<SEC-DOCUMENT>0001104659-24-126354.txt : 20241206
<SEC-HEADER>0001104659-24-126354.hdr.sgml : 20241206
<ACCEPTANCE-DATETIME>20241206170510
ACCESSION NUMBER:		0001104659-24-126354
CONFORMED SUBMISSION TYPE:	S-1
PUBLIC DOCUMENT COUNT:		8
FILED AS OF DATE:		20241206
DATE AS OF CHANGE:		20241206

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Transcode Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001829635
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				811065054
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-1
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-283668
		FILM NUMBER:		241533095

	BUSINESS ADDRESS:	
		STREET 1:		6 LIBERTY SQUARE
		STREET 2:		#2382
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02109
		BUSINESS PHONE:		857-301-6857

	MAIL ADDRESS:	
		STREET 1:		6 LIBERTY SQUARE
		STREET 2:		#2382
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02109
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-1
<SEQUENCE>1
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<DESCRIPTION>S-1
<TEXT>
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    <title>tm2430338-1_s1 - none - 4.7343949s</title>
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        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a>
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          <font style="letter-spacing:-0.18pt;">As filed with the Securities and Exchange Commission on December 6, 2024</font><font style="font-weight:normal;letter-spacing:0.18pt;"> </font>
        </div>
        <div style="margin-top:2pt; text-align:right; width:456pt; line-height:10pt;font-weight:bold;">
          <font style="letter-spacing:-0.18pt;">Registration No. 333-&#8199;&#8199;&#8199;&#8199;&#8199;&#8199;</font>&#8203;</div>
        <div style="margin-top:2.3pt; width:456pt;">
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          <font style="letter-spacing:-0.32pt;">UNITED STATES </font>
          <br >
          <font style="letter-spacing:-0.32pt;">SECURITIES AND EXCHANGE COMMISSION </font>
          <br >
          <font style="font-size:9pt;letter-spacing:-0.18pt;">Washington, D.C. 20549</font><font style="font-weight:normal;letter-spacing:0.32pt;"> </font>
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        <div style="margin-top:4pt; text-align:center; width:456pt; line-height:17pt;font-weight:bold;font-size:16pt;">
          <font style="letter-spacing:-0.32pt;">FORM S-1 </font>
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        <div style="margin-top:-0.2pt; text-align:center; width:456pt; line-height:11.5pt;font-weight:bold;">
          <font style="letter-spacing:-0.18pt;">REGISTRATION STATEMENT UNDER THE </font>
          <br >
          <font style="letter-spacing:-0.18pt;">SECURITIES ACT OF 1933</font><font style="font-weight:normal;font-size:16pt;">&#8203;<font style="letter-spacing:0.32pt;"> </font></font>
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        <div style="margin-top:4pt; text-align:center; width:456pt; line-height:10.5pt;font-size:16pt;">
          <font style="font-weight:bold;letter-spacing:-0.32pt;">TRANSCODE THERAPEUTICS, INC. </font>
          <br >
          <font style="font-size:9pt;letter-spacing:0.18pt;">(Exact name of registrant as specified in its charter)</font><font style="letter-spacing:0.32pt;"> </font>
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          <div style="margin-left: 0pt; width: 456pt; margin-top: 7.30000000000001pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
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            <td style="padding:0pt;border-bottom:1px solid #000000; width:0pt;">&#8203;</td>
            <td style="border-bottom:1px solid #000000;padding:0.51pt 0pt 2.655pt 0pt; width:144pt;">
              <div style="text-align:center;">
                <font style="letter-spacing:-0.18pt;">Delaware</font>
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            <td style="padding:0pt;border-bottom:1px solid #000000; width:6pt;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #000000; width:6pt;">&#8203;</td>
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              <div style="text-align:center;">
                <font style="letter-spacing:-0.18pt;">2834</font>
              </div>
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            <td style="padding:0pt;border-bottom:1px solid #000000; width:6pt;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #000000; width:6pt;">&#8203;</td>
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              <div style="text-align:center;">
                <font style="letter-spacing:-0.18pt;">81-1065054</font>
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            <td style="padding:0pt;border-bottom:1px solid #000000; width:0pt;">&#8203;</td>
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            <td style="padding:3.26pt 0pt 2.655pt 0pt; width:144pt;">
              <div style="text-align:center;">
                <font style="letter-spacing:0.18pt;">(State or other jurisdiction of</font>
                <br >
                <font style="letter-spacing:0.18pt;">incorporation or organization) </font>
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            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:3.26pt 0pt 2.655pt 0pt; width:144pt;">
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                <font style="letter-spacing:0.18pt;">(Primary Standard Industrial</font>
                <br >
                <font style="letter-spacing:0.18pt;">Classification Code Number) </font>
              </div>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:3.26pt 0pt 2.655pt 0pt; width:144pt;">
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                <font style="letter-spacing:0.18pt;">(I.R.S. Employer</font>
                <br >
                <font style="letter-spacing:0.18pt;">Identification No.)</font>
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            </td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
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        <div style="margin-top:7.8pt; text-align:center; width:456pt; line-height:9.5pt;font-weight:bold;">
          <font style="letter-spacing:-0.18pt;">6 Liberty Square - #2382</font>
          <br >
          <font style="letter-spacing:-0.18pt;">Boston, MA 02109 </font>
          <br >
          <font style="letter-spacing:-0.18pt;">(857-837-3099)</font>
          <br >
          <font style="font-weight:normal;letter-spacing:0.18pt;">(Address, including zip code, and telephone number, including area code, of registrant&#8217;s principal executive offices) </font>
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        <div style="margin-top:4pt; text-align:center; width:456pt; line-height:9.5pt;font-weight:bold;">
          <font style="letter-spacing:-0.18pt;">Thomas A. Fitzgerald </font>
          <br >
          <font style="letter-spacing:-0.18pt;">Interim Chief Executive Officer and Chief Financial Officer </font>
          <br >
          <font style="letter-spacing:-0.18pt;">TransCode Therapeutics, Inc.</font>
          <br >
          <font style="letter-spacing:-0.18pt;">6 Liberty Square, #2382 </font>
          <br >
          <font style="letter-spacing:-0.18pt;">Boston, MA 02109 </font>
          <br >
          <font style="letter-spacing:-0.18pt;">(857) 837-3099</font>
          <br >
          <font style="font-weight:normal;letter-spacing:0.18pt;">(Name, address, including zip code, and telephone number, including area code, of agent for service) </font>
        </div>
        <div style="margin-top:4pt; text-align:center; width:456pt; line-height:10pt;font-weight:bold;">
          <font style="letter-spacing:-0.18pt;">Copy to:</font><font style="font-weight:normal;letter-spacing:0.18pt;"> </font>
        </div>
        <div style="margin-top:4pt; text-align:center; width:456pt; line-height:9.5pt;font-weight:bold;">
          <font style="letter-spacing:-0.18pt;">Michael Bison</font>
          <br >
          <font style="letter-spacing:-0.18pt;">Finnbarr Murphy</font>
          <br >
          <font style="letter-spacing:-0.18pt;">Goodwin Procter LLP</font>
          <br >
          <font style="letter-spacing:-0.18pt;">100 Northern Avenue </font>
          <br >
          <font style="letter-spacing:-0.18pt;">Boston, MA 02210 </font>
          <br >
          <font style="letter-spacing:-0.18pt;">(617) 570-1000</font><font style="font-weight:normal;letter-spacing:0.18pt;"> </font>
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        <div style="margin-top:4pt; width:456pt; line-height:9.5pt;">
          <font style="font-weight:bold;letter-spacing:-0.18pt;">Approximate date of commencement of proposed sale to the public:</font><font style="letter-spacing:0.18pt;"> From time to time after the Registration Statement becomes effective. </font>
        </div>
        <div style="margin-top:4pt; width:456pt; line-height:9.5pt;">
          <font style="letter-spacing:0.18pt;">If any of the securities being registered on this form are to be offered on a delayed or continuous basis pursuant to Rule&#160;415 under the Securities Act of 1933, check the following box. &#9744; </font>
        </div>
        <div style="margin-top:4pt; width:456pt; line-height:9.5pt;">
          <font style="letter-spacing:0.18pt;">If this form is filed to register additional securities for an offering pursuant to Rule&#160;462(b) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. &#9744; </font>
        </div>
        <div style="margin-top:4pt; width:456pt; line-height:9.5pt;">
          <font style="letter-spacing:0.18pt;">If this form is a post-effective amendment filed pursuant to Rule&#160;462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. &#9744; </font>
        </div>
        <div style="margin-top:4pt; width:456pt; line-height:9.5pt;">
          <font style="letter-spacing:0.18pt;">If this Form is a post-effective amendment filed pursuant to Rule&#160;462(d) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. &#9744; </font>
        </div>
        <div style="margin-top:4pt; width:456pt; line-height:9.5pt;">
          <font style="letter-spacing:0.18pt;">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated filer,&#8221; &#8220;smaller reporting company,&#8221; and &#8220;emerging growth company&#8221; in Rule&#160;12b-2 of the Exchange Act. </font>
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              <div style=" float:left; line-height:9pt; text-align:left; width:96pt;white-space:nowrap;">
                <font style="letter-spacing:0.18pt;">Large accelerated filer</font>
                <br >
              </div>
              <div style=" line-height:9pt; text-align:left; margin-left:96pt;">
                <!--blacklining:none;-->
                <font style="letter-spacing:0.18pt;">&#9744; </font>
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              <div style=" float:left; line-height:9pt; text-align:left; width:120pt;white-space:nowrap;">
                <font style="letter-spacing:0.18pt;">Accelerated filer</font>
                <br >
              </div>
              <div style=" line-height:9pt; text-align:left; margin-left:120pt;">
                <!--blacklining:none;-->
                <font style="letter-spacing:0.18pt;">&#9744; </font>
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              <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
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            <td style="padding:2.53pt 0pt 0.78pt 0pt; width:222pt;">
              <div style=" float:left; line-height:9pt; text-align:left; width:96pt;white-space:nowrap;">
                <font style="letter-spacing:0.18pt;">Non-accelerated filer</font>
                <br >
              </div>
              <div style=" line-height:9pt; text-align:left; margin-left:96pt;">
                <!--blacklining:none;-->
                <font style="letter-spacing:0.18pt;">&#9746; </font>
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              <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
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            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:2.53pt 0pt 0.78pt 0pt; width:222pt;">
              <div style=" float:left; line-height:9pt; text-align:left; width:120pt;white-space:nowrap;">
                <font style="letter-spacing:0.18pt;">Smaller reporting company</font>
                <br >
              </div>
              <div style=" line-height:9pt; text-align:left; margin-left:120pt;">
                <!--blacklining:none;-->
                <font style="letter-spacing:0.18pt;">&#9746; </font>
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              <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
            </td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
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          <tr style="line-height:8.97000000000003pt;white-space:nowrap;text-align:left;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:9pt;">
            <td style="padding:0pt; width:0pt;">&#8203;</td>
            <td style="padding:0pt 0pt 0.5pt 0pt; width:222pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:2.53pt 0pt 0.78pt 0pt; width:222pt;white-space:normal;">
              <div style=" float:left; line-height:9pt; text-align:left; width:120pt;white-space:nowrap;">
                <font style="letter-spacing:0.18pt;">Emerging growth company</font>
                <br >
              </div>
              <div style=" line-height:9pt; text-align:left; margin-left:120pt;">
                <!--blacklining:none;-->
                <font style="letter-spacing:0.18pt;">&#9746;</font>
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              <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
            </td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
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        </table>
        <div style="margin-top:7.91pt; width:456pt; line-height:9.5pt;">
          <font style="letter-spacing:0.18pt;">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section&#160;7(a)(2)(B) of the Securities Act. &#9744; </font>
        </div>
        <div style="margin-top:4pt; width:456pt; line-height:9.5pt;font-weight:bold;">
          <font style="letter-spacing:-0.18pt;">The Registrant hereby amends this registration statement on such date or dates as may be necessary to delay its effective date until the Registrant shall file a further amendment which specifically states that this registration statement shall thereafter become effective in accordance with Section&#160;8(a) of the Securities Act of 1933 or until the registration statement shall become effective on such date as the Securities and Exchange Commission, acting pursuant to said Section&#160;8(a), may determine.</font><font style="font-weight:normal;letter-spacing:0.18pt;"> </font>
        </div>
        <div style="margin-top:5.4pt; width:456pt;">
          <div style="margin-left: 0pt; width: 456pt; margin-top: 5.39999999999998pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
        </div>
        <div style="margin-top:1.9pt; width:456pt;">
          <div style="margin-left: 0pt; width: 456pt; margin-top: 1.90000000000009pt; font-size: 2pt; line-height: 0pt; border-bottom: 2pt solid #000000; ">&#8203;</div>
        </div>
      </div>
      <hr >
    </div>
    <div style="page-break-after:always; width:595.3pt;margin-left:auto;margin-right:auto;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
      <div style="padding:0pt;margin:0pt;font-family:calibri, arial, sans-serif;font-weight:normal;font-style:normal;font-size:8pt;line-height:8pt;">
        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a>
      </div>
      <div style="margin-top:27.85pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
        <div style="width:456pt; line-height:11.5pt;font-weight:bold;color:#FC0014;">
          <font style="letter-spacing:-0.2pt;">The information in this prospectus is not complete and may be changed. The selling stockholders named in this prospectus may not sell these securities until the registration statement becomes effective. This prospectus is not an offer to sell these securities, and the selling stockholders named in this prospectus are not soliciting offers to buy these securities in any jurisdiction where the offer for sale is not permitted.</font><font style="font-weight:normal;color:#000000;letter-spacing:0.2pt;"> </font>
        </div>
        <div style="margin-top:12pt; width:456pt; line-height:12pt;font-weight:bold;color:#FC0014;">
          <font style="text-transform:uppercase;letter-spacing:-0.2pt;">Subject To Completion, Dated December 6, 2024</font><font style="font-weight:normal;color:#000000;letter-spacing:0.2pt;"> </font>
        </div>
        <div style="margin-top:12pt; width:456pt; line-height:14pt;font-weight:bold;font-size:12pt;">
          <font style="letter-spacing:-0.24pt;">PROSPECTUS</font><font style="font-weight:normal;letter-spacing:0.24pt;"> </font>
        </div>
        <div style="position:relative;margin-top:10pt; text-align:center; width:456pt;">
          <img src="lg_transcodetheratm-4c.jpg" alt="[MISSING IMAGE: lg_transcodetheratm-4c.jpg]" height="59" width="403" >
        </div>
        <div style="margin-top:12.6pt; width:456pt; line-height:16pt;font-weight:bold;font-size:14pt;">
          <font style="letter-spacing:-0.28pt;">173,033 Shares of Common Stock</font><font style="font-weight:normal;letter-spacing:0.28pt;"> </font>
        </div>
        <div style="margin-top:8pt; width:456pt; line-height:16pt;font-weight:bold;font-size:14pt;">
          <font style="letter-spacing:-0.28pt;">470,007 shares of Common Stock underlying the Pre-Funded Warrants</font><font style="font-weight:normal;letter-spacing:0.28pt;"> </font>
        </div>
        <div style="margin-top:8pt; width:456pt; line-height:16pt;font-weight:bold;font-size:14pt;">
          <font style="letter-spacing:-0.28pt;">Up to 4,050,953 shares of Common Stock underlying the Series&#160;C Warrants</font><font style="font-weight:normal;letter-spacing:0.28pt;"> </font>
        </div>
        <div style="margin-top:8pt; width:456pt; line-height:16pt;font-weight:bold;font-size:14pt;">
          <font style="letter-spacing:-0.28pt;">Up to 12,152,856 shares of Common Stock underlying the Series&#160;D Warrants</font><font style="font-weight:normal;letter-spacing:0.28pt;"> </font>
        </div>
        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:0.2pt;">This prospectus relates to the resale by the selling stockholders identified in this prospectus under the section &#8220;</font><font style="font-style:italic;letter-spacing:0.2pt;">The Selling Stockholders</font><font style="letter-spacing:0.2pt;">,&#8221; or their pledgees, donees, transferees or other successors in interest, from time to time, of (i)&#160;173,033 shares of our common stock, par value $0.0001 per share, (&#8220;Common Stock&#8221;) issued in a private placement of our securities (the &#8220;PIPE&#8221;), (ii)&#160;470,007 shares of Common Stock (the &#8220;PIPE PFW Shares&#8221;) issuable upon exercise of pre-funded warrants (each, a &#8220;PIPE PFW&#8221;), (iii)&#160;up to 4,050,953 common shares underlying warrants (the &#8220;Series&#160;C Common Warrants&#8221;) to purchase Common Stock (the &#8220;Series&#160;C Common Warrant Shares&#8221;) and (iv)&#160;up to 12,152,856 common shares underlying warrants to purchase Common Stock (the &#8220;Series&#160;D Common Warrants&#8221; and together with the Series&#160;C Common Warrants, the &#8220;Common Warrants&#8221;; the Common Warrants together with the PIPE PFW, the &#8220;Warrants&#8221;) and together with the Series&#160;C Common Warrant Shares, the &#8220;Common Warrant Shares,&#8221; the Common Warrant Shares together with the PIPE PFW Shares, the &#8220;Warrant Shares&#8221;) sold to the Selling Stockholders and certain of their affiliates (the &#8220;Selling Stockholders&#8221;) pursuant to the stock purchase agreement dated as of November&#160;26, 2024, (the &#8220;PIPE SPA&#8221;) by and between TransCode Therapeutics, Inc. (the &#8220;Company&#8221;), and the Selling Stockholders. We are registering the offer, sale and resale, from time to time, of the Common Stock issued in the PIPE, the PIPE PFW Shares and the Warrant Shares (collectively, the &#8220;Resale Shares&#8221;) on behalf of the Selling Stockholders. </font>
        </div>
        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:0.2pt;">Each Series&#160;C Warrant has an initial exercise price per share of $15.675 and will be exercisable beginning on the date on which Stockholder Approval (as defined below) is received and deemed effective (the &#8220;</font><font style=" text-decoration:underline #000000 solid;letter-spacing:0.2pt;">Initial Exercise Date</font><font style="letter-spacing:0.2pt;">&#8221; or the &#8220;</font><font style=" text-decoration:underline #000000 solid;letter-spacing:0.2pt;">Stockholder Approval Date</font><font style="letter-spacing:0.2pt;">&#8221;). The Series&#160;C Warrants will expire on the five-year anniversary of the Initial Exercise Date. Additionally, the Series&#160;C Warrants provide for an adjustment to the exercise price and number of shares underlying such the Series&#160;C Warrants upon the Company&#8217;s issuance of common shares or common share equivalents at a price per share that is less than the exercise price of the Series&#160;C Warrants, subject to a floor price of $2.4882 (the &#8220;</font><font style=" text-decoration:underline #000000 solid;letter-spacing:0.2pt;">Floor Price</font><font style="letter-spacing:0.2pt;">&#8221;). </font>
        </div>
        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:0.2pt;">The Series&#160;D Warrants have an initial exercise price per share of $15.675 and will be exercisable beginning on the Initial Exercise Date. The Series&#160;D Warrants will expire two and one-half&#160;years after the Initial Exercise Date. Under an alternative cashless exchange provision in the Series&#160;D Warrants, holders thereof have the right to receive an aggregate number of shares equal to the product of (i)&#160;the aggregate number of common shares that would be issuable upon a cash exercise of the Series&#160;D Warrants and (ii)&#160;3.0. </font>
        </div>
        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:0.2pt;">In addition, on the 11th trading day following each of (i)&#160;the later of (A)&#160;the Stockholder Approval Date and (B)&#160;the Effective Date (as that term is defined in the PIPE SPA) and (ii)&#160;each subsequent date that a Registration Statement (as that term is defined in the PIPE SPA) is declared effective by the Securities and Exchange Commission, if any (each such trading day, a &#8220;</font><font style=" text-decoration:underline #000000 solid;letter-spacing:0.2pt;">Reset Date</font><font style="letter-spacing:0.2pt;">&#8221;), the Series&#160;C Warrants and the Series&#160;D Warrants contain a reset of the exercise price to a price equal to the lesser of (i)&#160;the then applicable exercise price and (ii)&#160;the greater of the Floor Price and the lowest volume weighted average price for the ten trading days immediately preceding the Reset Date. Upon such reset of the exercise price, the number of </font>
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    <div style="page-break-after:always; width:595.3pt;margin-left:auto;margin-right:auto;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
      <div style="padding:0pt;margin:0pt;font-family:calibri, arial, sans-serif;font-weight:normal;font-style:normal;font-size:8pt;line-height:8pt;">
        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a>
      </div>
      <div style="margin-top:27.85pt;min-height:706pt;margin-left:69.66pt;width:456pt;">
        <div style="width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">shares issuable under the Common Warrants shall be increased such that the aggregate exercise price of the Common Warrants shall remain unchanged following such reset. </font>
        </div>
        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">The issuance of shares of Common Stock upon exercise of the Common Warrants is subject to stockholder approval under applicable rules and regulations of The Nasdaq Stock Market LLC (&#8220;</font><font style=" text-decoration:underline #000000 solid;letter-spacing:0.2pt;">Nasdaq</font><font style="letter-spacing:0.2pt;">&#8221;) (&#8220;</font><font style=" text-decoration:underline #000000 solid;letter-spacing:0.2pt;">Stockholder Approval</font><font style="letter-spacing:0.2pt;">&#8221; and the date on which Stockholder Approval is received and deemed effective, the &#8220;</font><font style=" text-decoration:underline #000000 solid;letter-spacing:0.2pt;">Stockholder Approval Date</font><font style="letter-spacing:0.2pt;">&#8221;). The Company intends to hold a shareholder meeting to obtain Stockholder Approval within 70&#160;days following the closing of the PIPE. </font>
        </div>
        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">The Selling Stockholders may resell or dispose of the Resale Shares, or interests therein, at fixed prices, at prevailing market prices at the time of sale or at prices negotiated with purchasers, to or through underwriters, broker-dealers, agents, or through any other means described in the section of this prospectus titled &#8220;</font><font style="font-style:italic;letter-spacing:0.2pt;">Plan of Distribution</font><font style="letter-spacing:0.2pt;">&#8221;. The Selling Stockholders will each bear their respective commissions and discounts, if any, attributable to the sale or disposition of the Resale Shares, or interests therein, held by such Selling Stockholder. We will bear all other costs, expenses and fees in connection with the registration of the resale of the Resale Shares. We will not receive any of the proceeds from the sale by the Selling Stockholders of the Common Stock issued in the PIPE. We will, however, receive the net proceeds of any Warrants exercised for cash. </font>
        </div>
        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">We are an &#8220;emerging growth company&#8221; as defined in Section&#160;2(a) of the Securities Act of 1933, as amended (the &#8220;Securities Act&#8221;), and, as such, have elected to comply with certain reduced disclosure and regulatory requirements. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">Our Common Stock is listed on The Nasdaq Capital Market, or Nasdaq, under the symbol &#8220;RNAZ.&#8221; On December&#160;5, 2024, the last reported sale price of our Common Stock was $8.70 per share. You are urged to obtain current market quotations for our Common Stock. </font>
        </div>
        <div style="margin-top:12pt; width:456pt; line-height:12pt;font-weight:bold;">
          <font style="letter-spacing:-0.2pt;">We are not in compliance with certain listing requirements for continued listing of our stock on The Nasdaq Capital Market, or the Exchange. There can be no assurance that we will be successful in our efforts to maintain our Nasdaq listing. If our common stock ceases to be listed for trading on The Nasdaq Capital Market, we expect that our common stock would be traded on one of the three tiered marketplaces of the OTC Markets Group. See &#8220;Risk Factors&#8221;&#8201;&#8212;&#8201;&#8220;</font><font style="font-style:italic;letter-spacing:-0.2pt;">We could lose our listing on the Nasdaq Capital Market. The loss of our Nasdaq listing would in all likelihood make our common stock significantly less liquid and adversely affect its value</font><font style="font-weight:normal;letter-spacing:0.2pt;">&#8221; for more details. </font>
        </div>
        <div style="margin-top:12pt; width:456pt; line-height:12pt;font-weight:bold;">
          <font style="letter-spacing:-0.2pt;">Investing in our securities involves a high degree of risk. You should review carefully the risks and uncertainties described under the heading &#8220;</font><font style="font-style:italic;letter-spacing:-0.2pt;">Risk Factors</font><font style="letter-spacing:-0.2pt;">&#8221; contained in this prospectus and under similar headings in the other documents that are incorporated by reference into this prospectus as described on page <a href="#tRIFA">16</a> of this prospectus.</font><font style="font-weight:normal;letter-spacing:0.2pt;"> </font>
        </div>
        <div style="margin-top:12pt; width:456pt; line-height:12pt;font-weight:bold;">
          <font style="letter-spacing:-0.2pt;">Neither the Securities and Exchange Commission (the &#8220;SEC&#8221;) nor any state securities commission has approved or disapproved of these securities or passed upon the accuracy or adequacy of this prospectus. Any representation to the contrary is a criminal offense.</font><font style="font-weight:normal;letter-spacing:0.2pt;"> </font>
        </div>
        <div style="margin-top:12pt; text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">The date of this Prospectus is &#8199;&#8199;&#8199;&#8199;&#8199;&#8199;&#8199;&#8199;&#8199;, 2024.</font>
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    </div>
    <div style="page-break-after:always; width:595.3pt;margin-left:auto;margin-right:auto;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
      <div style="padding:0pt;margin:0pt;font-family:calibri, arial, sans-serif;font-weight:normal;font-style:normal;font-size:8pt;line-height:8pt;">
        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a><a name="TOC">&#8203;</a>
      </div>
      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:6pt; width:456pt; line-height:14pt;font-size:12pt;">
          <font style="letter-spacing:0.24pt;">&#160;</font>
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        <div style="margin-top:5.833pt; width:456pt;">
          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
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      <div style="margin-top:6pt;margin-bottom:315.5pt;margin-left:69.66pt;width:456pt;">
        <div style="text-align:center; width:456pt; line-height:20pt;font-weight:bold;font-size:18pt;">
          <font style="letter-spacing:-0.36pt;">Table of Contents</font><font style="font-weight:normal;letter-spacing:0.36pt;"> </font>
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        <table style="width:456pt;height:265.5pt;margin-top:14pt;border-collapse: collapse;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
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            <td style="border-bottom:1px solid #FFFFFF;padding:0pt 0pt 0.5pt 0pt; width:423.93pt;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">&#8203;</td>
            <td style="border-bottom:1px solid #000000;padding:0pt 0pt 2.5pt 0pt;text-align:center;" colspan="4">
              <div style="white-space:nowrap; text-align:center;">
                <font style="letter-spacing:0.2pt;">Page </font>
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            <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:0pt;">&#8203;</td>
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            <td style="padding:3.25pt 0pt 1.5pt 0pt; width:423.93pt;text-align:left;">
              <div style="white-space:nowrap;">
                <a href="#tATP"><font style="letter-spacing:0.2pt;">About This Prospectus </font></a>
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            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:5.035pt;width:0pt;">&#8203;</td>
            <td style="padding:3.25pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3.25pt 0pt 1.5pt 0pt; min-width:10.5pt; text-align:right; white-space:nowrap;">
              <font style="letter-spacing:0.2pt;"><a href="#tATP">ii</a></font> <a href="#tATP"></a></td>
            <td style="padding:0pt;padding-left:5.035pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
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            <td style="padding:3.5pt 0pt 1.5pt 0pt; width:423.93pt;text-align:left;">
              <div style="white-space:nowrap;">
                <a href="#tRSS"><font style="letter-spacing:0.2pt;">Reverse Stock Split </font></a>
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            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:5.035pt;width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:10.5pt; text-align:right; white-space:nowrap;">
              <font style="letter-spacing:0.2pt;"><a href="#tRSS">ii</a></font> <a href="#tRSS"></a></td>
            <td style="padding:0pt;padding-left:5.035pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
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            <td style="padding:3.5pt 0pt 1.5pt 0pt; width:423.93pt;text-align:left;">
              <div style="white-space:nowrap;">
                <a href="#tCOIN"><font style="letter-spacing:0.2pt;">Corporate Information </font></a>
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            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:5.035pt;width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:10.5pt; text-align:right; white-space:nowrap;">
              <font style="letter-spacing:0.2pt;"><a href="#tCOIN">iii</a></font> <a href="#tCOIN"></a></td>
            <td style="padding:0pt;padding-left:5.035pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
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            <td style="padding:3.5pt 0pt 1.5pt 0pt; width:423.93pt;text-align:left;">
              <div style="white-space:nowrap;">
                <a href="#tFOST"><font style="letter-spacing:0.2pt;">Forward-Looking Statements </font></a>
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            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:5.035pt;width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:10.5pt; text-align:right; white-space:nowrap;">
              <font style="letter-spacing:0.2pt;"><a href="#tFOST">v</a></font> <a href="#tFOST"></a></td>
            <td style="padding:0pt;padding-left:5.035pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
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          <tr style="line-height:10pt;background-color:#CCEEFF;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:3.5pt 0pt 1.5pt 0pt; width:423.93pt;text-align:left;">
              <div style="white-space:nowrap;">
                <a href="#tSUM"><font style="letter-spacing:0.2pt;">Summary </font></a>
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            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:5.035pt;width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:10.5pt; text-align:right; white-space:nowrap;">
              <font style="letter-spacing:0.2pt;"><a href="#tSUM">1</a></font> <a href="#tSUM"></a></td>
            <td style="padding:0pt;padding-left:5.035pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
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            <td style="padding:3.5pt 0pt 1.5pt 0pt; width:423.93pt;text-align:left;">
              <div style="white-space:nowrap;">
                <a href="#tTHOF"><font style="letter-spacing:0.2pt;">The Offering </font></a>
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            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:5.035pt;width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:10.5pt; text-align:right; white-space:nowrap;">
              <font style="letter-spacing:0.2pt;"><a href="#tTHOF">14</a></font> <a href="#tTHOF"></a></td>
            <td style="padding:0pt;padding-left:5.035pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
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          <tr style="line-height:10pt;background-color:#CCEEFF;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:3.5pt 0pt 1.5pt 0pt; width:423.93pt;text-align:left;">
              <div style="white-space:nowrap;">
                <a href="#tRIFA"><font style="letter-spacing:0.2pt;">Risk Factors </font></a>
              </div>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:5.035pt;width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:10.5pt; text-align:right; white-space:nowrap;">
              <font style="letter-spacing:0.2pt;"><a href="#tRIFA">16</a></font> <a href="#tRIFA"></a></td>
            <td style="padding:0pt;padding-left:5.035pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
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            <td style="padding:3.5pt 0pt 1.5pt 0pt; width:423.93pt;text-align:left;">
              <div style="white-space:nowrap;">
                <a href="#tUOP"><font style="letter-spacing:0.2pt;">Use of Proceeds </font></a>
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            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:5.035pt;width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:10.5pt; text-align:right; white-space:nowrap;">
              <font style="letter-spacing:0.2pt;"><a href="#tUOP">18</a></font> <a href="#tUOP"></a></td>
            <td style="padding:0pt;padding-left:5.035pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:10pt;background-color:#CCEEFF;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:3.5pt 0pt 1.5pt 0pt; width:423.93pt;text-align:left;">
              <div style="white-space:nowrap;">
                <a href="#tDOOP"><font style="letter-spacing:0.2pt;">Determination of Offering Price </font></a>
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            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:5.035pt;width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:10.5pt; text-align:right; white-space:nowrap;">
              <font style="letter-spacing:0.2pt;"><a href="#tDOOP">19</a></font> <a href="#tDOOP"></a></td>
            <td style="padding:0pt;padding-left:5.035pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
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            <td style="padding:3.5pt 0pt 1.5pt 0pt; width:423.93pt;text-align:left;">
              <div style="white-space:nowrap;">
                <a href="#tTSS"><font style="letter-spacing:0.2pt;">The Selling Stockholders </font></a>
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            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:5.035pt;width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:10.5pt; text-align:right; white-space:nowrap;">
              <font style="letter-spacing:0.2pt;"><a href="#tTSS">20</a></font> <a href="#tTSS"></a></td>
            <td style="padding:0pt;padding-left:5.035pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:10pt;background-color:#CCEEFF;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:3.5pt 0pt 1.5pt 0pt; width:423.93pt;text-align:left;">
              <div style="white-space:nowrap;">
                <a href="#tDOSB"><font style="letter-spacing:0.2pt;">Description of Securities Being Registered </font></a>
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            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:5.035pt;width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:10.5pt; text-align:right; white-space:nowrap;">
              <font style="letter-spacing:0.2pt;"><a href="#tDOSB">24</a></font> <a href="#tDOSB"></a></td>
            <td style="padding:0pt;padding-left:5.035pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
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            <td style="padding:3.5pt 0pt 1.5pt 0pt; width:423.93pt;text-align:left;">
              <div style="white-space:nowrap;">
                <a href="#tCUFI"><font style="letter-spacing:0.2pt;">Certain U.S. Federal Income Tax Considerations </font></a>
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            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:5.035pt;width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:10.5pt; text-align:right; white-space:nowrap;">
              <font style="letter-spacing:0.2pt;"><a href="#tCUFI">29</a></font> <a href="#tCUFI"></a></td>
            <td style="padding:0pt;padding-left:5.035pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
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            <td style="padding:3.5pt 0pt 1.5pt 0pt; width:423.93pt;text-align:left;">
              <div style="white-space:nowrap;">
                <a href="#tPOD"><font style="letter-spacing:0.2pt;">Plan of Distribution </font></a>
