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RESEARCH AND LICENSE AGREEMENTS (Details Narrative) - USD ($) | 1 Months Ended | 12 Months Ended | 47 Months Ended
--- | --- | --- | ---
Jul. 31, 2023 | Dec. 31, 2022 | Jan. 31, 2022 | Nov. 30, 2020 | Jul. 31, 2020 | Jun. 30, 2020 | Mar. 31, 2019 | Dec. 31, 2023 | Dec. 31, 2022 | Apr. 30, 2022
Research and development expense |  |  |  |  |  |  |  | $ 5,209,250 | $ 4,486,120 |
Proceeds from convertible debt |  | $ 3,000,000.0 |  |  |  |  |  |  |  |
License Agreement [Member] |  |  |  |  |  |  |  |  |  |
Reimbursement of patent |  |  | $ 160,000 |  |  |  |  |  |  |
License costs |  |  |  |  |  |  |  | 128,000 | 338,000 |
License Agreement [Member] | University of Louisville Research Foundation [Member] |  |  |  |  |  |  |  |  |  |
Upfront license fee |  |  |  |  |  | $ 24,000 |  |  |  |
License Agreement [Member] | University of Louisville Research Foundation [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |
Research and development expense |  |  |  | $ 430,000 |  | $ 250,000 |  |  |  |
Master Laboratory Services Agreement [Member] | MLM Medical Labs [Member] |  |  |  |  |  |  |  |  |  |
Research and development expense | $ 7,600,000 |  |  |  |  |  |  |  |  |
Sponsored Research and License Agreement [Member] |  |  |  |  |  |  |  |  |  |
License costs |  |  |  |  |  |  |  | 23,000 | 94,000 |
Research and development expense |  |  |  |  |  |  |  | 0 | 164,000 |
Sponsored Research and License Agreement [Member] | University of Louisville Research Foundation [Member] |  |  |  |  |  |  |  |  |  |
Reimbursement of research expenses |  |  |  |  |  |  | $ 693,000 | 2,900,000 |  |
Agreement term payment, description |  |  |  |  | In July 2020, the Company entered into an exclusive license agreement with ULRF for RAS interaction inhibitor drug candidates. Under the agreement, the Company took over development, regulatory approval and commercialization of the candidates from ULRF and is responsible for maintenance of the related intellectual property portfolio. In return, ULRF received approximately $112,000 for an upfront license fee and reimbursement of prior patent costs. In addition, the Company has agreed to pay ULRF (i) royalties, on patent-covered net sales associated with the commercialization, of 4% (on net sales up to a cumulative $250,000,000) or 5% (on net sales above a cumulative $250,000,000), until expiration of the licensed patent, and 2.5% (on net sales for any sales not covered by Licensed Patents), (ii) 30% to 50% of any non-royalty sublicensee income received (50% for sublicenses granted in the first two years of the ULRF license agreement, 40% for sublicenses granted in the third or fourth years of the ULRF license agreement, and 30% for sublicenses granted in the fifth year of the ULRF license agreement or thereafter), (iii) reimbursements for ongoing costs associated with the preparation, filing, prosecution and maintenance of licensed patents, incurred prior to July 2020, and (iv) payments ranging from $50,000 to $5,000,000 upon the achievement of certain regulatory and commercial milestones. |  |  |  |  |
Marketing approval expenses |  |  |  |  | $ 300,000 |  |  |  |  |
Revenue |  |  |  |  | 500,000,000 |  |  |  |  | $ 500,000,000
Sponsored Research and License Agreement [Member] | University of Louisville Research Foundation [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |
Upfront license fee |  |  |  |  | 20,000 |  |  |  |  |
Sponsored Research and License Agreement [Member] | University of Louisville Research Foundation [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |
Upfront license fee |  |  |  |  | 100,000 |  |  |  |  |
License and Sponsored Research Agreements [Member] | University of Louisville Research Foundation [Member] |  |  |  |  |  |  |  |  |  |
Reimbursement of research expenses |  |  |  |  |  |  |  |  |  | $ 805,000
Agreement term payment, description |  |  |  |  |  |  |  |  |  | In addition, the Company agreed to pay ULRF (i) royalties, on patent-covered net sales associated with the commercialization of anti-nucleolin agent-conjugated nanoparticles, of 4% (on net sales up to a cumulative $250,000,000) or 5% (on net sales above a cumulative $250,000,000), until expiration of the last to expire of the licensed patents, (ii) 30% to 50% of any non-royalty sublicensee income received (50% for sublicenses granted in the first two years of the ULRF license agreement, 40% for sublicenses granted in the third or fourth years of the ULRF license agreement, and 30% for sublicenses granted in the fifth year of the ULRF license agreement or thereafter), (iii) reimbursements for ongoing costs associated with the preparation, filing, prosecution and maintenance of licensed patents, incurred prior to June 2018, and (iv) payments ranging from $100,000 to $5,000,000 upon the achievement of certain regulatory and commercial milestones.
Marketing approval expenses |  |  |  |  |  |  |  |  |  | $ 500,000
Proceeds from convertible debt |  |  |  |  |  |  |  |  |  | 50,000
Patent costs |  |  |  |  |  |  |  |  |  | 200,000
License and Sponsored Research Agreements [Member] | University of Louisville Research Foundation [Member] | Licensed Product Sales [Member] |  |  |  |  |  |  |  |  |  |
Cumulative sales |  |  |  |  | 5,000,000 |  |  |  |  | 5,000,000
Regulatory marketing approval, expenses |  |  |  |  |  |  |  |  |  | 500,000
License and Sponsored Research Agreements [Member] | University of Louisville Research Foundation [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |
Milestone payment |  |  |  |  | 50,000 |  |  |  |  | 100,000
Shortfall payments |  |  |  |  |  |  |  |  |  | 10,000
License and Sponsored Research Agreements [Member] | University of Louisville Research Foundation [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |
Milestone payment |  |  |  |  | 5,000,000 |  |  |  |  | 5,000,000
Shortfall payments |  |  |  |  |  |  |  |  |  | 50,000
Sponsored Research Agreements And License [Member] |  |  |  |  |  |  |  |  |  |
License costs |  |  |  |  |  |  |  | 133,000 | 40,000 |
Research and development expense |  |  |  |  |  |  |  | $ 743,000 | $ 758,000 |
Upfront Payment [Member] | License Agreement [Member] |  |  |  |  |  |  |  |  |  |
Reimbursement of patent |  |  | $ 150,000 |  |  |  |  |  |  |
Phase 1 Clinical Trial [Member] | License and Sponsored Research Agreements [Member] | University of Louisville Research Foundation [Member] |  |  |  |  |  |  |  |  |  |
Milestone payment |  |  |  |  | 50,000 |  |  |  |  | 100,000
Phase 2 Clinical Trial [Member] | License and Sponsored Research Agreements [Member] | University of Louisville Research Foundation [Member] |  |  |  |  |  |  |  |  |  |
Milestone payment |  |  |  |  | 100,000 |  |  |  |  | 200,000
Phase 3 Clinical Trial [Member] | License and Sponsored Research Agreements [Member] | University of Louisville Research Foundation [Member] |  |  |  |  |  |  |  |  |  |
Milestone payment |  |  |  |  | $ 150,000 |  |  |  |  | $ 350,000

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