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Liquidity and Capital Resources (Details)
 12 Months Ended
Dec. 02, 2022
USD ($)
Nov. 23, 2022
$ / shares
shares
Jul. 12, 2022
USD ($)
$ / shares
Mar. 06, 2022
USD ($)
$ / shares
shares
Dec. 31, 2022
USD ($)
$ / shares
Dec. 31, 2021
USD ($)
$ / shares
Oct. 18, 2022
USD ($)
ft²
Liquidity and Capital Resources [Abstract]              
Cash         $ 11,446,000 $ 16,985,000  
Accumulated deficit         (165,297,000) (140,702,000)  
Net loss         (24,579,000) (122,545,000)  
Net cash used in operating activities         $ (20,976,000) $ (23,488,000)  
Common stock, par value (in dollars per share) | $ / shares         $ 0.005 $ 0.005  
Aggregate gross purchase price         $ 12,000,000    
New Facility Lease [Abstract]              
Area of office and laboratory space | ft²             45,500
Letter of credit             $ 4,100,000
Restricted cash         $ 4,100,000   $ 4,100,000
Common Warrants [Member]              
Liquidity and Capital Resources [Abstract]              
Warrant exercise price (in dollars per share) | $ / shares       $ 38.2      
Warrant exercisable term         6 months    
Warrant expiration term         5 years 6 months    
Pre-funded Warrants [Member]              
Liquidity and Capital Resources [Abstract]              
Warrant exercise price (in dollars per share) | $ / shares   $ 0.125          
PIPE Investor [Member]              
Liquidity and Capital Resources [Abstract]              
Private placement (in shares) | shares   2,185,000   343,000      
Common stock, par value (in dollars per share) | $ / shares       $ 0.005      
Number of common stock (in shares) | shares       1      
Unit price (in dollars per share) | $ / shares   $ 3.53          
Warrant exercise price (in dollars per share) | $ / shares       $ 0.1      
Aggregate gross purchase price       $ 12,000,000      
Proceeds from issuance of warrants to purchase of common stock $ 7,700,000            
Warrant exercisable term       6 months      
Warrant expiration term       5 years 6 months      
PIPE Investor [Member] | Common Warrants [Member]              
Liquidity and Capital Resources [Abstract]              
Private placement (in shares) | shares       343,000      
Number of common stock (in shares) | shares   1   1      
Warrant exercise price (in dollars per share) | $ / shares   $ 3.28          
Aggregate gross purchase price       $ 12,000,000      
Warrant exercisable term         6 months    
Warrant expiration term         5 years 6 months    
PIPE Investor [Member] | Pre-funded Warrants [Member]              
Liquidity and Capital Resources [Abstract]              
Private placement (in shares) | shares       68,000      
Number of common stock (in shares) | shares   2   1      
Warrant exercise price (in dollars per share) | $ / shares     $ 0.1        
Proceeds from issuance of warrants to purchase of common stock     $ 7,000