##### Table of Contents

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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM
20-F
(Mark One)

☐ | REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934

OR

☒ | ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the fiscal year ended June 30, 2024
OR

☐ | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

OR

☐ | SHELL COMPANY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

Date of event requiring this shell company report
For the transition period from
to
Commission file number
0-29962
Kazia Therapeutics Limited
ACN 063 259 754
(Exact name of Registrant as specified in its charter)
Not Applicable
(Translation of Registrant’s name into English)
New South Wales, Australia
(Jurisdiction of incorporation or organization)
Three International Towers, Level 24, 300 Barangaroo Avenue, Sydney, New South Wales 2000, Australia
(Address of principal executive offices)
John Friend, M.D.
(e)John.Friend@kaziatherapeutics.com (t)
+61-2-9472-4101
Three International Towers, Level 24, 300 Barangaroo Avenue, Sydney, New South Wales 2000, Australia
(Name, Telephone,
E-mail
and/or Facsimile number and Address of Company Contact Person)
Securities registered or to be registered pursuant to Section 12(b) of the Act.

Title of each class |  | Trading Symbol(s) |  | Name of each exchange on which registered
American Depositary Shares, each representing one-hundred Ordinary Shares* |  | KZIA |  | The Nasdaq Stock Market

Securities registered or to be registered pursuant to Section 12(g) of the Act.
None

* | Not for trading, but only in connection with the registration of American Depositary Shares.

Securities for which there is a reporting obligation pursuant to Section 15(d) of the Act.
Not Applicable
Indicate the number of outstanding shares of each of the issuer’s classes of capital or common stock as of the close of the period covered by the annual report.
The number of outstanding Ordinary Shares of the issuer as at 30 June 2024, was
332,850,784.
Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act.
Yes ☐No☒
If this report is an annual or transition report, indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934.
Yes ☐No☒
Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.
Yes☒    No ☐
Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation
S-T
(§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files).
Yes☒    No ☐
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a
non-accelerated
filer, or an emerging growth company. See definition of “large accelerated filer”, “accelerated filer”, and “emerging growth company” in Rule
12b-2
of the Exchange Act:
Large accelerated filer ☐    Accelerated
filer ☐
Non-accelerated
filer☒    Emerging growth company☐
If an emerging growth company that prepares its financial statements in accordance with U.S. GAAP, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐
Indicate by check mark whether the registrant has filed a report on and attestation to its management’s assessment of the effectiveness of its internal control over financial reporting under Section 404(b) of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) by the registered public accounting firm that prepared or issued its audit report.☐
If securities are registered pursuant to Section 12(b) of the Act, indicate by check mark whether the financial statements of the registrant included in the filing reflect the correction of an error to previously issued financial statements.☐
Indicate by check mark whether any of those error corrections are restatements that required a recovery analysis of incentive-based compensation received by any of the registrant’s executive officers during the relevant recovery period pursuant to
§240.10D-1(b). ☐
Indicate by check mark which basis of accounting the registrant has used to prepare the financial statements included in this filing:

U.S. GAAP ☐ |  | International Financial Reporting Standards as issued by the International Accounting Standards Board ☒ |  |  | Other | ☐

If ‘Other’ has been checked in response to the previous question, indicate by check mark which financial statement item the registrant has elected to follow.
Item 17 ☐    Item 18 ☐
If this is an annual report, indicate by check mark whether the registrant is a shell company (as defined in Rule
12b-2
of the Exchange Act).
Yes ☐    No☒

##### Table of Contents

FORWARD-LOOKING STATEMENTS |  |  | 1 |
PART I |  |  |  |  | 1 |
Item 1. |  | Identity of Directors, Senior Management and Advisors |  |  | 1 |
Item 2. |  | Offer Statistics and Expected Timetable |  |  | 1 |
Item 3. |  | Key Information |  |  | 1 |
Item 4. |  | Information on the Company |  |  | 16 |
Item 4A. |  | Unresolved Staff Comments |  |  | 31 |
Item 5. |  | Operating and Financial Review and Prospects |  |  | 31 |
Item 6. |  | Directors, Senior Management and Employees |  |  | 36 |
Item 7. |  | Major Shareholders and Related Party Transactions |  |  | 48 |
Item 8. |  | Financial Information |  |  | 49 |
Item 9. |  | The Offer and Listing |  |  | 49 |
Item 10. |  | Additional Information |  |  | 49 |
Item 11. |  | Quantitative and Qualitative Disclosures about Market Risk |  |  | 62 |
Item 12. |  | Description of Securities Other than Equity Securities |  |  | 63 |
PART II |  |  | 64 |
Item 13. |  | Defaults, Dividend Arrearages and Delinquencies |  |  | 64 |
Item 14. |  | Material Modifications to the Rights of Security Holders and the Use of Proceeds |  |  | 64 |
Item 15. |  | Controls and Procedures |  |  | 65 |
Item 16. |  | [Reserved] |  |  | 65 |
Item 16A. |  | Audit Committee Financial Expert |  |  | 65 |
Item 16B. |  | Code of Ethics |  |  | 66 |
Item 16C. |  | Principal Accounting Fees and Services |  |  | 66 |
Item 16D. |  | Exemptions from the Listing Standards for Audit Committees |  |  | 67 |
Item 16E. |  | Purchases of Equity Securities by the Issuer and Affiliated Purchasers |  |  | 67 |
Item 16F. |  | Changes in Registrant’s Certifying Accountant |  |  | 67 |
Item 16G. |  | Corporate Governance |  |  | 67 |
Item 16H. |  | Mine Safety Disclosure |  |  | 68 |
Item 16I. |  | Disclosure Regarding Foreign Jurisdictions that Prevent Inspections |  |  | 68 |
Item 16J. |  | Insider trading policies |  |  | 68 |
Item 16K. |  | Cybersecurity |  |  | 69 |
PART III |  |  | 69 |
Item 17. |  | Financial Statements |  |  | 69 |
Item 18. |  | Financial Statements |  |  | 69 |
Item 19. |  | Exhibits |  |  | 70 |

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FORWARD-LOOKING STATEMENTS

This Annual Report on Form 20-F includes forward-looking statements, which involve a number of risks and uncertainties. These forward-looking statements can generally be identified as such because the context of the statement will include words such as “may,” “will,” “intend,” “plan,” “believe,” “anticipate,” “expect,” “estimate,” “predict,” “potential,” “continue,” “likely,” or “opportunity,” the negative of these words or other similar words. Similarly, statements that describe our future plans, strategies, intentions, expectations, objectives, goals or prospects and other statements that are not historical facts are also forward-looking statements. Discussions containing these forward-looking statements may be found, among other places, in “Business Overview” and “Operating and Financial Review and Prospects” in this Annual Report on Form 20-F. For such statements, we claim the protection of the Private Securities Litigation Reform Act of 1995 and section 27A of the Securities Act and Section 21E of the Exchange Act. Readers of this Annual Report on Form 20-F are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the time this Annual Report on Form 20-F was filed with the Securities and Exchange Commission, or SEC. These forward-looking statements are based largely on our expectations and projections about future events and future trends affecting our business and are subject to risks and uncertainties that could cause actual results to differ materially from those anticipated in the forward-looking statements. These risks and uncertainties include, without limitation, those discussed in “Risk Factors” and in “Operating and Financial Review and Prospects” of this Annual Report on Form 20-F. In addition, past financial or operating performance is not necessarily a reliable indicator of future performance, and you should not use our historical performance to anticipate results or future period trends. We can give no assurances that any of the events anticipated by the forward-looking statements will occur or, if any of them do, what impact they will have on our results of operations and financial condition. Except as required by law, we undertake no obligation to update publicly or revise our forward-looking statements to reflect events or circumstances that arise after the filing of this Annual Report on Form 20-F.

In this Annual Report on Form 20-F, “Kazia,” “Company,” “we,” “us” and “our” refer to Kazia Therapeutics Limited and its wholly owned subsidiaries on a consolidated basis, unless the context otherwise provides.

PART I

Item 1. | Identity of Directors, Senior Management and Advisors

Item 1 details are not required to be disclosed as part of the Annual Report.

Item 2. | Offer Statistics and Expected Timetable

Item 2 details are not required to be disclosed as part of the Annual Report.

Item 3. | Key Information

A. Reserved

B. Capitalization and Indebtedness.

Not applicable.

C. Reasons for the Offer and Use of Proceeds.

Not applicable.

D. Risk factors

Investment in our securities involves a high degree of risk. You should consider carefully the risks described below, together with other information in this Annual Report on Form 20-F and our other public filings, before making investment decisions regarding our securities. If any of the following events actually occur, our business, operating results, prospects or financial condition could be materially and adversely affected. This could cause the trading price of our common stock to decline and you may lose all or part of your investment. Moreover, the risks described below are not the only ones that we face. Additional risks not presently known to us or that we currently deem immaterial may also affect our business, operating results, prospects or financial condition.

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Risks Related to Our Financial Condition and Capital Requirement

We have incurred significant net losses since our inception. We expect to incur significant net losses for the foreseeable future and may never achieve or maintain profitability.

We have incurred significant net losses. We anticipate that we will continue to incur significant net losses for the foreseeable future and we may never achieve or maintain profitability. We are a biotechnology company and have not yet generated significant revenue. We have incurred losses of A$25.0 million, A$20.5 million, and A$26.8 million for the fiscal years ended 30 June 2022 (restated), 2023, and 2024, respectively. We generated revenues of A$2.3 million during 2024 from the licensing of our development stage drug candidates. We did not generate any revenues from sales of any of our product candidates in prior financial years.

As of 30 June 2024, we had accumulated losses of A$115.1 million. We have devoted most of our financial resources to research and development, including our clinical development activities. To date, we have financed our operations primarily through the issuance of equity securities, research and development grants from the Australian government and payments from our collaboration partners. While we have generated significant revenue in recent fiscal years from license transactions, the nature of such revenue is irregular and unpredictable, and is based upon achievement of milestones over which we have limited or no control. As a consequence, we expect to continue to incur significant operating losses for the foreseeable future due to the cost of research and development including clinical trials and the regulatory approval process for product candidates. The amount of our future net losses is uncertain and will depend, in part, on the rate of our future expenditures. Our ability to continue operations will depend on, among other things, our ability to obtain funding through equity or debt financings, strategic collaborations or grants.

We anticipate that our expenses will increase substantially if and as we:

| • |  | continue our research and clinical development of our product candidates;

| • |  | expand the scope of our current clinical studies for our product candidates or initiate additional clinical or other studies for product candidates;

| • |  | seek regulatory and marketing approvals for any of our product candidates that successfully complete clinical trials;

| • |  | further develop the manufacturing process for our product candidates;

| • |  | change or add additional manufacturers or suppliers;

| • |  | seek to identify and validate additional product candidates;

| • |  | acquire or in-license other product candidates and technologies;

| • |  | maintain, protect and expand our intellectual property portfolio;

| • |  | create additional infrastructure to support our operations as a public company in the United States and our product development and future commercialization efforts; and

| • |  | experience any delays or encounter issues with any of the above.

The net losses we incur may fluctuate significantly from year to year, such that a period-to-period comparison of our results of operations may not be a good indication of our future performance.

We have a history of operating losses and we expect to continue to incur losses and may never be profitable.

Our ability to generate significant revenue and achieve profitability depends on our ability, alone or with strategic collaboration partners, to successfully complete the development of and obtain the regulatory approvals for our product candidates, to manufacture sufficient supply of our product candidates, to establish a sales and marketing organization or suitable third-party alternative for the marketing of any approved products and to successfully commercialize any approved products on commercially reasonable terms. All of these activities will require us to raise sufficient funds to finance business activities. In addition, we do not anticipate generating revenue from commercializing product candidates for the foreseeable future, if ever. Our ability to generate future revenues from commercializing product candidates depends heavily on:

| • |  | successfully initiating and completing clinical trials of our product candidates;

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| • |  | the timing of the initiation and completion of pre-clinical studies and clinical trials;

| • |  | the timing of patient enrollment and dosing in any future clinical trials;

| • |  | the timing of the availability of data from clinical trials;

| • |  | expectations about the successful completion of clinical trials;

| • |  | obtaining regulatory and marketing approvals for product candidates for which we complete clinical trials;

| • |  | the timing of expected regulatory filings;

| • |  | expectations about approval by regulatory authorities of our drug candidates;

| • |  | the clinical utility and potential attributes and benefits of our product candidates, including the potential duration of treatment effects;

| • |  | potential licenses of intellectual property and collaborations;

| • |  | the commercialization of our product candidates, if approved;

| • |  | expectations regarding expenses, ongoing losses, future revenue and capital needs;

| • |  | our financial performance;

| • |  | the length of time over which we expect our cash and cash equivalents to be sufficient;

| • |  | our intellectual property position and the duration of our patent portfolio;

| • |  | maintaining, protecting and expanding our intellectual property portfolio, and avoiding infringing on intellectual property of third parties;

| • |  | establishing and maintaining successful licenses, collaborations and alliances with third parties;

| • |  | developing a sustainable, scalable, reproducible and transferable manufacturing process for our product candidates;

| • |  | establishing and maintaining supply and manufacturing relationships with third parties that can provide products and services adequate, in amount and quality, to support clinical development and commercialization of our product candidates, if approved;

| • |  | launching and commercializing any product candidates for which we obtain regulatory and marketing approval, either by collaborating with a partner or, if launched independently, by establishing a sales, marketing and distribution infrastructure;

| • |  | obtaining market acceptance of any product candidates that receive regulatory approval as viable treatment options;

| • |  | the outcome of corresponding endeavors in respect of competitive or potentially competitive product candidates by other drug development companies;

| • |  | obtaining favorable coverage and reimbursement rates for our products from third-party payers;

| • |  | addressing any competing technological and market developments;

| • |  | identifying and validating new product candidates; and

| • |  | negotiating favorable terms in any collaboration, licensing or other arrangements into which we may enter.

Even if one or more of our product candidates is approved for commercial sale, we may incur significant costs associated with commercializing any approved product candidate. As one example, our expenses could increase beyond expectations if we are required by the U.S. Food and Drug Administration (“FDA”) or other regulatory agencies, domestic or foreign, to perform clinical and other studies in addition to those that we currently anticipate. Even if we are able to generate revenues from the sale of any approved products, we may not become profitable and may need to obtain additional funding to continue operations, which could have an adverse effect on our business, financial condition, results of operations and prospects.

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We will need additional funding to operate our business; such funding may not be available or, if it is available, such financing is likely to substantially dilute our existing shareholders

During the year ended 30 June 2024 we raised A$4.6 million from the sale of ADSs. We will need to secure additional financing in order to continue to meet our longer-term business objectives, including advancement of our research and development programs and we may also require additional funds to pursue regulatory clearances, defend our intellectual property rights, establish commercial scale manufacturing facilities, develop marketing and sales capabilities and fund operating expenses. We intend to seek such additional funding through public or private financings and/or through licensing of our assets or strategic alliances or other arrangements with corporate partners.

Until we can generate a sufficient amount of product revenue to finance our cash requirements, which we may never achieve, we expect to finance our cash needs primarily through public or private equity offerings, debt financings or through strategic alliances. We cannot be certain that additional funding will be available on acceptable terms or at all. If we are not able to secure additional funding when needed, we may have to delay, reduce the scope of, or eliminate one or more of our clinical trials, collaborative research or development programs or future commercialisation initiatives. In addition, any additional funding that we do obtain will dilute the ownership held by our existing security holders. The amount of this dilution may be substantially increased if the trading price of our shares is lower at the time of any financing. Regardless, the economic dilution to shareholders will be significant if our stock price does not increase significantly, or if the effective price of any sale is below the price paid by a particular shareholder. Any debt financing could involve substantial restrictions on activities and creditors could seek a pledge of some or all of our assets. We have not identified potential sources for the additional financing that we will require, and we do not have commitments from any third parties to provide any future financing, other than the equity line program with Alumni Capital L.P., which is subject to certain restrictions. If we fail to obtain additional funding as needed, we may be forced to cease or scale back operations, and our results, financial condition and stock price would be adversely affected

The Company has two product candidates currently in clinical trials. Failure of one or both of these product candidates to show benefit to patients could materially and adversely affect the continuity of our business and our financial condition.

The Company’s lead programs include paxalisib (formerly GDC-0084), a small molecule inhibitor of the PI3K/Akt/mTOR pathway, and EVT801, a small molecule selective inhibitor of vascular endothelial growth factor receptor 3 (“VEGFR3”). However, even though progress has been made, such as the clinical validation of the PI3K/Akt/mTOR pathway as a target for oncology therapies, development of our product candidates may prove unsuccessful, after completion of clinical trials, due to any failure to provide adequate beneficial effect to cancer patients. It is possible that either or both product candidates may fail to show sufficient benefit as an intended treatment for the specific cancer indication to become commercially viable products, which could materially and adversely affect the continuity of our business and our financial condition.

The Company has ongoing clinical trials in which experimental therapies are administered to human subjects. If profound and unexpected safety concerns are encountered in clinical trials, it may materially and adversely affect the continuity of our business and our financial condition.

Despite all applicable efforts to characterize the safety profile of our drug development candidates through animal studies and other mechanisms, the possibility of unexpected safety concerns remains. If one or both of our clinical stage candidates were found to be associated with profound and unexpected toxicity or other safety concerns, the Company may be required to cease development of one or both candidates, and may additionally incur other impairments to the business including reputational damage, which may materially and adversely affect the continuity of our business and our financial condition.

There is substantial doubt about our ability to continue as a going concern, which may hinder our ability to obtain future financing.

The Company has limited cash resources and will periodically need additional funds to maintain the planned level of R&D activity. We expect to consume cash and incur operating losses for the foreseeable future as the Company continues developing its oncology drug candidates. The impact on cash resources and results from operations will vary with the extent and timing of future clinical trial programs. While it is not possible to make accurate predictions of future operating results, we expect existing cash and cash equivalents, including the capital raised under our ATM facility and equity line of credit facility with Alumni Capital L.P., will be sufficient to enable us to continue our research and development activities until approximately March 2025.

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As of 30 June 2024, we had cash on hand at the bank of A$1.7 million. The consolidated financial statements have been prepared on a going concern basis, which contemplates continuity of normal activities and realization of assets and settlement of liabilities in the normal course of business. As is often the case with drug development companies, our ability to continue as a going concern is dependent upon our ability to derive sufficient cash from investors, from licensing and partnering and collaboration activities and from other sources of revenue such as grant funding.

Furthermore, we are limited by General Instruction I.B.5 to Form F-3 (the “Baby Shelf Rule”) as of the filing of this Annual Report, until such time as our non-affiliate public float exceeds $75 million. The amount of funds we can raise through primary non-affiliate public offerings of securities in any 12-month period using our registration statement on Form F-3 is limited to one-third of the aggregate market value of the ordinary shares held by non-affiliates of the Company, which limitation may change over time based on our stock price, number of ordinary shares outstanding and the percentage of ordinary shares held by non-affiliates. These factors raise substantial doubt about our ability to continue as a going concern within one year after the date that the consolidated financial statements are issued. The independent auditor’s report for the fiscal year ended 30 June 2024 included an explanatory paragraph in relation to the going concern uncertainty.

If the Company is unable to obtain additional funds on favorable terms or at all, it may be required to cease or reduce its operations. Our future success is dependent upon our ability to obtain additional funding. There can be no assurance, however, that we will be successful in obtaining such funding in sufficient amounts, on terms acceptable to us, or at all. Also, if the Company raises more funds by selling additional securities, the ownership interests of holders of its securities will be diluted.

Global economic uncertainty caused by rising inflation, political instability, and conflicts and other events of geopolitical significance, such as the conflict between Russia and Ukraine, and the recent conflict between Israel and Gaza, could adversely affect our business and financial performance.

Negative global economic conditions may pose challenges to the Company’s business strategy, which relies on access to capital from financial markets and/or investment by other companies. Failure to obtain sufficient funding on acceptable terms could have a material adverse effect on our business, results of operations and financial condition. Negative conditions in the global economy, including credit markets and the financial services industry, have generally made equity and debt financing more difficult to obtain, and may negatively impact the Company’s ability to complete financing transactions. We are currently operating in a period of economic uncertainty and capital markets disruption, which has been significantly impacted by the geopolitical instability due to the ongoing military conflict between Russia and Ukraine and the recently erupted conflict between Israel and Gaza. Our business, financial condition, and results of operations may be materially adversely affected by the negative impact on the global economy and capital markets resulting from the conflict in Ukraine or any other geopolitical tensions. U.S. and global markets are experiencing volatility and disruption following the escalation of geopolitical tensions, including the military conflict between Russia and Ukraine and the recent conflict between Israel and Gaza as well as any additional escalations that may develop in the Middle East region. Although the length and impact of these ongoing military conflicts are highly unpredictable, the conflict in Ukraine and the recent conflict between Israel and Gaza have led to market disruptions, including significant volatility in commodity prices, credit and capital markets, as well as supply chain disruptions.

Additionally, various of Russia’s actions have led to sanctions and other penalties being levied by the U.S., Australia, the European Union, and other countries, as well as other public and private actors and companies, against Russia and certain other geographic areas, including agreement to remove certain Russian financial institutions from the Society for Worldwide Interbank Financial Telecommunication payment system and restrictions on imports of Russian oil, liquified natural gas and coal. Additional potential sanctions and penalties have also been proposed and/or threatened. Russian military actions and the resulting sanctions could further adversely affect the global economy and financial markets and lead to instability and lack of liquidity in capital markets, potentially making it more difficult for us to obtain additional funds.

The duration and severity of these conditions is uncertain, as is the extent to which they may adversely affect the Company’s business and the business of current and prospective vendors and collaborators. If negative global economic conditions persist or worsen, the Company may be unable to secure additional funding to sustain its operations or to find suitable collaborators to advance its internal programs, even if positive results are achieved from research and development efforts.

Any of the above-mentioned factors could affect our business, prospects, financial condition, and operating results. The extent and duration of the military action, sanctions, and resulting market disruptions are impossible to predict, but could be substantial.

If we are unable to raise sufficient funding on acceptable terms due to these or other factors, we may be unable to continue to operate. There is no assurance that we will be successful in obtaining sufficient financing on acceptable terms and conditions to fund continuing operations, if at all. Our failure to obtain sufficient funds on acceptable terms when needed could have a material adverse effect on our business, results of operations and financial condition.

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Risks Related to Our Business Operations

We may not successfully engage in strategic transactions or enter into new collaborations, which could adversely affect our ability to develop and commercialize product candidates, impact our cash position, increase our expenses and present significant distractions to our management.

From time to time, we may consider additional strategic transactions, such as collaborations, acquisitions, asset purchases or sales and out- or in-licensing of product candidates or technologies. In particular we will evaluate and, if strategically attractive, seek to enter into additional collaborations, including with major biotechnology or pharmaceutical companies. The competition for collaborators is significant, and the negotiation process is time-consuming and complex. Any new collaboration may be on terms that are not optimal for us, and we may not be able to maintain any new or existing collaboration if, for example, development or approval of a product candidate is delayed, sales of an approved product candidate do not meet expectations or the collaborator discontinues the collaboration. Any such collaboration, or other strategic transaction, may require us to incur non-recurring or other charges, increase our expenditures, pose significant integration or implementation challenges or disrupt our management or business.

These transactions would entail numerous operational and financial risks, including exposure to unknown liabilities, incurrence of substantial debt or dilutive issuances of equity securities to pay transaction consideration or costs, higher than expected collaboration, acquisition or integration costs, write-downs of assets or goodwill or impairment charges, increased amortization expenses, difficulty and cost in facilitating the collaboration or combining the operations and personnel of any acquired business, impairment of relationships with key suppliers, manufacturers or customers of any acquired business due to changes in management and ownership and the inability to retain key employees of any acquired business.

Accordingly, although there can be no assurance that we will undertake or successfully complete any additional transactions of the nature described above, any transactions that we do complete may be subject to the foregoing or other risks and have a material adverse effect on our business, results of operations, financial condition and prospects. Conversely, any failure to enter any collaboration or other strategic transaction that would be beneficial to us could delay and make more expensive the development and potential commercialization of our product candidates and have a negative impact on the competitiveness of any product candidate that reaches market.

Any inability to attract and retain qualified key management and technical personnel would impair our ability to implement our business plan.

Our success largely depends on the continued service of key management and other specialized personnel. The loss of one or more members of our management team or other key employees or advisors could delay or increase the cost of our research and development programs and materially harm our business, financial condition, results of operations and prospects. The relationships that our key managers have cultivated within our industry make us particularly dependent upon their continued employment with us. We are dependent on the continued service of our technical personnel because of the highly technical nature of our product candidates and the specialized nature of the regulatory approval process for our product candidates. Because our management team and key employees are not obligated to provide us with continued service, they could terminate their employment with us at any time without penalty. We do not maintain key person life insurance policies on any of our management team members or key employees. Our future success will depend in large part on our continued ability to attract and retain other highly qualified scientific, technical and management personnel, as well as personnel with expertise in clinical testing, manufacturing, governmental regulation and commercialization. We face competition for personnel from other companies, universities, public and private research institutions, government entities and other organizations.

The Company previously identified material weaknesses in connection with its internal control over financial reporting. Although the Company has taken steps to remediate these material weaknesses, the Company may identify other material weaknesses in the future, which could have a significant adverse effect on its business and the trading price of the ADSs.

For the year ended 30 June 2024, pursuant to Section 404 of the Sarbanes-Oxley Act, the Company was required to furnish a report by our senior management on our internal control over financial reporting. This report is required to include disclosure of any material weaknesses identified by the Company’s management in its internal control over financial reporting. However, while the Company remains an non-accelerated filer, it will not be required to include an attestation report on internal control over financial reporting issued by the Company’s independent registered public accounting firm. To achieve compliance with Section 404 of the Sarbanes-Oxley Act, the Company has been engaged in a process to document and evaluate its internal control over financial reporting, which is both costly and challenging. In this regard, the Company will need to continue to dedicate internal resources, potentially continue to engage outside consultants and adopt a detailed work plan to assess and document the adequacy of internal control over financial reporting, continue steps to improve control processes as appropriate, validate through testing that controls are functioning as documented and implement a continuous reporting and improvement process for internal control over financial reporting.

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Management previously reported, in the Company’s Annual Report for the year ended 30 June 2023, a material weakness in its internal control over financial reporting related to the incorrect application of accounting standards in relation to the acquisition of the EVT-801 intangible asset and the related contingent consideration. The calculation was found to contain errors as discounting for the time value of money was not considered on initial recognition. This was the result of a lack of personnel with specialist accounting knowledge. The material weakness as reported in the Company’s Annual Report for the year ended 30 June 2023 has been remediated.

Our collaborations with outside scientists and consultants may be subject to restriction and change.

We work with medical experts, chemists, biologists and other scientists at academic and other institutions, and consultants who assist us in our research, development and regulatory efforts, including the members of our scientific advisory board. In addition, these scientists and consultants have provided, and we expect that they will continue to provide, valuable advice regarding our programs and regulatory approval processes. These scientists and consultants are not our employees and may have other commitments that would limit their future availability to us. If a conflict of interest arises between their work for us and their work for another entity, we may lose their services. In addition, we are limited in our ability to prevent them from establishing competing businesses or developing competing products. For example, if a key scientist acting as a principal investigator in any of our future clinical trials identifies a potential product or compound that is more scientifically interesting to professional interests, their availability to remain involved in any future clinical trials could be restricted or eliminated.

We face potential product liability claims, and, if successful claims are brought against us, we may incur substantial liability and costs. If the use of our product candidates harms patients, or is perceived to harm patients even when such harm is unrelated to our product candidates, our regulatory approvals could be revoked or otherwise negatively impacted and we could be subject to costly and damaging product liability claims.

The use of our product candidates in clinical trials and the sale of any products for which we may in the future obtain marketing approval exposes us to the risk of product liability claims. Product liability claims might be brought against us by consumers, healthcare providers, pharmaceutical companies or others selling or otherwise coming into contact with our product candidates. There is a risk that our product candidates may induce adverse events. If we cannot successfully defend against product liability claims, we could incur substantial liability and costs. In addition, regardless of merit or eventual outcome, product liability claims may result in:

| • |  | impairment of our business reputation;

| • |  | withdrawal of clinical trial participants;

| • |  | costs due to related litigation;

| • |  | distraction of management’s attention from our primary business;

| • |  | substantial monetary awards to patients or other claimants;

| • |  | the inability to commercialize our product candidates;

| • |  | decreased demand for our product candidates, if approved for commercial sale; and

| • |  | increased cost, or impairment of our ability, to obtain or maintain product liability insurance coverage.

We may use our limited financial and human resources to pursue a particular research program or product candidate and fail to capitalize on programs or product candidates that may be more profitable or for which there is a greater likelihood of success.

Because we have limited resources, we may forego or delay pursuit of opportunities with certain programs or product candidates or for indications that later prove to have greater commercial potential. Our resource allocation decisions may cause us to fail to capitalize on viable commercial products or profitable market opportunities. Our spending on current and future research and development programs for product candidates may not yield any commercially viable products. If we do not accurately evaluate the commercial potential or target market for a particular product candidate, we may relinquish valuable rights to that product candidate through strategic collaboration, licensing or other royalty arrangements in cases in which it would have been more advantageous for us to retain sole development and commercialization rights to such product candidate, or we may allocate internal resources to a product candidate in a therapeutic area in which it would have been more advantageous to enter into a collaboration arrangement.

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Our internal computer and information technology systems, or those of our collaborators and other development partners, third-party Contract Research Organizations (“CROs”) or other contractors or consultants, may fail or suffer security breaches, which could result in a disruption of our product development programs.

Despite the implementation of security measures, our internal computer and information technology systems and those of our current and any future CROs and other contractors, consultants and collaborators are vulnerable to damage from computer viruses, cyber-attacks, unauthorized access, natural disasters, terrorism, war and telecommunication and electrical failures. Such events could cause interruptions of our operations. While we have not experienced any material system failure, accident or security breach to date, if such an event were to occur and cause interruptions in our operations, it could result in a disruption of our development programs and our business operations, whether due to a loss of our trade secrets or other similar disruptions. One of our major suppliers did experience a cyber attack in April 2023 but it did not result in any material system failure and had no long term impact on our business. For example, the loss of clinical trial data from ongoing or future clinical trials or data from pre-clinical studies could result in delays in our regulatory approval efforts and significantly increase our costs to recover or reproduce the data. Likewise, we rely on third parties to manufacture our product candidates and will rely on third parties to conduct future clinical trials, and similar events relating to their computer systems could also have similar consequences to our business. To the extent that any disruption or security breach were to result in a loss of, or damage to, our data or applications, or inappropriate disclosure of confidential or proprietary information, we could incur liability and the further development and commercialization of our product candidates could be delayed and become more expensive.

Our ability to utilize our net operating losses and certain other tax attributes may be limited.

We have substantial carried forward tax losses which may not be available to offset any future assessable income. In order for an Australian corporate taxpayer to carry forward and utilize tax losses, the taxpayer must pass either the continuity of ownership test (the “COT”), or, if it fails the COT, the same business test (“SBT”), or similar business test, in respect of relevant tax losses.

We have not carried out any formal analysis as to whether we have met the COT or, failing the COT, the SBT or similar business test over relevant periods. In addition, future shareholding changes may result in a significant ownership change for us. It is therefore uncertain as to whether any of our tax losses carried forward as of 30 June 2024 will be available to be carried forward and available to offset our assessable income, if any, in future periods.

Risks Related to the Product Development and Regulatory Approval of Our Product Candidates

We may not be able to obtain orphan drug exclusivity, where relevant, in all markets for our product candidates.

Regulatory authorities in some jurisdictions, including the United States, may designate drugs for relatively small patient populations as orphan drugs. Under the Orphan Drug Act, the FDA may designate a product as an orphan drug if it is a product intended to treat a rare disease or condition, which is generally defined as a patient population of fewer than 200,000 individuals annually in the United States. The FDA may also designate a product as an orphan drug if it is intended to treat a disease or condition of more than 200,000 individuals in the United States and there is no reasonable expectation that the cost of developing and making a drug or biological product available in the United States for this type of disease or condition will be recovered from sales of the product candidate.

Generally, if a product with an orphan drug designation subsequently receives the first marketing approval for the indication for which it has such designation, the product is entitled to a period of marketing exclusivity, which precludes the FDA from approving another marketing application for the same drug for such indication for that time period. The applicable period is seven years in the United States. Orphan drug exclusivity may be lost if the FDA determines that the request for designation was materially defective or if the manufacturer is unable to assure sufficient quantity of the drug to meet the needs of patients with the rare disease or condition.

Paxalisib (formerly GDC-0084) was granted orphan drug designation by the FDA in February 2018 for the treatment of glioblastoma, in August 2020 for the treatment of malignant glioma, which includes diffuse intrinsic pontine glioma (“DIPG”), a rare and highly aggressive childhood brain cancer, and in June 2022 for the treatment of atypical rhabdoid / teratoid tumors (“AT/RT”). However, even if we obtain orphan drug exclusivity for additional products in the United States or other jurisdictions, that exclusivity may not effectively protect the product from competition because different drugs can be approved for the same condition, and the same drug could be approved for a different condition. Moreover, even after an orphan drug is approved, the FDA can subsequently approve the same drug, made by a competitor, for the same condition if the FDA concludes that the competitive product is clinically superior in that it is shown to be safer, more effective or makes a major contribution to patient care.

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Positive results from pre-clinical studies of our product candidates are not necessarily predictive of the results of our planned clinical trials of our product candidates.

Positive results in pre-clinical proof of concept and animal studies of our product candidates may not result in positive results in clinical trials in humans. Many companies in the pharmaceutical and biotechnology industries have suffered significant setbacks in clinical trials after achieving positive results in pre-clinical development or early-stage clinical trials, and we cannot be certain that we will not face similar setbacks. These setbacks have been caused by, among other things, pre-clinical findings made while clinical trials were underway or safety or efficacy observations made in clinical trials, including adverse events. Moreover, pre-clinical and clinical data are often susceptible to varying interpretations and analyses, and many companies that believed their product candidates performed satisfactorily in pre-clinical studies and clinical trials nonetheless failed to obtain FDA or other regulatory authority approval. If we fail to produce positive results in our clinical trials of our product candidates, the development timeline and regulatory approval and commercialization prospects for our product candidates, and, correspondingly, our business and financial prospects, would be negatively impacted.

Even if the Company receives regulatory approval to commercialize its drug candidates, the ability to generate revenues from any resulting products will be subject to a variety of risks, many of which are out of the Company’s control.

Regardless of regulatory approval, products arising from the development process may not gain market acceptance among physicians, patients, healthcare payers or the medical community. The Company believes that the degree of market acceptance and its ability to generate revenues from such products will depend on a number of factors, including, but not limited to:

| • |  | advancements in the treatment of cancer that make our treatments obsolete;

| • |  | market exclusivity and competitor products;

| • |  | timing of market introduction of the Company’s drugs and competitive drugs;

| • |  | actual and perceived efficacy and safety of the Company’s drug candidates;

| • |  | prevalence and severity of any side effects;

| • |  | potential or perceived advantages or disadvantages over alternative treatments;

| • |  | strength of sales, marketing and distribution support;

| • |  | price of future products, both in absolute terms and relative to alternative treatments;

| • |  | the effect of current and future healthcare laws on the Company’s drug candidates; and

| • |  | availability of coverage and reimbursement from government and other third-party payers.

If any of the Company’s drugs are approved and fail to achieve market acceptance, the Company may not be able to generate significant revenue to achieve or sustain profitability.

Risks Related to Commercialization of Our Product Candidates

The Company may not be able to establish the contractual arrangements necessary to develop, market and distribute the product candidates. Our failure to do so may adversely affect our business, results of operations and financial condition.

The Company has been successful in executing contractual agreements with strategic partners. This remains a key part of the Company’s business plan and the Company must continue to partner with third parties to manufacture clinical grade drug product and conduct key pre-clinical and clinical investigations. Strategic agreements around packaging, branding, market access and distribution for its drug products will also eventually be required.

However, potential partners could be discouraged by the Company’s limited operating history. There is no assurance that the Company will be able to negotiate commercially acceptable licensing or other agreements for the future exploitation of its drug product candidates including continued clinical development, manufacture or marketing. If the Company is unable to successfully contract for these services, or if arrangements for these services are terminated, the Company may have to delay the commercialization program which will adversely affect its ability to generate operating revenues.

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The Company’s commercial opportunity will be reduced or eliminated if competitors develop and market products, devices or other treatments that are more effective, have fewer side effects or are less expensive than its drug candidates.

The development of drug candidates is highly competitive and is high risk. A number of other companies have products or drug candidates in various stages of pre-clinical or clinical development that are intended for the same therapeutic indications for which the Company’s drug candidates are being developed. Some of these potential competing drugs are further advanced in development than the Company’s drug candidates and may be commercialized sooner. Even if the Company is successful in developing effective drugs, its compounds may not compete successfully with products produced by its competitors.

The Company’s competitors include pharmaceutical companies and biotechnology companies, as well as universities and public and private research institutions. In addition, companies active in different but related fields represent substantial competition. Many of the Company’s competitors developing oncology drugs have significantly greater capital resources, larger R&D staff and facilities and greater experience in drug development, regulation, manufacturing and marketing. These organizations also compete with the Company and its service providers, to recruit qualified personnel, and to attract partners for joint ventures and to license technologies. As a result, the Company’s competitors may be able to develop technologies and products that would render the Company’s technologies or its drug candidates obsolete or non-competitive.

Risks Related to Our Intellectual Property

If we are unable to protect intellectual property rights related to our product candidates, we may not be able to obtain exclusivity for our product candidates or prevent others from developing similar competitive products.

We rely upon a combination of patents, know-how, trade secret protection and confidentiality agreements to protect the intellectual property related to our product candidates. The strength of patents in the biotechnology and pharmaceutical field involves complex legal and scientific questions and can be uncertain. The patent applications that we own or in-license may fail to result in issued patents with claims that cover our product candidates in the United States or other jurisdictions. In addition, we cannot guarantee that any patents will issue from any pending or future patent applications owned by or licensed to us. There is no assurance that all of the potentially relevant prior art relating to our patents and patent applications has been found. If such prior art exists, it can invalidate a patent or prevent a patent from issuing from a pending patent application. Even if patents do successfully issue and even if such patents cover our product candidates, third parties may initiate opposition, interference, re-examination, post-grant review, inter parties review, nullification or derivation action in court or before patent offices or similar proceedings challenging the validity, enforceability or scope of such patents, which may result in the patent claims being narrowed or invalidated. Furthermore, even if our patents and patent applications are unchallenged, they may not adequately protect our intellectual property, provide exclusivity for our product candidates or prevent others from designing around our claims. Any of these outcomes could impair our ability to prevent competition from third parties.

If the patent applications we hold or have in-licensed with respect to our programs or product candidates fail to issue, or are revoked, if the breadth or strength of our patent protection is threatened, or if our patent portfolio fails to provide meaningful exclusivity for our product candidates, it could dissuade companies from collaborating with us to develop product candidates and threaten our ability to commercialize future products. Any successful opposition to any patents owned by or licensed to us could deprive us of rights necessary for the successful commercialization of any product candidates that we may develop. Further, if we encounter delays in regulatory approvals, the period of time during which we could market a product candidate under patent protection could be reduced. Even where we have a valid and enforceable patent, we may not be able to exclude others from practicing our invention where the other party can show that they used the invention in commerce before our filing date or the other party benefits from a compulsory license. In addition, patents have a limited lifespan. In the United States, the natural expiration of a patent is generally 20 years after it is filed. Various extensions may be available, but the life of a patent, and the protection it affords, is limited. Even if patents covering our product candidates are obtained, once the patent life has expired for a product, we may be open to competition from competitive medications, including biosimilar or generic medications. This risk is material in light of the length of the development process of our products and lifespan of our current patent portfolio.

In addition to the protection afforded by patents, we rely on trade secret protection and confidentiality agreements to protect proprietary know-how that is not patentable or that we elect not to patent, processes for which patents are difficult to enforce and any other elements of our product candidate discovery and development processes that involve proprietary know-how, information or technology that is not covered by patents. However, trade secrets can be difficult to protect. What constitutes a trade secret and what

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protections are available for trade secrets varies from state to state in the United States and country by country worldwide. We seek to protect our proprietary technology and processes, in part, by entering into confidentiality agreements with our employees, consultants, scientific advisors and contractors. We also seek to preserve the integrity and confidentiality of our data and trade secrets by maintaining physical security of our premises and physical and electronic security of our information technology systems. Security measures may be breached, and we may not have adequate remedies for any breach. In addition, our trade secrets may otherwise become known or be independently discovered by competitors. Although we expect all of our employees and consultants to assign their inventions to us, and all of our employees, consultants, advisors and any third parties who have access to our proprietary know-how, information or technology to enter into confidentiality agreements, we cannot provide any assurances that all such agreements have been duly executed or that our trade secrets and other confidential proprietary information will not be disclosed or that competitors will not otherwise gain access to our trade secrets or independently develop substantially equivalent information and techniques.

Obtaining and maintaining our patent protection depends on compliance with various procedural, document submission, fee payment and other requirements imposed by governmental patent agencies, and our patent protection could be reduced or eliminated for non-compliance with these requirements.

Periodic maintenance fees, renewal fees, annuity fees and various other governmental fees on patents and applications are required to be paid to the USPTO and various governmental patent agencies outside of the United States in several stages over the lifetime of the patents and applications. The USPTO and various corresponding governmental patent agencies outside of the United States require compliance with a number of procedural, documentary, fee payment and other similar provisions during the patent application process and after a patent has issued. There are situations in which non-compliance can result in abandonment or lapse of the patent or patent application, resulting in partial or complete loss of patent rights in the relevant jurisdiction.

Our success depends, in part, on our ability to protect our intellectual property and our technologies.

Our commercial success depends, in part, on our ability to obtain and maintain patent and trade secret protection for our technologies, our traits, and their uses, as well as our ability to operate without infringing upon the proprietary rights of others. If we do not adequately protect our intellectual property, competitors may be able to use our technologies and erode or negate any competitive advantage we may have, which could harm our business and ability to achieve profitability.

Filing, prosecuting and defending patents on product candidates in all countries around the world would be prohibitively expensive. In addition, we may at times in-license third-party technologies for which limited international patent protection exists and for which the time period for filing international patent applications has passed. Consequently, we may not be able to prevent third parties from practicing our inventions, or from selling or importing products made using our inventions. Potential competitors may use our technologies in jurisdictions where we have not obtained patent protection to develop their own products and further, may export otherwise infringing products to territories where we have patent protection but enforcement is difficult. These products may compete with our product candidates, if approved, and our patents or other intellectual property rights may not be effective or sufficient to prevent them from competing.

Many companies have encountered significant problems in protecting and defending intellectual property rights around the world. The legal systems of certain countries, particularly certain developing countries, do not favor the enforcement of patents, trade secrets and other intellectual property protection, particularly those relating to biotechnology products, which could make it difficult for us to stop the infringement of our patents or marketing of competing products in violation of our proprietary rights generally. Proceedings to enforce our patent rights could result in substantial costs and divert our efforts and attention from other aspects of our business, could put our patents at risk of being invalidated or interpreted narrowly and our patent applications at risk of not issuing and could provoke third parties to assert claims against us. We may not prevail in any lawsuits that we initiate and the damages or other remedies awarded, if any, may not be commercially meaningful. Accordingly, our efforts to enforce our intellectual property rights around the world may be inadequate to obtain a significant commercial advantage from the intellectual property that we develop or license.

Risks Related to Our Reliance on Third Parties

The Company relies on third parties to conduct its pre-clinical studies and clinical trials. If those parties do not successfully carry out their contractual duties or meet expected deadlines, the Company’s drug candidates may not advance in a timely manner or at all.

In the course of discovery, pre-clinical testing and clinical trials, the Company relies on third parties, including laboratories, investigators, clinical CROs, and manufacturers, to perform critical services. For example, the Company relies on third parties to

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conduct all of its pre-clinical and clinical studies. These third parties may not be available when the Company needs them or, if they are available, may not comply with all regulatory and contractual requirements or may not otherwise perform their services in a timely or acceptable manner, and the Company may need to enter into new arrangements with alternative third parties and the studies may be extended, delayed or terminated. These independent third parties may also have relationships with other commercial entities, some of which may compete with the Company. As a result of the Company’s dependence on third parties, it may face delays or failures outside of its direct control. These risks also apply to the development activities of collaborators, and the Company does not control their research and development, clinical trial or regulatory activities.

The Company has no direct control over the cost of manufacturing its drug candidates. Increases in the cost of manufacturing the Company’s drug candidates would increase the costs of conducting clinical trials and could adversely affect future profitability.

The Company does not intend to manufacture the drug product candidates in-house, and it will rely on third parties for drug supplies both for clinical trials and for commercial quantities in the future. The Company has taken the strategic decision not to manufacture active pharmaceutical ingredients (“API”) for the drug candidates, as these can be more economically supplied by third parties with particular expertise in this area. The Company outsources the manufacture of its drug products and their testing to FDA requirements. The Company uses contract facilities that are registered with the FDA, have a track record of large-scale API manufacture, and have already invested in capital and equipment. The Company has no direct control over the cost of manufacturing its product candidates. If the cost of manufacturing increases, or if the cost of the materials used increases, these costs may be passed on, making the cost of conducting clinical trials more expensive. Increases in manufacturing costs could adversely affect the Company’s future profitability if it was unable to pass all of the increased costs along to its customers.

The Company relies on third-party contract manufacturing organizations to manufacture its drug product candidates. If one or more of these vendors were unable to meet the Company’s needs, it may materially and adversely impact our business.

Manufacture of pharmaceutical material for human administration is technically complex and highly regulated. If one or more of the Company’s vendors failed to produce drug product to the requisite standard, the continuity of the Company’s operations may be severely disrupted. Even if a vendor was found deficient in respect of another product, it may impair the confidence of regulatory agencies in our product candidates, thereby disrupting our operations.

