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Income Taxes - Summary of Significant Components of Deferred Tax Assets and Liabilities for Federal and State Income Taxes (Details) - USD ($) $ in Thousands | Dec. 31, 2025 | Dec. 31, 2024 | Dec. 31, 2023
--- | --- | --- | ---
Deferred tax assets: |  |  |
Net operating loss carryforward | $ 66,024 | $ 53,485 |
Research tax credits | 12,169 | 11,353 |
Capitalized research and development expenses | 21,547 | 27,436 |
Lease liability | 6,605 | 7,137 |
Stock-based compensation | 2,243 | 2,256 |
Reserves and accruals | 551 | 1,585 |
Intangible assets | 110 | 127 |
Total deferred tax assets | 109,249 | 103,379 |
Less valuation allowance | (103,593) | (96,870) | $ (83,680)
Net deferred tax assets | 5,656 | 6,509 |
Deferred tax liabilities: |  |  |
Right-of-use assets | (5,532) | (6,159) |
Property and equipment | (73) | (311) |
Prepaid assets | (51) | (39) |
Total deferred tax liabilities | (5,656) | (6,509) |
Net deferred tax assets | $ 0 | $ 0 |

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