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            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:5.035pt;width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:10.5pt; text-align:right; white-space:nowrap;">
              <font style="letter-spacing:0.2pt;"><a href="#tPOD">35</a></font> <a href="#tPOD"></a></td>
            <td style="padding:0pt;padding-left:5.035pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
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            <td style="padding:3.5pt 0pt 1.5pt 0pt; width:423.93pt;text-align:left;">
              <div style="white-space:nowrap;">
                <a href="#tLEMA"><font style="letter-spacing:0.2pt;">Legal Matters </font></a>
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            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:5.035pt;width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:10.5pt; text-align:right; white-space:nowrap;">
              <font style="letter-spacing:0.2pt;"><a href="#tLEMA">37</a></font> <a href="#tLEMA"></a></td>
            <td style="padding:0pt;padding-left:5.035pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
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            <td style="padding:3.5pt 0pt 1.5pt 0pt; width:423.93pt;text-align:left;">
              <div style="white-space:nowrap;">
                <a href="#tEXP"><font style="letter-spacing:0.2pt;">Experts </font></a>
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            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
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            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:10.5pt; text-align:right; white-space:nowrap;">
              <font style="letter-spacing:0.2pt;"><a href="#tEXP">37</a></font> <a href="#tEXP"></a></td>
            <td style="padding:0pt;padding-left:5.035pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
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            <td style="padding:3.5pt 0pt 1.5pt 0pt; width:423.93pt;text-align:left;">
              <div style="white-space:nowrap;">
                <a href="#tWYCF"><font style="letter-spacing:0.2pt;">Where You Can Find More Information </font></a>
              </div>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:5.035pt;width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:10.5pt; text-align:right; white-space:nowrap;">
              <font style="letter-spacing:0.2pt;"><a href="#tWYCF">37</a></font> <a href="#tWYCF"></a></td>
            <td style="padding:0pt;padding-left:5.035pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
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            <td style="padding:3.5pt 0pt 1.5pt 0pt; width:423.93pt;text-align:left;">
              <div style="white-space:nowrap;">
                <a href="#tIOCD"><font style="letter-spacing:0.2pt;">Incorporation of Certain Documents by Reference </font></a>
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            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:5.035pt;width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:10.5pt; text-align:right; white-space:nowrap;">
              <font style="letter-spacing:0.2pt;"><a href="#tIOCD">38</a></font>
            </td>
            <td style="padding:0pt;padding-left:5.035pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
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        <div style="margin-left:10pt; text-align:center; width:446pt; line-height:9pt;font-size:8pt;">
          <font style="letter-spacing:0.16pt;"> </font>
        </div>
      </div>
      <div style="margin-top:0pt;height:12pt;margin-left:69.66pt;width:456pt;">
        <div style="text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">&#160;</font>
          <br >
        </div>
      </div>
      <div style="margin-top:2pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
        <div style="width:456pt;">
          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
        </div>
        <div style="margin-top:3pt; text-align:right; width:456pt; line-height:13pt;">
          <font style="letter-spacing:0.2pt;">i</font>&#8203;</div>
      </div>
      <hr >
    </div>
    <div style="page-break-after:always; width:595.3pt;margin-left:auto;margin-right:auto;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
      <div style="padding:0pt;margin:0pt;font-family:calibri, arial, sans-serif;font-weight:normal;font-style:normal;font-size:8pt;line-height:8pt;">
        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a><a name="tATP">&#8203;</a><a name="tRSS">&#8203;</a>
      </div>
      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:6pt; width:456pt; line-height:14pt;font-size:12pt;">
          <font style="letter-spacing:0.24pt;">&#160;</font>
        </div>
        <div style="margin-top:5.833pt; width:456pt;">
          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
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      <div style="margin-top:6pt;margin-left:69.66pt;width:456pt;">
        <div style="text-align:center; width:456pt; line-height:20pt;font-weight:bold;font-size:18pt;">
          <font style="letter-spacing:-0.36pt;">About This Prospectus</font><font style="font-weight:normal;letter-spacing:0.36pt;"> </font>
        </div>
        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:0.2pt;">This prospectus provides you with a general description of the Resale Shares that may be resold by the Selling Stockholders. In certain circumstances, we may provide a prospectus supplement that will contain specific information about the terms of a particular offering by the Selling Stockholders. We also may provide a prospectus supplement that may contain material information relating to these offerings. The prospectus supplement may also add information to, or update or change information contained in, this prospectus. To the extent there is a conflict between the information contained in this prospectus and any prospectus supplement, you should rely on the information in the prospectus supplement, provided that if any statement in one of these documents is inconsistent with a statement in another document having a later date&#8201;&#8212;&#8201;for example, a document incorporated by reference in this prospectus or any prospectus supplement&#8201;&#8212;&#8201;the statement in the later-dated document modifies or supersedes the earlier statement. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:0.2pt;">You should read both this prospectus and any applicable prospectus supplement together with the additional information about our company to which we refer you in the sections of this prospectus titled &#8220;</font><font style="font-style:italic;letter-spacing:0.2pt;">Where You Can Find More Information</font><font style="letter-spacing:0.2pt;">&#8221; and &#8220;</font><font style="font-style:italic;letter-spacing:0.2pt;">Incorporation of Certain Documents by Reference</font><font style="letter-spacing:0.2pt;">.&#8221; You should rely only on the information contained in or incorporated by reference into this prospectus and any prospectus supplement. Neither we nor the Selling Stockholders have authorized any dealer, salesperson or other person to provide you with different information. You should not assume that the information in this prospectus or any prospectus supplement is accurate as of any date other than the date on the front of those documents or that any document incorporated by reference is accurate as of any date other than its filing date. You should not consider this prospectus to be an offer or solicitation relating to the Resale Shares in any jurisdiction in which such an offer or solicitation relating to the Resale Shares is not authorized. Furthermore, you should not consider this prospectus to be an offer or solicitation relating to the Resale Shares if the person making the offer or solicitation is not qualified to do so, or if it is unlawful for you to receive such an offer or solicitation. </font>
        </div>
        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:0.2pt;">We obtained the industry and market data used throughout this prospectus from our own internal estimates and research, as well as from independent market research, industry and general publications and surveys, governmental agencies, publicly available information and research, and surveys and studies conducted by third parties. Internal estimates are derived from publicly available information released by industry analysts and third-party sources, our internal research and our industry experience, and are based on assumptions made by us based on such data and our knowledge of our industry and market, which we believe to be reasonable. In some cases, we do not expressly refer to the sources from which these data are derived. In addition, while we believe the industry and market data included in this prospectus are reliable and based on reasonable assumptions, such data involve material risks and other uncertainties and are subject to change based on various factors, including those risks discussed in our filings incorporated herein by reference. These and other factors could cause results to differ materially from those expressed in the estimates made by the independent parties or by us. </font>
        </div>
        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:0.2pt;">Unless the context indicates otherwise, when we refer to &#8220;TransCode,&#8221; &#8220;we,&#8221; &#8220;our,&#8221; &#8220;us&#8221; and the &#8220;Company&#8221; in this prospectus, we mean TransCode Therapeutics, Inc., unless otherwise specified. When we refer to &#8220;you,&#8221; we mean the potential purchasers of the Resale Shares. </font>
        </div>
        <div style="margin-top:12pt; text-align:center; width:456pt; line-height:20pt;font-weight:bold;font-size:18pt;">
          <font style="letter-spacing:-0.36pt;">Reverse Stock Split</font><font style="font-weight:normal;letter-spacing:0.36pt;"> </font>
        </div>
        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:0.2pt;">On December&#160;4, 2024, we effected a 1-for-33 reverse stock split of our outstanding common stock, shares either issued and outstanding or held by the Company as treasury stock (the &#8220;December&#160;2024 Reverse Split&#8221;). The December&#160;2024 Reverse Split did not change the number of authorized shares of common stock. </font>
        </div>
        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:0.2pt;">All common stock share and per share data, and exercise price data for applicable common stock equivalents, included in this prospectus, except those in our financial statements and documents incorporated by reference dated prior to the December&#160;2024 Reverse Split, have been retroactively adjusted to reflect the December&#160;2024 Reverse Split. Any fractional shares resulting from the December&#160;2024 Reverse Split have been rounded up to the nearest whole share. </font>
        </div>
      </div>
      <div style="margin-top:2.00000000000002pt;height:12pt;margin-left:69.66pt;width:456pt;">
        <div style="text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">&#160;</font>
          <br >
        </div>
      </div>
      <div style="margin-top:2pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
        <div style="width:456pt;">
          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
        </div>
        <div style="margin-top:3pt; width:456pt; line-height:13pt;">
          <font style="letter-spacing:0.2pt;">ii</font>
        </div>
      </div>
      <hr >
    </div>
    <div style="page-break-after:always; width:595.3pt;margin-left:auto;margin-right:auto;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Helvetica, Arial, sans-serif;font-size:9pt;">
      <div style="padding:0pt;margin:0pt;font-family:calibri, arial, sans-serif;font-weight:normal;font-style:normal;font-size:8pt;line-height:8pt;">
        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a><a name="tCOIN">&#8203;</a>
      </div>
      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:6pt; width:456pt; line-height:14pt;font-family:Times New Roman, Times, serif ;font-size:12pt;">
          <font style="letter-spacing:0.24pt;">&#160;</font>
        </div>
        <div style="margin-top:5.833pt; width:456pt;">
          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
        </div>
      </div>
      <div style="margin-top:6pt;margin-bottom:524pt;margin-left:69.66pt;width:456pt;">
        <div style="text-align:center; width:456pt; line-height:20pt;font-weight:bold;font-family:Times New Roman, Times, serif ;font-size:18pt;">
          <font style="letter-spacing:-0.36pt;">Corporate Information</font><font style="font-weight:normal;letter-spacing:0.36pt;"> </font>
        </div>
        <div style="margin-top:12pt; width:456pt; line-height:12pt;font-family:Times New Roman, Times, serif ;font-size:10pt;">
          <font style="letter-spacing:0.2pt;">We were incorporated in the State of Delaware in January&#160;2016. Our corporate address is 6 Liberty Square,&#160;#2382, Boston, Massachusetts 02109; our telephone number is (857) 837-3099. Our website is www.transcodetherapeutics.com. Information contained in, or that can be accessed through, our website is not incorporated by reference into this prospectus, and you should not consider information on our website to be part of this prospectus. Our design logo and our other registered and common law trade names, trademarks and service marks are the property of TransCode. </font>
        </div>
      </div>
      <div style="margin-top:0pt;height:12pt;margin-left:69.66pt;width:456pt;">
        <div style="text-align:center; width:456pt; line-height:12pt;font-family:Times New Roman, Times, serif ;font-size:10pt;">
          <font style="letter-spacing:0.2pt;">&#160;</font>
          <br >
        </div>
      </div>
      <div style="margin-top:2pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
        <div style="width:456pt;">
          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
        </div>
        <div style="margin-top:3pt; text-align:right; width:456pt; line-height:13pt;font-family:Times New Roman, Times, serif ;font-size:10pt;">
          <font style="letter-spacing:0.2pt;">iii</font>&#8203;</div>
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      <hr >
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    <div style="page-break-after:always; width:595.3pt;margin-left:auto;margin-right:auto;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
      <div style="padding:0pt;margin:0pt;font-family:calibri, arial, sans-serif;font-weight:normal;font-style:normal;font-size:8pt;line-height:8pt;">
        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a><a name="tFOST">&#8203;</a>
      </div>
      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:6pt; width:456pt; line-height:14pt;font-size:12pt;">
          <font style="letter-spacing:0.24pt;">&#160;</font>
        </div>
        <div style="margin-top:5.833pt; width:456pt;">
          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
        </div>
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      <div style="margin-top:6pt;margin-left:69.66pt;width:456pt;">
        <div style="text-align:center; width:456pt; line-height:20pt;font-weight:bold;font-size:18pt;">
          <font style="letter-spacing:-0.36pt;">Forward-Looking Statements</font><font style="font-weight:normal;letter-spacing:0.36pt;"> </font>
        </div>
        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:0.2pt;">This prospectus, including the documents that we incorporate by reference, contains predictive or &#8220;forward-looking statements&#8221; within the meaning of the Private Securities Litigation Reform Act of 1995. All statements other than statements of current or historical fact contained in this prospectus, including statements that express our intentions, plans, objectives, beliefs, expectations, strategies, predictions or any other statements relating to our future activities or other future events or conditions are forward-looking statements. The words &#8220;anticipate,&#8221; &#8220;believe,&#8221; &#8220;continue,&#8221; &#8220;could,&#8221; &#8220;estimate,&#8221; &#8220;expect,&#8221; &#8220;intend,&#8221; &#8220;may,&#8221; &#8220;plan,&#8221; &#8220;predict,&#8221; &#8220;project,&#8221; &#8220;will,&#8221; &#8220;should,&#8221; &#8220;would&#8221; and similar expressions, as they relate to us, are intended to identify forward-looking statements. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:0.2pt;">These statements are based on current expectations, estimates and projections made by management about our business, our industry and other conditions affecting our financial condition, results of operations or business prospects. These statements are not guarantees of future performance and involve risks, uncertainties and assumptions that are difficult to predict. Therefore, actual outcomes and results may differ materially from what is expressed or forecasted in, or implied by, the forward-looking statements due to numerous risks and uncertainties. Factors that could cause such outcomes and results to differ include, but are not limited to, risks and uncertainties arising from: </font>
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          <font style="letter-spacing:0.2pt;">our cash position, our estimates and expectations regarding our capital requirements, cash and expense levels, liquidity sources, our need for additional financing and our ability to obtain, on satisfactory terms or at all, the financing required to support operations, research, development, clinical trials, and commercialization of products; </font>
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          <font style="letter-spacing:0.2pt;">a potential delisting of our common stock from trading on the Nasdaq Capital Market; </font>
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          <font style="letter-spacing:0.2pt;">our ability to continue as a going concern; </font>
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        <div style=" float:left; margin-left:20pt; line-height:12pt; margin-top:5.4pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
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        <div style=" margin-top:5.4pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:40pt;">
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          <font style="letter-spacing:0.2pt;">the results and timing of our preclinical and clinical trial activities, including but not limited to our ability to enroll a sufficient number of patients timely to advance our clinical trials; </font>
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          <font style="letter-spacing:0.2pt;">our ability to expand our therapeutic candidate portfolio through internal research and development or the acquisition or in-licensing of intellectual property assets; </font>
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        <div style=" margin-top:5.4pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:40pt;">
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          <font style="letter-spacing:0.2pt;">the therapeutic benefits, effectiveness and safety of our therapeutic candidates; </font>
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        <div style=" margin-top:5.4pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:40pt;">
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          <font style="letter-spacing:0.2pt;">our ability to receive regulatory approval for our therapeutic candidates in the United States, Europe and other geographies; </font>
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        <div style=" margin-top:5.41pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:40pt;">
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          <font style="letter-spacing:0.2pt;">the expected regulatory approval pathway for our therapeutic candidates; </font>
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          <font style="letter-spacing:0.2pt;">potential changes in regulatory requirements, and delays or negative outcomes from the regulatory approval process; </font>
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        <div style=" margin-top:5.41pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:40pt;">
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          <font style="letter-spacing:0.2pt;">our reliance on third parties for the planning, conduct, management and monitoring of clinical trials, for the manufacture of clinical drug supplies and drug product meeting our specifications, and for other requirements; </font>
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        <div style=" margin-top:5.4pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:40pt;">
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          <font style="letter-spacing:0.2pt;">our estimates of the size and characteristics of the markets that may be addressed by our therapeutic candidates; </font>
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          <font style="letter-spacing:0.2pt;">market acceptance of our therapeutic candidates that are approved for marketing in the United States or other countries; </font>
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          <font style="letter-spacing:0.2pt;">our ability to successfully commercialize our therapeutic candidates, if approved for marketing; </font>
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        <div style=" margin-top:5.4pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:40pt;">
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          <font style="letter-spacing:0.2pt;">the safety and efficacy of therapeutics marketed by our competitors that are targeted to indications which our therapeutic candidates have been developed to treat; </font>
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        <div style=" margin-top:5.3pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:40pt;">
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          <font style="letter-spacing:0.2pt;">our ability to utilize our proprietary technological approach to develop and commercialize our therapeutic candidates; </font>
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          <font style="letter-spacing:0.2pt;">our heavy dependence on licensed intellectual property, including our ability to source and maintain licenses from third-party owners; </font>
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        <div style="text-align:center; width:456pt; line-height:12pt;">
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        <div style="width:456pt;">
          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
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        <div style="margin-top:3pt; width:456pt; line-height:13pt;">
          <font style="letter-spacing:0.2pt;">iv</font>
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      <div style="padding:0pt;margin:0pt;font-family:calibri, arial, sans-serif;font-weight:normal;font-style:normal;font-size:8pt;line-height:8pt;">
        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a>
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          <font style="letter-spacing:0.24pt;">Forward-Looking Statements</font>
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          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
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      <div style="margin-top:6pt;margin-bottom:262pt;margin-left:69.66pt;width:456pt;">
        <div style=" float:left; margin-left:20pt; line-height:12pt; text-align:left; width:20pt;white-space:nowrap;">
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          <font style="letter-spacing:0.2pt;">our ability to protect our own or in-licensed intellectual property and operate our business without infringing the intellectual property rights of others; </font>
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        <div style=" margin-top:6pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:40pt;">
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          <font style="letter-spacing:0.2pt;">our ability to attract, retain and motivate key personnel; </font>
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          <font style="letter-spacing:0.2pt;">our ability to generate revenue and become profitable; </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
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        <div style=" margin-top:6pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:40pt;">
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          <font style="letter-spacing:0.2pt;">the impact of natural disasters, global pandemics (including further outbreaks of existing strains of COVID-19 or new variants of the virus), armed conflicts and wars, labor disputes, lack of raw materials or other supplies, issues with facilities and equipment, or other forms of disruption to business operations at our manufacturing or laboratory facilities or those of our vendors; </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
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          <font style="font-family:Times New Roman, Times, serif;">&#10146;</font>
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        <div style=" margin-top:6pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:40pt;">
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          <font style="letter-spacing:0.2pt;">potential collaborations to license and commercialize any therapeutic candidates which receive regulatory approval in the future in or outside of the United States; and </font>
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          <font style="letter-spacing:0.2pt;">other risks and uncertainties, including those listed under the caption &#8220;Risk Factors&#8221; in our Annual Report on Form 10-K, our Quarterly Reports on Form 10-Q, and in our other regulatory filings. </font>
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          <font style="letter-spacing:0.2pt;">You should read this prospectus and the documents that we reference herein completely and with the understanding that our actual future results may be materially different from what we currently expect. You should assume that the information appearing in this prospectus and any document incorporated by reference is accurate as of its date only. Because the risk factors referred to above could cause actual results or outcomes to differ materially from those expressed in any forward-looking statements made by us or on our behalf, you should not place undue reliance on any forward-looking statements. Further, any forward-looking statement speaks only as of the date on which it is made, and we undertake no obligation to update any forward-looking statement to reflect events or circumstances after the date on which the statement is made or to reflect the occurrence of unanticipated events. New factors emerge from time to time, and it is not possible for us to predict which factors will arise. In addition, we cannot assess the impact of each factor on our business or the extent to which any factor, or combination of factors, may cause actual results to differ materially from those contained in any forward-looking statements. We qualify all of the information presented in this prospectus, any accompanying prospectus supplement and any document incorporated herein by reference, and particularly our forward-looking statements, by these cautionary statements.</font>
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          <font style="letter-spacing:0.2pt;">v</font>&#8203;</div>
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        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a><a name="tSUM">&#8203;</a>
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      <div style="border:1pt #000 solid;margin-top:27.85pt;min-height:694pt;margin-left:57.66pt;width:480pt;">
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          <div style="margin-top:0pt; text-align:center; width:456pt; line-height:20pt;font-weight:bold;font-size:18pt;">
            <font style="letter-spacing:-0.36pt;">Summary</font><font style="font-weight:normal;letter-spacing:0.36pt;"> </font>
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          <div style="margin-top:12pt; width:456pt; line-height:12pt;font-style:italic;">
            <font style="letter-spacing:0.2pt;">This summary highlights information contained elsewhere in this prospectus. This summary provides an overview of selected information and does not contain all of the information you should consider before investing in our securities. You should read the entire prospectus carefully, especially the &#8220;Risk Factors,&#8221; as well as &#8220;Management&#8217;s Discussion and Analysis of Financial Condition and Results of Operations&#8221; and our financial statements, including the accompanying notes to those statements, incorporated herein by reference to our Form&#160;10-K, our <a style="-sec-extract:exhibit" href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1829635/000155837024015731/rnaz-20240930x10q.htm">Quarterly Report on Form 10-Q filed with the SEC on November&#160;14, 2024</a>, and our other filings with the SEC before making an investment decision. If any of the risks materialize or other events or conditions arise that we cannot predict, our business, financial condition, operating results and prospects could be materially and adversely affected. As a result, the price of our common stock could decline, and you could lose part or all of your investment. Some of the statements in this prospectus and the documents incorporated herein by reference constitute forward-looking statements that involve risks and uncertainties. See &#8220;Cautionary Note Regarding Forward-Looking Statements.&#8221; Our actual results could differ materially from those anticipated in such forward-looking statements as a result of certain factors, including those discussed in &#8220;Risk Factors&#8221; and other sections of this prospectus and the documents incorporated herein by reference.</font><font style="font-style:normal;letter-spacing:0.2pt;"> </font>
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          <div style="margin-top:12pt; width:456pt; line-height:14pt;font-weight:bold;font-size:12pt;">
            <font style="letter-spacing:-0.24pt;">Overview</font><font style="font-weight:normal;letter-spacing:0.24pt;"> </font>
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            <font style="letter-spacing:0.2pt;">TransCode is clinical stage company with a platform delivery technology focused on oncology. TransCode was created on the belief that cancer can be defeated through the intelligent design and effective delivery of targeted therapeutics. Our lead therapeutic candidate, TTX-MC138 is currently being evaluated in a Phase&#160;I/II clinical study. TTX-MC138 targets microRNA-10b, or miRNA-10b, a master regulator of metastatic cell viability in a range of cancers, including breast, pancreatic, ovarian, colon cancer, glioblastomas, and several others. Metastatic disease is responsible for approximately 90% of cancer deaths and is the primary determinant in the life-limiting aspect of cancer. One validated driver of metastasis is miRNA-10b, a non-coding RNA associated with metastatic progression in numerous preclinical and more than 100 clinical studies. TransCode has developed a novel therapeutic agent (termed MN-anti-miR10b and being developed as TTX-MC138) that relies on specific eradication of metastatic tumor cells. TTX-MC138 consists of antagomirs against miRNA-10b conjugated to a unique delivery platform, called TTX, which is optimized for the targeting of primary and metastatic tumor cells. TransCode&#8217;s proprietary and patented technology is designed for the selective targeting of microRNA-10b in metastatic cells independent of their type or primary tumor origin. Numerous preclinical studies conducted by TransCode&#8217;s scientific co-founders have shown that TTX-MC138 mediates significant miR-10b inhibition </font><font style="font-style:italic;letter-spacing:0.2pt;">in vivo</font><font style="letter-spacing:0.2pt;">, eliciting a marked and durable regression of lymph node and distant metastases in mouse models of human breast cancer with no evidence of systemic toxicity. Specifically, as few as four to six weekly treatments with TTX-MC138 in combination with low dose chemotherapy led to complete regressions of detectable metastases. Of critical importance, following elimination of metastases and following discontinuation of therapy, no evidence was found to suggest recurrence over the remaining natural life span of the animals. In addition, similar studies in mouse models of pancreatic cancer were conducted with complete responses, defined as complete regression with no disease recurrence. Metastatic cancer represents a large unmet medical need; the global metastatic cancer treatment market is expected to reach $136.9&#160;billion by 2032 (PRNewswire/ July&#160;6, 2023 &#8212; Allied Market Research report, titled, &#8220;Metastatic Cancer Drugs Market&#8221;). </font>
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          <div style="margin-top:12pt; width:456pt; line-height:12pt;">
            <font style="letter-spacing:0.2pt;">On April&#160;14, 2024, we received an Investigational New Drug (IND) &#8220;Study May Proceed&#8221; letter from the U.S. Food and Drug Administration, or FDA, to conduct a Phase&#160;I/II clinical trial. The clinical trial is an open-label, multicenter study in cancer patients with advanced solid tumors. The objectives of this trial are to evaluate TTX-MC138 safety and tolerability of escalating dose levels of TTX-MC138. The objective of the dose-escalation stage of the trial is to determine the maximum tolerated dose, or MTD, of TTX-MC138 from which we anticipate selecting a recommended Phase&#160;2 dose, or RP2D, level. On September&#160;17, 2024, we announced the dosing of the first subject in the Phase&#160;I/II study. On October&#160;10, 2024, we announced completion of the first cohort of three patients in the Phase&#160;I clinical trial, and, on October&#160;23, 2024, we announced receipt of the trial&#8217;s Safety Review Committee&#8217;s authorization to proceed with dosing the second patient cohort. </font>
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          <font style="letter-spacing:0.2pt;">1</font>
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            <font style="letter-spacing:0.2pt;">Our pipeline includes a solid tumor program, TTX-siPDL1, an siRNA-based modulator of programmed death-ligand 1, or PD-L1 and TTX-RIGA, a cancer-agnostic program. TTX-RIGA is an RNA-based agonist of the retinoic acid-inducible gene I, or RIG-I, targeting activation of innate immunity in the tumor microenvironment. </font>
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            <font style="letter-spacing:0.2pt;">All our therapeutic candidates are designed to utilize our proprietary TTX delivery mechanism with the goal of significantly improving outcomes for cancer patients. Development of our pipeline candidates other than TTX-MC138 is on hold pending the availability of sufficient additional funding. </font>
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            <font style="letter-spacing:-0.24pt;">Recent Developments</font><font style="font-weight:normal;letter-spacing:0.24pt;"> </font>
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            <font style="letter-spacing:-0.2pt;">Restructuring</font><font style="font-style:normal;font-weight:normal;letter-spacing:0.2pt;"> </font>
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            <font style="letter-spacing:0.2pt;">Throughout 2024, we have continued the various actions approved by our board of directors in December&#160;2023 designed to streamline our operations and reduce expenses. These include delaying or eliminating certain development activities and reducing headcount by laying-off four employees in December&#160;2023 and not filling new vacancies. These actions lowered our headcount to 8 employees at September&#160;30, 2024, as compared to 19 employees on December&#160;31, 2022. We have narrowed our focus primarily to the continued execution of our Phase&#160;I/II clinical trial with TTX-MC138. </font>
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            <font style="letter-spacing:-0.2pt;">Phase&#160;0 Results</font><font style="font-style:normal;font-weight:normal;letter-spacing:0.2pt;"> </font>
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            <font style="letter-spacing:0.2pt;">On May&#160;29, 2024, we announced new preliminary data from our 2023 Phase&#160;0 clinical trial with radiolabeled TTX-MC138 suggesting anti-tumor activity. The new results from the patient dosed in the Phase&#160;0 clinical trial indicate that a microdose of radiolabeled TTX-MC138 resulted in significant inhibition of the drug candidate&#8217;s molecular target, miRNA-10b, in the patient&#8217;s blood. Specifically, after injection, the amount of miR-10b in the patient&#8217;s blood at 24 hours following dosing was approximately 66% lower than levels prior to administration of radiolabeled TTX-MC138. We believe these data support our belief that clinical development of TTX-MC138 has the potential for clinical benefit in patients with metastatic cancer. In addition, the Phase&#160;0 clinical trial also quantified the amount of drug candidate delivered to metastatic lesions, providing further evidence that TTX-MC138 accumulated in metastatic tumors. The increase of radioactive lesion-to-blood ratios suggests that circulating TTX-MC138 is actively taken up by the cancerous tissue. Overall, the microdose of radiolabeled TTX-MC138 was well tolerated with no adverse events observed. </font>
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            <font style="letter-spacing:-0.2pt;">Phase&#160;1 Clinical Trial</font><font style="font-style:normal;font-weight:normal;letter-spacing:0.2pt;"> </font>
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            <font style="letter-spacing:0.2pt;">Our Phase&#160;I/II clinical trial with our lead therapeutic candidate, TTX-MC138, is a multicenter, open-label, dose-escalation and dose-expansion study in patients with advanced solid tumors. We commenced the trial in the third quarter 2024 at MD Anderson Cancer Center and three other clinical trial sites. The first stage of this trial, the Phase&#160;1a, calls for administration of increasing therapeutic dose levels of our drug candidate in an adaptive design to as many as six cohorts of a small number of patients per cohort. The first cohort is receiving the lowest therapeutic dose level. In October&#160;2024, after assessing results from the initial dosing of the patients in the first cohort of the trial, the trial&#8217;s Safety Review Committee, or SRC, approved commencing dosing of patients in the second cohort. Patients in the second cohort are receiving a dose that is double the level received by patients in the first cohort. After 28&#160;days following their initial dosing, the SRC will assess results from patients in the second cohort to determine if there were any adverse effects or dose limiting toxicities. If none are reported, we anticipate receiving approval to commence dosing the third cohort at a dosage that is double that administered in the second cohort. </font>
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            <font style="letter-spacing:-0.2pt;">November&#160;2024 Financing</font><font style="font-style:normal;font-weight:normal;letter-spacing:0.2pt;"> </font>
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            <font style="letter-spacing:0.2pt;">On November&#160;26, 2024, we signed stock purchase agreements with certain investors in a private placement of our securities. The offering price per unit was $0.377, for gross proceeds of approximately $8,000,000, </font>
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          <font style="letter-spacing:0.2pt;">2</font>
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            <font style="letter-spacing:0.2pt;">before deducting placement agent fees and other offering expenses. The offering was made pursuant to an exemption from registration of the securities. </font>
