<SEC-DOCUMENT>0001213900-20-035602.txt : 20201106
<SEC-HEADER>0001213900-20-035602.hdr.sgml : 20201106
<ACCEPTANCE-DATETIME>20201106163139
ACCESSION NUMBER:		0001213900-20-035602
CONFORMED SUBMISSION TYPE:	SC 13G
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20201106
DATE AS OF CHANGE:		20201106
GROUP MEMBERS:		VIVO OPPORTUNITY, LLC

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ESSA Pharma Inc.
		CENTRAL INDEX KEY:			0001633932
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			A1
		FISCAL YEAR END:			0930

	FILING VALUES:
		FORM TYPE:		SC 13G
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-88939
		FILM NUMBER:		201294892

	BUSINESS ADDRESS:	
		STREET 1:		SUITE 720
		STREET 2:		999 WEST BROADWAY
		CITY:			VANCOUVER
		STATE:			A1
		ZIP:			V5Z 1K5
		BUSINESS PHONE:		(778) 331-0962

	MAIL ADDRESS:	
		STREET 1:		SUITE 720
		STREET 2:		999 WEST BROADWAY
		CITY:			VANCOUVER
		STATE:			A1
		ZIP:			V5Z 1K5

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Vivo Capital IX, LLC
		CENTRAL INDEX KEY:			0001750698
		IRS NUMBER:				824768569
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G

	BUSINESS ADDRESS:	
		STREET 1:		192 LYTTON AVENUE
		CITY:			PALO ALTO
		STATE:			CA
		ZIP:			94301
		BUSINESS PHONE:		6506880818

	MAIL ADDRESS:	
		STREET 1:		192 LYTTON AVENUE
		CITY:			PALO ALTO
		STATE:			CA
		ZIP:			94301
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G
<SEQUENCE>1
<FILENAME>ea129448-sc13gvivo9_essa.htm
<DESCRIPTION>SCHEDULE 13G
<TEXT>
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<P STYLE="text-align: center; margin-top: 0; margin-bottom: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>UNITED STATES</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>SECURITIES AND EXCHANGE
COMMISSION</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Washington, D.C. 20549</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><FONT STYLE="font-size: 12pt"><B>SCHEDULE
13G</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Under the Securities
Exchange Act of 1934</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>(Amendment No. )*</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>ESSA Pharma Inc.</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">(Name of Issuer)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Common Stock, without par value</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">(Title of Class of Securities)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>29668H104</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">(CUSIP Number)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>October 29, 2020</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">(Date of Event which Requires Filing of
this Statement)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 1.8pt 0pt 0; text-align: justify">Check the appropriate box to
designate the rule pursuant to which this Schedule is filed:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 1.8pt 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in; text-align: left">&#9744;</TD><TD STYLE="text-align: justify">Rule&nbsp;13d-1(b)</TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 1.8pt 0pt 0; text-align: justify">&nbsp;</P>

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<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in; text-align: left">&#9746;</TD><TD STYLE="text-align: justify">Rule&nbsp;13d-1(c)</TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 1.8pt 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in; text-align: left">&#9744;</TD><TD STYLE="text-align: justify">Rule&nbsp;13d-1(d)</TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 1.8pt 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 1.8pt 0pt 0; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 1.8pt 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in; text-align: left">*</TD><TD STYLE="text-align: left">The remainder of this cover page shall be filled out for
a reporting person&rsquo;s initial filing on this form with respect to the subject class of securities, and for any subsequent
amendment containing information which would alter the disclosures provided in a prior cover page.</TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 2.15pt 0pt 9.35pt; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-indent: 0; text-align: left">The information required
on the remainder of this cover page shall not be deemed to be &ldquo;filed&rdquo; for the purpose of Section&nbsp;18 of the Securities
Exchange Act of 1934 (&ldquo;Act&rdquo;) or otherwise subject to the liabilities of that section of the Act but shall be subject
to all other provisions of the Act (however, see the Notes).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 2.15pt 0pt 9.35pt; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 2.15pt 0pt 9.35pt; text-align: justify"></P>