Global contract manufacturing capacity is limited, and the manufacturing process is not readily portable. As a result, the Company’s ability to manufacture its product candidates in a timely manner is dependent on the availability of suitable capacity at its vendors.

The manufactured drug products, and their intermediaries, are of significant financial value. Loss, damage, or theft of this material, for example while in storage or transit, may result in significant detriment to the Company, which may be incompletely cured by insurance.

Risks Related to our Securities

Enforceability of civil liabilities under the federal securities laws against the Company or the Company’s officers and directors may be difficult.

The Company is a public company limited by shares and is registered and operates under the Corporations Act 2001 (Cth) (“Corporation Act”). Half of the Company’s directors and officers reside outside of the United States. In addition, a substantial portion of the directly owned assets of the Company are located outside of the United States. As a result, it may be difficult or impossible for investors to effect service of process within the United States against the Company or its directors and officers or to enforce against them any of the judgments, including those obtained in original actions or in actions to enforce judgments of the U.S. courts, predicated upon the civil liability provisions of the federal or state securities laws of the United States. There is doubt as to the enforceability in the Commonwealth of Australia, in original actions or in actions for enforcement of judgments of U.S. courts, of civil liabilities predicated solely upon federal or state securities laws of the U.S., especially in the case of enforcement of judgments of U.S. courts where the defendant has not been properly served in Australia.

The Company’s failure to meet the continued listing requirements of Nasdaq could result in a delisting of the ADSs, which could negatively impact the market price and liquidity of the Company’s securities and its ability to access the capital markets.

The ADSs are listed on the Nasdaq Capital Market. If the Company fails to satisfy the continued listing requirements of Nasdaq, such as the corporate governance requirements or the minimum closing bid price requirement, Nasdaq may take steps to delist the ADSs. Such a delisting would have a negative effect on the price of the Company’s securities, impair the ability to sell or purchase our

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common stock when persons wish to do so, and any delisting materially adversely affect the Company’s ability to raise capital or pursue strategic restructuring, refinancing or other transactions on acceptable terms, or at all. Delisting from the Nasdaq Capital Market could also have other negative results, including the potential loss of institutional investor interest and fewer business development opportunities. In the event of a delisting, the Company would attempt to take actions to restore its compliance with Nasdaq’s listing requirements, but the Company can provide no assurance that any such action taken by it would allow the ADSs to become listed again, stabilize the market price or improve the liquidity of the ADSs, prevent the ADSs from dropping below the Nasdaq minimum bid price requirement or prevent future non-compliance with Nasdaq’s listing requirements.

On 20 November, 2023, the Company received a notice from the Nasdaq Listing Qualifications Department of The Nasdaq Stock Market LLC (“Nasdaq”) informing the Company that because the closing bid price of the ADSs had been below US$1.00 per share for 30 consecutive business days, the Company no longer complied with the minimum bid price requirement for continued listing on The Nasdaq Capital Market. Nasdaq Listing Rule 5550(a)(2) (the “Rule”) requires listed securities to maintain a minimum bid price of US$1.00 per share, and Listing Rule 5810(c)(3)(A) provides that a failure to meet the minimum bid price requirement exists if the deficiency continues for a period of 30 consecutive business days. The notice had no immediate effect on the listing or the trading of the ADSs on The Nasdaq Capital Market. Pursuant to Nasdaq Marketplace Rule 5810(c)(3)(A), the notice letter stated that the Company had an initial compliance period of 180 calendar days, or until May 20, 2024, to regain compliance with the minimum bid price requirement.

On 22 May, 2024, the Company received a letter from Nasdaq notifying the Company that, while the Company has not regained compliance with the Minimum Bid Price Requirement, Nasdaq has determined that the Company is eligible for an additional 180 calendar day period, or until 18 November, 2024 (the “Second Compliance Period”), to regain compliance with the minimum bid price requirement. If at any time during the Second Compliance Period the closing bid price of the Company’s security is at least $1.00 per share for a minimum of 10 consecutive business days, Nasdaq will provide written confirmation of compliance.

Nasdaq’s determination was based on the Company meeting the continued listing requirement for market value of publicly held shares and all other applicable requirements for initial listing on The Nasdaq Capital Market, with the exception of the minimum bid price requirement, and the Company’s written notice to Nasdaq of its intention to cure the deficiency during the Second Compliance Period and, if necessary, by effecting a ratio change of the ADSs. There can be no assurance that the Company will regain compliance with the Minimum Bid Price Requirement during the Second Compliance Period.

On 15 October 2024, Kazia announced that it planned to effect an ADS ratio change to change the ratio of ADSs to ordinary shares from one ADS to ten ordinary shares to the new ratio of one ADS to one-hundred ordinary shares. The ADS ratio change will have the same effect as a one-for-ten reverse ADS split for Kazia’s ADS holders. There will be no change to Kazia’s underlying ordinary shares, and no ordinary shares will be issued or cancelled in connection with the ADS ratio change. The ADS ratio change became effective on 28 October 2024.

The trading price of the ADSs is highly volatile. Your investment could decline in value and the Company may incur significant costs from class action litigations.

The trading price of the ADSs is highly volatile in response to various factors, many of which are beyond the Company’s control, including:

| • |  | unacceptable toxicity findings in animals and humans;

| • |  | lack of efficacy in human trials at Phase II stage or beyond;

| • |  | announcements of technological innovations by the Company and its competitors;

| • |  | new products introduced or announced by the Company or its competitors;

| • |  | changes in financial estimates by securities analysts;

| • |  | actual or anticipated variations in operating results;

| • |  | expiration or termination of licenses, research contracts or other collaboration agreements;

| • |  | conditions or trends in the regulatory climate in the biotechnology, pharmaceutical and genomics industries;

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| • |  | changes in the market values of similar companies;

| • |  | changes in the broader macroeconomic environment;

| • |  | the liquidity of any market for the Company’s securities; and

| • |  | additional sales by the Company of its shares.

In addition, equity markets in general and the market for biotechnology and life sciences companies in particular, have experienced substantial price and volume fluctuations that have often been unrelated or disproportionate to the operating performance of the companies traded in those markets. Further changes in economic conditions in Australia, the U.S., EU, or globally, could impact the Company’s ability to grow profitably. Adverse economic changes are outside the Company’s control and may result in material adverse effects on the Company’s business or results of operations. These broad market and industry factors may materially affect the market price of the Company’s the ADSs regardless of its development and operating performance. In the past, following periods of volatility in the market price of a company’s securities, securities class action litigation has often been instituted against that company. Such litigation, if instituted against the Company, could cause it to incur substantial costs and divert management’s attention and resources.

If the market price of the ADSs falls and remains below US$5.00 per share, under stock exchange rules, the Company’s stockholders will not be able to use such ADSs as collateral for borrowing in margin accounts. This inability to use ADSs as collateral may depress demand as certain institutional investors are restricted from investing in securities priced below US$5.00 and may lead to sales of such ADSs, creating downward pressure on and increased volatility in the market price of the Company’s ordinary shares and ADSs.

The delisting of the Company’s ordinary shares on the ASX may adversely affect the price, liquidity and value of the ADSs.

On 11 October 2023, the Company announced its intention to delist from the Australian Securities Exchange (the “ASX”), which became effective on 15 November 2023. Upon completion of the delisting, the Company’s ordinary shares were no longer quoted or traded on the ASX and only the ADSs are listed on the Nasdaq Capital Market, and as a result, shareholders were no longer able to trade their ordinary shares on the ASX. Following the completion of the delisting, the Company’s ordinary shares are only capable of being traded on Nasdaq in the form of ADSs, which will require shareholders to transfer their ordinary shares to ADSs to trade on Nasdaq and engage a suitably qualified Australian broker or a U.S. based broker who is able to trade on Nasdaq, or by off-market, private transactions, which will require shareholders to identify and agree terms with potential purchasers of ordinary shares. In addition, following the completion of the delisting, the Company will no longer be subject to the ASX Listing Rules. The Company cannot predict the effect of the proposed delisting on the value of the ADSs, however the delisting may restrict the liquidity of these securities by providing only one market on which to trade the Company’s securities, which may impair the development or liquidity of an active trading market for the ADSs in the U.S.

If the Company fails to comply with the rules under the Sarbanes-Oxley Act of 2002 related to accounting controls and procedures in the future, or, if the Company discovers material weaknesses and other deficiencies in our internal control and accounting procedures, the price of the ADSs could decline significantly and raising capital could be more difficult.

If the Company fails to comply with the rules under the Sarbanes-Oxley Act of 2002 related to disclosure controls and procedures in the future, or, if we discover material weaknesses and other deficiencies in our internal control and accounting procedures, our stock price could decline significantly and raising capital could be more difficult. Section 404 of the Sarbanes-Oxley Act requires annual management assessments of the effectiveness of our internal control over financial reporting. As of 30 June 2024, the Company’s management determined that we had no material weaknesses in our internal control over financial reporting. If material weaknesses or significant deficiencies are discovered or if the Company otherwise fails to achieve and maintain the adequacy of its internal controls, the Company may not be able to ensure that it can conclude on an ongoing basis that it has effective internal controls over financial reporting in accordance with Section 404 of the Sarbanes-Oxley Act. Moreover, effective internal controls are necessary for the Company to produce reliable financial reports and are important to helping prevent financial fraud. If the Company cannot provide reliable financial reports or prevent fraud, its business and operating results could be harmed, investors could lose confidence in its reported financial information, and the trading price of the ADSs could drop significantly.

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You are reliant on the depository to exercise your voting rights and to receive distributions on ADSs and, as a result, you may be unable to exercise your voting rights on a timely basis or you may not receive certain distributions.

In certain circumstances, holders of ADSs may have limited rights relative to holders of ordinary shares. The rights of holders of ADSs with respect to the voting of ordinary shares and the right to receive certain distributions may be limited in certain respects by the deposit agreement entered into by us and The Bank of New York Mellon. For example, although ADS holders are entitled under the deposit agreement, subject to any applicable provisions of Australian law and of our Constitution, to instruct the depositary as to the exercise of the voting rights pertaining to the ordinary shares represented by the ADSs, and the depositary has agreed that it will try, as far as practical, to vote the ordinary shares so represented in accordance with such instructions, ADS holders may not receive notices sent by the depositary in time to ensure that the depositary will vote the ordinary shares. This means that, from a practical point of view, the holders of ADSs may not be able to exercise their right to vote. Holders of ADSs in respect of which no timely voting instructions have been received shall be deemed to have instructed the depositary to give a discretionary proxy to a person designated by us to vote the ordinary shares represented by such holders’ ADSs; provided, however, that no such discretionary proxy shall be given with respect to any matter to be voted upon as to which we inform the depositary that (i) we do not wish such proxy to be given, (ii) substantial opposition exists, or (iii) the rights of holders of ordinary shares may be materially and adversely affected. In addition, under the deposit agreement, the depositary has the right to restrict distributions to holders of the ADSs in the event that it is unlawful or impractical to make such distributions. We have no obligation to take any action to permit distributions to holders of our ADSs. As a result, holders of ADSs may not receive distributions.

Holders of the ADSs are not treated as holders of our ordinary shares.

Holders of ADSs are not treated as holders of our ordinary shares, unless they withdraw the ordinary shares underlying their ADSs in accordance with the deposit agreement and applicable laws and regulations. The depositary is the holder of the ordinary shares underlying the ADSs. Holders of ADSs therefore do not have any rights as holders of our ordinary shares, other than the rights that they have pursuant to the Deposit Agreement.

You may be subject to limitations on transfer of the ADSs.

The ADSs are only transferable on the books of the depositary. However, the depositary may close its transfer books at any time or from time to time when it deems expedient in connection with the performance of its duties. In addition, the depositary may refuse to deliver, transfer or register transfers of ADSs generally when our books or the books of the depositary are closed, or at any time if we or the depositary deem it advisable to do so because of any requirement of law or of any government or governmental body, or under any provision of the Deposit Agreement, or for any other reason.

If we are, a passive foreign investment company, or PFIC, there could be adverse U.S. federal income tax consequences to U.S. investors.

Based on the composition of our assets and income in the 2023 taxable year, we believe that we were a PFIC for U.S. federal income tax purposes with respect to our 2023 taxable year. However, there can be no assurance that we will be considered a PFIC in the 2023 taxable year, the 2024 taxable year, the current year or for any future taxable year. Based on the composition of our assets and income in the 2024 taxable year, if we will not be a considered a PFIC in the 2023 taxable year, we believe that we were not a PFIC for U.S. federal income tax purposes with respect to our 2024 taxable year. However, even if we will not be a considered a PFIC in the 2023 taxable year, there can be no assurance that we will not be considered a PFIC in the 2024 taxable year, the current year or for any future taxable year. Our treatment as a PFIC could result in a reduction in the after-tax return to the U.S. holders of our ordinary shares or ADSs and would likely cause a reduction in the value of such ordinary shares or ADSs. For U.S. federal income tax purposes, we will be classified as a PFIC for any taxable year in which either (i) 75% or more of our gross income is passive income, or (ii) at least 50% of the average quarterly value of all of our assets for the taxable year produce or are held for the production of passive income. If we are classified as a PFIC for U.S. federal income tax purposes, highly complex rules will apply to U.S. holders owning ordinary shares or ADSs. Accordingly, you are urged to consult your tax advisors regarding the application of such rules. See Item 10-Additional Information-Taxation, United States Federal Income Tax Consequences for a more complete discussion of the U.S. federal income tax risks related to owning and disposing of our ordinary shares or ADSs.

We may lose our foreign private issuer status, which would then require us to comply with the Exchange Act’s domestic reporting regime and cause us to incur significant legal, accounting and other expenses.

We are a foreign private issuer. In order to maintain our current status as a foreign private issuer, at least 50% of our outstanding ordinary shares must continue to be either directly or indirectly owned of record by non-residents of the United States. If more than 50% of our outstanding ordinary shares are instead held by U.S. residents, then in order to continue to maintain our foreign private issuer status, (i) a majority of our executive officers or directors must not be U.S. citizens or residents, (ii) more than 50% of our assets must not be located in the United States, and (iii) our business must be administered principally outside the United States.

Losing our status as a foreign private issuer would require us to comply with all of the periodic disclosure and current reporting requirements of the Exchange Act applicable to U.S. domestic issuers. We also will be required to make changes in our corporate governance practices in accordance with various SEC and Nasdaq rules. The regulatory and compliance costs to us under U.S.

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securities laws, if we are required to comply with the reporting requirements applicable to a U.S. domestic issuer, would be significantly higher than the cost we would incur as a foreign private issuer. As a result, we would expect that a loss of foreign private issuer status will increase our legal and financial compliance costs and will make some activities highly time consuming and costly. We also expect that if we will be required to comply with the rules and regulations applicable to U.S. domestic issuers, it will make it more difficult and expensive for us to obtain director and officer liability insurance; we may therefore be required to accept reduced coverage or incur substantially higher costs to obtain coverage. These rules and regulations could also make it more difficult for us to attract and retain qualified members of our board of directors.

Australian takeover laws may discourage takeover offers being made for us or may discourage the acquisition of a significant position in our ordinary shares and ADSs.

We are incorporated in Australia and are subject to the takeover laws of Australia. Among other things, we are subject to the Corporations Act. Subject to a range of exceptions, the Corporations Act prohibits the acquisition of a direct or indirect interest in our issued voting shares if the acquisition of that interest will lead to a person’s voting power in us increasing to more than 20%, or increasing from a starting point that is above 20% and below 90%. Australian takeover laws may discourage takeover offers being made for us or may discourage the acquisition of a significant position in our ordinary shares. This may have the ancillary effect of entrenching our board of directors and may deprive or limit our shareholders’ and ADS holders’ opportunity to sell their ordinary shares and ADSs and may further restrict the ability of our shareholders and ADS holders to obtain a premium from such transactions. See Item 10.B “Additional Information - Our Constitution.”

Item 4. | Information on the Company

A. History and development of the Company

Kazia Therapeutics Limited (“Kazia” or the “Company”), a public company limited by shares, was incorporated in March 1994 and registered in New South Wales, Australia. Kazia is registered and operates under the Corporations Act.

Kazia has its registered office at Three International Towers, Level 24, 300 Barangaroo Avenue, Sydney, NSW 2000, Australia. Its telephone number and other contact details are: Phone +61-2-9472 4101; email info@kaziatherapeutics.com; and website, www.kaziatherapeutics.com (the information contained in the website does not form part of the Annual Report). Our agent for service of process in the United States is Vcorp Services, LLC, 25 Robert Pitt Drive, Suite 204, Monsey, New York 10952.

The Company’s ADSs, each representing one-hundred Ordinary Shares, trade on the Nasdaq Capital Market under the symbol ‘KZIA’. The Depositary for the Company’s ADSs is The Bank of New York Mellon, 240 Greenwich Street, New York, NY 10286. All information we file with the SEC is available through the SEC’s Electronic Data Gathering, Analysis and Retrieval system, which may be accessed through the SEC’s website at www.sec.gov.

B. Business overview

The ongoing principal business of the Company has been pharmaceutical drug development. The Company is an emerging oncology-focused biotechnology company that has a portfolio of development candidates, diversified across several distinct technologies, with the potential to yield first-in-class and best-in-class agents in a range of oncology indications.

Paxalisib

Kazia’s lead program is paxalisib, (formerly known as GDC-0084), an investigational brain-penetrant inhibitor of the PI3K / Akt / mTOR pathway, that was specifically designed to treat brain cancer.

Paxalisib was developed by Genentech, Inc (South San Francisco, California) and the company entered into a worldwide exclusive license for the asset in October 2016. Prior to this transaction, Genentech had completed an extensive pre-clinical development program that provided convincing validation for paxalisib as a potential drug for brain cancer. Genentech also completed a phase I clinical trial in 47 patients with advanced recurrent grade III and grade IV glioma (NCT01547546). The most common adverse events were oral mucositis and hyperglycemia. Per ANO criteria, 40% of patients exhibited a best observable response of stable disease, and 26% demonstrated a metabolic partial response on FDG-PET.

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The development candidate was granted the International Non-Proprietary Name (INN) ‘paxalisib’ by the World Health Organisation in December 2019. This was confirmed as the United States Adopted Name (“USAN”) by the USAN Council in April 2020. Paxalisib is orally administered and is presented in a 15mg capsule formulation. The development candidate is the subject of IND 112,608 with the U.S. Food and Drug Administration (“FDA”).

Paxalisib is a potent and selective inhibitor of all four isoforms of phosphoinositide-3-kinase (PI3K) and a moderate inhibitor of the mammalian target of rapamycin (“mTOR”). The PI3K / Akt / mTOR signaling axis has been shown to be dysregulated in approximately 85-90% of cases of glioblastoma, per Cancer Genome Atlas, and is considered a promising target in this disease. More generally, five PI3K inhibitors have thus far been approved by FDA, for a range of hematological malignancies and solid tumors, making this a well-validated target in cancer. Paxalisib is distinguished from these products by the fact that it is the only PI3K inhibitor in mainstream clinical development which is known to cross the blood-brain barrier, a crucial prerequisite for any novel treatment in brain cancer.

Paxalisib’s mechanism is therefore entirely distinct from that of temozolomide, the existing FDA-approved standard of care treatment. Temozolomide functions primarily by alkylating guanine residues in DNA, thereby inhibiting cell division in the rapidly-growing tumor. Paxalisib, by contrast, inhibits a biochemical control signal, and is therefore associated with a very different resistance and toxicity profile.

Paxalisib is the subject of granted or pending composition-of-matter patents in all key territories. In general, the expiry of these patents is in December 2031. However, the company expects that it will be able to secure patent term extensions in the most substantial markets, including US, EU, China, Japan, and Korea, and that these extensions will provide effective protection until 2036. In addition, the company has recently received notice of grant for a patent protecting the manufacturing process associated with paxalisib, and this will provide an additional layer of protection in relevant territories until 2036.

Paxalisib was granted orphan drug designation (“ODD”) by the FDA for glioblastoma in February 2018, and for the broader indication of glioma in August 2020 and ODD for atypical rhabdoid/teratoid tumours (“AT/RT”), a rare highly-aggressive childhood brain cancer, in June 2022. The development candidate also received Fast Track designation (“FTD”) for glioblastoma in August 2020, and Rare Pediatric Disease Designation (“RPDD”) for diffuse midline gliomas in August 2020. On July 6, 2023, Kazia announced that paxalisib had been awarded FTD by the FDA for the treatment of solid tumor brain metastases harboring PI3K pathway mutations in combination with radiation therapy. Collectively, these designations provide opportunities for enhanced access to FDA, a waiver of Prescription Drug Use Fee Act (“PDUFA”) fees, a period of regulatory exclusivity and, in the specific case of RPDD, the potential to secure a pediatric Priority Review Voucher (pPRV) should paxalisib be first approved in this indication.

Brain cancers account for about 15% of pediatric cancers and are the second most common type of cancer in children whereas over 300,000 adults are diagnosed every year with primary brain cancer. We believe paxalisib, by design, has the potential to be an integral component to precision medicine. As a targeted therapeutic, we have focused many of the ongoing trials to evaluate paxalisib in patients who have PI3K pathway mutations. Enrolling clinical trials with patients who have the potential to have the greatest response and benefits accelerates clinical trial recruitment and time to commercialization. The overall clinical development strategy for paxalisib has been crafted into three core pillars. Within the adult brain cancer pillar, we have four ongoing clinical studies across three different patient populations. There are two actively recruiting clinical studies and one recently completed study in the pediatric brain cancer pillar. Within the brain metastases pillar, there are three ongoing studies.

Paxalisib in Adult Brain Cancer

Glioblastoma (“GBM”) is a fast-growing and aggressive brain tumour. Paxalisib is being developed primarily for the ~65% of newly-diagnosed unmethylated GBM patients who generally do not respond to existing chemotherapy with temozolomide. The final data from a phase II study in newly diagnosed GBM patients reported promising signals of clinical activity with paxalisib and was presented at two global conferences in 2023.

GBM AGILE Pivotal study Phase II / III Clinical Trial in Glioblastoma (NCT03970447)

Paxalisib commenced recruitment to GBM AGILE a phase II / III adaptive clinical trial in glioblastoma, in January 2021. GBM AGILE (Glioblastoma Adaptive Global Innovative Learning Environment) is sponsored by the Global Coalition for Adaptive Research, a US-based 501©(3) non-profit organization dedicated to advancing the development of new therapies via the application of cutting-edge statistical methodologies. The goal is to expedite the approval of new drugs for this disease. The study is a platform study, or master protocol study, in which multiple experimental agents are evaluated in parallel, and are compared against a shared control arm. The paxalisib arm enrolled two patient populations: newly diagnosed patients with unmethylated MGMT promotor status, and recurrent patients.

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We announced on 1 August, 2022, that the company had been advised by GCAR that the first stage of the paxalisib arm had completed recruitment. The treatment arm did not meet pre-defined criteria for continuing to a second stage, and patients enrolled in the first stage of the paxalisib arm continued on treatment as per protocol, and in follow-up, until completion of the final analysis, which we anticipate receiving in 2H CY2023. Depending on the results of the study, Kazia may use such data to support submission of a new drug application for marketing authorisation to the FDA.

On 10 July, 2024, Kazia announced results from the GBM-AGILE study. A total of 313 newly diagnosed unmethylated (“NDU”) patients and recurrent patients being treated at top U.S. cancer hospitals were randomized to either a paxalisib treatment arm (up to 60 mg/day) or the Standard of Care (“SOC”) concurrent control arm from January 2021 to May 2022. For the primary analysis the median Overall Survival (“OS”) was 14.77 months for paxalisib-treated NDU patients (n=54) versus 13.84 months for cumulative SOC NDU patients (n=75). For a prespecified secondary analysis in the NDU patients, median OS was 15.54 months in the paxalisib arm (n=54) versus 11.89 months for concurrent SOC (n=46). In addition, a prespecified sensitivity analysis in NDU patients showed similar median OS difference between paxalisib treated patients (15.54 months) and concurrent SOC patients (11.70 months). An efficacy signal was not detected in the recurrent disease population (median OS of 9.69 months for concurrent SOC (n=113) versus 8.05 months for paxalisib (n=100).Based on the totality of data available from all completed paxalisib clinical studies in newly diagnosed unmethylated GBM patients, Kazia will request a meeting with the FDA to discuss the results and determine next steps for paxalisib, including potential regulatory paths for approval.

LUMOS2 phase II study

Kazia is supporting the University of Sydney on a molecularly guided phase II clinical study evaluating paxalisib in adult patients with recurrent/progressive isocitrate dehydrogenase (IDH) mutant grade 2 and 3 gliomas (G2/3 gliomas). The LUMOS2 study is sponsored by the University of Sydney with a goal of investigating targeted therapeutics in these patients who have limited options. The study is expected to enroll up to 76 patients with PI3K pathway mutations and will be a multicenter study at several Australian sites, with the potential to expand internationally. Enrollment in the study is ongoing.

Weill Cornell Medicine Phase II Study in Glioblastoma in Combination with Ketogenesis (NCT05183204)

In June 2021, the company entered into an agreement with Weill Cornell Medicine for an investigator-initiated phase II clinical trial combining paxalisib with ketogenesis in patients with newly- diagnosed and recurrent glioblastoma. The study is actively enrolling in two cohorts of GBM patients, and we anticipate providing an update to this study in 2025.

Dana Farber Cancer Institute (DFCI) Phase II Study in Primary Central Nervous System Lymphoma (PCNSL) (NCT04906096)

Professor Lakshmi Nayak is the Principal Investigator to a phase II clinical study of paxalisib in patients with primary CNS lymphoma (PCNSL) (NCT04906096). We believe the unique brain-penetrant qualities of paxalisib make it suitable for investigation in this patient group. Study enrollment is ongoing and expected to recruit approximately 25 patients.

Paxalisib in Pediatric Brain Cancer

Brain cancer is the most common malignancy of childhood and represents about one third of all childhood cancer deaths. The PI3K/AKT/mTOR pathway is frequently upregulated in pediatric cancers and therefore therapeutics that target those pathways could lead to well long-awaited regulatory approvals. DIPG is the most common of a group of childhood brain cancers known as diffuse midline gliomas (“DMGs”). The disease has no FDA approved drug treatments and average survival from diagnosis is approximately 10 months. Kazia recognizes the critical importance and immense unmet need and is exploring paxalisib in two common forms of childhood cancer-DIPGs and Advanced Childhood Cancer with PI3K/mTOR mutations.

St Jude Children’s Hospital Phase I Study in Diffuse Intrinsic Pontine Glioma (DIPG) (NCT03696355)

In February 2020, the company’s collaborators at St Jude Children’s Research Hospital in Memphis, TN completed recruitment to a phase I investigator- initiated clinical study of paxalisib in diffuse intrinsic pontine glioma (DIPG), a rare but highly aggressive childhood brain cancer with no approved pharmacological treatments. The St Jude study (NCT03696355) sought to establish a maximum tolerated dose (“MTD”) in the pediatric population before enrolling an expansion cohort to seek definitive signals of efficacy. In September 2019, the company announced that a pediatric MTD of 27 mg/m2 had been determined, which is

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approximately comparable to the doses used in adult clinical studies. The investigators reported interim data in an oral presentation at the SNO Annual Meeting in November 2020. The study met its primary objective and determined a maximum tolerated dose for pediatric use of 27 mg/m2. 27 patients were recruited, of whom 24 received at least one dose of paxalisib. The safety profile and pharmacokinetics were highly consistent with the adult data.

PNOC022 phase II Study in Diffuse Intrinsic Pontine Glioma (DIPG) (NCT05009992)

In December 2020, the company entered into a letter of intent with the Pacific Pediatric Neuro-Oncology Consortium (PNOC), an international consortium focused on the development of novel combination therapies, to execute an investigator-initiated phase II adaptive platform study of paxalisib in patients with DIPG and other DMGs, a group which collectively constitutes one of the most aggressive childhood cancers. The study will explore paxalisib in combination with ONC-201, a small-molecule investigational new drug which targets dopamine receptor D2 (DRD2), and which is manufactured by Oncoceutics, Inc, a wholly-owned subsidiary of Chimerix, Inc. Preliminary results were presented at Society of Neuro-Oncology 2023 Annual meeting on November 19, 2023. Sixty-eight patients with DMG were enrolled and the Median OS from time of diagnosis was 16.5 months (lower 95% confidence interval (“CI”) 11.6 months) with a median follow-up time of 9.9 months (95% CI: 8.5, 11.4). Most common grade 3 and above treatment-related adverse events were decreased neutrophil count (n=4); mucositis (n=3); and, colitis, drug reaction with eosinophilia and systemic symptoms, decreased lymphocyte count, hyperglycemia, and hypokalemia (n=2). On 27 June, 2024, Kazia announced that updated clinical data from the study will be presented at 21st International Symposium on Pediatric Neuro-Oncology. Highlights of the presentation included median overall survival of 13.2 months in Cohort 1 (newly diagnosed, enrolled pre-radiation n=33), 15.8 months in Cohort 2 (newly diagnosed, enrolled post-radiation n=69) and 8.8 months in Cohort 3 (relapsed patients, enrolled after progression n=30). Further analyses are ongoing by Pediatric Neuro-Oncology Consortium (“PNOC”) researchers and updates are expected in 2025.

OPTIMISE phase II study

Kazia entered into a collaboration with the Australian and New Zealand Children’s Haematology / Oncology Group in March 2023 for a phase II clinical study examining paxalisib as a targeted therapeutic in children with advanced solid tumours, including brain tumours. The study, named OPTIMISE, is the first Australian-led clinical trial to combine paxalisib and chemotherapy for children with PI3K pathway mutations in their tumours. Enrollment for this study is ongoing.

Paxalisib in Brain Metastases

Brain metastases occur when cancer cells spread from their original site to the brain, and treatment options are very limited. Brain metastases are a common complication of many tumours, but are particularly common in breast cancer, lung cancer, and melanoma and account for 67% to 89% of all cancers. Brain metastases are typically highly resistant to treatment and survival rates are generally low. Radiotherapy is a common treatment modality for brain metastases. Despite some efficacy, patients typically become resistant over time, and repeat courses of radiotherapy can be associated with significant neurological toxicity. Additionally, PI3K pathway mutations are common in brain metastasis and are frequently associated with a worse prognosis.

MSKCC phase I clinical study in Brain Metastases in Combination with Radiotherapy (NCT04192981)

Paxalisib is the subject of an ongoing phase I clinical study in patients with brain metastases and leptomeningeal metastases who harbor PI3K pathway mutations in combination with radiotherapy sponsored by Memorial Sloan Kettering Cancer Center in New York, NY. Encouraging safety and clinical activity from this study was presented by the lead investigator, Dr. Jonathan Yang in August 2022 at the ASCO/SNO CNS meeting held in Toronto, Canada. Interim data from the first stage of the study indicated that all 9 evaluable patients experienced complete or partial response, representing an overall response rate (ORR) of 100%, according to RANO-BM criteria. The patients comprised a range of primary tumors, with breast cancer the most common, representing one third of patients. The company announced that the phase I expansion cohort had reached an early conclusion based on positive safety data and positive clinical response findings observed to date. Preliminary data from the expansion cohort is anticipated by Q4 CY2024.

Alliance for Clinical Trials in Oncology Phase II Genomically-Guided Study in Brain Metastases (NCT03994796)

The Alliance for Clinical Trials in Oncology is sponsoring a phase II multi-drug study of multiple agents in the treatment of brain metastases from any primary tumour (NCT03994796) and substantially funded by the US National Cancer Institute. Three patient cohorts are enrolled in the paxalisib arm: breast cancer, lung cancer, and other tumors. The enrollment is ongoing for all cohorts including the expansion stage of the study in breast cancer brain metastases patients.

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Dana Farber Cancer Institute (DFCI) Phase II Study in HER2+ Breast Cancer Brain Metastases in Combination with Trastuzumab (NCT03765983)

Dr Jose Pablo Leone is the Principal Investigator for a phase II study in patients with HER2-positive breast cancer brain metastases, a population for which there are no approved pharmacological treatments, in which paxalisib is administered in combination with Herceptin (trastuzumab), sponsored by Dana-Farber Cancer Institute in Boston, MA. Study enrollment is complete and data is expected to be presented in CY2025.

Fast Track Designation

We received FTD by the FDA in July 2023 for paxalisib for the treatment of solid tumour brain metastases harboring PI3K pathway mutations in combination with radiation therapy, based on the promising clinical data from an interim analysis of the MSKCC phase 1 trial.

To be awarded FTD, drugs must generally be able to show some potential advantage over existing therapies, either in terms of safety or efficacy. The key benefits of FTD comprise enhanced access to FDA, with regular and more frequent opportunities for consultation and discussion. In addition, drugs with FTD may be eligible for Accelerated Approval, in which a new medicine is approved based on a surrogate endpoint, and Priority Review, in which the standard 12-month review process may be reduced to eight months. Drugs with FTD may also receive a ‘rolling review’ of their NDA submission, in which sections are submitted for review as they become available, potentially expediting the approval process.

EVT801

Kazia is also developing EVT801, a small-molecule selective inhibitor of VEGFR3. EVT801 was originally discovered by Sanofi SA and was licensed to Evotec SE as part of a broader transaction. Evotec conducted an extensive program of pre-clinical development, which showed compelling evidence of activity in broad range of animal models. The drug was licensed to Kazia in April 2021.

EVT801 Worldwide Exclusive License and Intellectual Property

The Company entered into an exclusive worldwide license agreement with Evotec SE in April 2021, under which Kazia has the right to develop and commercialize the asset in all indications. Evotec stands to receive up to €301 million in contingent milestone payments, and a royalty on net sales. Evotec has no right to direct the development of EVT801, no right of approval for Kazia to sub-license, and no right of first refusal. However, in the event of sub-licensing, Kazia may under certain circumstances share a portion of receipts from a sub-licensee with Evotec.

EVT801 is protected by granted or pending composition-of-matter patents in all key territories, with exclusivity generally through to the early 2030s.

For several decades, it has been clear that growing tumors require an extensive network of newly formed blood vessels and lymphatic vessels to satisfy their substantial nutrient requirements. Drugs which inhibit the formation of new blood vessels (angiogenesis inhibitors) have proven effective in a wide range of solid tumors, with Avastin (bevacizumab) being the best-known example of the class. However, the use of such drugs is limited by hypoxia- induced resistance mechanisms and, in the case of many small-molecule inhibitors, by toxicity. EVT801 was designed to respond to these challenges by selectively targeting lymphangiogenesis, the formation of new lymphatic vessels. Doing so, and with a high degree of selectivity, is expected to provide many of the same benefits as inhibition of angiogenesis, but without the attendant problems of resistance and toxicity.

In addition, drugs which target VEGF receptors have shown the potential to alter the population of immune cells within the tumour micro-environment, thereby potentially making ‘cold’ tumors more susceptible to immuno-oncology agents such as checkpoint inhibitors. We believe that pre-clinical evidence supports this hypothesis with EVT801 and may provide a second and almost entirely distinct mechanism of action through which the EVT801 may provide benefit to cancer patients.

Phase I Study in Advanced Solid Tumors (NCT05114668)

In November 2021, Kazia commenced recruitment to a phase I, first-in-human, multiple-ascending-dose, clinical trial of EVT801 in patients with advanced solid tumors which seeks to explore both of these mechanisms (inhibition of lymphangiogenesis and modulation of tumor immune micro-environment), The trial is being performed at two hospitals in France: Oncopole in Toulouse and Centre Léon Bérard in Lyons and will aim to recruit up to 60 patients with advanced cancer. In addition to the primary endpoints of safety and tolerability, the study is designed to include a rich array of biomarkers that will allow a deeper understanding of the drug’s pharmacology and may inform design of subsequent studies.

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On 1 May, 2024, Kazia announced that Stage 1 of the study was complete, and that the primary and secondary endpoints were achieved. A total of 32 patients were enrolled in the study with 26 patients treated across 6 dosing cohorts ranging from 50mg once daily to 500mg twice daily (BID). The MTD was identified as 500mg BID with 400mg BID being the recommended phase 2 dose when given as a monotherapy. Patients with eleven different cancer types (ex. colon, renal cell, pancreatic) were enrolled in the study, with advanced ovarian cancer being the most prevalent indication (11 patients). EVT801 was generally well tolerated across all doses with the majority of toxicities being mild to moderate and transient in nature. In addition, biomarkers have shown strong VEGFR3 expression in multiple indications, and we have observed encouraging clinical activity in High Grade Serous ovarian cancer patients with forty-six percent (46%) having stable disease or for at least three cycles and one patient had a partial response (-39% decrease) after two cycles of EVT801 therapy.

Over the course of FY 2024, interim results from the phase I study including clinical and biomarker EVT801 data have been presented at a number of global conferences, including the American Association for Cancer Research (“AACR”) and the European Society for Medical Oncology (“ESMO”). We anticipate providing additional EVT801 updates and presentations of data at future medical conferences including the AACR Ovarian Cancer Research Symposium in September 2024.

Significant changes in the state of affairs

There were no significant changes in the state of affairs of the Consolidated Entity during the financial year.

Anticipated milestones

We anticipate that during fiscal year 2025:

| • |  | Final data will be presented and reported from the phase II/III GBM AGILE clinical study of paxalisib in glioblastoma

| • |  | Additional results will be reported from the phase II PNOC clinical trial of paxalisib in combination with ONC201;

| • |  | Expansion cohort results will be reported from the phase I study of paxalisib in combination with radiotherapy in brain metastases;

| • |  | Discussion with regulatory authorities regarding next steps, (including potential approval pathways) for paxalisib in newly diagnosed unmethylated glioblastoma patients; and

| • |  | Pre-clinical results from our collaboration with OIMR Berghofer Medical Research Institute (“QIMR”) in advanced breast cancer animal models

R&D Pipeline

Paxalisib in solid tumours

Kazia’s collaboration with QIMR, one of Australia’s foremost cancer research centers, is currently exploring novel uses of paxalisib in solid tumours. The collaboration is based on research that identified an entirely separate effect of PI3K inhibition: as a modulator of the immune microenvironment within and around the tumour. Administration of PI3K inhibitors such as paxalisib, at doses and frequencies different to those conventionally used, may activate the immune system in the tumour, making it more susceptive to immunotherapy. This could therefore open up an important opportunity for paxalisib in combination with other drugs for the treatment of diseases such as breast cancer and lung cancer. The collaboration is ongoing and will build on initial research that has already led to the filing of a provisional patent in 2022, including the use of paxalisib as an immune modulator in the treatment of diseases such as breast cancer. On 12 September, 2024, Kazia announced that an agreement had been executed with QIMR Berghofer Medical Research Institute, one of Australia’s foremost cancer research centers, to obtain an exclusive license to certain intellectual property rights in relation to combination therapies consisting of PI3K inhibitor drugs, and one or more immunotherapy or PARP inhibitor drugs (PI3K combination).

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Broad Clinical Program Ongoing

Sponsor |  | Phase |  | Indication |  | Registration
PAXALISIB
Global Coalition for Adaptive Research |  | II / III |  | Glioblastoma |  | NCT03970447
Weill Cornell Medicine |  | II |  | Glioblastoma (with ketogenesis) |  | NCT05183204
Alliance for Clinical Trials in Oncology |  | II |  | Brain metastases |  | NCT03994796
Dana-Farber Cancer Institute |  | II |  | Breast cancer brain metastases (with Herceptin) |  | NCT03765983
Dana-Farber Cancer Institute |  | II |  | Primary CNS lymphoma |  | NCT04906096
University of Sydney |  | I/II |  | Grade 2/3 IDH-mutant adult gliomas |  | TBD
Pacific Pediatric Neuro-Oncology Consortium |  | II |  | DIPG (childhood brain cancer) |  | NCT05009992
Aus. & NZ Children’s Oncology Group |  | II |  | Advanced solid tumours in children |  | TBD
St Jude Children’s Research Hospital |  | I |  | DIPG |  | NCT03696355
Memorial Sloan Kettering Cancer Center |  | I |  | Brain metastases (with radiotherapy) |  | NCT04192981
EVT801
Kazia Therapeutics |  | I |  | Advanced solid tumours |  | NCT05114668

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Clinical Development Overview

IDH: Isocitrate dehydrogenase, DIPG: Diffuse Intrinsic Pontine Glioma, AT/RT: Atypical Teratoid Rhabdoid Tumor, CNS: central nervous system, TNBC: triple negative breast cancer, VEGFR3: vascular endothelial growth factor receptor 3

Patent Protection

The Company has an aggressive global Intellectual Property (“IP”) strategy to protect its key assets and we have partnered with a large Australian law firm to lodge patents that seek to provide protection for our assets. The patent strategy is adapted for each technology platform and the principle mode of protection is through the patenting procedure, seeking to obtain exclusive licenses for all its key inventions and drug pipeline. The overarching strategy in the IP portfolio is to cover the three critical corner stones of pharmaceutical patent: composition of matter (the breadth structures covered in the patent), method of manufacture (the chemical processes used to manufacture the compounds disclosed in the patent) and method of use. Patents are submitted initially as provisional applications and after 12 months’ progress through to a Patent Cooperation Treaty application.

We are continuing to expand our pre-clinical work on paxalisib and EVT801 through collaborations with research institutions. Where the research programs result in the generation of further patentable subject matter, the Company will pursue an aggressive patent filing strategy based on multiple jurisdictions with a focus on those member countries offering the most significant market opportunities for future development.

Regulatory requirements

Australian Regulatory Requirements

The Therapeutic Goods Act 1989 (“1989 Act”), sets out the legal requirements for the import, export, manufacture and supply of therapeutic goods, including medicines in Australia. The 1989 Act requires that all therapeutic goods imported into, supplied in, manufactured in or exported from Australia be included in the Australian Register of Therapeutic Goods (“ARTG”), unless specifically exempted or authorized under the 1989 Act.

Medicines with a higher level of risk (prescription medicines, most over-the-counter medicines) are evaluated by the Therapeutic Goods Administration (“TGA”) for quality, safety and efficacy before registration on the ARTG. Medicines with a lower risk (some over the counter medicines and most complementary medicines, including vitamins) are not individually assessed by the TGA prior to listing on the ARTG unless they are “assessed listed medicines” which are subject to pre-market TGA assessment of efficacy (but not quality and safety). Medicines included in the ARTG can be identified by the AUST R number (for registered medicines), AUST L number (for listed medicines) and AUST L(A) number (for assessed listed medicines) which appears on the packaging of the medicine.

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In order to include a product on the ARTG, a sponsoring company must make an application to the TGA. The application usually consists of a form accompanied by data in the Common Technical Document (CTD) format to support the quality, safety and efficacy of the product for its intended use and payment of a fee. Application details are available on the TGA website www.tga.gov.au.

The regulatory process for evaluation of prescription medicines consists of eight separate phases which are summarized below:

| 1. | Pre-submission, which involves lodgement of a pre-submission planning form that provides the TGA with necessary information on the scope and scale of an application for the purposes of arranging appropriate resourcing for the processing and evaluation of the application;

| 2. | Submission, which involves processing activities in preparation for application evaluation, including consideration of the application by the TGA against regulatory requirements;

| 3. | First round assessment, which involves consideration by the TGA of the data provided in the application and informal requests for information by the TGA;

| 4. | Consolidated section 31 request response, which involves the TGA sending a consolidated, formal information or document request to the applicant in relation to the application, and the applicant sending a response to the TGA (in CTD format);

| 5. | Second round assessment, which involves the TGA evaluators considering the response provided by the applicant to the section 31 request and completing the evaluation of the data;

| 6. | Expert advisory review, which involves the TGA obtaining independent advice (if required) on issues concerning the application from advisory groups such as the Advisory Committee on Medicines (the main advisory group for prescription medicines);

| 7. | Decision, which involves the TGA determining whether the application is to be approved (possibly modified or varied) or rejected and imposition of any conditions associated with approval for registration on the ARTG. Where any outstanding issues may affect the decision, this may involve further correspondence with the applicant before the decision is finalised; and

| 8. | Post-Decision, which involves completion of administrative and regulatory activities such as finalisation of outstanding payments and the ARTG entry.

During the above process, applicants will be able to comment on evaluation reports to highlight any errors of fact or major omissions and comment on the request for advice from the independent Advisory Committee on Medicines when such advice is sought.

In relation to Phase 2 (“Submission”), above, the TGA must notify the applicant of an acceptance or rejection of the application within 40 working days following receipt of an application, although this usually occurs within 15 or 21 calendar days. Once accepted for evaluation, the TGA has 255 working days to complete its evaluation and make a decision on the registration of the product (excluding any time spent waiting for the applicant to respond to the TGA’s questions).

The TGA also has a system of priority evaluation for products that meet certain criteria, including where:

| • |  | the medicine is a new prescription medicine;

| • |  | an indication of the medicine is the treatment, prevention or diagnosis of a life-threatening or seriously debilitating condition;

| • |  | there are no therapeutic goods that are intended to treat, prevent or diagnose the condition in the ARTG; and

| • |  | there is substantial evidence demonstrating that the medicine provides a major therapeutic advance.

U.S. Regulatory Requirements

The FDA regulates and imposes substantial requirements upon the research, development, pre-clinical and clinical testing, labelling, manufacture, quality control, storage, approval, advertising, promotion, marketing, distribution, import and export of pharmaceutical products including drugs and biologics, as well as significant reporting and record-keeping obligations. State governments may also impose obligations in some of these areas.

