeds and the carrying amount of the intangible asset. The method and useful lives of finite life intangible assets are reviewed annually. Changes in the expected pattern of consumption or useful life are accounted for prospectively by changing the amortisation method or period.

Patents and trademarks

Significant costs associated with patents and intellectual property are deferred and amortised on a straight-line basis over the period of their expected benefit, being their finite useful life of 5 years.

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##### Table of Contents

Notes to the financial statements

June 30, 2020

Note 2. Significant accounting policies (continued)

Licensing agreement for GDC-0084

The Licensing Agreement asset was initially brought to account at fair value, and is being amortised on a straight-line basis over the period of its expected benefit, being the remaining life of the patent, which was 15 years from the date of acquisition.

Impairment of non-financial assets

Non-financial assets with finite useful lives are reviewed for impairment whenever events or changes in circumstances indicate that the carrying amount may not be recoverable. An impairment loss is recognised for the amount by which the asset’s carrying amount exceeds its recoverable amount.

Recoverable amount is the higher of an asset’s fair value less costs of disposal and value-in-use. The value-in-use is the present value of the estimated future cash flows relating to the asset using a pre-tax discount rate specific to the asset or cash-generating unit to which the asset belongs. Assets that do not have independent cash flows are grouped together to form a cash-generating unit.

Compound financial instruments

Subsequent to initial recognition, the liability component of a compound financial instrument is measured at amortised cost using the effective interest rate method, whereas the equity component is not remeasured. Interest, gains and losses relating to the financial liability are recognised in profit or loss. On conversion, the financial liability is reclassified to equity; no gain or loss is recognised on conversion.

Provisions

Provisions are recognised when the consolidated entity has a present (legal or constructive) obligation as a result of a past event, it is probable the consolidated entity will be required to settle the obligation, and a reliable estimate can be made of the amount of the obligation. The amount recognised as a provision is the best estimate of the consideration required to settle the present obligation at the reporting date, taking into account the risks and uncertainties surrounding the obligation. If the time value of money is material, provisions are discounted using a current pre-tax rate specific to the liability. The increase in the provision resulting from the passage of time is recognised as a finance cost.

Employee benefits

Short-term employee benefits

Liabilities for wages and salaries, including non-monetary benefits, annual leave and long service leave expected to be settled within 12 months of the reporting date are measured at the amounts expected to be paid when the liabilities are settled.

Other long-term employee benefits

The liability for annual leave and long service leave not expected to be settled within 12 months of the reporting date is measured as the present value of expected future payments to be made in respect of services provided by employees up to the reporting date using the projected unit credit method. Consideration is given to expected future wage and salary levels, experience of employee departures and periods of service. Expected future payments are discounted using market yields at the reporting date on high quality corporate bonds with terms to maturity and currency that match, as closely as possible, the estimated future cash outflows.

Defined contribution superannuation expense

Contributions to defined contribution superannuation plans are expensed in the period in which they are incurred.

Share-based payments

Equity-settled share-based compensation benefits are provided to employees under the terms of the Employee Share Option Plan (‘ESOP’) and consultants as compensation for services performed.

Equity-settled transactions are awards of shares, or options over shares that are provided to employees in exchange for the rendering of services.

The cost of equity-settled transactions are measured at fair value on grant date. Fair value is independently determined using the Black-Scholes option pricing model that takes into account the exercise price, the term of the option, the impact of dilution, the share price at grant date and expected price volatility of the underlying share, the expected dividend yield and the risk free interest rate for the term of the option, together with non-vesting conditions that do not determine whether the consolidated entity receives the services that entitle the employees to receive payment. No account is taken of any other vesting conditions.

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##### Table of Contents

Notes to the financial statements

June 30, 2020

Note 2. Significant accounting policies (continued)

The cost of equity-settled transactions are recognised as an expense with a corresponding increase in equity over the vesting period. The cumulative charge to profit or loss is calculated based on the grant date fair value of the award, the best estimate of the number of awards that are likely to vest and the expired portion of the vesting period. The amount recognised in profit or loss for the period is the cumulative amount calculated at each reporting date less amounts already recognised in previous periods.

The cumulative charge to profit or loss until settlement of the liability is calculated as follows:

• |  | during the vesting period, the liability at each reporting date is the fair value of the award at that date multiplied by the expired portion of the vesting period.

• |  | from the end of the vesting period until settlement of the award, the liability is the full fair value of the liability at the reporting date.

Market conditions are taken into consideration in determining fair value. Therefore any awards subject to market conditions are considered to vest irrespective of whether or not that market condition has been met, provided all other conditions are satisfied.

If equity-settled awards are modified, as a minimum an expense is recognised as if the modification has not been made. An additional expense is recognised, over the remaining vesting period, for any modification that increases the total fair value of the share-based compensation benefit as at the date of modification.

If the non-vesting condition is within the control of the consolidated entity or employee, the failure to satisfy the condition is treated as a cancellation. If the condition is not within the control of the consolidated entity or employee and is not satisfied during the vesting period, any remaining expense for the award is recognised over the remaining vesting period, unless the award is forfeited.

If equity-settled awards are cancelled, it is treated as if it has vested on the date of cancellation, and any remaining expense is recognised immediately. If a new replacement award is substituted for the cancelled award, the cancelled and new award is treated as if they were a modification.

Finance costs

Finance costs attributable to qualifying assets are capitalised as part of the asset. All other finance costs are expensed in the period in which they are incurred, including interest on short-term and long-term borrowings.

Fair value measurement

When an asset or liability, financial or non-financial, is measured at fair value for recognition or disclosure purposes, the fair value is based on the price that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date; and assumes that the transaction will take place either: in the principal market; or in the absence of a principal market, in the most advantageous market.

Fair value is measured using the assumptions that market participants would use when pricing the asset or liability, assuming they act in their economic best interest. For non-financial assets, the fair value measurement is based on its highest and best use. Valuation techniques that are appropriate in the circumstances and for which sufficient data are available to measure fair value, are used, maximising the use of relevant observable inputs and minimising the use of unobservable inputs.

Assets and liabilities measured at fair value are classified, into three levels, using a fair value hierarchy that reflects the significance of the inputs used in making the measurements. Classifications are reviewed each reporting date and transfers between levels are determined based on a reassessment of the lowest level input that is significant to the fair value measurement.

For recurring and non-recurring fair value measurements, external valuers may be used when internal expertise is either not available or when the valuation is deemed to be significant. External valuers are selected based on market knowledge and reputation. Where there is a significant change in fair value of an asset or liability from one period to another, an analysis is undertaken, which includes a verification of the major inputs applied in the latest valuation and a comparison, where applicable, with external sources of data.

Issued capital

Ordinary shares are classified as equity.

Incremental costs directly attributable to the issue of new shares or options, including share based payments relating to the issue of shares are, shown in equity as a deduction, net of tax, from the proceeds.

F-16

##### Table of Contents

Notes to the financial statements

June 30, 2020

Note 2. Significant accounting policies (continued)

Earnings per share

Basic earnings per share

Basic earnings per share is calculated by dividing the profit attributable to the owners of Kazia Therapeutics Limited, excluding any costs of servicing equity other than ordinary shares, by the weighted average number of ordinary shares outstanding during the financial year, adjusted for bonus elements in ordinary shares issued during the financial year.

Diluted earnings per share

Diluted earnings per share adjusts the figures used in the determination of basic earnings per share to take into account the after income tax effect of interest and other financing costs associated with dilutive potential ordinary shares and the weighted average number of shares assumed to have been issued for no consideration in relation to dilutive potential ordinary shares.

Goods and Services Tax (‘GST’) and other similar taxes

Revenues, expenses and assets are recognised net of the amount of associated GST, unless the GST incurred is not recoverable from the tax authority. In this case it is recognised as part of the cost of the acquisition of the asset or as part of the expense.

Receivables and payables are stated inclusive of the amount of GST receivable or payable. The net amount of GST recoverable from, or payable to, the tax authority is included in other receivables or other payables in the statement of financial position.

Cash flows are presented on a gross basis. The GST components of cash flows arising from investing or financing activities which are recoverable from, or payable to the tax authority, are presented as operating cash flows.

Commitments and contingencies are disclosed net of the amount of GST recoverable from, or payable to, the tax authority.