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<TR STYLE="vertical-align: top">
    <TD COLSPAN="5" STYLE="padding: 3pt 5.4pt; border: Black 1.5pt solid">CUSIP No. 29668H104</TD></TR>
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="2" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid; border-left: Black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 12pt"><B>1</B></FONT></TD>
    <TD COLSPAN="3" STYLE="padding: 3pt 5.4pt"><FONT STYLE="font-size: 10pt">NAMES OF REPORTING PERSONS</FONT></TD>
    <TD STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="3" STYLE="padding: 3pt 5.4pt; border-bottom: Black 1.5pt solid"><B>Vivo Capital IX, LLC</B></TD>
    <TD STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="3" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid; border-left: Black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 12pt"><B>2</B></FONT></TD>
    <TD COLSPAN="4" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="4" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">(a)&nbsp;&#9746;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="4" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">(b)&nbsp;&#9744;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="2" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid; border-left: Black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 12pt"><B>3</B></FONT></TD>
    <TD COLSPAN="4" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">SEC USE ONLY</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="4" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="2" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid; border-left: Black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 12pt"><B>4</B></FONT></TD>
    <TD COLSPAN="4" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">CITIZENSHIP OR PLACE OF ORGANIZATION</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="4" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid"><B>Delaware</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" ROWSPAN="8" STYLE="vertical-align: middle; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid; border-left: Black 1.5pt solid; padding: 3pt 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt">NUMBER OF<BR>
 SHARES<BR>
 BENEFICIALLY<BR>
 OWNED BY<BR>
 EACH<BR>
 REPORTING<BR>
 PERSON<BR>
WITH</FONT></TD>
    <TD ROWSPAN="2" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 12pt"><B>5</B></FONT></TD>
    <TD COLSPAN="2" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">SOLE VOTING POWER</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid"><B>314,739 <SUP>(1)</SUP></B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="2" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 12pt"><B>6</B></FONT></TD>
    <TD COLSPAN="2" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">SHARED VOTING POWER</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid"><B>0</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="2" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 12pt"><B>7</B></FONT></TD>
    <TD COLSPAN="2" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">SOLE DISPOSITIVE POWER</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid"><B>314,739 <SUP>(1)</SUP></B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="2" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 12pt"><B>8</B></FONT></TD>
    <TD COLSPAN="2" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">SHARED DISPOSITIVE POWER</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid"><B>0</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="2" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid; border-left: Black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 12pt"><B>9</B></FONT></TD>
    <TD COLSPAN="4" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="4" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid"><B>314,739 <SUP>(1)</SUP></B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="2" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid; border-left: Black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 12pt"><B>10</B></FONT></TD>
    <TD COLSPAN="4" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See Instructions)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="4" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid">&#9744;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="2" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid; border-left: Black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 12pt"><B>11</B></FONT></TD>
    <TD COLSPAN="4" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="4" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid"><B>1.0% <SUP>(2)</SUP></B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="2" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid; border-left: Black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 12pt"><B>12</B></FONT></TD>
    <TD COLSPAN="4" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">TYPE OF REPORTING PERSON (See Instructions)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="4" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid"><B>OO</B></TD></TR>
<TR>
    <TD STYLE="padding: 3pt 5.4pt; width: 6%">&nbsp;</TD>
    <TD STYLE="padding: 3pt 5.4pt; width: 8%">&nbsp;</TD>
    <TD STYLE="padding: 3pt 5.4pt; width: 6%">&nbsp;</TD>
    <TD STYLE="padding: 3pt 5.4pt; width: 50%">&nbsp;</TD>
    <TD STYLE="padding: 3pt 5.4pt; width: 30%">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt"></P>

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<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in; text-align: left"><SUP>(1)</SUP></TD><TD STYLE="text-align: left">The shares of common stock, without par value (the &ldquo;Common
Stock&rdquo;) of ESSA Pharma Inc. (the &ldquo;Issuer&rdquo;) are held of record by Vivo Capital Fund IX, L.P. Vivo Capital IX,
LLC is the general partner of Vivo Capital Fund IX, L.P.</TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in; text-align: left"><SUP>(2)</SUP></TD><TD STYLE="text-align: justify">Based on 32,064,411 shares of Common Stock of the Issuer
outstanding as of November 3, 2020.</TD>
</TR></TABLE>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>