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            <font style="letter-spacing:-0.2pt;">NIH SBIR Award</font><font style="font-style:normal;font-weight:normal;letter-spacing:0.2pt;"> </font>
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            <font style="letter-spacing:0.2pt;">In September&#160;2024, we received our second NIH Award, or the 2024 Award, a Direct to Phase&#160;II SBIR Award, from the National Cancer Institute of the NIH. The 2024 Award is to support IND-enabling and clinical trial activities in our Phase1a clinical trial with our lead candidate, TTX-MC138, over two&#160;years. The total Award is for $1,999,972 of which $1,011,207 applies to the first year and $988,765 applies to the second year. </font>
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            <font style="letter-spacing:-0.2pt;">Oncotarget Publication</font><font style="font-style:normal;font-weight:normal;letter-spacing:0.2pt;"> </font>
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            <font style="letter-spacing:0.2pt;">In September&#160;2024, we reported the August&#160;26, 2024, publication of an article in the journal </font><font style="font-style:italic;letter-spacing:0.2pt;">Oncotarget</font><font style="letter-spacing:0.2pt;"> titled, </font><font style=" text-decoration:underline #000000 solid;font-style:italic;letter-spacing:0.2pt;">Inhibition of miR-10b treats metastatic breast cancer by targeting stem cell-like properties</font><font style="letter-spacing:0.2pt;"> conducted in collaboration with Michigan State University. The study was led by Dr.&#160;Anna Moore, Professor, Director of the Precision Health Program, and Associate Dean of the School of Medicine at Michigan State University and our scientific co-founder. In this study, the authors show that stem-like breast cancer cells increase expression of miR-10b, the molecule targeted by TTX-MC138. The study also demonstrates that treatment of breast cancer cells with TTX-MC138 reduces their stemness, confirming that these properties make metastatic cells susceptible to the therapeutic candidate&#8217;s actions. Cancer cell stemness, or capacity for self-renewal, is a critical component of metastasis, since specialized cancer stem cells are those cells uniquely capable of creating new tumors and seeding metastatic dissemination. Stemness is a property of a distinct population of cancer cells that possess developmental plasticity allowing them to self-renew and adapt to new microenvironments found at the metastatic organ where they lead to creation of metastatic tumors. </font>
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            <font style="letter-spacing:-0.2pt;">Potential Nasdaq Delisting</font><font style="font-style:normal;font-weight:normal;letter-spacing:0.2pt;"> </font>
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            <font style="letter-spacing:0.2pt;">In the third quarter 2024, we received three letters from the staff of the Nasdaq Stock Market (&#8220;Nasdaq&#8221;) notifying us that we were not in compliance with Nasdaq Listing Rules 5550(a)(2) (the &#8220;Bid Price Rule&#8221;); 5550(b)(1) (the &#8220;Equity Rule&#8221;) or any of the alternative requirements in Listing Rule&#160;5550(b); and 5635(d) (the &#8220;Shareholder Approval Rule&#8221;). As a result, shares of our common stock are subject to delisting from trading on The Nasdaq Capital Market. On October&#160;1, 2024, we appealed the Staff&#8217;s determination to a Nasdaq Hearings Panel (the &#8220;Panel&#8221;). On November&#160;4, 2024, we were notified that the Panel granted us an extension until December&#160;31, 2024, to regain compliance with the Nasdaq Listing Rules. </font>
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            <font style="letter-spacing:0.2pt;">In order to regain compliance with the Nasdaq Listing Rules, we must, (i)&#160;on or before November&#160;22, 2024, obtain shareholder approval for a reverse stock split in a ratio sufficient to regain compliance with the Bid Price Rule (we obtained this approval on November&#160;22, 2024); (ii)&#160;on or before November&#160;22, 2024, obtain shareholder ratification of the equity offering we completed in July&#160;2024 (the &#8220;July Offering&#8221;) (we obtained this approval on November&#160;22, 2024); (iii)&#160;on or before December&#160;31, 2024, demonstrate compliance with the Bid Price Rule; (iv)&#160;on or before December&#160;31, 2024, have filed a public disclosure describing the transactions we undertook to achieve compliance and demonstrate long-term compliance with the Equity Rule and provide an indication of our equity following those transactions; and (v)&#160;on or before December&#160;31, 2024, have provided the Panel with income projections for the next twelve&#160;months, with all underlying assumptions clearly stated and evidence of compliance with all other applicable criteria for continued listing on the Nasdaq Capital Market. </font>
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            <font style="letter-spacing:0.2pt;">As of December 6, 2024, we believe we have fulfilled the NASDAQ requirements listed in (i)&#160;and (ii)&#160;above, and are diligently working on timely fulfilling all remaining requirements. However, there is no assurance that we will successfully regain compliance with Nasdaq Listing Rules. </font>
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            <font style="letter-spacing:0.2pt;">In the event of a delisting from the Nasdaq Capital Market, we may seek to have our stock traded in the over-the-counter inter-dealer quotation system, more commonly known as the OTC. OTC transactions involve risks in addition to those associated with transactions in securities traded on the securities exchanges, such as </font>
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          <font style="letter-spacing:0.2pt;">3</font>
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            <font style="letter-spacing:0.2pt;">the Nasdaq Capital Market, or, together, Exchange-listed stocks. Many OTC stocks trade less frequently and in smaller volumes than Exchange-listed stocks. Accordingly, our stock would be less liquid than it would be otherwise. Also, the prices of OTC stocks are often more volatile than Exchange-listed stocks. Additionally, institutional investors are usually prohibited from investing in OTC stocks, and it might be more challenging to raise capital. In light of our financial position and our need to raise additional capital, delisting of our common stock from the Nasdaq Capital Market would materially limit our ability to obtain additional equity capital. We may need to seek an in-court or out-of-court restructuring of our liabilities. In the event of such restructuring activities, holders of our common stock and other securities will likely suffer a total loss of their investment. </font>
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            <font style="letter-spacing:-0.2pt;">Reverse Stock Split</font><font style="font-style:normal;font-weight:normal;letter-spacing:0.2pt;"> </font>
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            <font style="letter-spacing:0.2pt;">On December&#160;4, 2024, we effected a 1-for-33 reverse stock split of our outstanding common stock, shares either issued and outstanding or shares we hold as treasury stock. The December&#160;2024 Reverse Split did not change the number of authorized shares of common stock. </font>
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            <font style="letter-spacing:0.2pt;">All common stock share and per share data, and exercise price data for applicable common stock equivalents, included in this prospectus, except those in our financial statements and documents incorporated by reference dated prior to the December&#160;2024 Reverse Split, have been retroactively adjusted to reflect the December&#160;2024 Reverse Split. Any fractional shares resulting from the December&#160;2024 Reverse Split have been rounded up to the nearest whole share. </font>
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            <font style="letter-spacing:-0.24pt;">Targeted Therapeutic Delivery Background</font><font style="font-weight:normal;letter-spacing:0.24pt;"> </font>
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          <div style="margin-top:12pt; width:456pt; line-height:12pt;">
            <font style="letter-spacing:0.2pt;">For decades, ribonucleic acid, or RNA, has been a topic of investigation by the scientific community as a potentially attractive therapeutic modality because it can target any gene and it lends itself to rational and straightforward drug design. RNA-based therapeutics are highly selective to their targets, potentially applicable to a broad array of previously undruggable targets in the human genome. We believe that one of the major challenges to widespread use of RNA therapeutics in oncology and other indications has been the inability to deliver these molecules inside cells other than in the liver. </font>
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            <font style="letter-spacing:0.2pt;">We believe that our proprietary TTX delivery platform has the potential to resolve these key challenges. We believe overcoming the challenges of delivery would represent an important step in unlocking therapeutic access to a variety of documented targets involved in a range of cancers and other diseases. </font>
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            <font style="letter-spacing:0.2pt;">TransCode has created a design engine to customize the development of targeted therapeutics that is modular, both at the levels of the core nanoparticle and therapeutic loading. The size, charge, and surface chemistry of the core iron oxide nanoparticle is designed so that it can be tuned to optimize the particles for the intended target and therapeutic load. The therapeutic load is designed to consist of synthetic oligonucleotides and other molecular moieties that can be adapted to the specific approach being developed. The approach can range from RNA interference, or RNAi, including small interfering RNAs, antisense oligonucleotides, and Pattern Recognition Receptor agonists such as RIG-I. While we have explored approaches to delivery of CRISPR and mRNAs using TTX, we have not yet established feasibility. We believe the platform can further be used for developing targeted radiolabeled therapeutics and diagnostics and other custom products targeting known and novel biomarkers and other genetic elements as they are discovered and validated. </font>
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            <font style="letter-spacing:0.2pt;">The TTX platform is designed to overcome extracellular and intracellular delivery issues of stability, efficiency, and immunogenicity faced by existing lipid and liposomal nanoparticle platforms while optimizing targeting of and accumulation in tumors and metastases. We believe the ability to deliver targeted therapeutics inside tumors and metastases will potentially allow us to target genes and other important biomarkers for cancer treatment that have until now remained undruggable using other delivery systems. </font>
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          <font style="letter-spacing:0.2pt;">4</font>
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            <font style="letter-spacing:-0.24pt;">Potential Near-term Milestones</font><font style="font-weight:normal;letter-spacing:0.24pt;"> </font>
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            <font style="letter-spacing:0.2pt;">We have enrolled patients in our second cohort in our Phase&#160;I/II clinical trial and are awaiting the Safety Review Committee&#8217;s assessment to determine if we may begin dosing patients in the third cohort. Our outsourced drug manufacturing partner completed the manufacture of a GMP drug product batch for the ongoing Phase&#160;I clinical trial. </font>
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            <font style="letter-spacing:0.2pt;">Subject to available capital, we plan to complete the stage 1a portion of our Phase&#160;I/II clinical trial upon meeting the required adaptive study design approved by the FDA, anticipated to be not later than the second quarter of 2026. </font>
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            <font style="letter-spacing:0.2pt;">Complete the final clinical trial report for our Phase&#160;0 clinical trial. </font>
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            <font style="letter-spacing:0.2pt;">We have ongoing discussions with strategic partners involving a variety of our therapeutic candidates and hope to complete a partnering agreement with respect to one or more therapeutic candidates as soon as practical. We currently have no firm commitments from any strategic partners and there is no assurance that any partnering transactions will be effected. </font>
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            <font style="letter-spacing:0.2pt;">If capital is available, we may advance development of one or more of our preclinical assets, including manufacturing activities to support IND enabling studies. If commenced, these activities would involve approximately two&#160;years as the drug candidate(s) would represent new molecular entities. </font>
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            <font style="letter-spacing:0.2pt;">We previously obtained FDA Orphan Drug Designation and may file for European Orphan Drug Designation for TTX-MC138 in pancreatic cancer. </font>
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            <font style="letter-spacing:-0.24pt;">Delivery System</font><font style="font-weight:normal;letter-spacing:0.24pt;"> </font>
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            <font style="letter-spacing:0.2pt;">The therapeutic potential of RNA in oncology has remained an unrealized promise due in large part, we believe, to the difficulty in safely and effectively delivering oligonucleotides, i.e., synthetic RNA molecules, to tumors. We believe we are now closer to solving this challenge by means of our TTX platform. Our TTX platform leverages an iron-oxide nanoparticle, or IONP, approved for clinical use as a cancer imaging agent and in treating iron deficiency anemia, as the physical carrier. </font>
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            <font style="letter-spacing:0.2pt;">The TTX technology has gone through approximately 20&#160;years of research and development, or R&amp;D, and optimization, including 12&#160;years at Harvard Medical School and the Massachusetts General Hospital, by our scientific co-founders prior to company formation. </font>
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          <div style="margin-top:12pt; width:456pt; line-height:12pt;">
            <font style="letter-spacing:0.2pt;">Our TTX nanocarrier is designed to be tunable to pre-designed specifications to deliver therapeutic oligonucleotides to RNA targets in tumors and metastases without compromising the integrity of the oligonucleotide. We believe TTX nanocarriers differentiate us from competitive delivery approaches, many of which rely on lipid particles or chemical structures, such as GalNAc. These competitive delivery approaches effectively target sites in the liver but not sites in tumors and metastases elsewhere. Our delivery technology could allow us to participate in additional rapidly growing global marketplaces. </font>
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            <font style="letter-spacing:0.2pt;">Our TTX delivery platform is specifically designed to minimize early kidney and liver clearance, translating into a long circulation half-life that allows for efficient accumulation in tumors and metastases. Nanoparticles similar in formulation to ours have an excellent clinical safety record of low toxicity and immunogenicity, and their built-in imaging capabilities due to their iron core which is magnetic and visible with magnetic resonance imaging, or MRI, have the additional benefit of enabling quantification of the particles&#8217; delivery to target organs. The nanoparticles may be functionalized with amino or other functional groups to provide stable links to the therapeutic oligonucleotides of interest through covalent bonds. The TTX chemistry can be modified with various coatings to stabilize the nanoparticles, protect the cargo from degradation, promote tumor uptake and entrapment of the drug candidate inside tumor cells, and </font>
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          <font style="letter-spacing:0.2pt;">5</font>
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            <font style="letter-spacing:0.2pt;">allow control over drug pharmacokinetics. The nanoparticle used with our lead candidate, TTX-MC138, is coated with dextran, a glucose polymer, to protect the oligonucleotides from degradation and to provide overall stability to the particle. </font>
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            <font style="letter-spacing:0.2pt;">The small hydrodynamic size and the charge of the resulting nanoparticles are designed to maximize distribution throughout the tumor microvasculature, extravasation into the interstitium of tumors and metastases, and uptake by tumors. The physicochemical properties of the nanoparticles are expected to further facilitate their rapid uptake by tumors by exploiting the high metabolic activity of cancer cells, a process analogous to the mechanism behind the systemic loading of metastatic cancer cells with fluorodeoxyglucose for diagnostic Positron Emission Tomography. We believe the combined result of a hydrodynamically-favored distribution and a metabolically-triggered uptake will result in the enhanced ability of our nanoparticles to access genetic targets inside tumors. </font>
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            <font style="letter-spacing:-0.24pt;">Advancing new RNA therapies through a modular approach</font><font style="font-weight:normal;letter-spacing:0.24pt;"> </font>
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            <font style="letter-spacing:0.2pt;">The TransCode TTX platform is modular by design, both at the level of the core nanoparticle and at the therapeutic loading. The size, charge, and surface chemistry of the core nanoparticles can be tuned to optimize them for the intended target and therapeutic load. Also, the therapeutic load can be adapted to the specific approach being developed, ranging from RNA interference, or RNAi, which includes small interfering RNAs, or siRNAs, antisense oligonucleotides, as well as Pattern Recognition Receptor agonists such as retinoic acid inducible gene, or RIG-I. In addition to nucleic acids, the TTX platform could be used to also deliver proteins, peptides, radionuclides and small molecules. </font>
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            <font style="letter-spacing:0.2pt;">Additionally, we are interested in pursuing diagnostic approaches for RNA targets that might be relevant and important to informing treatment of patients using RNA therapeutics. Our 2018 license with MGH includes a patented microRNA screening assay with the potential to detect expression of microRNAs in patient blood. Depending on available capital, we may seek to optimize this diagnostic test to detect miR-10b in cancer patients as our first commercial testing product. If approved, this test could be used as a screening assay to detect metastasis in a variety of tumor types. Also, we believe we may be able to use this test to evaluate miR-10b expression before, during and after treatment to best determine timing of therapeutic intervention. </font>
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            <font style="letter-spacing:0.2pt;">In September&#160;2021, research conducted by MGH was published in Cancer Nanotechnology, entitled &#8220;Radiolabeling and PET-MRI microdosing of the experimental cancer therapeutic, MN-anti-miR10b, demonstrates delivery to metastatic lesions in a murine model of metastatic breast cancer.&#8221; This paper reported on an MGH study using a radiolabeled derivative of TTX-MC138 (referred to in the paper as MN-anti-miR10b). In this study, TTX-MC138 was tagged with copper-64, or Cu-64. As a result, highly sensitive and specific quantitative determination of pharmacokinetics and biodistribution, as well as observation of delivery of the Cu-64 labeled TTX-MC138 to metastases, was made in laboratory tests using noninvasive positron emission tomography-magnetic resonance imaging, or PET-MRI. The key results of the study suggest that TTX-MC138, when injected intravenously, accumulates in metastatic lesions. These results suggest that our TTX platform delivers its therapeutic candidate as intended and supports clinical evaluation of TTX-MC138. In addition, the MGH investigation describes a microdosing PET-MRI approach to measure TTX-MC138 biodistribution in cancer patients and its delivery to clinical metastases. (Microdoses are minute, subpharmacologic doses of a test compound, not greater than 100 micrograms.) The capacity to carry out microdosing PET-MRI studies in patients under an exploratory IND, or eIND, application could be important because it has the potential to facilitate FDA authorization of additional human studies. This research, published by Dr.&#160;Zdravka Medarova, our Chief Technology Officer and scientific co-founder, and others describes what we believe is an effective approach to assessing delivery of TTX-MC138 in metastatic cancer patients. Since the PET-MRI technique is sensitive enough to determine the concentration of radiolabeled drug candidate in the sub-picomolar range, microgram quantities of the radiolabeled drug candidate are believed to be sufficient to perform such a study in humans. We believe this capability has significant advantages in the initial phases of drug development. Because the low mass of the radiolabeled drug candidate does not induce reactions in humans, we believe the regulatory process is less complex. </font>
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          <font style="letter-spacing:0.2pt;">6</font>
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            <font style="letter-spacing:0.2pt;">Dr.&#160;Medarova&#8217;s paper suggests that the radiolabeling does not impact tumor cell uptake or the ability of TTX-MC138 to engage its target. The paper also shows that the biodistribution of Cu-64 labeled TTX-MC138, when injected at a microdose, reflects its biodistribution at the level of a therapeutic dose. </font>
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            <font style="letter-spacing:0.2pt;">These key findings informed our microdosing clinical trial with TTX-MC138. We believed that our microdosing trial had numerous advantages: </font>
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            <font style="letter-spacing:0.2pt;">(i)</font>
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            <font style="letter-spacing:0.2pt;">allowing more precise quantitation of the amount of TTX-MC138 delivered to the metastatic lesions because of the higher sensitivity and quantitative accuracy of positron emission tomography; </font>
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          <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
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            <font style="letter-spacing:0.2pt;">(ii)</font>
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            <font style="letter-spacing:0.2pt;">permitting measurement of the pharmacokinetics and biodistribution of TTX-MC138 not only in the metastatic lesions but in other tissues throughout the body. This knowledge can inform Phase&#160;I/II clinical trial designs by allowing us to determine drug candidate uptake and clearance from vital organs; </font>
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            <font style="letter-spacing:0.2pt;">enabling measurement of pharmacokinetic endpoints potentially informing dosing for Phase&#160;II/III clinical trials. Specifically, because of the high sensitivity and quantitative nature of PET-MRI, it may be possible to derive a more precise calculation of drug concentration in the metastatic lesions over time and then correlate that information to the effective dose defined in our preclinical studies; and </font>
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            <font style="letter-spacing:0.2pt;">(iv)</font>
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            <font style="letter-spacing:0.2pt;">further informing selection of indications for Phase&#160;II/III trials by allowing trial design based on which patients&#8217; metastases demonstrated accumulation of TTX-MC138 in prior trials. </font>
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            <font style="letter-spacing:0.2pt;">Because of the benefits we believe derived from a microdosing Phase&#160;0 trial, and reflecting the studies described in Cancer Nanotechnology, we pursued a microdosing Phase&#160;0 trial for our First-in-Human clinical trial conducted at MGH. </font>
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            <font style="letter-spacing:0.2pt;">We believe that results from the Phase&#160;0 trial also validated delivery generally for our TTX pipeline which potentially opens-up additional relevant RNA targets that have been previously undruggable. </font>
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            <font style="letter-spacing:0.2pt;">In the Phase&#160;0 trial, we administered a single microdose of radiolabeled TTX-MC138 to the trial patient, with delivery of TTX-MC138 to metastatic lesions and other tissues evaluated by PET-MRI. </font>
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            <font style="letter-spacing:-0.24pt;">Our Lead Therapeutic Candidate</font><font style="font-weight:normal;letter-spacing:0.24pt;"> </font>
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            <font style="letter-spacing:0.2pt;">Our scientific co-founders developed our lead therapeutic candidate while at The General Hospital Corporation, d/b/a Massachusetts General Hospital, to target microRNA-10b, a well-validated biomarker linked to metastatic cancer. In contrast, most anti-cancer therapies target primary tumors and do not address metastatic disease specifically. MicroRNA-10b has been shown to be the master regulator of metastatic disease in multiple tumor types. We believe effective therapeutics have not been developed targeting microRNA-10b because of challenges in delivering therapeutics to tumors despite microRNA-10b&#8217;s strong association with cancer metastasis as documented in over 700 peer-reviewed scientific publications. </font>
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            <font style="letter-spacing:0.2pt;">TTX-MC138 comprises proprietary iron-oxide nanoparticles conjugated to sequence-specific LNA/DNA oligonucleotides that target microRNA-10b. The nanoparticles serve as a vehicle to deliver oligonucleotides to tumors and metastases. The magnetic properties of these nanoparticles allow for monitoring their delivery using non-invasive imaging, which we believe adds value for clinical implementation of this therapeutic approach. </font>
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            <font style=" text-decoration:underline #000000 solid;letter-spacing:0.2pt;">Preclinical Study Results&#8201;&#8212;&#8201;Breast Cancer</font><font style="font-style:normal;letter-spacing:0.2pt;"> </font>
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            <font style="letter-spacing:0.2pt;">Our scientific co-founders conducted a variety of preclinical animal studies involving human metastatic breast cancer models. In these studies, TTX-MC138 was successfully delivered to metastatic lesions in the lymph nodes, lungs, and bones as shown by non-invasive imaging performed 24 hours after injection. In five </font>
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            <font style="letter-spacing:0.2pt;">separate studies involving over 125 mice, TTX-MC138 was injected into mice implanted with human metastatic breast tumors. These mouse models included the rodent 4T1-luc2 orthotopic allograft, which is a very aggressive model of stage IV metastatic breast cancer, the human MDA-MB-231-luc-D3H2LN xenograft, which is a stage II/III cancer model, and the human MDA-MB-231-BrM2-831 xenograft, which is a model of breast cancer metastatic to the brain. Tumors in mice implanted with MDA-MB-231 cells typically progress from localized disease to lymph node metastases within 21&#160;days of implantation. Tumors in mice implanted with 4T1-luc2 cells typically progress to distant sites in the animals within 10&#160;days of implantation. </font>
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            <font style="letter-spacing:0.2pt;">To test TTX-MC138 in the model of lymph node metastatic breast cancer, mice had their primary tumors surgically removed four to five weeks after tumor inoculation, following confirmation of lymph node metastases via imaging. This was done to better simulate a clinical scenario, since the current standard of care involves surgical removal of the primary tumor in patients with lymph node metastatic breast cancer. Treatment with TTX-MC138 was then initiated during the week of tumor removal. Because tumors in mice replicate more rapidly than is typical in humans, we combined low-dose doxorubicin with the TTX-MC138 because doxorubicin slows metastatic cell replication specific to these tumor models. Doing so allowed the TTX-MC138 to more efficiently reach and inhibit the miR-10b inside the tumor cells. </font>
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            <font style="letter-spacing:0.2pt;">After four weeks of therapy, metastases in mice treated with TTX-MC138 regressed. By contrast, in the control groups, there was metastatic progression (Within-Subjects ANOVA: p &lt; 0.05). Treatment was discontinued once complete metastatic regression was observed. By the end of the study at 12 weeks, there was no recurrence and 100% survival in treated subjects having this cancer model. In similar studies involving mice implanted with 4T1-luc2 breast tumors, we observed regression of distant metastases by week six, at which point treatment was stopped (Within-Subjects ANOVA: p &lt; 0.05). Despite stopping treatment, the animals remained metastasis-free and by the end of the study, no recurrence of disease had been observed. There was evidence of complete regression without recurrence in 65% of treated subjects while 35% progressed due to insufficient inhibition of miR-10b in this group. We believe this was due to the high rate of tumor cell replication in this model resulting in dilution of the therapeutic. We do not expect this to be the case in humans with metastatic disease, in whom tumor cell replication is dramatically slower than in mice. </font>
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            <font style=" text-decoration:underline #000000 solid;letter-spacing:0.2pt;">Preclinical Study Results&#8201;&#8212;&#8201;Pancreatic Cancer</font><font style="font-style:normal;letter-spacing:0.2pt;"> </font>
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            <font style="letter-spacing:0.2pt;">We evaluated the efficacy of TTX-MC138 as monotherapy in a murine model of pancreatic adenocarcinoma and achieved positive preclinical results. In this study, we treated mice bearing human pancreatic tumors with TTX-MC138 once weekly for eight weeks. The drug candidate demonstrated a pharmacodynamic response by successfully inhibiting miR-10b. Serum miR-10b was down-regulated by TTX-MC138 and was shown to be a potential surrogate biomarker of therapeutic efficacy, opening up the possibility of noninvasive monitoring of therapeutic response in human patients. Forty&#160;percent (40%) of animals treated with TTX-MC138 had complete responses, defined as complete regression of disease and long-term survival without recurrence. </font>
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            <font style="letter-spacing:0.2pt;">These new findings expand the potential therapeutic relevance of TTX-MC138 beyond breast cancer, in which activity had previously been shown in preclinical studies, to include pancreatic adenocarcinoma. However, there is no assurance that these preclinical results will be duplicated in further preclinical studies or in cancer patients suffering from pancreatic cancer. </font>
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            <font style=" text-decoration:underline #000000 solid;letter-spacing:0.2pt;">Preclinical Study Results&#8201;&#8212;&#8201;Glioblastoma</font><font style="font-style:normal;letter-spacing:0.2pt;"> </font>
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            <font style="letter-spacing:0.2pt;">Studies have shown that miR-10b is highly expressed in high-grade glioblastoma multiforme, or GBM, and its inhibition leads to dysregulation of multiple pathways in tumorigenesis, resulting in repression of tumor growth and increased apoptosis. Thus, we hypothesized that suppressing miR-10b could enhance the cytotoxicity of conventional GBM chemotherapy with temozolomide, or TMZ. Inhibition of miR-10b in glioblastoma cells was achieved using MN-anti-miR10b (a TTX-MC138 analogue). Treatment of U251 </font>
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            <font style="letter-spacing:0.2pt;">and LN229 human glioblastoma cells with our drug candidate led to inhibition of miR-10b accompanied by repression of growth and increase in apoptosis. We next explored whether MN-anti-miR10b could enhance the cytotoxic effect of TMZ. During these studies, we unexpectedly found that TMZ monotherapy increased miR-10b expression and changed the expression of corresponding miR-10b targets. This discovery led to the design of a sequence-dependent combination treatment, in which miR-10b inhibition and induction of apoptosis by MN-anti-miR10b was followed by a sub-therapeutic dose of TMZ, which caused cell cycle arrest and ultimately tumor cell death. Additionally, studies in human patient-derived models of GBM confirmed delivery to the brain tumors and exhibited a highly significant level of target inhibition, indicating robust pharmacodynamic activity. </font>
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            <font style=" text-decoration:underline #000000 solid;letter-spacing:0.2pt;">Ongoing and Planned Clinical Trials</font><font style="font-style:normal;letter-spacing:0.2pt;"> </font>
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            <font style="letter-spacing:0.2pt;">In 2023, we conducted a First-in-Human, or FIH, clinical trial with TTX-MC138-NODAGA-Cu64 (a radiolabeled version of TTX-MC138). This clinical trial involved administering a single microdose of TTX-MC138-NODAGA-Cu64 into cancer patients with advanced solid tumors. Dosing was followed by imaging using integrated positron emission tomography-magnetic resonance imaging, or PET-MRI. The Phase&#160;0 trial was intended to quantify the amount of radiolabeled TTX-MC138 delivered to metastatic lesions and the pharmacokinetics (PK) and biodistribution of the therapeutic candidate in cancer patients. The single microdose design of the Phase&#160;0 trial was not expected to demonstrate target engagement. The Phase&#160;0 trial yielded critical data regarding therapeutic dose, timing, and potential safety that may inform later clinical trials. We believe that demonstrating our ability to overcome the challenge of RNA delivery to genetic targets, and specifically to tumors and metastases, represents a major step forward in unlocking therapeutic access to genetic targets involved in a range of cancers. We announced preliminary Phase&#160;0 data in the fourth quarter 2023, and additional results in May&#160;2024. In the third quarter 2024, we commenced our Phase&#160;I/II clinical trial. Our Phase&#160;I/II clinical trial is an open-label, multicenter dose escalation and dose expansion study to evaluate TTX-MC138 safety and tolerability of escalating dose levels of TTX-MC138. The objective of the dose-escalation stage of the trial is to determine the maximum tolerated dose, or MTD, from which we anticipate, determining a recommended Phase&#160;II dose, or RP2D. On September&#160;17, 2024, we announced dosing of the first patient in the Phase&#160;I/II clinical trial. On October&#160;10, 2024, we announced completion of the initial dosing of the first patients in this trial (designated as cohort 1) and, on October&#160;23, 2024, we announced Safety Review Committee authorization to proceed with dosing patients comprising cohort 2. </font>
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            <font style="letter-spacing:-0.24pt;">Modular Design Toolbox</font><font style="font-weight:normal;letter-spacing:0.24pt;"> </font>
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            <font style="letter-spacing:0.2pt;">We employ a design engine to enable development of RNA therapeutic candidates that we believe can be efficiently delivered to genetic targets inside tumor cells. This approach is based on four complementary elements that together address the challenges of RNA drug development in oncology: </font>
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            <font style="font-weight:bold;letter-spacing:-0.2pt;">Nanocarrier Delivery Mechanism &#8212;</font><font style="letter-spacing:0.2pt;"> Our strategy seeks to leverage a nanoparticle that has been extensively used in humans for imaging by repurposing it to deliver targeted therapeutics to oncology targets and for other therapeutic applications. The nanocarrier is tunable to pre-designed specifications to deliver therapeutic oligonucleotides to an RNA target in tumors and metastases without compromising its integrity. These nanocarriers differentiate us from competitive delivery approaches, many of which rely on lipid nanoparticles or chemical structures, such as GalNAc. Competitive delivery approaches effectively target sites in the liver but not sites in tumors and metastases elsewhere. </font>
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            <font style="letter-spacing:0.2pt;">We expect that our competitive advantages will include effectively reaching tumors and metastases, achieving robust target engagement in tumor cells, which may result in a wide therapeutic window . </font>
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            <font style="font-weight:bold;letter-spacing:-0.2pt;">Genetic Code &#8212;</font><font style="letter-spacing:0.2pt;"> Our approach to drug development takes advantage of our rapidly expanding knowledge about the human genome and the annotation of the genome&#8201;&#8212;&#8201;the knowledge about what different genes are responsible for, especially in cancer. Armed with this knowledge, we can take advantage of the coded </font>
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            <font style="letter-spacing:0.2pt;">nature of the genome to design therapeutic or diagnostic agents. Specifically, once we determine the code of the cancer target, we can develop therapeutic candidates using specific nucleic acids that are harmonized to that target and potentially rewrite the story on cancer. This is what TransCode means&#8201;&#8212;&#8201;to change the code. After determining the genetic target of interest, we may be able to choose from a variety of RNA approaches best suited for that target. Those approaches will likely range from RNAi, which include siRNAs, antisense oligonucleotides, and non-coding RNA mimics, or Pattern Recognition Receptor agonists like RIG-I. </font>
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            <font style="font-weight:bold;letter-spacing:-0.2pt;">Modular Design for Therapeutic Development &#8212;</font><font style="letter-spacing:0.2pt;"> Our discovery platform consists of a modular &#8216;toolbox&#8217; for developing therapeutic candidates designed to attack specific disease-causing RNA targets based on the phenomenon of genetic complementarity. These therapeutic candidates incorporate synthetic oligonucleotides, or oligos, that can be designed as antagomirs, mimics, miRNA sponges, siRNA duplexes, ribozymes, and others depending on the desired therapeutic strategy. In addition to the varied oligo design approach, we can also synthesize nanocarriers with tunable chemistry properties to enable delivery of proteins, peptides, radionuclides and small molecules. Combined, the modularity and tunability of these oligonucleotides and nanocarrier components may enable the potential to synthesize libraries of therapeutic agents designed for a given indication or a given patient in terms of therapeutic oligonucleotide design, size, surface coating and charge, hydrophilicity and hydrophobicity, and antigen-targeting through incorporation of targeting peptides. </font>