New Accounting Standards and Interpretations not yet mandatory or early adopted

Australian Accounting Standards and Interpretations that have recently been issued or amended but are not yet mandatory, have not been early adopted by the consolidated entity for the annual reporting period ended 30 June 2020. The consolidated entity’s assessment of the impact of these new or amended Accounting Standards and Interpretations is that none are deemed to have a material impact on the entity.

Note 3. Critical accounting judgements, estimates and assumptions

The preparation of the financial statements requires management to make judgements, estimates and assumptions that affect the reported amounts in the financial statements. Management continually evaluates its judgements and estimates in relation to assets, liabilities, contingent liabilities, revenue and expenses. Management bases its judgements, estimates and assumptions on historical experience and on other various factors, including expectations of future events, management believes to be reasonable under the circumstances. The resulting accounting judgements and estimates will seldom equal the related actual results. The judgements, estimates and assumptions that have a significant risk of causing a material adjustment to the carrying amounts of assets and liabilities (refer to the respective notes) within the next financial year are discussed as follows:

Research and development expenses

The Directors do not consider the development programs to be sufficiently advanced to reliably determine the economic benefits and technical feasibility to justify capitalisation of development costs. These costs have been recognised as an expense when incurred.

Research and development expenses relate primarily to the cost of conducting human clinical and pre-clinical trials. Clinical development costs are a significant component of research and development expenses. Estimates have been used in determining the expense liability under certain clinical trial contracts where services have been performed but not yet invoiced. Generally the costs, and therefore estimates, associated with clinical trial contracts are based on the number of patients, drug administration cycles, the type of treatment and the outcome being measured. The length of time before actual amounts can be determined will vary depending on length of the patient cycles and the timing of the invoices by the clinical trial partners.

Clinical trial expenses

Estimates have been used in determining the expense liability under certain clinical trial contracts being performed but not yet invoiced.

F-17

##### Table of Contents

Notes to the financial statements

June 30, 2020

Note 3. Critical accounting judgements, estimates and assumptions (continued)

Share-based payment transactions

The consolidated entity measures the cost of equity-settled transactions with employees by reference to the fair value of the equity instruments at the date at which they are granted. The fair value is determined by using the Black-Scholes model taking into account the terms and conditions upon which the instruments were granted. The accounting estimates and assumptions relating to equity-settled share-based payments would have no impact on the carrying amounts of assets and liabilities within the next annual reporting period but may impact profit or loss and equity.

Fair value measurement hierarchy

The consolidated entity is required to classify all assets and liabilities, measured at fair value, using a three level hierarchy, based on the lowest level of input that is significant to the entire fair value measurement, being: Level 1: Quoted prices (unadjusted) in active markets for identical assets or liabilities that the entity can access at the measurement date; Level 2: Inputs other than quoted prices included within Level 1 that are observable for the asset or liability, either directly or indirectly; and Level 3: Unobservable inputs for the asset or liability. Considerable judgement is required to determine what is significant to fair value and therefore which category the asset or liability is placed in can be subjective.

Research and development tax rebate

The R&D Tax Incentive is recognised when a reliable estimate of the amounts receivable can be made. For the year ended 30 June 2020 the group has estimated the rebate which will be received in early 2021 and has accrued that amount as income in the statement of profit or loss and other comprehensive income.

Impairment of non-financial assets other than goodwill and other indefinite life intangible assets

The consolidated entity assesses impairment of non-financial assets other than goodwill and other indefinite life intangible assets at each reporting date by evaluating conditions specific to the consolidated entity and to the particular asset that may lead to impairment. If an impairment trigger exists, the recoverable amount of the asset is determined.

Recovery of deferred tax assets

Deferred tax assets are recognised for deductible temporary differences only if the consolidated entity considers it is probable that future taxable amounts will be available to utilise those temporary differences and losses. There have been no deferred tax assets recognised in the financial statements.

Business combinations

The consolidated entity entered into a business combination in a prior year. The transaction was complex, involving the licensing of an asset from one party and the purchase of a company from another party. Significant judgement was required in determining that the transaction was a business combination and in relation to the identification and valuation of assets and liabilities acquired.

Contingent consideration

The fair value of contingent consideration is dependent on the key assumptions including probability of milestones occurring, timing of settlement and discount rates.

Note 4. Operating segments

Identification of reportable operating segments

The consolidated entity’s operating segment is based on the internal reports that are reviewed and used by the Board of Directors (being the Chief Operating Decision Makers (‘CODM’)) in assessing performance and in determining the allocation of resources.

The consolidated entity operates in the pharmaceutical research and development business. There are no operating segments for which discrete financial information exists.

The information reported to the CODM, on at least a quarterly basis, is the consolidated results as shown in the statement of profit or loss and other comprehensive income and statement of financial position.

Major customers

During the current and prior financial year there were no major customers.

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##### Table of Contents

Notes to the financial statements

June 30, 2020

Note 5. Other income

|  | Consolidated |
|  | 2020 A$’000 |  |  | 2019 A$’000 |  |  | 2018 A$’000 |
Net foreign exchange gain |  |  | 5 |  |  |  | — |  |  |  | 224 |
Payroll tax rebate |  |  | 2 |  |  |  | — |  |  |  | — |
Subsidies and grants |  |  | 20 |  |  |  | 9 |  |  |  | 685 |
Gain on legal settlement |  |  | — |  |  |  | — |  |  |  | 8,411 |
Reimbursement of expenses |  |  | — |  |  |  | 25 |  |  |  | 8 |
Research and development rebate |  |  | 968 |  |  |  | 1,431 |  |  |  | 2,200 |
Other sundry income |  |  | — |  |  |  | — |  |  |  | 1,461 |
Other income |  |  | 995 |  |  |  | 1,465 |  |  |  | 12,989 |

Note 6. Expenses

|  | Consolidated |
|  | 2020 |  |  | 2019 |  |  | 2018 |
|  | A$’000 |  |  | A$’000 |  |  | A$’000 |
Loss before income tax includes the following specific |  |  |  |  |  |  |  |  |  |  |  |
Depreciation |  |  |  |  |  |  |  |  |  |  |  |
Leasehold improvements |  |  | — |  |  |  | — |  |  |  | 192 |
Property, plant and equipment |  |  | — |  |  |  | — |  |  |  | 19 |
Total depreciation |  |  | — |  |  |  | — |  |  |  | 211 |
Amortisation |  |  |  |  |  |  |  |  |  |  |  |
Patents and intellectual property |  |  | — |  |  |  | — |  |  |  | 250 |
Software |  |  | — |  |  |  | — |  |  |  | 2 |
GDC licensing agreement |  |  | 1,084 |  |  |  | 1,084 |  |  |  | 1,084 |
Total amortisation |  |  | 1,084 |  |  |  | 1,084 |  |  |  | 1,336 |
Total depreciation and amortisation |  |  | 1,084 |  |  |  | 1,084 |  |  |  | 1,547 |
Impairment |  |  |  |  |  |  |  |  |  |  |  |
Leasehold Improvements |  |  | — |  |  |  | — |  |  |  | 143 |
Rental expense relating to operating leases |  |  |  |  |  |  |  |  |  |  |  |
Minimum lease payments |  |  | 108 |  |  |  | 79 |  |  |  | 301 |
Superannuation expense |  |  |  |  |  |  |  |  |  |  |  |
Defined contribution superannuation expense |  |  | 140 |  |  |  | 128 |  |  |  | 170 |
Employee benefits expense excluding superannuation |  |  |  |  |  |  |  |  |  |  |  |
Employee benefits expense excluding superannuation |  |  | 1,526 |  |  |  | 1,396 |  |  |  | 2,213 |
Other Expenses |  |  |  |  |  |  |  |  |  |  |  |
Revaluation of contingent consideration |  |  | 475 |  |  |  | 63 |  |  |  | — |