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    <TD COLSPAN="5" STYLE="padding: 3pt 5.4pt; border: Black 1.5pt solid">CUSIP No. 29668H104</TD></TR>
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="2" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid; border-left: Black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 12pt"><B>1</B></FONT></TD>
    <TD COLSPAN="3" STYLE="padding: 3pt 5.4pt"><FONT STYLE="font-size: 10pt">NAMES OF REPORTING PERSONS</FONT></TD>
    <TD STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="3" STYLE="padding: 3pt 5.4pt; border-bottom: Black 1.5pt solid"><B>Vivo Opportunity, LLC</B></TD>
    <TD STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="3" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid; border-left: Black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 12pt"><B>2</B></FONT></TD>
    <TD COLSPAN="4" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="4" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">(a)&nbsp;&#9746;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="4" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">(b)&nbsp;&#9744;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="2" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid; border-left: Black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 12pt"><B>3</B></FONT></TD>
    <TD COLSPAN="4" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">SEC USE ONLY</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="4" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="2" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid; border-left: Black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 12pt"><B>4</B></FONT></TD>
    <TD COLSPAN="4" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">CITIZENSHIP OR PLACE OF ORGANIZATION</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="4" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid"><B>Delaware</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" ROWSPAN="8" STYLE="vertical-align: middle; padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid; border-left: Black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 10pt">NUMBER OF<BR>
 SHARES<BR>
 BENEFICIALLY<BR>
 OWNED BY<BR>
 EACH<BR>
 REPORTING<BR>
 PERSON<BR>
WITH</FONT></TD>
    <TD ROWSPAN="2" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 12pt"><B>5</B></FONT></TD>
    <TD COLSPAN="2" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">SOLE VOTING POWER</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid"><B>1,410,514 <SUP>(1)</SUP></B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="2" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 12pt"><B>6</B></FONT></TD>
    <TD COLSPAN="2" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">SHARED VOTING POWER</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid"><B>0</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="2" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 12pt"><B>7</B></FONT></TD>
    <TD COLSPAN="2" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">SOLE DISPOSITIVE POWER</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid"><B>1,410,514 <SUP>(1)</SUP></B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="2" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 12pt"><B>8</B></FONT></TD>
    <TD COLSPAN="2" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">SHARED DISPOSITIVE POWER</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid"><B>0</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="2" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid; border-left: Black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 12pt"><B>9</B></FONT></TD>
    <TD COLSPAN="4" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="4" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid"><B>1,410,514 <SUP>(1)</SUP></B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="2" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid; border-left: Black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 12pt"><B>10</B></FONT></TD>
    <TD COLSPAN="4" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See Instructions)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="4" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid">&#9744;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="2" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid; border-left: Black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 12pt"><B>11</B></FONT></TD>
    <TD COLSPAN="4" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="4" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid"><B>4.4 % <SUP>(2)</SUP></B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="2" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid; border-left: Black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 12pt"><B>12</B></FONT></TD>
    <TD COLSPAN="4" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">TYPE OF REPORTING PERSON (See Instructions)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="4" STYLE="padding: 3pt 5.4pt; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid"><B>OO</B></TD></TR>
<TR>
    <TD STYLE="padding: 3pt 5.4pt; width: 6%">&nbsp;</TD>
    <TD STYLE="padding: 3pt 5.4pt; width: 8%">&nbsp;</TD>
    <TD STYLE="padding: 3pt 5.4pt; width: 6%">&nbsp;</TD>
    <TD STYLE="padding: 3pt 5.4pt; width: 50%">&nbsp;</TD>
    <TD STYLE="padding: 3pt 5.4pt; width: 30%">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in; text-align: left"><SUP>(1)</SUP></TD><TD STYLE="text-align: left">The shares of Common Stock of the Issuer are held of record
by Vivo Opportunity Fund, L.P. Vivo Opportunity, LLC is the general partner of Vivo Opportunity Fund, L.P.</TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt"><SUP></SUP></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in; text-align: left"><SUP>(2)</SUP></TD><TD STYLE="text-align: left">Based on 32,064,411 shares of Common Stock of the Issuer
outstanding as of November 3, 2020.</TD>
</TR></TABLE>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>