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In the United States, pharmaceutical products are primarily regulated by the FDA under the Federal Food, Drug, and Cosmetic Act (“FDCA”) and its implementing regulations, and in the case of biologics, the Public Health Service Act and its implementing regulations. The Company believes that the FDA will regulate its products as drugs. The process required by the FDA before drugs may be marketed in the United States generally involves the following:

| • |  | pre-clinical laboratory evaluations, including formulation and stability testing, and animal tests performed under the FDA’s Good Laboratory Practices regulations to assess pharmacological activity and toxicity potential;

| • |  | submission and review of an IND Application, including results of pre-clinical studies, clinical experience (if any), manufacturing information, and protocols for clinical trials, which must become effective before clinical trials may begin in the United States;

| • |  | obtaining approval of Institutional Review Boards (“IRBs”), to administer the products to human subjects in clinical trials;

| • |  | adequate and well-controlled human clinical trials to establish the safety and efficacy of the product for the product’s intended use;

| • |  | development of manufacturing processes which conform to FDA current Good Manufacturing Practices (“GMPs”), as confirmed by FDA inspection;

| • |  | submission of results for pre-clinical and clinical studies, and chemistry, manufacture and control information on the product to the FDA in a New Drug Approval (“NDA”) Application; and

| • |  | FDA review and approval of an NDA, prior to any commercial sale, promotion or shipment of a product.

The testing and approval process requires substantial time, effort, and financial resources, and the Company cannot be certain that any approval will be granted on a timely basis, if at all.

The results of the pre-clinical studies, clinical experience together with initial specified manufacturing information, the proposed clinical trial protocol, and information about the participating investigators are submitted to the FDA as part of an IND, which must become effective before the Company may begin human clinical trials in the U.S. Additionally, an independent IRB must review and approve each study protocol and oversee conduct of the trial. An IND becomes effective 30 days after receipt by the FDA, unless the FDA, within the 30-day period, raises concerns or questions about the conduct of the trials as outlined in the IND and imposes a clinical hold. If the FDA imposes a clinical hold, the IND sponsor must resolve the FDA’s concerns before clinical trials can begin. Pre-clinical tests and studies can take several years to complete, and there is no guarantee that an IND submitted, based on such tests and studies, will become effective within any specific time period, if at all.

Human clinical trials are typically conducted in three sequential phases that may overlap, which are:

| • |  | Phase I: The drug is initially introduced into healthy human subjects or patients and tested for safety and dosage tolerance. For oncology medicines, patients with the target disease are usually enrolled rather than healthy patients. Absorption, metabolism, distribution, and excretion testing, among other tests, are generally performed at this stage. These studies may also provide early evidence of effectiveness. The maximum tolerated dose of the drug may be calculated from phase I studies;

| • |  | Phase II: The drug is studied in controlled, exploratory therapeutic trials in a limited number of subjects with the disease or medical condition for which the new drug is intended to be used in order to identify possible adverse effects and safety risks, to determine the preliminary or potential efficacy of the product for specific targeted diseases or medical conditions, and to determine dosage tolerance and the optimal effective dose; and

| • |  | Phase III: While phase II studies help demonstrate that a specific dosage range of the drug may be effective and the drug has an acceptable safety profile, controlled, large-scale therapeutic, phase III trials are undertaken at multiple study sites to demonstrate clinical efficacy and to further test for safety in an expanded patient population. These studies are used to evaluate the overall benefit - risk relationship of the drug and provide a basis for physician labelling.

The Company cannot be certain that it will successfully complete phase I, phase II or phase III testing of its products within any specific time period, if at all. Furthermore, the FDA, the IRB or the Company may suspend or terminate clinical trials at any time on various grounds, including a finding that the subjects or patients are being exposed to an unacceptable health risk.

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Results of pre-clinical studies and clinical trials, as well as detailed information about the manufacturing process, quality control methods, and product composition, among other things, are submitted to the FDA as part of an NDA seeking approval to market and commercially distribute the product on the basis of a determination that the product is safe and effective for its intended use. Before approving an NDA, the FDA will inspect the facilities at which the product is manufactured and will not approve the product unless GMP compliance is satisfactory. If applicable regulatory criteria are not satisfied, the FDA may deny the NDA or require additional testing or information. As a condition of approval, the FDA also may require post-marketing testing or surveillance to monitor the product’s safety or efficacy. Even after an NDA is approved, the FDA may impose additional obligations or restrictions (such as labelling changes), or even suspend or withdraw a product approval on the basis of data that arise after the product reaches the market, or if compliance with regulatory standards is not maintained. The Company cannot be certain that the FDA on a timely basis, if at all will approve any NDA it submits. Also, any such approval may limit the indicated uses for which the product may be marketed. Any refusal to approve, delay in approval, suspension or withdrawal of approval, or restrictions on indicated uses could have a material adverse impact on the Company’s business prospects.

A user fee, pursuant to the requirements of the PDUFA, and its amendments, applies to NDAs, unless exempted. The FDA adjusts the PDUFA user fees on an annual basis. PDUFA also imposes an annual product fee for prescription drugs and biologics, and an annual establishment fee on facilities used to manufacture prescription drugs and biologics. A written request can be submitted for a waiver under certain circumstances. Waivers may be possible for the application fee for the first human drug application that is filed by a small business, as defined by the FDCA, but there are no small business waivers for product or establishment fees. Waivers may also be possible for one or more fees, upon written request, when a waiver or reduction is necessary to protect the public health, the user fees would present a significant barrier to innovation, or the fees are anticipated to exceed the present or future costs incurred by FDA. Applications for products designated as orphan drugs are not subject to the application fee unless the application includes an indication for other than a rare disease or condition. The Company is not at the stage of development with its products where it is subject to these fees, but they are significant expenditures that may be incurred in the future and must be paid at the time of application submissions to FDA, as applicable.

Satisfaction of FDA requirements for product approval typically takes several years. The actual time required varies substantially, based upon the type, complexity, and novelty of the pharmaceutical product, among other things. Government regulation imposes costly and time-consuming requirements and restrictions throughout the product life cycle and may delay product marketing for a considerable period of time, limit product marketing, or prevent marketing altogether. Success in pre-clinical or early stage clinical trials does not ensure success in later stage clinical trials. Data obtained from pre-clinical and clinical activities are not always conclusive and may be susceptible to varying interpretations that could delay, limit, or prevent marketing approval. Even if a product receives marketing approval, the approval is limited to specific clinical indications. Further, even after marketing approval is obtained, the discovery of previously unknown problems with a product may result in restrictions on the product or even complete withdrawal of the product from the market.

After product approval, there are continuing significant regulatory requirements imposed by the FDA, including record-keeping requirements, obligations to report adverse events in patients using the products, and restrictions on advertising and promotional activities. Quality control and manufacturing procedures must continue to conform to GMPs, and the FDA periodically inspects facilities to assess GMP compliance. Additionally, post-approval changes in ingredient composition, manufacturing processes or facilities, product labelling, or other areas may require submission of an NDA Supplement to the FDA for review and approval. New indications will require additional clinical studies and submission of an NDA Supplement. Failure to comply with FDA regulatory requirements may result in an enforcement action by the FDA, including warning letters, product recalls, suspension or revocation of product approval, seizure of product to prevent distribution, impositions of injunctions prohibiting product manufacture or distribution, and civil and criminal penalties. Maintaining compliance is costly and time-consuming. The Company cannot be certain that it, or its present or future suppliers or third-party manufacturers, will be able to comply with all FDA regulatory requirements, and potential consequences of noncompliance could have a material adverse impact on its business prospects.

The FDA’s policies may change, and additional governmental regulations may be enacted that could delay, limit, or prevent regulatory approval of the Company’s products or affect its ability to manufacture, market, or distribute its products after approval. Moreover, increased attention to the containment of healthcare costs in the U.S. and in foreign markets could result in new government regulations that could have a material adverse effect on the business. The Company’s failure to obtain coverage, an adequate level of reimbursement, or acceptable prices for future products could diminish any revenues the Company may be able to generate. The Company’s ability to commercialize future products will depend in part on the extent to which coverage and reimbursement for the products will be available from government and health administration authorities, private health insurers, and other third-party payers. EU member states and U.S. government and other third-party payers increasingly are attempting to contain healthcare costs by consideration of new laws and regulations limiting both coverage and the level of reimbursement for new drugs. The Company cannot predict the likelihood, nature or extent of adverse governmental regulation that might arise from future legislative or administrative action, either in the U.S. or abroad.

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The Company’s activities may also be subject to state laws and regulations that affect its ability to develop and sell products. The Company is also subject to numerous federal, state, and local laws relating to such matters as safe working conditions, clinical, laboratory, and manufacturing practices, environmental protection, fire hazard control, and disposal of hazardous or potentially hazardous substances. The Company may incur significant costs to comply with such laws and regulations now or in the future, and the failure to comply may have a material adverse impact on the Company.

The FDA provides programs intended to facilitate and expedite development and review of new products that are intended to address an unmet medical need in the treatment of a serious or life-threatening disease or condition. These programs are referred to as fast track designation, breakthrough therapy designation and priority review designation. These designations are not mutually exclusive, and a product candidate may qualify for one or more of these programs. While these programs are intended to expedite product development and approval, they do not alter the standards for FDA approval. The FDA may designate a product for fast-track designation if it is intended, whether alone or in combination with one or more other products, for the treatment of a serious or life-threatening disease or condition, and it demonstrates the potential to address unmet medical needs for such a disease or condition. For products with fast-track designation, sponsors may have more frequent interactions with the FDA, the product is potentially eligible for accelerated approval and priority review, if relevant criteria are met. A product may be designated as a breakthrough therapy if it is intended, either alone or in combination with one or more other products, to treat a serious or life-threatening disease or condition and preliminary clinical evidence indicates that the product may demonstrate substantial improvement over existing therapies on one or more clinically significant endpoints, such as substantial treatment effects observed early in clinical development. The FDA may take certain actions with respect to breakthrough therapies, including holding meetings with the sponsor throughout the development process; providing timely advice to the product sponsor regarding development and approval; involving more senior staff managers in the review process; assigning a cross-disciplinary lead for the review team; and taking other steps to design the clinical trials in an efficient manner. The FDA may designate a product for priority review if it is a product that treats a serious condition and, if approved, would provide a significant improvement in safety or effectiveness when compared with other available therapies. Additionally, drug approval under the accelerated approval pathway may be based on evidence of clinical effect on a surrogate endpoint or intermediate clinical endpoint that is reasonably likely to predict clinical benefit. A post-marketing clinical study will be required to verify clinical benefit, and other restrictions to assure safe use may be imposed.

Under the Drug Price Competition and Patent Term Restoration Act of 1984, a sponsor may obtain marketing exclusivity for a period of time following FDA approval of certain drug applications, regardless of patent status, if the drug is a new chemical entity or if new clinical studies were required to support the marketing application for the drug. This marketing exclusivity prevents a third party from obtaining FDA approval for an identical or nearly identical drug under an Abbreviated New Drug Application. The statute also allows a patent owner to obtain an extension of applicable patent terms for a period equal to one-half the period of time elapsed between the filing of an IND and the filing of the corresponding NDA plus the period of time between the filing of the NDA and FDA approval, with reductions taken for any time an applicant did not act with due diligence. There is a five-year maximum patent extension and a maximum of 14 years protection from product approval. The Company cannot be certain that it will be able to take advantage of either the patent term extension or marketing exclusivity provisions of these laws.

European Union Regulatory Requirements

Outside the United States, the Company’s ability to market its products will also be contingent upon receiving marketing authorizations from the appropriate regulatory authorities and compliance with applicable post-approval regulatory requirements. Although the specific requirements and restrictions vary from country to country, as a general matter, foreign regulatory systems include risks similar to those associated with FDA regulation, described above. In the EU, a marketing authorization application may be submitted either under a centralized or a national procedure. Under the centralized procedure, a single application to the European Medicines Agency (“EMA”) leads to an approval granted by the European Commission that permits the marketing of the product throughout the EU and in the additional member states of the European Economic Area (Norway, Iceland and Liechtenstein). The centralized procedure is mandatory for specific products, including for medicines produced by certain biotechnological processes, products designated as orphan medicinal products, advanced therapy medicinal products (gene therapy, somatic cell therapy and tissue-engineered products) and products with a new active substance indicated for the treatment of certain diseases, including products for the treatment of HIV, AIDS, cancer, diabetes, neurodegenerative diseases, auto-immune and other immune dysfunctions and viral diseases. The centralized procedure is optional for any other products containing new active substances not authorized in the EU or for products which constitute a significant therapeutic, scientific, or technical innovation or for which a centralized authorization is in the interests of patients at EU level. Under the centralized procedure the maximum timeframe for the evaluation of a marketing authorization application by the EMA is 210 days, excluding clock stops, when additional written or oral information is to

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be provided by the applicant in response to questions asked by the EMA’s Committee for Medicinal Products for Human Use (“CHMP”). Clock stops may extend the timeframe of evaluation of a marketing authorization application considerably beyond 210 days. Where the CHMP gives a positive opinion, it provides the opinion together with supporting documentation to the European Commission, who make the final decision to grant a marketing authorization, which is issued within 67 days of receipt of the EMA’s recommendation. Accelerated assessment might be granted by the CHMP in exceptional cases, when a medicinal product is expected to be of major public health interest, particularly from the point of view of therapeutic innovation. The timeframe for the evaluation of a marketing authorization application under the accelerated assessment procedure is 150 days, excluding clock stops, but it is possible that the CHMP may revert to the standard time limit for the centralized procedure if it determines that the application is no longer appropriate to conduct an accelerated assessment.

As with FDA approval, the Company may not be able to secure regulatory approvals in the EU in a timely manner, if at all. Additionally, as in the U.S., post-approval regulatory requirements, such as those regarding product manufacture, marketing, or distribution, would apply to any product that is approved in the EU, and failure to comply with such obligations could have a material adverse effect on the Company’s ability to successfully commercialize any product.

The conduct of clinical trials in the EU is governed by the Clinical Trials Regulation (EU) No 536/2014 (“CTR”), which replaced the previous Clinical Trials Directive 2001/20/EC on 31 January, 2022. No clinical trial may be commenced in the EU without a clinical trial authorization from the applicable national competent authorities and favourable ethics approval. Under the CTR, a single application can be made through the Clinical Trials Information System for authorization of a clinical trial in up to 30 EU/ European Economic Area countries at the same time and with a single set of documentation.

The assessment of applications for clinical trials is divided into two parts (Part I contains scientific and medicinal product documentation and Part II contains the national and patient-level documentation). Part I is assessed by a coordinated review by the competent authorities of all EU member states in which an application for authorization of a clinical trial has been submitted (Member States Concerned) of a draft report prepared by a Reference Member State. Part II is assessed separately by each Member State Concerned. The role of the relevant ethics committees in the assessment procedure continues to be governed by the national law of the Member State Concerned, however overall related timelines are defined by the CTR. The new CTR also provides for simplified reporting procedures for clinical trial sponsors.

Environmental, social and governance (ESG) report

Environmental

The Consolidated Entity is not currently subject to any significant or unusual environmental regulation under Australian Commonwealth or State law. We are considering ways in which environmental impacts can be monitored however we do not foresee a material impact.

Sustainability

Kazia’s head office is located in a sustainable carbon neutral commercial precinct. The serviced office is located in a building with a five star NABERS energy rating.

Climate Change

Kazia is mindful of its impact on the environment and strives to reduce its carbon footprint. The Kazia business model is based on outsourcing, and we are working with major partners who are focused on reducing climate change and enhancing climate protection.

Society

Community Contribution

Compassionate Use Program

In rare circumstances, after careful discussion with the treating clinician, Kazia is sometimes able to provide its drug candidates for compassionate use on an individual named patient basis.

Our compassionate use program has treated over 40 patients in 7 countries since its inception in 2018.

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Countries we treat compassionate patients in: Australia, USA, Israel, Spain, Switzerland, England and Ireland

Social and Governance

Social and governance matters cover a vast range of potential issues including responsible business policies. Our policies set out our commitment to high social standards.

The following policies are in place and available on our website:

| • |  | Anti-Corruption Compliance

| • |  | Continuous Disclosure

| • |  | Corporate Governance

| • |  | Expanded Access

| • |  | Shareholder Communications

| • |  | Whistleblower

| • |  | FDA review and approval of an NDA, prior to any commercial sale, promotion or shipment of a product.

Employees

The Consolidated Entity aims to ensure that it has a safe operating environment with an inclusive and diverse culture and the best talent and skills for our future success. The following employee policies are in place:

| • |  | Code of Business Conduct & Ethics

| • |  | Recruitment and retention

| • |  | Inclusion and diversity

| • |  | Parents returning to work

| • |  | Education and training

| • |  | Employee Share Option Plan

| • |  | Health and safety

| • |  | Whistleblowing

| • |  | Equal Employment Opportunity and Diversity

| • |  | Harassment and Discrimination

| • |  | Anti-corruption and anti-bribery policies

| • |  | Public disclosures

| • |  | Securities trading

| • |  | Scientific integrity

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Product and Corporate Developments during Fiscal Year 2024

The Company continued to pursue its strategy of focusing resources on clinical programs, being specifically those most likely to provide a return to shareholders.

Paxalisib is involved in ten clinical trials, all being conducted by world renowned research organizations and principally funded by parties other than the Company, giving us multiple opportunities to realise value from this product candidate.

EVT801’s phase I clinical trial continues and we believe that we are on track to have initial phase I data in the Q4 CY2023.

At-The-Market (ATM) Facility

Kazia established an ‘at-the-market’ equity program (the “ATM facility”) with Oppenheimer & Co. Inc. (“Oppenheimer”), as sales agent, in April 2022. Under the ATM facility, Kazia may offer and sell through Oppenheimer up to an aggregate amount of US$50 million of its ordinary shares, in the form of ADSs. During the fiscal year ended 30 June 2024, Kazia sold an aggregate amount of US$1,656,016 (2023 US$4,203,221) of ADSs under the ATM facility. The ATM facility allows Kazia to raise capital dynamically in the open market, with no discount, no warrant coverage, and modest banking fees, allowing it to fund operations with minimal dilution to existing shareholders.

Voluntary Delisting from ASX

On 11 October 2023 Kazia announced that it submitted a formal application to the ASX to be removed from the official list of the ASX (the “Official List”) in accordance with ASX Listing Rule 17.11. On 15 November 2023, Kazia was removed from the Official List and its ordinary shares ceased to be traded on the ASX.

Equity Line of Credit

On 19 April 2024, Kazia entered into a purchase agreement (the “Purchase Agreement”) with Alumni Capital LP (“Alumni Capital”). Pursuant to the Purchase Agreement, the Company may sell to Alumni Capital up to an aggregate of $15,000,000, of ADSs from time to time during the term of the Purchase Agreement. During the fiscal year ended 30 June 2024, Kazia sold an aggregate amount of US$517,302 (A$776,147) of ADSs under the Purchase Agreement.

ADS Ratio Change

On 15 October 2024, Kazia announced that it planned to effect an ADS ratio change to change the ratio of ADSs to ordinary shares from one ADS to ten ordinary shares to the new ratio of one ADS to one-hundred ordinary shares. The ADS ratio change will have the same effect as a one-for-ten reverse ADS split for Kazia’s ADS holders. There will be no change to Kazia’s underlying ordinary shares, and no ordinary shares will be issued or cancelled in connection with the ADS ratio change. The ADS ratio change became effective on 28 October 2024.

C. Organizational structure

Kazia Therapeutics Limited is incorporated in Australia and has the following wholly-owned subsidiaries:

Name |  | Country of incorporation
Kazia Laboratories Pty Ltd |  | Australia
Kazia Research Pty Ltd |  | Australia
Kazia Therapeutics Inc. |  | United States (Delaware)
Glioblast Pty Ltd |  | Australia

D. Property, plant and equipment

During fiscal year 2024, the Company continued to work out of a serviced office in Sydney that is subject to a renewable one-year workspace license agreement. In April 2022 an office membership agreement was signed with Deerfield Management for one year in The Cure, Deerfield’s innovation campus at 345 Park Avenue South, New York, NY, and was extended for an additional 12 months until April 2025.

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Item 4A. | Unresolved Staff Comments

None.

Item 5. | Operating and Financial Review and Prospects

Critical accounting policies

We prepare our consolidated financial statements in accordance with International Financial Reporting Standards (IFRS) as issued by the International Accounting Standards Board (IASB). As such, we are required to make certain estimates, judgments, and assumptions that management believes are reasonable based upon the information available. These estimates, judgments and assumptions affect the reported amounts of assets and liabilities at the date of the consolidated financial statements and the reported amounts of revenues and expenses during the periods presented. The critical accounting policies are summarized in Item 18. “Financial Statements-Note 3 - Critical accounting judgements, estimates and assumptions”.

The following discussion and analysis should be read in conjunction with Item 18. “Financial Statements” included below. Operating results are not necessarily indicative of results that may occur in future periods. This discussion and analysis contains forward-looking statements that involve risks, uncertainties and assumptions. The actual results may differ materially from those anticipated in the forward-looking statements as a result of many factors including, but not limited to, those set forth under “Forward-Looking Statements” and “Risk Factors” in Item 3 “Key Information” included above in this Annual Report on Form 20-F. All forward-looking statements included in this document are based on the information available to the Company on the date of this document and the Company assumes no obligation to update any forward-looking statements contained in this Annual Report on Form 20-F.

A. Operating results

The following discussion relates to our consolidated results of operations, financial condition and capital resources. You should read this discussion in conjunction with our consolidated financial statements and the notes thereto contained elsewhere in this report.

The following tables provide a summary of Revenue, Finance income and Other income for the past three fiscal years:

|  | For the fiscal year ended 30 June, |
|  | 2024 |  |  | 2023 |  |  | 2022 |
|  | A$’000 |  |  | A$’000 |  |  | A$’000 |
Revenue |  |  | 2,308 |  |  |  | — |  |  |  | — |
Finance income |  |  | 12 |  |  |  | 22 |  |  |  | 2 |
Other income: |  |  |  |  |  |  |  |  |  |  |  |
Research and development rebate |  |  | 173 |  |  |  | — |  |  |  | — |
Bad debt recovery |  |  | — |  |  |  | — |  |  |  | 15 |
Other sundry income |  |  | — |  |  |  | 1 |  |  |  | — |
Subsidies and grants |  |  | — |  |  |  | — |  |  |  | 10 |
Total Revenue, Finance and Other income |  |  | 2,493 |  |  |  | 23 |  |  |  | 27 |

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Fiscal year 2024 compared to fiscal year 2023 and fiscal year 2023 compared to fiscal year 2022

Revenue, finance income and other income

In fiscal year 2024, the Company generated revenue A$2.3 million of from contracts with customers was the result of up-front license fees received from partnering transactions pertaining to the out-license agreements entered into for one of the Company’s assets, paxalisib. During fiscal years 2023 and 2022, the Company did not generate any revenue from contracts with customers.

The Company earns interest income derived from interest bearing bank accounts, which is directly linked with the amounts held on deposit. The amount of finance income earned increased as a result of increased cash balances as well as higher interest rates in effect during the year.

The Company recognized research and development rebate in the fiscal years 2024 of A$173 thousand. The Company did not recognize any research and development rebate in 2023 and 2022. We anticipate applying for the rebate in future fiscal years as the Company advances paxalisib development in Australia.

Expenses

Research and development expenses increased from A$15.6 million in fiscal year 2023 to A$17.4 million in fiscal year 2024 (12%). The increase was mainly a result of transaction fee expenses of A$6.0 million in fiscal year 2024 partially offset by less clinical expenses relating to paxalisib and lower personnel costs. Research and development expenses decreased from A$20.2 million in fiscal year 2022 to A$15.6 million in fiscal year 2023 (-23%). The decrease was mainly a result of lower R&D expense for paxalisib, offset by higher expenses for EVT-801 and a full year of salary and benefit expenses were recognized for the US based scientific and clinical staff hired in fiscal year 2022.

General and administrative costs increased from A$8.6 million in fiscal year 2023 to A$13.5 million in fiscal year 2024 (58%), due to increased costs related to the issuance of certain warrants to service providers, audit and NASDAQ fees, offset by lower directors and officers liability and business insurance costs, and a partial year of salary and benefits for the US based Chief Financial Officer. General and administrative costs increased from A$5.1 million (restated) in fiscal year 2022 to A$8.6 million in fiscal year 2023 (68%), due to increased directors and officers liability and business insurance costs, a full year of salary and benefits for the US based Chief Financial Officer, a full year of US office rent and the termination payment for former CEO James Garner.

Net loss after income tax benefit

The Company’s loss after income tax benefit was A$26.8 million in fiscal year 2024 compared to A$20.5 million in fiscal year 2023. The change was mainly a result of the additional R&D expenditures and a dramatic increase in NASDAQ, legal and audit fees. Offset by lower personnel expenses, D&O insurance and public relation costs.

The Company’s loss after income tax benefit was A$20.5 million in fiscal year 2023 compared to A$25.0 million (restated) in fiscal year 2022. The change was mainly a result of the reduced R&D expenditures a reduction in the expenditures incurred for the Company’s lead asset, paxalisib’s continuing participation in the registrational GCAR GBM AGILE trial as paxalisib arm did not meet pre-defined criteria for continuing to a second stage of the trial. Funds were also spent on the expenditures incurred for the continuing EVT801 Phase I trial including A$2.1M for manufacture of EVT-801.

B. Liquidity and capital resources

We have incurred cumulative losses and negative cash flows from operations since our inception and, as of 30 June 2024, we had accumulated losses of A$115.1 million. We anticipate that we will continue to incur losses for at least the next several years. We expect that our research and development expenditure will continue to increase and, as a result, we will need additional capital to fund our operations, which we may raise through a combination of equity offerings, other third-party funding, and other collaborations, strategic alliances and licensing arrangements.

There is a premium funding facility in place in fiscal year 2024, 2023, and 2022 for the insurance program.

As of 30 June 2024, we had cash and cash equivalents of A$1.7 million held in both Australian dollars and U.S. dollars. Cash in excess of immediate requirements is invested in accordance with our investment policy primarily with a view to liquidity and capital preservation. Currently, our cash and cash equivalents are held in bank accounts with approximately 83.7% of funds being held in U.S. dollars.

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Going Concern

We expect to consume cash and incur operating losses for the foreseeable future as the Company continues developing its oncology drug candidates. The impact on cash resources and results from operations will vary with the extent and timing of the future clinical trial programs. The consolidated financial statements have been prepared on a going concern basis, which contemplates continuity of normal activities and realization of assets and settlement of liabilities in the normal course of business. As is often the case with drug development companies, the Company’s ability to continue its development activities as a going concern is dependent upon deriving sufficient cash from investors, from licensing and partnering activities and from other sources of revenue such as grant funding. We may be required to delay, scale-back, or eliminate certain of our activities and other aspects of our operations until such time as we are successful in securing additional funding. We are exploring various dilutive and non-dilutive sources of funding, including equity and debt financings, strategic alliances, business development and other sources. Our future success is dependent upon our ability to obtain additional funding. There can be no assurance, however, that we will be successful in obtaining such funding in sufficient amounts, on terms acceptable to us, or at all. Furthermore, under General Instruction I.B.5 to Form F-3 (the “Baby Shelf Rule”) the amount of funds we can raise through primary public offerings of securities in any 12-month period using our registration statement on Form F-3 is limited to one-third of the aggregate market value of the ordinary shares held by non-affiliates of our company, which limitation may change over time based on our stock price, number of ordinary shares outstanding and the percentage of ordinary shares held by non-affiliates. We therefore are limited by the Baby Shelf Rule as of the filing of this Annual Report until such time as our non-affiliate public float exceeds $75 million. There is substantial doubt about our ability to continue as a going concern within one year after the date that the consolidated financial statements for the fiscal year ended 30 June 2024 are issued.

Cash flows

The following table set forth the sources and uses of cash for the past three fiscal years:

(in A$ thousands) |  | 2024 |  |  | 2023 |  |  | 2022 |
Net cash used in operating activities |  | $ | (9,581 | ) |  | $ | (15,156 | ) |  | $ | (22,762 | )
Net cash used in investing activities |  | $ | — |  |  | $ | — |  |  | $ | (2,365 | )
Net cash provided by financing activities |  | $ | 5,985 |  |  | $ | 12,972 |  |  | $ | 3,726 |

Operating activities. Net cash used in operating activities for the three fiscal years primarily represents net outflows for the cost of our R&D programs and general and administrative costs of running the business. This amount is heavily impacted by the cost of our clinical programs, as well as cost containment measures adopted to manage the general and administrative costs of the business.

Investing activities. Net cash from investing activities in fiscal year 2022 represents the payment of a development milestone for EVT801.

Financing activities. Net cash from the financing activities in fiscal year 2024 arose as a result of the placement of warrants and the sale of ordinary shares in the form of ADSs, using our ATM facility. Net cash from financing activities in fiscal years 2023 arose as a result of professional placements of the Company’s ordinary shares to institutional investors in certain countries as well as Share Purchase Plans to shareholders in Australia. In addition, net cash from financing activities in fiscal years 2024, 2023, and 2022 was the result of the funds received from our sale of ordinary shares using our ATM facility.

As of 30 June 2024, the Company did not hold any derivative financial instruments for managing its foreign currency; however, the Company may from time to time enter into hedging arrangements where circumstances are deemed appropriate.

The Company believes that its future ability to fund its operations will depend on deriving sufficient cash from investors through successful capital raises, from licensing and partnering activities, and government grants.

The Company had no commitments for capital expenditures or material contractual obligations at the end of fiscal year 2024. The Company continuously pursues opportunities for non-dilutive funding such as grant applications.

The Company cannot provide assurance that it or its subsidiaries will be able to raise the funds necessary to complete the planned clinical trial programs or find appropriate collaboration or licensing opportunities.

The Company does not have any off-balance sheet arrangements.

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Financing activities

Equity issues

The Company has historically financed its operations primarily from issuing equity capital.

During fiscal year 2023 the Company issued 89,273,738 ordinary shares. The details of those share issues are as follows:

| • |  | In July 2022, the Company issued 573,370 shares under our ATM facility raising A$407,201 before transaction costs.

| • |  | In August 2022, the Company issued 10,307,910 shares under our ATM facility raising A$3,268,936 before transaction costs.

| • |  | In September 2022, the Company issued 679,380 shares under our ATM facility raising A$150,164 before transaction costs.

| • |  | In September 2022, the Company issued 60,000 to the Scientific Advisory Board at A$12,600 before transaction costs

| • |  | In October 2022, the Company issued 13,032,940 shares under our ATM facility raising A$2,425,085 before transaction costs.

| • |  | In January 2023, the Company issued 20,000 shares under our ATM facility raising A$2,761 before transaction costs.

| • |  | In January 2023, the Company issued 25,387,018 shares in a professional and sophisticated investors placement raising A$2,792,572 before transaction costs.

| • |  | In February 2023, the Company issued 15,522,075 shares in a professional and sophisticated investors placement raising A$1,707,428 before transaction costs.

| • |  | In March 2023, the Company issued 23,691,045 shares in a share placement plan to existing eligible shareholders raising A$2,606,000 before transaction costs.

During fiscal year 2024 the Company issued 104,821,670 ordinary shares. The details of those share issues are as follows:

| • |  | In July 2023, the Company issued 8,148,140 shares under our ATM facility raising A$1,512,523 before transaction costs.

| • |  | In July 2023, the Company issued 157,120 shares under our ATM facility raising A$25,877 before transaction costs.

| • |  | In August 2023, the Company issued 15,000 shares under our ATM facility raising A$2,519 before transaction costs.

| • |  | In November 2023, the Company issued 1,066,070 shares under our ATM facility raising A$107,268 before transaction costs.

| • |  | In December 2023, we issued 26,200,000 ordinary shares in the form registered direct offering raising A$1,796,867 before transaction costs.

| • |  | In February 2024, the Company issued 25,910 shares under our ATM facility raising A$1,207 before transaction costs.

| • |  | In February 2024, the Company issued 319,650 shares under our ATM facility raising A$14,834 before transaction costs.

| • |  | In February 2024, the Company issued 2,195,980 shares under our ATM facility raising A$102,825 before transaction costs.

| • |  | In February 2024, the Company issued 205,260 shares under our ATM facility raising A$12,597 before transaction costs.

| • |  | In February 2024, the Company issued 8,626,580 shares under our ATM facility raising A$513,584 before transaction costs.

| • |  | In February 2024, the Company issued 18,244,450 shares in connection with the exercise of a warrants raising A$892,381 before transaction costs.

| • |  | In February 2024, the Company issued 316,540 shares under our ATM facility raising A$14,584 before transaction costs.

| • |  | In February 2024, the Company issued 304,860 shares under our ATM facility raising A$14,147 before transaction costs.

| • |  | In February 2024, the Company issued 250,000 shares under our ATM facility raising A$11,502 before transaction costs.

| • |  | In May 2024, the Company issued 2,112,560 shares under our ATM facility raising A$100,961 before transaction costs.

| • |  | In May 2024, the Company issued 375,410 shares under our ATM facility raising A$17,147 before transaction costs.

| • |  | In May 2024, the Company issued 288,900 shares under our ATM facility raising A$13,544 before transaction costs.

| • |  | In May 2024, the Company issued 790,100 shares under our ATM facility raising A$36,024 before transaction costs.

| • |  | In May 2024, the Company issued 20,000 shares under our ATM facility raising A$910 before transaction costs.

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| • |  | In May 2024, the Company issued 242,170 shares under our ATM facility raising A$10,891 before transaction costs.

| • |  | In June 2024, the Company issued 5,916,970 ordinary shares represented by 59,170 ADSs as repayment of a promissory note.

| • |  | In June 2024, the Company issued 29,000,000 shares under a private ELOC placement raising A$776,264 before transaction costs.

In fiscal year 2024, the Company held a significant proportion of its cash balances in U.S. dollars and there were no conversion losses. During fiscal year 2023, the Company held the majority of its cash balances in U.S. dollars and there were no conversion losses. See Item 18. “Financial Statements - Note 25 - Financial Instruments” for disclosures about financial risk management including interest rate risk, foreign currency risk and liquidity risk.

Convertible note (Triaxial)

During the fiscal year ended 30 June 2013 the Company issued Convertible Notes with a face value of A$1,500,000 to Triaxial in consideration of the acquisition of patents and intellectual property assets. The terms of these Convertible Notes were amended on 4 December 2014. The amended terms allow the conversion of debt into ordinary shares, provided that the Company achieves certain milestones. Accordingly, the Convertible Note has been reclassified as an equity instrument rather than debt instrument.

During fiscal year 2017, the Company reached two milestones that triggered the conversion of a portion of its Convertible Notes. On 14 September 2016 the directors approved the issuance of 20,000,000 ordinary shares as a consequence of a conversion of A$500,000 of the Convertible Notes, and on 1 November 2016 a further 16,000,000 ordinary shares were issued as a result of the conversion of a further portion of the Convertible Notes. During fiscal year 2018, one of the noteholders waived his rights to the remaining tranche of convertible notes, resulting in the reduction of the convertible note carrying value by a further A$136,000. On 21 April 2022, the completion of the phase II study of paxalisib in glioblastoma (NCT03522298) was announced and on 5 May 2022 the remaining portion of the convertible note with a carrying value of A$464,000 was extinguished and converted to 1,855,357 ordinary shares.

C. Research and development, Patents and Licenses, etc.

Expenditures during the research phase of a project are recognized as an expense when incurred. Development costs are capitalized only when technical feasibility studies identify that the project will deliver future economic benefits and these benefits can be measured reliably.

Research and development expenses consist primarily of costs incurred for the development of our product candidates, which include:

| • |  | expenses incurred under agreements with academic research centers, clinical research organizations and investigative sites that conduct our clinical trials; and

| • |  | the cost of acquiring, developing, and manufacturing clinical trial materials.

We cannot determine with certainty the duration and completion costs of the current or future product development, pre-clinical studies or clinical trials of our product candidates. The duration, costs, and timing of clinical trials and development of our product candidates will depend on a variety of factors, including:

| • |  | the scope, rate of progress, and expense of our ongoing as well as any additional clinical trials and other research and development activities;

| • |  | the countries in which trials are conducted;

| • |  | future clinical trial results;

| • |  | uncertainties in clinical trial enrollment rates or drop-out or discontinuation rates of patients;

| • |  | potential additional safety monitoring or other studies requested by regulatory agencies;

| • |  | significant and changing government regulation; and

| • |  | the timing and receipt of any regulatory approvals.

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A change in the outcome of any of these variables with respect to the development of a product candidate could mean a significant change in the costs and timing associated with the development of that product candidate. For example, if the FDA, or another regulatory authority were to require us to conduct clinical trials beyond those that we anticipate will be required to complete clinical development of a product candidate or if we experience significant delays in enrollment in any of our clinical trials, we could be required to expend significant additional financial resources and time on the completion of clinical development.

In fiscal years 2024, 2023, 2022 and we spent, respectively, a total of A$17.4 million, A$15.6 million, A$20.2 million (restated) and on company-sponsored research and development activities.

D. Trend Information

Further to the risk factors discussed in Item 3D, we note that the financial information disclosed in the SEC Form 20-F may not be indicative of future results in the following areas:

| • |  | While we anticipate that funds will continue to be spent on research and development of our drug candidates, the amounts expended in recent years may not be indicative of the amounts to be expended in future years, because we may have more or fewer drug candidates, they may be at different stages of their lifecycle and the trials deemed suitable for their development may be more or less costly;

| • |  | We did not generate revenue from licensing transactions in fiscal year 2023 and 2022 and we may not generate any revenue in future years. Should the Company generate revenues in future years, the amounts generated in fiscal year 2021 may not be representative of any such revenues in future years. This could be as a result of whether any further licensing transactions are entered into, as well as whether any milestones are met in relation to license agreements already in place; and

| • |  | The quantum of general and administrative expenditures in recent years may not be indicative of the expenditures required in future years.

E. Critical Accounting Estimates - see Note 2. Material accounting policies

Item 6. | Directors, Senior Management and Employees

A. Directors and Senior Management

The names and details of the Company’s Directors and senior management at the date of this report are as follows:

John Friend |  | Chief Executive Officer, Managing Director (Appointed 1 August 2023)
Bryce Carmine |  | Chairman, Non-Executive Director
Steven Coffey |  | Non-Executive Director
Ebru Davidson |  | Non-Executive Director
Robert Apple |  | Non-Executive Director (Appointed 15 January 2024)
Jeffrey Bonacorda |  | Vice President, Finance and Controller (Appointed 24 June 2024)
Elissa Hansen |  | Company Secretary (Appointed 14 June 2024)

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Directors were in office for the entire period unless otherwise stated.

Names, titles, experience and expertise

Name: |  | Bryce Carmine
Title: |  | Chairman, Non-Executive Director
Qualifications: |  | B.Sc., Biochemistry, Microbiology & Genetics
Experience and expertise: |  | Bryce spent 36 years working for Eli Lilly & Co. and retired as Executive Vice President for Eli Lilly & Co, and President, Lilly Bio-Medicines. Prior to this he led the Global Pharmaceutical Sales and Marketing and was a member of the Company’s Executive Committee. Bryce previously held a series of product development portfolio leadership roles culminating when he was named President, Global Pharmaceutical Product Development, with responsibility for the entire late-phase pipeline development across all therapeutic areas for Eli Lilly. During his career with Lilly, Bryce held several country leadership positions including President Eli Lilly Japan, Managing Dir. Australia/NZ & General Manager of a JV for Lilly in Seoul, Korea. Bryce is currently Chairman and CEO of HaemaLogiX Pty Ltd, a Sydney based privately owned biotech.
Other current directorships: |  | None
Former directorships (last 3 years): |  | None
Special responsibilities: |  | Chair of Remuneration and Nomination Committee, member of Audit, Risk and Governance Committee.
Name: |  | Steven Coffey
Title: |  | Non-Executive Director
Qualifications: |  | B. Comm, CA
Experience and expertise: |  | Steven is a Chartered Accountant and registered company auditor and has over 35 years experience in the accounting and finance industry. He has been a partner with the chartered accounting firm Watkins Coffey Martin which recently merged with Charternet Chartered Accountants and Steven is a consultant to that group. Steven sits on the board of a number of large private family companies and audits a number of large private companies and not-for-profit entities.
Other current directorships: |  | None
Former directorships (last 3 years): |  | Ansarada Group Limited (ASX: AND) formerly The Docyard Limited (ASX:TDY)
Special responsibilities: |  | Chair of Audit, Risk and Governance Committee, member of Remuneration and Nomination Committee.
Name: |  | Ebru Davidson
Title: |  | Non-Executive Director - from 5 June 2023
Qualifications: |  | BSc, JD (Hons), AGIA, GAICD
Experience and expertise: |  | Ms Davidson is a highly experienced corporate lawyer and is currently the General Counsel for QBiotics Group Limited, an unlisted public Australian life sciences company. Prior to this, Ms Davidson was a partner at national law firm Thomson Geer Lawyers and has over 14 years’ experience in equity capital markets, private and public mergers and acquisitions, corporate transactions and corporate governance. Ms Davidson also has extensive experience in advising listed and unlisted entities on compliance and regulatory matters working closely with the Australian Securities and Investment Commission and Australian Securities Exchange.
Other current directorships: |  | None
Former directorships (last 3 years): |  | None
Special responsibilities: |  | None
Name: |  | Robert Apple
Title: |  | Non-Executive Director
Qualifications: |  | B.A.
Experience and expertise: |  | Mr Robert Apple has more than 25 years of senior leadership experience in the pharmaceutical industry, including 16 years with Antares Pharma, Inc. as Senior Vice President, Chief Financial Officer and Corporate Secretary, before going on to become President and Chief Executive Officer from 2016 until its acquisition by Halozyme Therapeutics in 2022. Mr. Apple also served on the Board of Directors at Antares from 2016 until May 2022. He previously served on the Board of Directors of InKine Pharmaceutical, PaxMedica Inc., and Kerathin Inc. Prior to joining Antares, Mr. Apple served as Chief Operating and Financial Officer at InKine Pharmaceutical. He also held prior roles at Genaera Corporation, Liberty Technologies, and Arthur Andersen & Company.

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Other current directorships: |  | None
Former directorships (last 3 years): |  | None
Special responsibilities: |  | None
Name: |  | Dr John Friend
Title: |  | Chief Executive Officer (appointed 1 May 2023)
|  | Managing Director (appointed 1 August 2023)
|  | Interim Chairman of the Board (appointed 11 August 2023)
|  | Chief Medical Officer to 30 April 2023
Qualifications: |  | B.A., M.D
Experience and expertise: |  | Dr Friend is a highly experienced physician executive who has previously worked with companies ranging from start-up biotechnology companies to multinational pharmaceutical companies. Over the past 15 years, his focus has been in the oncology and hematology therapeutic space. Dr. Friend is a US-trained physician who practiced medicine in North Carolina before transitioning to drug development. Before joining Kazia Therapeutics, he was Chief Medical Officer and member of the executive management team at Cellectar Biosciences, Inc, a US publicly traded biopharmaceutical company.
Other current directorships: |  | None
Former directorships (last 3 years): |  | None
Special responsibilities: |  | None
Name: |  | Jeffrey Bonacorda
Title: |  | Vice President, Finance and Controller
Qualifications: |  | B.A.
Experience and expertise: |  | Mr Jeffrey Bonacorda is a senior accounting professional with more than thirty years of experience in the pharmaceutical, consumer products and service industries. Prior to joining Kazia, Mr Bonacorda held several senior finance positions supporting global R&D development programs and on market pharmaceuticals.
Name: |  | Elissa Hansen
Title: |  | Company Secretary (Appointed 14 June 2024)
Qualifications: |  | Bc., Grad.Dip. AICD, FGIA,
Experience and expertise: |  | Ms Elissa Hansen has over 20 years’ experience as a company secretary and governance professional for both listed and unlisted companies. She is a Chartered Secretary who brings best practice governance advice, ensuring compliance with the Listing Rules, Corporations Act and other relevant legislation..

B. Compensation

Principles used to determine the nature and amount of remuneration

Remuneration philosophy

Remuneration for Directors and Senior Executives is based on the overall objective of attracting and retaining people of high quality who will make a worthwhile contribution to Kazia in the short, medium and long term, and thereby contribute to long term shareholder value. The Board and its Remuneration and Nomination Committee take a balanced position between the need to pay market rates to attract talent, and the financial resources of Kazia, in determining remuneration.

Non-Executive Directors remuneration

The Constitution of Kazia specifies that the aggregate remuneration of Non-Executive Directors shall be determined from time to time by General Meeting. The last determination for the Consolidated Entity was at the Annual General Meeting held on 16 November 2022 when the shareholders approved the new constitution with an aggregate remuneration of $560,000.

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Non-Executive Directors’ fees are reviewed periodically by the Board and are regularly compared with those of companies of comparable market capitalization and stage of development. The Chairman’s fees are determined independently to the fees of other non-executive Directors based on comparative roles in the external market.

The Non-Executive Directors fee structure is a fixed fee model and includes superannuation for Australian based directors.

Executive Directors and other Key Management Personnel (“KMP”)

The Board and the Remuneration and Nomination Committee, in consultation with the Managing Director, have put in place a remuneration structure which provides incentive for employees to drive the activities of the company forward. These arrangements are reviewed annually at the end of the calendar year.

The Board determines an appropriate level of fixed remuneration for the CEO and Group Executives, as well as the proportion of performance-based remuneration.

The executive remuneration and reward framework has three components:

| • |  | fixed remuneration

| • |  | short-term performance incentives - cash bonus

| • |  | share-based payments - award of options through the Employee Share Option Plan (“ESOP”)

Fixed remuneration is reviewed annually by the Remuneration and Nomination Committee based on individual performance, the overall performance of Kazia and comparable market remunerations. The Remuneration and Nomination Committee approved increases in fixed remuneration during fiscal year 2024.

The short-term incentives program is designed to align the targets of Kazia with the performance hurdles of executives. Short-term incentive payments are granted to executives based on specific annual performance objectives, metrics and performance appraisals. Annual performance reviews are conducted at the end of each calendar year and bonuses are paid shortly after the performance reviews are completed. Annual performance objectives cover matters such as progress in clinical trials, and management of the Company’s financial resources.

The Board or the Remuneration and Nomination Committee may, at its discretion, award bonuses for exceptional performance.

The long-term incentive comprises equity-based payments. The Consolidated Entity aims to attract and retain high calibre executives, and align their interests with those of the shareholders, by granting equity-based payments which are issued at the share price on date of issue and vest in tranches based on tenure. The share-options issued to executives are governed by the ESOP.