F-19

##### Table of Contents

Notes to the financial statements

June 30, 2020

Note 7. Income tax benefit

|  | 2020 |  |  | 2019 |  |  | 2018 |
|  | A$’000 |  |  | A$’000 |  |  | A$’000 |
Numerical reconciliation of income tax benefit and tax at the statutory rate |  |  |  |  |  |  |  |  |  |  |  |
Loss before income tax benefit |  |  | (12,765 | ) |  |  | (10,568 | ) |  |  | (6,344 | )
Tax at the statutory tax rate of 27.5% |  |  | (3,511 | ) |  |  | (2,906 | ) |  |  | (1,745 | )
Tax effect amounts which are not deductible/(taxable) in calculating taxable income: |  |  | — |  |  |  | — |  |  |  | — |
Impact of foreign tax rate differential |  |  |  |  |  |  |  |  |  |  |  |
Research and Development claim |  |  | 280 |  |  |  | 394 |  |  |  | 605 |
Capitalised expenses |  |  | — |  |  |  | — |  |  |  | — |
Employee option plan |  |  | 72 |  |  |  | 67 |  |  |  | 45 |
Gain/loss on revaluation of contingent consideration |  |  | 131 |  |  |  | 17 |  |  |  | (401 | )
Other non-deductible expenses |  |  | — |  |  |  | — |  |  |  | — |
|  |  | (3,028 | ) |  |  | (2,428 | ) |  |  | (1,496 | )
Prior year tax losses not recognised now recouped |  |  | — |  |  |  | — |  |  |  | — |
Tax losses and timing differences not recognised |  |  | 2,730 |  |  |  | 2,130 |  |  |  | 1,191 |
Income tax benefit |  |  | (298 | ) |  |  | (298 | ) |  |  | (305 | )
|  | 2020 |  |  | 2019 |  |  | 2018 |
|  | A$’000 |  |  | A$’000 |  |  | A$’000 |
Tax losses not recognised |  |  |  |  |  |  |  |  |  |  |  |
Unused tax losses for which no deferred tax asset has been recognised-Australia |  |  | 67,430 |  |  |  | 57,050 |  |  |  | 50,331 |
Potential tax benefit @ 27.5% - Australia |  |  | 18,543 |  |  |  | 15,689 |  |  |  | 13,841 |
Unused tax losses for which no deferred tax asset has been recognised-US |  |  | 1,570 |  |  |  | 2,366 |  |  |  | 2,525 |
Potential tax benefit at statutory tax rates@21%-US |  |  | 330 |  |  |  | 497 |  |  |  | 530 |

Note 8. Current assets - cash and cash equivalents

|  | 2020 |  |  | 2019 |
|  | A$’000 |  |  | A$’000 |
Cash at bank and on hand |  |  | 1,264 |  |  |  | 834 |
Short-term deposits |  |  | 7,500 |  |  |  | 4,600 |
|  |  | 8,764 |  |  |  | 5,434 |

Note 9. Current assets - trade and other receivables

|  | 2020 |  |  | 2019 |
|  | A$’000 |  |  | A$’000 |
Trade receivables |  |  | — |  |  |  | 17 |
Less: Provision for impairment of receivables |  |  | — |  |  |  | (17 | )
R&D tax rebate receivable |  |  | 1,017 |  |  |  | 1,440 |
|  |  | 1,017 |  |  |  | 1,440 |
Other receivables |  |  | 177 |  |  |  | 112 |
Deposits held |  |  | 567 |  |  |  | 564 |
Less: Provision for impairment of deposits held |  |  | (409 | ) |  |  | (405 | )
|  |  | 1,352 |  |  |  | 1,711 |

Deposits held included a guarantee to the value of €250,000 (A$409,098) for the “APO Trend” case. Please refer to note 26 for further information on this matter.

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##### Table of Contents

Notes to the financial statements

June 30, 2020

Note 9. Current assets - trade and other receivables (continued)

Allowance for expected credit losses

The consolidated entity has recognised a loss of nil (2019:A$16,767) in profit or loss in respect of impairment of receivables (excluding ‘deposits held’) for the year ended 30 June 2020.

Note 10. Current assets - other

|  | 2020 |  |  | 2019 |
|  | A$’000 |  |  | A$’000 |
Prepayments |  |  | 537 |  |  |  | 370 |

Note 11. Non-current assets - Financial assets

|  | 2020 |  |  | 2019 |
|  | A$’000 |  |  | A$’000 |
Listed ordinary shares - FVTPL |  |  | — |  |  |  | 25 |
Unlisted shares and options - FVTPL |  |  | — |  |  |  | 143 |
|  |  | — |  |  |  | 168 |

Refer to note 23 for further information on fair value measurement.

Note 12. Non-current assets - intangibles

|  | Consolidated |
|  | 2020 |  |  | 2019 |
|  | A$’000 |  |  | A$’000 |
Patents and intellectual property - at cost |  |  | 2,851 |  |  |  | 2,851 |
Less: Accumulated amortisation |  |  | (2,851 | ) |  |  | (2,851 | )
|  |  | — |  |  |  | — |
Licensing agreement - at acquired fair value |  |  | 16,408 |  |  |  | 16,408 |
Less: Accumulated amortisation |  |  | (3,997 | ) |  |  | (2,914 | )
|  |  | 12,410 |  |  |  | 13,494 |
|  |  | 12,410 |  |  |  | 13,494 |

Reconciliations

Reconciliations of the written down values at the beginning and end of the current and previous financial year are set out below:

|  | Paxalisib licensing agreement A$’000 |  |  | Total A$’000 |
Balance at 1 July 2018 |  |  | 14,579 |  |  |  | 14,579 |
Additions |  |  |  |  |  |  |  |
Disposals |  |  |  |  |  |  |  |
Amortisation expense |  |  | (1,084 | ) |  |  | (1,084 | )
Balance at 30 June 2019 |  |  | 13,494 |  |  |  | 13,494 |
Amortisation expense |  |  | (1,084 | ) |  |  | (1,084 | )
Balance at 30 June 2020 |  |  | 12,410 |  |  |  | 12,410 |

F-21

##### Table of Contents

Notes to the financial statements

June 30, 2020

Note 13. Current liabilities - trade and other payables

|  | 2020 |  |  | 2019 |
|  | A$’000 |  |  | A$’000 |
Trade payables |  |  | 1,694 |  |  |  | 1,050 |
Accrued payables |  |  | 1,795 |  |  |  | 714 |
Other current liability |  |  | — |  |  |  | — |
|  |  | 3,489 |  |  |  | 1,764 |

Refer to note 22 for further information on financial instruments.

Note 14. Current liabilities - provisions

|  | 2020 |  |  | 2019 |
|  | A$’000 |  |  | A$’000 |
Employee benefits |  |  | 191 |  |  |  | 136 |
|  |  | 191 |  |  |  | 136 |

Note 15. Current liabilities - Contingent consideration

|  | 2020 A$’000 |  |  | 2019 A$’000 |
Contingent consideration |  |  | 1,387 |  |  |  | — |

Note 16. Non-current liabilities - deferred tax

|  | 2020 |  |  | 2019 |
|  | A$’000 |  |  | A$’000 |
Deferred tax liability associated with Licensing Agreement |  |  | 3,413 |  |  |  | 3,711 |
Amount expected to be settled within 12 months |  |  | 298 |  |  |  | 298 |
Amount expected to be settled after more than 12 months |  |  | 3,115 |  |  |  | 3,413 |
|  |  | 3,413 |  |  |  | 3,711 |

Note 17. Non-current liabilities - Contingent consideration

|  | 2020 A$’000 |  |  | 2019 A$’000 |
Contingent consideration |  |  | 458 |  |  |  | 1,370 |
|  |  | 458 |  |  |  | 1,370 |

During the 2017 financial year, the consolidated entity acquired 100% of the issued shares in Glioblast Pty Ltd, a privately-held, neuro-oncology-focused Australian biotechnology company. On the same day, Kazia entered into a worldwide licensing agreement with Genentech to develop and commercialise GDC-0084, now known as paxalisib.

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##### Table of Contents

Notes to the financial statements

June 30, 2020

Note 17. Non-current liabilities - Contingent consideration (continued)

The Glioblast acquisition contains four contingent milestone payments, the first two milestone payments are to be settled with Kazia shares, and the third and fourth milestone payments are to be settled with either cash or Kazia shares at the discretion of Kazia. Milestone 1 has now been paid out, and Milestone 3 has lapsed.

The Genentech Agreement comprises of one milestone payment payable on the first commercial licensed product sale.