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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

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<TD STYLE="width: 0%"></TD><TD STYLE="width: 63pt; text-align: left"><FONT STYLE="font-variant: small-caps">Item 1</FONT>. (a)</TD><TD STYLE="text-align: justify"><FONT STYLE="font-variant: small-caps">Name of Issuer</FONT>:</TD>
</TR></TABLE>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in"><FONT STYLE="font-style: normal">&nbsp;</FONT></P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 63pt"><FONT STYLE="font-style: normal">ESSA
Pharma Inc.</FONT></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 63pt; text-indent: -63pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 36pt"></TD><TD STYLE="width: 27pt">(b)</TD><TD><FONT STYLE="font-variant: small-caps">Address of Issuer&rsquo;s Principal Executive Offices:</FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 17.65pt; text-indent: 45.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 17.65pt; text-indent: 45.35pt">Suite 720, 999 West Broadway,
Vancouver, British Columbia, Canada, V5Z 1K5</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 63pt; text-indent: -63pt"><FONT STYLE="font-variant: small-caps">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 63pt"><FONT STYLE="font-variant: small-caps">Item </FONT>2. (a)</TD><TD><FONT STYLE="font-variant: small-caps">Name of Person Filing:</FONT></TD></TR></TABLE>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in"><FONT STYLE="font-style: normal">&nbsp;</FONT></P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in"><FONT STYLE="font-style: normal">This
Schedule 13G is filed jointly by Vivo Capital IX, LLC and Vivo Opportunity, LLC. Vivo Capital IX, LLC and Vivo Opportunity, LLC
have entered into a Joint Filing Agreement, a copy of which is filed with this Schedule 13G as <A HREF="#a_001">Exhibit 99.1</A>, pursuant to which
they have agreed to file this Schedule 13G jointly in accordance with the provisions of Rule 13d-1(k) of the Securities Exchange
Act of 1934, as amended.</FONT></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 63pt; text-indent: -63pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 36pt"></TD><TD STYLE="width: 27pt">(b)</TD><TD><FONT STYLE="font-variant: small-caps">Address of Principal Business Office or, if None, Residence:</FONT></TD></TR></TABLE>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 63pt"><FONT STYLE="font-style: normal">&nbsp;</FONT></P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 63pt"><FONT STYLE="font-style: normal">192
Lytton Avenue, Palo Alto, CA 94301</FONT></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 63pt; text-indent: -63pt">&nbsp;</P>

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<TD STYLE="width: 36pt"></TD><TD STYLE="width: 27pt">(c)</TD><TD><FONT STYLE="font-variant: small-caps">Citizenship:</FONT></TD></TR></TABLE>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 63pt"><FONT STYLE="font-style: normal">&nbsp;</FONT></P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 63pt"><FONT STYLE="font-style: normal">Vivo
Capital IX, LLC is a Delaware limited liability company.</FONT></P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 63pt"><FONT STYLE="font-style: normal">&nbsp;</FONT></P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 63pt"><FONT STYLE="font-style: normal">Vivo
Opportunity, LLC is a Delaware limited liability company.</FONT></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 63pt; text-indent: -63pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 36pt"></TD><TD STYLE="width: 27pt">(d)</TD><TD><FONT STYLE="font-variant: small-caps">Title of Class of Securities:</FONT></TD></TR></TABLE>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 63pt"><FONT STYLE="font-style: normal">&nbsp;</FONT></P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 63pt"><FONT STYLE="font-style: normal">Common
Stock, without par value</FONT></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 63pt; text-indent: -63pt">&nbsp;</P>