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            <font style="font-weight:bold;letter-spacing:-0.2pt;">Image Guided &#8212;</font><font style="letter-spacing:0.2pt;"> Because our therapeutic candidates are innately detectable using non-invasive imaging, we can monitor their delivery to the tissue of interest and measure their bioavailability. The ability to monitor delivery using Magnetic Resonance Imaging, or MRI, can be instrumental in assessing and controlling the amount of oligonucleotide that reaches targeted tissues. MRI use during the design phase of the therapeutic candidate could guide drug design, delivery schedule, route, and dose and could suggest alternatives should treatment with the therapeutic candidate fail in a given patient. This is critical during drug development because it should allow us to optimize drug design to maximize therapeutic effect. </font>
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            <font style="letter-spacing:-0.24pt;">Pipeline</font><font style="font-weight:normal;letter-spacing:0.24pt;"> </font>
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            <font style="letter-spacing:-0.24pt;">Summary of Risks</font><font style="font-weight:normal;letter-spacing:0.24pt;"> </font>
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            <font style="letter-spacing:0.2pt;">Our business is subject to numerous material and other risks and uncertainties that you should be aware of in evaluating our business. These risks are described more fully elsewhere in this prospectus or incorporated herein by reference, including in the section entitled &#8220;Risk Factors,&#8221; and our other filings with the SEC and include, but are not limited to, the following: </font>
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            <font style="letter-spacing:0.2pt;">our low cash position and our estimates and expectations regarding our capital requirements, cash and expense levels, liquidity sources and our ability to obtain, on satisfactory terms or at all, the financing required to support operations, research, development, clinical trials, and commercialization of products; </font>
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            <font style="letter-spacing:0.2pt;">a potential delisting of our common stock from trading on the Nasdaq Capital Market because we have not met certain Nasdaq listing requirements; </font>
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            <font style="letter-spacing:0.2pt;">our ability to continue as a going concern; </font>
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            <font style="letter-spacing:0.2pt;">our business is highly dependent on the success of TTX-MC138, our lead therapeutic candidate which is at the early stages of development. Our therapeutic candidates require significant additional preclinical, clinical development and manufacturing validation before we may be able to seek regulatory approval for and launch a product commercially; </font>
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            <font style="letter-spacing:0.2pt;">the results from our manufacturing, preclinical and clinical trial activities; </font>
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            <font style="letter-spacing:0.2pt;">the therapeutic benefits, effectiveness and safety of our therapeutic candidates; </font>
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            <font style="letter-spacing:0.2pt;">our ability to receive regulatory approval for our therapeutic candidates in the United States, Europe and other geographies; </font>
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            <font style="letter-spacing:0.2pt;">the expected regulatory approval pathway for our therapeutic candidates; </font>
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            <font style="letter-spacing:0.2pt;">potential changes in regulatory requirements, and delays or negative outcomes from the regulatory approval process; </font>
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            <font style="letter-spacing:0.2pt;">our reliance on third parties for the planning, conduct and monitoring of clinical trials, for the manufacture of clinical drug supplies and drug product, and for other requirements; </font>
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            <font style="letter-spacing:0.2pt;">our estimates of the size and characteristics of the markets that may be addressed by our therapeutic candidates if approved; </font>
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            <font style="letter-spacing:0.2pt;">market acceptance of our therapeutic candidates that are approved for marketing in the United States or other countries; </font>
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            <font style="letter-spacing:0.2pt;">our ability to expand our therapeutic candidate portfolio through internal research and development or the acquisition or in-licensing of intellectual property assets; </font>
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            <font style="letter-spacing:0.2pt;">the impact of natural disasters, global pandemics (including further outbreaks of existing strains of COVID-19 or new strains of the virus), labor disputes, armed conflicts and wars, lack of raw materials or other supplies, issues with facilities and equipment or other forms of disruption to business operations at our manufacturing or laboratory facilities or those of our vendors, or at clinical trial sites; </font>
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            <font style="letter-spacing:0.2pt;">our ability to utilize our proprietary technological approach to develop and commercialize our therapeutic candidates; </font>
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            <font style="letter-spacing:0.2pt;">our heavy dependence on licensed intellectual property, including our ability to source and maintain licenses from third-party owners; </font>
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            <font style="letter-spacing:0.2pt;">our ability to protect our intellectual property and operate our business without infringing the intellectual property rights of others; </font>
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            <font style="letter-spacing:0.2pt;">our ability to attract, retain and motivate key personnel; </font>
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            <font style="letter-spacing:0.2pt;">our reliance on third-party manufacturers to manufacture and release our drug substance and drug product that meets with our designated specifications; </font>
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            <font style="letter-spacing:0.2pt;">our ability to initiate and complete our clinical trials; </font>
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            <font style="letter-spacing:0.2pt;">potential collaborations to license and commercialize any therapeutic candidates for which we receive regulatory approval in the future in or outside of the United States; </font>
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            <font style="letter-spacing:0.2pt;">clinical development involves a lengthy; complex and expensive process; with an uncertain outcome, and the results of preclinical studies, manufacturing, and early-stage clinical trials of our therapeutic candidates may not be predictive of the results of later-stage clinical trials; </font>
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          <div style=" margin-top:6pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:40pt;">
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            <font style="letter-spacing:0.2pt;">we may incur additional costs or experience delays in completing, or ultimately be unable to complete, the development, manufacturing and commercialization of TTX-MC138 or any of our other therapeutic candidates; </font>
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          <div style=" margin-top:6pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:40pt;">
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            <font style="letter-spacing:0.2pt;">our therapeutic candidates may cause undesirable side effects or death or have other properties that could halt their clinical development, prevent their regulatory approval, limit their commercial potential or result in significant negative consequences; </font>
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          <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
          <div style=" float:left; margin-left:20pt; line-height:12pt; margin-top:6pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
            <font style="font-family:Times New Roman, Times, serif;">&#10146;</font>
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          <div style=" margin-top:6pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:40pt;">
            <!--blacklining:none;-->
            <font style="letter-spacing:0.2pt;">if we are unable to advance our therapeutic candidates to clinical development, obtain regulatory approval and ultimately commercialize our therapeutic candidates, or if we experience significant delays in doing so, our business will be materially harmed; </font>
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          <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
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          <div style=" margin-top:6pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:40pt;">
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            <font style="letter-spacing:0.2pt;">even if we receive regulatory approval of TTX-MC138 or any of our other therapeutic candidates, we will be subject to ongoing regulatory requirements and continued regulatory review, which may result in significant additional expense. We may be subject to penalties if we fail to comply with regulatory requirements or experience unanticipated problems with our therapeutic candidates; </font>
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          <div style=" margin-top:6pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:40pt;">
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            <font style="letter-spacing:0.2pt;">we expect to rely on third-parties to manufacture and supply materials we require for research and development, preclinical studies and clinical trials which could result in supplies that are limited or interrupted or which may not be of satisfactory quantity or quality or other delays or disruptions; </font>
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          <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
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            <font style="letter-spacing:0.2pt;">ongoing healthcare legislative and regulatory reform measures may have a material adverse effect on our business and results of operations; </font>
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          <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
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          <div style=" margin-top:6pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:40pt;">
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            <font style="letter-spacing:0.2pt;">we are subject to geopolitical risks, economic volatility, anti-corruption laws, export and import restrictions, local regulatory authorities and the laws and medical practices in foreign jurisdictions; </font>
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          <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
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          <div style=" margin-top:6pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:40pt;">
            <!--blacklining:none;-->
            <font style="letter-spacing:0.2pt;">obtaining and maintaining regulatory approval for our therapeutic candidates in one jurisdiction does not mean that we will be successful in obtaining regulatory approval for that or of any of our other therapeutic candidates in other jurisdictions; </font>
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            <font style="letter-spacing:0.2pt;">we face substantial competition, which may result in others discovering, developing or commercializing products before or more successfully than we do; </font>
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        <div style="margin-top:2pt;margin-left:12pt;width:456pt;">
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      <div style="margin-top:2.1316282072803E-14pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:5pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">12</font>
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        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a>
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      <div style="border:1pt #000 solid;margin-top:27.85pt;min-height:694pt;margin-left:57.66pt;width:480pt;">
        <div style="margin-top:17.5pt;margin-bottom:484pt; margin-left:12pt;width:456pt;">
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            <font style="letter-spacing:0.2pt;">the price of our common stock may be volatile and fluctuate substantially, which could result in substantial losses for purchasers of our common stock; </font>
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          <div style=" margin-top:6pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:40pt;">
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            <font style="letter-spacing:0.2pt;">we have broad discretion in the use of the net proceeds from this offering and may not use them effectively; </font>
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          <div style=" margin-top:6pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:40pt;">
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            <font style="letter-spacing:0.2pt;">investors may incur dilution in the net tangible book value of the shares purchased in the offering; </font>
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          <div style=" margin-top:6pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:40pt;">
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            <font style="letter-spacing:0.2pt;">we have identified material weaknesses in our internal control over financial reporting. If we are unable to remediate these material weaknesses, or if we identify additional material weaknesses in the future or otherwise fail to maintain an effective system of internal controls, we may not be able to accurately or timely report our financial condition or results of operations, which may adversely affect our business and the trading price of our common stock; and </font>
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            <font style="letter-spacing:0.2pt;">other risks and uncertainties, including those listed under the caption &#8220;Risk Factors&#8221; in our Annual Report on Form 10-K and in our other regulatory filings, including our <a style="-sec-extract:exhibit" href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1829635/000155837024015731/rnaz-20240930x10q.htm">Quarterly Report on Form 10-Q filed with the SEC on November&#160;14, 2024.</a> </font>
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      <div style="margin-top:2.1316282072803E-14pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:5pt; text-align:right; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">13</font>
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        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a><a name="tTHOF">&#8203;</a>
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      <div style="border:1pt #000 solid;margin-top:27.85pt;min-height:694pt;margin-left:57.66pt;width:480pt;">
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          <div style="margin-top:0pt; text-align:center; width:456pt; line-height:20pt;font-weight:bold;font-size:18pt;">
            <font style="letter-spacing:-0.36pt;">The Offering</font><font style="font-weight:normal;letter-spacing:0.36pt;"> </font>
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          <div style="width:144pt;">
            <div style="margin-left:10pt; text-indent:-10pt; margin-top:6pt; line-height:12pt;">
              <font style="letter-spacing:0.2pt;">Issuer </font>
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          <div style="margin-left:168pt; margin-top:-12pt; width:288pt; line-height:12pt;">
            <font style="letter-spacing:0.2pt;">TransCode Therapeutics, Inc. </font>
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            <div style="margin-left:10pt; text-indent:-10pt; margin-top:6pt; line-height:12pt;">
              <font style="letter-spacing:0.2pt;">Securities Offered by Selling Stockholders </font>
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          <div style="margin-left:168pt; margin-top:-12pt; width:288pt; line-height:12pt;">
            <font style="letter-spacing:0.2pt;">(i) 173,033 shares of Common Stock issued in the PIPE; (ii)&#160;470,007 shares of Common Stock issuable upon the exercise of the PIPE PFWs; (iii)&#160;up to 4,050,953 common shares underlying the Series&#160;C Common Warrants; and (iv)&#160;up to 12,152,856 common shares underlying the Series&#160;D Common Warrants </font>
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            <div style="margin-left:10pt; text-indent:-10pt; margin-top:6pt; line-height:12pt;">
              <font style="letter-spacing:0.2pt;">Terms of the Warrants</font>
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          <div style="margin-left:168pt; margin-top:-12pt; width:288pt; line-height:12pt;">
            <font style="letter-spacing:0.2pt;">Each Series&#160;C Warrant has an initial exercise price per share of $15.675 and will be exercisable beginning on the date on which Stockholder Approval (as defined below) is received and deemed effective (the &#8220;</font><font style=" text-decoration:underline #000000 solid;letter-spacing:0.2pt;">Initial Exercise Date</font><font style="letter-spacing:0.2pt;">&#8221; or the &#8220;</font><font style=" text-decoration:underline #000000 solid;letter-spacing:0.2pt;">Stockholder Approval Date</font><font style="letter-spacing:0.2pt;">&#8221;). The Series&#160;C Warrants will expire on the five-year anniversary of the Initial Exercise Date. Additionally, the Series&#160;C Warrants provide for an adjustment to the exercise price and number of shares underlying such the Series&#160;C Warrants upon the Company&#8217;s issuance of common shares or common share equivalents at a price per share that is less than the exercise price of the Series&#160;C Warrants, subject to a floor price of $2.4882 (the &#8220;</font><font style=" text-decoration:underline #000000 solid;letter-spacing:0.2pt;">Floor Price</font><font style="letter-spacing:0.2pt;">&#8221;). </font>
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          <div style="margin-left:168pt; margin-top:12pt; width:288pt; line-height:12.5pt;">
            <font style="letter-spacing:0.2pt;">The Series&#160;D Warrants have an initial exercise price per share of $15.675 and will be exercisable beginning on the Initial Exercise Date. The Series&#160;D Warrants will expire two and one-half&#160;years after the Initial Exercise Date. Under an alternative cashless exchange provision in the Series&#160;D Warrants, holders thereof have the right to receive an aggregate number of shares equal to the product of (i)&#160;the aggregate number of common shares that would be issuable upon a cash exercise of the Series&#160;D Warrants and (ii)&#160;3.0. </font>
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          <div style="margin-left:168pt; margin-top:12pt; width:288pt; line-height:12.5pt;">
            <font style="letter-spacing:0.2pt;">In addition, on the 11th trading day following each of (i)&#160;the later of (A)&#160;the Stockholder Approval Date and (B)&#160;the Effective Date (as that term is defined in the PIPE SPA) and (ii)&#160;each subsequent date that a Registration Statement (as that term is defined in the PIPE SPA) is declared effective by the Securities and Exchange Commission, if any (each such trading day, a &#8220;</font><font style=" text-decoration:underline #000000 solid;letter-spacing:0.2pt;">Reset Date</font><font style="letter-spacing:0.2pt;">&#8221;), the Series&#160;C Warrants and the Series&#160;D Warrants contain a reset of the exercise price to a price equal to the lesser of (i)&#160;the then applicable exercise price and (ii)&#160;the greater of the Floor Price and the lowest volume weighted average price for the ten trading days immediately preceding the Reset Date. Upon such reset of the exercise price, the number of shares issuable under the Common Warrants shall be increased such that the aggregate exercise price of the Common Warrants shall remain unchanged following such reset. </font>
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          <div style="margin-left:168pt; margin-top:12pt; width:288pt; line-height:12pt;">
            <font style="letter-spacing:0.2pt;">The issuance of shares of Common Stock upon exercise of the Common Warrants is subject to stockholder approval under applicable rules and regulations of The Nasdaq Stock Market LLC (&#8220;</font><font style=" text-decoration:underline #000000 solid;letter-spacing:0.2pt;">Nasdaq</font><font style="letter-spacing:0.2pt;">&#8221;) (&#8220;</font><font style=" text-decoration:underline #000000 solid;letter-spacing:0.2pt;">Stockholder Approval</font><font style="letter-spacing:0.2pt;">&#8221; and the date on which Stockholder Approval is received and deemed effective, the &#8220;</font><font style=" text-decoration:underline #000000 solid;letter-spacing:0.2pt;">Stockholder Approval Date</font><font style="letter-spacing:0.2pt;">&#8221;). The Company intends to hold a shareholder meeting to obtain Stockholder Approval within 70&#160;days following the closing of the PIPE. </font>
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        <div style="margin-top:2pt;margin-left:12pt;width:456pt;">
          <div style="margin-top:5pt; text-align:center; width:456pt; line-height:12pt;">
            <font style="letter-spacing:0.2pt;">&#160;</font>
            <br >
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        </div>
      </div>
      <div style="margin-top:2.1316282072803E-14pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:5pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">14</font>
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    <div style="page-break-after:always; width:595.3pt;margin-left:auto;margin-right:auto;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
      <div style="padding:0pt;margin:0pt;font-family:calibri, arial, sans-serif;font-weight:normal;font-style:normal;font-size:8pt;line-height:8pt;">
        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a>
      </div>
      <div style="border:1pt #000 solid;margin-top:27.85pt;min-height:694pt;margin-left:57.66pt;width:480pt;">
        <div style="margin-top:17.5pt;margin-bottom:210pt; margin-left:12pt;width:456pt;">
          <div style="width:144pt;">
            <div style="margin-left:10pt; text-indent:-10pt; line-height:12pt;">
              <font style="letter-spacing:0.2pt;">Shares of Common Stock Outstanding Prior to this Offering(1) </font>
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          <div style="margin-left:168pt; margin-top:-12pt; width:288pt; line-height:12pt;">
            <font style="letter-spacing:0.2pt;">696,249 shares of Common Stock: </font>
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          <div style="width:144pt;">
            <div style="margin-left:10pt; text-indent:-10pt; margin-top:6pt; line-height:12pt;">
              <font style="letter-spacing:0.2pt;">Shares of Common Stock Outstanding Assuming Exercise of All PIPE </font>
              <br >
              <font style="letter-spacing:0.2pt;">PFWs(1): </font>
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          <div style="margin-left:168pt; margin-top:-12pt; width:288pt; line-height:12pt;">
            <font style="letter-spacing:0.2pt;">1,166,256 shares of Common Stock </font>
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          <div style="width:144pt;">
            <div style="margin-left:10pt; text-indent:-10pt; margin-top:6pt; line-height:12pt;">
              <font style="letter-spacing:0.2pt;">Terms of the Offering </font>
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          <div style="margin-left:168pt; margin-top:-12pt; width:288pt; line-height:12pt;">
            <font style="letter-spacing:0.2pt;">The Selling Stockholders will each determine when and how they will sell the Resale Shares offered in this prospectus, as described in the &#8220;</font><font style="font-style:italic;letter-spacing:0.2pt;">Plan of Distribution</font><font style="letter-spacing:0.2pt;">.&#8221; </font>
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            <div style="margin-left:10pt; text-indent:-10pt; margin-top:6pt; line-height:12pt;">
              <font style="letter-spacing:0.2pt;">Use of Proceeds </font>
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          <div style="margin-left:168pt; margin-top:-12pt; width:288pt; line-height:12pt;">
            <font style="letter-spacing:0.2pt;">We will not receive any proceeds from the sale by the Selling Stockholders of the Common Stock issued in the PIPE. We will, however, receive the net proceeds of any Warrants exercised for cash. See &#8220;</font><font style="font-style:italic;letter-spacing:0.2pt;">Use of Proceeds</font><font style="letter-spacing:0.2pt;">.&#8221; </font>
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            <div style="margin-left:10pt; text-indent:-10pt; margin-top:6pt; line-height:12pt;">
              <font style="letter-spacing:0.2pt;">Risk Factors </font>
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          <div style="margin-left:168pt; margin-top:-12pt; width:288pt; line-height:12pt;">
            <font style="letter-spacing:0.2pt;">See &#8220;</font><font style="font-style:italic;letter-spacing:0.2pt;">Risk Factors</font><font style="letter-spacing:0.2pt;">&#8221; incorporated by reference into this prospectus from our most current Annual Report on Form 10-K and subsequent Quarterly Reports on Form 10-Q, for a discussion of certain factors you should carefully consider before deciding to invest in our Common Stock. </font>
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            <div style="white-space:nowrap; margin-left:10pt; text-indent:-10pt; margin-top:6pt; line-height:12pt;">
              <font style="letter-spacing:0.2pt;">Nasdaq Capital Market </font>
              <br >
              <font style="letter-spacing:0.2pt;">Symbol </font>
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          <div style="margin-left:168pt; margin-top:-12pt; width:288pt; line-height:12pt;">
            <font style="letter-spacing:0.2pt;">RNAZ</font>
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            <font style=" position:relative; bottom:4.25pt;font-size:7.5pt;letter-spacing:0.15pt;">1)</font>
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          <div style=" margin-top:4pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:10pt;">
            <!--blacklining:none;-->
            <font style="letter-spacing:0.2pt;">The number of shares of Common Stock is based on 696,249 shares of our Common Stock outstanding as of December&#160;4, 2024, and excludes as of that date: </font>
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          <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
          <div style=" float:left; margin-left:20pt; line-height:12pt; margin-top:6pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
            <font style="font-family:Times New Roman, Times, serif;">&#10146;</font>
            <br >
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          <div style=" margin-top:6pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:40pt;">
            <!--blacklining:none;-->
            <font style="letter-spacing:0.2pt;">470,007 shares of Common Stock issuable upon exercise of outstanding pre-funded warrants; </font>
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          <div style=" float:left; margin-left:20pt; line-height:12pt; margin-top:6pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
            <font style="font-family:Times New Roman, Times, serif;">&#10146;</font>
            <br >
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          <div style=" margin-top:6pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:40pt;">
            <!--blacklining:none;-->
            <font style="letter-spacing:0.2pt;">58,096 shares of Common Stock issuable upon the exercise of stock options with a weighted average exercise price of $83.82 per share; </font>
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          <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
          <div style=" float:left; margin-left:20pt; line-height:12pt; margin-top:6pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
            <font style="font-family:Times New Roman, Times, serif;">&#10146;</font>
            <br >
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          <div style=" margin-top:6pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:40pt;">
            <!--blacklining:none;-->
            <font style="letter-spacing:0.2pt;">1,656,729 shares of Common Stock issuable upon exercise of outstanding warrants with a weighted average exercise price of $30.55 per share; and </font>
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          <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
          <div style=" float:left; margin-left:20pt; line-height:12pt; margin-top:6pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
            <font style="font-family:Times New Roman, Times, serif;">&#10146;</font>
            <br >
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          <div style=" margin-top:6pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:40pt;">
            <!--blacklining:none;-->
            <font style="letter-spacing:0.2pt;">16,203,809 shares of Common Stock issuable upon exercise of the Series&#160;C Warrants and the Series&#160;D Warrants </font>
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          <div style="margin-top:12pt; width:456pt; line-height:12pt;">
            <font style="letter-spacing:0.2pt;">Unless otherwise indicated, all information in this prospectus supplement assumes no exercise of the outstanding options or warrants described above.</font>
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          <font style="letter-spacing:0.2pt;">15</font>
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        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a><a name="tRIFA">&#8203;</a>
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        <div style="margin-top:6pt; width:456pt; line-height:14pt;font-size:12pt;">
          <font style="letter-spacing:0.24pt;">&#160;</font>
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          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
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          <font style="letter-spacing:-0.36pt;">R</font><font style="text-transform:lowercase;letter-spacing:-0.36pt;">ISK</font><font style="letter-spacing:-0.36pt;"> F</font><font style="text-transform:lowercase;letter-spacing:-0.36pt;">ACTORS</font><font style="font-weight:normal;letter-spacing:0.36pt;"> </font>
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        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:0.2pt;">Investing in our Common Stock involves a high degree of risk. Our business is influenced by many factors that are difficult to predict, involve uncertainties that may materially affect actual results and are often beyond our control. You should consider carefully the risks and uncertainties under the heading &#8220;</font><font style="font-style:italic;letter-spacing:0.2pt;">Risk Factors</font><font style="letter-spacing:0.2pt;">&#8221; in our <a style="-sec-extract:exhibit" href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1829635/000141057824000413/rnaz-20231231x10k.htm">Annual Report on Form 10-K for the fiscal year ended December&#160;31, 2023</a> and our Quarterly Reports for the fiscal periods ended <a style="-sec-extract:exhibit" href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1829635/000155837024008298/rnaz-20240331x10q.htm">March&#160;31, 2024</a>, <a style="-sec-extract:exhibit" href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1829635/000155837024012264/rnaz-20240630x10q.htm">June&#160;30, 2024</a>, and <a style="-sec-extract:exhibit" href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1829635/000155837024015731/rnaz-20240930x10q.htm">September&#160;30, 2024</a>, which are each incorporated by reference in this prospectus, as well as any amendment or update to our risk factors in subsequent filings with the SEC, and other information in our financial statements and notes thereto, all of which are incorporated by reference into this prospectus, before deciding to invest in our Common Stock. If any of the described risks incorporated by reference hereto were to materialize, our business, financial condition, results of operations, and future growth prospects could be materially and adversely affected. In that event, the market price of our Common Stock could decline, and you could lose part of or all of your investment in our Common Stock. See the section of this prospectus titled &#8220;</font><font style="font-style:italic;letter-spacing:0.2pt;">Where You Can Find More Information</font><font style="letter-spacing:0.2pt;">.&#8221; </font>
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        <div style="margin-top:12pt; width:456pt; line-height:14pt;font-weight:bold;font-size:12pt;">
          <font style="letter-spacing:-0.24pt;">Risks Related to Sales by Selling Stockholders</font><font style="font-weight:normal;letter-spacing:0.24pt;"> </font>
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          <font style="letter-spacing:-0.2pt;">Sales of substantial amounts of our common shares by a Selling Stockholder, or the perception that sales could occur, could adversely affect the price of our common shares.</font><font style="font-style:normal;font-weight:normal;letter-spacing:0.2pt;"> </font>
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        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:0.2pt;">The sale by Selling Stockholders of a significant number of common shares could have a material adverse effect on the market price of our common shares. In addition, the perception in the public markets that the Selling Stockholders may sell all or a portion of their shares as a result of the registration of such shares for resale pursuant to this prospectus could also in and of itself have a material adverse effect on the market price of our common shares. We cannot predict the effect, if any, that market sales of common shares by Selling Stockholders, or the availability of their common shares for sale, will have on the market price of our common shares. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;font-style:italic;font-weight:bold;">
          <font style="letter-spacing:-0.2pt;">The exercise of the Warrants, including their reset and anti-dilution features, may result in substantial dilution to purchasers of our Common Stock and may adversely affect the market price of our Common Stock.</font><font style="font-style:normal;font-weight:normal;letter-spacing:0.2pt;"> </font>
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        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:0.2pt;">On November&#160;26, 2024, we entered into the PIPE SPA with the Selling Stockholders in connection with which we issued to the Selling Stockholders our Series&#160;C Warrants and Series&#160;D Warrants. Each Series&#160;C Warrant has an initial exercise price per share of $15.675 and will be exercisable beginning on the date on which Stockholder Approval (as defined below) is received and deemed effective (the &#8220;Initial Exercise Date&#8221; or the &#8220;Stockholder Approval Date&#8221;). The Series&#160;C Warrants will expire on the five-year anniversary of the Initial Exercise Date. Additionally, the Series&#160;C Warrants provide for an adjustment to the exercise price and number of shares underlying such Series&#160;C Warrants upon our issuance of common shares or common share equivalents at a price per share that is less than the exercise price of the Series&#160;C Warrants, subject to a floor price of $ 2.4882 per share (the &#8220;Floor Price&#8221;). The Series&#160;D Warrants have an initial exercise price per share of $15.675 and will be exercisable beginning on the Initial Exercise Date. Under an alternative cashless exchange provision in the Series&#160;D Warrants, holders thereof have the right to receive an aggregate number of shares equal to the product of (i)&#160;the aggregate number of common shares that would be issuable upon a cash exercise of the Series&#160;D Warrants and (ii)&#160;3.0. In addition, on the 11th trading day following each of (i)&#160;the later of (A)&#160;the Stockholder Approval Date and (B)&#160;the Effective Date (as that term is defined in the PIPE SPA) and (ii)&#160;each subsequent date that a Registration Statement (as that term is defined in the PIPE SPA) is declared effective by the Securities and Exchange Commission, if any (each such trading day, a &#8220;Reset Date&#8221;), the Series&#160;C Warrants and the Series&#160;D Warrants contain a reset of the exercise price to a price equal to the lesser of (i)&#160;the then applicable exercise price and (ii)&#160;the greater of the Floor Price and the lowest volume weighted average price for the ten trading days immediately preceding the Reset Date. Upon such reset of the exercise price, the number of shares issuable under the Common Warrant shall be increased such that the aggregate exercise price of the Common Warrant shall remain unchanged following such reset. The issuance of shares of Common Stock upon exercise of the Common Warrants is subject to stockholder approval under applicable rules and regulations of The Nasdaq Stock </font>
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          <font style="letter-spacing:0.2pt;">16</font>
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        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a>
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          <font style="letter-spacing:0.24pt;">R</font><font style="text-transform:lowercase;letter-spacing:0.24pt;">ISK</font><font style="letter-spacing:0.24pt;"> F</font><font style="text-transform:lowercase;letter-spacing:0.24pt;">ACTORS</font>
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          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
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          <font style="letter-spacing:0.2pt;">Market LLC (&#8220;Nasdaq&#8221;) (&#8220;Stockholder Approval&#8221; and the date on which Stockholder Approval is received and deemed effective, the &#8220;Stockholder Approval Date&#8221;). The Company intends to hold a shareholder meeting to obtain Stockholder Approval within 70 days following the closing of the PIPE.</font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">The reset feature in the Warrants may adjust the exercise price downward and increase the number of shares issuable upon exercise under certain conditions thereby causing further dilution to existing stockholders, including purchasers of our common stock. This additional dilution could be significant, depending on the extent of the adjustments triggered by the reset provisions and the number of warrants exercised. </font>