The range of outcomes of contingent consideration are summarised below:

Milestone |  | Contingent Consideration |
Milestone 2 |  |  | 1,250,000 |  |  |  | 1,250,000 |
Milestone 4 |  |  | 4,199,000 |  |  |  | 3,400,000 |
Milestone 5 |  |  | 1,394,000 |  |  |  | 1,394,000 |
Total |  |  | 6,843,000 |  |  |  | 6,044,000 |

Each milestone payment is probability weighted for valuation purposes. The milestone payments are discounted to present value, using a discount rate of 35% per annum, if they are expected to be achieved more than 12 months after the valuation date. The contingent consideration was revalued at 30 June 2020 to take into account revised estimated probabilities and timelines of certain milestones being achieved, and a portion of the discount has unwound with the resultant loss on contingent consideration being recognised in profit and loss.

Kazia is also required to pay royalties to Genentech in relation to net sales. These payments are related to future financial performance, and are not considered as part of the consideration in relation to the Genentech Agreement.

Note 18. Equity - contributed equity

|  | Consolidated |
|  | 2020 Shares |  |  | 2019 Shares |  |  | 2020 $ |  |  | 2019 $ |
Ordinary shares - fully paid |  |  | 94,598,369 |  |  |  | 62,166,673 |  |  |  | 48,781,214 |  |  |  | 36,641,519 |

Movements in Ordinary share capital

Details |  | Date |  | Shares |  |  | Issue price |  |  | $ |
Balance |  | 1 July 2018 |  |  | 48,409,621 |  |  |  |  |  |  |  | 31,575,824 |
Share placement |  | 24 October 2018 |  |  | 8,900,001 |  |  | $ | 0.380 |  |  |  | 3,382,000 |
Milestone 1 shares issued in connection with purchase of Glioblast Pty Limited (GDC-0084) |  | 9 November 2018 |  |  | 2,820,824 |  |  | $ | 0.440 |  |  |  | 1,250,000 |
Issued under Share Purchase Plan |  | 23 November 2018 |  |  | 2,036,227 |  |  | $ | 0.380 |  |  |  | 773,760 |
Share issue transaction costs |  |  |  |  | — |  |  | $ | 0.000 |  |  |  | (340,065 | )
Balance |  | 30 June 2019 |  |  | 62,166,673 |  |  |  |  |  |  |  | 36,641,519 |
Share placement |  | 1 November 2019 |  |  | 10,000,000 |  |  | $ | 0.400 |  |  |  | 4,000,000 |
Share placement |  | 16 April 2020 |  |  | 18,041,667 |  |  | $ | 0.400 |  |  |  | 7,216,667 |
Issued under the Share Purchase Plan |  | 11 May 2020 |  |  | 4,390,010 |  |  | $ | 0.400 |  |  |  | 1,756,004 |
Issued on conversion of options |  |  |  |  | 19 |  |  | $ | 4.000 |  |  |  | 76 |
Share issue transaction costs |  |  |  |  | — |  |  | $ | 0.000 |  |  |  | (833,052 | )
Balance |  | 30 June 2020 |  |  | 94,598,369 |  |  |  |  |  |  |  | 48,781,214 |

Ordinary shares

Ordinary shares entitle the holder to participate in dividends and the proceeds on the winding up of the company in proportion to the number of and amounts paid on the shares held. The fully paid ordinary shares have no par value and the company does not have a limited amount of authorised capital.

On a show of hands every member present at a meeting in person or by proxy shall have one vote and upon a poll each share shall have one vote.

Share buy-back

There is no current on-market share buy-back.

F-23

##### Table of Contents

Notes to the financial statements

June 30, 2020

Note 18. Equity - contributed equity (continued)

Capital risk management

The consolidated entity’s objectives when managing capital are to safeguard its ability to continue as a going concern, so that it can provide returns for shareholders and benefits for other stakeholders and to maintain an optimum capital structure to reduce the cost of capital.

Capital is regarded as total equity, as recognised in the statement of financial position, plus net debt. Net debt is calculated as total borrowings less cash and cash equivalents.

The capital structure of the consolidated entity consists of cash and cash equivalents and equity attributable to equity holders. The overall strategy of the consolidated entity is to continue its drug development programs, which depends on raising sufficient funds, through a variety of sources including issuing of additional share capital, as may be required from time to time.

The capital risk management policy remains unchanged from the prior year.

Note 19. Equity - Other contributed equity

|  | 2019 |  |  | 2018 |
|  | $ |  |  | $ |
Convertible note - Triaxial |  |  | 464,000 |  |  |  | 464,000 |

On 4 December 2014, the consolidated entity and the convertible note holder (‘Triaxial’) signed a Convertible Note Deed Poll (‘Deed’) which superseded the precedent Loan Agreement between Triaxial shareholders and the consolidated entity. The Deed extinguishes the liability created by the Loan Agreement and provides that the Convertible Notes will convert into a pre-determined number of ordinary shares on the achievement of defined milestones established in the schedule of the Deed. Accordingly the convertible note has been reclassified as an equity instrument rather than debt instrument.

During the Financial year ended 30 June 2017, the Company reached two milestones triggering the conversion of a portion of its convertible note as follows;

• On 11 August 2016 the Company announced the submission of an IND application. On 10 September 2016, the Company received a letter from the FDA advising the study may proceed triggering conversion of 20,000,000 ordinary shares.

• On 31 October 2016, the Company announced it had licensed a Phase II ready molecule triggering the conversion of 16,000,000 ordinary shares.

During the financial year ended 30 June 2018, a portion of the convertible notes was extinguished.

The remaining portion of the convertible note will be exercised at the holders’ discretion on completion of Phase II clinical trial or achieving Breakthrough Designation, and would convert to 1,856,000 ordinary shares if converted. Completion will be deemed to occur upon the receipt by the consolidated entity of a signed study report or notification of the designation. There is a possibility for an early conversion of the convertible notes if a third party acquires more than 50% of the issued capital of the consolidated entity.

Note 20. Equity - reserves

Foreign currency translation reserve

The reserve is used to recognise exchange differences arising from translation of the financial statements of foreign operations to Australian dollars.

Share-based payments reserve

The reserve is used to recognise the value of equity benefits provided to employees and executive directors as part of their remuneration, and other parties as part of their compensation for services.

Note 21. Equity - dividends

Dividends

There were no dividends paid, recommended or declared during the current or previous financial year.

F-24

##### Table of Contents

Notes to the financial statements

June 30, 2020

Note 21. Equity - dividends (continued)

Franking credits

There were no franking credits available at the reporting date.

Note 22. Financial instruments

Financial risk management objectives

The consolidated entity’s activities expose it to a variety of financial risks: market risk, credit risk and liquidity risk. The consolidated entity uses different methods to measure and manage the different types of risks to which it is exposed. These methods include monitoring the levels of exposure to interest rates and foreign exchange, ageing analysis and monitoring of specific credit allowances to manage credit risk, and, rolling cash flow forecasts to manage liquidity risk.

Market risk

Foreign currency risk

The consolidated entity operates internationally and is exposed to foreign exchange risk arising from various currency exposures, primarily with respect to the US dollars (‘USD’). Foreign exchange risk arises from future transactions and recognised assets and liabilities denominated in a currency that is not the entity’s functional currency and net investments in foreign operations.

As of 30 June 2020, the consolidated entity did not hold derivative financial instruments in managing its foreign currency, however, the consolidated entity may from time to time enter into hedging arrangements where circumstances are deemed appropriate. The consolidated entity used natural hedging to reduce the foreign currency risk, which involved processing USD payments from cash held in USD. Foreign subsidiaries with a functional currency of Australian Dollars (‘AUD’) have exposure to the local currency of these subsidiaries and any other currency these subsidiaries trade in.

The carrying amount of the consolidated entity’s foreign currency denominated financial assets and financial liabilities at the reporting date was as follows:

|  | Assets |  |  | Liabilities |
|  | 2020 |  |  | 2019 |  |  | 2020 |  |  | 2019 |
|  | A$’000 |  |  | A$’000 |  |  | A$’000 |  |  | A$’000 |
US dollars |  |  | 272 |  |  |  | 31 |  |  |  | 2,196 |  |  |  | 1,046 |
Euros |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 1 |
|  |  | 272 |  |  |  | 31 |  |  |  | 2,196 |  |  |  | 1,047 |

The consolidated entity had net assets denominated in foreign currencies of A$2,448,320 as at 30 June 2020 (2019: net liabilities A$1,016,515).