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<TD STYLE="width: 36pt"></TD><TD STYLE="width: 27pt">(e)</TD><TD>CUSIP <FONT STYLE="font-variant: small-caps">Number:</FONT></TD></TR></TABLE>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 63pt"><FONT STYLE="font-style: normal">&nbsp;</FONT></P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 63pt"><FONT STYLE="font-style: normal">29668H104</FONT></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 45pt; text-indent: -45pt"><FONT STYLE="font-variant: small-caps">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0"></TD><TD STYLE="width: 63pt; text-align: left"><FONT STYLE="font-variant: small-caps">Item</FONT> 3.</TD><TD STYLE="text-align: left"><FONT STYLE="font-variant: small-caps">If This Statement
is Filed Pursuant to </FONT><FONT STYLE="background-color: white">&sect;&sect; 240.13d-1(b), <FONT STYLE="font-variant: small-caps">or
</FONT>240.13d-2(b) <FONT STYLE="font-variant: small-caps">or</FONT> (c)</FONT><FONT STYLE="font-variant: small-caps">, Check
Whether the Person Filing is a:</FONT></TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 85.5pt; text-indent: -49.5pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 88%; border-collapse: collapse; margin-left: 45pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 25pt; padding-right: -0.25in; text-indent: 0in">(a)</TD>
    <TD STYLE="width: 25pt; padding-right: -0.25in; text-indent: 0in">&#9744;</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">Broker or dealer registered under Section 15 of the Act.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&nbsp;</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&nbsp;</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">(b)</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&#9744;</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">Bank as defined in Section 3(a)(6) of the Act.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&nbsp;</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&nbsp;</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">(c)</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&#9744;&nbsp;</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">Insurance company as defined in Section 3(a)(19) of the Act.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&nbsp;</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&nbsp;</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">(d)</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&#9744;&nbsp;</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">Investment company registered under Section 8 of the Investment Company Act of 1940.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&nbsp;</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&nbsp;</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">(e)</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&#9744;&nbsp;</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">An investment adviser in accordance with <FONT STYLE="background-color: white">&sect; 240.13d-1(b)(1)(ii)(E)</FONT>;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&nbsp;</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&nbsp;</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">(f)</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&#9744;&nbsp;</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">An employee benefit plan or endowment fund in accordance with <FONT STYLE="background-color: white">&sect; 240.13d-1</FONT>(b)(1)(ii)(F);</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&nbsp;</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&nbsp;</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">(g)</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&#9744;&nbsp;</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">A parent holding company or control person in accordance with <FONT STYLE="background-color: white">&sect; 240.13d-1</FONT>(b)(l)(ii)(G);</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&nbsp;</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&nbsp;</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">(h)</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&#9744;&nbsp;</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">A savings association as defined in Section 3(b) of the Federal Deposit Insurance Act;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&nbsp;</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&nbsp;</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">(i)</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&#9744;&nbsp;</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">A church plan that is excluded from the definition of an investment company under Section 3(c)(14) of the Investment Company Act;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&nbsp;</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&nbsp;</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">(j)</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&#9744;&nbsp;</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">A non-U.S. institution in accordance with <FONT STYLE="background-color: white">&sect; 240.13d-1</FONT>(b)(1)(ii)(J);</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&nbsp;</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&nbsp;</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">(k)</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">&#9744;&nbsp;</TD>
    <TD STYLE="padding-right: -0.25in; text-indent: 0in">Group, in accordance with <FONT STYLE="background-color: white">&sect; 240.13d-1</FONT>(b)(l)(ii)(K).</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in">If filing as a non-U.S. institution
in accordance with <FONT STYLE="background-color: white">&sect; 240.13d-1</FONT>(b)(1(ii)(j), please specify the type of institution:
________________</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in">Not Applicable.</P>

<P STYLE="font: small-caps bold 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in 0pt 45pt; text-indent: -45pt">&nbsp;</P>

<P STYLE="font: small-caps bold 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in 0pt 45pt; text-indent: -45pt"></P>

