XML 72 R63.htm IDEA: XBRL DOCUMENT v3.23.1
RESEARCH AND LICENSE AGREEMENTS (Details Narrative) - USD ($)
1 Months Ended 3 Months Ended 28 Months Ended
Dec. 31, 2022
Oct. 31, 2022
Mar. 31, 2022
Jan. 31, 2022
Nov. 30, 2021
Feb. 28, 2021
Mar. 31, 2019
Jun. 30, 2018
Mar. 31, 2023
Mar. 31, 2022
Sep. 30, 2020
Dec. 31, 2021
Jun. 30, 2020
Research and development expense                 $ 2,121,551 $ 1,864,745      
License cost                 14,000 2,000      
Proceeds from convertible debt $ 3,000,000.0                        
Revenue from contract with customer excluding assessed tax                 1,607,170 722,029      
Yi Xin Zhen Duan Jishu Ltd [Member]                          
Deferred revenue                       $ 670,000  
Prediction Biosciences SAS [Member] | Product [Member]                          
Revenue from contract with customer excluding assessed tax                 86,000 0      
Sponsored Research and License Agreement [Member]                          
Research and development expense                 0 87,000      
License cost                 21,000 55,000      
Sponsored Research and License Agreement [Member] | University of Louisville Research Foundation [Member]                          
Reimbursement of research expenses   $ 2,700,000 $ 2,700,000     $ 2,700,000 $ 693,000            
Agreement term payment, description             In July 2020, the Company entered into an exclusive license agreement with ULRF for RAS interaction inhibitor drug candidates. Under the agreement, the Company will take over development, regulatory approval and commercialization of the candidates from ULRF and is responsible for maintenance of the related intellectual property portfolio. In return, the Company paid ULRF approximately $112,000 for an upfront license fee and reimbursement of prior patent costs. In addition, the Company has agreed to pay ULRF (i) royalties, on patent-covered net sales associated with the commercialization, of 4% (on net sales up to a cumulative $250,000,000) or 5% (on net sales above a cumulative $250,000,000), until expiration of the licensed patent, and 2.5% (on net sales for any sales not covered by Licensed Patents), (ii) 30% to 50% of any non-royalty sublicensee income received (50% for sublicenses granted in the first two years of the ULRF license agreement, 40% for sublicenses granted in the third or fourth years of the ULRF license agreement, and 30% for sublicenses granted in the fifth year of the ULRF license agreement or thereafter), (iii) reimbursements for ongoing costs associated with the preparation, filing, prosecution and maintenance of licensed patents, incurred prior to July 2020, and (iv) payments ranging from            
Regulatory marketing approval, expenses             $ 300,000            
Cumulative sales               $ 500,000,000          
Revenue             500,000,000            
License and Sponsored Research Agreements [Member] | University of Louisville Research Foundation [Member]                          
Reimbursement of research expenses                     $ 830,000    
Agreement term payment, description                     Under the license agreement, the Company agreed to pay ULRF (i) royalties, on patent-covered net sales associated with the commercialization of anti-nucleolin agent-conjugated nanoparticles, of 4% (on net sales up to a cumulative $250,000,000) or 5% (on net sales above a cumulative $250,000,000), until expiration of the last to expire of the licensed patents, (ii) 30% to 50% of any non-royalty sublicensee income received (50% for sublicenses granted in the first two years of the ULRF license agreement, 40% for sublicenses granted in the third or fourth years of the ULRF license agreement, and 30% for sublicenses granted in the fifth year of the ULRF license agreement or thereafter), (iii) reimbursements for ongoing costs associated with the preparation, filing, prosecution and maintenance of licensed patents, incurred prior to June 2018, and (iv) payments ranging from $100,000 to $5,000,000 upon the achievement of certain regulatory and commercial milestones    
Research and development expense                 223,000 184,000      
Proceeds from convertible debt                     $ 50,000    
Patent costs                     200,000    
License and Sponsored Research Agreements [Member] | University of Louisville Research Foundation [Member] | Licensed Product Sales [Member]                          
Regulatory marketing approval, expenses               5,000,000          
Cumulative sales             5,000,000            
Regulatory marketing approval, expenses               500,000          
License and Sponsored Research Agreements [Member] | University of Louisville Research Foundation [Member] | Phase 1 Clinical Trial [Member]                          
Milestone payment             50,000 100,000          
License and Sponsored Research Agreements [Member] | University of Louisville Research Foundation [Member] | Phase 2 Clinical Trial [Member]                          
Milestone payment             100,000 200,000          
License and Sponsored Research Agreements [Member] | University of Louisville Research Foundation [Member] | Phase 3 Clinical Trial [Member]                          
Milestone payment             150,000 350,000          
License and Sponsored Research Agreements [Member] | University of Louisville Research Foundation [Member] | Phase Clinical Trial [Member]                          
Milestone payment               500,000          
License and Sponsored Research Agreements [Member] | University of Louisville Research Foundation [Member] | Minimum [Member]                          
Milestone payment             50,000 100,000          
Shortfall payments                     10,000    
License and Sponsored Research Agreements [Member] | University of Louisville Research Foundation [Member] | Maximum [Member]                          
Milestone payment             5,000,000 $ 5,000,000          
Shortfall payments                     $ 50,000    
License Agreement [Member]                          
License cost                 $ 5,000 $ 310,000      
Reimbursement of patent       $ 160,000                  
License Agreement [Member] | Upfront Payment [Member]                          
Reimbursement of patent       $ 150,000                  
License Agreement [Member] | University of Louisville Research Foundation [Member]                          
Upfront license fee                         $ 24,000
License Agreement [Member] | University of Louisville Research Foundation [Member] | Minimum [Member]                          
Upfront license fee             20,000            
License Agreement [Member] | University of Louisville Research Foundation [Member] | Maximum [Member]                          
Upfront license fee             $ 100,000            
Research and development expense         $ 430,000