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Income Taxes (Tables)

12 Months Ended

Dec. 31, 2025

Income Tax Disclosure [Abstract]

Summary of Income (Loss) Before Provision for Income Taxes

For financial reporting purposes, income (loss) before provision for income taxes, includes the following components (in thousands):
 

		Years Ended December 31,
		2025				2024
Domestic		$	(31,885	)		$	(63,118	)
Foreign			(1,491	)			—
Loss before income taxes		$	(33,376	)		$	(63,118	)

Summary of Reconciliation of Effective Tax Rate and Federal Statutory Tax Rate

A reconciliation of the Company’s effective tax rate and federal statutory tax rate is summarized as follows (in thousands):

		Years Ended December 31,
		2025								2024
Federal income tax provision at statutory rate		$	(7,009	)			21.0	%		$	(13,255	)			21.0	%
Foreign tax effects			(161	)			0.5	%			—				—	%
Tax credits:
Research and development			(513	)			1.5	%			(1,439	)			2.3	%
Change in valuation allowance			6,571				(19.7	%)			12,832				(20.3	%)
Nontaxable or nondeductible items:
Stock-based compensation			620				(1.9	%)			1,830				(2.9	%)
Other			492				(1.4	%)			32				(0.1	%)
Effective income tax rate		$	—				—	%		$	—				—	%

Summary of Significant Components of Deferred Tax Assets and Liabilities for Federal and State Income Taxes

Significant components of our deferred tax assets for federal and state income taxes are as follows (in thousands):

		December 31,
		2025				2024
Deferred tax assets:
Net operating loss carryforward		$	66,024			$	53,485
Research tax credits			12,169				11,353
Capitalized research and development expenses			21,547				27,436
Lease liability			6,605				7,137
Stock-based compensation			2,243				2,256
Reserves and accruals			551				1,585
Intangible assets			110				127
Total deferred tax assets			109,249				103,379
Less valuation allowance			(103,593	)			(96,870	)
Net deferred tax assets			5,656				6,509
Deferred tax liabilities:
Right-of-use assets			(5,532	)			(6,159	)
Property and equipment			(73	)			(311	)
Prepaid assets			(51	)			(39	)
Total deferred tax liabilities			(5,656	)			(6,509	)
Net deferred tax assets		$	—			$	—

Schedule of Reconciliation of Change in Valuation Allowance

The following table presents a reconciliation of the total change in the valuation allowance (in thousands):

		Years Ended December 31,
		2025				2024
Balance at beginning of period		$	96,870			$	83,680
Change charged to income tax expense			6,723				13,190
Balance at end of period		$	103,593			$	96,870

Summary of Gross Unrecognized Tax Benefits

The following table summarizes the activity in the Company’s gross unrecognized tax benefits (in thousands):

		Years Ended December 31,
		2025				2024
Balance at beginning of period		$	23,832			$	18,748
Decrease related to prior year positions			—				—
Increase related to current year positions			2,943				5,084
Balance at end of period		$	26,775			$	23,832

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Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

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Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations.

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Tabular disclosure of income before income tax between domestic and foreign jurisdictions.

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Tabular disclosure of valuation allowances to reduce deferred tax assets to net realizable value, including identification of the deferred tax asset more likely than not will not be fully realized and the corresponding amount of the valuation allowance.

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