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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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<P STYLE="font: small-caps bold 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in 0pt 45pt; text-indent: -45pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 63pt"><FONT STYLE="font-variant: small-caps">Item 4.</FONT></TD><TD STYLE="padding-right: 0.5in"><FONT STYLE="font-variant: small-caps">Ownership.</FONT></TD></TR></TABLE>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 40.5pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 63pt"></TD><TD STYLE="width: 30pt; text-align: left">(a)</TD><TD STYLE="text-align: justify"><FONT STYLE="font-variant: small-caps">Amount Beneficially
Owned:</FONT></TD>
</TR></TABLE>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in"><FONT STYLE="font-style: normal; font-weight: normal">&nbsp;</FONT></P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in"><FONT STYLE="font-style: normal; font-weight: normal">(1)
Vivo Capital IX, LLC</FONT></P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in"><FONT STYLE="font-style: normal; font-weight: normal">&nbsp;</FONT></P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in"><FONT STYLE="font-style: normal; font-weight: normal">The
314,739 shares of Common Stock are held of record by Vivo Capital Fund IX, L.P. Vivo Capital IX, LLC is the general partner of
Vivo Capital Fund IX, L.P. The voting members of Vivo Capital IX, LLC are Frank Kung, Edgar Engleman, Shan Fu, Jack Nielsen and
Michael Chang, none of whom has individual voting or investment power with respect to these shares and each of whom disclaims beneficial
ownership of such shares.</FONT></P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in"><FONT STYLE="font-style: normal; font-weight: normal">&nbsp;</FONT></P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in"><FONT STYLE="font-style: normal; font-weight: normal">(2)
Vivo Opportunity, LLC</FONT></P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in"><FONT STYLE="font-style: normal; font-weight: normal">&nbsp;</FONT></P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in"><FONT STYLE="font-style: normal; font-weight: normal">The
1,410,514 shares of Common Stock are held of record by Vivo Opportunity Fund, L.P. Vivo Opportunity, LLC is the general partner
of Vivo Opportunity Fund, L.P. The voting members of Vivo Opportunity, LLC are Albert Cha, Gaurav Aggarwal, Shan Fu, Frank Kung
and Michael Chang, none of whom has individual voting or investment power with respect to these shares and each of whom disclaims
beneficial ownership of such shares.</FONT></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 40.5pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 63pt"></TD><TD STYLE="width: 30pt; text-align: left">(b)</TD><TD STYLE="text-align: justify"><FONT STYLE="font-variant: small-caps">Percent of
class:</FONT></TD>
</TR></TABLE>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1.25in; text-indent: 0in"><FONT STYLE="font-style: normal; font-weight: normal">&nbsp;</FONT></P>