Employee share option plan

The Employee Share Option Plan (‘ESOP’) was most recently approved by shareholders on 10 November 2021.

The ESOP provides for the issue of options to eligible individuals, being employees, Officers and Non-executive directors of Kazia.

Each option issued under the ESOP entitles its holder to acquire one fully paid ordinary share and is exercisable at a price based on a formula, which includes the weighted average price of such shares at the close of trading on the Australian Securities Exchange for the five days prior to the date of issue. The number of options offered, the amount payable, the vesting period, the option period, the conditions of exercise or any other factors are at the discretion of the Board of Directors.

Kazia issued 2,850,000 ADS options under the ESOP during the financial year ended 30 June 2024, of which 1,500,000 were issued to KMP.

Any change to the ESOP will require approval by shareholders.

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Use of remuneration consultants

During fiscal year 2024, the Company did not engage remuneration consultants to assist with the determination of remuneration levels.

Details of remuneration

Amounts of remuneration

Details of the remuneration of key management personnel of Kazia are set out in the following tables, reported in Australian dollars, the functional currency of the Company, unless otherwise noted.

The KMP of Kazia consisted of the following directors of Kazia Therapeutics Limited:

| • |  | Bryce Carmine - Non-Executive Director, Chairman from 15 January 2023

| • |  | Steven Coffey - Non-Executive Director

| • |  | Iain Ross - Non-Executive Director and Chair - until 11 August 2023

| • |  | Ebru Davidson - Non-Executive Director - from 5 June 2023

| • |  | Robert Apple - Non-Executive Director - from 15 January 2024

And the following persons:

| • |  | Dr John Friend - Chief Executive Officer

| • |  | Gabrielle Heaton - Vice President, Finance and Administration from 1 February 2024 to 30 June 2024

| • |  | Karen Krumeich - Chief Financial Officer until 31 January 2024

|  | Short-term benefits |  |  | Short-term benefits |  |  | Short-term benefits |  |  | Short-term benefits |  |  | Short-term benefits |  |  | Post- employment benefits |  |  | Share-based payments |  |  |  |
|  | Salary & fees Cash |  |  | Bonus Cash |  |  | Movements in accrued leave Non- monetary |  |  | Movements in long service leave Non- monetary |  |  | Healthcare & Insurance Cash |  |  | Super- annuation |  |  | Options Equity- settled |  |  | Total |
2024 |  | $ |  |  | $ |  |  | $ |  |  | $ |  |  | $ |  |  | $ |  |  | $ |  |  | $ |
Non-Executive Directors: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
B Carmine |  |  | 95,417 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 95,417 |
S Coffey |  |  | 85,000 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 9,350 |  |  |  | — |  |  |  | 94,350 |
E Davidson |  |  | 85,000 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 9,350 |  |  |  | — |  |  |  | 94,350 |
R Apple |  |  | 39,301 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 39,301 |
Other Key Management Personnel: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
J Friend * |  |  | 824,998 |  |  |  | — |  |  |  | 44,384 |  |  |  | — |  |  |  | 35,186 |  |  |  | 32,780 |  |  |  | 342,496 |  |  |  | 1,279,844 |
K Krumeich * |  |  | 378,946 |  |  |  | — |  |  |  | 2,307 |  |  |  | — |  |  |  | 7,850 |  |  |  | 9,937 |  |  |  | — |  |  |  | 399,040 |
G Heaton |  |  | 103,333 |  |  |  | — |  |  |  | 1,348 |  |  |  | — |  |  |  | — |  |  |  | 11,367 |  |  |  | 10,941 |  |  |  | 126,989 |
A Sandham |  |  | 147,593 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 147,593 |
E Hansen |  |  | 2,267 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 2,267 |
I Ross |  |  | 109,633 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 109,633 |
|  |  | 1,871,488 |  |  |  | — |  |  |  | 48,039 |  |  |  | — |  |  |  | 43,036 |  |  |  | 72,784 |  |  |  | 353,437 |  |  |  | 2,388,784 |

* | Salary paid in USD, but disclosed in Australian dollars using conversion rate of 0.6673.

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Service agreements

Under Remuneration and Nomination Committee policy, employment contracts are entered into with each of the executives who is considered to be KMP. Under the terms of the contracts, remuneration is reviewed at least annually. The employment contracts of KMPs include a termination clause whereby a party can terminate the agreement on notice. Notice required is 6 months. Under the terms of each contract, payment in lieu can be made by the Consolidated Entity to substitute the notice period. The Consolidated Entity may terminate the contracts at any time without cause if serious misconduct has occurred. In the event that employment is terminated for cause, no severance pay or other benefits are payable by the Consolidated Entity.

Remuneration and other terms of employment for key management personnel are formalized in service agreements. Details of these agreements are as follows:

Name: Title: Agreement commenced: Term of agreement: Details: |  | Dr John Friend Chief Executive Officer 1 May 2023 Full time employment Base salary for the year ending 30 June 2024 of USD550,000 and healthcare and insurance benefits to be reviewed annually by the Remuneration and Nomination Committee. A bonus of up to 60% of base salary, subject to attainment of key objectives and at the discretion of the board. John’s employment with the consolidated entity is at-will, and if terminated, it must pay any outstanding entitlements due to him.

Key management personnel have no entitlement to termination payments in the event of removal for misconduct.

Share-based compensation

Issue of options

The options issued on 22 April 2024 were to John Friend for 1,500,000 ADS options with an exercise price set at the volume weighted average (VWAP) of ADS during the 5 trading days immediately prior to the issue date with a value of A$645,000. Service conditions are that any unvested options are forfeited on cessation of employment. There are no performance conditions, consistent with the Company’s Employee Share Option Plan rules, as re-approved by shareholders on 6 November 2021.

The terms and conditions of each grant of options over ordinary shares granted as remuneration to Directors or other Key Management Personnel in this financial year or future financial years are set out below.

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Issue of ADS options

Grant date |  | Vesting date and exercisable date |  | Expiry date |  | Exercise price |  |  | Fair value per option at grant date |
22 April 2024 |  | 22 April 2027 |  | 22 April 2029 |  | A$ | 0.586 |  |  | A$ | 0.43 |

Options granted carry no dividend or voting rights. Each option is convertible to one ordinary share upon exercise.

Pension benefits

The Company paid A$72,784 during fiscal year 2024 for employee superannuation benefits and pension benefits related to KMPs.

C. Board Practices

The role of the Board is as follows:

| • |  | representing and serving the interests of shareholders by overseeing and appraising the strategies, policies and performance of the Company. This includes overviewing the financial and human resources the Company has in place to meet its objectives and the review of management performance;

| • |  | protecting and optimizing Company performance and building sustainable value for shareholders in accordance with any duties and obligations imposed on the Board by law and the Company’s Constitution and within a framework of prudent and effective controls that enable risk to be assessed and managed; responsible for the overall Corporate Governance of Kazia Therapeutics Limited and its subsidiaries, including monitoring the strategic direction of the Company and those entities, formulating goals for management and monitoring the achievement of those goals;

| • |  | setting, reviewing and ensuring compliance with the Company’s values (including the establishment and observance of high ethical standards); and

| • |  | ensuring shareholders are kept informed of the Company’s performance and major developments affecting its state of affairs.

Responsibilities/functions of the Board include:

| • |  | selecting, appointing and evaluating from time to time the performance of, determining the remuneration of, and planning for the successor of, the CEO;

| • |  | reviewing procedures in place for appointment of senior management and monitoring of its performance, and for succession planning. This includes ratifying the appointment and the removal of the Company Secretary;

| • |  | overseeing the Company, including its control and accountability systems;

| • |  | input into and final approval of management development of corporate strategy, including setting performance objectives and approving operating budgets;

| • |  | reviewing and guiding systems of risk management and internal control and ethical and legal compliance. This includes reviewing procedures in place to identify the main risks associated with the Company’s businesses and the implementation of appropriate systems to manage these risks;

| • |  | overseeing and monitoring compliance with the Code of Conduct and other corporate governance policies;

| • |  | monitoring corporate performance and implementation of strategy and policy;

| • |  | approving major capital expenditure, acquisitions and divestitures, and monitoring capital management;

| • |  | monitoring and reviewing management processes in place aimed at ensuring the integrity of financial and other reporting;

| • |  | monitoring and reviewing policies and processes in place relating to occupational health and safety, compliance with laws, and the maintenance of high ethical standards; and

| • |  | performing such other functions as are prescribed by law or are assigned to the Board.

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In carrying out its responsibilities and functions, the Board may delegate any of its powers to a Board committee, a director, employee or other person subject to ultimate responsibility of the directors under the Corporations Act.

Matters which are specifically reserved for the Board or its committees include the following:

| • |  | appointment of a Chair;

| • |  | appointment and removal of the CEO;

| • |  | appointment of directors to fill a vacancy or as additional directors;

| • |  | establishment of Board committees, their membership and delegated authorities;

| • |  | approval of dividends;

| • |  | development and review of corporate governance principles and policies;

| • |  | approval of major capital expenditure, acquisitions and divestitures in excess of authority levels delegated to management;

| • |  | calling of meetings of shareholders; and

| • |  | any other specific matters nominated by the Board from time to time.

Structure of the Board

The Company’s Constitution governs the regulation of meetings and proceedings of the Board. The Board determines its size and composition, subject to the terms of the Constitution. The Board does not believe that it should establish a limit on tenure other than stipulated in the Company Constitution (refer to ‘Term of Directors’ below).

While tenure limits can help to ensure that there are fresh ideas and viewpoints available to the Board, they hold the disadvantage of losing the contribution of directors who have been able to develop, over a period of time, increasing insight in the Company and its operation and, therefore, an increasing contribution to the Board as a whole. It is intended that the Board should comprise a majority of independent non-executive directors and comprise directors with a broad range of skills, expertise and experience from a diverse range of backgrounds. The Board regularly reviews the independence of each director in light of the interests disclosed to the Board.

The Board only considers directors to be independent where they are independent of management and free of any business or other relationship that could materially interfere with, or could reasonably be perceived to interfere with, the exercise of their unfettered and independent judgment. The Board has adopted a definition of independence based on that set out in Principle 2.3 of the ASX Corporate Governance Principles and Recommendations (4th edition). The Board will review the independence of each director in light of interests disclosed to the Board from time to time. In accordance with the definition of independence above, and the materiality thresholds set, the Board considers Bryce Carmine, Steven Coffey and Ebru Davidson to be independent directors.

There are procedures in place, agreed by the Board, to enable directors in furtherance of their duties to seek independent professional advice at the Company’s expense. The appointment and expiration dates of each director in office at the date of this report is as follows:

Name |  | Position |  | Year First Appointed |  | Current term expires
Dr John Friend |  | Managing Director, CEO |  | 2023 |  | N/A*
Bryce Carmine |  | Non-executive Director |  | 2015 |  | Nov-26
Steven Coffey |  | Non-executive Director |  | 2012 |  | Nov-25
Ebru Davidson (appointed 5 June 2023) |  | Non-executive Director |  | 2023 |  | Nov-26
Robert Apple (appointed 15 January 2024) |  | Non-executive Director |  | 2024 |  | Nov-24

* | The managing director is exempt from standing for re-election under the Company’s constitution and Australian corporate law.

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Further details on each director can be found in “Names, titles, experience and expertise” above.

Term of Directors

The Company’s Constitution requires that at each Annual General Meeting of the Company, one third (or the number nearest to but not exceeding one third) of the directors, (excluding a director who is the Managing Director, and a director appointed to fill a casual vacancy) must retire from office provided that no director may retain office for more than three years without offering himself/herself for re-election even though such submission results in more than one third of the directors retiring from office.

The Board of Directors has the power to appoint any person to be a director either to fill a casual vacancy or as an additional director (up to a maximum of 10). Any director so appointed may hold office only until the next Annual General Meeting when he or she shall be eligible for election by the Company shareholders.

Board of Directors

The Board of Kazia is elected by and accountable to shareholders. The Board monitors and directs the business and is responsible for the corporate governance of the Company. As of 30 June 2024, the Board comprised of five directors, four of whom were non-executive directors.

We do have a ‘diverse’ board of directors as defined in NASDAQ Rule 5605(f). Kazia is a small company with five Directors. As noted in the Board Diversity Matrix Part II Demographic Background section, it is the opinion of the company that we do meet the requirements of a diverse Board.

Board Diversity as of 26 October 2024

|  | Female |  |  | Male |  |  | Non- Binary |  |  | Did Not Disclose Gender |
Country of Principal Executive Offices: Australia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Foreign Private Issuer: Yes |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disclosure Prohibited Under Home Country Law: No |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total Number of Directors: 4 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Part I: Gender Identity |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Directors |  |  | 1 |  |  |  | 4 |  |  |  |  |  |  |  |  |
Part II Demographic Background |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
African American or Black |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Alaskan Native or Native American |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Asian |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Hispanic or Latinx |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Native Hawaiian or Pacific Islander |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
White |  |  |  |  |  |  | 4 |  |  |  |  |  |  |  |  |
Two or More Races or Ethnicities |  |  | 1 |  |  |  |  |  |  |  |  |  |  |  |  |
LGBTQ+ |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Did Not Disclose Demographic Background |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

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Committees

The Board has established an Audit, Risk and Governance Committee and a Remuneration and Nomination Committee.

Audit, Risk and Governance Committee

The Board has established an Audit, Risk and Governance Committee which operates under a Charter approved by the Board, which is available on the Company’s website. It is the Board’s responsibility to ensure that an effective internal control framework exists within the entity. This includes internal controls to deal with both the effectiveness and efficiency of significant business processes, the safeguarding of assets, the maintenance of proper accounting records, and the reliability of financial information as well as non-financial considerations such as the benchmarking of operational key performance indicators. The Board has delegated responsibility for establishing and maintaining a framework of internal control and ethical standards to the Audit, Risk and Governance Committee.

The Committee also provides the Board with additional assurance regarding the reliability of financial information for inclusion in the financial reports.

Members of the Audit, Risk and Governance Committee are Steven Coffey (Chairman) and Bryce Carmine, each of whom is an independent director.

Remuneration and Nomination Committee

The purpose of the Remuneration and Nomination Committee is to assist and advise the Board to develop, implement and, from time to time, update policies in relation to:

| • |  | the selection, nomination and appointment processes for directors; and

| • |  | the remuneration of key management personnel and directors.

This committee is accountable to the Board for its performance and is subject to an annual review by the Board. Members of the Remuneration and Nomination Committee are Bryce Carmine (Chairman) and Steven Coffey each of whom is an independent director.

Performance

The performance of the Board and key executives is reviewed regularly using both measurable and qualitative indicators.

On at least a bi-annual basis, directors will provide written feedback in relation to the performance of the Board and its Committees against a set of agreed criteria:

| • |  | each Committee of the Board will also be required to provide feedback in terms of a review of its own performance;

| • |  | feedback will be collected by the chair of the Board, or an external facilitator, and discussed by the Board, with consideration being given as to whether any steps should be taken to improve performance of the Board or its Committees;

| • |  | the Chief Executive Officer will also provide feedback from senior management in connection with any issues that may be relevant in the context of Board performance review; and

| • |  | where appropriate to facilitate the review process, assistance may be obtained from third party advisors.

Remuneration

It is the Company’s objective to provide maximum shareholder benefit from the retention of a high-quality Board and executive team by remunerating directors and key executives fairly and appropriately with reference to relevant employment market conditions. To assist in achieving this objective, the Board, in assuming the responsibilities of assessing remuneration to employees, links the nature and amount of executive directors’ and officers’ remuneration to the Company and Company’s financial and operational performance.

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The expected outcomes of the remuneration structure are:

| • |  | retention and motivation of key executives;

| • |  | attraction of high-quality management to the Company; and

| • |  | performance incentives that allow executives to share in the success of Kazia Therapeutics Limited.

For a more comprehensive explanation of the Company’s remuneration framework and the remuneration received by directors and key executives in the current period, please refer to the section “Compensation” above.

There is no plan to provide retirement benefits to executive or non-executive directors, except for the Australian Government Superannuation Guarantee.

The Remuneration and Nomination Committee is responsible for determining and reviewing compensation arrangements for the directors themselves and the Chief Executive Officer and executive team.

D. Employees

As of the end of each of the last three fiscal years, the Company employed the following number of people-FTEs:

Category of Activity |  | 2024 |  |  | 2023 |  |  | 2022 |
Research and Development |  |  | 5.0 |  |  |  | 6.8 |  |  |  | 6.8 |
Finance and Administration |  |  | 1.8 |  |  |  | 2.0 |  |  |  | 2.2 |
Total |  |  | 6.8 |  |  |  | 8.8 |  |  |  | 9.0 |
Geographic Location |  | 2024 |  |  | 2023 |  |  | 2022 |
Australia |  |  | 3.0 |  |  |  | 5.0 |  |  |  | 5.3 |
United States |  |  | 3.8 |  |  |  | 4.0 |  |  |  | 1.0 |
Total |  |  | 6.8 |  |  |  | 9.0 |  |  |  | 6.3 |

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E. Share Ownership

Directors’ and KMP interests in the shares and options of the Company for fiscal year 2024:

Shareholding

The number of shares in the company held during the financial year by each director and other members of Key Management Personnel of the Consolidated Entity, including their personally related parties, is set out below:

|  | Balance at the start of the year |  |  | Purchased on market |  |  | Share Purchase Plan |  |  | Off market additions/ disposals |  |  | Disposed* (For KMP reporting purposes only) |  |  | Balance at the end of the year |
Ordinary shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
B Carmine |  |  | 856,681 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 856,681 |
S Coffey |  |  | 991,993 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 991,993 |
I Ross |  |  | 1,522,729 |  |  |  | — |  |  |  | — |  |  |  | (1,522,729 | ) |  |  | — |  |  |  | — |
J Garner |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
J Friend |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
K Krumeich |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
E Davidson |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
|  |  | 3,371,403 |  |  |  | — |  |  |  | — |  |  |  | (1,522,729 | ) |  |  | — |  |  |  | 1,848,674 |

Each Director and Key Management Personnel owns less than 1% of shareholding.

Other transactions with key management personnel and their related parties

John Friend was for reimbursed travel and accommodation expenses of $105,542.

Ebru Davidson was reimbursed travel and accommodation expenses of $2,386.

Ian Ross was reimbursed travel and accommodation expenses of $7,402.

Option holding

The number of options over ordinary shares in the company held during the financial year by each Director and other members of Key Management Personnel of Kazia, including their personally related parties, is set out below:

|  | Balance at the start of the year |  |  | Granted as renumeration |  |  | Forfeited |  |  | Disposed* (For KMP reporting purposes only) |  |  | Balance at the end of the year |
Options over ordinary shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
I Ross |  |  | 400,000 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 400,000 |
B Carmine |  |  | 400,000 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 400,000 |
S Coffey |  |  | 400,000 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 400,000 |
J Friend |  |  | 4,800,000 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 4,800,000 |
K Krumeich |  |  | 2,800,000 |  |  |  | — |  |  |  | (2,800,000 | ) |  |  | — |  |  |  | — |
|  |  | 8,800,000 |  |  |  | — |  |  |  | (2,800,000 | ) |  |  | — |  |  |  | 6,000,000 |

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|  | Balance at the start of the year |  |  | Granted as remuneration |  |  | Forfeited |  |  | Disposed (for KMP reporting purposes only) |  |  | Balance at the end of the year |
Options over ADS |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
J Friend |  |  | — |  |  |  | 1,500,000 |  |  |  | — |  |  |  | — |  |  |  | 1,500,000 |
|  |  | — |  |  |  | 1,500,000 |  |  |  | — |  |  |  | — |  |  |  | 1,500,000 |

Share-based compensation

There were no shares issued to Directors or other KMP as part of compensation during fiscal year 2024.

Item 7. | Major Shareholders and Related Party Transactions

A. Major shareholders

As at the date of this Annual Report, no shareholders hold a beneficial ownership of 5% or more of our voting securities.

Significant Changes in the Ownership of Major Shareholders

There have been no significant changes in the ownership of major shareholders.

Major Shareholders Voting Rights

All of our shareholders, including the shareholders listed below, have the same voting rights attached to their ordinary shares.

Record Holders

As of October 28, 2024, there were 2,193 Kazia shareholders holding 435,496,534 fully paid ordinary shares. These numbers are not representative of the number of beneficial holders of our shares nor are they representative of where such beneficial holders reside, since many of these ordinary shares were held of record by brokers or other nominees. The majority of trading by our U.S. investors is done by means of ADS that are held of record by HSBC Custody Nominees (Australia) Ltd., which held 418,260,593 (96.04%) of our ordinary shares as of such date.

B. Related party transactions

During fiscal year 2024, and up to the date of this report, we did not enter into any transactions or loans with any: (i) enterprises that directly or indirectly, through one or more intermediaries, control, are controlled by or are under common control with us; (ii) associates; (iii) individuals owning, directly or indirectly, an interest in our voting power that gives them significant influence over us, and close members of any such individual’s family; (iv) executive officers and close members of such individuals’ families; or (v) enterprises in which a substantial interest in our voting power is owned, directly or indirectly, by any person described in (iii) or (iv) or over which such person is able to exercise significant influence.

Transactions between related parties, when they occur, are on normal commercial terms and the conditions no more favorable than those available to other non-related parties.

C. Interests of Experts and Counsel

Not applicable.

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Item 8. | Financial Information

A. Consolidated Statements and Other Financial Information

Consolidated financial statements are included in Item 18. “Financial Statements” commencing on page F-1.

Legal proceedings

Dividends

There were no dividends paid, recommended or declared during fiscal years 2024, 2023 or 2022.

B. Significant Changes

On October 15, 2024, Kazia announced that it planned to effect an ADS ratio change to change the ratio of ADSs to ordinary shares from one ADS to ten ordinary shares to the new ratio of one ADS to one hundred ordinary shares. The ADS ratio change will have the same effect as a one-for-ten reverse ADS split for Kazia’s ADS holders. There will be no change to Kazia’s underlying ordinary shares, and no ordinary shares will be issued or cancelled in connection with the ADS ratio change.The ADS ratio change became effective on October 28, 2024.

Item 9. | The Offer and Listing

A. Offer and listing details

See Item 9C for more information.

B. Plan of Distribution

Not applicable.

C. Markets

Kazia’s ordinary shares trade in the U.S. in the form of ADSs on the Nasdaq Capital Market. Each ADS represents 100 ordinary shares of Kazia. The trading symbol on the Nasdaq Capital Market is ‘KZIA’. Kazia has entered into a Deposit Agreement with The Bank of New York Mellon under which the Bank of New York, acting as depository, issues the ADSs.

D. Selling Shareholders

Not applicable.

E. Dilution

Not applicable.

F. Expenses of the issue

Not applicable.

Item 10. | Additional Information

A. Share Capital

Not applicable.

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B. Our Constitution

Our Constitution is similar in nature to the bylaws of a U.S. corporation. It does not provide for or prescribe any specific objectives or purposes of Kazia. Our Constitution is subject to the terms of the Corporations Act. It may be amended or repealed and replaced by special resolution of shareholders, passed by at least 75% of the votes cast by shareholders entitled to vote on the resolution.

Under Australian law, a company has the legal capacity and powers of an individual both within and outside Australia. The material provisions of our Constitution are summarized below. This summary is not intended to be complete nor to constitute a definitive statement of the rights and liabilities of our shareholders, and is qualified in its entirety by reference to the complete text of our Constitution, a copy of which is incorporated by reference as Exhibit 1.1 to this Annual Report.

Interested Directors

Subject to the Corporations Act, neither a director nor that director’s alternate may vote in respect of any contract or arrangement in which the director has, directly or indirectly, any material interest according to our Constitution. However, that director may execute or otherwise act in respect of that contract or arrangement notwithstanding any material personal interest. Unless a relevant exception applies, the Corporations Act requires our directors to provide disclosure of any material personal interest, and prohibits directors from voting on matters in which they have a material personal interest or being present while such matter is being considered at the board meeting. In addition, the Corporations Act requires shareholder approval of any provision of related party benefits to our directors.

Directors compensation

Our directors are paid remuneration for their services as directors (but excluding any remuneration payable to a director under any executive services contract with us or one of our related bodies corporate) which is determined in a general meeting of shareholders. The aggregate, fixed sum for directors’ remuneration is to be divided among the directors in such proportion as the directors themselves agree and in accordance with our Constitution. The fixed sum remuneration for directors may not be increased except at a general meeting of shareholders and the particulars of the proposed increase are required to have been provided to shareholders in the notice convening the meeting. In addition, executive directors may be paid remuneration as determined by the directors from time to time and including as a salary, commission or participation in profits and/or subject to the Corporations Act by the issue of shares, options to acquire shares or performance rights or other incentives (or a combination of any of these methods of remuneration).

Fees payable to our non-executive directors must be by way of a fixed sum and not by way of a commission on or a percentage of profits. Remuneration paid to our executive directors must also not include a commission or percentage of operating revenue.

Pursuant to our Constitution, if, at our board’s request, any director performs extra services or makes special exertions, Kazia may remunerate that director by paying for those services and exertions.

In addition to other remuneration provided in our Constitution, all of our directors are entitled to be paid by us for all other travelling, accommodation and other expenses incurred by the directors in attending and returning from general meetings, board meetings, committee meetings or otherwise in connection with our business.

Borrowing powers exercisable by Directors

Our board of directors has the power to raise or borrow money or obtain other financial accommodation for Company purposes, and may grant security for the repayment of that sum or sums or the payment, performance or fulfilment of any debts, liabilities, contracts or obligations incurred or undertaken by the Company in any manner and on any terms and conditions as our board thinks fit.

Retirement of Directors

Pursuant to our Constitution, at least one director, other than the Managing Director, must retire from office at every annual general meeting unless there has been an election of directors earlier that year. A director, other than the director who is the Managing Director, must retire from office at the conclusion of three years or following the third annual general meeting after which the director was elected, whichever is longer. If no director is required to retire at an annual general meeting, then the director to retire will be the director who has been longest in office since last being elected. Retired directors are eligible for a re-election to the board of directors unless disqualified from acting as a director under the Corporations Act or our Constitution.

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Rights and restrictions on classes of shares

The rights attaching to our ordinary shares are detailed in our Constitution. Our Constitution provides that our directors may issue shares with any preferential, deferred or special rights, privileges or conditions or with any restriction (whether in relation to dividends, voting, return of share capital or otherwise) as our board of directors may determine. Subject to any approval which is required from our shareholders under the Corporations Act, we may issue further shares on such terms and conditions as our board of directors resolves.

Dividend rights

Subject to our Constitution and the Corporations Act, our board of directors may from time to time determine to pay and declare dividends to shareholders. Except as otherwise provided by law, all dividends unclaimed for one year after having been declared may be invested or otherwise made use of by our board of directors for our benefit until claimed or otherwise disposed of in accordance with our Constitution.

Voting rights

Under our Constitution, the rights and restrictions attaching to a class of shares, each shareholder has one vote on a show of hands at a meeting of the shareholders unless a poll is demanded under the Constitution or the Corporations Act. On a poll vote, each shareholder shall have one vote for each fully paid share and a fractional vote for each share held by that shareholder that is not fully paid, such fraction being equivalent to the proportion of the amount that has been paid to such date on that share. Shareholders may vote in person or by proxy, attorney or representative. Under Australian law, shareholders of a public company are generally not permitted to approve corporate matters by written consent. Our Constitution does not provide for cumulative voting. Note that ADS holders may not directly vote at a meeting of the shareholders but may instruct the depository to vote the number of deposited ordinary shares their ADSs represent in accordance with the underlying deposit agreement.

Right to share in our profits

Pursuant to our Constitution, our shareholders are entitled to participate in our profits by payment of dividends. Our board of directors may from time to time determine to pay dividends to the shareholders; however, no dividend is payable except in accordance with the Corporations Act and our Constitution.

Rights to share in the surplus in the event of winding up

Our Constitution provides for the right of shareholders to participate in a surplus in the event of our winding up, subject to the rights attaching to a class of shares, the Constitution, and the Corporations Act.

No redemption provision for ordinary shares

There are no redemption provisions in our Constitution in relation to ordinary shares. Under our Constitution, any preference shares may be issued on the terms that they are, or may at the option of Kazia or the holder be, liable to be redeemed or converted into ordinary shares.

Variation or cancellation of share rights

Subject to the Corporations Act and the terms of issue of shares of that class, the rights attached to shares in a class of shares may only be varied or cancelled by either:

| • |  | a special resolution passed at a meeting of members holding shares in that class; or

| • |  | the written consent of members with at least 75% of the shares in that class.

Directors may make calls

Our Constitution provides that our directors may make calls on a shareholder for all monies unpaid on shares held by that shareholder, other than monies payable at fixed times under the conditions of allotment.

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General Meetings of Shareholders

General meetings of shareholders may be called by our board of directors. Except as permitted under the Corporations Act, shareholders may not convene a meeting. The Corporations Act requires the directors to call and arrange to hold a general meeting on the request of shareholders with at least 5% of the votes that may be cast at a general meeting. Notice of the proposed meeting of our shareholders is required at least 21 days prior to such meeting under the Corporations Act.

Foreign Ownership Regulation

Our Constitution does not impose specific limitations on the rights of non-residents to own securities. However, acquisitions and proposed acquisitions of securities in Australian companies may be subject to review and approval by the Australian Federal Treasurer under the Foreign Acquisitions and Takeovers Act 1975 (Cth) (the “Foreign Takeovers Act”), which generally applies to acquisitions or proposed acquisitions:

| • |  | by a foreign person (as defined in the Foreign Takeovers Act) or associated foreign persons that would result in such persons having an interest in 20% or more of the issued shares of, or control of 20% or more of the voting power in, an Australian company; and

| • |  | by non-associated foreign persons that would result in such foreign persons having an aggregate interest in 40% or more of the issued shares of, or control of 40% or more of the voting power in, an Australian company, where the Australian company is valued above the monetary threshold prescribed by Foreign Takeovers Act.

However, in general terms, any such review or approval under the Foreign Takeovers Act will only be required if the foreign acquirer is a U.S. entity or an entity from certain other countries and the value of the total assets of the Australian company or the value of the total issued securities of the Australian company is more than A$1,427 billion, unless that company operates in certain sensitive industries. Exemptions do not generally apply to investments (regardless of the monetary value) by foreign persons if the Australian company is a national security business or investments in any such company by foreign governments and their associated entities.

The Australian Federal Treasurer may prevent a proposed acquisition in the above categories or impose conditions on such acquisition if the Treasurer is satisfied that the acquisition would be contrary to Australia’s national interest or national security. If a foreign person acquires shares, assets or an interest in shares or assets in an Australian company in contravention of the Foreign Takeovers Act, the Australian Federal Treasurer may make a range of orders including an order the divestiture of such person’s shares or interest in shares in that Australian company. Further, breaches of the Foreign Takeovers Act may result in significant fines or court ordered civil and criminal penalties, including imprisonment and substantial monetary penalties.

Ownership Threshold

There are no specific provisions in our Constitution that require a shareholder to disclose ownership above a certain threshold. As we are also a U.S. public company, our shareholders are subject to disclosure requirements under U.S. securities laws.

Issues of Shares and Change in Capital

Subject to our Constitution, the Corporations Act and any other applicable law, we may at any time issue shares and give any person a call or option over any shares on any terms, with preferential, deferred or special rights, privileges or conditions or with any restrictions and for the consideration and other terms that the directors determine.

Subject to the requirements of our Constitution, the Corporations Act and any other applicable law, including relevant shareholder approvals, we may consolidate or divide our share capital into a larger or smaller number by resolution, reduce our share capital in any manner (provided that the reduction is fair and reasonable to our shareholders as a whole, does not materially prejudice our ability to pay creditors and obtains the necessary shareholder approval) or buy back our ordinary shares whether under an equal access buy-back or on a selective basis.

Change of Control

Takeovers of Australian public companies, such as Kazia, are regulated by the Corporations Act, which prohibits the acquisition of a “relevant interest” in issued voting shares in a listed company if the acquisition will lead to that person’s or someone else’s “voting power” (being the person’s relevant interests plus those of its associates) in Kazia’s issued shares increasing from 20% or below to more than 20% or increasing from a starting point that is above 20% and below 90% (“Takeovers Prohibition”), subject to a range of exceptions.

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Generally, a person will have a relevant interest in securities if the person:

| • |  | is the holder of the securities or the holder of an ADS over the shares;

| • |  | has power to exercise, or control the exercise of, a right to vote attached to the securities; or

| • |  | has the power to dispose of, or control the exercise of a power to dispose of, the securities, including any indirect or direct power or control.

If, at a particular time:

| • |  | a person has a relevant interest in issued securities; and

| • |  | the person has:

| • |  | entered or enters into an agreement with another person with respect to the securities;

| • |  | given or gives another person an enforceable right, or has been or is given an enforceable right by another person, in relation to the securities (whether the right is enforceable presently or in the future and whether or not on the fulfillment of a condition); or

| • |  | granted or grants an option to, or has been or is granted an option by, another person with respect to the securities; and

| • |  | the other person would have a relevant interest in the securities if the agreement were performed, the right enforced or the option exercised.

then the other person is taken to already have a relevant interest in the securities.

There are a number of exceptions to the Takeovers Prohibition on acquiring a relevant interest in issued voting shares above 20%. In general terms, some of the more significant exceptions include:

| • |  | when the acquisition results from the acceptance of an offer under a formal takeover bid;

| • |  | when the acquisition has been previously approved by shareholders of Kazia by resolution passed at general meeting;

| • |  | an acquisition by a person if, throughout the six months before the acquisition, that person or any other person has had voting power in Kazia of at least 19% and, as a result of the acquisition, none of the relevant persons would have voting power in Kazia more than three percentage points higher than they had six months before the acquisition;

| • |  | when the acquisition results from the issue of securities under a pro rata rights issue;

| • |  | when the acquisition results from the issue of securities under a dividend reinvestment scheme or bonus share plan;

| • |  | when the acquisition results from the issue of securities under certain underwriting arrangements;

| • |  | when the acquisition results from the issue of securities through a will or through operation of law;

| • |  | an acquisition that arises through the acquisition of a relevant interest in another listed company which is listed on a prescribed financial market or a foreign market approved by the Australian Securities and Investments Commission (“ASIC”); or

| • |  | an acquisition arising through a compromise, arrangement, liquidation or buy-back.

Breaches of the takeovers provisions of the Corporations Act are criminal offenses. ASIC and the Australian Takeover Panel have a wide range of powers relating to breaches of takeover provisions or other circumstances deemed to be unacceptable (whether or not they involve a breach of the takeover provisions), including the ability to make orders canceling contracts, freezing transfers of, and rights attached to, securities, and forcing a party to dispose of securities. There are certain defenses to breaches of the takeover provisions provided in the Corporations Act.

Access to and Inspection of Documents

Inspection of our records is governed by the Corporations Act. Any member of the public has the right to inspect or obtain copies of our registers on the payment of a prescribed fee. Shareholders are not required to pay a fee for inspection of our registers or minute books of the meetings of shareholders. Other corporate records, including minutes of directors’ meetings, financial records and other documents, are not open for inspection by shareholders or any member of the public. However, where a shareholder is acting in good faith and an inspection is deemed to be made for a proper purpose, a shareholder may apply to the court to make an order for inspection of our books.

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C. Material contracts

License Agreement with Genentech Inc.

In October 2016, the Company entered into a worldwide licensing agreement with Genentech, a member of the Roche Group, to develop and commercialize GDC-0084, a small molecule inhibitor of the phosphoinositide-3-kinase (PI3K) pathway. Under the terms of the agreement, the Company paid Genentech an upfront payment of US$5 million. In addition, the terms of the agreement call for performance-related consideration linked to regulatory and commercial outcomes and royalty payments in-line with industry benchmarks.

Acquisition of Glioblast Pty Ltd–Share Sale Agreement with Kilinwata Investments Pty. Ltd., Mi Ok Chong and Paul Hopper

In October 2016, the Company acquired 100% of the issued shares of Glioblast Pty Ltd, a privately-held, neuro-oncology-focused Australian biotechnology company. The transaction included an upfront payment of A$2.1 million, comprising A$600,000 in cash and ordinary fully-paid shares valued at A$1.5 million, with the actual number of shares determined on the basis of the volume-weighted average price of the Company’s shares on the ASX in the seven days prior to this announcement. The shareholders of Glioblast will be eligible for further payments in cash or equity on the achievement of performance related milestones. The first two of these milestones provide for the issue of ordinary fully-paid shares valued at A$1.25 million respectively on commencement and successful completion of a phase II clinical trial of GDC-0084, with the actual number of shares determined on the basis of the volume-weighted average price of the Company’s shares on the ASX in the seven days prior to satisfaction of the relevant milestone being announced. A further two milestones may trigger payments in cash or equity at the Company’s sole discretion. Any issue of equity in the Company will be subject to a minimum six-month escrow period.

At the date of this report, one milestone has lapsed and two have been settled in shares. The remaining milestone relates to the successful completion of a phase II trial in GDC-0084.

Convertible Note Deed Poll and Amendment

On 4 December 2014, we and Triaxial signed a Convertible Note Deed Poll (‘Deed’) which superseded a Loan Agreement. The Deed extinguishes the liability created by the Loan Agreement, which previously allowed for a cash settlement and now allows Triaxial to convert their debt into ordinary shares, provided that the Company achieves defined milestones established in the schedule of the Deed. Accordingly, the convertible note has been reclassified as an equity instrument rather than debt instrument.

During the fiscal 2017, the Company reached two milestones triggering the conversion of a portion of its convertible note as follows;

| • |  | On 11 August 2016, the Company announced the submission of an IND application. On 10 September 2016, the Company received a letter from the FDA advising the study may proceed. This triggered the conversion of Convertible Notes with a face value of A$500,000 into 20,000,000 ordinary shares.

| • |  | On 31 October 2016, the Company announced it had licensed a phase II ready molecule. This triggered the conversion of Convertible Notes with a face value of A$400,000 into 16,000,000 ordinary shares.

During fiscal 2018, A$136,000 of the Convertible Notes was extinguished. The remaining Convertible Notes with a face value of A$464,000 at year end may be converted into 1,856,000 ordinary shares of the Company (post share consolidation).

On 21 April 2022 the completion of the phase II study of paxalisib in glioblastoma (NCT03522298) was announced and on 5 May 2022 the remaining portion of the convertible note was extinguished and converted to 1,855,357 ordinary shares.

Clinical Trial Collaboration and Supply Agreement with the Global Coalition for Adaptive Research

In October 2020, the Company entered into a Clinical Trial Collaboration and Supply Agreement with the Global Coalition for Adaptive Research (GCAR), a US-based 501(C)(3) non-profit organisation. The agreement relates to the inclusion of Kazia’s investigational new drug, paxalisib (GDC-0084) in a phase II/III adaptive clinical trial known as GBM AGILE (NCT03970447), which is expected to serve as the pivotal study for registration of paxalisib in glioblastoma by the US Food and Drug Administration (FDA). Under the terms of the agreement, the Company paid GCAR an upfront payment of US$5 million on execution, and will make

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further payments to GCAR throughout the course of the study, as defined milestones are met, with the total cost of the study capped at a pre-defined amount under the terms of the agreement. GCAR will serve as the sponsor of GBM AGILE and the company will supply investigational product for conduct of the study at its sole expense. It is expected that paxalisib’s participation in GBM AGILE will be approximately three to four years in duration.

Kazia announced on 1 August 2022 that the company had been advised by GCAR that the first stage of the paxalisib arm had completed recruitment. The treatment arm did not meet pre-defined criteria for continuing to a second stage, and patients enrolled in the first stage of the paxalisib arm will therefore continue on treatment as per protocol, and in follow-up, until completion of the final analysis, which we anticipate receiving in 2H CY2023. Depending on the results of the study, Kazia may use such data to support submission of a new drug application for marketing authorization to the FDA.

License Agreement with Vivesto AB (formerly Oasmia Pharmaceutical AB)

In March 2021, the Company entered into an exclusive worldwide license agreement with Vivesto AB, (formerly Oasmia Pharmaceutical AB), an innovation-focused specialty pharmaceutical company, for Cantrixil (TRX-E-002-1), a clinical-stage, first-in-class drug candidate under development for the treatment of ovarian cancer. Under the terms of the agreement, Vivesto assumed worldwide exclusive rights to develop and commercialize Cantrixil for all indications, with an initial focus on ovarian cancer. During fiscal 2021, Vivesto made an up-front payment of US$4 million, with contingent milestones of up to US$42 million and double-digit royalties on commercial sales.

License Agreement with Simcere Pharmaceutical Group Ltd

In March 2021, the Company entered into a licensing agreement with Simcere Pharmaceutical Group Ltd (“Simcere”) to develop and commercialize the Company’s investigational new drug, paxalisib, in Greater China. Under the terms of the agreement, Simcere assumed responsibility for the development, registration and commercialization of paxalisib in Greater China (a territory which includes Mainland China, Hong Kong, Macau and Taiwan). The Company received an upfront payment of US$11 million comprising US$7 million in cash and a US$4 million equity investment, priced at a 20% premium to recent trading. The Company will also receive contingent milestone payments of up to US$281 million for glioblastoma, with further milestones payable for indications beyond glioblastoma. Simcere will additionally pay mid-teen percentage royalties on commercial sales.

License Agreement with Evotec SE

In April 2021, the Company entered into a worldwide exclusive licensing agreement with Evotec SE, a leading European drug discovery and development company, for EVT801, a small-molecule, first-in-class oncology drug candidate. Under the terms of the agreement, Evotec has granted Kazia an exclusive license to develop, manufacture, and commercialize EVT801 in all territories and indications. The Company paid an up-front amount of €1 million (approximately A$1.6 million). In addition, the terms of the agreement call for performance-related consideration linked to regulatory and commercial outcomes up to a maximum of €308 million (approximately A$480 million) and tiered single-digit royalty payments.

License Agreement with Sovargen Co. Ltd

On 21 March 2024, the Company announced that it has entered into an exclusive licensing agreement with Sovargen Co., Ltd, a biotechnology company specializing in central nervous system (CNS) diseases, to develop, manufacture and commercialize paxalisib as a potential treatment of intractable epilepsy in focal cortical dysplasia type 2 (FCD T2) and tuberous sclerosis complex (TSC) disease. Under the agreement, Kazia received an upfront payment of US$1.5 million, potential milestone payments of up to US$19 million upon the achievement of development and regulatory milestones, and a percentage of sub-licensing revenues and royalties on net sales of products incorporating paxalisib. The licensing agreement includes all countries worldwide, excluding mainland China, Hong Kong, Macao and Taiwan.

D. Exchange controls

Australia has largely abolished exchange controls on investment transactions. The Australian dollar is freely convertible into U.S. dollars. In addition, (other than as specified under “taxation” below and certain restrictions imposed under Australian law in relation to dealings with the assets of and transactions with, designated countries, entities and persons specified by the Australian Government Department of Foreign Affairs and Trade from time to time, including, persons connected with terrorism) there are currently no specific rules or limitations regarding the export from Australia of profits, dividends, capital, or similar funds belonging to foreign investors, except that certain payments to non-residents must be reported to the Australian Transaction Reports and Analysis Centre, which monitors such transactions.

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The circumstances in which review and approval by the Australian Federal Treasurer may be required under the Foreign Takeovers Act are summarized above under section B entitled “Foreign Ownership Regulation” in this Annual Report on Form 20-F.

E. Taxation

U.S. Taxation

This section describes certain material U.S. federal income tax consequences to a U.S. holder (as defined below) of owning ordinary shares or ADSs. It applies only to ordinary shares or ADSs that are held as capital assets for tax purposes. This section does not apply to a holder of ordinary shares or ADSs that is a member of a class of holders subject to special rules, including a financial institution, a dealer or trader in securities, a regulated investment company, a real estate investment trust, a grantor trust, a U.S. expatriate, a tax-exempt organization, an insurance company, a person liable for alternative minimum tax, a person who actually or constructively owns 10% or more of the stock of the Company, a person that holds ordinary shares or ADSs as part of a straddle or a hedging or conversion transaction, a person that purchases or sells ordinary shares or ADSs as part of a wash sale for tax purposes, or a person whose functional currency is not the U.S. dollar. Further, this description does not address state, local, non-U.S, or other tax laws, nor does it address the 3.8% U.S. federal Medicare tax on net investment income, the alternative minimum tax or the U.S. federal gift and estate tax consequences of owning and disposing of ordinary shares or ADSs.

For purposes of this description, a “U.S. holder” is a beneficial owner of ordinary shares or ADSs who holds such ordinary shares or ADSs as capital assets within the meaning of the Internal Revenue Code of 1986, as amended, and is, for U.S. federal income tax purposes: (i) an individual citizen or resident of the United States; (ii) a corporation created or organized in or under the laws of the United States or any state thereof, including the District of Columbia; (iii) an estate the income of which is subject to U.S. federal income taxation regardless of its source; or (iv) a trust that either (a) is subject to the supervision of a court within the United States and has one or more U.S. persons with authority to control all substantial decisions or (b) has a valid election in effect under applicable Treasury Regulations to be treated as a U.S. person.

If a partnership holds the ordinary shares or ADSs, the U.S. federal income tax treatment of a partner generally will depend on the status of the partner and the tax treatment of the partnership. A partner in a partnership holding the ordinary shares or ADSs should consult its tax advisor with regard to the U.S. federal income tax treatment of an investment in the ordinary shares or ADSs.

The discussion is based on the Internal Revenue Code of 1986, as amended, administrative pronouncements, judicial decisions, and final, temporary and proposed Treasury Regulations, all as of the date hereof, changes to any of which may affect the tax consequences described herein - possibly with retroactive effect. There can be no assurances that the Internal Revenue Service (the “IRS”) will not take a contrary or different position concerning the tax consequences of the ownership and disposition of our ordinary shares or ADSs or that such a position would not be sustained by a court. We have not obtained, nor do we intend to obtain, a ruling with respect to the U.S. federal income tax considerations relating to the purchase, ownership or disposition of our ordinary shares or ADSs. Holders should consult their tax advisers concerning the U.S. federal, state, local and non-U.S. tax consequences of owning and disposing of our ordinary shares or ADSs in their particular circumstances.