F-25

##### Table of Contents

Notes to the financial statements

June 30, 2020

Note 22. Financial instruments (continued)

If the AUD had strengthened against the USD by 10% (2019: 10%) then this would have had the following impact:

|  | AUD strengthened |  |  | AUD weakened |
Consolidated - 2020 |  | % change |  |  | Effect on profit before tax A$’000 |  |  | Effect on equity A$’000 |  |  | % change |  |  | Effect on profit before tax A$’000 |  |  | Effect on equity A$’000 |
US dollars |  |  | 10 | % |  |  | 245 |  |  |  | 245 |  |  |  | (10 | %) |  |  | (245 | ) |  |  | (245 | )
|  |  |  |  |  |  | 245 |  |  |  | 245 |  |  |  |  |  |  |  | (245 | ) |  |  | (245 | )
|  | AUD strengthened |  |  | AUD weakened |
Consolidated - 2019 |  | % change |  |  | Effect on profit before tax A$’000 |  |  | Effect on equity A$’000 |  |  | % change |  |  | Effect on profit before tax A$’000 |  |  | Effect on equity A$’000 |
US dollars |  |  | 10 | % |  |  | 102 |  |  |  | 102 |  |  |  | (10 | %) |  |  | (102 | ) |  |  | (102 | )

Price risk

The consolidated entity is not exposed to any significant price risk.

Interest rate risk

The consolidated entity’s exposure to market interest rates relate primarily to the investments of cash balances.

The consolidated entity has cash reserves held primarily in Australian dollars and United States dollars and places funds on deposit with financial institutions for periods generally not exceeding three months.

As at the reporting date, the consolidated entity had the following variable interest rate balances:

|  | 2020 |  |  | 2019 |
|  | Weighted average interest rate % |  |  | Balance A$’000 |  |  | Weighted average interest rate % |  |  | Balance A$’000 |
Cash at bank and in hand |  |  | 0.04 | % |  |  | 1,264 |  |  |  | 0.03 | % |  |  | 834 |
Short term deposits |  |  | 0.95 | % |  |  | 7,500 |  |  |  | 1.88 | % |  |  | 4,600 |
Net exposure to cash flow interest rate risk |  |  |  |  |  |  | 8,764 |  |  |  |  |  |  |  | 5,434 |

The consolidated entity has cash and cash equivalents totalling $8,764,044 (2019: $5,433,868). An official increase/decrease in interest rates of 100 basis points (2019: 100 basis points) would have a favourable/adverse effect on profit before tax and equity of $87,640 (2019 $54,337) per annum. The percentage change is based on the expected volatility of interest rates using market data and analysts forecasts.

Credit risk

Credit risk refers to the risk that a counterparty will default on its contractual obligations resulting in financial loss to the consolidated entity. The entity is not exposed to significant credit risk on receivables.

The consolidated entity has adopted a lifetime expected loss allowance in estimating expected credit losses to trade receivables through the use of a provisions matrix using fixed rates of credit loss provisioning. These provisions are considered representative across all customers of the consolidated entity based on recent sales experience, historical collection rates and forward-looking information that is available.

The consolidated entity places its cash deposits with high credit quality financial institutions and by policy, limits the amount of credit exposure to any single counter-party. The consolidated entity is averse to principal loss and ensures the safety and preservation of its invested funds by limiting default risk, market risk, and reinvestment risk. The consolidated entity mitigates default risk by constantly positioning its portfolio to respond appropriately to a significant reduction in a credit rating of any financial institution.

Generally, trade receivables are written off when there is no reasonable expectation of recovery. Indicators of this include the failure of a debtor to engage in a repayment plan, no active enforcement activity and a failure to make contractual payments for a period greater than 1 year.

F-26

##### Table of Contents

Notes to the financial statements

June 30, 2020

Note 22. Financial instruments (continued)

There are no significant concentrations of credit risk within the consolidated entity. The credit risk on liquid funds is limited as the counter parties are banks with high credit ratings.

Credit risk is managed by limiting the amount of credit exposure to any single counter-party for cash deposits.

Liquidity risk

The consolidated entity manages liquidity risk by maintaining adequate cash reserves and by continuously monitoring actual and forecast cash flows and matching the maturity profiles of financial assets and liabilities. In particular, contingent consideration may be satisfied either by payment of cash or by issue of shares, at the discretion of the entity.

Remaining contractual maturities

The following tables detail the consolidated entity’s remaining contractual maturity for its financial instrument liabilities. The tables have been drawn up based on the undiscounted cash flows of financial liabilities based on the earliest date on which the financial liabilities are required to be paid. The tables include both interest and principal cash flows disclosed as remaining contractual maturities and therefore these totals may differ from their carrying amount in the statement of financial position.

2020 |  | Weighted average interest rate % |  |  | 1 year or less A$’000 |  |  | Between 1 and 2 years A$’000 |  |  | Between 2 and 5 years A$’000 |  |  | Over 5 years A$’000 |  |  | Remaining contractual maturities A$’000 |
Non-derivatives |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Non-interest bearing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Trade payables |  |  | — |  |  |  | 1,694 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 1,694 |
Accrued payables |  |  | — |  |  |  | 1,795 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 1,795 |
Contingent consideration |  |  | — |  |  |  | 4,199 |  |  |  | — |  |  |  | 2,644 |  |  |  | — |  |  |  | 6,843 |
Total non-derivatives |  |  |  |  |  |  | 7,688 |  |  |  | — |  |  |  | 2,644 |  |  |  | — |  |  |  | 10,332 |
2019 |  | Weighted average interest rate % |  |  | 1 year or less A$’000 |  |  | Between 1 and 2 years A$’000 |  |  | Between 2 and 5 years A$’000 |  |  | Over 5 years A$’000 |  |  | Remaining contractual maturities A$’000 |
Non-derivatives |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Non-interest bearing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Trade payables |  |  | — |  |  |  | 1,049 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 1,049 |
Accrued payables |  |  | — |  |  |  | 714 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 714 |
Contingent consideration |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 5,194 |  |  |  | 1,394 |  |  |  | 6,588 |
Total non-derivatives |  |  |  |  |  |  | 1,763 |  |  |  | — |  |  |  | 5,194 |  |  |  | 1,394 |  |  |  | 8,351 |

The cash flows in the maturity analysis above are not expected to occur significantly earlier than contractually disclosed above.

Note 23. Fair value measurement

Fair value hierarchy

The following tables detail the consolidated entity’s assets and liabilities, measured or disclosed at fair value, using a three level hierarchy, based on the lowest level of input that is significant to the entire fair value measurement, being:

Level 1: Quoted prices (unadjusted) in active markets for identical assets or liabilities that the entity can access at the measurement date

Level 2: Inputs other than quoted prices included within Level 1 that are observable for the asset or liability, either directly or indirectly

F-27

##### Table of Contents

Notes to the financial statements

June 30, 2020

Note 23. Fair value measurement (continued)

Level 3: Unobservable inputs for the asset or liability

Consolidated - 2020 |  | Level 1 A$’000 |  |  | Level 2 A$’000 |  |  | Level 3 A$’000 |  |  | Total A$’000 |
Liabilities |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contingent Consideration |  |  | — |  |  |  | — |  |  |  | 1,845 |  |  |  | 1,845 |
Total liabilities |  |  | — |  |  |  | — |  |  |  | 1,845 |  |  |  | 1,845 |
Consolidated - 2019 |  | Level 1 A$’000 |  |  | Level 2 A$’000 |  |  | Level 3 A$’000 |  |  | Total A$’000 |
Assets |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ordinary shares - listed |  |  | 25 |  |  |  | — |  |  |  | — |  |  |  | 25 |
Contingent Consideration |  |  | — |  |  |  | — |  |  |  | 143 |  |  |  | 143 |
Total Assets |  |  | 25 |  |  |  | — |  |  |  | 143 |  |  |  | 168 |
Liabilities |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contingent Consideration |  |  | — |  |  |  | — |  |  |  | 1,370 |  |  |  | 1,370 |
Total liabilities |  |  | — |  |  |  | — |  |  |  | 1,370 |  |  |  | 1,370 |

There were no transfers between levels during the financial year.