<P STYLE="text-indent: 93pt; font: italic 10pt Times New Roman, Times, Serif; text-align: left; margin-top: 0pt; margin-right: 0; margin-bottom: 0pt"><FONT STYLE="font-style: normal; font-weight: normal">Vivo
Capital IX, LLC: 1.0%</FONT></P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; text-indent: 93pt; text-align: left; margin-top: 0pt; margin-right: 0; margin-bottom: 0pt"><FONT STYLE="font-style: normal; font-weight: normal">&nbsp;</FONT></P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; text-indent: 93pt; text-align: left; margin-top: 0pt; margin-right: 0; margin-bottom: 0pt"><FONT STYLE="font-style: normal; font-weight: normal">Vivo
Opportunity, LLC: 4.4 %</FONT></P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1.25in; text-indent: 0in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 63pt"></TD><TD STYLE="width: 30pt; text-align: left">(c)</TD><TD STYLE="text-align: justify"><FONT STYLE="font-variant: small-caps">Number of shares
as to which such person has:</FONT></TD>
</TR></TABLE>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 89.7pt; text-indent: -22.2pt"><FONT STYLE="font-style: normal; font-weight: normal">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: italic 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 93pt"></TD><TD STYLE="width: 30pt"><FONT STYLE="font-style: normal; font-weight: normal">(i)</FONT></TD><TD><FONT STYLE="font-style: normal; font-weight: normal">Sole power to vote or to direct the vote:</FONT></TD></TR></TABLE>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; text-indent: 123pt; margin-top: 0pt; margin-right: 0; margin-bottom: 0pt; text-align: left"><FONT STYLE="font-style: normal; font-weight: normal">&nbsp;</FONT></P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; text-indent: 123pt; margin-top: 0pt; margin-right: 0; margin-bottom: 0pt; text-align: left"><FONT STYLE="font-style: normal; font-weight: normal">Vivo
Capital IX, LLC: 314,739 shares</FONT></P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; text-indent: 123pt; margin-top: 0pt; margin-right: 0; margin-bottom: 0pt; text-align: left"><FONT STYLE="font-style: normal; font-weight: normal">&nbsp;</FONT></P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; text-indent: 123pt; margin-top: 0pt; margin-right: 0; margin-bottom: 0pt; text-align: left"><FONT STYLE="font-style: normal; font-weight: normal">Vivo
Opportunity, LLC: 1,410,514 shares</FONT></P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; text-indent: 123pt; margin-top: 0pt; margin-right: 0; margin-bottom: 0pt; text-align: left"><FONT STYLE="font-style: normal; font-weight: normal">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: italic 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 93pt"></TD><TD STYLE="width: 30pt; text-align: left"><FONT STYLE="font-style: normal; font-weight: normal">(ii)</FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="font-style: normal; font-weight: normal">Shared
power to vote or to direct the vote: 0</FONT></TD>
</TR></TABLE>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1.25in; text-indent: -22.5pt"><FONT STYLE="font-style: normal; font-weight: normal">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: italic 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 93pt"></TD><TD STYLE="width: 30pt; text-align: left"><FONT STYLE="font-style: normal; font-weight: normal">(iii)</FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="font-style: normal; font-weight: normal">Sole
power to dispose or to direct the disposition of:</FONT></TD>
</TR></TABLE>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; text-indent: 123pt; margin-top: 0pt; margin-right: 0; margin-bottom: 0pt; text-align: left"><FONT STYLE="font-style: normal; font-weight: normal">&nbsp;</FONT></P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; text-indent: 123pt; margin-top: 0pt; margin-right: 0; margin-bottom: 0pt; text-align: left"><FONT STYLE="font-style: normal; font-weight: normal">Vivo
Capital IX, LLC: 314,739 shares</FONT></P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-right: 0; margin-bottom: 0pt; text-indent: 123pt"><FONT STYLE="font-style: normal; font-weight: normal">&nbsp;</FONT></P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; text-indent: 123pt; margin-top: 0pt; margin-right: 0; margin-bottom: 0pt; text-align: left"><FONT STYLE="font-style: normal; font-weight: normal">Vivo
Opportunity, LLC: 1,410,514 shares</FONT></P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; text-indent: 123pt; margin-top: 0pt; margin-right: 0; margin-bottom: 0pt; text-align: left"><FONT STYLE="font-style: normal; font-weight: normal">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: italic 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 93pt"></TD><TD STYLE="width: 30pt; text-align: left"><FONT STYLE="font-style: normal; font-weight: normal">(iv)</FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="font-style: normal; font-weight: normal">Shared
power to dispose of or to direct the disposition of: 0</FONT></TD>
</TR></TABLE>

<P STYLE="font: small-caps bold 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in 0pt 45pt; text-indent: -45pt">&nbsp;</P>

<P STYLE="font: small-caps bold 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in 0pt 45pt; text-indent: -45pt"></P>

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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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<P STYLE="font: small-caps bold 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in 0pt 45pt; text-indent: -45pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 63pt"><FONT STYLE="font-variant: small-caps">Item 5.</FONT></TD><TD STYLE="padding-right: 0.5in"><FONT STYLE="font-variant: small-caps">Ownership
                                         of Five Percent or Less of a Class.</FONT></TD></TR></TABLE>

<P STYLE="font: small-caps 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 63pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 63pt"><FONT STYLE="font-variant: normal; font-weight: normal">Not
Applicable.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 63pt"><FONT STYLE="font-variant: normal; font-weight: normal">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 63pt"><FONT STYLE="font-variant: small-caps">Item 6.</FONT></TD><TD STYLE="padding-right: 0.5in"><FONT STYLE="font-variant: small-caps">Ownership
                                         of More than Five Percent on Behalf of Another Person.</FONT></TD></TR></TABLE>