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          <font style="letter-spacing:0.2pt;">The potential for increased dilution due to the reset feature may exert downward pressure on the market price of our common stock, as investors anticipate the possibility of additional shares entering the market. Moreover, the uncertainty surrounding the number of shares that ultimately may be issued upon exercise of these warrants could make our common stock less attractive to investors, potentially further depressing our stock price. </font>
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          <font style="letter-spacing:0.2pt;">The issuance of additional shares upon exercise of the warrants with reset features could also make it more difficult for us to raise additional capital through future offerings of equity securities. Investors may be concerned about the dilutive effects of such features, which could impair our ability to secure financing on favorable terms if at all. Purchasers of our common stock may experience immediate and substantial dilution in the net tangible book value per share of their investment upon the exercise of these warrants, especially if the reset features are triggered and result in issuances of additional shares. </font>
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          <font style="letter-spacing:0.2pt;">17</font>&#8203;</div>
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        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a><a name="tUOP">&#8203;</a>
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      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:6pt; width:456pt; line-height:14pt;font-size:12pt;">
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          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
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          <font style="letter-spacing:-0.36pt;">U</font><font style="text-transform:lowercase;letter-spacing:-0.36pt;">SE OF</font><font style="letter-spacing:-0.36pt;"> P</font><font style="text-transform:lowercase;letter-spacing:-0.36pt;">ROCEEDS</font><font style="font-weight:normal;letter-spacing:0.36pt;"> </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">We are not selling common shares for our own account under this prospectus and we will not receive any proceeds from any sales by Selling Stockholders of our common stock covered by this prospectus and any accompanying prospectus supplement. All proceeds from the sale of the common stock by the Selling Stockholders will be for their own accounts. We will, however, receive the net proceeds of any Warrants exercised for cash. Proceeds, if any, received from the exercise of such Warrants will be used for working capital and for general corporate purposes. No assurances can be given that any of such Warrants will be exercised. </font>
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          <font style="letter-spacing:0.2pt;">Each Selling Stockholder will pay any discounts, commissions, and fees of underwriters, selling brokers, dealer managers or similar securities industry professionals incurred by such Selling Stockholder in disposing of the Resale Shares covered by this prospectus. We will bear all other costs, fees and expenses incurred in effecting the registration of the offer and sale of the Resale Shares covered by this prospectus and any accompanying prospectus supplement, including, without limitation, all registration and filing fees, Nasdaq listing fees and fees and expenses of our counsel and our accountants. </font>
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          <font style="letter-spacing:0.2pt;">18</font>
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          <font style="letter-spacing:-0.36pt;">D</font><font style="text-transform:lowercase;letter-spacing:-0.36pt;">ETERMINATION OF</font><font style="letter-spacing:-0.36pt;"> O</font><font style="text-transform:lowercase;letter-spacing:-0.36pt;">FFERING</font><font style="letter-spacing:-0.36pt;"> P</font><font style="text-transform:lowercase;letter-spacing:-0.36pt;">RICE</font><font style="font-weight:normal;letter-spacing:0.36pt;"> </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;font-family:Times New Roman, Times, serif ;font-size:10pt;">
          <font style="letter-spacing:0.2pt;">We cannot determine in advance the price or prices at which the shares of Common Stock may be sold by the Selling Stockholders under this prospectus. </font>
        </div>
      </div>
      <div style="margin-top:0pt;height:12pt;margin-left:69.66pt;width:456pt;">
        <div style="text-align:center; width:456pt; line-height:12pt;font-family:Times New Roman, Times, serif ;font-size:10pt;">
          <font style="letter-spacing:0.2pt;">&#160;</font>
          <br >
        </div>
      </div>
      <div style="margin-top:2pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
        <div style="width:456pt;">
          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
        </div>
        <div style="margin-top:3pt; text-align:right; width:456pt; line-height:13pt;font-family:Times New Roman, Times, serif ;font-size:10pt;">
          <font style="letter-spacing:0.2pt;">19</font>&#8203;</div>
      </div>
      <hr >
    </div>
    <div style="page-break-after:always; width:595.3pt;margin-left:auto;margin-right:auto;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
      <div style="padding:0pt;margin:0pt;font-family:calibri, arial, sans-serif;font-weight:normal;font-style:normal;font-size:8pt;line-height:8pt;">
        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a><a name="tTSS">&#8203;</a>
      </div>
      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:6pt; width:456pt; line-height:14pt;font-size:12pt;">
          <font style="letter-spacing:0.24pt;">&#160;</font>
        </div>
        <div style="margin-top:5.833pt; width:456pt;">
          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
        </div>
      </div>
      <div style="margin-top:6pt;margin-left:69.66pt;width:456pt;">
        <div style="text-align:center; width:456pt; line-height:20pt;font-weight:bold;font-size:18pt;">
          <font style="letter-spacing:-0.36pt;">T</font><font style="text-transform:lowercase;letter-spacing:-0.36pt;">HE</font><font style="letter-spacing:-0.36pt;"> S</font><font style="text-transform:lowercase;letter-spacing:-0.36pt;">ELLING</font><font style="letter-spacing:-0.36pt;"> S</font><font style="text-transform:lowercase;letter-spacing:-0.36pt;">TOCKHOLDERS</font><font style="font-weight:normal;letter-spacing:0.36pt;"> </font>
        </div>
        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:0.2pt;">The shares of Common Stock being offered by the Selling Stockholders are those previously issued to the Selling Stockholder, and those issuable to the Selling Stockholders upon exercise of the Warrants. For additional information regarding the issuances of those shares of Common Stock and Warrant Shares, see &#8220;</font><font style="font-style:italic;letter-spacing:0.2pt;">The Offering.</font><font style="letter-spacing:0.2pt;">&#8221;. We are registering the Resale Securities in order to permit the Selling Stockholders to offer the shares for resale from time to time. Except for the ownership of the shares of Common Stock and the Warrants, as well as their other purchases of other securities from us, if any, the Selling Stockholders have not had any material relationship with us within the past three&#160;years. </font>
        </div>
        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:0.2pt;">The shares offered by this prospectus may be sold from time to time on Nasdaq, in privately negotiated transactions or otherwise. We have agreed to prepare and file amendments and supplements to the registration statement to the extent necessary to keep the registration statement effective for the period of time required under our agreement with the Selling Stockholders. </font>
        </div>
        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:0.2pt;">All information with respect to the Selling Stockholders&#8217; ownership of the Resale Shares has been furnished by or on behalf of the Selling Stockholders and is as of December&#160;2, 2024. The&#160;percentage ownership data is based on 696,249 shares of Common Stock issued and outstanding as of December&#160;2, 2024. We believe, based on information supplied by the Selling Stockholders, that except as may otherwise be indicated in the table below, the Selling Stockholders and their affiliates listed in any footnote to the table below have sole voting and dispositive power with respect to the shares of Common Stock reported as beneficially owned by them. </font>
        </div>
        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:0.2pt;">The aggregate number of shares of Common Stock that the Selling Stockholders may offer and sell pursuant to this prospectus is based upon (i)&#160;the number of shares of Common Stock issued them in the PIPE; (ii)&#160;the number of shares of Common Stock that may be issued to the Selling Stockholders upon their exercise of PIPE PFWs; and (iii)&#160;the number of shares of Common Stock that may be issued to the Selling Stockholders upon their exercise of the Common Warrants. The Selling Stockholders may sell some, all or none of the Resale Shares. We do not know how long the Selling Stockholders will hold the Resale Shares before selling them, and we currently have no agreements, arrangements or understandings with any Selling Stockholder regarding the sale or other disposition of any of the Resale Shares or any other shares of Common Stock. The Resale Shares may be offered and sold from time to time by the Selling Stockholders pursuant to this prospectus. </font>
        </div>
        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">The Series&#160;C Warrants and the Series&#160;D Warrants contain a reset of the exercise price to a price equal to the lesser of (i)&#160;the then applicable exercise price and (ii)&#160;the greater of the Floor Price and the lowest volume weighted average price for the ten trading days immediately preceding the Reset Date. Upon such reset of the exercise price, the number of shares issuable under the Common Warrant shall be increased such that the aggregate exercise price of the Common Warrant shall remain unchanged following such reset. Due to this anti-dilution feature, we have included in the third column in the table below the maximum number of shares of Common Stock that can be issued upon exercise of the Warrants. </font>
        </div>
        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">Because the Selling Stockholders may sell some or all of the Resale Shares included in this prospectus, and because there are currently no agreements, arrangements or understandings with respect to the sale of any of the Resale Shares, no estimate can be given as to the number of shares of Common Stock available for resale hereby that will be held by the Selling Stockholders in the future. In addition, the Selling Stockholders may have sold, transferred or otherwise disposed of, or may sell, transfer or otherwise dispose of, at any time and from time to time, Resale Shares they hold in transactions exempt from the registration requirements of the Securities Act after the date on which they provided the information set forth in the table below. We have, therefore, assumed for the purposes of the following table, that the Selling Stockholders will sell all of the Resale Shares owned beneficially by them and their affiliates listed in any footnote to the table below that are covered by this prospectus, but not any other shares of Common Stock they may beneficially own. </font>
        </div>
        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">Under the terms of the Warrants, a Selling Stockholder may not exercise the Warrants to the extent such exercise would cause such Selling Stockholder, together with its affiliates and attribution parties, to beneficially </font>
        </div>
      </div>
      <div style="margin-top:2.00000000000002pt;height:12pt;margin-left:69.66pt;width:456pt;">
        <div style="text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">&#160;</font>
          <br >
        </div>
      </div>
      <div style="margin-top:2pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
        <div style="width:456pt;">
          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
        </div>
        <div style="margin-top:3pt; width:456pt; line-height:13pt;">
          <font style="letter-spacing:0.2pt;">20</font>
        </div>
      </div>
      <hr >
    </div>
    <div style="page-break-after:always; width:595.3pt;margin-left:auto;margin-right:auto;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
      <div style="padding:0pt;margin:0pt;font-family:calibri, arial, sans-serif;font-weight:normal;font-style:normal;font-size:8pt;line-height:8pt;">
        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a>
      </div>
      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:6pt; width:456pt; line-height:14pt;font-size:12pt;">
          <font style="letter-spacing:0.24pt;">T</font><font style="text-transform:lowercase;letter-spacing:0.24pt;">HE</font><font style="letter-spacing:0.24pt;"> S</font><font style="text-transform:lowercase;letter-spacing:0.24pt;">ELLING</font><font style="letter-spacing:0.24pt;"> S</font><font style="text-transform:lowercase;letter-spacing:0.24pt;">TOCKHOLDERS</font>
        </div>
        <div style="margin-top:5.833pt; width:456pt;">
          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
        </div>
      </div>
      <div style="margin-top:6pt;margin-left:69.66pt;width:456pt;">
        <div style="width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:0.2pt;">own a number of common shares which would exceed 4.99% or, at their election, 9.99%, of our common shares following such exercise, excluding for purposes of such determination common shares issuable upon exercise of the Warrants which have not been exercised. The number of common shares in the fourth column below does not reflect this limitation. </font>
        </div>
        <table style="width:456pt;margin-top:14pt;border-collapse: collapse;border-top:0.75pt solid #000000; font-style:normal;font-weight:bold;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
          <tr style="line-height:10pt;white-space:nowrap;text-align:left;vertical-align:bottom;font-style:normal;font-weight:bold;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="border-bottom:1px solid #FFFFFF;padding:0pt 0pt 0.5pt 0pt; width:147.68pt;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:2.5pt;">&#8203;</td>
            <td style="border-bottom:1px solid #000000;padding:2.5pt 0pt 2.5pt 0pt; width:0pt;text-align:center;" colspan="28">
              <div style="white-space:nowrap; text-align:center;">
                <font style="letter-spacing:-0.2pt;">Selling Stockholder Information: </font>
              </div>
            </td>
            <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:12pt;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:bold;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="border-bottom:1px solid #000000;padding:1.417pt 0pt 1.833pt 0pt; width:147.68pt;text-align:left;">
              <div style="white-space:nowrap;">
                <font style="letter-spacing:-0.2pt;">Selling Stockholders(1) </font>
              </div>
            </td>
            <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:2.5pt;">&#8203;</td>
            <td style="border-bottom:1px solid #000000;padding:1.417pt 0pt 1.833pt 0pt;" colspan="4">
              <div style="text-align:center;">
                <font style="letter-spacing:-0.2pt;">Common </font>
                <br >
                <font style="letter-spacing:-0.2pt;">Stock</font>
                <br >
                <font style="letter-spacing:-0.2pt;">Owned</font>
                <br >
                <font style="letter-spacing:-0.2pt;">Immediately</font>
                <br >
                <font style="letter-spacing:-0.2pt;">Prior</font>
                <br >
                <font style="letter-spacing:-0.2pt;">to this</font>
                <br >
                <font style="letter-spacing:-0.2pt;">Offering(2) </font>
              </div>
            </td>
            <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:2.5pt;">&#8203;</td>
            <td style="border-bottom:1px solid #000000;padding:1.417pt 0pt 1.833pt 0pt;" colspan="4">
              <div style="text-align:center;">
                <font style="letter-spacing:-0.2pt;">Common </font>
                <br >
                <font style="letter-spacing:-0.2pt;">Stock and</font>
                <br >
                <font style="letter-spacing:-0.2pt;">PFW Shares </font>
                <br >
                <font style="letter-spacing:-0.2pt;">Being</font>
                <br >
                <font style="letter-spacing:-0.2pt;">Offered</font>
                <br >
                <font style="letter-spacing:-0.2pt;">for Resale</font>
                <br >
                <font style="letter-spacing:-0.2pt;">Under this</font>
                <br >
                <font style="letter-spacing:-0.2pt;">Prospectus(3) </font>
              </div>
            </td>
            <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:2.5pt;">&#8203;</td>
            <td style="border-bottom:1px solid #000000;padding:1.417pt 0pt 1.833pt 0pt;" colspan="4">
              <div style="text-align:center;">
                <font style="letter-spacing:-0.2pt;">Common </font>
                <br >
                <font style="letter-spacing:-0.2pt;">Warrant</font>
                <br >
                <font style="letter-spacing:-0.2pt;">Shares Being</font>
                <br >
                <font style="letter-spacing:-0.2pt;">Offered </font>
                <br >
                <font style="letter-spacing:-0.2pt;">for Resale</font>
                <br >
                <font style="letter-spacing:-0.2pt;">Under this</font>
                <br >
                <font style="letter-spacing:-0.2pt;">Prospectus(4) </font>
              </div>
            </td>
            <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:2.5pt;">&#8203;</td>
            <td style="border-bottom:1px solid #000000;padding:1.417pt 0pt 1.833pt 0pt;" colspan="4">
              <div style="text-align:center;">
                <font style="letter-spacing:-0.2pt;">Number of </font>
                <br >
                <font style="letter-spacing:-0.2pt;">Shares</font>
                <br >
                <font style="letter-spacing:-0.2pt;">Beneficially</font>
                <br >
                <font style="letter-spacing:-0.2pt;">Owned After</font>
                <br >
                <font style="letter-spacing:-0.2pt;">Sale of</font>
                <br >
                <font style="letter-spacing:-0.2pt;">Common </font>
                <br >
                <font style="letter-spacing:-0.2pt;">Stock</font>
                <br >
                <font style="letter-spacing:-0.2pt;">PFW Shares </font>
                <br >
                <font style="letter-spacing:-0.2pt;">and Warrant </font>
                <br >
                <font style="letter-spacing:-0.2pt;">Shares(5) </font>
              </div>
            </td>
            <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:2.5pt;">&#8203;</td>
            <td style="border-bottom:1px solid #000000;padding:1.417pt 0pt 1.833pt 0pt;" colspan="4">
              <div style="text-align:center;">
                <font style="letter-spacing:-0.2pt;">Percentage of</font>
                <br >
                <font style="letter-spacing:-0.2pt;">Outstanding </font>
                <br >
                <font style="letter-spacing:-0.2pt;">Shares of </font>
                <br >
                <font style="letter-spacing:-0.2pt;">Common Stock</font>
                <br >
                <font style="letter-spacing:-0.2pt;">Beneficially </font>
                <br >
                <font style="letter-spacing:-0.2pt;">Owned</font>
                <br >
                <font style="letter-spacing:-0.2pt;">Immediately </font>
                <br >
                <font style="letter-spacing:-0.2pt;">Following </font>
                <br >
                <font style="letter-spacing:-0.2pt;">the Sale of</font>
                <br >
                <font style="letter-spacing:-0.2pt;">Common Stock </font>
                <br >
                <font style="letter-spacing:-0.2pt;">and Warrant </font>
                <br >
                <font style="letter-spacing:-0.2pt;">Shares(6) </font>
              </div>
            </td>
            <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:10pt;background-color:#CCEEFF;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:bold;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:2.75pt 0pt 2pt 0pt; width:147.68pt;text-align:left;">
              <font style="letter-spacing:-0.2pt;">2024 Selling Stockholders</font>
            </td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:9.525pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt 0pt 0.5pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:0pt 0pt 0.5pt 0pt; min-width:24.75pt; text-align:right; white-space:nowrap;">&#8203;</td>
            <td style="padding:0pt;padding-left:9.525pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:11.98pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt 0pt 0.5pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:0pt 0pt 0.5pt 0pt; min-width:24.75pt; text-align:right; white-space:nowrap;">&#8203;</td>
            <td style="padding:0pt;padding-left:11.98pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:5.63pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt 0pt 0.5pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:0pt 0pt 0.5pt 0pt; min-width:34.5pt; text-align:right; white-space:nowrap;">&#8203;</td>
            <td style="padding:0pt;padding-left:5.63pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:10.57pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt 0pt 0.5pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:0pt 0pt 0.5pt 0pt; min-width:24.75pt; text-align:right; white-space:nowrap;">&#8203;</td>
            <td style="padding:0pt;padding-left:10.57pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:27.185pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt 0pt 0.5pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:0pt 0pt 0.5pt 0pt; min-width:7.5pt; text-align:right; white-space:nowrap;">&#8203;</td>
            <td style="padding:0pt;padding-left:27.185pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:10pt;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:3pt 0pt 2pt 0pt; width:147.68pt;text-align:left;">
              <div style="white-space:nowrap;">
                <font style="letter-spacing:0.2pt;">Anson East Master Fund&#160;LP(7) </font>
              </div>
            </td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:9.525pt;width:0pt;">&#8203;</td>
            <td style="padding:3pt 0pt 2pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3pt 0pt 2pt 0pt; min-width:24.75pt; text-align:right; white-space:nowrap;">&#8212;</td>
            <td style="padding:0pt;padding-left:9.525pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:11.98pt;width:0pt;">&#8203;</td>
            <td style="padding:3pt 0pt 2pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3pt 0pt 2pt 0pt; min-width:24.75pt; text-align:right; white-space:nowrap;">26,526</td>
            <td style="padding:0pt;padding-left:11.98pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:5.63pt;width:0pt;">&#8203;</td>
            <td style="padding:3pt 0pt 2pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3pt 0pt 2pt 0pt; min-width:34.5pt; text-align:right; white-space:nowrap;">668,424</td>
            <td style="padding:0pt;padding-left:5.63pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:10.57pt;width:0pt;">&#8203;</td>
            <td style="padding:3pt 0pt 2pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3pt 0pt 2pt 0pt; min-width:24.75pt; text-align:right; white-space:nowrap;">&#8212;</td>
            <td style="padding:0pt;padding-left:10.57pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:27.185pt;width:0pt;">&#8203;</td>
            <td style="padding:3pt 0pt 2pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3pt 0pt 2pt 0pt; min-width:7.5pt; text-align:right; white-space:nowrap;">&#8212;</td>
            <td style="padding:0pt;padding-left:27.185pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:12pt;background-color:#CCEEFF;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:1.667pt 0pt 1.333pt 0pt; width:147.68pt;white-space:normal;text-align:left;">
              <div style="margin-left:10pt; text-indent:-10pt;">
                <font style="letter-spacing:0.2pt;">Anson Investments Master Fund&#160;LP(8) </font>
              </div>
            </td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:9.525pt;width:0pt;">&#8203;</td>
            <td style="padding:1.667pt 0pt 1.333pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:1.667pt 0pt 1.333pt 0pt; min-width:24.75pt; text-align:right; white-space:nowrap;">&#8212;</td>
            <td style="padding:0pt;padding-left:9.525pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:11.98pt;width:0pt;">&#8203;</td>
            <td style="padding:1.667pt 0pt 1.333pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:1.667pt 0pt 1.333pt 0pt; min-width:24.75pt; text-align:right; white-space:nowrap;">94,045</td>
            <td style="padding:0pt;padding-left:11.98pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:5.63pt;width:0pt;">&#8203;</td>
            <td style="padding:1.667pt 0pt 1.333pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:1.667pt 0pt 1.333pt 0pt; min-width:34.5pt; text-align:right; white-space:nowrap;">2,369,796</td>
            <td style="padding:0pt;padding-left:5.63pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:10.57pt;width:0pt;">&#8203;</td>
            <td style="padding:1.667pt 0pt 1.333pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:1.667pt 0pt 1.333pt 0pt; min-width:24.75pt; text-align:right; white-space:nowrap;">&#8212;</td>
            <td style="padding:0pt;padding-left:10.57pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:27.185pt;width:0pt;">&#8203;</td>
            <td style="padding:1.667pt 0pt 1.333pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:1.667pt 0pt 1.333pt 0pt; min-width:7.5pt; text-align:right; white-space:nowrap;">&#8212;</td>
            <td style="padding:0pt;padding-left:27.185pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:10pt;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:3pt 0pt 2pt 0pt; width:147.68pt;text-align:left;">
              <div style="white-space:nowrap;">
                <font style="letter-spacing:0.2pt;">Bigger Capital Fund, LP(9) </font>
              </div>
            </td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:9.525pt;width:0pt;">&#8203;</td>
            <td style="padding:3pt 0pt 2pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3pt 0pt 2pt 0pt; min-width:24.75pt; text-align:right; white-space:nowrap;">&#8212;</td>
            <td style="padding:0pt;padding-left:9.525pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:11.98pt;width:0pt;">&#8203;</td>
            <td style="padding:3pt 0pt 2pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3pt 0pt 2pt 0pt; min-width:24.75pt; text-align:right; white-space:nowrap;">120,570</td>
            <td style="padding:0pt;padding-left:11.98pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:5.63pt;width:0pt;">&#8203;</td>
            <td style="padding:3pt 0pt 2pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3pt 0pt 2pt 0pt; min-width:34.5pt; text-align:right; white-space:nowrap;">3,038,219</td>
            <td style="padding:0pt;padding-left:5.63pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:10.57pt;width:0pt;">&#8203;</td>
            <td style="padding:3pt 0pt 2pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3pt 0pt 2pt 0pt; min-width:24.75pt; text-align:right; white-space:nowrap;">&#8212;</td>
            <td style="padding:0pt;padding-left:10.57pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:27.185pt;width:0pt;">&#8203;</td>
            <td style="padding:3pt 0pt 2pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3pt 0pt 2pt 0pt; min-width:7.5pt; text-align:right; white-space:nowrap;">&#8212;</td>
            <td style="padding:0pt;padding-left:27.185pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:10pt;background-color:#CCEEFF;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:3pt 0pt 2pt 0pt; width:147.68pt;text-align:left;">
              <div style="white-space:nowrap;">
                <font style="letter-spacing:0.2pt;">District 2 Capital Fund&#160;LP(10) </font>
              </div>
            </td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:9.525pt;width:0pt;">&#8203;</td>
            <td style="padding:3pt 0pt 2pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3pt 0pt 2pt 0pt; min-width:24.75pt; text-align:right; white-space:nowrap;">8,694</td>
            <td style="padding:0pt;padding-left:9.525pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:11.98pt;width:0pt;">&#8203;</td>
            <td style="padding:3pt 0pt 2pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3pt 0pt 2pt 0pt; min-width:24.75pt; text-align:right; white-space:nowrap;">80,380</td>
            <td style="padding:0pt;padding-left:11.98pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:5.63pt;width:0pt;">&#8203;</td>
            <td style="padding:3pt 0pt 2pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3pt 0pt 2pt 0pt; min-width:34.5pt; text-align:right; white-space:nowrap;">2,025,479</td>
            <td style="padding:0pt;padding-left:5.63pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:10.57pt;width:0pt;">&#8203;</td>
            <td style="padding:3pt 0pt 2pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3pt 0pt 2pt 0pt; min-width:24.75pt; text-align:right; white-space:nowrap;">8,694</td>
            <td style="padding:0pt;padding-left:10.57pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:27.185pt;width:0pt;">&#8203;</td>
            <td style="padding:3pt 0pt 2pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3pt 0pt 2pt 0pt; min-width:7.5pt; text-align:right; white-space:nowrap;">* </td>
            <td style="padding:0pt;padding-left:27.185pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:12pt;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:1.667pt 0pt 1.333pt 0pt; width:147.68pt;white-space:normal;text-align:left;">
              <div style="margin-left:10pt; text-indent:-10pt;">
                <font style="letter-spacing:0.2pt;">L1 Capital Global Opportunities Master Fund(11) </font>
              </div>
            </td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:9.525pt;width:0pt;">&#8203;</td>
            <td style="padding:1.667pt 0pt 1.333pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:1.667pt 0pt 1.333pt 0pt; min-width:24.75pt; text-align:right; white-space:nowrap;">&#8212;</td>
            <td style="padding:0pt;padding-left:9.525pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:11.98pt;width:0pt;">&#8203;</td>
            <td style="padding:1.667pt 0pt 1.333pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:1.667pt 0pt 1.333pt 0pt; min-width:24.75pt; text-align:right; white-space:nowrap;">120,570</td>
            <td style="padding:0pt;padding-left:11.98pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:5.63pt;width:0pt;">&#8203;</td>
            <td style="padding:1.667pt 0pt 1.333pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:1.667pt 0pt 1.333pt 0pt; min-width:34.5pt; text-align:right; white-space:nowrap;">3,038,219</td>
            <td style="padding:0pt;padding-left:5.63pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:10.57pt;width:0pt;">&#8203;</td>
            <td style="padding:1.667pt 0pt 1.333pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:1.667pt 0pt 1.333pt 0pt; min-width:24.75pt; text-align:right; white-space:nowrap;">&#8212;</td>
            <td style="padding:0pt;padding-left:10.57pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:27.185pt;width:0pt;">&#8203;</td>
            <td style="padding:1.667pt 0pt 1.333pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:1.667pt 0pt 1.333pt 0pt; min-width:7.5pt; text-align:right; white-space:nowrap;">&#8212;</td>
            <td style="padding:0pt;padding-left:27.185pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:12pt;background-color:#CCEEFF;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="border-bottom:1px solid #CCEEFF;padding:1.667pt 0pt 1.833pt 0pt; width:147.68pt;white-space:normal;text-align:left;">
              <div style="margin-left:10pt; text-indent:-10pt;">
                <font style="letter-spacing:0.2pt;">Sabby Volatility Warrant Master Fund, Ltd.(12) </font>
              </div>
            </td>
            <td style="padding:0pt;border-bottom:1px solid #CCEEFF; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #CCEEFF; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:9.525pt;width:0pt;border-bottom:1px solid #CCEEFF;">&#8203;</td>
            <td style="padding:1.667pt 0pt 1.833pt 0pt;border-bottom:1px solid #000000; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:1.667pt 0pt 1.833pt 0pt;border-bottom:1px solid #000000; min-width:24.75pt; text-align:right; white-space:nowrap;">154,855</td>
            <td style="padding:0pt;padding-left:9.525pt;width:0pt;border-bottom:1px solid #CCEEFF;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #CCEEFF; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #CCEEFF; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:11.98pt;width:0pt;border-bottom:1px solid #CCEEFF;">&#8203;</td>
            <td style="padding:1.667pt 0pt 1.833pt 0pt;border-bottom:1px solid #000000; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:1.667pt 0pt 1.833pt 0pt;border-bottom:1px solid #000000; min-width:24.75pt; text-align:right; white-space:nowrap;">200,949</td>
            <td style="padding:0pt;padding-left:11.98pt;width:0pt;border-bottom:1px solid #CCEEFF;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #CCEEFF; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #CCEEFF; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:5.63pt;width:0pt;border-bottom:1px solid #CCEEFF;">&#8203;</td>
            <td style="padding:1.667pt 0pt 1.833pt 0pt;border-bottom:1px solid #000000; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:1.667pt 0pt 1.833pt 0pt;border-bottom:1px solid #000000; min-width:34.5pt; text-align:right; white-space:nowrap;">5,063,672</td>
            <td style="padding:0pt;padding-left:5.63pt;width:0pt;border-bottom:1px solid #CCEEFF;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #CCEEFF; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #CCEEFF; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:10.57pt;width:0pt;border-bottom:1px solid #CCEEFF;">&#8203;</td>
            <td style="padding:1.667pt 0pt 1.833pt 0pt;border-bottom:1px solid #000000; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:1.667pt 0pt 1.833pt 0pt;border-bottom:1px solid #000000; min-width:24.75pt; text-align:right; white-space:nowrap;">154,855</td>
            <td style="padding:0pt;padding-left:10.57pt;width:0pt;border-bottom:1px solid #CCEEFF;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #CCEEFF; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #CCEEFF; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:27.185pt;width:0pt;border-bottom:1px solid #CCEEFF;">&#8203;</td>
            <td style="padding:1.667pt 0pt 1.833pt 0pt;border-bottom:1px solid #000000; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:1.667pt 0pt 1.833pt 0pt;border-bottom:1px solid #000000; min-width:7.5pt; text-align:right; white-space:nowrap;">* </td>
            <td style="padding:0pt;padding-left:27.185pt;width:0pt;border-bottom:1px solid #CCEEFF;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #CCEEFF; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:10pt;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="border-bottom:1px solid #000000;padding:2.75pt 0pt 2.5pt 0pt; width:147.68pt;text-align:left;">
              <div style="font-weight:bold;">
                <font style="letter-spacing:-0.2pt;">Total</font>
              </div>
            </td>
            <td style="padding:0pt;border-bottom:1px solid #000000; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #000000; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:9.525pt;width:0pt;border-bottom:1px solid #000000;">&#8203;</td>
            <td style="padding:2.75pt 0pt 2.5pt 0pt;border-bottom:1px solid #000000; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:2.75pt 0pt 2.5pt 0pt;border-bottom:1px solid #000000; min-width:24.75pt; text-align:right; white-space:nowrap;">163,549</td>
            <td style="padding:0pt;padding-left:9.525pt;width:0pt;border-bottom:1px solid #000000;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #000000; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #000000; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:11.98pt;width:0pt;border-bottom:1px solid #000000;">&#8203;</td>
            <td style="padding:2.75pt 0pt 2.5pt 0pt;border-bottom:1px solid #000000; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:2.75pt 0pt 2.5pt 0pt;border-bottom:1px solid #000000; min-width:24.75pt; text-align:right; white-space:nowrap;">643,040</td>
            <td style="padding:0pt;padding-left:11.98pt;width:0pt;border-bottom:1px solid #000000;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #000000; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #000000; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:5.63pt;width:0pt;border-bottom:1px solid #000000;">&#8203;</td>
            <td style="padding:2.75pt 0pt 2.5pt 0pt;border-bottom:1px solid #000000; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:2.75pt 0pt 2.5pt 0pt;border-bottom:1px solid #000000; min-width:34.5pt; text-align:right; white-space:nowrap;">16,203,809</td>
            <td style="padding:0pt;padding-left:5.63pt;width:0pt;border-bottom:1px solid #000000;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #000000; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #000000; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:10.57pt;width:0pt;border-bottom:1px solid #000000;">&#8203;</td>
            <td style="padding:2.75pt 0pt 2.5pt 0pt;border-bottom:1px solid #000000; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:2.75pt 0pt 2.5pt 0pt;border-bottom:1px solid #000000; min-width:24.75pt; text-align:right; white-space:nowrap;">163,549</td>
            <td style="padding:0pt;padding-left:10.57pt;width:0pt;border-bottom:1px solid #000000;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #000000; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #000000; width:2.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:27.185pt;width:0pt;border-bottom:1px solid #000000;">&#8203;</td>
            <td style="padding:2.75pt 0pt 2.5pt 0pt;border-bottom:1px solid #000000; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:2.75pt 0pt 2.5pt 0pt;border-bottom:1px solid #000000; min-width:7.5pt; text-align:right; white-space:nowrap;">*</td>
            <td style="padding:0pt;padding-left:27.185pt;width:0pt;border-bottom:1px solid #000000;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #000000; width:0pt;">&#8203;</td>
          </tr>
        </table>
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        <div style=" float:left; line-height:12pt; margin-top:5.65pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;font-size:7.5pt;">
          <font style=" position:relative; bottom:4.25pt;letter-spacing:0.15pt;">*</font>
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        <div style=" margin-top:5.65pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;font-size:7.5pt;">
          <!--blacklining:none;-->
          <font style="font-size:10pt;letter-spacing:0.2pt;">Represents less than 1%</font>
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        <div style=" float:left; line-height:12pt; margin-top:3.9pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style=" position:relative; bottom:4.25pt;font-size:7.5pt;letter-spacing:0.15pt;">1)</font>
