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Note 12 - Stockholders' Equity (Tables)
9 Months Ended
Sep. 30, 2021
Notes Tables  
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
  

Three Months Ended September 30,

  

Nine Months Ended September 30,

 
  

2021

  

2020

  

2021

  

2020

 

Cost of product sales

 $14  $23  $61  $67 

Research and development cost

  11   24   64   124 

General and administrative expense

  375   473   1,573   1,841 

Total

 $400  $520  $1,698  $2,032