This section is in part based on the representations of the Depositary and the assumption that each obligation in the deposit agreement and any related agreement will be performed in accordance with its terms. In general, for U.S. federal income tax purposes, a holder of ADSs will be treated as the owner of the ordinary shares represented by those ADSs. Exchanges of ordinary shares for ADSs, and ADSs for ordinary shares generally will not be subject to U.S. federal income tax.

Distributions

Subject to the Passive Foreign Investment Company (“PFIC”) rules discussed below, U.S. holders generally will include as dividend income the U.S. dollar value of the gross amount of any distributions of cash or property (without deduction for any withholding tax), other than certain pro rata distributions of ordinary shares, with respect to ordinary shares or ADSs to the extent the distributions are made from our current or accumulated earnings and profits, as determined for U.S. federal income tax purposes. A U.S. holder will include the dividend income on the day actually or constructively received (i) by the holder, in the case of ordinary shares, or (ii) by the depositary, in the case of ADSs. We do not intend to maintain calculations of earnings and profits, as determined for U.S. federal income tax purposes. Consequently, any distributions generally will be treated as dividend income.

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Dividends paid to a non-corporate U.S. holder on shares or ADSs will generally be taxable at the preferential rates applicable to long-term capital gains provided that (a) certain holding period requirements are satisfied, (b) (i) the U.S.-Australia income tax treaty (“the Treaty”) is a qualified treaty and we are eligible for benefits under the Treaty or (ii) our ordinary shares or ADSs are readily tradable on a U.S. securities market, and (c) we were not, in the taxable year prior to the year in which the dividend was paid, and are not, in the taxable year in which the dividend is paid, a PFIC. The Treaty has been approved for the purposes of the qualified dividend rules and the ADSs are listed on Nasdaq. If the Company is a PFIC, any dividends paid to a noncorporate U.S. holder will not qualify for the preferential tax rates ordinarily applicable to “qualified dividends.” In the case of a corporate U.S. holder, dividends on shares and ADSs are taxed as ordinary income and will not be eligible for the dividends received deduction generally allowed to U.S. corporations in respect of dividends received from other U.S. corporations.

The amount of any cash distribution paid in any foreign currency will be equal to the U.S. dollar value of such currency, calculated by reference to the spot rate in effect on the date such distribution is received by the U.S. holder or, in the case of ADSs, by the Depository, regardless of whether and when the foreign currency is in fact converted into U.S. dollars. If the foreign currency is converted into U.S. dollars on the date received, the U.S. holder generally should not recognize foreign currency gain or loss on such conversion. If the foreign currency is not converted into U.S. dollars on the date received, the U.S. holder will have a basis in the foreign currency equal to its U.S. dollar value on the date received, and generally will recognize foreign currency gain or loss on a subsequent conversion or other disposal of such currency. Such foreign currency gain or loss generally will be treated as U.S. source ordinary income or loss for foreign tax credit limitation purposes.

Dividends will be income from sources outside the United States, and generally will be “passive category” income or, for certain taxpayers, “general category” income, which are treated separately from each other for the purpose of computing the foreign tax credit allowable to a U.S. holder. The availability of the foreign tax credit and the application of the limitations on its availability are fact specific and are subject to complex rules. In general, a taxpayer’s ability to use foreign tax credits may be limited and is dependent on the particular circumstances. U.S. holders should consult their own tax advisors with respect to these matters.

Sale, Exchange or other Disposition of Ordinary Shares or ADSs

Subject to the PFIC rules discussed below, a U.S. holder who sells or otherwise disposes of ordinary shares or ADSs will recognize a capital gain or loss for U.S. federal income tax purposes equal to the difference between the U.S. dollar value of the amount realized and the holder’s tax basis, determined in U.S. dollars, in those ordinary shares or ADSs. The gain or loss will generally be income or loss from sources within the United States for foreign tax credit limitation purposes. The capital gain of a non-corporate U.S. holder is generally taxed at preferential rates where the holder has a holding period greater than 12 months in the shares or ADSs sold. There are limitations on the deductibility of capital losses.

The U.S. dollar value of any foreign currency received upon a sale or other disposition of ordinary shares or ADSs will be calculated by reference to the spot rate in effect on the date of sale or other disposal (or, in the case of a cash basis or electing accrual basis taxpayer, at the spot rate of exchange on the settlement date). A U.S. holder will have a tax basis in the foreign currency received equal to that U.S. dollar amount, and generally will recognize foreign currency gain or loss on a subsequent conversion or other disposal of the foreign currency. This foreign currency gain or loss generally will be treated as U.S. source ordinary income or loss for foreign tax credit limitation purposes. If such foreign currency is converted into U.S. dollars on the date received by the U.S. holder, a cash basis or electing accrual basis U.S. holder should not recognize any gain or loss on such conversion.

Passive Foreign Investment Company

A non-U.S. corporation will be a PFIC for U.S. federal income tax purposes for any taxable year if either:

| • |  | 75% or more of its gross income for such year is “passive income” which for this purpose generally includes dividends, interest, royalties, rents and gains from commodities and securities transactions and gains from assets that produce passive income; or

| • |  | 50% or more of the value of its gross assets (based on an average of the quarterly values of the gross assets) during such year is attributable to assets that produce passive income or are held for the production of passive income.

Passive income does not include rents and royalties derived from the active conduct of a trade or business. If the stock of a non-U.S. corporation is publicly traded for the taxable year, the asset test is applied using the fair market value of the assets for purposes of measuring such corporation’s assets. If we own at least 25% (by value) of the stock of another corporation, we will be treated, for purposes of the PFIC tests, as owning our proportionate share of the other corporation’s assets and receiving our proportionate share of the other corporation’s income for purposes of the PFIC income and asset tests. If the stock of a non-U.S. corporation is publicly-

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traded for the taxable year, the asset test is applied using the fair market value of the assets for purposes of measuring such corporation’s assets. If we were a PFIC in any year during a U.S. holder’s holding period for our ordinary shares or ADSs, we would ordinarily continue to be treated as a PFIC for each subsequent year during which the U.S. holder owned the ordinary shares or ADSs, regardless of whether we continue to meet the tests described above unless (a) we ceased to be a PFIC and (b) the U.S. holder has made a deemed sale election under the PFIC rules which may result in recognition of gain (but not loss), taxable under the PFIC rules described below, without the receipt of any corresponding cash. Based on the composition of our assets and income in the 2023 taxable year, we believe that we were a PFIC for U.S. federal income tax purposes with respect to our 2023 taxable year. However, the determination of PFIC status is a fact-intensive determination that must be made annually at the close of each taxable year applying principles and methodologies that in some circumstances are unclear and subject to varying interpretation. As a result, there can be no assurance that we will be treated as a PFIC for the 2023 taxable year, the 2024 taxable year, current taxable year or any future taxable year. Based on the composition of our assets and income in the 2024 taxable year, if we will not be treated as a PFIC in the 2023 taxable year, we believe that we were not a PFIC for U.S. federal income tax purposes with respect to our 2024 taxable year. However, as stated above, the determination of PFIC status is a fact-intensive determination that must be made annually at the close of each taxable year applying principles and methodologies that in some circumstances are unclear and subject to varying interpretation. As a result, even if we will not be a treated as a PFIC in the 2023 taxable year, there can be no assurance that we will not be treated as a PFIC in the 2024 taxable year, the current year or for any future taxable year. Changes in the nature of our income or assets or a decrease in the trading price of our ordinary shares or ADSs may impact the determination of our PFIC status.

If we are a PFIC, and you are a U.S. holder, then unless you make one of the elections described below, a special tax regime will apply to both (a) any “excess distribution” by us to you (generally, your ratable portion of distributions in any year which are greater than 125% of the average annual distribution received by you in the shorter of the three preceding years or your holding period for our ordinary shares) and (b) any gain realized on the sale or other disposition of the ordinary shares. Under this regime, any excess distribution and realized gain will be treated as ordinary income and will be subject to tax as if (a) the excess distribution or gain had been realized ratably over your holding period, (b) the amount deemed realized in each year had been subject to tax in each year of that holding period at the highest marginal rate for such year (other than income allocated to the current period or any taxable period before we became a PFIC, which would be subject to tax at the U.S. holder’s regular ordinary income rate for the current year and would not be subject to the interest charge discussed below), and (c) the interest charge generally applicable to underpayments of tax had been imposed on the taxes deemed to have been payable in those years. In addition, dividend distributions made to you will not qualify for the lower rates of taxation applicable to long-term capital gains discussed above under “Distributions.”

Certain elections may potentially be used to reduce the adverse impact of the PFIC rules on U.S. holders (“qualifying electing fund”, or QEF) , and “mark-to-market” elections), but these elections may accelerate the recognition of taxable income and may result in the recognition of ordinary income.

The rules described above for excess distributions would not apply to a U.S. holder if the U.S. holder makes a timely QEF election for the first taxable year of the U.S. holding period for ordinary shares and we comply with specified reporting requirements. A timely QEF election for a taxable year generally must be made on or before the due date (as may be extended) for filing the taxpayer’s U.S. federal income tax return for the year. A U.S. holder who makes a QEF election generally must report on a current year basis a pro rata share of our ordinary earnings and net capital gain for any taxable year in which we are a PFIC, whether or not those earnings or gains are distributed. A U.S. holder who makes a QEF election must file a Form 8621 with its annual income tax return. We intend to make available an information statement that will contain the necessary information required for a U.S. holder to make a QEF election with respect to our ordinary shares. We may choose to provide such information on our website.

If a U.S. holder does not make a QEF election for the first taxable year of the U.S. holder’s holding period for ordinary shares during which we are a PFIC, the QEF election will not be treated as timely and the adverse tax regime described above would apply to dispositions of or excess distributions on the ordinary shares. In such case, a U.S. holder may make a deemed sale election whereby the U.S. holder would be treated as if the U.S. holder had sold the ordinary shares in a fully taxable sale at fair market value on the first day of such taxable year in which the QEF election takes effect. Such U.S. holder would be required to recognize any gain on the deemed sale as an excess distribution and pay any tax and interest due on the excess distribution when making the deemed sale election. The effect of such further election would be to restart the U.S. holder’s holding period in the ordinary shares, subject to the QEF regime, and to purge the PFIC status of such ordinary shares going forward.

If a U.S. holder makes the mark-to-market election with respect to ordinary shares, the U.S. holder generally will recognize as ordinary income any excess of the fair market value of the ordinary shares at the end of each taxable year over their adjusted tax basis, and will recognize an ordinary loss in respect of any excess of the adjusted tax basis of the ordinary shares over their fair market value at the end of the taxable year (but only to the extent of the net amount of income previously included as a result of the mark-to-market election). If a U.S. holder makes the election, the U.S. holder’s tax basis in the ordinary shares will be adjusted to reflect these income or loss amounts. Any gain recognized on the sale or other disposition of ordinary shares in a year when we are a PFIC will be treated as ordinary income and any loss will be treated as an ordinary loss (but only to the extent of the net amount of income previously included as a result of the mark-to-market election). The mark-to-market election is available only if we are a PFIC and our ordinary shares are “regularly traded” on a “qualified exchange”. Our ordinary shares will be treated as “regularly traded” in any calendar year in which more than a de minimis quantity of the ordinary shares are traded on a qualified exchange on at least 15 days during each

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calendar quarter (subject to the rule that trades that have as one of their principle purposes the meeting of the trading requirement as disregarded). The Nasdaq is a qualified exchange for this purpose and consequently, if the ordinary shares are regularly traded, the mark-to-market election should be available to a U.S. holder.

U.S. holders should consult their tax advisors to determine whether any of these elections would be available and if so, what the consequences of the alternative treatments would be in their particular circumstances.

If we are a PFIC, the general tax treatment for U.S. holders described in this section would apply to indirect distributions and gains deemed to be realized by U.S. holders in respect of any of our subsidiaries that also may be determined to be PFICs.

If a U.S. holder owns ordinary shares during any year in which we are a PFIC and the U.S. holder recognizes gain on a disposition of our ordinary shares or receives distributions with respect to our ordinary shares, the U.S. holder generally will be required to file an IRS Form 8621 (Information Return by a Shareholder of a Passive Foreign Investment Company or Qualified Electing Fund) with respect to the company, generally with the U.S. holder’s federal income tax return for that year. If our company were a PFIC for a given taxable year, then you should consult your tax advisor concerning your annual filing requirements.

The U.S. federal income tax rules relating to PFICs are complex. Prospective U.S. investors are urged to consult their tax advisers with respect to the ownership and disposition of our ordinary shares or ADSs, the consequences to them of an investment in a PFIC, any elections available with respect to our ordinary shares and the IRS information reporting obligations with respect to the ownership and disposition of our ordinary shares or ADSs.

U.S. Information Reporting and Back-up Withholding

Dividend payments with respect to our ordinary shares or ADSs and proceeds from the sale or other disposition of our ordinary shares or ADSs may be subject to information reporting to the IRS and possible U.S. backup withholding. Back-up withholding will not apply, however, to a U.S. holder who furnishes a correct taxpayer identification number and makes any other required certification or who is otherwise exempt from back-up withholding. U.S. holders who are required to establish their exempt status may be required to provide such certification on Internal Revenue Service (“IRS”) Form W-9. U.S. holders should consult their tax advisors regarding the application of the U.S. information reporting and back-up withholding rules.

Back-up withholding is not an additional tax. Amounts withheld as back-up withholding may be credited against a U.S. holder’s U.S. federal income tax liability, and such holder may obtain a refund of any excess amounts withheld under the back-up withholding rules by timely filing the appropriate claim for refund with the IRS and furnishing any required information.

Information With Respect to Foreign Financial Assets

Certain U.S. holders that own “specified foreign financial assets” with an aggregate value in excess of $50,000 are generally required to file an information statement along with their U.S. federal tax returns, currently on IRS Form 8938, with respect to such assets. “Specified foreign financial assets” include any financial accounts held at a non-U.S. financial institution, as well as securities issued by a non-U.S. issuer that are not held in accounts maintained by financial institutions. If a U.S. holder does not include in such holder’s gross income an amount relating to one or more specified foreign financial assets, and the amount such U.S. holder omits is more than $5,000, any tax such U.S. holder owes for the tax year can be assessed at any time within 6 years after the filing of such U.S. holder’s federal tax return. U.S. holders who fail to report the required information could be subject to substantial penalties. U.S. holders are encouraged to consult with their own tax advisors regarding the possible application of the foregoing to our ordinary shares or ADSs in light of their particular circumstances.

Australian Tax Considerations

In this section, we discuss the material Australian income tax, stamp duty and goods and services tax considerations related to the acquisition, ownership and disposal by the absolute beneficial owners of the ordinary shares or ADSs.

It is based upon existing Australian tax law as of the date of this registration statement, which is subject to change, possibly retrospectively. This discussion does not address all aspects of Australian tax law which may be important to particular investors in light of their individual investment circumstances, such as shares held by investors subject to special tax rules (for example, financial institutions, insurance companies, superannuation funds, trusts or tax-exempt organizations). In addition, this summary does not discuss any foreign or state tax considerations, other than stamp duty.

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Prospective investors are urged to consult their tax advisors regarding the Australian and foreign income and other tax considerations of the acquisition, ownership and disposition of the shares. Unless otherwise mentioned, this summary is based upon the premise that the holder is not an Australian tax resident holds their shares on capital account for Australian tax purposes, and is not carrying on business in Australia through a permanent establishment (referred to as a “Non-Australian Shareholder” in this summary).

Australian Income Tax

Nature of ADSs for Australian Taxation Purposes

Ordinary shares represented by ADSs held by a U.S. holder will be treated for Australian taxation purposes as held under a “bare trust” for such holder. Consequently, the underlying ordinary shares will be regarded as owned by the ADS holder for Australian income tax and capital gains tax purposes. Dividends paid on the underlying ordinary shares will also be treated as dividends paid to the ADS holder, as the person beneficially entitled to those dividends. Therefore, in the following analysis we discuss the tax consequences to Non-Australian Shareholders which, for Australian taxation purposes, will be the same as to U.S. holders of ADSs.

Taxation of Dividends

Australia operates a dividend imputation system under which dividends may be declared to be “franked” to the extent of tax paid on company profits. Fully franked dividends are not subject to dividend withholding tax. Dividends payable to Non-Australian Shareholders will be subject to dividend withholding tax, to the extent the dividends are not declared to be conduit foreign income, or CFI, and are unfranked. Dividend withholding tax will be imposed at 30%, unless a shareholder is a resident of a country with which Australia has a double taxation agreement and qualifies for the benefits of the treaty. In accordance with the provisions of the Double Taxation Convention between Australia and the United States, the maximum rate of Australian withholding tax on any unfranked portion of a dividend to which a tax resident of the United States is beneficially entitled may be reduced to 15%, with a potential further reduction to 5% where the U.S. resident beneficially entitled to the dividends is a company which holds directly 10% or more of the voting power in our company. To rely on the Double Taxation Convention a U.S. tax resident must also be a “qualified person” within the meaning of the Double Taxation Convention. Shareholders seeking to rely on the Double Taxation Convention should obtain specialist taxation advice.

Tax on Sales or other Dispositions of Shares-Capital Gains Tax

Non-Australian Shareholders may disregard the whole of the capital gain or capital loss made on a sale or other disposal of ordinary shares, unless they, together with any associates (as defined in Australian tax law), hold 10% or more of our issued capital at the time of disposal or throughout a 12 months period during the 24 months prior to disposal.

Non-Australian Shareholders who own a 10% or more interest in the company, either alone or together with their associates, should be subject to Australian capital gains tax if more than 50% of the company’s assets held directly or indirectly, determined by reference to market value of the assets at the time of sale, consists of Australian real property (which includes land and leasehold interests) or Australian mining, quarrying or prospecting rights. The Double Taxation Convention between the United States and Australia is unlikely to limit the amount of this taxable gain. Australian capital gains tax applies to net capital gains of foreign shareholders at the Australian tax rates for non-Australian residents, which start at a marginal rate of 32.5% for individuals & 25%-30% for companies, depending on the size of the company. Net capital gains of foreign shareholders are included in the taxpayer’s assessable income and subject to income tax at the taxpayer’s marginal tax rate. For the year ended 30 June 2025, the marginal tax rates for non-Australian residents, starts at 30% for individuals. The company tax rate is 30% which may be reduced to 25% for the year ended 30 June 2023 onwards for certain small businesses. Net capital gains are calculated by reducing the taxpayer’s capital gains for the income year by its capital losses, which may only be offset against capital gains. Net capital losses may be carried forward to offset against capital gains derived in future income years. Specific loss recoupment rules apply to companies and trusts. These rules may, among other things, limit the ability to offset or obtain capital losses in a current or future income year. Shareholders should obtain specialist tax advice as to how these rules apply.

The 50% capital gains tax discount is not available to Non-Australian Shareholders. Companies are not entitled to a capital gains tax discount.

Broadly, where there is a disposal of certain taxable Australian property, the purchaser will be required to withhold and remit to the Australian Taxation Office (“ATO”) 12.5% of the proceeds from the sale. A transaction is excluded from the withholding requirements in certain circumstances, including where the market value of the taxable Australian property is less than A$750,000, the transaction is an on-market transaction conducted on an approved stock exchange, the transaction is in a category of certain securities lending

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arrangements, or the transaction is conducted using an eligible broker operated crossing system. There is also an exception to the requirement to withhold where the entity selling the shares provides the purchaser a declaration covering a certain period specifying either that they are an Australian tax resident or that the shares are not taxable Australian property (specifically, not ‘indirect Australian real property interests’). The Non-Australian Shareholder may be entitled to receive a tax credit for the tax withheld by the purchaser which they may claim in their Australian income tax return. For completeness, the Treasury Laws Amendment (2024 Tax and Other Measures No. 1) Bill 2024, currently before the House of Representatives, proposes to increase the withholding rate from 12.5% to 15%, and remove the $750,000 threshold. These amendments are intended to apply to relevant CGT assets acquired on or after the later of either 1 January 2025 or the enactment of the bill. The progress of this bill should be monitored to confirm it is enacted in its current form.

Tax on Sales or other Dispositions of Shares-Shareholders Holding Shares on Revenue Account

Some Non-Australian Shareholders may hold ordinary shares on revenue rather than on capital account for example, share traders, or those who hold their shares with a view to deriving a short term profit by selling their shares. These shareholders may have the gains made on the sale or other disposal of the ordinary shares and/or warrants included in their assessable income under the ordinary income provisions of the income tax law, if the income is derived directly or indirectly from Australian sources (which is a question of facts and circumstances generally requiring specialist tax advice).

Non-Australian Shareholders assessable under these ordinary income provisions should be subject to income tax in Australia starting at a marginal rate of 30% for individuals. The company tax rate is 30% which may be reduced to 25% for the year ended 30 June 2023 onwards for certain small businesses. Some relief from Australian income tax may be available to Non-Australian Shareholders under the Double Taxation Convention between the United States and Australia.

To the extent an amount would be included in a Non-Australian Shareholder’s assessable income under both the capital gains tax provisions and the ordinary income provisions, the capital gain amount may be reduced, so that the shareholder may not be subject to double tax on any part of the income gain or capital gain.

Non-Australian Shareholders holding shares on revenue account should obtain advice on the application of the Australian income tax law and the Double Taxation Convention in determining the tax consequences of the disposal of their shares.

The comments above in “Tax on Sales or Other Dispositions of Shares-Capital Gains Tax” regarding a purchaser being required to withhold 12.5% (potentially increasing to 15% from 1 January 2025 – see above) tax on the acquisition of certain taxable Australian property equally applies where the disposal of the Australian real property asset by a foreign resident is likely to generate gains on revenue account, rather than a capital gain.

Dual Residency

If a shareholder is a resident of both Australia and the United States under those countries’ domestic taxation laws, that shareholder may be subject to tax as an Australian resident. If, however, the shareholder is determined to be a U.S. resident for the purposes of the Double Taxation Convention between the United States and Australia, the Australian tax may be subject to limitation by the Double Taxation Convention (albeit the tie-breaker rules only apply for individuals). Shareholders should obtain specialist taxation advice in these circumstances.

Stamp Duty

No Australian stamp duty is payable by Australian residents or non-Australian residents on the issue, transfer and/or surrender of the ADSs or the ordinary shares in Kazia, provided that the shares issued, transferred and/or surrendered do not represent 90% or more of the issued shares in Kazia.

Australian Death Duty

Australia does not have estate or death duties. As a general rule, no capital gains tax liability is realized upon the inheritance of a deceased person’s shares. The disposal of inherited shares by beneficiaries may, however, give rise to a capital gains tax liability if the gain falls within the scope of Australia’s jurisdiction to tax.

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Goods and Services Tax

The supply of ADSs or ordinary shares in Kazia will not be subject to Australian goods and services tax.

F. Dividends and paying agents

Not applicable.

G. Statement by experts

Not applicable.

H. Documents on Display

The Company is subject to the reporting requirements of the Exchange Act that are applicable to a foreign private issuer. Under the Exchange Act, the Company is required to file periodic reports and other information with the SEC. These materials, including this Annual Report and the exhibits hereto, may be inspected without charge and copied at established rates at the public reference facilities maintained by the SEC at 100 F Street, N.E., Washington, D.C., 20549. Please call the SEC at 1-800-SEC-0330 to obtain information on the operation of the public reference room. Such materials can also be obtained at the SEC’s website at www.sec.gov.

I. Subsidiary Information

Not applicable.

Item 11. | Quantitative and Qualitative Disclosures about Market Risk

Interest rate risk

The Company’s exposure to market interest rates relates primarily to the investments of cash balances. The Company has cash reserves held in both Australian dollars and U.S. dollars, and places funds on deposit with financial institutions for periods generally not exceeding three months.

Credit risk

The Company places its deposits with high credit quality financial institutions, and, by policy, limits the amount of credit exposure to any single counterparty. The Company is averse to principal loss and ensures the safety and preservation of its invested funds by limiting default risk, market risk and reinvestment risk. The Company mitigates default risk by depositing funds with only the safest and highest credit quality financial institutions and by constantly positioning its portfolio to respond appropriately to a significant reduction in a credit rating of any financial institution.

The Company has no interest rate exposure due to rate changes for long-term debt obligations. The Company primarily enters into debt obligations to support general corporate purposes, including capital expenditures and working capital needs. The Company does not consider the effects of interest rate movements to be a material risk to its financial condition.

For additional disclosure regarding interest rate risk see Item 18. “Financial Statements - Note 25 - Financial Instruments”.

Foreign currency risk

The Company operates internationally and is exposed to foreign exchange risk arising from various currency exposures, primarily with respect to the U.S. dollar. Foreign exchange risk arises from future transactions and recognized assets and liabilities denominated in a currency that is not the entity’s functional currency and net investments in foreign operations.

As of 30 June 2024, the Company did not hold derivative financial instruments in managing its foreign currency, however, the Company may from time to time enter into hedging arrangements where circumstances are deemed appropriate. The Company used natural hedging to reduce the foreign currency risk, which involved processing U.S. Dollar (“USD”) payments from cash held in USD. Foreign subsidiaries with a functional currency of Australian Dollar (“AUD”) have exposure to the local currency of these subsidiaries and any other currency these subsidiaries trade in.

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For additional disclosure regarding market risk see Item 18. “Financial Statements - Note 25 - Financial Instruments”.

Item 12. | Description of Securities Other than Equity Securities

A. Debt Securities

Not applicable.

B. Warrants and Rights

Not applicable.

C. Other Securities

Not applicable.

D. American Depositary Shares

The depository for the Company’s American Depository Shares (“ADSs”) is the Bank of New York Mellon, located at 240 Greenwich Street, New York, NY 10286. The depository collects its fees for delivery and surrender of American Depository Shares directly from investors depositing shares or surrendering ADSs for the purpose of withdrawal or from intermediaries acting for them. The depository collects fees for making distributions to investors by deducting those fees from the amounts distributed or by selling a portion of distributable property to pay the fees. The depository may collect its annual fee for depository services by deductions from cash distributions or by directly billing investors or by charging the book-entry system accounts of participants acting for them. The depository may generally refuse to provide fee-attracting services until its fees for those services are paid. The depository may collect any of its fees by deduction from any cash distribution payable to you that are obligated to pay those fees.

From time to time, the depository may make payments to us to reimburse or share revenue from the fees collected from you, or waive fees and expenses for services provided, generally relating to costs and expenses arising out of establishment and maintenance of the ADS program. In performing its duties under the deposit agreement, the depository may use brokers, dealers or other service providers that are affiliates of the depository and that may earn or share fees or commissions.

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Persons depositing or withdrawing shares must pay: |  | For:
US$5.00 (or less) per 100 ADSs (or portion of 100 ADSs) |  | •   Issuance of ADSs, including issuances resulting from a distribution of shares or rights or other property
|  | •   Cancellation of ADSs for the purpose of withdrawal, including if the deposit agreement terminates
US$.05 (or less) per ADS |  | •   Any cash distribution to ADS registered holders
A fee equivalent to the fee that would be payable if securities distributed to you had been shares and the shares had been deposited for issuance of ADSs |  | •   Distribution of securities distributed to holders of deposited securities which are distributed by the depositary to ADS registered holders
US$.05 (or less) per ADSs per calendar year |  | •   Depositary services
Registration or transfer fees |  | •   Transfer and registration of shares on the Company’s share register to or from the name of the depositary or its agent when you deposit or withdraw shares
Expenses of the depositary |  | •   Cable, telex and facsimile transmissions (when expressly provided in the deposit agreement)
|  | •   Converting foreign currency to U.S. dollars
Taxes and other governmental charges the depositary or the custodian have to pay on any ADS or share underlying an ADS, for example, stock transfer taxes, stamp duty or withholding taxes |  | •   As necessary
Any charges incurred by the depositary or its agents for servicing the deposited securities |  | •   As necessary

The Depositary may collect any of the fees by deduction from any cash distribution payable, or by selling a portion of any securities to be distributed, to holders that are obligated to pay those fees.

See Exhibit 2.2 “Description of Securities” for additional information on the ADSs.

PART II

Item 13. | Defaults, Dividend Arrearages and Delinquencies

This item is not applicable.

Item 14. | Material Modifications to the Rights of Security Holders and the Use of Proceeds

This item is not applicable.

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Item 15. | Controls and Procedures

(a) Disclosure controls and procedures

We maintain “disclosure controls and procedures,” as this term is defined in Rules 13a-15(e) and 15d-15(e) under the Exchange Act, that are designed to provide reasonable assurance that information required to be disclosed by us in reports that we file or submit under the Exchange Act is recorded, processed, summarized, and reported within the time periods specified in the Securities and Exchange Commission’s (“SEC”) rules and forms, and that such information is accumulated and communicated to our management, including our Chief Executive Officer and Vice President of Finance and Controller, as appropriate, to allow timely decisions regarding required disclosure. Our Chief Executive Officer, Vice President of Finance and Controller and Chief Financial Officer recognize that these controls, no matter how well designed and operated, cannot provide absolute assurance that the objectives of these controls will be met.

Our management, with the participation of our Chief Executive Officer, and Vice President of Finance and Controller , has evaluated the effectiveness of the design and operation of our disclosure controls and procedures as of 30 June 2024. Based upon that evaluation, our Chief Executive Officer, and Vice President of Finance and Controller concluded that the controls and procedures were effective as of 30 June 2024 to ensure that material information was accumulated and communicated to our management as appropriate to allow timely decisions regarding required disclosure.

(b) Management’s annual report on internal control over financial reporting

The management of Kazia Therapeutics Limited is responsible for establishing and maintaining adequate internal control over financial reporting as defined in Rules 13a-15(f) under the Exchange Act. Under the supervision and with the participation of our management, including our Chief Executive Officer, and Vice President of Finance and Controller we conducted an evaluation of the effectiveness of our internal control over financial reporting as of 30 June 2024, based on the criteria set forth in Internal Control Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission (COSO 2013). Based on that evaluation, management concluded that our internal control over financial reporting was effective as of 30 June 2024. Kazia Therapeutics Limited’s internal control over financial reporting was designed to provide reasonable assurance to the Company’s management and Board of Directors regarding the preparation and fair presentation of published financial statements. All internal control systems, no matter how well designed, have inherent limitations. Therefore, even those systems determined to be effective can provide only reasonable assurance with respect to financial statement preparation and presentation.

Remediation of Previously Reported Material Weakness

During the year ended 30 June 2024, the Company completed its efforts to remediate the material weakness identified in 2023 in our controls over initial accounting of new significant transactions. Upon completion of those efforts, the Company concluded that the material weakness had been remediated as of 30 June 2024. As part of those remediation efforts, the Company implemented remediation actions during 2024 that included seeking external professional accounting advice about the initial accounting of new significant transactions.

(c) Attestation Report of the Registered Public Accounting Firm

Not applicable.

(d) Changes in Internal Control over Financial Reporting

Other than the changes intended to remediate material weakness noted above, no change in our internal control over financial reporting (as defined in Rules 13a-15(f) and 15d-15(f) under the Exchange Act) occurred during the year ended 30 June 2024 that has materially affected, or is reasonably likely to materially affect, our internal control over financial reporting.

Item 16. | [Reserved]

Item 16A. | Audit Committee Financial Expert

(1) | The board of directors has determined that the Company:

| (i) | Has one audit committee financial expert serving on its audit committee

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(2) | Steven Coffey is the audit committee expert and is independent, as that term is defined in the listing standards applicable to the registrant if the registrant is a listed issuer, as defined in 17 CFR 240.10A-3. Steven Coffey meets the independence requirements of the Nasdaq Capital Market and SEC’s rules and regulations as he is a qualified Chartered Accountant and has spent over 30 years in public practice. He is also a registered company auditor.

Item 16B. | Code of Ethics

The Company has adopted a Code of Ethics and Business Conduct (the “Code”). The Code establishes a clear set of values that emphasize a culture encompassing strong corporate governance, sound business practices and good ethical conduct. The Code confirms the Company’s belief in treating all individuals with respect and recognizes that different skills and diversity are essential to enrich the Company’s perspective, improve corporate performance, increase shareholder value and maximize the achievement and goals of the Company. The Code applies to all Company employees, including management and Directors. The Code is available on the Company’s website www.kaziatherapeutics.com.

Item 16C. | Principal Accounting Fees and Services

BDO Audit Pty Ltd (“BDO”) has audited the Company’s annual financial statements acting as the independent registered public accounting firm for the fiscal year ended 30 June 2024.

The table below set forth the total fees for services performed by BDO in fiscal years 2024 and 2023 and summarizes these amounts by the category of service.

|  | 2024 A$ |  |  | 2023 A$ |
Audit services - BDO Audit Pty Ltd |  |  |  |  |  |  |  |
Audit or review of the financial statements |  |  | 418,039 |  |  |  | 292,772 |
Other services BDO Audit Pty Ltd |  |  | — |  |  |  | — |
Comfort letters |  |  | 28,774 |  |  |  | 18,000 |
Consent letter - F-1 |  |  | 104,687 |  |  |  | — |
Consent letter - F-3 |  |  | 11,199 |  |  |  | — |
|  |  | 562,699 |  |  |  | 310,772 |

Audit fees

The audit fees include the aggregate fees incurred in fiscal years 2024 and 2023 for professional services rendered in connection with the audit of the Company’s annual financial statements and for related services that are reasonably related to the performance of the audit or services that are normally provided by the auditor in connection with regulatory filings of engagements for those financial years (including review of the Company’s Annual Report on Form 20-F, consents and other services related to SEC matters).

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Pre-approval policies and procedures

The Audit Committee Charter sets forth the Company’s policy regarding the appointment of independent auditors. The Audit Committee Charter also requires the Audit Committee to review and approve in advance the appointment of the independent auditors for the performance of 100% of all audit services and, after taking into account the opinion of management, 100% of lawfully permitted non-audit services. The Audit Committee may delegate authority to one or more members of the Audit Committee where appropriate, but no such delegation is permitted if the authority is required by law, regulation or listing standard to be exercised by the Audit Committee as a whole.

Item 16D. | Exemptions from the Listing Standards for Audit Committees

This item is not applicable.

Item 16E. | Purchases of Equity Securities by the Issuer and Affiliated Purchasers

This item is not applicable.

Item 16F. | Changes in registrant’s Certifying Accountant

This item is not applicable.

Item 16G. | Corporate Governance

Implications of Being a Foreign Private Issuer

We are also considered a “foreign private issuer.” In our capacity as a foreign private issuer, we are exempt from certain rules under the U.S. Securities Exchange Act of 1934, as amended (the “Exchange Act”), that impose certain disclosure obligations and procedural requirements for proxy solicitations under Section 14 of the Exchange Act. In addition, our officers, directors and principal shareholders are exempt from the reporting and “short-swing” profit recovery provisions of Section 16 of the Exchange Act and the rules under the Exchange Act with respect to their purchases and sales of our ordinary shares. Moreover, we are not required to file periodic reports and financial statements with the SEC as frequently or as promptly as U.S. companies whose securities are registered under the Exchange Act. In addition, we are not required to comply with Regulation FD, which restricts the selective disclosure of material information.

Exemptions from Certain Corporate Governance Rules of the Nasdaq Stock Market, LLC

Exemptions from the corporate governance standards of the Nasdaq Stock Market, LLC (“Nasdaq”) are available to foreign private issuers such as Kazia when those standards are contrary to a law, rule or regulation of any public authority exercising jurisdiction over such issuer or contrary to generally accepted business practices in the issuer’s country of domicile. In connection with Kazia’s National Market Listing Application, Nasdaq granted Kazia exemptions from certain corporate governance standards that were contrary to the laws, rules, regulations or generally accepted business practices of Australia. These exemptions and the practices followed by Kazia are described below:

| • |  | Kazia is exempt from Nasdaq’s requirement that each Nasdaq issuer shall require shareholder approval of a plan or arrangement in connection with the acquisition of the stock or assets of another company if “any director, officer or substantial shareholder of the issuer has a 5 percent or greater interest (or such persons collectively have a 10 percent or greater interest), directly or indirectly, in the company or assets to be acquired or in the consideration to be paid in the transaction or series of related transactions and the present or potential issuance of common stock, or securities convertible into or exercisable for common stock, could result in an increase in outstanding common shares or voting power of 5 percent or more”. The Corporations Act to which Kazia is also subject generally requires shareholder approval for a transaction with a director or director-controlled entity unless on arm’s length terms.

| • |  | Nasdaq requirement under Rule 5620(c) that a quorum consist of holders of 33 1/3% of the outstanding ordinary shares. Our quorum is currently three shareholders. We believe this quorum requirement is generally appropriate and typical of generally accepted business practices in Australia.

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| • |  | Nasdaq requirements under Rules 5605(b)(1) and (2) relating to director independence, including the requirements that a majority of the board of directors must be comprised of independent directors and that independent directors must have regularly scheduled meetings at which only independent directors are present. The Corporations Act does not impose any mandatory requirements on director independence or the number of independent directors required for an Australian company. However, in performing their role, directors of Australian companies are subject to a range of duties and obligations under the Corporations Act, the common law and a company’s constitution, which indirectly regulate directors’ independence (including in respect of managing conflicts of interest). We believe that our Board composition is consistent with the requirements of the Corporations Act and that it is appropriate and typical of generally accepted business practices in Australia.

| • |  | The requirement that our independent directors meet regularly in executive sessions under Nasdaq Listing Rules. The Corporations Act does not require the independent directors of an Australian company to have such executive sessions.

| • |  | The Nasdaq requirements under Rules 5605(d) and 5605(e) that compensation of an issuer’s officers must be determined, or recommended to the Board for determination, either by a majority of the independent directors, or a compensation committee comprised solely of independent directors, and that director nominees must either be selected, or recommended for the Board’s selection, either by a majority of the independent directors, or a nominations committee comprised solely of independent directors. The reasonable remuneration of officers of a public company is an exception under the Corporations Act to the requirement to obtain shareholder approval for related party benefits. Accordingly, the Corporations Act does not generally impose mandatory requirements in respect of the remuneration of officers of Australian companies which are not listed on financial markets operating in Australia. However, the replaceable rules (which do not apply in relation to Kazia) provide that directors are to be paid the remuneration that a company determines by resolution. This is largely reflective of accepted business practices in Australia and largely aligns with our Constitution, which provides that:

| • |  | Kazia in general meeting may from time to time determine the maximum aggregate remuneration to be provided to or for the benefit of its non-executive directors for services rendered as non-executive directors (“Remuneration”) and until a different amount is determined, the amount of Remuneration is $560,000 per annum; and

| • |  | the directors may divide the Remuneration among themselves in any proportions and in any manner as they may from time to time determine. If the directors do not or are unable to make a determination as to the apportionment of the Remuneration, it must be divided among them equally.

Despite its delisting from the ASX, for good corporate governance, Kazia has, and expects to continue to have, a Remuneration and Nomination Committee consisting of three non-executive directors.

| • |  | The requirement prescribed by Nasdaq Listing Rules that issuers obtain shareholder approval prior to the issuance of securities in connection with certain acquisitions, private placements of securities, or the establishment or amendment of certain share option, purchase or other compensation plans. Applicable Australian law differs from Nasdaq requirements, with the Corporations Act not explicitly requiring shareholder approval for these types of matters, unless certain other triggers are met for example where the issuance is made to a related party (and no exceptions apply)). However, under Australian law, the constituent documents of a company may list other circumstances in which shareholder approval is required, and this can extend to circumstances concerning the issuance of securities in connection with certain acquisitions, private placements of securities, or the establishment or amendment of certain share option, purchase or other compensation plans. Our Constitution does not contain such restrictions.

Item 16H. | Mine Safety Disclosure

This item is not applicable.

Item 16I. | Disclosure Regarding Foreign Jurisdictions that Prevent Inspections

Not Applicable.

Item 16J. | Insider trading policies

The Company has adopted a Securities Trading Policy that governs the purchase, sale, and other dispositions of the the Company’s securities by directors, senior management, and employees that are reasonably designed to promote compliance with applicable insider trading laws, rules and regulations, and any listing standards applicable to the registrant. A copy of the Company’s Securities Trading Policy is filed as Exhibit 11.1 hereto.

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Item 16K. | Cybersecurity

Cybersecurity Risk Management and Strategy

We operate in the biotechnology sector, which is subject to various cybersecurity risks that could adversely affect our business, financial condition, and results of operations, including intellectual property theft; fraud; extortion; harm to employees; violation of privacy laws and other litigation and legal risk; and reputational risk. We recognize the importance of developing, implementing, and maintaining cybersecurity measures to safeguard our information systems and protect the confidentiality, integrity, and availability of our data. We have adopted and maintain a cybersecurity risk management program, in accordance with our risk profile and business, that is informed by industry standards.

We implement various cybersecurity tools and technologies, including multi-factor authentication, and the establishment of an incident response plan, to help protect our systems from cybersecurity threats. We also engage a third-party service provider to help us assess and identify cybersecurity risks to our information systems. Further, with help from our third party consultant, we will be conducting a cybersecurity risk assessment and then adapt recommendations from this assessment into our cyber risk strategy.

To date, we have not identified any cybersecurity incidents which have materially affected, or are reasonably likely to materially affect, our business strategy, results of operations or financial condition. However, like other companies in our industry, we and our third-party vendors may from time to time experience threats and other security events that could affect our information or systems. For more information, please see the section entitled “Risk Factors” in this Annual Report on Form 20-F.

Governance

Our Chief Executive Officer (“CEO”) and Vice President of Finance and Controller (“VP of Finance”) are principally responsible for overseeing the day-to-day management of the Company’s cybersecurity risk management program. The individual currently serving as the VP of Finance maintains approximately 20 years of experience in advising on risk management, including on the management of risks relating to cybersecurity. The VP of Finance will receive additional technical support in managing cybersecurity risk from our third-party consultant.

The Company’s Audit Committee, which reports directly to the board of directors, in conjunction with management, oversees the assessment of the Company’s risk management program including the prevention and mitigation of cybersecurity risk. The Company’s Audit Committee receives updates from the CEO with respect to risk management, including the management of risks from cybersecurity threats.

PART III

Item 17. | Financial Statements

Refer to “Item 18 – Financial Statements” below.

Item 18. | Financial Statements

The consolidated financial statements filed as part of this Annual Report commencing on page F-1.

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Item 19. | Exhibits

(a) Exhibits

1.1 |  | Constitution of Kazia Therapeutics Limited, as amended and restated on November 16, 2022 (incorporated by reference to Exhibit 3.1 to the Company’s Registration Statement on Form F-1 filed with the SEC on January 31, 2024).
2.1 |  | Amended and Restated Deposit Agreement, dated as of June 13, 2016 among Novogen Limited, The Bank of New York, as Depositary, and owners and holders from time to time of ADSs issued thereunder (incorporated by reference to Exhibit 2.1 to the Company’s Annual Report on Form 20-F filed with the SEC on October 27, 2016 (File No. 0-29962)).
2.2* |  | Description of Securities
2.3 |  | Form of Warrant to purchase Ordinary Shares represented by American Depositary Shares (incorporated by reference to Exhibit 4.2 to the Form 6-K filed by the Company with the SEC on December 6, 2023).
2.4 |  | Form of Placement Agent Warrant to purchase Ordinary Shares represented by American Depositary Shares (incorporated by reference to Exhibit 4.3 to the Form 6-K filed by the Company with the SEC on December 6, 2023).
2.5 |  | Form of Warrant to repurchase Ordinary Shares represented by American Depositary Shares (incorporated by reference to Exhibit 4.1 to the Form 6-K filed by the Company with the SEC on April 19, 2024)
4.1 |  | Lease Agreement, dated November 1, 2015 between Coal Services Pty Limited and Novogen (incorporated by reference to Exhibit 4.1 to the Company’s Annual Report on Form 20-F filed with the SEC on October 27, 2016 (File No. 0-29962)).
4.2 |  | Convertible Note Deed Poll with Triaxial Pty Ltd Noteholders dated December 6, 2012 (incorporated by reference to Exhibit 4.6 to the Company’s Annual Report on Form 20-F filed with the SEC on October 27, 2016 (File No. 0-29962)).
4.3 |  | Amendment to Convertible Note Deed Poll with Triaxial Pty Ltd Noteholders dated December 4, 2014 (incorporated by reference to Exhibit 4.7 to the Company’s Annual Report on Form 20-F filed with the SEC on October 27, 2016 (File No. 0-29962)).
4.4 |  | Kazia Therapeutics Officers’ and Employees’ Share Option Plan (incorporated by reference to Exhibit 4.10 to the Company’s Annual Report on Form 20-F filed with the SEC on October 27, 2016 (File No.0-29962)).
4.5 |  | Share Sale Agreement dated October 31, 2016 between Kilinwata Investments Pty. Ltd., Mi Ok Chong, Paul Hopper and Novogen Limited (Incorporated by reference to Exhibit 4.11 to the Company’s Annual Report on Form 20-F filed with the SEC on October 25, 2017 (File No. 0-29962)).
4.6 |  | Exclusive License Agreement dated October 25, 2016 between Genentech, Inc. and Novogen Limited (incorporated by reference to Exhibit 4.12 to the Company’s Annual Report on Form 20-F filed with the SEC on October 25, 2017 (File No. 0-29962)).
4.7 |  | Sabio Solutions Pty Limited Letter of Appointment – Company Secretary, dated as of September 1, 2016 (incorporated by reference to Exhibit 4.17 to the Company’s Annual Report on Form 20-F filed with the SEC on October 25, 2017 (File No. 0-29962)).
4.8 |  | Sabio Solutions Pty Limited Contract Extension Letter, dated as of March 1, 2017 (incorporated by reference to Exhibit 4.18 to the Company’s Annual Report on Form 20-F filed with the SEC on October 25, 2017 (File No. 0-29962)).
4.9 |  | Sabio Solutions Pty Limited Contract Extension Letter, dated as of August 23, 2017 (incorporated by reference to Exhibit 4.19 to the Company’s Annual Report on Form 20-F filed with the SEC on October 25, 2017 (File No. 0-29962)).
4.1 |  | Investigator Initiated Clinical Trial Agreement between Kazia Therapeutics Limited and Dana-Farber/Partners Cancer Care Inc dated 17 October 2018 (incorporated by reference to Exhibit 4.12 to the Company’s Annual Report on Form 20-F filed with the SEC on October 21, 2019).
4.11 |  | Research Funding and Supply Agreement between Alliance for Clinical Trials in Oncology Foundation and Kazia Therapeutics Limited, dated 11 June 2019 (incorporated by reference to Exhibit 4.13 to the Company’s Annual Report on Form 20-F filed with the SEC on October 21, 2019).
4.12 |  | Master Clinical Trial Agreement between St Jude Children’s Hospital Inc. and Kazia Laboratories Pty Limited dated 17 November 2017 and associated work order date 7 June 2019 (incorporated by reference to Exhibit 4.14 to the Company’s Annual Report on Form 20-F filed with the SEC on October 21, 2019).