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          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">The principal business address and address for notice to the Selling Stockholders is the address set forth in our books and records. </font>
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        <div style=" float:left; line-height:12pt; margin-top:3.9pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style=" position:relative; bottom:4.25pt;font-size:7.5pt;letter-spacing:0.15pt;">2)</font>
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        <div style=" margin-top:3.9pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">This includes, for each Selling Stockholder, any shares of Common Stock beneficially owned by such holder acquired in one or more transactions separate from and unrelated to the holder&#8217;s ownership of any of our Common Stock. </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:3.9pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style=" position:relative; bottom:4.25pt;font-size:7.5pt;letter-spacing:0.15pt;">3)</font>
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        <div style=" margin-top:3.9pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">This includes, for each Selling Stockholder, PIPE Common Stock shares and PIPE PFW Shares being sold hereunder. </font>
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        <div style=" float:left; line-height:12pt; margin-top:3.9pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style=" position:relative; bottom:4.25pt;font-size:7.5pt;letter-spacing:0.15pt;">4)</font>
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        <div style=" margin-top:3.9pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">This includes, for each Selling Stockholder, the maximum amount of Common Stock that can be issued upon exercise of the Warrants after factoring in the anti-dilution feature. </font>
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        <div style=" float:left; line-height:12pt; margin-top:3.9pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style=" position:relative; bottom:4.25pt;font-size:7.5pt;letter-spacing:0.15pt;">5)</font>
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          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">Assumes the Selling Stockholders sell all of the Resale Shares being offered by this prospectus. </font>
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        <div style=" float:left; line-height:12pt; margin-top:3.9pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style=" position:relative; bottom:4.25pt;font-size:7.5pt;letter-spacing:0.15pt;">6)</font>
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        <div style=" margin-top:3.9pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">Percentage calculated based upon the assumption that the Selling Stockholders sell all of the Resale Shares offered by this prospectus. </font>
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        <div style=" float:left; line-height:12pt; margin-top:3.9pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style=" position:relative; bottom:4.25pt;font-size:7.5pt;letter-spacing:0.15pt;">7)</font>
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          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">Based on information provided by Anson East Master Fund&#160;LP, Anson Advisors Inc and Anson Funds Management LP, the Co-Investment Advisers of Anson East Master Fund&#160;LP (&#8220;Anson&#8221;), hold voting and dispositive power over the securities which include 15,267 shares of Common Stock, 11,259&#160;Pre-Funded Warrants, and 668,424 Common Warrants held by Anson. Tony Moore is the managing member of Anson Management GP LLC, which is the general partner of Anson Funds Management LP. Moez Kassam and Amin Nathoo are directors of Anson Advisors Inc. Mr.&#160;Moore, Mr.&#160;Kassam and Mr.&#160;Nathoo each disclaim beneficial ownership of these Common Shares except to the extent of their pecuniary interest therein. </font>
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        <div style="text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">&#160;</font>
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      <div style="margin-top:2pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
        <div style="width:456pt;">
          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
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          <font style="letter-spacing:0.2pt;">21</font>&#8203;</div>
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        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a>
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      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:6pt; width:456pt; line-height:14pt;font-size:12pt;">
          <font style="letter-spacing:0.24pt;">T</font><font style="text-transform:lowercase;letter-spacing:0.24pt;">HE</font><font style="letter-spacing:0.24pt;"> S</font><font style="text-transform:lowercase;letter-spacing:0.24pt;">ELLING</font><font style="letter-spacing:0.24pt;"> S</font><font style="text-transform:lowercase;letter-spacing:0.24pt;">TOCKHOLDERS</font>
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        <div style="margin-top:5.833pt; width:456pt;">
          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
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      <div style="margin-top:6pt;margin-left:69.66pt;width:456pt;">
        <div style=" float:left; line-height:12pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style=" position:relative; bottom:4.25pt;font-size:7.5pt;letter-spacing:0.15pt;">8)</font>
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          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">Based on information provided by Anson Investments Master Fund&#160;LP, Anson Advisors Inc and Anson Funds Management LP, the Co-Investment Advisers of Anson Investments Master Fund&#160;LP (&#8220;Anson&#8221;), hold voting and dispositive power over the securities which include 54,127 shares of Common Stock, 39,917 Pre-Funded Warrants, and 2,369,796 Common Warrants held by Anson. Tony Moore is the managing member of Anson Management GP LLC, which is the general partner of Anson Funds Management LP. Moez Kassam and Amin Nathoo are directors of Anson Advisors Inc. Mr.&#160;Moore, Mr.&#160;Kassam and Mr.&#160;Nathoo each disclaim beneficial ownership of these Common Shares except to the extent of their pecuniary interest therein. The principal business address of Anson is Maples Corporate Services Limited, PO Box 309, Ugland House, Grand Cayman, KY1-1104, Cayman Islands. </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:3.91pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style=" position:relative; bottom:4.25pt;font-size:7.5pt;letter-spacing:0.15pt;">9)</font>
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        <div style=" margin-top:3.91pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">Based on information provided by Bigger Capital Fund, LP, Michael Bigger is the controlling person of the securities which include 34,545 shares of Common Stock, 86,024 Pre-Funded Warrants and 3,038,219 Common Warrants held by Bigger Capital Fund, LP. </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:4pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style=" position:relative; bottom:4.25pt;font-size:7.5pt;letter-spacing:0.15pt;">10)</font>
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        <div style=" margin-top:4pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">Based on information provided by District 2 Capital Fund&#160;LP, Michael Bigger is the controlling person of the securities which include 34,546 shares of Common Stock, 45,834 Pre-Funded Warrants, 2,025,479 Common Warrants and 8,694 warrants to purchase common stock exercisable within 60&#160;days of December&#160;2, 2024, held by District 2 Capital Fund&#160;LP. </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:4pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style=" position:relative; bottom:4.25pt;font-size:7.5pt;letter-spacing:0.15pt;">11)</font>
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        <div style=" margin-top:4pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">Based on information provided by L1 Capital Global Opportunities Master Fund, David Feldman and Joel Arber are the controlling persons of the securities which include 34,546 shares of Common Stock, 86,024 Pre-Funded Warrants, and 3,038,219 Common Warrants held by L1 Capital Global Opportunities Master Fund. </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:4pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style=" position:relative; bottom:4.25pt;font-size:7.5pt;letter-spacing:0.15pt;">12)</font>
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        <div style=" margin-top:4pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">Based on information provided by Sabby Volatility Warrant Master Fund, Ltd., Sabby Management, LLC is the investment manager of Sabby Volatility Warrant Master Fund, Ltd. and shares voting and investment power with respect to these shares in this capacity. As manager of Sabby Management, LLC, Hal Mintz also shares voting and investment power on behalf of Sabby Volatility Warrant Master Fund, Ltd. Each of Sabby Management, LLC and Hal Mintz disclaims beneficial ownership over the securities listed except to the extent of their pecuniary interest therein. Sabby Volatility Warrant Master Fund, Ltd. holds 200,949 Pre-Funded Warrants, 5,063,672 Comon Warrants and 154,855 warrants to purchase common stock exercisable within 60&#160;days of December&#160;2, 2024. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:14pt;font-weight:bold;font-size:12pt;">
          <font style="letter-spacing:-0.24pt;">Relationship with the Selling Stockholders</font><font style="font-weight:normal;letter-spacing:0.24pt;"> </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;font-style:italic;">
          <font style="letter-spacing:0.2pt;">Registration Rights Agreement</font><font style="font-style:normal;letter-spacing:0.2pt;"> </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">Pursuant to the PIPE SPA, we agreed to (i)&#160;prepare and file with the SEC the registration statement of which this prospectus forms a part to permit the resale of the Resale Shares and (ii)&#160;subject to certain exceptions, to use reasonable best efforts to keep such registration statement effective under the Securities Act until (x)&#160;all Resale Shares the offer and resale of which are registered by the registration statement have been sold, transferred or otherwise disposed of by the Selling Stockholders, (y)&#160;the Resale Shares are sold, transferred or otherwise disposed of pursuant to Rule&#160;144 of the Securities Act, or (z)&#160;the Resale Shares have become eligible for sale by the Selling Stockholders pursuant to Rule&#160;144 without any restriction on the volume or manner of such sale and all restrictive legends and stop transfer instructions have been removed with respect to all book entries representing the Resale Shares. </font>
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          <font style="letter-spacing:0.2pt;">We have also agreed, among other things, to indemnify the Selling Stockholders and their officers, directors, members, employees and agents, successors and assigns, and any person who controls any of the Selling Stockholders (within the meaning of the Securities Act or the Exchange Act) from all losses and liabilities arising out of or relating to any untrue statement or alleged untrue statement or omission or alleged omission of material fact in this prospectus or the registration statement of which this prospectus forms a part. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;font-style:italic;">
          <font style="letter-spacing:0.2pt;">PIPE Series&#160;C and Series&#160;D Warrants</font><font style="font-style:normal;letter-spacing:0.2pt;"> </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">On November&#160;26, 2024, we entered into the PIPE SPA in connection with which we issued to the Selling Stockholders our Series&#160;C Warrants and Series&#160;D Warrants. Each Series&#160;C Warrant has an initial exercise price per share of $15.675 and will be exercisable beginning on the date on which Stockholder Approval (as </font>
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          <font style="letter-spacing:0.2pt;">&#160;</font>
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        <div style="width:456pt;">
          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
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        <div style="margin-top:3pt; width:456pt; line-height:13pt;">
          <font style="letter-spacing:0.2pt;">22</font>
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        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a>
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      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:6pt; width:456pt; line-height:14pt;font-size:12pt;">
          <font style="letter-spacing:0.24pt;">T</font><font style="text-transform:lowercase;letter-spacing:0.24pt;">HE</font><font style="letter-spacing:0.24pt;"> S</font><font style="text-transform:lowercase;letter-spacing:0.24pt;">ELLING</font><font style="letter-spacing:0.24pt;"> S</font><font style="text-transform:lowercase;letter-spacing:0.24pt;">TOCKHOLDERS</font>
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          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
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        <div style="width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">defined below) is received and deemed effective (the &#8220;</font><font style=" text-decoration:underline #000000 solid;letter-spacing:0.2pt;">Initial Exercise Date</font><font style="letter-spacing:0.2pt;">&#8221; or the &#8220;</font><font style=" text-decoration:underline #000000 solid;letter-spacing:0.2pt;">Stockholder Approval Date</font><font style="letter-spacing:0.2pt;">&#8221;). The Series&#160;C Warrants will expire on the five-year anniversary of the Initial Exercise Date. Additionally, the Series&#160;C Warrants provide for an adjustment to the exercise price and number of shares underlying such the Series&#160;C Warrants upon the Company&#8217;s issuance of common shares or common share equivalents at a price per share that is less than the exercise price of the Series&#160;C Warrants, subject to a floor price of $2.4882 per share (the &#8220;</font><font style=" text-decoration:underline #000000 solid;letter-spacing:0.2pt;">Floor Price</font><font style="letter-spacing:0.2pt;">&#8221;). The Series&#160;D Warrants have an initial exercise price per share of $15.675 and will be exercisable beginning on the Initial Exercise Date. The Series&#160;D Warrants will expire two and one-half&#160;years after the Initial Exercise Date. Under an alternative cashless exchange provision in the Series&#160;D Warrants, holders thereof have the right to receive an aggregate number of shares equal to the product of (i)&#160;the aggregate number of common shares that would be issuable upon a cash exercise of the Series&#160;D Warrants and (ii)&#160;3.0. In addition, on the 11th trading day following each of (i)&#160;the later of (A)&#160;the Stockholder Approval Date and (B)&#160;the Effective Date (as that term is defined in the PIPE SPA) and (ii)&#160;each subsequent date that a Registration Statement (as that term is defined in the PIPE SPA) is declared effective by the Securities and Exchange Commission, if any (each such trading day, a &#8220;</font><font style=" text-decoration:underline #000000 solid;letter-spacing:0.2pt;">Reset Date</font><font style="letter-spacing:0.2pt;">&#8221;), the Series&#160;C Warrants and the Series&#160;D Warrants contain a reset of the exercise price to a price equal to the lesser of (i)&#160;the then applicable exercise price and (ii)&#160;the greater of the Floor Price and the lowest volume weighted average price for the ten trading days immediately preceding the Reset Date. Upon such reset of the exercise price, the number of shares issuable under the Common Warrant shall be increased such that the aggregate exercise price of the Common Warrant shall remain unchanged following such reset. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">The issuance of shares of Common Stock upon exercise of the Common Warrants is subject to stockholder approval under applicable rules and regulations of The Nasdaq Stock Market LLC (&#8220;</font><font style=" text-decoration:underline #000000 solid;letter-spacing:0.2pt;">Nasdaq</font><font style="letter-spacing:0.2pt;">&#8221;) (&#8220;</font><font style=" text-decoration:underline #000000 solid;letter-spacing:0.2pt;">Stockholder Approval</font><font style="letter-spacing:0.2pt;">&#8221; and the date on which Stockholder Approval is received and deemed effective, the &#8220;</font><font style=" text-decoration:underline #000000 solid;letter-spacing:0.2pt;">Stockholder Approval Date</font><font style="letter-spacing:0.2pt;">&#8221;). The Company intends to hold a shareholder meeting to obtain Stockholder Approval within 70&#160;days following the closing of the PIPE. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">A holder of Resale Securities will not have the right to exercise any portion of the Common Warrants or PIPE PFWs if the holder (together with its affiliates) would beneficially own in excess of 4.99% or 9.99%, as applicable, of the number of shares of Common Stock outstanding immediately after giving effect to the exercise, as such&#160;percentage ownership is determined in accordance with the terms of the Common Warrants or the PIPE PFWs, respectively.</font>
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          <font style="letter-spacing:0.2pt;">&#160;</font>
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          <font style="letter-spacing:0.2pt;">23</font>&#8203;</div>
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        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a><a name="tDOSB">&#8203;</a>
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      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
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          <font style="letter-spacing:0.24pt;">&#160;</font>
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      <div style="margin-top:6pt;margin-left:69.66pt;width:456pt;">
        <div style="text-align:center; width:456pt; line-height:20pt;font-weight:bold;font-size:18pt;">
          <font style="letter-spacing:-0.36pt;">Description of Securities Being Registered</font><font style="font-weight:normal;letter-spacing:0.36pt;"> </font>
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        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:0.2pt;">We are registering the resale of (i)&#160;173,033 shares of our common stock, par value $0.0001 per share, (&#8220;Common Stock&#8221;) issued in a private placement of our securities (the &#8220;PIPE&#8221;), (ii)&#160;470,007 shares of Common Stock (the &#8220;PIPE PFW Shares&#8221;) issuable upon exercise of pre-funded warrants (each, a &#8220;PIPE PFW&#8221;), (iii)&#160;up to 4,050,951 common shares underlying the Series&#160;C Common Warrants and (iv)&#160;up to 12,152,853 common shares underlying the Series&#160;D Common Warrants issued in the PIPE and issuable in connection with the Warrants. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:14pt;font-weight:bold;font-size:12pt;">
          <font style="letter-spacing:-0.24pt;">Common Stock</font><font style="font-weight:normal;letter-spacing:0.24pt;"> </font>
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        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:0.2pt;">The Company&#8217;s Certificate of Incorporation, as amended, authorizes the Company to issue up to 290,000,000 shares of Common Stock. Our Common Stock is traded on The Nasdaq Capital Market under the symbol &#8220;RNAZ.&#8221; </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">The terms, rights, preference and privileges of the Common Stock are as follows: </font>
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        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="font-style:italic;letter-spacing:0.2pt;">Voting Rights.&nbsp;&nbsp;&nbsp;</font><font style="letter-spacing:0.2pt;">Each holder of Common Stock is entitled to one vote per share of Common Stock held on all matters submitted to a vote of the stockholders, including the election of directors. The Company&#8217;s certificate of incorporation and bylaws do not provide for cumulative voting rights. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="font-style:italic;letter-spacing:0.2pt;">Dividends.&nbsp;&nbsp;&nbsp;</font><font style="letter-spacing:0.2pt;">Subject to preferences that may be applicable to any then-outstanding preferred stock, the holders of the Company&#8217;s outstanding shares of Common Stock are entitled to receive dividends, if any, as may be declared from time to time by the Company&#8217;s Board of Directors out of legally available funds. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="font-style:italic;letter-spacing:0.2pt;">Liquidation.&nbsp;&nbsp;&nbsp;</font><font style="letter-spacing:0.2pt;">In the event of the Company&#8217;s liquidation, dissolution or winding up, holders of Common Stock will be entitled to share ratably in the net assets legally available for distribution to stockholders after the payment of all of the Company&#8217;s debts and other liabilities, subject to the satisfaction of any liquidation preference granted to the holders of any outstanding shares of preferred stock. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="font-style:italic;letter-spacing:0.2pt;">Rights and Preference.&nbsp;&nbsp;&nbsp;</font><font style="letter-spacing:0.2pt;">Holders of the Company&#8217;s Common Stock have no preemptive, conversion or subscription rights, and there is no redemption or sinking fund provisions applicable to our Common Stock. The rights, preferences and privileges of the holders of Common Stock are subject to, and may be adversely affected by, the rights of the holders of shares of any series of the Company&#8217;s preferred stock that are or may be issued. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="font-style:italic;letter-spacing:0.2pt;">Fully Paid and Nonassessable.&nbsp;&nbsp;&nbsp;</font><font style="letter-spacing:0.2pt;">All of the Company&#8217;s outstanding shares of Common Stock are fully paid and nonassessable. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="font-style:italic;letter-spacing:0.2pt;">Registration Rights.&nbsp;&nbsp;&nbsp;</font><font style="letter-spacing:0.2pt;">Pursuant to the PIPE SPA, we agreed to (i)&#160;prepare and file with the SEC the registration statement of which this prospectus forms a part to permit the resale of the Resale Shares and (ii)&#160;subject to certain exceptions, to use reasonable best efforts to keep such registration statement effective under the Securities Act until (x)&#160;all Resale Shares the offer and resale of which are registered by the registration statement have been sold, transferred or otherwise disposed of by the Selling Stockholders, (y)&#160;the Resale Shares are sold, transferred or otherwise disposed of pursuant to Rule&#160;144 of the Securities Act, or (z)&#160;the Resale Shares have become eligible for sale by the Selling Stockholders pursuant to Rule&#160;144 without any restriction on the volume or manner of such sale and all restrictive legends and stop transfer instructions have been removed with respect to all book entries representing the Resale Shares. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:14pt;font-weight:bold;font-size:12pt;">
          <font style="letter-spacing:-0.24pt;">Warrants Held by the Selling Stockholders</font><font style="font-weight:normal;letter-spacing:0.24pt;"> </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;font-style:italic;">
          <font style="letter-spacing:0.2pt;">Pre-Funded Warrants</font><font style="font-style:normal;letter-spacing:0.2pt;"> </font>
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        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:0.2pt;">The following is a summary of certain terms and provisions of the PIPE PFWs. This summary is not complete and is subject to, and qualified in its entirety by, the provisions of the PIPE PFW, the form of </font>
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      <div style="margin-top:2.00000000000002pt;height:12pt;margin-left:69.66pt;width:456pt;">
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          <font style="letter-spacing:0.2pt;">&#160;</font>
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          <font style="letter-spacing:0.2pt;">24</font>
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      <div style="padding:0pt;margin:0pt;font-family:calibri, arial, sans-serif;font-weight:normal;font-style:normal;font-size:8pt;line-height:8pt;">
        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a>
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      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:6pt; width:456pt; line-height:14pt;font-size:12pt;">
          <font style="letter-spacing:0.24pt;">Description of Securities Being Registered</font>
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          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
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          <font style="letter-spacing:0.2pt;">which is filed as an exhibit to the registration statement of which this prospectus forms a part. Prospective investors should carefully review the terms and provisions of the form of PIPE PFW for a complete description of the terms and conditions of the PIPE PFWs. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="font-style:italic;letter-spacing:0.2pt;">Duration and Exercise Price.&nbsp;&nbsp;&nbsp;</font><font style="letter-spacing:0.2pt;">Each PIPE PFW has an initial exercise price per share equal to $0.0001. The PIPE PFWs are immediately exercisable and may be exercised at any time. There is no expiration date for the PIPE PFWs. The exercise price and number of shares of common stock issuable upon exercise of the PIPE PFWs is subject to appropriate adjustment in the event of stock dividends, stock splits, reorganizations or similar events affecting our common stock and the exercise price. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="font-style:italic;letter-spacing:0.2pt;">Exercisability.&nbsp;&nbsp;&nbsp;</font><font style="letter-spacing:0.2pt;">The PIPE PFWs are exercisable, at the option of each holder, in whole or in part, by delivering to us a duly executed exercise notice accompanied by payment in full for the number of shares of our common stock purchased upon such exercise (except in the case of a cashless exercise as discussed below). A holder (together with its affiliates) may not exercise any portion of the PIPE PFWs to the extent that the holder would own more than 4.99% (or, at the election of the holder prior to the issuance of any PIPE PFWs, 9.99%) of the outstanding shares of common stock immediately after exercise. Any holder may increase such&#160;percentage to any&#160;percentage not in excess of 9.99% upon at least 61&#160;days&#8217; prior notice to us. No fractional shares of common stock will be issued in connection with the exercise of a PIPE PFW. In lieu of fractional shares of common stock, we will pay the holder an amount in cash equal to the fractional amount multiplied by the exercise price of such PIPE PFW or round up to the next whole share. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="font-style:italic;letter-spacing:0.2pt;">Cashless Exercise.&nbsp;&nbsp;&nbsp;</font><font style="letter-spacing:0.2pt;">In lieu of making the cash payment of the aggregate exercise price otherwise contemplated to be made to us upon such exercise, the holder may elect instead to receive upon such exercise (either in whole or in part) the net number of shares of common stock determined according to a formula set forth in the PIPE PFWs. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="font-style:italic;letter-spacing:0.2pt;">Fundamental Transaction.&nbsp;&nbsp;&nbsp;</font><font style="letter-spacing:0.2pt;">In the event of a fundamental transaction, as described in the PIPE PFWs and generally including any reorganization, recapitalization or reclassification of our common stock, the sale, transfer or other disposition of all or substantially all of our properties or assets, our consolidation or merger with or into another person, the acquisition of more than 50% of our outstanding shares of common stock, or any person or group becoming the beneficial owner of 50% of the voting power represented by our outstanding shares of common stock, the holders of the PIPE PFWs will be entitled to receive upon exercise of the PIPE PFWs the kind and amount of securities, cash or other property that the holders would have received had they exercised the PIPE PFWs immediately prior to such fundamental transaction. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="font-style:italic;letter-spacing:0.2pt;">Transferability.&nbsp;&nbsp;&nbsp;</font><font style="letter-spacing:0.2pt;">Subject to applicable laws, a PIPE PFW may be transferred at the option of the holder upon surrender of the PIPE PFW to us together with the appropriate instruments of transfer. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="font-style:italic;letter-spacing:0.2pt;">No Exchange Listing.&nbsp;&nbsp;&nbsp;</font><font style="letter-spacing:0.2pt;">We do not intend to list the PIPE PFWs on any securities exchange or nationally recognized trading system. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="font-style:italic;letter-spacing:0.2pt;">No Rights as a Stockholder.&nbsp;&nbsp;&nbsp;</font><font style="letter-spacing:0.2pt;">Except as otherwise provided in the PIPE PFWs or by virtue of such holder&#8217;s ownership of shares of our common stock, the holders of the PIPE PFWs do not have the rights or privileges of holders of our common stock, including any voting rights. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;font-style:italic;">
          <font style="letter-spacing:0.2pt;">Series&#160;C Warrants</font><font style="font-style:normal;letter-spacing:0.2pt;"> </font>
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        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:0.2pt;">The following is a summary of certain terms and provisions of the Series&#160;C Warrants. This summary is not complete and is subject to, and qualified in its entirety by, the provisions of the Series&#160;C Warrants, the form of which is filed as an exhibit to the registration statement of which this prospectus forms a part. Prospective investors should carefully review the terms and provisions of the form of Series&#160;C Warrants for a complete description of the terms and conditions of the Series&#160;C Warrants. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="font-style:italic;letter-spacing:0.2pt;">Duration and Exercise Price.&nbsp;&nbsp;&nbsp;</font><font style="letter-spacing:0.2pt;">Each Series&#160;C Warrant has an initial exercise price per share equal to $15.675. The Series&#160;C Warrants may be exercised at any time after Shareholder Approval for a period of five&#160;years. The exercise price and number of shares of common stock issuable upon exercise of the Series&#160;C </font>
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      <div style="margin-top:2.00000000000002pt;height:12pt;margin-left:69.66pt;width:456pt;">
        <div style="text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">&#160;</font>
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          <font style="letter-spacing:0.2pt;">25</font>&#8203;</div>
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        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a>
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      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:6pt; width:456pt; line-height:14pt;font-size:12pt;">
          <font style="letter-spacing:0.24pt;">Description of Securities Being Registered</font>
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        <div style="margin-top:5.833pt; width:456pt;">
          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
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        <div style="width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">Warrants is subject to appropriate adjustment in the event of (i)&#160;stock dividends, stock splits, stock combinations, reclassifications, reorganizations or similar events, or (ii)&#160;upon any distributions of assets, including cash, stock or other property to our stockholders, or (iii)&#160;if, while the Series&#160;C Warrants are outstanding, the Company engages in any transaction involving the issuance or sale of shares of common stock or equivalent securities at an effective price per share less than the then exercise price of the Series&#160;C Warrants, subject to a floor price of $2.4882 per share. In addition, on the 11th trading day following each of (i)&#160;the later of (A)&#160;the Stockholder Approval Date and (B)&#160;the Effective Date (as that term is defined in the SPA) and (ii)&#160;each subsequent date that a Registration Statement (as that term is defined in the SPA) is declared effective by the Securities and Exchange Commission, if any (each such trading day, a &#8220;</font><font style=" text-decoration:underline #000000 solid;letter-spacing:0.2pt;">Reset Date</font><font style="letter-spacing:0.2pt;">&#8221;), the Series&#160;C Warrants contain a reset of the exercise price to a price equal to the lesser of (i)&#160;the then applicable exercise price and (ii)&#160;the greater of the Floor Price and the lowest volume weighted average price for the ten trading days immediately preceding the Reset Date. Upon such reset of the exercise price, the number of shares issuable under the Series&#160;C Warrants shall be increased such that the aggregate exercise price of the Series&#160;C Warrants shall remain unchanged following such reset. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="font-style:italic;letter-spacing:0.2pt;">Exercise Limitation.&nbsp;&nbsp;&nbsp;</font><font style="letter-spacing:0.2pt;">A holder will not have the right to exercise any portion of the Series&#160;C Warrants if the holder (together with its affiliates and certain related parties) would beneficially own in excess of 4.99% of the number of shares of our Common Stock outstanding immediately after giving effect to that proposed exercise, as such&#160;percentage ownership is determined in accordance with the terms of the Series&#160;C Warrants. However, any holder may increase or decrease such&#160;percentage to any other&#160;percentage not in excess of 9.99%, provided that any increase in such&#160;percentage shall not be effective until 61&#160;days following notice from the holder to us. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="font-style:italic;letter-spacing:0.2pt;">Transferability.&nbsp;&nbsp;&nbsp;</font><font style="letter-spacing:0.2pt;">Subject to applicable laws, the Series&#160;C Warrants may be offered for sale, sold, transferred or assigned without our consent. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="font-style:italic;letter-spacing:0.2pt;">Exchange Listing.&nbsp;&nbsp;&nbsp;</font><font style="letter-spacing:0.2pt;">We do not intend to list the Series&#160;C Warrants on any securities exchange or nationally recognized trading system. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="font-style:italic;letter-spacing:0.2pt;">Fundamental Transactions.&nbsp;&nbsp;&nbsp;</font><font style="letter-spacing:0.2pt;">In the event of a fundamental transaction, as described in the Series&#160;C Warrants and generally including any reorganization, recapitalization or reclassification of our Common Stock, the sale, transfer or other disposition of all or substantially all of our properties or assets, our consolidation or merger with or into another person, the acquisition of more than 50% of our outstanding Common Stock, or any person or group becoming the beneficial owner of 50% or more of the voting power represented by our outstanding Common Stock, the holders of the Series&#160;C Warrants will be entitled to receive upon exercise of the Series&#160;C Warrants the kind and amount of securities, cash or other property that the holders would have received had they exercised the Series&#160;C Warrants immediately prior to such fundamental transaction. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="font-style:italic;letter-spacing:0.2pt;">Rights as a Stockholder.&nbsp;&nbsp;&nbsp;</font><font style="letter-spacing:0.2pt;">Except as otherwise provided in the Series&#160;C Warrants or by virtue of such holder&#8217;s ownership of shares of our Common Stock, the holder of a Series&#160;C Warrant does not have the rights or privileges of a holder of our Common Stock, including any voting rights, until the holder exercises the Series&#160;C Warrant. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="font-style:italic;letter-spacing:0.2pt;">Registration Rights.&nbsp;&nbsp;&nbsp;</font><font style="letter-spacing:0.2pt;">Pursuant to the PIPE SPA, we agreed to (i)&#160;prepare and file with the SEC the registration statement of which this prospectus forms a part to permit the resale of the Resale Shares and (ii)&#160;subject to certain exceptions, to use reasonable best efforts to keep such registration statement effective under the Securities Act until (x)&#160;all Resale Shares the offer and resale of which are registered by the registration statement have been sold, transferred or otherwise disposed of by the Selling Stockholders, (y)&#160;the Resale Shares are sold, transferred or otherwise disposed of pursuant to Rule&#160;144 of the Securities Act, or (z)&#160;the Resale Shares have become eligible for sale by the Selling Stockholders pursuant to Rule&#160;144 without any restriction on the volume or manner of such sale and all restrictive legends and stop transfer instructions have been removed with respect to all book entries representing the Resale Shares. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="font-style:italic;letter-spacing:0.2pt;">Governing Law.&nbsp;&nbsp;&nbsp;</font><font style="letter-spacing:0.2pt;">The Series&#160;C Warrants are governed by New York law. </font>
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          <font style="letter-spacing:0.2pt;">&#160;</font>
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          <font style="letter-spacing:0.2pt;">26</font>
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        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a>
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        <div style="margin-top:6pt; width:456pt; line-height:14pt;font-size:12pt;">
          <font style="letter-spacing:0.24pt;">Description of Securities Being Registered</font>
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          <font style="letter-spacing:0.2pt;">Series&#160;D Warrants</font><font style="font-style:normal;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:0.2pt;">The following is a summary of certain terms and provisions of the Series&#160;D Warrants. This summary is not complete and is subject to, and qualified in its entirety by, the provisions of the Series&#160;D Warrants, the form of which is filed as an exhibit to the registration statement of which this prospectus forms a part. Prospective investors should carefully review the terms and provisions of the form of Series&#160;D Warrants for a complete description of the terms and conditions of the Series&#160;D Warrants. </font>