<P STYLE="font: small-caps 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in 0pt 45pt; text-indent: -45pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 63pt"><FONT STYLE="font-variant: normal; font-weight: normal">Not
Applicable.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 63pt"><FONT STYLE="font-variant: normal; font-weight: normal">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0"></TD><TD STYLE="width: 63pt; text-align: left"><FONT STYLE="font-variant: small-caps">Item 7.</FONT></TD><TD STYLE="text-align: left"><FONT STYLE="font-variant: small-caps">Identification
                                         and Classification of the Subsidiary Which Acquired the Security Being Reported on by
                                         the Parent Holding Company or Control Person.</FONT></TD>
</TR></TABLE>

<P STYLE="font: small-caps 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in 0pt 45pt; text-indent: -45pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 63pt"><FONT STYLE="font-variant: normal; font-weight: normal">Not
Applicable.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 63pt"><FONT STYLE="font-variant: normal; font-weight: normal">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 63pt"><FONT STYLE="font-variant: small-caps">Item 8.</FONT></TD><TD STYLE="padding-right: 0.5in"><FONT STYLE="font-variant: small-caps">Identification
                                         and Classification of Members of the Group.</FONT></TD></TR></TABLE>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 45pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 63pt"><FONT STYLE="font-style: normal; font-weight: normal">Not
applicable.</FONT></P>

<P STYLE="font: small-caps bold 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in 0pt 45pt; text-indent: -45pt">&nbsp;</P>

<P STYLE="font: small-caps bold 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in 0pt 45pt; text-indent: -45pt"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 63pt"><FONT STYLE="font-variant: small-caps">Item 9.</FONT></TD><TD STYLE="padding-right: 0.5in"><FONT STYLE="font-variant: small-caps">Notice
                                         of Dissolution of Group.</FONT></TD></TR></TABLE>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 45pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 63pt"><FONT STYLE="font-style: normal; font-weight: normal">Not
applicable.</FONT></P>

<P STYLE="font: small-caps bold 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in 0pt 45pt; text-indent: -45pt">&nbsp;</P>

<P STYLE="font: small-caps bold 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in 0pt 45pt; text-indent: -45pt"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 63pt"><FONT STYLE="font-variant: small-caps">Item 10.</FONT></TD><TD STYLE="padding-right: 0.5in"><FONT STYLE="font-variant: small-caps">Certifications.</FONT></TD></TR></TABLE>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><FONT STYLE="font-style: normal">&nbsp;</FONT></P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 63pt"><FONT STYLE="font-style: normal">By
signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are
not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were
not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than
activities solely in connection with a nomination under &sect;240.14a11.</FONT></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in 0pt 45pt; text-align: center">&nbsp;</P>


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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">SIGNATURE</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 45.35pt">After reasonable
inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete
and correct.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 45.35pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 60%">&nbsp;</TD>
    <TD STYLE="width: 40%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Vivo Capital IX, LLC</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">November 6, 2020</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(Date)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/ Frank Kung</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(Signature)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Managing Member</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(Title)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Vivo Opportunity, LLC</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">November 6, 2020</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(Date)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/ Albert Cha</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(Signature)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Managing Member</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(Title)</FONT></TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; background-color: white">&nbsp;</P>


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<P STYLE="text-align: center; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right; margin-top: 0pt; margin-bottom: 0pt"><B><A NAME="a_001"></A>Exhibit 99.1</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; background-color: white"><B>JOINT
FILING AGREEMENT</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0pt; margin-bottom: 0pt; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left;">In accordance
with Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, the persons named below agree to the joint filing on
behalf of each of them of a statement on Schedule 13G (including amendments thereto) with respect to the Common Stock, without
par value of ESSA Pharma Inc., and further agree that this Joint Filing Agreement be included as an Exhibit to such joint filing.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 60%">&nbsp;</TD>
    <TD STYLE="width: 40%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Vivo Capital IX, LLC</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">November 6, 2020</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(Date)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/ Frank Kung</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(Signature)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Managing Member</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(Title)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Vivo Opportunity, LLC</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">November 6, 2020</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(Date)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/ Albert Cha</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(Signature)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Managing Member</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(Title)</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="text-align: center; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">8</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in"></P>

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