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4.13 |  | Memorial Sloan Kettering Cancer Center Investigator-Initiated Clinical Trial Agreement with Kazia Therapeutics Limited dated as 22 July 2019 (incorporated by reference to Exhibit 4.15 to the Company’s Annual Report on Form 20-F filed with the SEC on October 22, 2020).
4.14 |  | Investigator Initiated Clinical Trial Agreement with Kazia Therapeutics Limited Agreement dated as 18 September 2020 (incorporated by reference to Exhibit 4.16 to the Company’s Annual Report on Form 20-F filed with the SEC on October 22, 2020).
4.15 |  | Global Coalition for Adaptive Research, (“GCAR”) Clinical trial collaboration and supply agreement dated as 15 October 2020 (incorporated by reference to Exhibit 4.17 to the Company’s Annual Report on Form 20-F filed with the SEC on October 22, 2020).
4.16 |  | Development and Commercialisation Licence Agreement between Kazia Therapeutics Limited and Oasmia Pharmaceutical AB, dated March 1, 2021. (incorporated by reference to Exhibit 4.18 to the Company’s Annual Report on Form 20-F filed with the SEC on October 7, 2021).
4.17 |  | License Agreement between Kazia Therapeutics Limited and Simcere Pharmaceutical Co., Ltd., dated March 29, 2021 (incorporated by reference to Exhibit 4.19 to the Company’s Annual Report on Form 20-F filed with the SEC on October 7, 2021).
4.18 |  | License Agreement between Kazia Therapeutics Limited and Evotec (France) SAS, dated April 19, 2021.
4.19 |  | Employment agreement between Kazia Therapeutics Inc. and John Friend dated September 20, 2021.
4.20 |  | Addendum to employment agreement between Kazia Therapeutics Inc. and John Friend dated June 7, 2023.
4.21* |  | Employment agreement between Kazia Therapeutics Inc. and Jeffrey Bonacorda dated April 25, 2024.
8.1 |  | Company Subsidiaries (incorporated by reference to Exhibit 8.1 to the Company’s Annual Report on Form 20-F filed with the SEC on October 24, 2018 (File No. 0-299621)).
11.1* |  | Securities Trading Policy
12.1* |  | Certification of Principal Executive Officer pursuant to Rule 13a-14(a) of the Securities Exchange Act of 1934, as amended.
12.2* |  | Certification of Principal Financial Officer pursuant to Rule 13a-14(a) of the Securities Exchange Act of 1934, as amended.
13.1* |  | Certification of Principal Executive Officer and the Principal Financial Officer pursuant to 18 U.S.C. Section 1350 as adopted pursuant to section 906 of the Sarbanes-Oxley Act of 2002.
15.1* |  | Consent of Independent Registered Public Accounting Firm.
15.2* |  | Consent of Independent Registered Public Accounting Firm.
97.1* |  | Compensation Recovery Policy
101.INS* |  | XBRL Instance Document
101.SCH* |  | XBRL Taxonomy Extension Schema Document
101.CAL* |  | XBRL Taxonomy Extension Calculation Linkbase Document
101.DEF* |  | XBRL Taxonomy Extension Definition Linkbase Document
101.LAB* |  | XBRL Taxonomy Extension Label Linkbase Document
101.PRE* |  | XBRL Taxonomy Extension Presentation Linkbase Document
104 |  | Cover Page Interactive Data File (embedded within the Inline XBRL document)

* | Filed herewith.

✓ | Certain confidential information in this exhibit was omitted by means of marking such information with brackets (“[***]”) because the identified confidential information is not material and is the type that the registrant treats as private or confidential.

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SIGNATURES

The registrant hereby certifies that it meets all of the requirements for filing on Form 20-F and that it has duly caused and authorized the undersigned to sign this Annual Report on its behalf.

KAZIA THERAPEUTICS LIMITED
/s/ John Friend
Dr John Friend
Managing Director and Chief Executive Officer
Date: 15 November 2024

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0.01 0.01 2024-01-04 2025-01-13 2024-11-09 2025-01-13 2025-01-04 2026-06-26 2025-11-16 2025-11-16 2025-11-16 2027-02-01 2027-02-01 2027-05-24 2027-03-03 2027-05-03 2027-03-03 2027-05-03 2022-08-07 2023-02-05 2029-04-22 2029-06-17 2025-11-16 2025-11-16 2025-11-16 2027-02-01 2027-02-01 2027-05-24 2024-01-04 2025-01-13 2024-11-09 2025-01-13 2025-01-04 2026-06-26 2030-06-27 2027-03-03 2027-05-03 2029-04-22 2029-06-17 2030-06-27 2025-11-16 2025-11-16 2025-11-16 2027-02-01 2027-02-01 2027-05-24 2024-01-04 2025-01-13 2024-11-09 2025-01-13 2025-01-04 2026-06-26
Index to Financial Statements

|  | Page |
Consolidated Financial Statements for 30 June 2024, 2023, and 2022 and the years then ended: |  |  |  |
Report of Independent Registered Public Accounting Firm (BDO Audit Pty Ltd, Sydney, Australia PCAOB ID:# 02256) |  |  | F- 2 |
Report of Independent Registered Public Accounting Firm (Grant Thornton Audit Pty Ltd, Sydney, Australia PCAOB ID:# 2233) |  |  | F- 5 |
Consolidated Statement of Profit or Loss and Other Comprehensive Income |  |  | F- 6 |
Consolidated Statement of Financial Position |  |  | F- 7 |
Consolidated Statement of Changes in Equity |  |  | F- 8 |
Consolidated Statement of Cash Flows |  |  | F- 9 |
Notes to Consolidated Financial Statements |  |  | F-1 0 |

F-
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Table of Contents
REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
Shareholders and Board of Directors
Kazia Therapeutics Limited
Sydney, Australia, New South Wales
Opinion on the Consolidated Financial Statements
We have audited the accompanying consolidated statements of financial position of Kazia Therapeutics Limited (the ‘Company’) as of June 30, 2024 and 2023, the related consolidated statements of profit or loss and other comprehensive income, changes in equity, and cash flows for each of the years then ended, and the related notes (collectively referred to as the ‘consolidated financial statements’). In our opinion, the consolidated financial statements present fairly, in all material respects, the financial position of the Company as of June 30, 2024 and 2023, and the results of its operations and its cash flows for the years then ended in conformity with International Financial Reporting Standards, as issued by the International Accounting Standards Board.
Substantial doubt about the Company’s ability to continue as a Going Concern
The accompanying consolidated financial statements have been prepared assuming that the Company will continue as a going concern. As described in Note 2 to the consolidated financial statements, the Company has suffered recurring losses from operations and negative cash flows from operations. These conditions, along with other matters set forth in Note 2, raise substantial doubt about the Company’s ability to continue as a going concern. Management’s evaluation of the events and conditions and management’s plans regarding these matters are also described in Note 2. The consolidated financial statements do not include any adjustments that might result from the outcome of this uncertainty. Our opinion is not modified with respect to this matter.
Emphasis of matter - Restatement of comparatives
As discussed in Note 4 and Note 5 to the consolidated financial statements, the 2022 consolidated financial statements have been restated to correct an error and reclassification, respectively.
We also audited the adjustments described in Note 4 to restate and Note 5 to reclassify the 2022 consolidated financial statements to correct an error and reclassification. In our opinion, such adjustments are appropriate and have been properly applied. We were not engaged to audit, review, or apply any procedures to the 2022 consolidated financial statements of the Company other than with respect to the adjustments as described in Note 4 and Note 5 and, accordingly, we do not express an opinion or any other form of assurance on the 2022 consolidated financial statements taken as a whole.
Basis for opinion
These consolidated financial statements are the responsibility of the Company’s management. Our responsibility is to express an opinion on the Company’s consolidated financial statements based on our audits. We are a public accounting firm registered with the Public Company Accounting Oversight Board (United States) (‘PCAOB’) and are required to be independent with respect to the Company in accordance with the U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.
We conducted our audits in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the consolidated financial statements are free of material misstatement, whether due to error or fraud.
The Company is not required to have, nor were we engaged to perform, an audit of its internal control over financial reporting. As part of our audits we are required to obtain an understanding of internal control over financial reporting but not for the purpose of expressing an opinion on the effectiveness of the Company’s internal control over financial reporting. Accordingly, we express no such opinion.
Our audits included performing procedures to assess the risks of material misstatement of the consolidated financial statements, whether due to error or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis, evidence regarding the amounts and disclosures in the consolidated financial statements. Our audits also included evaluating the accounting principles used and significant estimates made by management, as well as evaluating the overall presentation of the consolidated financial statements. We believe that our audits provide a reasonable basis for our opinion.
Critical audit matters
The critical audit matters communicated below are matters arising from the current period audit of the consolidated financial statements that were communicated or required to be communicated to the audit committee and that: (1) relate to accounts or disclosures that are material to the consolidated financial statements and (2) involved our especially challenging, subjective, or complex judgments. The communication of critical audit matters does not alter in any way our opinion on the consolidated financial statements, taken as a whole, and we are not, by communicating the critical audit matters below, providing separate opinions on the critical audit matters or on the accounts or disclosures to which they relate.
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Valuation of contingent consideration
As described in Note 3 and 19 to the consolidated financial statements, the Company has a A$7 million contingent consideration liability recorded as of June 30, 2024 representing the fair value of additional amounts that management believes are likely to be paid to third parties. The determination of the recorded amount of the contingent consideration liabilities requires the Company to make significant estimates and assumptions.
We identified the measurement of the contingent consideration liability as a critical audit matter. The measurement of the contingent consideration liability requires management to determine significant assumptions including estimated probability of achieving milestones, timing of milestones and discount rates. Auditing the Company’s valuation of the contingent consideration liability involved especially challenging and subjective auditor judgment due to the nature and extent of audit effort required to address these matters, including the extent of specialized skill or knowledge needed.
The primary procedures we performed to address this critical audit matter included:

• |  | Assessing the reasonableness of timing and probability of milestone assumptions against: (i) publicly available information, (ii) published clinical trial updates and results, and (iii) review of a sample of contracts.

• |  | Utilizing professionals with specialized skills and knowledge in valuation to assist in assessing the reasonableness of the discount rates applied by management in determining the contingent consideration.

Valuation and classification of prefunded and ordinary warrants
As described in Note 21 to the consolidated financial statements, the Company has a A$6.5 million financial liability recorded as of June 30, 2024 representing the fair value of the prefunded and ordinary warrants. The valuation and classification of the recorded amount of the prefunded warrants and ordinary warrants requires the Company to make significant estimates and assumptions.
We identified the valuation and classification of the prefunded and ordinary warrants as a critical audit matter. The valuation of the prefunded and ordinary warrants requires management to determine significant assumptions including estimated capital to be raised, exercise date, estimated stock price and risk free rate. The classification of the prefunded and ordinary warrants requires management’s judgment in evaluating contractual terms and applying relevant accounting guidance. Auditing the Company’s valuation involved especially challenging and subjective auditor judgment due to the nature and extent of audit effort required to address these matters, including the extent of specialized skill or knowledge needed.
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The primary procedures we performed to address this critical audit matter included:

• |  | Assessing the reasonableness of assumptions used in the managements’ expert valuation report against industry data, a sample of contracts and other relevant evidence.

• |  | Assessing the appropriateness of the classification by reviewing a sample of contracts against relevant accounting guidance.

• |  | Utilizing professionals with specialized skills and knowledge in valuation to assist in assessing the reasonableness of the valuation methodology applied.

/s/ BDO Audit Pty Ltd
We have served as the Company’s auditor since 2023.
Sydney, Australia
November 15, 2024
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REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
Board of Directors and Shareholders
Kazia Therapeuticals Limited
Opinion on the financial statements
We have audited, before the effects of the restatement, due to the correction of an error, as described in Note
4
, and the reclassification, as described in Note 5, the consolidated statement of financial position of Kazia Therapeutics Limited and subsidiaries (the “Company”) as of 30 June 2022, the related consolidated statements of profit or loss and other comprehensive income, changes in shareholders’ equity, and cash flows for the year then ended, and the related notes (collectively referred to as the “financial statements”) (the 2022 financial statements before the effects of the restatement discussed in Note 4 are not presented herein).
In our opinion, the financial statements, which are before the effects of the restatement due to the correction of an error described in Note 4, and the reclassification, as described in Note 5, present fairly, in all material respects, the financial position of the Company as of June 30, 2022, and the results of its operations and its cash flows for the year then ended (the 2022 consolidated financial statements before the effects of the restatement discussed in Note 4 are not presented herein), in conformity with International Financial Reporting Standards, as issued by the International Accounting Standards Board.
We were not engaged to audit, review, or apply any procedures to the restatement due to the correction of an error, as described in Note 4, and the reclassification, as described in Note 5, and accordingly, we do not express an opinion or any other form of assurance about whether such adjustments are appropriate and have been properly applied. Those adjustments were audited by BDO Audit Pty Limited.
Going Concern
The 2022 financial statements have been prepared assuming that the Company will continue as a going concern. As discussed in Note
2
to the 2022 financial statements, the Company has suffered recurring losses from operations and negative cash flow from operations. These conditions, along with other matters as set forth in Note
2
, raise substantial doubt about the Company’s ability to continue as a going concern. Management’s plans in regard to these matters are also described in Note
2
. The financial statements do not include any adjustments that might result from the outcome of this uncertainty.
Basis for opinion
These financial statements are the responsibility of the Company’s management. Our responsibility is to express an opinion on the Company’s financial statements based on our audits. We are a public accounting firm registered with the Public Company Accounting Oversight Board (United States) (“PCAOB”) and are required to be independent with respect to the Company in accordance with the U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.
We conducted our audit in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement, whether due to error or fraud. The Company is not required to have, nor were we engaged to perform, an audit of its internal control over financial reporting. As part of our audit we are required to obtain an understanding of internal control over financial reporting but not for the purpose of expressing an opinion on the effectiveness of the Company’s internal control over financial reporting. Accordingly, we express no such opinion.
Our audit included performing procedures to assess the risks of material misstatement of the financial statements, whether due to error or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis, evidence regarding the amounts and disclosures in the financial statements. Our audit also included evaluating the accounting principles used and significant estimates made by management, as well as evaluating the overall presentation of the financial statements. We believe that our audit provide a reasonable basis for our opinion.

/s/ Grant Thornton Audit Pty Ltd
GRANT THORNTON AUDIT PTY LTD

We served as the Company’s auditor from 2012 to 2022.
Sydney, Australia
October 14, 2022
F-5

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Consolidated statements of profit or loss and other comprehensive
income
For the year ended 30 June 2024

|  | Note |  |  | 2024 A$’000 |  |  | 2023 A$’000 |  |  | 2022 restated A$’000 |
Revenue from continuing operations |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Licensing revenue |  |  | 6 |  |  |  | 2,308 |  |  |  | — |  |  |  | — |
Other income |  |  | 8 |  |  |  | 173 |  |  |  | 1 |  |  |  | 25 |
Finance income |  |  |  |  |  |  | 12 |  |  |  | 22 |  |  |  | 2 |
Expenses |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and development expense |  |  | 9 |  |  |  | (17,380 | ) |  |  | (15,564 | ) |  |  | (20,169 | )
General and administrative expense |  |  | 9 |  |  |  | (13,563 | ) |  |  | (8,583 | ) |  |  | (5,113 | )
Gain/(loss) on remeasurement of other financial liabilities |  |  | 21 |  |  |  | 1,257 |  |  |  | — |  |  |  | — |
Gain/(loss) on remeasurement of promissory note |  |  |  |  |  |  | 25 |  |  |  | — |  |  |  | — |
Gain/(loss) on remeasurement of contingent consideration |  |  | 19 |  |  |  | 119 |  |  |  | 3,388 |  |  |  | — |
Commercialisation |  |  |  |  |  |  | — |  |  |  | — |  |  |  | (127 | )
Loss before income tax benefit |  |  |  |  |  |  | (27,049 | ) |  |  | (20,736 | ) |  |  | (25,382 | )
Income tax benefit |  |  | 10 |  |  |  | 271 |  |  |  | 271 |  |  |  | 368 |
Loss after income tax benefit |  |  |  |  |  |  | (26,778 | ) |  |  | (20,465 | ) |  |  | (25,014 | )
Other comprehensive loss |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Items that may be reclassified subsequently to profit or loss |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net exchange difference on translation of financial statements of foreign controlled entities, net of tax |  |  |  |  |  |  | (8 | ) |  |  | 110 |  |  |  | 35 |
Other comprehensive loss, net of tax |  |  |  |  |  |  | (8 | ) |  |  | 110 |  |  |  | 35 |
Total comprehensive loss |  |  |  |  |  |  | (26,786 | ) |  |  | (20,355 | ) |  |  | (24,979 | )

|  | Note |  |  | 2024 A$ Cents |  |  | 2023 A$ Cents |  |  | 2022 restated A$ Cents |
Earnings per share for loss attributable to the owners of Kazia Therapeutics Limited |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basic and diluted earnings per share |  |  | 33 |  |  |  | (10.16 | ) |  |  | (11.23 | ) |  |  | (18.88 | )

Refer to note 4 for detailed information on restatement of comparatives.
Refer to note 5 for detailed information on reclassification of comparatives.
The above consolidated statements of profit or loss or other comprehensive income should be read with the accompanying notes
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Table of Contents
Consolidated statements of financial position
As of 30 June 2024 and 2023

|  | Note |  |  | 2024 A$’000 |  |  | 2023 A$’000 |
Assets: |  |  |  |  |  |  |  |  |  |  |  |
Current assets: |  |  |  |  |  |  |  |  |  |  |  |
Cash and cash equivalents |  |  | 11 |  |  |  | 1,657 |  |  |  | 5,241 |
Trade and other receivables |  |  | 12 |  |  |  | 3,897 |  |  |  | 3,899 |
Other assets |  |  | 14 |  |  |  | 591 |  |  |  | 1,632 |
Total current assets |  |  |  |  |  |  | 6,145 |  |  |  | 10,772 |
Non-current assets: |  |  |  |  |  |  |  |  |  |  |  |
Other receivables |  |  | 13 |  |  |  | 40 |  |  |  | 43 |
Intangibles |  |  | 15 |  |  |  | 15,400 |  |  |  | 17,269 |
Total non-current assets |  |  |  |  |  |  | 15,440 |  |  |  | 17,312 |
Total assets |  |  |  |  |  |  | 21,585 |  |  |  | 28,084 |
Liabilities: |  |  |  |  |  |  |  |  |  |  |  |
Current liabilities |  |  |  |  |  |  |  |  |  |  |  |
Trade and other payables |  |  | 16 |  |  |  | 15,067 |  |  |  | 4,329 |
Other financial liabilities |  |  | 21 |  |  |  | 6,478 |  |  |  | — |
Borrowings |  |  | 17 |  |  |  | 634 |  |  |  | 1,796 |
Employee benefits |  |  | 18 |  |  |  | 365 |  |  |  | 690 |
Contingent consideration |  |  | 19 |  |  |  | 3,253 |  |  |  | 750 |
Total current liabilities |  |  |  |  |  |  | 25,797 |  |  |  | 7,565 |
Non-Current liabilities |  |  |  |  |  |  |  |  |  |  |  |
Deferred tax |  |  | 20 |  |  |  | 2,018 |  |  |  | 2,289 |
Employee benefits |  |  | 18 |  |  |  | 35 |  |  |  | 59 |
Contingent consideration |  |  | 19 |  |  |  | 3,752 |  |  |  | 6,121 |
Total non-current liabilities |  |  |  |  |  |  | 5,805 |  |  |  | 8,469 |
Total liabilities |  |  |  |  |  |  | 31,602 |  |  |  | 16,034 |
Equity: |  |  |  |  |  |  |  |  |  |  |  |
Contributed equity |  |  | 2 2 |  |  |  | 101,638 |  |  |  | 97,452 |
Reserves |  |  | 2 3 |  |  |  | 3,475 |  |  |  | 3,681 |
Accumulated losses |  |  |  |  |  |  | (115,130 | ) |  |  | (89,083 | )
Total equity |  |  |  |  |  |  | (10,017 | ) |  |  | 12,050 |
Total liabilities and shareholders’ (deficit) / equity |  |  |  |  |  |  | 21,585 |  |  |  | 28,084 |

Refer to note 4 for detailed information on restatement of comparatives.
Refer to note 5 for detailed information on reclassification of comparatives.
The above consolidated statements of financial position should be read with the accompanying notes
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Consolidated statements of changes in
equity
For
the
year
ended
30
June 2024

|  | Contributed equity A$’000 |  |  | Other Contributed equity A$’000 |  |  | Reserves A$’000 |  |  | Accumulated Losses A$’000 |  |  | Total equity A$’000 |
Balance at 1 July 2023 |  |  | 97,452 |  |  |  | — |  |  |  | 3,681 |  |  |  | (89,083 | ) |  |  | 12,050 |
Loss after income tax benefit |  |  | — |  |  |  | — |  |  |  | — |  |  |  | (26,778 | ) |  |  | (26,778 | )
Other comprehensive loss, net of tax |  |  | — |  |  |  | — |  |  |  | (8 | ) |  |  | — |  |  |  | (8 | )
Total comprehensive loss for the year |  |  | — |  |  |  | — |  |  |  | (8 | ) |  |  | (26,778 | ) |  |  | (26,786 | )
Transactions with owners in their capacity as owners |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issued (note 22) |  |  | 4,182 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 4,182 |
Share issue cost (note 22) |  |  | (376 | ) |  |  | — |  |  |  | — |  |  |  | — |  |  |  | (376 | )
Share based payment (note 3 2 ) |  |  | — |  |  |  | — |  |  |  | 533 |  |  |  | — |  |  |  | 533 |
Expired options |  |  | — |  |  |  | — |  |  |  | (731 | ) |  |  | 731 |  |  |  | — |
Shares issued upon conversion of convertible note |  |  | 380 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 380 |
Balance at 30 June 2024 |  |  | 101,638 |  |  |  | — |  |  |  | 3,475 |  |  |  | (115,130 | ) |  |  | (10,017 | )

|  | Contributed equity A$’000 |  |  | Other Contributed equity A$’000 |  |  | Reserves A$’000 |  |  | Accumulated Losses A$’000 |  |  | Total equity A$’000 |
Balance at 1 July 2022 (restated) |  |  | 84,480 |  |  |  | — |  |  |  | 2,412 |  |  |  | (68,617 | ) |  |  | 18,275 |
Loss after income tax benefit |  |  | — |  |  |  | — |  |  |  | — |  |  |  | (20,465 | ) |  |  | (20,465 | )
Other comprehensive income, net of tax |  |  | — |  |  |  | — |  |  |  | 110 |  |  |  | — |  |  |  | 110 |
Total comprehensive income (loss) |  |  | — |  |  |  | — |  |  |  | 110 |  |  |  | (20,465 | ) |  |  | (20,355 | )
Transactions with owners in their capacity as owners |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issued (note 22) |  |  | 13,373 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 13,373 |
Share issue cost (note 22) |  |  | (401 | ) |  |  | — |  |  |  | — |  |  |  | — |  |  |  | (401 | )
Share based payment (note 3 2 ) |  |  | — |  |  |  | — |  |  |  | 1,159 |  |  |  | — |  |  |  | 1,159 |
Balance at 30 June 2023 |  |  | 97,452 |  |  |  | — |  |  |  | 3,681 |  |  |  | (89,083 | ) |  |  | 12,050 |

|  | Contributed equity A$’000 |  |  | Other Contributed equity A$’000 |  |  | Reserves A$’000 |  |  | Accumulated Losses A$’000 |  |  | Total equity A$’000 |
Balance at 1 July 2021 (restated) |  |  | 80,290 |  |  |  | 464 |  |  |  | 1,301 |  |  |  | (44,202 | ) |  |  | 37,853 |
Loss after income tax benefit (restated) |  |  | — |  |  |  | — |  |  |  | — |  |  |  | (25,014 | ) |  |  | (25,014 | )
Other comprehensive income, net of tax |  |  | — |  |  |  | — |  |  |  | 35 |  |  |  | — |  |  |  | 35 |
Total comprehensive loss (restated) |  |  | — |  |  |  | — |  |  |  | 35 |  |  |  | (25,014 | ) |  |  | (24,979 | )
Transactions with owners in their capacity as owners |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issued (note 22) |  |  | 4,202 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 4,202 |
Share issue cost (note 22) |  |  | (493 | ) |  |  | — |  |  |  | — |  |  |  | — |  |  |  | (493 | )
Immaterial reclassification |  |  | — |  |  |  | — |  |  |  | (434 | ) |  |  | 434 |  |  |  | — |
Share based payment (note 3 2 ) |  |  | — |  |  |  | — |  |  |  | 1,674 |  |  |  | — |  |  |  | 1,674 |
Issue of shares on exercise of options |  |  | 17 |  |  |  | — |  |  |  | (6 | ) |  |  | 6 |  |  |  | 17 |
Conversion of convertible note |  |  | 464 |  |  |  | (464 | ) |  |  | — |  |  |  | — |  |  |  | — |
Expired options |  |  | — |  |  |  | — |  |  |  | (159 | ) |  |  | 159 |  |  |  | — |
Balance at 30 June 2022 (restated) |  |  | 84,480 |  |  |  | — |  |  |  | 2,412 |  |  |  | (68,617 | ) |  |  | 18,275 |

Refer to note 4 for detailed information on restatement of comparatives.
The above consolidated statements of changes in equity should be read with the accompanying notes
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Consolidated statements of cash flows
For the year ended 30 June 2024

|  | Note |  |  | 2024 A$‘000 |  |  | 2023 A$‘000 |  |  | 2022 restated A$‘000 |
CASH FLOWS FROM OPERATING ACTIVITIES: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss after income tax expense for the year |  |  |  |  |  | $ | (26,778 | ) |  | $ | (20,465 | ) |  | $ | (25,014 | )
Adjustments for: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amortisation |  |  | 9 |  |  |  | 1,869 |  |  |  | 1,869 |  |  |  | 1,869 |
Issuance of liability classified warrants for services |  |  | 21 |  |  |  | 5,961 |  |  |  | — |  |  |  | — |
Share-based payments |  |  | 3 2 |  |  |  | 533 |  |  |  | 1,159 |  |  |  | 1,675 |
Foreign currency (gain) / loss |  |  | 9 |  |  |  | (20 | ) |  |  | 46 |  |  |  | (2,154 | )
Loss/(gain) on remeasurement of contingent consideration |  |  | 19 |  |  |  | 134 |  |  |  | (2,097 | ) |  |  | — |
Gain on remeasurement of promissory note |  |  |  |  |  |  | (25 | ) |  |  | — |  |  |  | — |
Gain on remeasurement of financial assets |  |  | 21 |  |  |  | (1,257 | ) |  |  | — |  |  |  | — |
|  |  |  |  |  |  | (19,583 | ) |  |  | (19,488 | ) |  |  | (23,624 | )
Change in operating assets and liabilities: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Increase/(decrease) in trade and other receivables |  |  |  |  |  |  | 5 |  |  |  | 3,450 |  |  |  | (7 | )
Increase/(decrease) in other assets |  |  |  |  |  |  | 1,041 |  |  |  | 365 |  |  |  | (277 | )
Increase/(decrease) in trade and other payables |  |  |  |  |  |  | 10,738 |  |  |  | 569 |  |  |  | (528 | )
(Decrease)/increase in other provisions |  |  |  |  |  |  | (349 | ) |  |  | 264 |  |  |  | 201 |
Decrease in deferred tax liability |  |  |  |  |  |  | (271 | ) |  |  | (271 | ) |  |  | (368 | )
(Decrease)/increase in borrowings |  |  |  |  |  |  | (1,162 | ) |  |  | (45 | ) |  |  | 1,841 |
Net cash used in operating activities |  |  |  |  |  |  | (9,581 | ) |  |  | (15,156 | ) |  |  | (22,762 | )
CASH FLOWS FROM INVESTING ACTIVITIES: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payment of milestone related to contingent consideration |  |  |  |  |  |  | — |  |  |  | — |  |  |  | (2,365 | )
Net cash used in investing activities |  |  |  |  |  |  | — |  |  |  | — |  |  |  | (2,365 | )
CASH FLOWS FROM FINANCING ACTIVITIES: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from issuance of shares, net of transaction costs |  |  | 22 |  |  |  | 2,914 |  |  |  | 12,972 |  |  |  | 3,726 |
Proceeds from issuance of equity and pre-funded warrants |  |  | 21 |  |  |  | 2,666 |  |  |  | — |  |  |  | — |
Proceeds from promissory note |  |  | 17 |  |  |  | 776 |  |  |  | — |  |  |  | — |
Repayment of promissory note |  |  | 17 |  |  |  | (371 | ) |  |  | — |  |  |  | — |
Net cash provided by financing activities |  |  |  |  |  |  | 5,985 |  |  |  | 12,972 |  |  |  | 3,726 |
Net (decrease)/increase in cash and cash equivalents |  |  |  |  |  |  | (3,596 | ) |  |  | (2,184 | ) |  |  | (21,401 | )
Cash and cash equivalents at the beginning of the financial year |  |  |  |  |  |  | 5,241 |  |  |  | 7,361 |  |  |  | 27,587 |
Effects of exchange rate changes on cash |  |  |  |  |  |  | 12 |  |  |  | 64 |  |  |  | 1,175 |
Cash and cash equivalents at the end of the financial year |  |  |  |  |  | $ | 1,657 |  |  | $ | 5,241 |  |  | $ | 7,361 |
NON-CASH INVESTING AND FINANCING ACTIVITIES |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion of convertible promissory note |  |  | 22 |  |  |  | 380 |  |  |  | — |  |  |  | — |
Exercise of pre-funded warrants |  |  | 21 |  |  |  | 864 |  |  |  | — |  |  |  | — |

Refer to note 4 for detailed information on restatement of comparatives.
Refer to note 5 for detailed information on reclassification of comparatives.
The above consolidated statements of changes in equity should be read with the accompanying notes
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Notes to the consolidated financial statements
30 June 2024
Note 1. General information
The consolidated financial statements cover Kazia Therapeutics Limited (the “Consolidated Entity”, the “Company” or “Kazia”) as a consolidated entity which consists of Kazia Therapeutics Limited and its subsidiaries. The consolidated financial statements are presented in Australian dollars, which is Kazia Therapeutics Limited’s functional and reporting currency.
Kazia Therapeutics Limited is a listed public company limited by shares, incorporated and domiciled in Australia. Its registered office and principal place of business is:
Three International Towers
Level 24, 300 Barangaroo Avenue
Sydney NSW 2000
The consolidated financial statements were authorized for issue, in accordance with a resolution of Directors, on
15 November
2024. The Directors have the power to amend and reissue the consolidated financial statements.
Note 2. Material accounting policies
The material accounting policies adopted in the preparation of the consolidated financial statements are set out below. These policies have been consistently applied to all the years presented, unless otherwise stated.
New or amended Accounting Standards and Interpretations adopted
The Consolidated Entity has adopted all of the new, revised or amending Accounting Standards and Interpretations issued by the International Accounting Standards Board (‘IASB’) that are mandatory for the current reporting period.
The adoption of these standards has not had any material impact on the disclosures or amounts reported in these consolidated financial statements.
New Accounting Standards and Interpretations not yet mandatory or early adopted
In April 2024, IFRS 18, “Presentation and Disclosure in Financial Statements” was issued to achieve comparability of the financial performance of similar entities. The standard, which replaces IAS 1 “Presentation of Financial Statements”, impacts the presentation of primary financial statements and notes, including the statement of earnings where companies will be required to present separate categories of income and expense for operating, investing, and financing activities with prescribed subtotals for each new category. The standard will also require management-defined performance measure to be explained and included in a separate note within the consolidated financial statements. The standard is effective for annual reporting periods beginning on or after January 1, 2027, including interim financial statements, and require retroactive application. The Consolidated Entity is currently assessing the impact of the new standard.
The Consolidated Entity is currently analyzing the potential impact of the amendments to IFRS 9 “Financial Instruments”, IFRS 7 “Financial Instruments: Disclosures”, and small changes to various standards or interpretations as part of the annual improvements to IFRS project. The amendments are effective for reporting periods beginning on or after 1 January 2026.
There were no other new accounting standards and interpretations not yet adopted by the Consolidated Entity for the 30 June 2024 reporting period that are expected to materially impact the Consolidated Entity.
Going concern
The Consolidated Entity incurred a loss after income tax of A$26.8 million was in a net current liability position of A$19.7 million and had net cash outflows from operating activities of A$9.6 million as at and for the year ended 30 June 2024.
As at 30 June 2024 the Consolidated Entity had cash and cash equivalents
of A$1.7 million
.
The consolidated financial statements have been prepared on a going concern basis, which contemplates continuity of normal activities and realization of assets and settlement of liabilities in the normal course of business. As is often the case with drug development companies, the Company has not generated significant revenues nor does the Company anticipate generating significant revenues in the near future. The ability of the Consolidated Entity to continue its development activities as a going concern is dependent upon it deriving sufficient cash from investors, from licensing and partnering activities, and from other sources of revenue such as grant funding.
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Notes to the financial statements
30 June 2024
Note 2. Material accounting policies (continued)
The directors have considered the cash flow forecasts and the funding requirements of the business and continue to explore grant funding, licensing opportunities and equity investment opportunities in the Company.
The
at-the-market’
equity program (“ATM”) allows the Company to raise capital dynamically in the market, with no discount, no warrant coverage, and modest banking fees, allowing it to fund operations with minimal dilution to existing shareholders. An ATM with Oppenheimer & Co. Inc. (Oppenheimer) as sales agent was established in May 2022. Under the ATM, Kazia may offer and sell via Oppenheimer the remaining capacity of
US$22.6 million
of its ordinary shares, in the form of American Depository Shares (ADSs), with each ADS representing 100 ordinary shares. Kazia entered into an Equity Distribution Agreement, dated as of 22 April 2022 (the
“
Sales Agreement
”),
with Oppenheimer, acting as sales agent for an initial capacity of US$35 million. On 4 September 2024, the Equity Distribution Agreement was amended to increase the aggregate offering price to US$50 million. During the year ended 30 June 2024 US$1,656,016 was drawn down from the ATM facility compared to US$4,203,221 for the year ended 30 June 2023.
From July through September 2024, the Consolidated Entity raised total proceeds of US$3,609,757 using the ATM facility and continues to seek additional funding sources both in Australia and overseas. For the same period
,
the Consolidated Entity also raised total proceeds of A$816,373 through its equity line of credit facility.
Accordingly
,
the directors have prepared the
consolidated
financial statements on a going concern basis. There is substantial doubt on whether the Consolidated Entity will continue as a going concern and therefore whether it will realize its assets and extinguish its liabilities in the normal course of business and at the amounts stated in these
consolidated
financial statements.
Basis of preparation
These general purpose consolidated financial statements have been prepared in accordance with Australian Accounting Standards and Interpretations issued by the Australian Accounting Standards Board (‘AASB’) and the Corporations Act, as appropriate for
for-profit
oriented entities. These consolidated financial statements also comply with International Financial Reporting Standards as issued by the International Accounting Standards Board (‘IASB’).
Critical accounting estimates
The preparation of the consolidated financial statements requires the use of certain critical accounting estimates. It also requires management to exercise its judgement in the process of applying the Consolidated Entity’s accounting policies. The areas involving a higher degree of judgement or complexity, or areas where assumptions and estimates are significant to the consolidated financial statements, are disclosed in note 3.
Parent entity information
In accordance with the Corporations Act, these consolidated financial statements present the results of the Consolidated Entity only. Supplementary information about the parent entity is disclosed in note 29.
Principles of consolidation
The consolidated financial statements incorporate the assets and liabilities of all subsidiaries of Kazia Therapeutics Limited. Kazia Therapeutics Limited and its subsidiaries together are referred to in these consolidated financial statements as the ‘Consolidated Entity’.
Subsidiaries are all those entities over which the Consolidated Entity has control. The Consolidated Entity controls an entity when the Consolidated Entity is exposed to, or has rights to, variable returns from its involvement with the entity and has the ability to affect those returns through its power to direct the activities of the entity. Subsidiaries are fully consolidated from the date on which control is transferred to the Consolidated Entity. They are
de-consolidated
from the date that control ceases.
Intercompany transactions, balances and unrealized gains on transactions between entities in the Consolidated Entity are eliminated. Unrealized losses are also eliminated unless the transaction provides evidence of the impairment of the asset transferred. Accounting policies of subsidiaries have been changed where necessary to ensure consistency with the policies adopted by the Consolidated Entity.
The acquisition of subsidiaries is accounted for using the acquisition method of accounting. A change in ownership interest, without the loss of control, is accounted for as an equity transaction, where the difference is between the consideration transferred and the book value.
Where the Consolidated Entity loses control over a subsidiary, it derecognize the assets including goodwill, liabilities and
non-controlling
interest in the subsidiary together with any cumulative translation differences recognized in equity. The Consolidated Entity recognizes the fair value of the consideration received and the fair value of any investment retained together with any gain or loss in profit or loss.
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Notes to the financial statements
30 June 2024
Note 2. Material accounting policies (continued)
Operating segments
Operating segments are presented using the ‘management approach’ where the information presented is on the same basis as the internal reports provided to the Chief Operating Decision Makers (‘CODM’). The CODM is responsible for the allocation of resources to operating segments and assessing their performance. The CODM is considered to be the Board of Directors.
Foreign currency translation
The consolidated financial statements are presented in Australian dollars.
Foreign currency transactions
Foreign currency transactions are translated into Australian dollars using the exchange rates prevailing at the dates of the transactions. Foreign exchange gains and losses resulting from the settlement of such transactions and from the translation at reporting date exchange rates of monetary assets and liabilities denominated in foreign currencies are recognized in profit or loss.
Foreign operations
The assets and liabilities of foreign operations are translated into Australian dollars using the exchange rates at the reporting date. The revenues and expenses of foreign operations are translated into Australian dollars using the average exchange rates, which approximate the rate at the date of the transaction, for the period. All resulting foreign exchange differences are recognized in other comprehensive income through the foreign currency reserve in equity.
The foreign currency reserve is recognized in profit or loss when the foreign operation is disposed of.
Exchange differences arising on a monetary item that forms part of a reporting entity’s net investment in a foreign operation shall be recognized initially in other comprehensive income and reclassified from equity to profit or loss on disposal of the net investment.
Financial Instruments
Subsequent measurement of financial assets
For the purpose of subsequent measurement, financial assets are classified into the following categories upon initial recognition:

• |  | financial assets at amortized cost

• |  | financial assets at fair value through profit or loss (FVPL)

Classifications are determined by both:

• |  | the entity’s business model for managing the financial asset

• |  | the contractual cash flow characteristics of the financial assets

All income and expenses relating to financial assets that are recognized in profit or loss are presented within finance costs, finance income or other financial items, except for impairment of trade receivables which is presented within other expenses.
Financial assets at amortised cost
Financial assets are measured at amortised cost if the assets meet the following conditions (and are not designated as FVPL):

• |  | they are held within a business model whose objective is to hold the financial assets and collect its contractual cash flows; and

• |  | the contractual terms of the financial assets give rise to cash flows that are solely payments of principal and interest on the principal amount outstanding.

After initial recognition, these are measured at amortised cost using the effective interest method. Discounting is omitted where the effect of discounting is immaterial. The Consolidated Entity’s cash and cash equivalents, trade and most other receivables fall into this category of financial instruments.
Classification and measurement of financial liabilities
The Consolidated Entity’s financial liabilities comprise trade and other payables. Financial liabilities, borrowings and contingent consideration for business combination and licensing agreement acquisitions are initially measured at fair value, and, where applicable, adjusted for transaction costs unless the Consolidated Entity designated a financial liability at fair value through profit or loss. Subsequently, financial liabilities are measured at amortised cost using the effective interest method, except for contingent consideration in a business combination and liability classified warrants, which are measured at fair value.
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Notes to the financial statements
30 June 2024
Note 2. Material accounting policies (continued)
All interest-related charges and, if applicable, changes in an instrument’s fair value that are reported in profit or loss are included within finance costs or finance income.
Revenue from contracts with customers
Revenue is measured at the fair value of the consideration received or receivable. Revenue is recognized using a five step approach in accordance with IFRS 15, “Revenue from Contracts with Customers” to depict the transfer of promised services to customers in an amount that reflects the consideration to which the Group expects to be entitled in exchange for those services. Distinct promises within the contract are identified as performance obligations. The transaction price of the contract is measured based on the amount of consideration the Consolidated Entity expects to be entitled to from the customer in exchange for services. Factors such as requirements around variable consideration, significant financing components, noncash consideration, or amounts payable to customers also determine the transaction price. The transaction price is then allocated to separate performance obligations in the contract based on relative standalone selling prices. Revenue is recognized when, or as, performance obligations are satisfied, which is when control of the promised service is transferred to the customer. Amounts received prior to satisfying the revenue recognition criteria are recorded as deferred revenue. Amounts expected to be recognized as revenue within the 12 months following the balance sheet date are classified within current liabilities. Amounts not expected to be recognized as revenue within the 12 months following the balance sheet date are classified within
non-current
liabilities.
The Consolidated Entity recognizes contract liabilities for consideration received in respect of unsatisfied performance obligations and reports these amounts as other liabilities in its consolidated statement of financial position. Similarly, if the Consolidated Entity satisfies a performance obligation before it receives the consideration, the Consolidated Entity recognizes either a contract asset or a receivable in its statement of financial position, depending on whether something other than the passage of time is required before the consideration is due.
Licensing revenues, including milestone revenue
Revenue from licensees of the Consolidated Entity’s intellectual property reflects the transfer of a right to use the intellectual property as it exists at the point in time in which the license is transferred to the customer.
Licensing agreements are examined to determine whether they contain additional performance obligations, over and above the right to use the intellectual property. To the extent that additional performance obligations exist, the transaction price the Consolidated Entity expects to receive for the contract is allocated to the separate performance obligations.
The receipt of milestone payments is often contingent on meeting certain clinical, regulatory or commercial targets, and is therefore considered variable consideration. The transaction price of the contingent milestone is estimated using the most likely amount method. Within the transaction price, the price associated with a contingent milestone is included only to the extent that it is highly probable that a significant reversal in the amount of cumulative revenue recognized will not occur. Milestone payments that are not within the control of the Group, such as regulatory approvals, are not considered highly probable of being achieved until those approvals are achieved.
Finance income
Interest revenue is recognized as interest accrues using the effective interest method. This is a method of calculating the amortised cost of a financial asset and allocating the interest income over the relevant period using the effective interest rate, which is the rate that exactly discounts estimated future cash receipts through the expected life of the financial asset to the net carrying amount of the financial asset.
Grant income
Grants from governments are recognized at their fair value when there is a reasonable assurance that the grant will be received and the Company will comply with all attached conditions. Government grants relating to operating costs are recognized in the Statements of Comprehensive Income as other income. A New South Wales Export Development Grant was received in the year ended 30 June 2022.
Other income
Other income is recognized when it is received or when the right to receive payment is established.
Income tax
Income tax expense or benefit for the period is the tax payable on that period’s taxable income based on the applicable income tax rate for each jurisdiction, adjusted by changes in deferred tax assets and liabilities attributable to temporary differences, unused tax losses and the adjustment recognized for prior periods, where applicable.
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Notes to the financial statements
30 June 2024
Note 2. Material accounting policies (continued)
Deferred tax assets and liabilities are recognized for temporary differences at the tax rates expected to apply when the assets are recovered or liabilities are settled, based on those tax rates that are enacted or substantively enacted, except for:

• |  | When the deferred income tax asset or liability arises from the initial recognition of goodwill or an asset or liability in a transaction that is not a business combination and that, at the time of the transaction, affects neither the accounting nor taxable profits; or

• |  | When the taxable temporary difference is associated with interests in subsidiaries, associates or joint ventures, and the timing of the reversal can be controlled and it is probable that the temporary difference will not reverse in the foreseeable future.