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          <font style="font-style:italic;letter-spacing:0.2pt;">Duration and Exercise Price.&nbsp;&nbsp;&nbsp;</font><font style="letter-spacing:0.2pt;">Each Series&#160;D Warrant has an initial exercise price per share equal to $15.675. The Series&#160;D Warrants may be exercised at any time after Shareholder Approval for a period of two and one-half&#160;years. Under an alternative cashless exchange provision in the Series&#160;D Warrants, holders thereof have the right to receive an aggregate number of shares equal to the product of (i)&#160;the aggregate number of common shares that would be issuable upon a cash exercise of the Series&#160;D Warrants and (ii)&#160;3.0. In addition, on the 11th trading day following each of (i)&#160;the later of (A)&#160;the Stockholder Approval Date and (B)&#160;the Effective Date (as that term is defined in the SPA) and (ii)&#160;each subsequent date that a Registration Statement (as that term is defined in the SPA) is declared effective by the Securities and Exchange Commission, if any (each such trading day, a &#8220;Reset Date&#8221;). The exercise price and number of shares of common stock issuable upon exercise of the Series&#160;D Warrants is subject to appropriate adjustment in the event of (i)&#160;stock dividends, stock splits, stock combinations, reclassifications, reorganizations or similar events, or (ii)&#160;upon any distributions of assets, including cash, stock or other property to our stockholders. In addition, on the 11th trading day following each of (i)&#160;the later of (A)&#160;the Stockholder Approval Date and (B)&#160;the Effective Date and (ii)&#160;each subsequent date that a Registration Statement is declared effective by the Securities and Exchange Commission, if any, the Series&#160;D Warrants contain a reset of the exercise price to a price equal to the lesser of (i)&#160;the then applicable exercise price and (ii)&#160;the greater of the Floor Price and the lowest volume weighted average price for the ten trading days immediately preceding the Reset Date. Upon such reset of the exercise price, the number of shares issuable under the Series&#160;D Warrants shall be increased such that the aggregate exercise price of the Series&#160;D Warrants shall remain unchanged following such reset. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="font-style:italic;letter-spacing:0.2pt;">Exercise Limitation.&nbsp;&nbsp;&nbsp;</font><font style="letter-spacing:0.2pt;">A holder will not have the right to exercise any portion of the Series&#160;D Warrants if the holder (together with its affiliates and certain related parties) would beneficially own in excess of 4.99% of the number of shares of our Common Stock outstanding immediately after giving effect to that proposed exercise, as such&#160;percentage ownership is determined in accordance with the terms of the Series&#160;D Warrants. However, any holder may increase or decrease such&#160;percentage to any other&#160;percentage not in excess of 9.99%, provided that any increase in such&#160;percentage shall not be effective until 61&#160;days following notice from the holder to us. </font>
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          <font style="font-style:italic;letter-spacing:0.2pt;">Transferability.&nbsp;&nbsp;&nbsp;</font><font style="letter-spacing:0.2pt;">Subject to applicable laws, the Series&#160;D Warrants may be offered for sale, sold, transferred or assigned without our consent. </font>
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          <font style="font-style:italic;letter-spacing:0.2pt;">Exchange Listing.&nbsp;&nbsp;&nbsp;</font><font style="letter-spacing:0.2pt;">We do not intend to list the Series&#160;D Warrants on any securities exchange or nationally recognized trading system. </font>
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          <font style="font-style:italic;letter-spacing:0.2pt;">Fundamental Transactions.&nbsp;&nbsp;&nbsp;</font><font style="letter-spacing:0.2pt;">In the event of a fundamental transaction, as described in the Series&#160;D Warrants and generally including any reorganization, recapitalization or reclassification of our Common Stock, the sale, transfer or other disposition of all or substantially all of our properties or assets, our consolidation or merger with or into another person, the acquisition of more than 50% of our outstanding Common Stock, or any person or group becoming the beneficial owner of 50% or more of the voting power represented by our outstanding Common Stock, the holders of the Series&#160;D Warrants will be entitled to receive upon exercise of the Series&#160;D Warrants the kind and amount of securities, cash or other property that the holders would have received had they exercised the Series&#160;D Warrants immediately prior to such fundamental transaction. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="font-style:italic;letter-spacing:0.2pt;">Rights as a Stockholder.&nbsp;&nbsp;&nbsp;</font><font style="letter-spacing:0.2pt;">Except as otherwise provided in the Series&#160;D Warrants or by virtue of such holder&#8217;s ownership of shares of our Common Stock, the holder of a Series&#160;D Warrant does not have the </font>
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          <font style="letter-spacing:0.2pt;">27</font>&#8203;</div>
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        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a>
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          <font style="letter-spacing:0.24pt;">Description of Securities Being Registered</font>
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          <font style="letter-spacing:0.2pt;">rights or privileges of a holder of our Common Stock, including any voting rights, until the holder exercises the Series&#160;D Warrant. </font>
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          <font style="font-style:italic;letter-spacing:0.2pt;">Registration Rights.&nbsp;&nbsp;&nbsp;</font><font style="letter-spacing:0.2pt;">Pursuant to the PIPE SPA, we agreed to (i)&#160;prepare and file with the SEC the registration statement of which this prospectus forms a part to permit the resale of the Resale Shares and (ii)&#160;subject to certain exceptions, to use reasonable best efforts to keep such registration statement effective under the Securities Act until (x)&#160;all Resale Shares the offer and resale of which is registered by the registration statement have been sold, transferred or otherwise disposed of by the Selling Stockholders, (y)&#160;the Resale Shares are sold, transferred or otherwise disposed of pursuant to Rule&#160;144 of the Securities Act, or (z)&#160;the Resale Shares have become eligible for sale by the Selling Stockholders pursuant to Rule&#160;144 without any restriction on the volume or manner of such sale and all restrictive legends and stop transfer instructions have been removed with respect to all book entries representing the Resale Shares. </font>
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          <font style="letter-spacing:0.2pt;">Governing Law.&nbsp;&nbsp;&nbsp;</font><font style="font-style:normal;letter-spacing:0.2pt;">The Series&#160;D Warrants are governed by New York law. </font>
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          <font style="letter-spacing:0.2pt;">28</font>
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        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a><a name="tCUFI">&#8203;</a>
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        <div style="text-align:center; width:456pt; line-height:20pt;font-weight:bold;font-size:18pt;">
          <font style="letter-spacing:-0.36pt;">Certain U.S. Federal Income Tax Considerations</font><font style="font-weight:normal;letter-spacing:0.36pt;"> </font>
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          <font style="letter-spacing:0.2pt;">The following discussion summarizes certain U.S. federal income tax considerations of the acquisition, ownership and disposition of the Common Stock offered by this prospectus but does not purport to be a complete analysis of all potential tax effects. This discussion does not address effects of other U.S. federal tax laws, such as estate and gift tax laws, or of state, local, non-U.S. or other tax considerations that may be relevant to a purchaser or holder of the Common Stock in light of their particular circumstances. This discussion is based on the U.S. Internal Revenue Code of 1986, as amended (the &#8220;Code&#8221;), the Treasury regulations promulgated thereunder, judicial decisions, and published rulings and administrative pronouncements of the U.S. Internal Revenue Service (the &#8220;IRS&#8221;), in each case as of the date hereof. These authorities may change, possibly with retroactive effect, or may be subject to differing interpretations that may adversely affect a holder of the Common Stock. There can be no assurance the IRS or a court will not take a contrary position to that discussed below regarding the acquisition, ownership and disposition of the Common Stock. </font>
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          <font style="letter-spacing:0.2pt;">This discussion is limited to holders that hold the Common Stock as a capital asset within the meaning of Section&#160;1221 of the Code (generally property held for investment). This discussion does not describe all of the U.S. federal income tax consequences that may be relevant to a holder in light of its particular circumstances, including the impact of the alternative minimum tax and of the Medicare contribution tax on net investment income. In addition, it does not address consequences for holders subject to special rules, including without limitation: </font>
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          <font style="letter-spacing:0.2pt;">U.S. expatriates and former citizens or long-term residents of the United States; </font>
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          <font style="letter-spacing:0.2pt;">persons holding the Common Stock as part of a hedge, straddle, conversion, or other integrated transaction; </font>
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          <font style="letter-spacing:0.2pt;">banks, insurance companies, and other financial institutions; </font>
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          <font style="letter-spacing:0.2pt;">brokers, dealers or traders in securities; </font>
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          <font style="letter-spacing:0.2pt;">&#8220;controlled foreign corporations,&#8221; &#8220;passive foreign investment companies,&#8221; and corporations that accumulate earnings </font>
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          <font style="letter-spacing:0.2pt;">to avoid U.S. federal income tax; </font>
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          <font style="letter-spacing:0.2pt;">S corporations or entities or arrangements that are treated as partnerships for U.S. federal income tax purposes (and investors therein); </font>
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          <font style="letter-spacing:0.2pt;">tax-exempt organizations or governmental organizations; </font>
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          <font style="letter-spacing:0.2pt;">U.S. persons whose functional currency is not the U.S. dollar; </font>
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          <font style="letter-spacing:0.2pt;">persons subject to special tax accounting rules; </font>
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          <font style="letter-spacing:0.2pt;">persons who hold or receive the Common Stock pursuant to the exercise of any employee stock option or otherwise as compensation; </font>
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          <font style="letter-spacing:0.2pt;">persons deemed to sell our Common Stock under the constructive sale provisions of the Code; </font>
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          <font style="letter-spacing:0.2pt;">tax-qualified retirement plans, individual retirement accounts or other tax-deferred accounts; and </font>
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          <font style="letter-spacing:0.2pt;">&#8220;qualified foreign pension funds&#8221; as defined in Section&#160;897(l)(2) of the Code. </font>
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          <font style="letter-spacing:0.2pt;">If a partnership (or any other entity treated as a partnership for U.S. federal income tax purposes) holds the Common Stock, the U.S. federal income tax treatment of a partner of that partnership generally will depend upon the status of the partner and the activities of the partnership. If you are a partnership or a partner of a partnership holding the Common Stock, you should consult your tax advisors as to the particular U.S. federal income tax consequences of holding and disposing of the Common Stock. </font>
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          <font style="letter-spacing:-0.2pt;">This discussion is for information purposes only and is not tax advice. You should consult your own independent tax advisor concerning the application of the U.S. federal income tax laws to your particular circumstances as </font>
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          <font style="letter-spacing:0.2pt;">29</font>&#8203;</div>
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        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a>
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        <div style="margin-top:6pt; width:456pt; line-height:14pt;font-size:12pt;">
          <font style="letter-spacing:0.24pt;">Certain U.S. Federal Income Tax Considerations</font>
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          <font style="letter-spacing:-0.2pt;">well as any tax consequences for the acquisition, ownership, or disposition of the Common Stock arising under other U.S. federal tax laws and the laws of any state, local or non-U.S. tax jurisdiction or under any applicable income tax treaty.</font><font style="font-weight:normal;letter-spacing:0.2pt;"> </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">For purposes of this discussion, a &#8220;U.S. holder&#8221; is a beneficial owner of our Common Stock that, for U.S. federal income tax purposes, is or is treated as: </font>
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          <font style="letter-spacing:0.2pt;">an individual who is a citizen or resident of the United States; </font>
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          <font style="letter-spacing:0.2pt;">a corporation created or organized under the laws of the United States, any state thereof, or the District of Columbia; </font>
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          <font style="letter-spacing:0.2pt;">an estate the income of which is subject to U.S. federal income taxation regardless of its source; or </font>
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          <font style="font-family:Times New Roman, Times, serif;">&#10146;</font>
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        <div style=" margin-top:6.09pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:40pt;">
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          <font style="letter-spacing:0.2pt;">a trust that (i)&#160;is subject to the primary supervision of a U.S. court and the control of one or more &#8220;United States persons&#8221; &#8203;(within the meaning of Section&#160;770 1(a)(30) of the Code) or (ii)&#160;has a valid election in effect to be treated as a United States person for U.S. federal income tax purposes. </font>
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          <font style="letter-spacing:0.2pt;">A &#8220;non-U.S. holder&#8221; is any beneficial owner of our Common Stock that is not a U.S. holder. </font>
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          <font style="letter-spacing:-0.24pt;">U.S. Holders</font><font style="font-weight:normal;letter-spacing:0.24pt;"> </font>
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        <div style="margin-left:20pt; margin-top:12pt; width:436pt; line-height:12pt;font-style:italic;font-weight:bold;">
          <font style="letter-spacing:-0.2pt;">Distributions in General</font><font style="font-style:normal;font-weight:normal;letter-spacing:0.2pt;"> </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">If distributions are made with respect to the Common Stock, such distributions will be treated as dividends to the extent of our current or accumulated earnings and profits as determined under the Code. Subject to customary conditions and limitations, dividends will be eligible for the dividends-received deduction in the case of U.S. holders that are (or are treated for U.S. federal income tax purposes) as corporations. Dividends paid to non-corporate U.S. holders generally will qualify for taxation at preferential rates if those holders meet certain holding period and other applicable requirements. Dividends received by non-corporate U.S. holders may also be subject to the additional 3.8% tax on net investment income. Any portion of a distribution that exceeds our current and accumulated earnings and profits will first be applied to reduce a U.S. holder&#8217;s tax basis in the Common Stock, but not below zero. Distributions in excess of our current and accumulated earnings and profits and in excess of a U.S. holder&#8217;s tax basis in its shares will be taxable as gain from the disposition of the Common Stock, the tax treatment of which is discussed below. </font>
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          <font style="letter-spacing:-0.2pt;">Extraordinary Dividends</font><font style="font-style:normal;font-weight:normal;letter-spacing:0.2pt;"> </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">Dividends that exceed certain thresholds in relation to a U.S. holder&#8217;s tax basis in the Common Stock could be characterized as &#8220;extraordinary dividends&#8221; under Section&#160;1059 of the Code. Corporate U.S. holders that have held our Common Stock for two&#160;years or less before the dividend announcement date and that receive an extraordinary dividend will generally be required to reduce their tax basis in the stock by the nontaxed portion of the dividend due to the dividends-received deduction. If the amount of reduction exceeds the U.S. holder&#8217;s tax basis in the stock, the excess will be taxable as gain from the disposition of the stock, the tax treatment of which is discussed below. Non-corporate U.S. holders that receive an extraordinary dividend will be required to treat any losses on the sale of our Common Stock as long-term capital losses to the extent of the extraordinary dividends such U.S. holders receive that qualify for taxation as the preferential rates discussed above under &#8220;&#8212; Distributions in General.&#8221; U.S. holders are urged to consult their tax advisors with respect to the eligibility for and amount of any dividend received deduction and the application of Section&#160;1059 of the Code to any dividends they receive. </font>
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        <div style="margin-left:20pt; margin-top:12pt; width:436pt; line-height:12pt;font-style:italic;font-weight:bold;">
          <font style="letter-spacing:-0.2pt;">Disposition of Common Stock by Sale, Exchange or Redemption</font><font style="font-style:normal;font-weight:normal;letter-spacing:0.2pt;"> </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">Upon any sale or disposition (other than certain redemptions, as discussed below) of the Common Stock, a U.S. holder generally will recognize capital gain or loss equal to the difference between the amount realized by the U.S. holder and the U.S. holder&#8217;s adjusted tax basis in the Common Stock. Such capital gain or loss will be long-term capital gain or loss if the U.S. holder&#8217;s holding period for the Common Stock is longer than </font>
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          <font style="letter-spacing:0.2pt;">&#160;</font>
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          <font style="letter-spacing:0.2pt;">30</font>
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        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a>
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      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:6pt; width:456pt; line-height:14pt;font-size:12pt;">
          <font style="letter-spacing:0.24pt;">Certain U.S. Federal Income Tax Considerations</font>
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        <div style="margin-top:5.833pt; width:456pt;">
          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
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          <font style="letter-spacing:0.2pt;">one year. Non-corporate U.S. holders may be eligible for preferential tax rates on long-term capital gains but also may be subject to the additional 3.8% tax on net investment income. The deductibility of capital losses is subject to limitations. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:0.2pt;">A redemption of the Common Stock will be treated as a sale or exchange described in the preceding paragraph if the redemption, based on the facts and circumstances, is treated for U.S. federal income tax purposes as (i)&#160;a &#8220;complete termination&#8221; of your interest in the Common Stock, (ii)&#160;a &#8220;substantially disproportionate&#8221; redemption of your Common Stock, or (iii)&#160;is &#8220;not essentially equivalent to a dividend&#8221;, each within the meaning of Section&#160;302 of the Code. In determining whether any of these tests has been met, you must take into account not only the Common Stock and other equity interests that you actually own but also other equity interests that you constructively own under U.S. federal income tax rules. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:0.2pt;">If you meet none of the alternative tests described above, the redemption will be treated as a distribution subject to the rules described under &#8220;&#8212; Distributions In General.&#8221; If a redemption of the Common Stock is treated as a distribution that is taxable as a dividend, you are urged to consult your tax advisor regarding the allocation of your tax basis as between the redeemed and remaining shares of Common Stock. </font>
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        <div style="margin-left:20pt; margin-top:12pt; width:436pt; line-height:12pt;font-style:italic;font-weight:bold;">
          <font style="letter-spacing:-0.2pt;">Information Reporting and Backup Withholding</font><font style="font-style:normal;font-weight:normal;letter-spacing:0.2pt;"> </font>
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        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:0.2pt;">We or an applicable withholding agent will report to our U.S. holders and the IRS the amount of dividends (including deemed dividends) paid during each year and the amount of any tax withheld with respect to the Common Stock. Certain non-corporate U.S. holders may be subject to U.S. backup withholding at a rate of 28% on payments of dividends on the Common Stock unless the holder furnishes the payor or its agent with a taxpayer identification number, certified under penalties of perjury, and certain other information or otherwise establishes an exemption from backup withholding. Backup withholding tax is not an additional tax. Any amounts withheld under the backup withholding rules may be allowed as a refund or a credit against a U.S. holder&#8217;s U.S. federal income tax liability, provided the U.S. holder timely furnishes the required information to the IRS. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:14pt;font-weight:bold;font-size:12pt;">
          <font style="letter-spacing:-0.24pt;">Non-U.S. Holders</font><font style="font-weight:normal;letter-spacing:0.24pt;"> </font>
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        <div style="margin-left:20pt; margin-top:12pt; width:436pt; line-height:12pt;font-style:italic;font-weight:bold;">
          <font style="letter-spacing:-0.2pt;">Distributions</font><font style="font-style:normal;font-weight:normal;letter-spacing:0.2pt;"> </font>
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        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:0.2pt;">If distributions are made with respect to the Common Stock, such distributions will be treated as dividends to the extent of our current or accumulated earnings and profits as determined under the Code and may be subject to withholding as discussed below. Any portion of a distribution that exceeds our current and accumulated earnings and profits will first be applied to reduce the Non-U.S. holder&#8217;s basis in the Common Stock, but not below zero. If the distribution exceeds our current and accumulated earnings and profits and the Non-U.S. holder&#8217;s basis, the excess will be treated as gain from the disposition of the Common Stock, the tax treatment of which is discussed below. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:0.2pt;">In addition, if we are classified as a U.S. real property holding corporation (a &#8220;USRPHC&#8221;) within the meaning of Section&#160;897(c) of the Code and any distribution exceeds our current and accumulated earnings and profits, we will need to satisfy our withholding requirements either by (a)&#160;treating the entire distribution (even if in excess of earnings and profits) as a dividend subject to the withholding rules described below and withhold at a minimum rate of 15% or such lower rate as may be specified by an applicable income tax treaty for distributions from a USRPHC; or (b)&#160;treating (i)&#160;only the amount of the distribution equal to our reasonable estimate of our current and accumulated earnings and profits as a dividend subject to the withholding rules in the following paragraph; and (ii)&#160;the excess portion of the distribution as subject to withholding at a rate of 15% (or such lower rate as may be specified by an applicable income tax treaty), as if such excess were the result of a sale of shares in a USRPHC, with a credit generally allowed against the Non-U.S. holder&#8217;s U.S. federal income tax liability for the tax withheld from such excess. We believe that we currently are not a USRPHC, and we do not expect to become a USRPHC for the foreseeable future (see discussion of USRPHCs below under &#8220;&#8212; </font><font style="font-style:italic;letter-spacing:0.2pt;">Disposition of Common Stock, Including Redemptions</font><font style="letter-spacing:0.2pt;">&#8221;). </font>
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          <font style="letter-spacing:0.2pt;">Dividends (including amounts distributed by a USRPHC and subject to withholding as dividends per the preceding paragraph) paid to a Non-U.S. holder of the Common Stock will be subject to withholding of U.S. </font>
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          <font style="letter-spacing:0.2pt;">&#160;</font>
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          <font style="letter-spacing:0.2pt;">31</font>&#8203;</div>
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      <div style="padding:0pt;margin:0pt;font-family:calibri, arial, sans-serif;font-weight:normal;font-style:normal;font-size:8pt;line-height:8pt;">
        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a>
      </div>
      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:6pt; width:456pt; line-height:14pt;font-size:12pt;">
          <font style="letter-spacing:0.24pt;">Certain U.S. Federal Income Tax Considerations</font>
        </div>
        <div style="margin-top:5.833pt; width:456pt;">
          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
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          <font style="letter-spacing:0.2pt;">federal income tax at a 30% rate or such lower rate as may be specified by an applicable income tax treaty. However, dividends that are treated as being effectively connected with the conduct of a trade or business by the Non-U.S. holder within the United States (and, where a tax treaty applies, are attributable to a permanent establishment maintained by the Non-U.S. holder in the United States) are not subject to this withholding tax, provided that certain certification and disclosure requirements are satisfied including completing IRS Form W-8ECI (or other applicable form). Instead, such dividends are subject to U.S. federal income tax on a net income basis in the same manner as if the Non-U.S. holder were a United States person (as defined under the Code), unless an applicable income tax treaty provides otherwise. Any such effectively connected dividends received by a foreign corporation may be subject to an additional &#8220;branch profits tax&#8221; at a 30% rate or such lower rate as may be specified by an applicable income tax treaty. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">A Non-U.S. holder of the Common Stock who wishes to claim the benefit of an applicable treaty rate and avoid backup withholding for dividends, as discussed below, will be required to (i)&#160;complete IRS Form&#160;W-8BEN or Form W-8BEN-E (or other applicable form) and certify under penalty of perjury that such holder is not a United States person as defined under the Code and is eligible for treaty benefits, or (ii)&#160;if the Common Stock is held through certain foreign intermediaries, satisfy the relevant certification requirements of applicable Treasury regulations. A Non-U.S. holder of the Common Stock eligible for a reduced rate of U.S. withholding tax pursuant to an income tax treaty may obtain a refund of any excess amounts withheld by timely filing an appropriate claim for refund with the U.S. Internal Revenue Service. </font>
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        <div style="margin-left:20pt; margin-top:12pt; width:436pt; line-height:12pt;font-style:italic;font-weight:bold;">
          <font style="letter-spacing:-0.2pt;">Disposition of Common Stock, Including Redemptions</font><font style="font-style:normal;font-weight:normal;letter-spacing:0.2pt;"> </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">Any gain realized by a Non-U.S. holder on the disposition of the Common Stock generally will not be subject to U.S. federal income or withholding tax unless: </font>
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          <font style="font-family:Times New Roman, Times, serif;">&#10146;</font>
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        <div style=" margin-top:6pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:40pt;">
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          <font style="letter-spacing:0.2pt;">the gain is effectively connected with the conduct of a trade or business by the Non-U.S. holder in the United States (and, if required by an applicable income tax treaty, attributable to a permanent establishment maintained by the Non-U.S. holder in the United States); </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
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          <font style="font-family:Times New Roman, Times, serif;">&#10146;</font>
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          <font style="letter-spacing:0.2pt;">the Non-U.S. holder is an individual who is present in the United States for 183&#160;days or more in the taxable year of disposition, and certain other conditions are met; or </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
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          <font style="letter-spacing:0.2pt;">we are or have been a USRPHC, as defined in Section&#160;897(c) of the Code, and a Non-U.S. holder owned directly or pursuant to applicable attribution rules at any time during the five-year period ending on the date of disposition more than 5% of the Common Stock&#8201;&#8212;&#8201;assuming that the Common Stock is regularly traded on an established securities market, within the meaning of Section&#160;897(c)(3) of the Code. </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">A Non-U.S. holder described in the first bullet point immediately above will generally be subject to tax on the gain derived from the sale under regular graduated U.S. federal income tax rates in the same manner as if the Non-U.S. holder were a United States person as defined under the Code, and, if it is a corporation, may also be subject to branch profits tax equal of 30% (generally applicable to its effectively connected earnings and profits) or at such lower rate as may be specified by an applicable income tax treaty. </font>
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          <font style="letter-spacing:0.2pt;">An individual Non-U.S. holder described in the second bullet point immediately above will be subject to a flat 30% tax (or at such reduced rate as may be provided by an applicable tax treaty) on the gain derived from the sale, which may be offset by U.S. source capital losses, even if the individual is not considered a resident of the United States for U.S. federal income tax purposes. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">A Non-U.S. holder described in the third bullet point above will be subject to U.S. federal income tax under regular graduated U.S. federal income tax rates with respect to the gain realized in the same manner as if the Non-U.S. holder were a United States person as defined under the Code. A corporation is a USRPHC if it is a U.S. corporation and the fair market value of its U.S. real property interests equals or exceeds 50% of the sum of the fair market value of its worldwide real property interests and its other assets used or held for use in a trade or business. We believe that we currently are not a USRPHC for U.S. federal income tax purposes, and we do not expect to become a USRPHC for the foreseeable future. Our Common Stock will be listed on the NASDAQ Capital Market and we believe that, for as long as we continue to be so listed, our </font>
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          <font style="letter-spacing:0.2pt;">32</font>
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        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a>
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        <div style="margin-top:6pt; width:456pt; line-height:14pt;font-size:12pt;">
          <font style="letter-spacing:0.24pt;">Certain U.S. Federal Income Tax Considerations</font>
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          <font style="letter-spacing:0.2pt;">Common Stock will be treated as regularly traded on an established securities market. However, if we become a USRPHC and our Common Stock is regularly traded on an established securities market, a Non-U.S. holder generally will be subject to U.S. federal income tax on any gain from the disposition of such stock if such Non-U.S. holder has owned or is deemed to have owned more than 5% of our Common Stock, at any time within the shorter of the five-year period preceding the disposition or such holder&#8217;s holding period for such stock. </font>
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          <font style="letter-spacing:0.2pt;">If a Non-U.S. holder is subject to U.S. federal income tax on any sale, exchange, redemption (except as discussed below), or other disposition of the Common Stock, the Non-U.S. holder will recognize capital gain or loss equal to the difference between the amount realized by the Non-U.S. holder and the Non-U.S. holder&#8217;s adjusted tax basis in the Common Stock. Such capital gain or loss will be long-term capital gain or loss if the Non-U.S. holder&#8217;s holding period for the Common Stock is longer than one year. A Non-U.S. holder should consult its own independent tax advisors with respect to applicable tax rates and netting rules for capital gains and losses. Certain limitations exist on the deduction of capital losses by both corporate and non-corporate taxpayers. </font>
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          <font style="letter-spacing:0.2pt;">If a Non-U.S. holder is subject to U.S. federal income tax on any disposition of the Common Stock, a redemption of shares of the Common Stock will be a taxable event. If the redemption is treated as a sale or exchange, instead of as a dividend, a Non-U.S. holder generally will recognize capital gain or loss, equal to the difference between the amount of cash received and fair market value of any property received and the Non-U.S. holder&#8217;s adjusted tax basis in the Common Stock redeemed (except that to the extent that any cash received is attributable to any accrued but unpaid dividends), and such capital gain or loss will be long-term capital gain or loss if the Non-U.S. holder&#8217;s holding period for such Common Stock exceeds one year,. A payment made in redemption of the Common Stock may be treated as a dividend (subject to taxation as discussed above under &#8220;&#8212; </font><font style="font-style:italic;letter-spacing:0.2pt;">Disposition of Common Stock, Including Redemptions</font><font style="letter-spacing:0.2pt;">&#8221;), rather than as payment in exchange for the Common Stock, in the same circumstances discussed above under &#8220;&#8212;&#160;</font><font style="font-style:italic;letter-spacing:0.2pt;">Disposition of Common Stock, Including Redemptions</font><font style="letter-spacing:0.2pt;">.&#8221; Each Non-U.S. holder of the Common Stock should consult its own independent tax advisors to determine whether a payment made in redemption of the Common Stock will be treated as a dividend or as payment in exchange for the Common Stock. </font>
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        <div style="margin-left:20pt; margin-top:12pt; width:436pt; line-height:12pt;font-style:italic;font-weight:bold;">
          <font style="letter-spacing:-0.2pt;">Information Reporting and Backup Withholding</font><font style="font-style:normal;font-weight:normal;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:0.2pt;">We must annually report to the IRS and to each Non-U.S. holder the amount of dividends (including constructive dividends) paid to such Non-U.S. holder and the tax withheld with respect to such dividends, regardless of whether withholding was required. Copies of the information returns reporting such dividends and withholding may also be made available under the provisions of an applicable tax treaty or agreement with the tax authorities in the country in which the non-U.S. holder resides. U.S. backup withholding will generally apply to the payment of dividends to non-U.S. holders unless such non-U.S. holders furnish to the payor an IRS Form W-8BEN or Form W-8BEN-E (or other applicable form) or otherwise establish an exemption. </font>
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          <font style="letter-spacing:0.2pt;">Payment by a U.S. office of a broker of the proceeds of a sale of shares of our Common Stock is subject to both backup withholding and information reporting unless the non-U.S. holder, or beneficial owner thereof, as applicable, certifies that it is a non-U.S. holder on Form W-8BEN or Form W-8BEN-E (or other suitable substitute or successor form), or otherwise establishes an exemption. Subject to certain exceptions, backup withholding and information reporting generally will not apply to a payment of proceeds from the sale of shares of our Common Stock if such sale is effected through a foreign office of a broker, provided that the broker does not have certain U.S. connections. Any amount withheld under the backup withholding rules from a payment to a non-U.S. holder is allowable as a credit against such holder&#8217;s U.S. federal income tax liability (if any), which may entitle the holder to a refund if in excess of such liability, provided that the holder timely provides the required information to the IRS. Non-U.S. holders are urged to consult their own tax advisers regarding the application of backup withholding in their particular circumstances and the availability of and procedure for obtaining an exemption from backup withholding under current Treasury Regulations. </font>
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        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a>
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        <div style="margin-top:6pt; width:456pt; line-height:14pt;font-size:12pt;">
          <font style="letter-spacing:0.24pt;">Certain U.S. Federal Income Tax Considerations</font>
