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STOCKHOLDERS’ EQUITY (Tables) | 12 Months Ended
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Dec. 31, 2022
Accumulated Other Comprehensive Income (Loss) [Line Items] |
SCHEDULE OF RESERVED SHARES | SCHEDULE OF RESERVED SHARES
Exercise of issued and future grants of stock options |  |  | 608,012 |
Exercise of stock warrants |  |  | 4,575,617 |
Total |  |  | 5,183,629 |
SCHEDULE OF STOCK OPTION ACTIVITY | The following represents a summary of the options granted to employees and non-employee service providers that were outstanding at December 31, 2022, and changes during the twelve months then ended: SCHEDULE OF STOCK OPTION ACTIVITY
|  | Shares |  |  | Weighted– Average Exercise Price |  |  | Range of Exercise Price |  |  | Weighted– Average Remaining Life (Years) |
Total outstanding – December 31, 2021 |  |  | 484,186 |  |  | $ | 60.70 |  |  |  | $12.40 — $14,657.50 |  |  |  | 8.52 |
Granted |  |  | 134,469 |  |  |  | 5.24 |  |  |  | 5.14 — 10.50 |  |  |  | 5.99 |
Expired |  |  | (9,379 | ) |  |  | 932.75 |  |  |  | 57.50 - 14,657.50 |  |  |  | — |
Forfeited |  |  | (1,264 | ) |  |  | 22.64 |  |  |  | 5.14 - 49.70 |  |  |  | — |
Total outstanding – December 31, 2022 |  |  | 608,012 |  |  | $ | 35.02 |  |  |  | $5.14 — $51.30 |  |  |  | 8.09 |
Exercisable (vested) |  |  | 288,704 |  |  | $ | 46.32 |  |  |  | $12.40 — $51.30 |  |  |  | 7.59 |
Non-Exercisable (non-vested) |  |  | 319,308 |  |  | $ | 24.80 |  |  |  | $5.14 — $10.50 |  |  |  | 8.59 |
SCHEDULE OF ASSUMPTION USED IN BLACK-SCHOLES OPTION-PRICING METHOD | The material factors incorporated in the Black-Scholes model in estimating the fair value of the options granted for the periods presented were as follows: SCHEDULE OF ASSUMPTION USED IN BLACK-SCHOLES OPTION-PRICING METHOD
|  | For the Years Ended December 31, |
|  | 2022 |  |  | 2021 |
Expected dividend yield |  |  | 0.00 | % |  |  | 0.00 | %
Expected stock-price volatility |  |  | 103 | % |  |  | 102 | %
Risk-free interest rate |  |  | 1.58% — 3.77% |  |  |  | 0.84% — 1.51% |
Expected average term of options (in years) |  |  | 5.99 |  |  |  | 6.27 |
Stock price |  |  | 5.14 - 10.50 |  |  |  | 12.40 — 32.90 |
SCHEDULE OF SHARE-BASED COMPENSATION EXPENSE | The Company recorded stock-based compensation expense and classified it in the Consolidated Statements of Operations as follows: SCHEDULE OF SHARE-BASED COMPENSATION EXPENSE
|  | 2022 |  |  | 2021 |
|  | For the Years Ended December 31, |
|  | 2022 |  |  | 2021 |
General and administrative |  | $ | 4,649,649 |  |  | $ | 4,465,911 |
Research and development |  |  | 834,395 |  |  |  | 827,740 |
Total |  | $ | 5,484,044 |  |  | $ | 5,293,651 |
Compensatory Warrant Activity [Member] |
Accumulated Other Comprehensive Income (Loss) [Line Items] |
SCHEDULE OF WARRANT ACTIVITY | The following table summarizes the equity classified compensatory warrant activity for the year ended December 31, 2022: SCHEDULE OF WARRANT ACTIVITY
|  | Common Stock |
|  | Shares |  |  | Weighted– Average Exercise Price |  |  | Range of Exercise Price |  |  | Weighted– Average Remaining Life (Years) |
Total outstanding – December 31, 2021 |  |  | 179,046 |  |  | $ | 15.20 |  |  | $ | 11.10 — $25.40 |  |  |  | 2.64 |
Granted to advisor and its designees |  |  | — |  |  |  | — |  |  |  |  |  |  |  |  |
Exercised |  |  | — |  |  |  | — |  |  |  |  |  |  |  |  |
