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Stock-Based Compensation (Tables)

12 Months Ended

Dec. 31, 2025

Share-Based Payment Arrangement [Abstract]

Summary of Stock Option Activity

The following table summarizes the stock option activity during the year ended December 31, 2025:

		Options Outstanding				Weighted-average Exercise Price				Weighted-average Remaining Contractual Term (in years)				Weighted-average Grant Date Fair Value				Aggregate Intrinsic Value (in thousands)
Outstanding at December 31, 2024			571,308			$	50.09				5.7							$	—
Granted			130,963			$	6.95							$	5.14
Exercised			—
Canceled/forfeited			(242,496	)		$	36.84
Outstanding at December 31, 2025			459,775			$	6.93				6.1							$	12
Exercisable at December 31, 2025			354,334			$	7.37				5.2							$	9
Vested or expected to vest at December 31, 2025			459,775			$	6.93				6.1							$	12

Summary of Fair Value of Option Grant Estimated Using Black-Scholes Option-Pricing Model

The fair value of each option grant was estimated on the date of grant using the Black-Scholes option-pricing model with the following assumptions:

	Years Ended December 31,
	2025					2024
Expected volatility		87-91			%	98-105			%
Risk-free interest rate		3.8-4.2			%	3.7-4.7			%
Expected option life (in years)		5.2-6.1				5.2-6.1
Expected dividend yield			—		%		—		%
Fair value per share of common stock		$5.44 - $9.76				$11.22-$25.40

Summary of Components of Stock-Based Compensation Expense Recognized

The following table summarizes the components of stock-based compensation expense recognized in the Company’s statement of operations and comprehensive loss (in thousands):

		Years Ended December 31,
		2025				2024
Research and development		$	1,162			$	3,152
General and administrative			1,620				4,255
Total		$	2,782			$	7,407

Summary of Restricted Stock Awards Activity

The following table summarizes the activity of the restricted stock units during the year ended December 31, 2025:

		RSU Outstanding				Weighted-average Grant Date Fair Value
Outstanding at December 31, 2024			—			$	—
Granted			249,500			$	5.61
Vested			—			$	—
Canceled/forfeited			—			$	—
Outstanding at December 31, 2025			249,500			$	5.61

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Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement.

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-Topic 718
-SubTopic 10
-Section 50
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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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Disclosure of the number and weighted-average grant date fair value for restricted stock and restricted stock units that were outstanding at the beginning and end of the year, and the number of restricted stock and restricted stock units that were granted, vested, or forfeited during the year.

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