The fair value of contingent consideration related to the acquisition of Glioblast Pty Ltd and the licence agreement is estimated by probability-weighting the expected future cash outflows, adjusting for risk and discounting.

The effects on the fair value of risk and uncertainty in the future cash flows are dealt with by adjusting the estimated cash flows rather than adjusting the discount rate. The estimated cashflows were adjusted based on the directors’ assessment of achieving contracted milestones as disclosed in Note 19. The probabilities used fell in the range of 35% to 55% and were informed by generally accepted industry probabilities of drugs achieving certain milestones in their progression towards registration.

Note 24. Key management personnel disclosures

Compensation

The aggregate compensation made to directors and other members of key management personnel (‘KMP’) of the consolidated entity is set out below:

|  | 2020 A$’000 |  |  | 2019 A$’000 |  |  | 2018 A$’000 |
Short-term employee benefits |  |  | 1,324 |  |  |  | 1,176 |  |  |  | 1,636 |
Post-employment benefits |  |  | 97 |  |  |  | 84 |  |  |  | 90 |
Share-based payments |  |  | 230 |  |  |  | 125 |  |  |  | 117 |
|  |  | 1,651 |  |  |  | 1,385 |  |  |  | 1,843 |

Please refer to Note 28 for other transactions with key management personnel and their related parties.

Note 25. Remuneration of auditors

During the financial year the following fees were paid or payable for services provided by Grant Thornton Audit Pty Ltd, the auditor of the consolidated entity:

|  | Consolidated |
|  | 2020 A$’000 |  |  | 2019 A$’000 |  |  | 2018 A$’000 |
Audit services - Grant Thornton Audit Pty Ltd |  |  |  |  |  |  |  |  |  |  |  |
Audit or review of the financial statements |  |  | 124 |  |  |  | 120 |  |  |  | 131 |
F3 consent |  |  | — |  |  |  | — |  |  |  | 11 |
|  |  | 124 |  |  |  | 120 |  |  |  | 142 |

F-28

##### Table of Contents

Notes to the financial statements

June 30, 2020

Note 26. Contingent liabilities

The consolidated entity is continuing to prosecute its Intellectual Property (‘IP’) rights against an Austrian company, APOtrend. At 30 June 2018 the Austrian Supreme Court has rendered a final decision on the patent infringement. As a result, Kazia is entitled to make a claim against APOtrend in relation to two of the three products which were the subject of the claim, while for the third product, Kazia’s claim was denied. In respect of this third product, APOtrend is entitled to claim compensation for damages caused by a preliminary injunction. At the date of this report, no claim has been made by either party. Kazia is entitled to access APOtrend’s books to calculate a license fee/other payment claims against APOtrend. Kazia is currently trying to enforce this right in court.

The consolidated entity has provided a guarantee to the value of €250,000 (A$409,098) with the court to provide a security for potential damage claims raised by APOtrend (which is not limited to this amount, however). As at 30 June 2020, the receivable balance continues to be fully impaired on the basis that it is unlikely to be recovered.

Note 27. Commitments

Lease commitments comprise contracted amounts for leases of premises. The agreement has a duration less than 12 months from financial year end and committed amounts are not material.

Note 28. Related party transactions

Parent entity

Kazia Therapeutics Limited is the parent entity.

Subsidiaries

Interests in subsidiaries are set out in note 30.

Key management personnel

Disclosures relating to key management personnel are set out in note 24 and the remuneration report included in the directors’ report.

Transactions with related parties

There was no other transaction with KMP and their related parties.

F-29

##### Table of Contents

Notes to the financial statements

June 30, 2020

Note 28. Related party transactions (continued)

Receivable from and payable to related parties

There were no trade receivables from or trade payables to related parties at the current and previous reporting date.

Loans to/from related parties

There were no loans to or from related parties at the current and previous reporting date.

Terms and conditions

All transactions were made on normal commercial terms and conditions and at market rates.

Contingent liabilities

The parent entity had no contingent liabilities as at 30 June 2020 and 30 June 2019, except as detailed in note 26.

Capital commitments - Property, plant and equipment

The parent entity had no capital commitments for property, plant and equipment at as 30 June 2020 and 30 June 2019.

Significant accounting policies

The accounting policies of the parent entity are consistent with those of the consolidated entity, as disclosed in note 2, except for the following:

• |  | Investments in subsidiaries are accounted for at cost, less any impairment, in the parent entity.

• |  | Dividends received from subsidiaries are recognised as other income by the parent entity and its receipt may be an indicator of an impairment of the investment.

Note 29. Parent entity information

Set out below is the supplementary information about the parent entity.

|  | Parent |
|  | 2020 A$’000 |  |  | 2019 A$’000 |
Statement of profit or loss and other comprehensive income |  |  |  |  |  |  |  |
Loss after income tax |  |  | (11,064 | ) |  |  | (7,198 | )
Total comprehensive income |  |  | (11,064 | ) |  |  | (7,198 | )
|  | 2020 A$’000 |  |  | 2019 A$’000 |
Statement of financial position |  |  |  |  |  |  |  |
Total current assets |  |  | 9,703 |  |  |  | 7,015 |
Total assets |  |  | 22,113 |  |  |  | 20,677 |
Total current liabilities |  |  | 1,522 |  |  |  | 213 |
Total liabilities |  |  | 5,393 |  |  |  | 5,295 |
Equity |  |  |  |  |  |  |  |
Contributed equity |  |  | 48,781 |  |  |  | 36,641 |
Other contributed equity |  |  | 464 |  |  |  | 464 |
Reserves |  |  | 1,521 |  |  |  | 2,489 |
Accumulated losses |  |  | (34,046 | ) |  |  | (24,212 | )
Total equity |  |  | 16,720 |  |  |  | 15,382 |

F-30

##### Table of Contents

Notes to the financial statements

June 30, 2020

Note 30. Interests in subsidiaries

The consolidated financial statements incorporate the assets, liabilities and results of the following subsidiaries in accordance with the accounting policy described in note 2:

|  |  |  | Ownership interest |
Name |  | Principal place of business / Country of incorporation |  | 2020 % |  |  | 2019 % |
Kazia Laboratories Pty Ltd |  | Australia |  |  | 100.00 | % |  |  | 100.00 | %
Kazia Research Pty Ltd |  | Australia |  |  | 100.00 | % |  |  | 100.00 | %
Kazia Therapeutics Inc. |  | United States of America |  |  | 100.00 | % |  |  | 100.00 | %
Glioblast Pty Ltd |  | Australia |  |  | 100.00 | % |  |  | 100.00 | %

Note 31. Reconciliation of loss after income tax to net cash used in operating activities

|  | 2020 |  |  | 2019 |  |  | 2018 |
|  | A$’000 |  |  | A$’000 |  |  | A$’000 |
Loss after income tax expense from continuing operations |  |  | (12,467 | ) |  |  | (10,270 | ) |  |  | (6,039 | )
Adjustments for: |  |  |  |  |  |  |  |  |  |  |  |
Depreciation & amortisation |  |  | 1,084 |  |  |  | 1,084 |  |  |  | 1,547 |
Impairment of property, plant & equipment |  |  | — |  |  |  | 1 |  |  |  | 143 |
Net loss on disposal on disposal of non-current assets |  |  | — |  |  |  | — |  |  |  | 136 |
Net fair value loss on financial assets |  |  | 168 |  |  |  | 1,809 |  |  |  | 3,944 |
Share based payments |  |  | 262 |  |  |  | 246 |  |  |  | 165 |
Shares issued for no consideration |  |  | — |  |  |  | — |  |  |  | 30 |
Foreign exchange differences |  |  | — |  |  |  | — |  |  |  | (251 | )
Gain on legal settlement |  |  | — |  |  |  | — |  |  |  | (8,411 | )
Loss on contingent consideration |  |  | 474 |  |  |  | 63 |  |  |  | (1,461 | )
Change in operating assets & liabilities: |  |  | (10,479 | ) |  |  | (7,067 | ) |  |  | (10,197 | )
Decrease in trade and other receivables |  |  | 358 |  |  |  | 825 |  |  |  | 1,724 |
Increase in accrued revenue |  |  | — |  |  |  | (138 | ) |  |  | 97 |
Decrease/(increase) in prepayments |  |  | (168 | ) |  |  | 398 |  |  |  | (10 | )
Decrease/(increase) in trade and other payables |  |  | 1,721 |  |  |  | (409 | ) |  |  | 88 |
Decrease in deferred tax liability |  |  | (298 | ) |  |  | (298 | ) |  |  | (305 | )
Increase/(decrease) in other provisions |  |  | 55 |  |  |  | (25 | ) |  |  | (58 | )
Net cash used in operating activities |  |  | (8,811 | ) |  |  | (6,714 | ) |  |  | (8,661 | )

