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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2025
Dec. 31, 2024
Income Statement [Abstract]    
Collaboration revenue $ 7,695 $ 7,690
Operating expenses:    
Research and development 28,533 57,469
General and administrative 13,795 18,457
Restructuring charges 1,480 3,343
Impairment charges 0 1,469
Total operating expense 43,808 80,738
Loss from operations (36,113) (73,048)
Other income (expense), net    
Interest income, net 2,496 5,255
Other income, net 241 4,675
Total other income, net 2,737 9,930
Net loss (33,376) (63,118)
Net unrealized (loss) gain on marketable securities (118) 60
Comprehensive loss $ (33,494) $ (63,058)
Net loss per share, basic $ (17.85) $ (33.06)
Net loss per share, diluted $ (17.85) $ (33.06)
Weighted-average shares outstanding, basic 1,869,924 1,909,225
Weighted-average shares outstanding, diluted 1,869,924 1,909,225