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STOCKHOLDERS’ EQUITY (Tables)
 12 Months Ended
Dec. 31, 2022
Accumulated Other Comprehensive Income (Loss) [Line Items]  
SCHEDULE OF RESERVED SHARES

 

      
Exercise of issued and future grants of stock options   608,012 
Exercise of stock warrants   4,575,617 
Total   5,183,629 
SCHEDULE OF STOCK OPTION ACTIVITY

The following represents a summary of the options granted to employees and non-employee service providers that were outstanding at December 31, 2022, and changes during the twelve months then ended:

 

   Shares   Weighted–
Average
Exercise
Price		   Range of
Exercise
Price		   Weighted–
Average
Remaining
Life (Years)		 
Total outstanding – December 31, 2021   484,186   $60.70    $12.40 — $14,657.50    8.52 
Granted   134,469    5.24    5.14 — 10.50    5.99 
Expired   (9,379)   932.75    57.50 - 14,657.50    — 
Forfeited   (1,264)   22.64    5.14 - 49.70    — 
Total outstanding – December 31, 2022   608,012   $35.02    $5.14 — $51.30    8.09 
Exercisable (vested)   288,704   $46.32    $12.40 — $51.30    7.59 
Non-Exercisable (non-vested)   319,308   $24.80    $5.14 — $10.50    8.59 
SCHEDULE OF ASSUMPTION USED IN BLACK-SCHOLES OPTION-PRICING METHOD

The material factors incorporated in the Black-Scholes model in estimating the fair value of the options granted for the periods presented were as follows:

 

   For the Years Ended
December 31,		 
   2022   2021 
Expected dividend yield   0.00%   0.00%
Expected stock-price volatility   103%   102%
Risk-free interest rate   1.58% — 3.77%    0.84% — 1.51% 
Expected average term of options (in years)   5.99    6.27 
Stock price   5.14 - 10.50    12.40 — 32.90 
SCHEDULE OF SHARE-BASED COMPENSATION EXPENSE

The Company recorded stock-based compensation expense and classified it in the Consolidated Statements of Operations as follows:

 

   2022   2021 
   For the Years Ended
December 31,		 
   2022   2021 
General and administrative  $4,649,649   $4,465,911 
Research and development   834,395    827,740 
Total  $5,484,044   $5,293,651 
Compensatory Warrant Activity [Member]  
Accumulated Other Comprehensive Income (Loss) [Line Items]  
SCHEDULE OF WARRANT ACTIVITY

The following table summarizes the equity classified compensatory warrant activity for the year ended December 31, 2022:

 

   Common Stock 
   Shares   Weighted– Average
Exercise
Price		   Range of
Exercise Price		   Weighted–
Average
Remaining
Life (Years)		 
Total outstanding – December 31, 2021   179,046   $15.20   $11.10 — $25.40    2.64 
Granted to advisor and its designees   —    —           
Exercised   —    —           
Expired   —    —           
Forfeited   —    —           
Total outstanding – December 31, 2022   179,046   $9.12   $1.32 — $25.40    1.73 
Exercisable   179,046   $9.12   $1.32- $25.40    1.73 
Non-Exercisable   —   $—   $—    — 

 

The following table summarizes the equity classified compensatory warrant activity for the year ended December 31, 2021:

 

   Common Stock 
   Shares   Weighted– Average
Exercise
Price		   Range of
Exercise Price		   Weighted–
Average
Remaining
Life (Years)		 
Total outstanding – December 31, 2020   129,403   $16.60           
Granted to advisor and its designees   60,000    13.20           
Exercised   (3,839)   20.90           
Expired   —    —           
Forfeited   (6,518)   20.70           
Total outstanding – December 31, 2021   179,046   $15.20    $11.10 — $25.40    2.64 
Exercisable   179,046   $15.20    $11.10 — $25.40    2.64 
Non-Exercisable   —   $—   $—    — 
Non Compensatory Warrant Activity [Member]  
Accumulated Other Comprehensive Income (Loss) [Line Items]  
SCHEDULE OF WARRANT ACTIVITY

The following table summarizes the noncompensatory equity classified warrant activity for the year ended December 31, 2022:

 

   Common Stock 
   Shares   Weighted–
Average
Exercise
Price		   Range of
Exercise Price		   Weighted–
Average
Remaining
Life (Years)		 
Total outstanding – December 31, 2021   554,914   $20.10    11.10— 37.78    1.32 
Granted   331,464    0.01    0.01      
Exercised   (331,464)   0.01    0.01      
Expired   (7,911)   37.78    37.78      
Forfeited   —    —    —      
Total outstanding – December 31, 2022   547,003    19.76    1.32 - 20.00    

0.33

 
Exercisable   547,003   19.76    1.32 - 20.00    0.33 
Non-Exercisable   

—

   $

—

   $

—

    

—

 

 

The following table summarizes the noncompensatory equity classified warrant activity for the year ended December 31, 2021:

 

   Common Stock 
   Shares   Weighted–
Average
Exercise
Price		   Range of
Exercise Price		   Weighted–
Average
Remaining
Life (Years)		 
Total outstanding – December 31, 2020   654,978   $43.60           
Granted   —    —           
Exercised   (100,000)   0.01           
Expired   (64)   23,250.00           
Forfeited   —    —           
Total outstanding – December 31, 2021   554,914    20.10           
Exercisable   554,914    20.10    11.10— 37.78    1.32 
Non-Exercisable   —   $—   $—    —