Note 32. Earnings per share

|  | 2020 A$’000 |  |  | 2019 A$’000 |  |  | 2018 A$’000 |
Loss after income tax attributable to the owners of Kazia Therapeutics Limited |  |  | (12,467 | ) |  |  | (10,270 | ) |  |  | (6,039 | )
Loss after income tax attributable to the owners of Kazia Therapeutics Limited |  |  | (12,467 | ) |  |  | (10,270 | ) |  |  | (6,039 | )
|  | Number |  |  | Number |  |  | Number |
Weighted average number of ordinary shares used in calculating basic earnings per share |  |  | 73,053,514 |  |  |  | 57,503,555 |  |  |  | 48,376,525 |
Weighted average number of ordinary shares used in calculating Diluted earnings per share |  |  | 73,053,514 |  |  |  | 57,503,555 |  |  |  | 48,376,525 |
|  | Cents |  |  | Cents |  |  | Cents |
Basic earnings per share |  |  | (17.07 | ) |  |  | (17.86 | ) |  |  | (12.48 | )
Diluted earnings per share |  |  | (17.07 | ) |  |  | (17.86 | ) |  |  | (12.48 | )

1,865,000 unlisted convertible notes with a face value of A$464,000 and 2,775,167 unlisted options have been excluded from the above calculations as they were antidilutive.

Note 33. Share-based payments

The options in the first three tranches in the table below were issued as consideration for services rendered in relation to capital raising conducted during a previous year by the consolidated entity, and have now expired.

The options in the remaining tranches in the table below have been issued to employees under the ESOP. In total, $262,105 (2019: $246,387) of employee remuneration expense (all of which related to equity-settled share-based payment transactions) has been included in profit or loss during the year and credited to share-based payment reserve.

F-31

##### Table of Contents

Notes to the financial statements

June 30, 2020

Note 33. Share-based payments (continued)

Options in tranches 5-7 and 15 represent a modification which occurred during the year. The options in tranches 5-7 were cancelled and the options in tranche 15 issued in their stead. These options were issued to the CEO and Managing Director, and the modification was approved by the shareholders on 13 November 2019. The option pricing model used to determine the incremental fair value was a Black-Scholes option pricing model. The inputs into the valuation model are set out in a table later in this note and the assumptions with regard to dividends, volatility and risk-free rate are relevant to the newly issued replacement options. The volatility was determined based upon historical volatility. The fair value of the new options granted was $216,000 and the fair value of the old options was de minimus just prior to the modification. Therefore, the incremental fair value of the modification was $216,000.

The terms of the options were agreed by the directors on 4 January 2019, including immediate vesting of 50% of the options, with the remaining options to vest in equal portions over the following three years starting 4 January 2020. The options will expire on 4 January 2024. Because the options required shareholder approval they were not issued until that approval was granted on 13 November 2019, however the terms were as agreed on 4 January 2019.

2020

Tranche |  | Grant date |  |  | Expiry date |  |  | A$ Exercise price |  |  | Balance at the start of the year |  |  | Granted |  |  | Modified |  |  | Expired |  |  | Balance at the end of the year |
1 |  |  | 04/03/2015 |  |  |  | 16/12/2019 |  |  | $ | 1.500 |  |  |  | 46,647 |  |  |  | — |  |  |  | — |  |  |  | (46,647 | ) |  |  | — |
2 |  |  | 04/03/2015 |  |  |  | 18/12/2019 |  |  | $ | 1.500 |  |  |  | 19,952 |  |  |  | — |  |  |  | — |  |  |  | (19,952 | ) |  |  | — |
3 |  |  | 24/06/2015 |  |  |  | 30/06/2020 |  |  | $ | 4.000 |  |  |  | 519,000 |  |  |  | — |  |  |  | — |  |  |  | (519,000 | ) |  |  | — |
4 |  |  | 16/11/2015 |  |  |  | 16/11/2020 |  |  | $ | 2.200 |  |  |  | 236,667 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 236,667 |
5 |  |  | 18/03/2016 |  |  |  | 01/02/2021 |  |  | $ | 1.990 |  |  |  | 300,000 |  |  |  | — |  |  |  | (300,000 | ) |  |  | — |  |  |  | — |
6 |  |  | 18/03/2016 |  |  |  | 01/02/2021 |  |  | $ | 1.990 |  |  |  | 200,000 |  |  |  | — |  |  |  | (200,000 | ) |  |  | — |  |  |  | — |
7 |  |  | 18/03/2016 |  |  |  | 01/02/2021 |  |  | $ | 2.610 |  |  |  | 250,000 |  |  |  | — |  |  |  | (250,000 | ) |  |  | — |  |  |  | — |
8 |  |  | 05/09/2016 |  |  |  | 05/09/2021 |  |  | $ | 1.630 |  |  |  | 50,000 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 50,000 |
9 |  |  | 12/10/2016 |  |  |  | 17/10/2021 |  |  | $ | 1.560 |  |  |  | 62,000 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 62,000 |
10 |  |  | 31/10/2016 |  |  |  | 01/11/2021 |  |  | $ | 1.380 |  |  |  | 12,500 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 12,500 |
11 |  |  | 21/11/2016 |  |  |  | 23/11/2021 |  |  | $ | 1.380 |  |  |  | 50,000 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 50,000 |
12 |  |  | 07/08/2017 |  |  |  | 07/08/2022 |  |  | $ | 0.670 |  |  |  | 224,000 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 224,000 |
13 |  |  | 05/02/2018 |  |  |  | 05/02/2023 |  |  | $ | 0.780 |  |  |  | 440,000 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 440,000 |
14 |  |  | 04/01/2019 |  |  |  | 04/01/2024 |  |  | $ | 0.492 |  |  |  | 250,000 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 250,000 |
15 |  |  | 13/11/2019 |  |  |  | 04/01/2024 |  |  | $ | 0.492 |  |  |  | — |  |  |  | — |  |  |  | 1,200,000 |  |  |  | — |  |  |  | 1,200,000 |
16 |  |  | 13/01/2020 |  |  |  | 13/01/2025 |  |  | $ | 0.881 |  |  |  | — |  |  |  | 250,000 |  |  |  | — |  |  |  | — |  |  |  | 250,000 |
|  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,660,766 |  |  |  | 250,000 |  |  |  | 450,000 |  |  |  | (585,599 | ) |  |  | 2,775,167 |
Weighted average exercise price |  |  |  |  |  |  | $ | 1.960 |  |  | $ | 0.880 |  |  | $ | 2.348 |  |  | $ | 3.716 |  |  | $ | 0.797 |

No options were exercised or forfeited during the year.

At the end of the period the following outstanding options were vested and exercisable:

- Options in tranches 4, 8, 10, 11 and 13 were vested and exercisable

- Options in tranche 16 were unvested

- Options in the other tranches were vested as follows: 9: 75%, 12: 50% 14: 50% and 15: 67%. All were able to be exercised at year end.

All remaining options are expected to vest in future periods.

The weighted average remaining contractual life of options outstanding at the 30 June 2020 is 2.78 years.