Deferred tax assets are recognized for deductible temporary differences and unused tax losses only if it is probable that future taxable amounts will be available to utilize those temporary differences and losses.
The carrying amount of recognized and unrecognized deferred tax assets are reviewed each reporting date. Deferred tax assets recognized are reduced to the extent that it is no longer probable that future taxable profits will be available for the carrying amount to be recovered. Previously unrecognized deferred tax assets are recognized to the extent that it is probable that there are future taxable profits available to recover the asset.
Deferred tax assets and liabilities are offset only where there is a legally enforceable right to offset current tax assets against current tax liabilities and deferred tax assets against deferred tax liabilities; and they relate to the same taxable authority on either the same taxable entity or different taxable entities which intend to settle simultaneously.
Kazia Therapeutics Limited and its wholly-owned Australian controlled entities have formed an income tax consolidated group under the tax consolidation regime. Kazia Therapeutics Limited as the parent entity discloses all of the deferred tax assets of the tax consolidated group in relation to tax losses carried forward (after elimination of inter-group transactions). The tax consolidated group has applied the ‘separate taxpayer in the group’ allocation approach in determining the appropriate amount of taxes to allocate to members of the tax consolidated group.
As the tax consolidation group continues to generate tax losses there has been no reason for the Company to enter a tax funding agreement with members of the tax consolidation group.
Uncertain tax positions
IFRIC 23 clarified the application of the recognition and measurement criteria of IAS 12, “Income Taxes,” where there is uncertainty over income tax treatments and requires an assessment of each uncertain tax position as to whether it is probable that a taxation authority will accept the position. Where it is not probable, the effect of the uncertainty is reflected in determining the relevant taxable profit or loss, tax bases, unused tax losses and unused tax credits or tax rates. The amount is determined as either the single most likely amount or the sum of the probability weighted amounts in a range of possible outcomes, whichever better predicts the resolution of the uncertainty. Management believes that historical tax losses are not expected to be available for offset against the deferred tax liability at 30 June 2024 and 2023.
Current and
non-current
classification
Assets and liabilities are presented in the statement of financial position based on current and
non-current
classification.
An asset is current when: it is expected to be realized or intended to be sold or consumed in normal operating cycle; it is held primarily for the purpose of trading; it is expected to be realized within 12 months after the reporting period; or the asset is cash or cash equivalent unless restricted from being exchanged or used to settle a liability for at least 12 months after the reporting period. All other assets are classified as
non-current.
A liability is current when: it is expected to be settled in normal operating cycle; it is held primarily for the purpose of trading; it is due to be settled within 12 months after the reporting period; or there is no unconditional right to defer the settlement of the liability for at least 12 months after the reporting period. All other liabilities are classified as
non-current.
Deferred tax assets and liabilities are always classified as
non-current.
Cash and cash equivalents
Cash and cash equivalents includes cash on hand, deposits held at call with financial institutions, other short-term, highly liquid investments with original maturities of three months or less that are readily convertible to known amounts of cash and which are subject to an insignificant risk of changes in value.
Research and development
Expenditure during the research phase of a project is recognized as an expense when incurred. Development costs are capitalized only when technical feasibility studies identify that the project will deliver future economic benefits and these benefits can be measured reliably.
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Notes to the financial statements
30 June 2024
Note 2. Material accounting policies (continued)
Intangible assets
Separately acquired intangible assets are shown at historical cost. The cost of intangible assets acquired as part of a business combination is their fair value at the acquisition date. They have a finite useful life and are subsequently carried at cost less accumulated amortization and impairment losses. The method and useful lives of finite life intangible assets are reviewed annually. Changes in the expected pattern of consumption or useful life are accounted for prospectively by changing the amortization method or period. Amortization expense is included in research and development expenditure.
Licensing agreement for paxalisib
The paxalisib licensing agreement asset was acquired as part of a business combination and is being amortised on a straight-line basis over the period of its expected benefit, being the remaining life of the patent which was 15 years from the date of acquisition.
Licensing agreement for EVT801
The EVT801 licensing agreement asset was acquired via an asset acquisition and is being amortised on a straight-line basis over the period of its expected benefit, being the remaining life of the patent which was 12.5 years from the date of acquisition.
Impairment of
non-financial
assets
Non-financial
assets with finite useful lives are reviewed for impairment whenever events or changes in circumstances indicate that the carrying amount may not be recoverable. An impairment loss is recognized for the amount by which the asset’s carrying amount exceeds its recoverable amount.
Recoverable amount is the higher of an asset’s fair value less costs of disposal and
value-in-use.
The
value-in-use
is the present value of the estimated future cash flows relating to the asset using a
pre-tax
discount rate specific to the asset or cash-generating unit to which the asset belongs. Assets that do not have independent cash flows are grouped together to form a cash-generating unit.
Provisions
Provisions are recognized when the Consolidated Entity has a present (legal or constructive) obligation as a result of a past event, it is probable the Consolidated Entity will be required to settle the obligation, and a reliable estimate can be made of the amount of the obligation. The amount recognized as a provision is the best estimate of the consideration required to settle the present obligation at the reporting date, taking into account the risks and uncertainties surrounding the obligation. If the time value of money is material, provisions are discounted using a current
pre-tax
rate specific to the liability. The increase in the provision resulting from the passage of time is recognized as a finance cost.
Employee benefits
Short-term employee benefits
Liabilities for wages and salaries, including
non-monetary
benefits, annual leave and long service leave expected to be settled within 12 months of the reporting date are measured at the amounts expected to be paid when the liabilities are settled.
Other long-term employee benefits
The liability for annual leave and long service leave not expected to be settled within 12 months of the reporting date is measured as the present value of expected future payments to be made in respect of services provided by employees up to the reporting date using the projected unit credit method. Consideration is given to expected future wage and salary levels, experience of employee departures and periods of service. Expected future payments are discounted using market yields at the reporting date on high quality corporate bonds with terms to maturity and currency that match, as closely as possible, the estimated future cash outflows.
Share-based payments
Equity-settled share-based compensation benefits are provided to employees under the terms of the Employee Share Option Plan (‘ESOP’) and consultants as compensation for services performed.
Equity-settled transactions are awards of shares, or options over shares that are provided to employees in exchange for the rendering of services.
The value of the instruments is measured by reference to the fair value of the underlying instruments on grant date, as required by IFRS2, “Share-Based Payments.” Fair value is estimated using an appropriate option pricing model that takes into account the exercise price, the term of the option, the impact of dilution, the share price at grant date and expected price volatility of the underlying share, the expected dividend yield and the risk free interest rate for the term of the option, together with
non-vesting
conditions that do not determine whether the Consolidated Entity receives the services that entitle the employees to receive payment. No account is taken of any other vesting conditions.
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Notes to the financial statements
30 June 2024
Note 2. Material accounting policies (continued)
The cost of equity-settled transactions are recognized as an expense with a corresponding increase in equity over the vesting period. The cumulative charge to profit or loss is calculated based on the grant date fair value of the award, the best estimate of the number of awards that are likely to vest and the expired portion of the vesting period. The amount recognized in profit or loss for the period is the cumulative amount calculated at each reporting date less amounts already recognized in previous periods.
The cumulative charge to profit or loss until settlement of the options is calculated as follows:

• |  | during the options vesting period, the liability at each reporting date is the fair value of the award at that date multiplied by the expired portion of the vesting period.

• |  | from the end of the option vesting period until settlement of the award, the liability is the full fair value of the option at the reporting date.

Market conditions are taken into consideration in determining fair value. Therefore, any awards subject to market conditions are considered to vest irrespective of whether or not that market condition has been met, provided all other conditions are satisfied.
If equity-settled awards are modified, as a minimum an expense is recognized as if the modification has not been made. An additional expense is recognized, over the remaining vesting period, for any modification that increases the total fair value of the share-based compensation benefit as at the date of modification.
If the
non-vesting
condition is within the control of the Consolidated Entity or employee, the failure to satisfy the condition is treated as a cancellation. If the condition is not within the control of the Consolidated Entity or employee and is not satisfied during the vesting period, any remaining expense for the award is recognized over the remaining vesting period, unless the award is forfeited.
If equity-settled awards are cancelled, it is treated as if it has vested on the date of cancellation, and any remaining expense is recognized immediately. If a new replacement award is substituted for the cancelled award, the cancelled and new award is treated as if they were a modification.
Finance costs
Finance costs attributable to qualifying assets are capitalized as part of the asset. All other finance costs are expensed in the period in which they are incurred, including interest on short-term and long-term borrowings.
Fair value measurement
When an asset or liability, financial or
non-financial,
is measured at fair value for recognition or disclosure purposes, the fair value is based on the price that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date; and assumes that the transaction will take place either: in the principal market; or in the absence of a principal market, in the most advantageous market.
Fair value is measured using the assumptions that market participants would use when pricing the asset or liability, assuming they act in their economic best interest. For
non-financial
assets, the fair value measurement is based on its highest and best use. Valuation techniques that are appropriate in the circumstances and for which sufficient data are available to measure fair value, are used, maximizing the use of relevant observable inputs and minimizing the use of unobservable inputs.
Assets and liabilities measured at fair value are classified, into three levels, using a fair value hierarchy that reflects the significance of the inputs used in making the measurements. Classifications are reviewed each reporting date and transfers between levels are determined based on a reassessment of the lowest level input that is significant to the fair value measurement.
For recurring and
non-recurring
fair value measurements, external valuers may be used when internal expertise is either not available or when the valuation is deemed to be significant. External valuers are selected based on market knowledge and reputation. Where there is a significant change in fair value of an asset or liability from one period to another, an analysis is undertaken, which includes a verification of the major inputs applied in the latest valuation and a comparison, where applicable, with external sources of data.
Issued capital
Ordinary shares are classified as equity.
Incremental costs directly attributable to the issue of new shares or options, including share-based payments relating to the issue of shares, are shown in equity as a deduction, from the proceeds.
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Notes to the financial statements
30 June 2024
Note 2. Material accounting policies (continued)
Earnings per share
Basic earnings per share
Basic earnings per share is calculated by dividing the profit attributable to the owners of Kazia Therapeutics Limited, excluding any costs of servicing equity other than ordinary shares, by the weighted average number of ordinary shares outstanding during the financial year, adjusted for bonus elements in ordinary shares issued during the financial year.
Diluted earnings per share
Diluted earnings per share adjusts the figures used in the determination of basic earnings per share to take into account the after income tax effect of interest and other financing costs associated with dilutive potential ordinary shares and the weighted average number of shares assumed to have been issued for no consideration in relation to dilutive potential ordinary shares.
Goods and Services Tax (‘GST’) and other similar taxes
Revenues, expenses and assets are recognized net of the amount of associated GST, unless the GST incurred is not recoverable from the tax authority. In this case it is recognized as part of the cost of the acquisition of the asset or as part of the expense.
Receivables and payables are stated inclusive of the amount of GST receivable or payable. The net amount of GST recoverable from, or payable to, the tax authority is included in other receivables or other payables in the statement of financial position.
Cash flows are presented on a gross basis. The GST components of cash flows arising from investing or financing activities which are recoverable from, or payable to the tax authority, are presented as operating cash flows.
Commitments and contingencies are disclosed net of the amount of GST recoverable from, or payable to, the tax authority.
Note 3. Critical accounting judgements, estimates and assumptions
The preparation of the consolidated financial statements requires management to make judgements, estimates and assumptions that affect the reported amounts in the consolidated financial statements. Management continually evaluates its judgements and estimates in relation to assets, liabilities, contingent liabilities, revenue and expenses. Management bases its judgements, estimates and assumptions on historical experience and on other various factors, including expectations of future events, management believes to be reasonable under the circumstances. The resulting accounting judgements and estimates will seldom equal the related actual results. The judgements, estimates and assumptions that have a significant risk of causing a material adjustment to the carrying amounts of assets and liabilities (refer to the respective notes) within the next financial year are discussed as follows:
Research and development expenses
The Directors do not consider the development programs to be sufficiently advanced to reliably determine the economic benefits and technical feasibility to justify capitalization of development costs. These costs have been recognized as an expense when incurred.
Research and development expenses relate primarily to the cost of conducting human clinical and
pre-clinical
trials. Clinical development costs are a significant component of research and development expenses. Estimates have been used in determining the expense liability under certain clinical trial contracts where services have been performed but not yet invoiced. Generally the costs, and therefore estimates, associated with clinical trial contracts are based on the number of patients, drug administration cycles, the type of treatment and the outcome being measured. The length of time before actual amounts can be determined will vary depending on length of the patient cycles and the timing of the invoices by the clinical trial partners.
Clinical trial expenses
The timing of payment for work conducted under clinical trials often bears little relation to the timing of the work effort. Detailed estimates are made to determine the amount of work effort expended during a reporting period in order to determine the appropriate expense to be recognized, with the resulting prepayments or
un-invoiced
amounts being recognized as a prepayment or an accrual respectively.
Share-based payment transactions
The Consolidated Entity measures the cost of equity-settled transactions with employees by reference to the fair value of the equity instruments at the date at which they are granted. The fair value is estimated using an appropriate option pricing model taking into account the terms and conditions upon which the instruments were granted. The accounting estimates and assumptions relating to equity-settled share-based payments would have no impact on the carrying amounts of assets and liabilities within the next annual reporting period but may impact profit or loss and equity.
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Notes to the financial statements
30 June 2024
Note 3. Critical accounting judgements, estimates and assumptions (continued)
Acquisition of intangible assets
During the 2017 financial year, the Consolidated Entity acquired the rights to develop and commercialize paxalisib, as part of a business combination from Genentech. Significant judgement was required in determining that the transaction was a business combination and in relation to the identification and valuation of assets and liabilities acquired. The Consolidated Entity has applied judgement in determining the accounting treatment for the acquisition of the License agreement for EVT801. The License agreement has been determined to be a standalone transaction, independent from any other agreements which have been or may be entered into with Evotec (France) SAS. Management has also made the decision to account for the cost of the asset conferred by the License agreement on the basis of the milestones that are probable of being payable, that is, those for which there is judged to be a probability of greater than 50% that the milestone will be triggered.
Contingent consideration
Contingent consideration relates to the intangible assets acquired, and the fair value of contingent consideration is dependent on the key assumptions used in accounting for the acquisition of those intangible assets. These assumptions include the probability of milestones occurring, and can also include the anticipated timing of settlement and discount rates used.
In the case where contingent consideration is recognized on the basis that the liability is probable of occurring, judgement is used in determining which milestones are considered probable of being triggered and the timing thereof.
Intangible assets available for use
The Consolidated Entity has exercised judgement in determining that its intangible assets, being license agreements, have a finite life and are available for use once acquired. As the business model is to acquire such assets and then develop them to generate returns from future license transactions or other means, management have determined that the assets are available for use from the time that they are acquired. In each case the prima facie useful life is the remaining life of the patent over the asset, unless other factors over-ride this assessment.
Impairment of licensing agreements and other indefinite life intangible assets
The Consolidated Entity assesses impairment of licensing agreements at each reporting date by evaluating conditions specific to the Consolidated Entity and to the particular asset that may lead to impairment. Judgement is used to determine whether any indicators of impairment exist, and reference is made to the considerations included in IAS 36, Impairment of Assets, in this assessment. If an impairment trigger is found to exist, the recoverable amount of the asset is determined.
Note 4. Restatement of comparatives
During the year ended 30 June 2023, management determined the calculation of the
EVT-801
intangible asset and the related contingent consideration to contain certain errors,
specifically
, the calculation failed to appropriately discount future cash flows associated with the asset. The contractual payments in relation to the milestones gave rise to a financial liability at acquisition. The cost of the intangible asset should comprise the initial payment plus an amount reflecting the fair value of the other contingent payments determined using a probability-weighted estimation. These values should be discounted to reflect the time value of money at the time of acquisition in April 2021. In correcting this error, the Company utilized an Incremental Borrowing Rate of 6% to discount the future cash flows. The Incremental Borrowing Rate reflects the assumed credit rating of the Company.
The error resulted in a material overstatement of the
EVT-801
intangible asset and a corresponding overstatement of the liability at acquisition. The impact of this error is noted below with the restated balances disclosed in notes 15 and 19.

|  | 30 June 2022 Reported |  |  | Increase/ (decrease) |  |  | 30 June 2022 Restated |
|  | A$’000 |  |  | A$’000 |  |  | A$’000 |
Consolidated statement of financial position |  |  |  |  |  |  |  |  |  |  |  |
Intangibles - licensing agreement |  |  | 27,266 |  |  |  | (1,045 | ) |  |  | 26,221 |
Less Accumulated amortisation |  |  | (7,216 | ) |  |  | 134 |  |  |  | (7,082 | )
|  |  | 20,050 |  |  |  | (911 | ) |  |  | 19,139 |
Current contingent consideration |  |  | (759 | ) |  |  | — |  |  |  | (759 | )
Non-Current contingent consideration |  |  | (8,756 | ) |  |  | 547 |  |  |  | (8,209 | )
|  |  | (9,515 | ) |  |  | 547 |  |  |  | (8,968 | )
Accumulated losses |  |  | (68,253 | ) |  |  | (364 | ) |  |  | (68,617 | )
Total equity |  |  | 18,638 |  |  |  | (363 | ) |  |  | 18,275 |

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Notes to the financial statements
30 June 2024
Note 4. Restatement of comparatives (continued)

|  | 30 June 2022 |  |  | Increase/ (decrease) |  |  | 30 June 2022 Restated |
Consolidated statement of profit and loss |  |  |  |  |  |  |  |  |  |  |  |
Research and development expense |  |  | (20,252 | ) |  |  | 83 |  |  |  | (20,169 | )
General and administrative expense |  |  | (4,511 | ) |  |  | (602 | ) |  |  | (5,113 | )
Loss on revaluation of contingent consideration |  |  | (152 | ) |  |  | 152 |  |  |  | — |
Commercialisation expense |  |  | (127 | ) |  |  | — |  |  |  | (127 | )
Loss before income tax benefit |  |  | (25,016 | ) |  |  | (366 | ) |  |  | (25,382 | )
Income tax benefit |  |  | 368 |  |  |  | — |  |  |  | 368 |
Loss after income tax benefit |  |  | (24,648 | ) |  |  | (366 | ) |  |  | (25,014 | )
Impact on basic and diluted earnings per share increase/ (decrease) in earning per share |  |  |  |  |  |  |  |  |  |  |  |
|  | Cents |  |  | Cents |  |  | Cents |
Basic and diluted loss for the year attributable to equity holders |  | $ | (18.61 | ) |  | $ | (0.27 | ) |  | $ | (18.88 | )

Note 5. Reclassification of comparatives
During the preparation of the consolidated financial statements for the year ended 30 June 2023, a reclassification between borrowings and other assets was performed to better reflect the insurance funding premium utilized by the Company, a reclassification of
non-current
annual leave employee benefit to current employee benefits and a reclassification between loss on remeasurement of contingent consideration and general and administrative expense to accurately reflect the impact of the unwinding of discounting contingent consideration for paxalisib.

|  | 30 June 2022 Restated |  |  | Reclassification |  |  | 30 June 2022 Reclassified |
Other assets |  |  | 156 |  |  |  | 1,841 |  |  |  | 1,997 |
Borrowings |  |  | — |  |  |  | (1,841 | ) |  |  | (1,841 | )
Current employee benefits |  |  | 166 |  |  |  | 203 |  |  |  | 369 |
Non-current employee benefits |  |  | 319 |  |  |  | (202 | ) |  |  | 117 |
Loss on remeasurement of contingent consideration |  |  | 152 |  |  |  | (152 | ) |  |  | — |
General and administrative expense |  |  | (4,961 | ) |  |  | (152 | ) |  |  | (5,113 | )

Note 6. Revenue

|  | 2024 A$’000 |  |  | 2023 A$’000 |  |  | 2022 A$’000 |
Licensing revenue |  |  | 2,301 |  |  |  | — |  |  |  | — |
Sale of paxalisib |  |  | 7 |  |  |  | — |  |  |  | — |
|  |  | 2,308 |  |  |  | — |  |  |  | — |

Disaggregation of revenue
The disaggregation of revenue from contracts with customers is as follows:

|  | 2024 A$’000 |  |  | 2023 A$’000 |  |  | 2022 A$’000 |
Geographical regions |  |  |  |  |  |  |  |  |  |  |  |
South Korea |  |  | 2,308 |  |  |  | — |  |  |  | — |
|  |  | 2,308 |  |  |  | — |  |  |  | — |
Timing of revenue recognition |  |  |  |  |  |  |  |  |  |  |  |
Licensing revenue at a point in time |  |  | 2,301 |  |  |  | — |  |  |  | — |
Sale of paxalisib at a point in time |  |  | 7 |  |  |  | — |  |  |  | — |

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Notes to the financial statements
30 June 2024
Note 6. Revenue (continued)
License Agreement with Oasmia Pharmaceutical AB
In March 2021, the
C
ompany entered into an exclusive worldwide license agreement with Oasmia Pharmaceutical AB (“Osmia”), an innovation-focused specialty pharmaceutical company, for
Cantrixil (TRX-E-002 - 1), a clinical
stage drug candidate for the treatment of ovarian cancer. During fiscal
2021
, Oasmia made an upfront payment of US$
4
million with contingent milestones of up to US$
42
million and double-digit
royalties
on commercial sales.
License Agreement with Simcere Pharmaceutical Group Ltd.
In March 2021, the
C
ompany entered into a licensing agreement with Simcere Pharmaceutical Group LTD (“Simcere”) to develop and commercialize the
C
ompany’s investigational drug candidate,
paxalisib
, in Greater China. Under the terms of the agreement, Simcere assumed responsibility for the development, registration and commercialization of paxalisib in Greater China (a territory that includes Mainland China, Hong Kong, Macau and Taiwan). The
C
ompany received an upfront payment of US$11 million comprising US$7 million in cash and a US$4 million equity investment, priced at a 20% premium to recent trading. The
C
ompany will also receive contingent milestone payments of up to US$281 million for glioblastoma, with further milestones payable for indications beyond glioblastoma. Simcere will additionally pay
mid-teen
percentage royalties on commercial sales.
License Agreement with Sovargen Co Ltd.
In March 2024, the Company entered into a licensing agreement with Sovargen Co Ltd. (“Sovargen”) to develop and commercialize the Company’s
investigational drug candidate, paxalisib, for countries except mainland China, Hong Kong, Macao and Taiwan. Under the terms of the agreement, Sovargen assumed responsibility for the development, registration and commercialization of paxalisib in countries except for China, Hong Kong, Macao and Taiwan. The
C
ompany received an upfront payment of US$1.5 million. The
C
ompany will also receive contingent milestone payments of up to US$19 million upon achievement of development and regulatory milestones, and a percentage of
sub-licensing
revenues and royalties on net sales of products incorporating paxalisib.
During fiscal year 2024, the
C
ompany recognised A$2.3 million of revenue from the license agreements described in the above paragraphs in accordance with the terms of the agreements and revenue recognition policy in accordance with
note 2.
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Notes to the financial statements
30 June 2024
Note 7. Operating segments
Identification of reportable operating segments
The Consolidated Entity’s operating segment is based on the internal reports that are reviewed and used by the Board of Directors (being the Chief Operating Decision Makers (‘CODM’) in assessing performance and in determining the allocation of resources.
The Consolidated Entity operates in the pharmaceutical research and development business. There are no operating segments for which discrete financial information exists.
The information reported to the CODM, on at least a quarterly basis, is the consolidated results as shown in the statement of profit or loss and other comprehensive income and statement of financial position.
Note 8. Other income

|  | 2024 A$’000 |  |  | 2023 A$’000 |  |  | 2022 A$’000 |
Research and development rebate |  |  | 173 |  |  |  | — |  |  |  | — |
Subsidies and grants |  |  | — |  |  |  | — |  |  |  | 10 |
Bad debt recovery |  |  | — |  |  |  | — |  |  |  | 15 |
Other sundry income |  |  | — |  |  |  | 1 |  |  |  | — |
|  |  | 173 |  |  |  | 1 |  |  |  | 25 |

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Notes to the financial statements
30 June 2024
Note 9. Expenses

|  | 2024 A$’000 |  |  | 2023 A$’000 |  |  | 2022 restated A$’000 |
Research and development |  |  |  |  |  |  |  |  |  |  |  |
EVT-801 program costs |  |  | 5,277 |  |  |  | 5,060 |  |  |  | 2,520 |
Cantrixil program costs |  |  | 1 |  |  |  | 5 |  |  |  | 12 |
Paxalisib program costs |  |  | 7,551 |  |  |  | 5,618 |  |  |  | 13,713 |
Scientific Advisory Board costs |  |  | — |  |  |  | 31 |  |  |  | — |
Employee benefits expense - salaries & wages and staff benefits |  |  | 2,161 |  |  |  | 2,250 |  |  |  | 1,665 |
- superannuation |  |  | 36 |  |  |  | 29 |  |  |  | 25 |
- share based payments |  |  | 485 |  |  |  | 702 |  |  |  | 365 |
Total research & development (excluding amortisation) |  |  | 15,511 |  |  |  | 13,695 |  |  |  | 18,300 |
Amortisation |  |  |  |  |  |  |  |  |  |  |  |
Paxalisib licensing agreement |  |  | 1,084 |  |  |  | 1,084 |  |  |  | 1,084 |
Evotech licensing agreement |  |  | 785 |  |  |  | 785 |  |  |  | 785 |
Total amortisation |  |  | 1,869 |  |  |  | 1,869 |  |  |  | 1,869 |
Total research & development |  |  | 17,380 |  |  |  | 15,564 |  |  |  | 20,169 |
Net foreign exchange loss |  |  |  |  |  |  |  |  |  |  |  |
Net foreign exchange (gain) / loss |  |  | (20 | ) |  |  | 46 |  |  |  | (2,154 | )
Rental expense relating to operating leases |  |  |  |  |  |  |  |  |  |  |  |
Minimum lease payments |  |  | 124 |  |  |  | 152 |  |  |  | 73 |
Superannuation expense |  |  |  |  |  |  |  |  |  |  |  |
Defined contribution superannuation expense |  |  | 88 |  |  |  | 131 |  |  |  | 138 |
Employee benefits expense G&A |  |  |  |  |  |  |  |  |  |  |  |
- salaries & wages and staff benefits |  |  | 486 |  |  |  | 1,467 |  |  |  | 1,674 |
- superannuation |  |  | 52 |  |  |  | 102 |  |  |  | 129 |
- share based payments |  |  | 48 |  |  |  | 457 |  |  |  | 1,310 |
Total employee benefits expense G&A |  |  | 586 |  |  |  | 2,026 |  |  |  | 3,113 |

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Notes to the financial statements
30 June 2024
Note 10. Income taxes

|  | 2024 |  |  | 2023 |  |  | 2022 restated |
|  | A$’000 |  |  | A$’000 |  |  | A$’000 |
Numerical reconciliation of income tax benefit and tax at the statutory rate |  |  |  |  |  |  |  |  |  |  |  |
Loss before income tax benefit |  |  | (27,049 | ) |  |  | (20,736 | ) |  |  | (25,382 | )
Tax at the statutory tax rate of 25 % |  |  | (6,762 | ) |  |  | (5,184 | ) |  |  | (6,345 | )
Tax effect amounts which are not deductible/(taxable) in calculating taxable income: |  |  |  |  |  |  |  |  |  |  |  |
Research and d evelopment claim |  |  | — |  |  |  | — |  |  |  | — |
Amortisation of intangibles |  |  | 467 |  |  |  | 467 |  |  |  | 467 |
Employee option plan |  |  | 133 |  |  |  | 289 |  |  |  | 419 |
Gain/loss on revaluation of contingent consideration |  |  | (22 | ) |  |  | (847 | ) |  |  | 38 |
|  |  | (6,184) |  |  |  | (5,275) |  |  |  | (5,421) |
Adjustment recognised for prior periods |  |  | — |  |  |  | — |  |  |  | 16 |
Adjustment to deferred tax balances as a result of change in statutory tax rate |  |  | — |  |  |  | — |  |  |  | (113 | )
Tax losses and timing differences not recognised |  |  | 5,913 |  |  |  | 5,004 |  |  |  | 5,150 |
Income tax benefit |  |  | (271 | ) |  |  | (271 | ) |  |  | (368 | )

|  | 2024 A$’000 |  |  | 2023 A$’000 |  |  | 2022 restated A$’000 |
Tax losses not recognised |  |  |  |  |  |  |  |  |  |  |  |
Unused tax losses for which no deferred tax asset has been recogni s ed-Australia |  |  | 139,430 |  |  |  | 120,412 |  |  |  | 96,519 |
Potential tax benefit @ 25.0 % - Australia |  |  | 34,858 |  |  |  | 30,103 |  |  |  | 24,130 |
Unused tax losses for which no deferred tax asset has been recogni s ed US |  |  | 7,836 |  |  |  | 4,305 |  |  |  | 2,380 |
Potential tax benefit @ 21%-US |  |  | 1,646 |  |  |  | 904 |  |  |  | 500 |

Note 11. Current assets - cash and cash equivalents

|  | 2024 |  |  | 2023 |
|  | A$’000 |  |  | A$’000 |
Cash at bank and on hand |  |  | 1,657 |  |  |  | 5,241 |
|  |  | 1,657 |  |  |  | 5,241 |

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Notes to the financial statements
30 June 2024
Note 12. Trade and other receivables

|  | 2024 |  |  | 2023 |
|  | A$’000 |  |  | A$’000 |
Current assets |  |  |  |  |  |  |  |
Trade receivables |  |  | — |  |  |  | 1 |
GBM Agile deposit |  |  | 3,756 |  |  |  | 3,753 |
BAS receivables |  |  | 133 |  |  |  | 104 |
Deposits held |  |  | 8 |  |  |  | 41 |
|  |  | 3,897 |  |  |  | 3,899 |

The GBM Agile deposit was advanced to GCAR at the start of the GBM Agile trial, and is refundable if not utilized against trial expenses. The amount will be allocated against expenditure towards the latter end of the trial. Completion of the final analysis is expected in second half of 2024.
The Business Activity Statement (“BAS”) receivable consist of GST that is recoverable and refundable from the tax authority.
Note 13. Trade and other receivables -
non-current

|  | 2024 |  |  | 2023 |
|  | A$’000 |  |  | A$’000 |
Non-current assets |  |  |  |  |  |  |  |
Corporate credit card deposit |  |  | 40 |  |  |  | 43 |
|  |  | 40 |  |  |  | 43 |

Note 14. Other assets

|  | 2024 |  |  | 2023 |
|  | A$’000 |  |  | A$’000 |
Prepayments |  |  | 591 |  |  |  | 1,632 |

Other assets is comprised of this contains the prepayment of invoices in relation to the annual insurance renewal program and an offsetting borrowing for the funding of this prepayment in included in Borrowings - See Note 17 Borrowings.
Note 15. Intangibles

|  | Consolidated |
|  | 2024 A$’000 |  |  | 2023 A$’000 |
Licensing agreement - Paxalisib |  |  | 16,408 |  |  |  | 16,408 |
Less: Accumulated amortisation |  |  | (8,335 | ) |  |  | (7,251 | )
|  |  | 8,073 |  |  |  | 9,157 |
Licensing agreement - EVT-801 |  |  | 9,813 |  |  |  | 9,813 |
Less: Accumulated amortisation |  |  | (2,486 | ) |  |  | (1,701 | )
|  |  | 7,327 |  |  |  | 8,112 |
|  |  | 15,400 |  |  |  | 17,269 |

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Notes to the financial statements
30 June 2024
Note 15. Intangibles (continued)
Reconciliations
Reconciliations of the carrying values at the beginning and end of the current and previous financial year are set out below:

|  | EVT801 licensing agreement A$’000 |  |  | Paxalisib licensing agreement A$’000 |  |  | Total A$’000 |
Balance at 30 June 2022 restated |  |  | 8,897 |  |  |  | 10,242 |  |  |  | 19,139 |
Amortisation expense |  |  | (785 | ) |  |  | (1,085 | ) |  |  | (1,870 | )
Balance at 30 June 2023 |  |  | 8,112 |  |  |  | 9,157 |  |  |  | 17,269 |
Amortisation expense |  |  | (785 | ) |  |  | (1,084 | ) |  |  | (1,869 | )
Balance at 30 June 2024 |  |  | 7,327 |  |  |  | 8,073 |  |  |  | 15,400 |

Note 16. Trade and other payables

|  | 2024 |  |  | 2023 |
|  | A$’000 |  |  | A$’000 |
Trade payables |  |  | 4,548 |  |  |  | 857 |
Accrued payables |  |  | 10,519 |  |  |  | 3,472 |
|  |  | 15,067 |  |  |  | 4,329 |

Refer to Note 25 for further information on financial instruments.
Note 17. Borrowings
Current liabilities

|  | 2024 |  |  | 2023 |
|  | A$’000 |  |  | A$’000 |
Insurance premium funding |  |  | 634 |  |  |  | 1,796 |

Borrowings related to the annual insurance renewal program. An offsetting prepayment of insurance invoices is included in Prepayments - See Note 14 Other Assets.
On 23 October 2023, the Company entered into a securities purchase agreement with an accredited investor, pursuant to which the Company issued a six month unsecured convertible promissory note (the “Note”) in the principal amount of A$
776,670
(US$
500,000
). The Note bears interest at a rate of
10
% per annum. The investor called upon
50
% of the Note and cash of US$253,014 was paid, which represented US$
250,000
of principal and US$3,014 of interest (total payment of A$
371,802
). The investor exercised their option to receive the remaining 50% in ADSs on 20 December 2023, which resulted in 591,697 ADS to be issued. On 19 June 2024,
591,697
ADSs representing
5,916,970
ordinary shares were issued at a price of A$
0.0643
per ordinary share, which resulted in recognizing gain of A$25,174 through the fair value movement in liability between the exercise date and date the ADSs were issued.
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Notes to the financial statements
30 June 2024
Note 18. Employee benefits

|  | 2024 A$’000 |  |  | 2023 A$’000 |
Current Liabilities |  |  |  |  |  |  |  |
Employee benefits |  |  | — |  |  |  | 201 |
Annual leave |  |  | 365 |  |  |  | 489 |
|  |  | 365 |  |  |  | 690 |
Non-Current Liabilities |  |  |  |  |  |  |  |
Long service leave |  |  | 35 |  |  |  | 59 |
|  |  | 400 |  |  |  | 749 |

Note 19. Contingent consideration

|  | 2024 A$’000 |  |  | 2023 A$’000 |
Current Liabilities |  |  |  |  |  |  |  |
Contingent consideration - Paxalisib |  |  | — |  |  |  | 750 |
Contingent consideration - EVT801 |  |  | 3,253 |  |  |  | — |
|  |  | 3,253 |  |  |  | 750 |
Non-current Liabilities |  |  |  |  |  |  |  |
Contingent consideration - paxalisib |  |  | 1,266 |  |  |  | 654 |
Contingent consideration - EVT801 |  |  | 2,486 |  |  |  | 5,467 |
|  |  | 3,752 |  |  |  | 6,121 |
|  |  | 7,005 |  |  |  | 6,871 |

Reconciliations
Reconciliation of the balance at the beginning and end of the reporting period is set out below:

|  | Consolidated |
|  | 2024 |  |  | 2023 |
|  | $ |  |  | $ |
Contingent consideration at start of period (current and non-current) |  |  | 6,871 |  |  |  | 8,968 |
Payment of EVT801 milestone |  |  | — |  |  |  | — |
Interest accretion |  |  | 339 |  |  |  | 594 |
Effect of exchange rates on contingent consideration |  |  | (86 | ) |  |  | 697 |
Gain on remeasurement of contingent consideration |  |  | (119 | ) |  |  | (3,388 | )
|  |  | 7,005 |  |  |  | 6,871 |

Contingent consideration - paxalisib
During the 2017 financial year, the Consolidated Entity acquired the rights to develop and commercialize paxalisib, as part of a business combination.
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Notes to the financial statements
30 June 2024
Note 19. Contingent consideration (continued)
The acquisition contained four development contingent milestone payments, the first two milestone payment settlements being Kazia shares, and the third and fourth development milestone payment settlements either cash or Kazia shares at the discretion of Kazia. Milestones 1 and 4 have now been paid out, and Milestone 3 has lapsed. Milestone 2 comprises shares to the value of $1,250,000.
Each milestone payment is probability weighted for valuation purposes. Milestone 2 is contingent on the completion of a Phase II clinical trial of the molecule where such trial demonstrates a statistically significant improvement in progression-free survival or other approval endpoint indicated by the US Food and Drug Administration and was classified as a current liability as at 30 June 2023. Based on data received during June 2024, the Directors do not believe that this milestone payment will ultimately be due and payable and as such the probability weighting assigned in the current year has been reduced to nil (2023:60%).
Milestone 5 is a revenue based milestone contingent on net sales, which the Directors expect to ultimately be achieved and has an assigned probability of 100% (2023:57%). Milestone 5 is discounted to present value, using a discount rate of
9
%
(2023: 20%) per annum. The discount rate was considered at 30 June 2024 and revised to reflect an incremental borrowing rate at the date of acquisition revised to reflect recent market changes as the milestone payments are already probability weighted for valuation purposes.
Kazia is also required to pay royalties to Genentech in relation to net sales. These payments are related to future financial performance and are not considered as part of the consideration in relation to the Genentech agreement.
Contingent consideration - EVT801
The acquisition of EVT801 has been accounted for at cost, with milestones where the payment is considered probable being
recognised
as a current or
non-current
liability at period end,
based on
the estimated payment date. The key assumptions applied on initial recognition
are
reassessed in the
current periods
based on the revised timing of when milestone payments are expected to be paid. Milestone 3 is expected to be paid in 2H2024, milestones 4 & 5 are expected to be paid Q12025 and Q12027. Milestone 3 payment has a probability of 100% (2023: 100%), Milestone 4 payment has a probability of 80% (2023: 80%), and Milestone 5 payment has a probability of 63% (2023: 63%) of occurring. Milestones are discounted to present value, using a discount rate of 9% per annum (2023: 7% per annum). The discount rate
utilised is
based on the incremental borrowing rate at the time of acquisition and
i
s updated to reflect recent market
changes
. Milestones where the payment is not considered probable at year end have not been accounted for as a liability. The total amount of milestone payments not
recognised
at year end
totals
€300,500,000 (A$496,287,928) (2023: €300,500,000 (
A
$492,703,722)).
Note 20. Deferred tax

|  | 2024 |  |  | 2023 |
|  | A$’000 |  |  | A$’000 |
Non-current Liabilities |  |  |  |  |  |  |  |
Deferred tax liability associated with Licensing Agreement |  |  | 2,018 |  |  |  | 2,289 |

The Company completed an analysis of the availability of historical tax losses to offset the deferred tax liability concluding the historical tax losses are not expected to be available for offset against the deferred tax liability.
Note 21. Other financial liabilities

|  | Consolidated |
|  | June 2024 |  |  | June 2023 |
|  | A$’000 |  |  | A$’000 |
Prefunded and ordinary warrants at initial recognition |  | $ | 8,599 |  |  | $ | — |
Prefunded warrants exercised |  |  | (864 | ) |  |  | — |
Gain on remeasurement of financial liabilities |  |  | (1,257 | ) |  |  | — |
Prefunded and ordinary warrants at period end |  |  | 6,478 |  |  |  | — |

On
3
0
November, 2023, the Consolidated Entity entered into the Securities Purchase Agreement with an institutional investor, pursuant to which we issued and sold (A) in a registered direct offering, 2,620,000 ADSs and
pre-funded
warran
t
s to purchase up to 1,824,445 ADS, and (B) in a concurrent private placement, the Ordinary Warrants to purchase up to 4,444,445 ADSs, for nil consideration, which have an exercise price of US$0.583 per ADS, are exercisable immediately and will expire on 5 June, 2029.
The Ordinary Warrants were determined to be classified as a financial liability and a derivative under IAS 32 because they are denominated in a foreign currency, causing the value to vary with the USD/AUD exchange rate and the Consolidated Entity’s share price, requires a smaller net investment, and is settled at a future date. The initial fair value of the Ordinary Warrants was A$3,020,316. Additionally, as a part of the Securities Purchase Agreement, warrants were issued to the broker with an initial fair value of A$132,763.
Transaction costs of A$382,463 were incurred.
On
21
February
, 2024, the
pre-funded
warrants were exercised.
In connection with the Purchase Agreement with Alumni Capital described in Note 22, the Consolidated Entity issued warrants to purchase ADSs (“Warrant ADS”) that are accounted for at fair value through profit and loss.
The Warrant ADS were determined to be classified as a financial liability and a derivative under IAS 32 because they are denominated in a foreign currency, causing the value to vary with the USD/AUD exchange rate and the Consolidated Entity’s share price, requires a smaller net investment, and is settled at a future date.
The initial fair value of the warrants issued was A$5,445,887. Alumni Capital can purchase a number of Warrant ADSs from the Consolidated Entity, calculated as 5% of the total commitment amount minus any previous exercises, divided by the exercise price on the exercise date. The exercise price for each Warrant ADS is determined by dividing US$6,000,000 by the total number of ordinary shares on the exercise date, then multiplying by the current ADS to ordinary share ratio.
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Table of Contents
Notes to the financial statements
30 June 2024
Note 22. Equity - contributed equity

|  | 2024 |  |  | 2023 |  |  | 2022 |  |  | 2024 |  |  | 2023 |  |  | 2022 |
|  | Shares |  |  | Shares |  |  | Shares |  |  | A$‘000 |  |  | A$‘000 |  |  | A$‘000 |
Ordinary shares - fully paid |  |  | 332,850,784 |  |  |  | 228,029,114 |  |  |  | 138,755,376 |  |  |  | 101,638 |  |  |  | 97,452 |  |  |  | 84,480 |

Movements in ordinary share capital

Details |  | Date |  | Shares |  |  | Issue price |  |  | A$ |
Balance |  | 1 July 2021 |  |  | 132,012,209 |  |  |  |  |  |  |  | 80,290,062 |
Issued on conversion of options |  | 15 December 2021 |  |  | 25,000 |  |  | $ | 0.668 |  |  |  | 16,700 |
Conversion of Triaxial Convertible Note |  | 5 May 2022 |  |  | 1,855,357 |  |  | $ | 0.25 |  |  |  | 464,000 |
ATM issue of shares No. 1 |  | 24 May 2022 |  |  | 10,000 |  |  | $ | 0.826 |  |  |  | 8,256 |
ATM issue of shares No. 2 |  | 2 June 2022 |  |  | 10,000 |  |  | $ | 0.802 |  |  |  | 8,025 |
ATM issue of shares No. 3 |  | 6 June 2022 |  |  | 88,710 |  |  | $ | 0.837 |  |  |  | 74,258 |
ATM issue of shares No. 4 |  | 9 June 2022 |  |  | 603,500 |  |  | $ | 0.84 |  |  |  | 507,035 |
ATM issue of shares No. 5 |  | 14 June 2022 |  |  | 75,940 |  |  | $ | 0.824 |  |  |  | 62,583 |
ATM issue of shares No. 6 |  | 15 June 2022 |  |  | 2,000 |  |  | $ | 0.83 |  |  |  | 1,661 |
ATM issue of shares No. 7 |  | 20 June 2022 |  |  | 4,072,660 |  |  | $ | 0.869 |  |  |  | 3,540,403 |
Less: share issue transaction costs |  |  |  |  | — |  |  | $ | — |  |  |  | ( 492,735 | )
Balance |  | 30 June 2022 |  |  | 138,755,376 |  |  |  |  |  |  |  | 84,480,249 |

Balance |  | 1 July 2022 |  |  | 138,755,376 |  |  |  |  |  |  |  | 84,480,249 |
ATM issue of shares No. 8 |  | 7 July 2022 |  |  | 573,370 |  |  | $ | 0.7102 |  |  |  | 407,201 |
ATM issue of shares No. 9 |  | 8 August 2022 |  |  | 8,561,490 |  |  | $ | 0.3316 |  |  |  | 2,839,346 |
ATM issue of shares No. 10 |  | 9 August 2022 |  |  | 10,000 |  |  | $ | 0.2723 |  |  |  | 2,723 |
ATM issue of shares No. 11 |  | 10 August 2022 |  |  | 158,020 |  |  | $ | 0.2465 |  |  |  | 38,949 |
ATM issue of shares No. 12 |  | 11 August 2022 |  |  | 330,960 |  |  | $ | 0.2413 |  |  |  | 79,868 |
ATM issue of shares No. 13 |  | 12 August 2022 |  |  | 1,247,440 |  |  | $ | 0.2469 |  |  |  | 308,050 |
ATM issue of shares No. 14 |  | 12 September 2022 |  |  | 651,030 |  |  | $ | 0.2211 |  |  |  | 143,964 |
ATM issue of shares No. 15 |  | 13 September 2022 |  |  | 28,350 |  |  | $ | 0.2187 |  |  |  | 6,200 |
Shares issued to Scientific Advisory Board |  | 14 September 2022 |  |  | 60,000 |  |  | $ | 0.21 |  |  |  | 12,600 |
ATM issue of shares No. 16 |  | 7 October 2022 |  |  | 736,760 |  |  | $ | 0.1789 |  |  |  | 131,797 |
ATM issue of shares No. 17 |  | 28 October 2022 |  |  | 12,296,180 |  |  | $ | 0.1865 |  |  |  | 2,293,288 |
ATM issue of shares No. 18 |  | 11 January 2023 |  |  | 20,000 |  |  | $ | 0.138 |  |  |  | 2,761 |
Professional and sophisticated investors placement - 1st tranche |  | 16 January 2023 |  |  | 25,387,018 |  |  | $ | 0.11 |  |  |  | 2,792,572 |
Professional and sophisticated investors placement - 2nd tranche |  | 28 February 2023 |  |  | 15,522,075 |  |  | $ | 0.11 |  |  |  | 1,707,428 |
Share Placement Plan |  | 3 March 2023 |  |  | 23,691,045 |  |  | $ | 0.11 |  |  |  | 2,606,000 |
Less: share issue transaction costs |  |  |  |  |  |  |  |  |  |  |  |  | (400,750 | )
Balance |  | 30 June 2023 |  |  | 228,029,114 |  |  |  |  |  |  |  | 97,452,246 |
Balance |  | 01 July 2023 |  |  | 228,029,114 |  |  |  |  |  |  |  | 97,452,246 |
ATM issue of shares No. 19 |  | 06 July 2023 |  |  | 8,148,140 |  |  | $ | 0.19 |  |  |  | 1,512,523 |
ATM issue of shares No. 20 |  | 07 July 2023 |  |  | 157,120 |  |  | $ | 0.16 |  |  |  | 25,877 |
ATM issue of shares No. 21 |  | 03 August 2023 |  |  | 15,000 |  |  | $ | 0.17 |  |  |  | 2,519 |

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Table of Contents
Notes to the financial statements
30 June 2024
Note 22. Equity - contributed equity (continued)