Expired |  |  | — |  |  |  | — |  |  |  |  |  |  |  |  |
Forfeited |  |  | — |  |  |  | — |  |  |  |  |  |  |  |  |
Total outstanding – December 31, 2022 |  |  | 179,046 |  |  | $ | 9.12 |  |  | $ | 1.32 — $25.40 |  |  |  | 1.73 |
Exercisable |  |  | 179,046 |  |  | $ | 9.12 |  |  | $ | 1.32- $25.40 |  |  |  | 1.73 |
Non-Exercisable |  |  | — |  |  | $ | — |  |  | $ | — |  |  |  | — |
The following table summarizes the equity classified compensatory warrant activity for the year ended December 31, 2021:
|  | Common Stock |
|  | Shares |  |  | Weighted– Average Exercise Price |  |  | Range of Exercise Price |  |  | Weighted– Average Remaining Life (Years) |
Total outstanding – December 31, 2020 |  |  | 129,403 |  |  | $ | 16.60 |  |  |  |  |  |  |  |  |
Granted to advisor and its designees |  |  | 60,000 |  |  |  | 13.20 |  |  |  |  |  |  |  |  |
Exercised |  |  | (3,839 | ) |  |  | 20.90 |  |  |  |  |  |  |  |  |
Expired |  |  | — |  |  |  | — |  |  |  |  |  |  |  |  |
Forfeited |  |  | (6,518 | ) |  |  | 20.70 |  |  |  |  |  |  |  |  |
Total outstanding – December 31, 2021 |  |  | 179,046 |  |  | $ | 15.20 |  |  |  | $11.10 — $25.40 |  |  |  | 2.64 |
Exercisable |  |  | 179,046 |  |  | $ | 15.20 |  |  |  | $11.10 — $25.40 |  |  |  | 2.64 |
Non-Exercisable |  |  | — |  |  | $ | — |  |  | $ | — |  |  |  | — |
Non Compensatory Warrant Activity [Member] |
Accumulated Other Comprehensive Income (Loss) [Line Items] |
SCHEDULE OF WARRANT ACTIVITY | The following table summarizes the noncompensatory equity classified warrant activity for the year ended December 31, 2022: SCHEDULE OF WARRANT ACTIVITY
|  | Common Stock |
|  | Shares |  |  | Weighted– Average Exercise Price |  |  | Range of Exercise Price |  |  | Weighted– Average Remaining Life (Years) |
Total outstanding – December 31, 2021 |  |  | 554,914 |  |  | $ | 20.10 |  |  |  | 11.10— 37.78 |  |  |  | 1.32 |
Granted |  |  | 331,464 |  |  |  | 0.01 |  |  |  | 0.01 |  |  |  |  |
Exercised |  |  | (331,464 | ) |  |  | 0.01 |  |  |  | 0.01 |  |  |  |  |
Expired |  |  | (7,911 | ) |  |  | 37.78 |  |  |  | 37.78 |  |  |  |  |
Forfeited |  |  | — |  |  |  | — |  |  |  | — |  |  |  |  |
Total outstanding – December 31, 2022 |  |  | 547,003 |  |  |  | 19.76 |  |  |  | 1.32 - 20.00 |  |  |  | 0.33 |
Exercisable |  |  | 547,003 |  |  |  | 19.76 |  |  |  | 1.32 - 20.00 |  |  |  | 0.33 |
Non-Exercisable |  |  | — |  |  | $ | — |  |  | $ | — |  |  |  | — |
The following table summarizes the noncompensatory equity classified warrant activity for the year ended December 31, 2021:
|  | Common Stock |
|  | Shares |  |  | Weighted– Average Exercise Price |  |  | Range of Exercise Price |  |  | Weighted– Average Remaining Life (Years) |
Total outstanding – December 31, 2020 |  |  | 654,978 |  |  | $ | 43.60 |  |  |  |  |  |  |  |  |
Granted |  |  | — |  |  |  | — |  |  |  |  |  |  |  |  |
Exercised |  |  | (100,000 | ) |  |  | 0.01 |  |  |  |  |  |  |  |  |
Expired |  |  | (64 | ) |  |  | 23,250.00 |  |  |  |  |  |  |  |  |
Forfeited |  |  | — |  |  |  | — |  |  |  |  |  |  |  |  |
Total outstanding – December 31, 2021 |  |  | 554,914 |  |  |  | 20.10 |  |  |  |  |  |  |  |  |
Exercisable |  |  | 554,914 |  |  |  | 20.10 |  |  |  | 11.10— 37.78 |  |  |  | 1.32 |
Non-Exercisable |  |  | — |  |  | $ | — |  |  | $ | — |  |  |  | — |

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