F-32

##### Table of Contents

Notes to the financial statements

June 30, 2020

Note 33. Share-based payments (continued)

2019

Tranche |  | Grant date |  |  | Expiry date |  |  | A$ Exercise price |  |  | Balance at the start of the year |  |  | Granted |  |  | Exercised |  |  | Forfeited on cessation of employment |  |  | Balance at the end of the year |
1 |  |  | 04/03/2015 |  |  |  | 16/12/2019 |  |  | $ | 1.500 |  |  |  | 46,647 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 46,647 |
2 |  |  | 04/03/2015 |  |  |  | 18/12/2019 |  |  | $ | 1.500 |  |  |  | 19,952 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 19,952 |
3 |  |  | 24/06/2015 |  |  |  | 30/06/2020 |  |  | $ | 4.000 |  |  |  | 519,000 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 519,000 |
4 |  |  | 16/11/2015 |  |  |  | 16/11/2020 |  |  | $ | 2.200 |  |  |  | 236,667 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 236,667 |
5 |  |  | 18/03/2016 |  |  |  | 01/02/2021 |  |  | $ | 1.990 |  |  |  | 300,000 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 300,000 |
6 |  |  | 18/03/2016 |  |  |  | 01/02/2021 |  |  | $ | 1.990 |  |  |  | 200,000 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 200,000 |
7 |  |  | 18/03/2016 |  |  |  | 01/02/2021 |  |  | $ | 2.610 |  |  |  | 250,000 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 250,000 |
8 |  |  | 05/09/2016 |  |  |  | 05/09/2021 |  |  | $ | 1.630 |  |  |  | 50,000 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 50,000 |
9 |  |  | 12/10/2016 |  |  |  | 17/10/2021 |  |  | $ | 1.560 |  |  |  | 62,000 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 62,000 |
10 |  |  | 31/10/2016 |  |  |  | 01/11/2021 |  |  | $ | 1.380 |  |  |  | 12,500 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 12,500 |
11 |  |  | 21/11/2016 |  |  |  | 23/11/2021 |  |  | $ | 1.380 |  |  |  | 50,000 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 50,000 |
12 |  |  | 07/08/2017 |  |  |  | 07/08/2022 |  |  | $ | 0.670 |  |  |  | 224,000 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 224,000 |
13 |  |  | 05/02/2018 |  |  |  | 05/02/2023 |  |  | $ | 0.780 |  |  |  | 440,000 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 440,000 |
14 |  |  | 04/01/2019 |  |  |  | 04/01/2024 |  |  | $ | 0.492 |  |  |  | — |  |  |  | 250,000 |  |  |  | — |  |  |  | — |  |  |  | 250,000 |
|  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,410,766 |  |  |  | 250,000 |  |  |  | — |  |  |  | — |  |  |  | 2,660,766 |
Weighted average exercise price |  |  |  |  |  |  | A$ | 2.120 |  |  | A$ | 0.490 |  |  | A$ | 0.000 |  |  | A$ | 0.000 |  |  | A$ | 1.960 |

At the end of the period the following options were vested and exercisable:

- Options from Tranche 1 to Tranche 6, Tranches 8, 10 and 11 were vested and exercisable

- Options in Tranches 7 and 14 were unvested

- Options from Tranche 9 and 13 were vested and exercisable as to 50%

- Options from Tranche 12 were vested and exercisable as to 25%

All remaining options are expected to vest in future periods. No options have expired during the financial year.

The weighted average remaining contractual life of options outstanding at the 30 June 2019 is 1.43 years.

Employee share options

During the year ended 30 June 2020, 250,000 options have been issued to the employees by the consolidated entity pursuant to the Company’s Employee Share Option Plan.

• |  | Tranche 16 of 250,000 options vesting equally over 4 years in annual intervals from 13 January 2021.

Also during the year, 750,000 options were cancelled and replaced by 1,200,000 new options issued in their place. This has been accounted for as a modification of the first series of options, as their cancellation was contingent upon receipt of shareholder approval for the issue of the new options.

Of the new options, which are shown as tranche 15:

• |  | 50% vested immediately

• |  | the remaining 50% vest equally over 3 years in annual intervals from 4 January 2020

An option will only vest if the option holder continues to be a full-time employee with the Company or an Associated Company during the vesting period relating to the option.

Conditions for an option to be exercised:

• |  | The option must have vested and a period of 1 year from the date the option was issued must have expired;

• |  | Option holder must have provided the Company with an Exercise Notice and have paid the Exercise Price for the option.

• |  | The Exercise Notice must be for the exercise of at least the Minimum Number of Options;

F-33

##### Table of Contents

Notes to the financial statements

June 30, 2020

Note 33. Share-based payments (continued)

• |  | The Exercise Notice must have been provided to the Company and Exercise Price paid before the expiry of 5 years from the date the Option is issued.

Options Valuation

In order to obtain a fair valuation of these options, the following assumptions have been made:

The Black Scholes option valuation methodology has been used with the expectation that the majority of these options would be exercised towards the end of the option term. Inputs into the Black Scholes model includes the share price at grant date, exercise price, volatility, and the risk free rate of a five year Australian Government Bond on grant date.

Risk-free rate and grant date

For all tranches, the risk-free rate of a five-year Australian Government bond on grant date was used. Please refer to the table below for details.

Options in Tranches 1 to 16 have various vesting periods and exercising conditions. These options are unlisted as at 30 June 2020.

No dividends are expected to be declared or paid by the consolidated entity during the terms of the options.

The underlying expected volatility was determined by reference to historical data of the Company’s shares over a period of time. No special features inherent to the options granted were incorporated into measurement of fair value.

Based on the above assumptions, the table below sets out the valuation for each tranche of options:

Grant date |  | Expiry date |  | Share price at Grant Date |  | Exercise price |  | Volatility (%) |  | Remaining Life (years) |  | Risk free Rate (%) |  | Fair value per option
16/11/2015 |  | 16/11/2020 |  | $0.140 |  | $2.200 |  | 158.00% |  | 0.37 |  | 2.04% |  | $1.280
05/09/2016 |  | 05/09/2021 |  | $0.105 |  | $1.630 |  | 122.00% |  | 1.16 |  | 1.60% |  | $0.840
12/10/2016 |  | 17/10/2021 |  | $0.098 |  | $1.560 |  | 122.00% |  | 1.29 |  | 1.89% |  | $0.780
31/10/2016 |  | 01/11/2021 |  | $0.090 |  | $1.380 |  | 122.00% |  | 1.20 |  | 1.87% |  | $0.720
21/11/2016 |  | 23/11/2021 |  | $0.092 |  | $1.380 |  | 122.00% |  | 1.20 |  | 2.10% |  | $0.730
07/08/2017 |  | 07/08/2022 |  | $0.430 |  | $0.670 |  | 74.50% |  | 2.08 |  | 1.95% |  | $0.206
05/02/2018 |  | 05/02/2023 |  | $0.500 |  | $0.780 |  | 74.50% |  | 2.58 |  | 1.95% |  | $0.200
04/01/2019 |  | 04/01/2024 |  | $0.340 |  | $0.493 |  | 74.50% |  | 3.50 |  | 1.95% |  | $0.140
13/11/2019 |  | 13/11/2024 |  | $0.410 |  | $0.493 |  | 74.50% |  | 4.20 |  | 1.95% |  | $0.180
13/01/2020 |  | 13/01/2025 |  | $0.620 |  | $0.881 |  | 74.50% |  | 4.50 |  | 1.95% |  | $0.340

F-34

##### Table of Contents

Notes to the financial statements

June 30, 2020

Note 34. Subsequent events

In August 2020 the Company was advised that the United States Food and Drug Administration (FDA) has awarded Rare Pediatric Disease Designation (RPDD) to Kazia’s paxalisib (formerly GDC-0084) for the treatment of Diffuse Intrinsic Pontine Glioma (DIPG), a rare and highly-aggressive childhood brain cancer.

In August 2020 the Company was also advised that the FDA has awarded Fast Track Designation (FTD) to paxalisib for the treatment of glioblastoma, the most common and the most aggressive form of primary brain cancer in adults.

In August 2020 United States Food and Drug Administration (FDA) has granted Orphan Drug Designation (ODD) to Kazia’s paxalisib (formerly GDC-0084) for the treatment of malignant glioma, which includes Diffuse Intrinsic Pontine Glioma (DIPG), a rare and highly aggressive childhood brain cancer.

In October 2020 the Company raised approximately $24 million (after costs) from a fully underwritten entitlement offer to eligible shareholders. The proceeds of the offer will be used to fund the Company’s participation in the GBM Agile study for paxalisib in glioblastoma (GBM Agile) and for general working capital.

F-35