ATM issue of shares No. 22 |  | 29 November 2023 |  |  | 1,066,070 |  |  | $ | 0.10 |  |  |  | 107,268 |
Registered Direct Offering |  | 05 December 2023 |  |  | 26,200,000 |  |  | $ | — |  |  |  | — |
ATM issue of shares No. 23 |  | 13 February 2024 |  |  | 25,910 |  |  | $ | 0.0466 |  |  |  | 1,207 |
ATM issue of shares No. 24 |  | 14 February 2024 |  |  | 319,650 |  |  | $ | 0.0464 |  |  |  | 14,834 |
ATM issue of shares No. 25 |  | 15 February 2024 |  |  | 2,195,980 |  |  | $ | 0.0468 |  |  |  | 102,825 |
ATM issue of shares No. 26 |  | 16 February 2024 |  |  | 205,260 |  |  | $ | 0.0614 |  |  |  | 12,597 |
Armistice warrants |  | 21 February 2024 |  |  | 18,244,450 |  |  | $ | 0.0450 |  |  |  | 892,655 |
ATM issue of shares No. 27 |  | 21 February 2024 |  |  | 8,626,580 |  |  | $ | 0.0595 |  |  |  | 513,584 |
ATM issue of shares No. 28 |  | 22 February 2024 |  |  | 316,540 |  |  | $ | 0.0461 |  |  |  | 14,584 |
ATM issue of shares No. 29 |  | 2 3 February 2024 |  |  | 304,860 |  |  | $ | 0.0464 |  |  |  | 14,147 |
ATM issue of shares No. 30 |  | 26 February 2024 |  |  | 250,000 |  |  | $ | 0.0460 |  |  |  | 11,502 |
ATM issue of shares No. 31 |  | 01 May 2024 |  |  | 2,112,560 |  |  | $ | 0.0478 |  |  |  | 100,961 |
ATM issue of shares No. 32 |  | 02 May 2024 |  |  | 375,410 |  |  | $ | 0.0457 |  |  |  | 17,147 |
ATM issue of shares No. 33 |  | 03 May 2024 |  |  | 288,900 |  |  | $ | 0.0469 |  |  |  | 13,544 |
ATM issue of shares No. 34 |  | 07 May 2024 |  |  | 790,100 |  |  | $ | 0.0456 |  |  |  | 36,024 |
ATM issue of shares No. 35 |  | 10 May 2024 |  |  | 20,000 |  |  | $ | 0.0455 |  |  |  | 910 |
ATM issue of shares No. 36 |  | 16 May 2024 |  |  | 242,170 |  |  | $ | 0.0450 |  |  |  | 10,891 |
Repayment of promissory note |  | 19 June 2024 |  |  | 5,916,970 |  |  | $ | 0.0643 |  |  |  | 380,223 |
Equity line of credit |  | 24 June 2024 |  |  | 29,000,000 |  |  | $ | 0.0268 |  |  |  | 776,264 |
Less: share issue transaction costs |  |  |  |  |  |  |  |  |  |  |  |  | (376,573 | )
Balance |  | 30 June 2024 |  |  | 332,850,784 |  |  |  |  |  |  |  | 101,637,758 |

For
the year ended 30 June 2024, Kazia issued 2,620,000 ADSs to an institutional investor (issued at US$0.45) under a securities purchase agreement (the “Securities Purchase Agreement”). As part of the Securities Purchase Agreement
,
the investor purchased 1,824,445
pre-funded
warrants (purchased for US$0.44 with an exercise price of US$0.01) and 4,444,445 free attaching warrants (with an exercise price of US$0.583). The gross proceeds received for this placement was US$1,981,756 (translated into A$3,020,315
) before transaction costs of A$382,463.
The warrants issued were determined to be a derivative financial liability and the accounting standards require that the proceeds received are first applied to the fair value of any derivative liability issued and that equity then represents the residual value in the transaction. The fair value of the warrants at issue date were determined to equal US$1,981,756 resulting in no residual equity value. Hence the equity reconciliation above shows the 26,200,000 shares issued but attributes no dollar value to the issue.
In February 2024, Armistice Capital exercised 1,824,445 prefunded warrants for a cash price of US$18,244
(translated into A$27,901)
and 18,244,450 ordinary shares were issued.
On 17 May 2024, the terms of the Securities Purchase Agreement were amended. in which the exercise price for the previously issued warrants was reduced to US$0.27 per ADS, and new warrants were issued to purchase up to 1,100,000 ADSs, with an exercise price of $0.27 per ADS. The original transaction resulted in the entire consideration being allocated to the derivative liability and all transaction fees associated with the transaction were expensed immediately. As such, the modification was directly adjusted through profit and loss along with any movement in the fair value of the derivative. The initial fair value of the newly issued warrants was A$232,488 and recorded as a derivative liability.
On 19 April 2024, Kazia entered into a purchase agreement (the “Purchase Agreement”) with Alumni Capital LP (“Alumni Capital”). Pursuant to the Purchase Agreement, the Company may sell to Alumni Capital up to an aggregate of $15,000,000, of ADSs from time to time
during
the term of the Purchase Agreement. During the fiscal year ended 30 June 2024, Kazia sold an aggregate amount of A$776,264 of ADSs under the Purchase Agreement.
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29

Table of Contents
Notes to the financial statements
30 June 2024
Note 22. Equity - contributed equity (continued)
Ordinary shares
Ordinary shares entitle the holder to participate in dividends and the proceeds on the winding up of the
C
ompany in proportion to the number of and amounts paid on the shares held. The fully paid ordinary shares have no par value and the
C
ompany does not have a limited amount of authorized capital.
On a show of hands every member present at a meeting in person or by proxy shall have one vote and upon a poll each share shall have one vote.
Share
buy-back
There is no current
on-market
share
buy-back.
Capital risk management
The Consolidated Entity’s objectives when managing capital are to safeguard its ability to continue as a going concern, so that it can provide returns for shareholders and benefits for other stakeholders and to maintain an optimum capital structure to reduce the cost of capital.
Capital is regarded as total equity, as recognized in the statement of financial position, plus net debt. Net debt is calculated as total borrowings less cash and cash equivalents.
The capital structure of the Consolidated Entity consists of cash and cash equivalents and equity attributable to equity holders. The overall strategy of the Consolidated Entity is to continue its drug development programs, which depends on raising sufficient funds, through a variety of sources including issuing of additional share capital, as may be required from time to time.
The capital risk management policy remains unchanged from the prior year.
Note 23. Equity - reserves

|  | 2024 |  |  | 2023 |  |  | 2022 |
|  | A$’000 |  |  | A$’000 |  |  | A$’000 |
Foreign currency reserve |  |  | (750 | ) |  |  | (742 | ) |  |  | (852 | )
Share-based payments reserve for Employee Share Option Plan |  |  | 4,225 |  |  |  | 4,423 |  |  |  | 3,264 |
|  |  | 3,475 |  |  |  | 3,681 |  |  |  | 2,412 |

Foreign currency translation reserve
The reserve is used to recognize exchange differences arising from translation of the consolidated financial statements of foreign operations to Australian dollars.
Share based payments reserve for Employee Share Option Plan
The reserve is used to recognize the value of equity benefits provided to employees and executive directors as part of their remuneration, and other parties as part of their compensation for services.
For the year ended 30 June 2024, there were A$0.5
million issuances from the share-based payment reserve for Employee Share Option plan and A$
0.7 million expirations and forfeitures.
Note 24. Equity - dividends
Dividends
There were
no
dividends paid, recommended or declared during the current or previous financial year.
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Table of Contents
Notes to the financial statements
30 June 2024
Note 25. Financial instruments
Financial risk management objectives
The Consolidated Entity’s activities expose it to a variety of financial risks: market risk, credit risk and liquidity risk. The Consolidated Entity uses different methods to measure and manage the different types of risks to which it is exposed. These methods include monitoring the levels of exposure to interest rates and foreign exchange, aging analysis and monitoring of specific credit allowances to manage credit risk, and, rolling cash flow forecasts to manage liquidity risk.
Market risk
Foreign currency risk
The Consolidated Entity operates internationally and is exposed to foreign exchange risk arising from various currency exposures, primarily with respect to the US dollars (‘USD’). Foreign exchange risk arises from future transactions and recognized assets and liabilities denominated in a currency that is not the entity’s functional currency and net investments in foreign operations.
Foreign currency risk is the risk that the fair value of future cash flows of a financial instrument will fluctuate because they are denominated in currencies that differ from the Company’s functional currency. The Company is exposed to foreign currency risk on fluctuations related to cash and cash equivalents, trade and other receivables, trade and other payables, and derivative financial liabilities on warrants that are denominated in foreign currencies. The Company has not used derivative instruments to reduce its exposure to foreign currency risk nor has it entered into foreign exchange contracts to hedge against gains or losses from foreign exchange fluctuations. Foreign subsidiaries with a functional currency of Australian Dollars (‘AUD’) have exposure to the local currency of these subsidiaries and any other currency these subsidiaries trade in.
The carrying amount of the Consolidated Entity’s foreign currency denominated financial assets and financial liabilities at the reporting date was as follows:

|  | 2024 |  |  | 2023 |
|  | US Dollar A$’000 |  |  | Euro A$’000 |  |  | Pound Sterling A$’000 |  |  | Singapore Dollar A$’000 |  |  | US Dollar A$’000 |  |  | Euro A$’000 |  |  | Pound Sterling A$’000 |  |  | Singapore Dollar A$’000 |
Cash and cash equivalents - current |  |  | 1,421 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 2,326 |  |  |  | — |  |  |  | — |  |  |  | — |
Trade and other receivables - current |  |  | 1,908 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
Trade and other payables - current |  |  | 942 |  |  |  | 7,320 |  |  |  | 18 |  |  |  | — |  |  |  | 1,135 |  |  |  | 2,710 |  |  |  | — |  |  |  | 1 |
Other financial liabilities |  |  | 6,478 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
|  |  | 10,749 |  |  |  | 7,320 |  |  |  | 18 |  |  |  | — |  |  |  | 3,461 |  |  |  | 2,710 |  |  |  | — |  |  |  | 1 |

The Consolidated Entity had net
liabilities
denominated in foreign currencies of A$11.4 million as at 2024 (2023: net assets A$2.2 million).
If all currencies
had
strengthened and weakened against the USD by 10% (2023:10% ) then this would have had the following impact:
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Table of Contents
Notes to the financial statements
30 June 2024
Note 25. Financial instruments (continued)

|  | AUD strengthened |  |  | AUD weakened |
Consolidated - 2024 |  | % change |  |  | Effect on profit before tax A$’000 |  |  | Effect on equity A$’000 |  |  | % change |  |  | Effect on profit before tax A$’000 |  |  | Effect on equity A$’000 |
US dollars |  |  | 10 | % |  |  | 142 |  |  |  | 142 |  |  |  | (10 | )% |  |  | (142 | ) |  |  | (142 | )
Euros |  |  | 10 | % |  |  | — |  |  |  | — |  |  |  | (10 | )% |  |  | — |  |  |  | — |
Pound Sterling |  |  | 10 | % |  |  | (2 | ) |  |  | (2 | ) |  |  | (10 | )% |  |  | 2 |  |  |  | 2 |
|  |  |  |  |  |  | 140 |  |  |  | 140 |  |  |  |  |  |  |  | (140 | ) |  |  | (140 | )
|  | AUD strengthened |  |  | AUD weakened |
Consolidated - 2023 |  | % change |  |  | Effect on profit before tax A$’000 |  |  | Effect on equity A$’000 |  |  | % change |  |  | Effect on profit before tax A$’000 |  |  | Effect on equity A$’000 |
US dollars |  |  | 10 | % |  |  | (494 | ) |  |  | (494 | ) |  |  | (10 | )% |  |  | 494 |  |  |  | 494 |
Euros |  |  | 10 | % |  |  | 271 |  |  |  | 271 |  |  |  | (10 | )% |  |  | (271 | ) |  |  | (271 | )
|  |  |  |  |  |  | (223 | ) |  |  | (223 | ) |  |  |  |  |  |  | 223 |  |  |  | 223 |

Price risk
The Consolidated Entity is not exposed to any significant price risk.
Interest rate risk
The Consolidated Entity’s exposure to market interest rates relate primarily to the investments of cash balances.
The Consolidated Entity has cash reserves held primarily in Australian dollars and United States dollars and places funds on deposit with financial institutions for periods generally not exceeding three months.
As at the reporting date, the Consolidated Entity had the following variable interest rate balances:

|  | 2024 |  |  | 2023 |
|  | Weighted average interest rate % |  |  | Balance A$’000 |  |  | Weighted average interest rate % |  |  | Balance A$’000 |
Cash and cash equivalents |  |  | 0.39 |  |  |  | 1,657 |  |  |  | 0.40 |  |  |  | 5,241 |
Net exposure to cash flow interest rate risk |  |  |  |  |  |  | 1,657 |  |  |  |  |  |  |  | 5,241 |

The Consolidated Entity has cash and cash equivalents totaling A$1.7 million (2023: A
$5.2
million). An increase/decrease in interest rates of
100
basis points
(2023:
100
basis points
) would have a favorable/adverse effect on profit before tax and equity of $16,575 (2023 $52,411) per annum. The percentage change is based on the expected volatility of interest rates using market data and analysts forecasts.
Credit risk
Credit risk refers to the risk that a counterparty will default on its contractual obligations resulting in financial loss to the Consolidated Entity. The Consolidated Entity is not exposed to significant credit risk on receivables.
The Consolidated Entity has adopted a lifetime expected loss allowance in estimating expected credit losses to trade receivables through the use of a provisions matrix using fixed rates of credit loss provisioning. These provisions are considered representative across all customers of the Consolidated Entity based on recent sales experience, historical collection rates and forward-looking information that is available.
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Table of Contents
Notes to the financial statements
30 June 2024
Note 25. Financial instruments (continued)
The Consolidated Entity places its cash deposits with high credit quality financial institutions and by policy, limits the amount of credit exposure to any single counterparty. The Consolidated Entity is averse to principal loss and ensures the safety and preservation of its invested funds by limiting default risk, market risk, and reinvestment risk.
The Consolidated Entity mitigates default risk by constantly positioning its portfolio to respond appropriately to a significant reduction in a credit rating of any financial institution.
Generally, trade receivables are written off when there is no reasonable expectation of recovery. Indicators of this include the failure of a debtor to engage in a repayment plan, no active enforcement activity and a failure to make contractual payments for a period greater than
one
year.
There are no significant concentrations of credit risk within the Consolidated Entity. The credit risk on liquid funds is limited as the counter parties are banks with high credit ratings.
Credit risk is managed by limiting the amount of credit exposure to any single counter-party for cash deposits.
Liquidity risk
The Consolidated Entity manages liquidity risk by maintaining adequate cash reserves and by continuously monitoring actual and forecast cash flows and matching the maturity profiles of financial assets and liabilities. In particular, contingent consideration may be satisfied either by payment of cash or by issue of shares, at the discretion of the entity.
Remaining contractual maturities
The following tables detail the Consolidated Entity’s remaining contractual maturity for its financial instrument liabilities. The tables have been drawn up based on the undiscounted cash flows of financial liabilities based on the earliest date on which the financial liabilities are required to be paid. The tables include both interest and principal cash flows disclosed as remaining contractual maturities and therefore these totals may differ from their carrying amount in the statement of financial position.

2024 |  | Weighted average interest rate % |  |  | 1 year or less A$’000 |  |  | Between 1 and 2 years A$’000 |  |  | Between 2 and 5 years A$’000 |  |  | Over 5 years A$’000 |  |  | Remaining contractual maturities A$’000 |  |  | Carrying Amount A$’000 |
Non-derivatives |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Trade payables |  |  | — |  |  |  | 4,548 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 4,548 |  |  |  | 4,548 |
Accrued payables |  |  | — |  |  |  | 10,519 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 10,519 |  |  |  | 10,519 |
Contingent consideration |  |  | — |  |  |  | 3,389 |  |  |  | — |  |  |  | 4,549 |  |  |  | — |  |  |  | 7,938 |  |  |  | 7,005 |
Derivatives |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Other financial liabilities |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 6,478 |  |  |  | — |  |  |  | 6,478 |  |  |  | 6,478 |
Total undiscounted financial liabilities |  |  |  |  |  |  | 18,456 |  |  |  | — |  |  |  | 11,027 |  |  |  | — |  |  |  | 29,483 |  |  |  | 28,550 |
2023 |  | Weighted average interest rate % |  |  | 1 year or less A$’000 |  |  | Between 1 and 2 years A$’000 |  |  | Between 2 and 5 years A$’000 |  |  | Over 5 years A$’000 |  |  | Remaining contractual maturities A$’000 |  |  | Carrying Amount A$’000 |
Non-derivatives |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Trade payables |  |  | — |  |  |  | 857 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 857 |  |  |  | 857 |
Accrued payables |  |  | — |  |  |  | 3,472 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 3,472 |  |  |  | 3,472 |
Contingent consideration |  |  | — |  |  |  | 750 |  |  |  | 4,303 |  |  |  | 3,099 |  |  |  | — |  |  |  | 8,152 |  |  |  | 6,871 |
Total undiscounted financial liabilities |  |  |  |  |  |  | 5,079 |  |  |  | 4,303 |  |  |  | 3,099 |  |  |  | — |  |  |  | 12,481 |  |  |  | 11,200 |

The cash flows in the maturity analysis above are not expected to occur significantly earlier than contractually disclosed above.
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Notes to the financial statements
30 June 2024
Note 26. Fair value measurement
Fair value hierarchy
The following tables detail the Consolidated Entity’s assets and liabilities, measured or disclosed at fair value, using a three level hierarchy, based on the lowest level of input that is significant to the entire fair
value
measurement, being:
Level 1: Quoted prices (unadjusted) in active markets for identical assets or liabilities that the entity can access at the measurement date
Level 2: Inputs other than quoted prices included within Level 1 that are observable for the asset or liability, either directly or indirectly
Level 3: Unobservable inputs for the asset or liability

Consolidated - 2024 |  | Level 1 A$‘000 |  |  | Level 2 A$‘000 |  |  | Level 3 A$‘000 |  |  | Total A$‘000 |
Liabilities |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contingent Consideration |  |  | — |  |  |  | — |  |  |  | 7,005 |  |  |  | 7,005 |
Warrant liability |  |  | — |  |  |  | — |  |  |  | 6,478 |  |  |  | 6,478 |
Total liabilities |  |  | — |  |  |  | — |  |  |  | 13,483 |  |  |  | 13,483 |
Consolidated - 2023 |  |  |  |  |  |  |  |  |  |  |  |
Liabilities |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contingent Consideration |  |  | — |  |  |  | — |  |  |  | 6,871 |  |  |  | 6,871 |
Total liabilities |  |  | — |  |  |  | — |  |  |  | 6,871 |  |  |  | 6,871 |

There were no transfers between levels during the financial year.
The fair value of contingent consideration related to the acquisition of Glioblast Pty Ltd and the license agreement is estimated by probability-weighting the expected future cash outflows, adjusting for risk and discounting.
The effects on the fair value of risk and uncertainty in the future cash flows are dealt with by adjusting the estimated cash flows rather than adjusting the discount rate. The estimated cashflows were adjusted based on the directors’ assessment of achieving contracted milestones as disclosed in Note 19. The probabilities used fell in the range of 0% to 100% and were informed by generally accepted industry probabilities of drugs achieving certain milestones in their progression towards registration.
The fair value of the warrant liability is determined using a Black-Scholes Model. Please refer to Note 21 for additional information regarding the private placement warrants.
Level 3 assets and liabilities
Movements in level 3 assets and liabilities during the current and previous financial year are set out below:

|  | Level 3 A$’000 |  |  | Total A$’000 |
Consolidated |  |  |  |  |  |  |  |
Balance at 30 June 2022 |  |  | 8,968 |  |  |  | 8,968 |
Losses recognized in profit or loss |  |  | (2,097 | ) |  |  | (2,097 | )
Balance at 30 June 2023 |  |  | 6,871 |  |  |  | 6,871 |
Issuance of warrants |  |  | 8,599 |  |  |  | 8,599 |
Exercise of warrants |  |  | (864 | ) |  |  | (864 | )
Gain recognized in profit or loss |  |  | (1,123 | ) |  |  | (1,123 | )
Balance at 30 June 2024 |  |  | 13,483 |  |  |  | 13,483 |

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Notes to the financial statements
30 June 2024
Note 27. Key management personnel disclosures
Compensation
The aggregate compensation made to directors and other members of key management personnel (‘KMP’) of the Consolidated Entity is set out below:

|  | 2024 A$ |  |  | 2023 A$ |  |  | 2022 A$ |
Short-term employee benefits |  |  | 1,962,563 |  |  |  | 3,148,514 |  |  |  | 2,589,088 |
Post-employment benefits |  |  | 72,784 |  |  |  | 149,626 |  |  |  | 115,950 |
Share-based payments |  |  | 353,437 |  |  |  | 1,045,860 |  |  |  | 1,559,930 |
|  |  | 2,388,784 |  |  |  | 4,344,000 |  |  |  | 4,264,968 |

Please refer to Note 28 for other transactions with key management personnel and their related parties.
Note 28. Related party transactions
Parent entity
Kazia Therapeutics Limited is the parent entity.
Subsidiaries
Interests in subsidiaries are set out in note 30.
Key management personnel
Disclosures relating to key management personnel are set out in note 27.
Transactions with related parties
There were no other transactions with KMP and their related parties.
Receivable from and payable to related parties
There were no trade receivables from or trade payables to related parties at the current and previous reporting date.
Loans to/from related parties
There were no loans to or from related parties at the current and previous reporting date.
Terms and conditions
All transactions were made on normal commercial terms and conditions and at market rates.
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Notes to the financial statements
30 June 2024
Note 29. Parent entity information
Set out below is the supplementary information about the parent entity.

|  | Parent |
|  | 2024 A$’000 |  |  | 2023 A$’000 |
Statement of profit or loss and other comprehensive income |  |  |  |  |  |  |  |
Loss after income tax |  |  | (24,008 | ) |  |  | (20,863 | )
Total comprehensive loss |  |  | (24,008 | ) |  |  | (20,863 | )
|  | 2024 A$’000 |  |  | 2023 A$’000 |
Statement of financial position |  |  |  |  |  |  |  |
Total current assets |  |  | 3,048 |  |  |  | 4,645 |
Total assets |  |  | 18,488 |  |  |  | 21,915 |
Total current liabilities |  |  | 25,529 |  |  |  | 7,003 |
Total liabilities |  |  | 31,335 |  |  |  | 15,472 |
Equity |  |  |  |  |  |  |  |
Contributed equity |  |  | 101,638 |  |  |  | 97,452 |
Reserves |  |  | 4,225 |  |  |  | 4,423 |
Accumulated losses |  |  | (118,710 | ) |  |  | (95,432 | )
Total equity |  |  | (12,847 | ) |  |  | 6,443 |

Reserves comprise Share Based Payments Reserve.
Contingent liabilities
The parent entity contingent liabilities as at 30 June 2024 and 30 June 2023 are as set out in note 19.
Capital commitments - Property, plant and equipment
The parent entity had no capital commitments for property, plant and equipment at as 30 June 2024 and 30 June 2023.
Significant accounting policies
The accounting policies of the parent entity are consistent with those of the Consolidated Entity, as disclosed in note 2, except for the following:

• |  | Investments in subsidiaries are accounted for at cost, less any impairment, in the parent entity.

• |  | Dividends received from subsidiaries are recognized as other income by the parent entity and its receipt may be an indicator of an impairment of the investment.

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Notes to the financial statements
30 June 2024
Note 30. Interests in subsidiaries
The consolidated financial statements incorporate the assets, liabilities and results of the following subsidiaries in accordance with the accounting policy described in note 2:

|  |  |  | Ownership interest |
Name |  | Principal place of business / Country of incorporation |  | 2024 % |  |  | 2023 % |
Kazia Laboratories Pty Ltd |  | Australia |  |  | 100 | % |  |  | 100 | %
Kazia Research Pty Ltd |  | Australia |  |  | 100 | % |  |  | 100 | %
Kazia Therapeutics Inc. |  | United States of America |  |  | 100 | % |  |  | 100 | %
Glioblast Pty Ltd |  | Australia |  |  | 100 | % |  |  | 100 | %

Note 31. Earnings per share

|  | 2024 A$‘000 |  |  | 2023 A$‘000 |  |  | 2022 A$‘000 |
Earnings per share for losses from continuing operations |  |  |  |  |  |  |  |  |  |  |  |
Loss after income tax attributable to the owners of Kazia Therapeutics Limited |  |  | (26,778 | ) |  |  | (20,465 | ) |  |  | (25,014 | )
Loss after income tax attributable to the owners of Kazia Therapeutics Limited |  |  | (26,778 | ) |  |  | (20,465 | ) |  |  | (25,014 | )
|  | Number |  |  | Number |  |  | Number |
Weighted average number of ordinary shares used in calculating basic and diluted earnings per share |  |  | 263,676,313 |  |  |  | 184,284,350 |  |  |  | 132,467,686 |
|  | Cents |  |  | Cents |  |  | Cents |
Basic and diluted earnings per share |  |  | (10.16 | ) |  |  | (11.23 | ) |  |  | (18.88 | )

The number of unissued shares under option that have been excluded from the diluted EPS are 36,180,000 (2024), 14,780,000 (2023), and 8,655,500 (2022).
Note 32. Share-based payments
All of the options set out below have been issued to employees and directors under the ESOP. During the financial year an expense of $532,597 (30 June 2023: $1,159,125) (
3
0
June 2022: $1,674,581) was recognized.

|  | Number of options 2024 - Ordinary shares |  |  | Weighted Average exercise price 2024 |  |  | Number of options 2023 - Ordinary shares |  |  | Weighted Average exercise price 2023 |
Outstanding at the beginning of the financial year |  |  | 14,780,000 |  |  | A$ | 0.63 |  |  |  | 8,655,500 |  |  | A$ | 1.28 |
Granted |  |  | — |  |  | A$ | — |  |  |  | 7,930,000 |  |  | A$ | 0.18 |
Forfeited |  |  | (3,400,000 | ) |  | A$ | 0.42 |  |  |  | (1,550,000 | ) |  | A$ | 1.90 |
Exercised |  |  | — |  |  | A$ | — |  |  |  | — |  |  | A$ | — |
Expired |  |  | (1,200,000 | ) |  | A$ | 0.49 |  |  |  | (255,500 | ) |  | A$ | 1.90 |
Outstanding at the end of the financial year |  |  | 10,180,000 |  |  | A$ | 0.72 |  |  |  | 14,780,000 |  |  | A$ | 0.63 |
Exercisable at the end of the financial year |  |  | 7,290,000 |  |  | A$ | 0.84 |  |  |  | 6,483,333 |  |  | A$ | 0.96 |

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Notes to the financial stat
em
ents
30 June 2024
Note 32. Share-based payments (cont
inued)

|  | Number of options 2024 - ADS |  |  | Weighted Average exercise price 2024 |  |  | Number of options 2023 - ADS |  |  | Weighted Average exercise price 2023 |
Outstanding at the beginning of the financial year |  |  | — |  |  | A$ | — |  |  |  | — |  |  | A$ | — |
Granted |  |  | 2,850,000 |  |  | A$ | 0.5600 |  |  |  | — |  |  | A$ | — |
Forfeited |  |  | (250,000 | ) |  | A$ | 0.5760 |  |  |  | — |  |  | A$ | — |
Exercised |  |  | — |  |  | A$ | — |  |  |  | — |  |  | A$ | — |
Expired |  |  | — |  |  | A$ | — |  |  |  | — |  |  | A$ | — |
Outstanding at the end of the financial year |  |  | 2,600,000 |  |  | A$ | 0.5580 |  |  |  | — |  |  | A$ | — |
Exercisable at the end of the financial year |  |  | — |  |  | A$ | — |  |  |  | — |  |  | A$ | — |

2024

Tranche |  | Grant date |  |  | Expiry date |  |  | Exercise price |  |  | Balance at the start of the year - Ordinary shares |  |  | Granted |  |  | Exercised |  |  | Expired / lapsed on termination of employment |  |  | Balance at the end of the year - Ordinary shares |
3 |  |  | 13/11/2019 |  |  |  | 04/01/2024 |  |  | A$ | 0.4925 |  |  |  | 1,200,000 |  |  |  | — |  |  |  | — |  |  |  | (1,200,000 | ) |  |  | — |
4 |  |  | 13/01/2020 |  |  |  | 13/01/2025 |  |  | A$ | 0.8812 |  |  |  | 187,500 |  |  |  | — |  |  |  | — |  |  |  | (50,000 | ) |  |  | 137,500 |
5 |  |  | 09/11/2020 |  |  |  | 09/11/2024 |  |  | A$ | 1.1320 |  |  |  | 1,200,000 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 1,200,000 |
6 |  |  | 09/11/2020 |  |  |  | 13/01/2025 |  |  | A$ | 0.8812 |  |  |  | 600,000 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 600,000 |
7 |  |  | 04/01/2021 |  |  |  | 04/01/2025 |  |  | A$ | 1.6900 |  |  |  | 187,500 |  |  |  | — |  |  |  | — |  |  |  | (50,000 | ) |  |  | 137,500 |
8 |  |  | 09/09/2021 |  |  |  | 26/06/2026 |  |  | A$ | 1.3650 |  |  |  | 100,000 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 100,000 |
9 |  |  | 16/11/2021 |  |  |  | 16/11/2025 |  |  | A$ | 1.6900 |  |  |  | 750,000 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 750,000 |
10 |  |  | 16/11/2021 |  |  |  | 16/11/2025 |  |  | A$ | 2.2400 |  |  |  | 500,000 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 500,000 |
11 |  |  | 16/11/2021 |  |  |  | 16/11/2025 |  |  | A$ | 1.5600 |  |  |  | 800,000 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 800,000 |
12 |  |  | 01/02/2022 |  |  |  | 01/02/2027 |  |  | A$ | 0.9400 |  |  |  | 800,000 |  |  |  | — |  |  |  | — |  |  |  | (800,000 | ) |  |  | — |
13 |  |  | 01/02/2022 |  |  |  | 01/02/2027 |  |  | A$ | 0.9400 |  |  |  | 425,000 |  |  |  | — |  |  |  | — |  |  |  | (100,000 | ) |  |  | 325,000 |
14 |  |  | 24/05/2022 |  |  |  | 24/05/2027 |  |  | A$ | 0.7800 |  |  |  | 100,000 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 100,000 |
15 |  |  | 03/03/2023 |  |  |  | 03/03/2027 |  |  | A$ | 0.1500 |  |  |  | 3,930,000 |  |  |  | — |  |  |  | — |  |  |  | (1,400,000 | ) |  |  | 2,530,000 |
16 |  |  | 03/05/2023 |  |  |  | 03/05/2027 |  |  | A$ | 0.1870 |  |  |  | 4,000,000 |  |  |  | — |  |  |  | — |  |  |  | (1,000,000 | ) |  |  | 3,000,000 |
|  |  |  |  |  |  |  |  |  |  |  |  |  |  | 14,780,000 |  |  |  | — |  |  |  | — |  |  |  | (4,600,000 | ) |  |  | 10,180,000 |
Weighted average exercise price |  |  | $ | 0.6292 |  |  | $ | — |  |  | $ | — |  |  | $ | 0.4349 |  |  | $ | 0.7207 |

At the end of the period the following outstanding options were vested and exerc
isab
le:
- Options in tranches 3 & 12 expired during the year
- Options in tranches 6 were vested and exercisable
- Options in tranches 4, 7, 8, & 9 were vested and exercisable to 69%, apart from those in the above table which have expired
- Options in tranche 5 were vested and exercisable to 75%, apart from those in the above table which have expired
- Options in tranches 10 & 15 were vested and exercisable as to 33%, apart from those in the above table which have expired
- Options in tranches 11, 14, & 16 were vested and exercisable as to 50%, apart from those in the above table which have expired
- Options in tranches 13 were vested and exercisable as to 35%, apart from those in the above table which have expired
The weighted average remaining contractual life of ordinary share options outstanding at 2024 is 2.00 years.
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Notes to the financial statements
30 June 2024
Note 32. Share-based payments (continued)

Tranche |  | Grant date |  |  | Expiry date |  |  | Exercise price |  |  | Balance at the start of the year - ADS |  |  | Granted |  |  | Exercised |  |  | Expired / lapsed on termination of employment |  |  | Balance at the end of the year - ADS |
17 |  |  | 22/04/2024 |  |  |  | 22/04/2029 |  |  | A$ | 0.5860 |  |  |  | — |  |  |  | 1,500,000 |  |  |  | — |  |  |  | — |  |  |  | 1,500,000 |
18 |  |  | 17/06/2024 |  |  |  | 17/06/2029 |  |  | A$ | 0.5130 |  |  |  | — |  |  |  | 1,100,000 |  |  |  | — |  |  |  | (250,000 | ) |  |  | 850,000 |
19 |  |  | 27/06/2024 |  |  |  | 27/06/2030 |  |  | A$ | 0.2970 |  |  |  | — |  |  |  | 250,000 |  |  |  | — |  |  |  | — |  |  |  | 250,000 |
|  |  |  |  |  |  |  |  |  |  |  |  |  |  | — |  |  |  | 2,850,000 |  |  |  | — |  |  |  | (250,000 | ) |  |  | 2,600,000 |
Weighted average exercise price |  |  |  |  |  |  | $ | 0.560 |  |  |  |  |  |  | $ | 0.576 |  |  | $ | 0.558 |

At the end of the period the following outstanding options were vested and exercisable:
- Options in tranche 17, 18, & 19 were unvested
The weighted average remaining contractual life of ADS share options outstanding at 30 June 2024 is
4.92
years.
2023

Tranche |  | Grant date |  |  | Expiry date |  |  | Exercise price |  |  | Balance at the start of the year - Ordinary shares |  |  | Granted |  |  | Exercised |  |  | Expired / lapsed on termination of employment |  |  | Balance at the end of the year - Ordinary Shares |
1 |  |  | 07/08/2017 |  |  |  | 07/08/2022 |  |  | A$ | 0.6700 |  |  |  | 15,500 |  |  |  | — |  |  |  | — |  |  |  | (15,500 | ) |  |  | — |
2 |  |  | 05/02/2018 |  |  |  | 05/02/2023 |  |  | A$ | 0.7802 |  |  |  | 240,000 |  |  |  | — |  |  |  | — |  |  |  | (240,000 | ) |  |  | — |
3 |  |  | 13/11/2019 |  |  |  | 04/01/2024 |  |  | A$ | 0.4925 |  |  |  | 1,200,000 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 1,200,000 |
4 |  |  | 13/01/2020 |  |  |  | 13/01/2025 |  |  | A$ | 0.8812 |  |  |  | 200,000 |  |  |  | — |  |  |  | — |  |  |  | (12,500 | ) |  |  | 187,500 |
5 |  |  | 09/11/2020 |  |  |  | 09/11/2024 |  |  | A$ | 1.1320 |  |  |  | 1,200,000 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 1,200,000 |
6 |  |  | 09/11/2020 |  |  |  | 13/01/2025 |  |  | A$ | 0.8812 |  |  |  | 800,000 |  |  |  | — |  |  |  | — |  |  |  | (200,000 | ) |  |  | 600,000 |
7 |  |  | 04/01/2021 |  |  |  | 04/01/2025 |  |  | A$ | 1.6900 |  |  |  | 200,000 |  |  |  | — |  |  |  | — |  |  |  | (12,500 | ) |  |  | 187,500 |
8 |  |  | 09/09/2021 |  |  |  | 26/06/2026 |  |  | A$ | 1.3650 |  |  |  | 100,000 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 100,000 |
9 |  |  | 16/11/2021 |  |  |  | 16/11/2025 |  |  | A$ | 1.6900 |  |  |  | 1,000,000 |  |  |  | — |  |  |  | — |  |  |  | (250,000 | ) |  |  | 750,000 |
10 |  |  | 16/11/2021 |  |  |  | 16/11/2025 |  |  | A$ | 2.2400 |  |  |  | 1,500,000 |  |  |  | — |  |  |  | — |  |  |  | (1,000,000 | ) |  |  | 500,000 |
11 |  |  | 16/11/2021 |  |  |  | 16/11/2025 |  |  | A$ | 1.5600 |  |  |  | 800,000 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 800,000 |
12 |  |  | 01/02/2022 |  |  |  | 01/02/2027 |  |  | A$ | 0.9400 |  |  |  | 800,000 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 800,000 |
13 |  |  | 01/02/2022 |  |  |  | 01/02/2027 |  |  | A$ | 0.9400 |  |  |  | 500,000 |  |  |  | — |  |  |  | — |  |  |  | (75,000 | ) |  |  | 425,000 |
14 |  |  | 24/05/2022 |  |  |  | 24/05/2027 |  |  | A$ | 0.7800 |  |  |  | 100,000 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 100,000 |
15 |  |  | 03/03/2023 |  |  |  | 03/03/2027 |  |  | A$ | 0.1500 |  |  |  | — |  |  |  | 3,930,000 |  |  |  | — |  |  |  | — |  |  |  | 3,930,000 |
16 |  |  | 05/03/2023 |  |  |  | 03/05/2027 |  |  | A$ | 0.1870 |  |  |  | — |  |  |  | 4,000,000 |  |  |  | — |  |  |  | — |  |  |  | 4,000,000 |
|  |  |  |  |  |  |  |  |  |  |  |  |  |  | 8,655,500 |  |  |  | 7,930,000 |  |  |  | — |  |  |  | (1,805,500 | ) |  |  | 14,780,000 |
Weighted average exercise price |  |  | $ | 1.2826 |  |  | $ | 0.1785 |  |  | $ | — |  |  | $ | 1.8977 |  |  | $ | 0.6292 |

At the end of the period the following outstanding options were vested and ex
erc
isable:
- Options in tranches 1 - 2 expired during the year
- Options in tranches 3 & 6 were vested and exercisable
- Options in tranches 4, 5, 7 & 9 were vested and exercisable to 75%, apart from those in the above table which have expired
- Options in tranche 8 were vested and exercisable to 50%, apart from those in the above table which have expired
- Options in tranches 10 & 16 were vested and exercisable as to 33%, apart from those in the above table which have expired
- Options in tranches 11, 12, 13 & 14 were vested and exercisable as to 25%, apart from those in the above table which have expired
- Options in tranche 15 were unvested
- Options in tranche 16 were 33% vested
The weighted average remaining contractual life of options outstanding at 30 June 2023 is
2.995
years.
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Table of Contents
Notes to the financial statements
30 June 2024
Note 32. Share-based payments (continued)
Employee share options
During the year ended 30 June 2024, 2,850,000 options have been issued to directors and employees by the Consolidated Entity pursuant to the Company’s Employee Share Option Plan.

• |  | Tranches 12 & 13 vests 25% 6 months from issue date and then in 3 amounts at 6 monthly intervals from the date of issue.

• |  | Tranches 14 vests 33% immediately then in two equal amounts annually from the date of grant.

• |  | Tranches 15 vests 6 months from issue date then in two equal amounts annually from the date of grant.

• |  | Tranches 16 vests 33% immediately then in two equal amounts annually from the date of grant.

• |  | Tranches 17 vests quarterly over 3 years from the date of the grant.

• |  | Tranches 18 vests quarterly over 3 years from the date of the grant.

• |  | Tranches 19 vests yearly over 4 years from the date of the grant

Vesting conditions for options within all tranches, is based on service period only; i.e. options will only vest if the option holder continues to be a full-time employee with the Company or an Associated Company during the vesting period relating to the option.
Conditions for an option to be
exercised:

• |  | The options must have vested;

• |  | Option holder must have provided the Company with an Exercise Notice and have paid the Exercise Price for the option;

• |  | The Exercise Notice must be for the exercise of at least the Minimum Number of Options; and

• |  | The Exercise Notice must have been provided to the Company and Exercise Price paid before the expiry of 4 years from the date the Option is issued.

Options Valuation
In order to obtain a fair valuation of these options, the following assumptions have been made:
The Black Scholes option valuation methodology has been used with the expectation that the majority of these options would be exercised towards the end of the option term. Inputs into the Black Scholes model includes the share price at grant date, exercise price, volatility, and the risk free rate of a five year Australian Government Bond on grant date.
Risk-free rate and grant date
For all tranches, the risk-free rate of a five-year Australian Government bond on grant date was used. Please refer to the table below for details. The above mentioned options have various vesting periods and exercising conditions. These options are unlisted as of 30 June 2024. No dividends are expected to be declared or paid by the Consolidated Entity during the terms of the options. The underlying expected volatility was determined by reference to historical data of the Company’s shares over a period of time. No special features inherent to the options granted were incorporated into measurement of fair value. Based on the above assumptions, the table below sets out the valuation for each tranche of options:
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Table of Contents
Notes to the financial statements
30 June 2024
Note 32. Share-based payments (continued)

Grant date |  | Expiry date |  | Share price at Grant Date |  | Exercise price |  | Volatility (%) |  | Dividend yield (%) |  |  | Risk free Rate (%) |  | Fair value per option |
13/11/2019 |  | 04/01/2024 |  | A $0.4100 |  | A $0.4925 |  | 74.50% |  |  | — |  |  | 1.95% |  | A$ | 0.1800 |
13/01/2020 |  | 13/01/2025 |  | A $0.6200 |  | A $0.8812 |  | 74.50% |  |  | — |  |  | 1.95% |  | A$ | 0.3400 |
09/11/2020 |  | 09/11/2024 |  | A $0.8900 |  | A $1.1320 |  | 90.00% |  |  | — |  |  | 0.10% |  | A$ | 0.4130 |
09/11/2020 |  | 13/01/2025 |  | A $0.8900 |  | A $0.8812 |  | 90.00% |  |  | — |  |  | 0.10% |  | A$ | 0.5030 |
04/01/2021 |  | 04/01/2025 |  | A $1.1850 |  | A $1.6900 |  | 90.00% |  |  | — |  |  | 0.19% |  | A$ | 0.6000 |
09/09/2021 |  | 26/06/2026 |  | A $1.4200 |  | A $1.3700 |  | 76.00% |  |  | — |  |  | 1.50% |  | A$ | 0.8800 |
16/11/2021 |  | 16/11/2025 |  | A $1.5700 |  | A $1.6900 |  | 76.00% |  |  | — |  |  | 1.50% |  | A$ | 0.8500 |
16/11/2021 |  | 16/11/2025 |  | A $1.5700 |  | A $2.2400 |  | 76.00% |  |  | — |  |  | 1.50% |  | A$ | 0.7500 |
16/11/2021 |  | 16/11/2025 |  | A $1.5700 |  | A $1.5600 |  | 76.00% |  |  | — |  |  | 1.50% |  | A$ | 0.9700 |
01/02/2022 |  | 01/02/2027 |  | A $0.9600 |  | A $0.9400 |  | 79.00% |  |  | — |  |  | 1.50% |  | A$ | 0.5900 |
01/02/2022 |  | 01/02/2027 |  | A $0.8000 |  | A $0.7800 |  | 44.00% |  |  | — |  |  | 2.95% |  | A$ | 0.6300 |
24/05/2022 |  | 24/05/2027 |  | A $0.1700 |  | A $0.1500 |  | 80.00% |  |  | — |  |  | 3.64% |  | A$ | 0.1014 |
03/03/2023 |  | 03/03/2027 |  | A $0.1700 |  | A $0.1500 |  | 80.00% |  |  | — |  |  | 3.64% |  | A$ | 0.1014 |
03/05/2023 |  | 03/05/2027 |  | A $0.1900 |  | A $0.1870 |  | 80.00% |  |  | — |  |  | 3.22% |  | A$ | 0.1111 |
22/04/2024 |  | 22/04/2029 |  | A $0.5860 |  | A $0.5860 |  | 95.00% |  |  | — |  |  | 3.96% |  | A$ | 0.4300 |
17/06/2024 |  | 17/06/2029 |  | A $0.3484 |  | A $0.5757 |  | 95.00% |  |  | — |  |  | 3.84% |  | A$ | 0.2300 |
27/06/2024 |  | 27/06/2030 |  | A $0.3461 |  | A $0.3311 |  | 95.00% |  |  | — |  |  | 4.17% |  | A$ | 0.2700 |

Note 33. Subsequent events
Fundraising Activities
From July 2024 through September 2024, the Consolidated E
ntity
raised total proceeds of A$5,348,262 using the ATM facility and continues to seek additional funding sources both in Australia and overseas. For the same period the Consolidated Entity also raised total proceeds of A$816,373 through its equity line of credit facility.
Change in ADS Ratio
The Company announced on October 15, 2024, that it had modified the provisions of its ADR program. The
previous conversion ratio of
10
Kazia Therapeutic Limited ordinary shares for each ADR share has become
100
Kazia
Therapeutic Limited ordinary shares for each ADR share. The change was effective from October 28, 2024. The change in the ADR ratio had no effect on the number of outstanding ordinary shares.
Phase II/III Clinical Trial Results for Paxalisib in Glioblastoma
The Company announced on July 10, 2024, promising results for paxalisib in treating newly diagnosed unmethylated glioblastoma (GBM) patients. The drug showed a
3.8-month
improvement in overall survival (OS), about a 33% increase compared to the standard of care (SOC). This outcome was consistent across two independent studies.
In a study involving 313 patients, those treated with paxalisib had a median OS of 14.77 months, compared to 13.84 months for SOC. A secondary analysis showed even better results, with paxalisib patients having a median OS of 15.54 months versus 11.89 months for SOC.
Paxalisib was well tolerated, with no new safety concerns. However, it did not show efficacy in recurrent GBM patients. Kazia plans to discuss these findings with the FDA to explore an accelerated approval pathway for paxalisib, which already has orphan drug and fast track designations.
No other matter or circumstance has arisen since 30 June 2024 that has significantly affected, or may significantly affect the Consolidated Entity’s operations, the results of those operations, or the Consolidated Entity’s state of affairs in future financial years.
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