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v3.25.3

Roll-forward of TOI Activity (Details) - USD ($) | 1 Months Ended | 3 Months Ended | 9 Months Ended | 12 Months Ended
--- | --- | --- | --- | ---
Feb. 28, 2025 | Sep. 30, 2025 | Jun. 30, 2025 | Mar. 31, 2025 | Dec. 31, 2024 | Sep. 30, 2024 | Jun. 30, 2024 | Mar. 31, 2024 | Sep. 30, 2025 | Sep. 30, 2024 | Dec. 31, 2024
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |
R&D Expenses Incurred |  | $ 2,729,891 |  |  |  | $ 2,184,991 |  |  | $ 7,852,267 | $ 5,917,868 |
TOI Collaboration Agreement |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |
Amount Billed/ Submitted for Reimbursement |  | 1,467,935 | $ 1,168,022 | $ 1,727,386 | $ 601,197 | 1,783,472 | $ 1,341,297 | $ 189,904 |  |  | $ 3,915,870
Amount Reimbursed/ Received |  | (1,422,731) | (1,337,604) | (990,979) | (1,783,472) | (1,341,297) | (189,904) | 0 |  |  | (3,314,673)
R&D Expenses Incurred |  | 1,657,091 | 1,682,980 | 1,969,270 | 739,557 | 868,198 | 1,139,761 | 189,904 |  |  | 2,937,420
Collaboration Credits |  | (1,658,248) | (1,685,917) | (1,966,123) | (745,052) | (867,760) | (1,141,985) | (190,553) |  |  | (2,945,350)
Variance (foreign exchange timing) |  | (1,117) | (2,937) | 3,147 | (5,495) | 437 | (2,223) | (649) |  |  | (7,930)
Adjustment to Deferred Collaboration Credits |  | 10,015 | 163,277 | 251,304 | 92,546 | (788,934) | (450,056) | 0 | 424,596 | (1,238,990) | (1,146,444)
Adjustment to Accrued Expenses |  | $ 179,141 | $ 351,681 | (9,420) | 45,814 | $ (126,340) | $ 248,520 | $ 0 | $ 521,402 | $ 122,180 | $ 167,994
Phase 3 |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |
Amount Billed/ Submitted for Reimbursement | $ 389,782 |  |  | $ 1,337,604 |  |  |  |  |  |  |
Q4 2024 Collaboration Receivable |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |
Amount Reimbursed/ Received |  |  |  |  | $ (601,197) |  |  |  |  |  |

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