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          <font style="letter-spacing:-0.2pt;">Foreign Account Tax Compliance Act</font><font style="font-style:normal;font-weight:normal;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:0.2pt;">Sections&#160;1471 to 1474 of the Code (such sections, and the Treasury Regulations and administrative guidance issued thereunder, commonly referred to as FATCA) impose a 30% U.S. withholding tax on certain &#8220;withholdable payments&#8221; made to a &#8220;foreign financial institution&#8221; or a &#8220;nonfinancial foreign entity.&#8221; &#8220;Withholdable payments&#8221; include payments of dividends and the gross proceeds from a disposition of certain property (such as shares of our Common Stock), if such disposition occurs after December&#160;31, 2018. In general, if a holder is a &#8220;foreign financial institution&#8221; &#8203;(which includes investment entities such as hedge funds and private equity funds), the 30% withholding tax will apply to withholdable payments made to such holder, unless such holder enters into an agreement with the U.S. Department of Treasury to collect and provide substantial information regarding its U.S. account holders, including certain account holders that are foreign entities with U.S. owners, and to withhold 30% on certain &#8220;pass-through payments.&#8221; If such holder is a &#8220;non-financial foreign entity,&#8221; FATCA also generally will impose a withholding tax of 30% on withholdable payments made to such holder unless the holder provides the withholding agent with a certification that it does not have any &#8220;substantial United States owners&#8221; or a certification identifying its direct and indirect substantial United States owners. Intergovernmental agreements between the United States and a holder&#8217;s resident country may modify some of the foregoing requirements. </font>
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          <font style="letter-spacing:0.2pt;">Although withholding under FATCA would also have applied to payments of gross proceeds from the sale or other disposition of the Common Stock on or after January&#160;1, 2019, Treasury Regulations proposed in late 2018 eliminate FATCA withholding on payments of gross proceeds entirely. Taxpayers generally may rely on these proposed Treasury Regulations until final Treasury Regulations are issued. </font>
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          <font style="letter-spacing:0.2pt;">We will not pay any additional amounts to holders of the Common Stock in respect of any amounts withheld. Non-U.S. holders should consult their own tax advisers with respect to the U.S. federal income tax consequences of FATCA on their ownership and disposition of shares of our Common Stock. </font>
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          <font style="letter-spacing:0.2pt;">Documentation that holders provide in order to be treated as FATCA compliant may be reported to the IRS and other tax authorities, including information about a holder&#8217;s identity, its FATCA status and if applicable, its direct and indirect U.S. owners. Prospective investors should consult their tax advisers about how information reporting and the possible imposition of withholding tax under FATCA may apply to their investment in the Common Stock.</font>
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          <font style="letter-spacing:-0.36pt;">P</font><font style="text-transform:lowercase;letter-spacing:-0.36pt;">LAN OF</font><font style="letter-spacing:-0.36pt;"> D</font><font style="text-transform:lowercase;letter-spacing:-0.36pt;">ISTRIBUTION</font><font style="font-weight:normal;letter-spacing:0.36pt;"> </font>
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          <font style="letter-spacing:0.2pt;">The Selling Stockholders, which as used herein includes donees, pledgees, transferees or other successors-in-interest selling Resale Shares or interests in Resale Shares received after the date of this prospectus from a Selling Stockholder as a gift, pledge, partnership distribution or other transfer, may, from time to time, sell, transfer or otherwise dispose of any or all of their Resale Shares or interests in Resale Shares on any stock exchange, market or trading facility on which the shares are traded or in private transactions. These dispositions may be at fixed prices, at prevailing market prices at the time of sale, at prices related to the prevailing market price, at varying prices determined at the time of sale, or at negotiated prices. </font>
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          <font style="letter-spacing:0.2pt;">The Selling Stockholders may use any one or more of the following methods when disposing of shares or interests therein: </font>
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          <font style="letter-spacing:0.2pt;">ordinary brokerage transactions and transactions in which the broker-dealer solicits purchasers; </font>
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          <font style="letter-spacing:0.2pt;">block trades in which the broker-dealer will attempt to sell the shares as agent, but may position and resell a portion of the block as principal to facilitate the transaction; </font>
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          <font style="letter-spacing:0.2pt;">purchases by a broker-dealer as principal and resale by the broker-dealer for its account; </font>
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          <font style="letter-spacing:0.2pt;">an exchange distribution in accordance with the rules of the applicable exchange; </font>
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          <font style="letter-spacing:0.2pt;">privately negotiated transactions; </font>
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          <font style="letter-spacing:0.2pt;">short sales effected after the date the registration statement of which this prospectus is a part is declared effective by the SEC; </font>
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          <font style="letter-spacing:0.2pt;">through the writing or settlement of options or other hedging transactions, whether through an options exchange or otherwise; </font>
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          <font style="letter-spacing:0.2pt;">broker-dealers may agree with the Selling Stockholders to sell a specified number of such shares at a stipulated price per share; </font>
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          <font style="letter-spacing:0.2pt;">a combination of any such methods of sale; and </font>
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          <font style="letter-spacing:0.2pt;">any other method permitted by applicable law. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:0.2pt;">The Selling Stockholders may, from time to time, pledge or grant a security interest in some or all of the Resale Shares owned by them and, if they default in the performance of their secured obligations, the pledgees or secured parties may offer and sell the Resale Shares, from time to time, under this prospectus, or under an amendment to this prospectus under Rule&#160;424(b)(3) or other applicable provision of the Securities Act amending the list of Selling Stockholders to include the pledgee, transferee or other successor in interest as Selling Stockholders under this prospectus. The Selling Stockholders also may transfer the Resale Shares in other circumstances, in which case the transferees, pledgees or other successors in interest will be the selling beneficial owners for purposes of this prospectus. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">In connection with the sale of shares of our Common Stock or interests therein under this prospectus, the Selling Stockholders may enter into hedging transactions with broker-dealers or other financial institutions, which may in turn engage in short sales of shares of our Common Stock in the course of hedging the positions they assume. The Selling Stockholders may also sell shares of our Common Stock short and deliver these securities to close out their short positions, or loan or pledge the shares to broker-dealers that in turn may sell these securities. The Selling Stockholders may also enter into option or other transactions with broker-dealers or other financial institutions or the creation of one or more derivative securities which require the delivery to such broker-dealer or other financial institution of shares offered by this prospectus, which shares such broker-dealer or other financial institution may resell pursuant to this prospectus (as supplemented or amended to reflect such transaction). </font>
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          <font style="letter-spacing:0.2pt;">The aggregate proceeds to the Selling Stockholders from the sale of the Resale Shares offered by them will be the purchase price of the Resale Shares less discounts or commissions, if any. Each of the Selling Stockholders reserves the right to accept and, together with their agents from time to time, to reject, in </font>
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          <font style="letter-spacing:0.24pt;">P</font><font style="text-transform:lowercase;letter-spacing:0.24pt;">LAN OF</font><font style="letter-spacing:0.24pt;"> D</font><font style="text-transform:lowercase;letter-spacing:0.24pt;">ISTRIBUTION</font>
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          <font style="letter-spacing:0.2pt;">whole or in part, any proposed purchase of Resale Shares to be made directly or through agents. We will not receive any of the proceeds from sales of Resale Shares effected by the Selling Stockholders. </font>
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          <font style="letter-spacing:0.2pt;">The Selling Stockholders also may resell all or a portion of the shares in open market transactions in reliance upon Rule&#160;144 under the Securities Act of 1933, provided that they meet the criteria and conform to the requirements of that rule. </font>
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          <font style="letter-spacing:0.2pt;">The Selling Stockholders and any underwriters, broker-dealers or agents that participate in the sale of the Resale Shares or interests therein may be &#8220;underwriters&#8221; within the meaning of Section&#160;2(11) of the Securities Act. Any discounts, commissions, concessions or profit they earn on any resale of the Resale Shares may be underwriting discounts and commissions under the Securities Act. Selling Stockholders who are &#8220;underwriters&#8221; within the meaning of Section&#160;2(11) of the Securities Act will be subject to the prospectus delivery requirements of the Securities Act. </font>
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          <font style="letter-spacing:0.2pt;">To the extent required, the shares of our Common Stock to be sold, the names of the Selling Stockholders, the respective purchase prices and offering prices, the names of any agents, broker-dealer or underwriter, any applicable commissions or discounts with respect to a particular offer will be set forth in an accompanying prospectus supplement or, if appropriate, a post-effective amendment to the registration statement that includes this prospectus. </font>
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          <font style="letter-spacing:0.2pt;">In order to comply with the securities laws of some states, if applicable, the Resale Shares may be sold in these jurisdictions only through registered or licensed brokers or dealers. In addition, in some states, the Common Stock may not be sold unless it has been registered or qualified for sale or an exemption from registration or qualification requirements is available and is complied with. </font>
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          <font style="letter-spacing:0.2pt;">We have advised the Selling Stockholders that the anti-manipulation rules of Regulation&#160;M under the Exchange Act may apply to sales of shares in the market and to the activities of the Selling Stockholders and their affiliates. In addition, to the extent applicable, we will make copies of this prospectus (as it may be supplemented or amended from time to time) available to the Selling Stockholders for the purpose of satisfying the prospectus delivery requirements of the Securities Act. The Selling Stockholders may indemnify any broker-dealer that participates in transactions involving the sale of shares against certain liabilities, including liabilities arising under the Securities Act. </font>
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          <font style="letter-spacing:0.2pt;">We have agreed to indemnify the Selling Stockholders against liabilities, including liabilities under the Securities Act and state securities laws, relating to the registration of the shares offered by this prospectus. </font>
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          <font style="letter-spacing:0.2pt;">We have agreed with the Selling Stockholders to keep the registration statement of which this prospectus constitutes a part effective until the earlier of (x)&#160;all Resale Shares the offer and resale of which are registered by the registration statement have been sold, transferred or otherwise disposed of by the Selling Stockholders, (y)&#160;the Resale Shares are sold, transferred or otherwise disposed of pursuant to Rule&#160;144 of the Securities Act, or (z)&#160;the Resale Shares have become eligible for sale by the Selling Stockholders pursuant to Rule&#160;144 without any restriction on the volume or manner of such sale and all restrictive legends and stop transfer instructions have been removed with respect to all book entries representing the Resale Shares. </font>
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        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a><a name="tLEMA">&#8203;</a><a name="tEXP">&#8203;</a><a name="tWYCF">&#8203;</a>
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          <font style="letter-spacing:-0.36pt;">L</font><font style="text-transform:lowercase;letter-spacing:-0.36pt;">EGAL</font><font style="letter-spacing:-0.36pt;"> M</font><font style="text-transform:lowercase;letter-spacing:-0.36pt;">ATTERS</font><font style="font-weight:normal;letter-spacing:0.36pt;"> </font>
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          <font style="letter-spacing:0.2pt;">Certain legal matters will be passed upon for us by Goodwin Procter LLP. Additional legal matters may be passed upon for us or any underwriters, dealers or agents, by counsel that we will name in the applicable prospectus supplement. </font>
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          <font style="letter-spacing:-0.36pt;">E</font><font style="text-transform:lowercase;letter-spacing:-0.36pt;">XPERTS</font><font style="font-weight:normal;letter-spacing:0.36pt;"> </font>
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          <font style="letter-spacing:0.2pt;">Our financial statements as of and for the&#160;years ended December&#160;31, 2023 and 2022, included in this Registration Statement or incorporated herein by reference have been audited by Withum Smith+Brown, PC, independent registered public accounting firm, as stated in their report appearing herein or therein (which report includes an explanatory paragraph about the existence of substantial doubt concerning our ability to continue as a going concern). Such financial statements have been so included in reliance upon the authority of said firm as experts in accounting and auditing. </font>
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          <font style="letter-spacing:-0.36pt;">W</font><font style="text-transform:lowercase;letter-spacing:-0.36pt;">HERE </font><font style="letter-spacing:-0.36pt;">Y</font><font style="text-transform:lowercase;letter-spacing:-0.36pt;">OU</font><font style="letter-spacing:-0.36pt;"> C</font><font style="text-transform:lowercase;letter-spacing:-0.36pt;">AN </font><font style="letter-spacing:-0.36pt;">F</font><font style="text-transform:lowercase;letter-spacing:-0.36pt;">IND</font><font style="letter-spacing:-0.36pt;"> M</font><font style="text-transform:lowercase;letter-spacing:-0.36pt;">ORE</font><font style="letter-spacing:-0.36pt;"> I</font><font style="text-transform:lowercase;letter-spacing:-0.36pt;">NFORMATION</font><font style="font-weight:normal;letter-spacing:0.36pt;"> </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">We have filed with the SEC a registration statement on Form S-1 under the Securities Act with respect to the Common Stock offered hereby. This prospectus does not contain all of the information set forth in the registration statement and the exhibits and schedules thereto. For further information with respect to the Company and its Common Stock, reference is made to the registration statement and the exhibits and any schedules filed therewith. Statements contained in this prospectus as to the contents of any contract or other document referred to are not necessarily complete and, in each instance, if such contract or document is filed as an exhibit, reference is made to the copy of such contract or other document filed as an exhibit to the registration statement, each statement being qualified in all respects by such reference. </font>
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          <font style="letter-spacing:0.2pt;">We are subject to the information reporting requirements of the Exchange Act, and we file periodic reports and other information with the SEC. These filings include our Annual Report on Form 10-K, Quarterly Reports on Form 10-Q, Current Reports on Form 8-K and proxy statements on Schedule&#160;14A, as well as any amendments to those reports and proxy statements, which are available free of charge through our website as soon as reasonably practicable after we file them with, or furnish them to, the SEC. Our Internet website address is www.transcodetherapeutics.com. Our website and the information contained on, or that can be accessed through, the website will not be deemed to be incorporated by reference in, and are not considered part of, this prospectus. You should not rely on any such information in making your decision whether to purchase our securities. The SEC also maintains a website at www.sec.gov that contains reports, proxy and information statements and other information regarding us and other issuers that file electronically with the SEC. </font>
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          <font style="letter-spacing:-0.36pt;">I</font><font style="text-transform:lowercase;letter-spacing:-0.36pt;">NCORPORATION OF</font><font style="letter-spacing:-0.36pt;"> C</font><font style="text-transform:lowercase;letter-spacing:-0.36pt;">ERTAIN</font><font style="letter-spacing:-0.36pt;"> D</font><font style="text-transform:lowercase;letter-spacing:-0.36pt;">OCUMENTS BY</font><font style="letter-spacing:-0.36pt;"> R</font><font style="text-transform:lowercase;letter-spacing:-0.36pt;">EFERENCE</font><font style="font-weight:normal;letter-spacing:0.36pt;"> </font>
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          <font style="letter-spacing:0.2pt;">The SEC allows us to incorporate into this prospectus by reference the information and reports we file with it, which means that we can disclose important information to you by referring you to these documents. The information incorporated by reference is an important part of this prospectus and information that we file after the date hereof with the SEC will automatically update and supersede the information already incorporated by reference. We are incorporating by reference the documents listed below, which we have already filed with the SEC, and any future filings we make with the SEC under Sections&#160;13(a), 13(c), 14 or 15(d) of the Exchange Act, except as to any portion of any future report or document that is not deemed filed under such provisions, after the date of this prospectus and prior to the termination of this offering: </font>
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          <a style="-sec-extract:exhibit" href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1829635/000141057824000413/rnaz-20231231x10k.htm">our Annual Report on Form 10-K for the fiscal year ended December&#160;31, 2023, filed with the SEC on April&#160;1, 2024;</a><font style="letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:0.2pt;">the information included in our <a style="-sec-extract:exhibit" href="https://www.sec.gov/Archives/edgar/data/1829635/000110465924063385/tm2413608-4_defr14a.htm">Definitive Proxy Statement on Schedule&#160;14A, filed with the SEC on May&#160;20, 2024</a>, to the extent incorporated by reference into Part&#160;III of the <a style="-sec-extract:exhibit" href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1829635/000141057824000413/rnaz-20231231x10k.htm">Annual Report on Form 10-K for the fiscal year ended December&#160;31, 2023</a>; </font>
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          <font style="letter-spacing:0.2pt;">our Quarterly Reports on Form 10-Q for the quarter ended March&#160;31, 2024, filed with the SEC on <a style="-sec-extract:exhibit" href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1829635/000155837024008298/rnaz-20240331x10q.htm">May&#160;15, 2024</a>, for the quarter ended June&#160;30, 2024, filed with the SEC on <a style="-sec-extract:exhibit" href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1829635/000155837024012264/rnaz-20240630x10q.htm">August&#160;14, 2024</a>, and for the quarter ended September&#160;30, 2024, filed with the SEC on <a style="-sec-extract:exhibit" href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1829635/000155837024015731/rnaz-20240930x10q.htm">November&#160;14, 2024</a>; </font>
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          <font style="letter-spacing:0.2pt;">our Current Reports on Form 8-K filed with the SEC on <a style="-sec-extract:exhibit" href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1829635/000110465924002225/tm242383d1_8k.htm">January&#160;8, 2024</a>; <a style="-sec-extract:exhibit" href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1829635/000110465924004094/tm243329d1_8k.htm">January&#160;16, 2024</a>; <a style="-sec-extract:exhibit" href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1829635/000110465924005595/tm243790d1_8k.htm">January&#160;22, 2024</a>; <a style="-sec-extract:exhibit" href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1829635/000110465924008839/tm244740d1_8k.htm">January&#160;31, 2024</a>; <a style="-sec-extract:exhibit" href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1829635/000110465924044325/tm2411028d1_8k.htm">April&#160;5, 2024</a>; <a style="-sec-extract:exhibit" href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1829635/000110465924050567/tm2411028d2_8k.htm">April&#160;23, 2024</a>; <a style="-sec-extract:exhibit" href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1829635/000110465924059963/tm2414135d1_8k.htm">May&#160;10, 2024</a>; <a style="-sec-extract:exhibit" href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1829635/000110465924062047/tm2414638d1_8k.htm">May&#160;15, 2024</a>; <a style="-sec-extract:exhibit" href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1829635/000110465924069605/tm2416749d1_8k.htm">June&#160;7, 2024</a>; <a style="-sec-extract:exhibit" href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1829635/000110465924071514/tm2417255d2_8ka.htm">June&#160;14, 2024</a>; <a style="-sec-extract:exhibit" href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1829635/000110465924082155/tm2416389d3_8k.htm">July&#160;24, 2024</a>; <a style="-sec-extract:exhibit" href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1829635/000110465924090559/tm2421945d1_8k.htm">August&#160;16, 2024</a>; <a style="-sec-extract:exhibit" href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1829635/000110465924093614/tm2422872d1_8k.htm">August&#160;28, 2024</a>; <a style="-sec-extract:exhibit" href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1829635/000110465924103706/tm2424982d1_8k.htm">September&#160;27, 2024</a>; <a style="-sec-extract:exhibit" href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1829635/000110465924114773/tm2427567d1_8k.htm">November&#160;6, 2024</a>; <a style="-sec-extract:exhibit" href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1829635/000110465924122379/tm2429410d1_8k.htm">November&#160;25, 2024</a>; <a style="-sec-extract:exhibit" href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1829635/000110465924124097/tm2429720d2_8k.htm">November&#160;29, 2024</a>, and <a style="-sec-extract:exhibit" href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1829635/000110465924124597/tm2429720d1_8k.htm">December&#160;2, 2024</a>; and </font>
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          <font style="letter-spacing:0.2pt;">the description of our common stock contained in <a style="-sec-extract:exhibit" href="https://www.sec.gov/Archives/edgar/data/1829635/000110465921054875/tm2112802d2_8a12b.htm">our registration statement on Form 8-A filed with the SEC on April&#160;26, 2021</a>, as supplemented by the description of our common stock contained in <a style="-sec-extract:exhibit" href="https://www.sec.gov/Archives/edgar/data/1829635/000110465922040778/rnaz-20211231xex4d1.htm">Exhibit&#160;4.1</a> to our Annual Report on Form 10-K for the year ended December&#160;31, 2023, filed with the SEC on April&#160;1, 2024, and any amendment or report filed with the SEC for the purpose of updating such description. </font>
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          <font style="letter-spacing:0.2pt;">Pursuant to Rule&#160;412 under the Securities Act, any statement contained in a document incorporated or deemed to be incorporated by reference into this prospectus will be deemed to be modified or superseded for purposes of this prospectus to the extent that a statement contained in this prospectus or any other subsequently filed document that is deemed to be incorporated by reference into this prospectus modifies or supersedes the statement. Any statement so modified or superseded will not be deemed, except as so modified or superseded, to constitute a part of this prospectus. </font>
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          <font style="letter-spacing:0.2pt;">Upon request, we will provide, without charge, to each person, including any beneficial owner, to whom a copy of this prospectus is delivered, a copy of the documents incorporated by reference into this prospectus but not delivered with the prospectus. You may request a copy of these filings, and any exhibits we have specifically incorporated by reference as an exhibit in this prospectus, at no cost, by writing to us at the following address: Investor Relations Department, TransCode Therapeutics, Inc., 6 Liberty Square, #2382, Boston, Massachusetts 02109. These filings may also be obtained through our website located at https://www.transcodetherapeutics.com. The reference to our website is intended to be an inactive textual reference and, except for the documents incorporated by reference as noted above, the information on, or accessible through, our website is not intended to be part of this prospectus. You should rely only on the information incorporated by reference or provided in this prospectus. We have not authorized anyone else to provide you with different information. You should not assume that the information in this prospectus or in the documents incorporated by reference is accurate as of any date other than the date on the front of this prospectus or those documents.</font>
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    <div style="page-break-after:always; width:595.3pt;margin-left:auto;margin-right:auto;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Helvetica, Arial, sans-serif;font-size:9pt;">
      <div style="padding:0pt;margin:0pt;font-family:calibri, arial, sans-serif;font-weight:normal;font-style:normal;font-size:8pt;line-height:8pt;">
        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a>
      </div>
      <div style="margin-top:27.85pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
        <div style="width:456pt; line-height:12pt;font-family:Times New Roman, Times, serif ;font-size:10pt;">
          <font style="letter-spacing:0.2pt;">&#8199;</font>
        </div>
        <div style="position:relative;margin-top:62pt; text-align:center; width:456pt;">
          <img src="lg_transcodetheratm-4c.jpg" alt="[MISSING IMAGE: lg_transcodetheratm-4c.jpg]" height="59" width="403" >
        </div>
        <div style="margin-top:101pt; text-align:center; width:456pt; line-height:20pt;font-weight:bold;font-family:Times New Roman, Times, serif ;font-size:18pt;">
          <font style="letter-spacing:-0.36pt;">TransCode Therapeutics, Inc.</font><font style="font-weight:normal;letter-spacing:0.36pt;"> </font>
        </div>
        <div style="margin-top:72pt; text-align:center; width:456pt; line-height:16pt;font-weight:bold;font-family:Times New Roman, Times, serif ;font-size:14pt;">
          <font style="letter-spacing:-0.28pt;">173,033 Shares of Common Stock </font>
        </div>
        <div style="margin-top:6pt; text-align:center; width:456pt; line-height:16pt;font-weight:bold;font-family:Times New Roman, Times, serif ;font-size:14pt;">
          <font style="letter-spacing:-0.28pt;">470,007 shares of Common Stock underlying the Pre-Funded Warrants </font>
        </div>
        <div style="margin-top:6pt; text-align:center; width:456pt; line-height:16pt;font-weight:bold;font-family:Times New Roman, Times, serif ;font-size:14pt;">
          <font style="letter-spacing:-0.28pt;">Up to 4,050,953 shares of Common Stock underlying the Series&#160;C Warrants </font>
        </div>
        <div style="margin-top:6pt; text-align:center; width:456pt; line-height:16pt;font-weight:bold;font-family:Times New Roman, Times, serif ;font-size:14pt;">
          <font style="letter-spacing:-0.28pt;">Up to 12,152,856 shares of Common Stock underlying the Series&#160;D Warrants</font><font style="font-weight:normal;letter-spacing:0.28pt;"> </font>
        </div>
        <div style="margin-top:120pt; text-align:center; width:456pt; line-height:14pt;font-weight:bold;font-family:Times New Roman, Times, serif ;font-size:12pt;">
          <font style="letter-spacing:-0.24pt;">PROSPECTUS</font><font style="font-weight:normal;letter-spacing:0.24pt;"> </font>
        </div>
        <div style="margin-top:168pt; text-align:center; width:456pt; line-height:12pt;font-weight:bold;font-family:Times New Roman, Times, serif ;font-size:10pt;">
          <font style="letter-spacing:-0.2pt;">December&#8199;&#8199;&#8199;&#8199;&#8199;&#8199;, 2024</font>
        </div>
      </div>
      <hr >
    </div>
    <div style="page-break-after:always; width:595.3pt;margin-left:auto;margin-right:auto;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
      <div style="padding:0pt;margin:0pt;font-family:calibri, arial, sans-serif;font-weight:normal;font-style:normal;font-size:8pt;line-height:8pt;">
        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a>
      </div>
      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:6pt; width:456pt; line-height:14pt;font-size:12pt;">
          <font style="letter-spacing:0.24pt;">&#160;</font>
        </div>
        <div style="margin-top:5.833pt; width:456pt;">
          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
        </div>
      </div>
      <div style="margin-top:6pt;margin-left:69.66pt;width:456pt;">
        <div style="text-align:center; width:456pt; line-height:20pt;font-weight:bold;font-size:18pt;">
          <font style="letter-spacing:-0.36pt;">Part&#160;II</font><font style="font-weight:normal;letter-spacing:0.36pt;"> </font>
        </div>
        <div style="margin-top:6pt; text-align:center; width:456pt; line-height:20pt;font-weight:bold;font-size:18pt;">
          <font style="letter-spacing:-0.36pt;">Information not required in prospectus</font><font style="font-weight:normal;letter-spacing:0.36pt;"> </font>
        </div>
        <div style="margin-top:12pt; width:456pt; line-height:14pt;font-weight:bold;font-size:12pt;">
          <font style="letter-spacing:-0.24pt;">Item&#160;13.&nbsp;&nbsp;&nbsp;Other Expenses of Issuance and Distribution</font><font style="font-weight:normal;letter-spacing:0.24pt;"> </font>
        </div>
        <table style="width:456pt;margin-top:14pt;border-collapse: collapse;border-top:0.75pt solid #000000; font-style:normal;font-weight:bold;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
          <tr style="line-height:12pt;white-space:nowrap;text-align:left;vertical-align:bottom;font-style:normal;font-weight:bold;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="border-bottom:1px solid #FFFFFF;padding:0pt 0pt 0.5pt 0pt; width:398.59pt;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">&#8203;</td>
            <td style="border-bottom:1px solid #000000;padding:1.167pt 0pt 1.833pt 0pt;text-align:center;" colspan="4">
              <div style="text-align:center;">
                <font style="letter-spacing:-0.2pt;">Amount to</font>
                <br >
                <font style="letter-spacing:-0.2pt;">Be Paid </font>
              </div>
            </td>
            <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:10pt;background-color:#CCEEFF;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:2.75pt 0pt 2pt 0pt; width:398.59pt;text-align:left;">
              <div style="white-space:nowrap;">
                <font style="letter-spacing:0.2pt;">U.S. Securities and Exchange Commission registration fee </font>
              </div>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:0pt;width:0pt;">&#8203;</td>
            <td style="padding:2.75pt 0pt 2pt 0pt; min-width:3.75pt; text-align:right; ">$</td>
            <td style="padding:2.75pt 0pt 2pt 0pt; min-width:30.75pt; text-align:right; white-space:nowrap;">7,397.54 </td>
            <td style="padding:0pt;padding-left:0pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:10pt;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:3pt 0pt 2pt 0pt; width:398.59pt;text-align:left;">
              <div style="white-space:nowrap;">
                <font style="letter-spacing:0.2pt;">Legal fees and expenses </font>
              </div>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:0pt;width:0pt;">&#8203;</td>
            <td style="padding:3pt 0pt 2pt 0pt; min-width:3.75pt; text-align:right; ">$</td>
            <td style="padding:3pt 0pt 2pt 0pt; min-width:30.75pt; text-align:right; white-space:nowrap;">25,000</td>
            <td style="padding:0pt;padding-left:0pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:10pt;background-color:#CCEEFF;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:3pt 0pt 2pt 0pt; width:398.59pt;text-align:left;">
              <div style="white-space:nowrap;">
                <font style="letter-spacing:0.2pt;">Accounting fees and expenses </font>
              </div>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:0pt;width:0pt;">&#8203;</td>
            <td style="padding:3pt 0pt 2pt 0pt; min-width:3.75pt; text-align:right; ">$</td>
            <td style="padding:3pt 0pt 2pt 0pt; min-width:30.75pt; text-align:right; white-space:nowrap;">25,000</td>
            <td style="padding:0pt;padding-left:0pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:10pt;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:3pt 0pt 0.5pt 0pt; width:398.59pt;text-align:left;">
              <div style="white-space:nowrap;">
                <font style="letter-spacing:0.2pt;">Total </font>
              </div>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:0pt;width:0pt;">&#8203;</td>
            <td style="padding:3pt 0pt 0.5pt 0pt; min-width:3.75pt; text-align:right; ">$</td>
            <td style="padding:3pt 0pt 0.5pt 0pt; min-width:30.75pt; text-align:right; white-space:nowrap;">57,397.54</td>
            <td style="padding:0pt;padding-left:0pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:9pt;background-color:#CCEEFF;white-space:nowrap;text-align:center;vertical-align:bottom;">
            <td style="border-bottom:1px solid #000000;padding:0pt 0pt 2.5pt 0pt; width:398.59pt;text-align:left;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #000000; width:6pt;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #000000; width:6pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:0pt;width:0pt;border-bottom:1px solid #000000;">&#8203;</td>
            <td style="padding:0pt 0pt 2.5pt 0pt;border-bottom:1px solid #000000; min-width:3.75pt; text-align:right; ">&#8203;</td>
            <td style="padding:0pt 0pt 2.5pt 0pt;border-bottom:1px solid #000000; min-width:30.75pt; text-align:right; white-space:nowrap;">&#8203;</td>
            <td style="padding:0pt;padding-left:0pt;width:0pt;border-bottom:1px solid #000000;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #000000; width:0pt;">&#8203;</td>
          </tr>
        </table>
        <div style="margin-top:9.02pt; width:456pt; line-height:14pt;font-weight:bold;font-size:12pt;">
          <font style="letter-spacing:-0.24pt;">Item&#160;14.&nbsp;&nbsp;&nbsp;Indemnification of Directors and Officers</font><font style="font-weight:normal;letter-spacing:0.24pt;"> </font>
        </div>
        <div style="margin-top:12pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:0.2pt;">Under the General Corporation Law of the State of Delaware (&#8220;DGCL&#8221;), a corporation may include provisions in its certificate of incorporation that will relieve its directors of monetary liability for breaches of their fiduciary duty to the corporation, except under certain circumstances, including a breach of the director&#8217;s duty of loyalty, acts or omissions of the director not in good faith or which involve intentional misconduct or a knowing violation of law, the approval of an improper payment of a dividend or an improper purchase by the corporation of stock or any transaction from which the director derived an improper personal benefit. The Company&#8217;s Amended and Restated Certificate of Incorporation eliminates the personal liability of directors to the Company or its stockholders for monetary damages for breach of fiduciary duty as a director with certain limited exceptions set forth in the DGCL. </font>
        </div>
        <div style="margin-top:11.02pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:0.2pt;">Section&#160;145 of the DGCL grants to corporations the power to indemnify each officer and director against liabilities and expenses incurred by reason of the fact that he or she is or was an officer or director of the corporation if he or she acted in good faith and in a manner he or she reasonably believed to be in or not opposed to the best interests of the corporation and, with respect to any criminal action or proceeding, had no reasonable cause to believe his or her conduct was unlawful. The Company&#8217;s Amended and Restated Certificate of Incorporation and Bylaws provide for indemnification of each officer and director of the Company to the fullest extent permitted by the DGCL. Section&#160;145 also empowers corporations to purchase and maintain insurance on behalf of any person who is or was an officer or director of the corporation against liability asserted against or incurred by him in any such capacity, whether or not the corporation would have the power to indemnify such officer or director against such liability under the provisions of Section&#160;145. </font>
        </div>
        <div style="margin-top:10.91pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:0.2pt;">We have adopted provisions in our amended and restated certificate of incorporation and amended and restated bylaws to be in effect immediately prior to the completion of this offering that limit or eliminate the personal liability of our directors to the fullest extent permitted by the DGCL, as it now exists or may in the future be amended. Consequently, a director will not be personally liable to us or our stockholders for monetary damages or breach of fiduciary duty as a director, except for liability for any breach of the director&#8217;s duty of loyalty to us or our stockholders; any act or omission not in good faith or that involves intentional misconduct or a knowing violation of law; any unlawful payments related to dividends or unlawful stock purchases, redemptions or other distributions; or any transaction from which the director derived an improper personal benefit. </font>
        </div>
        <div style="margin-top:10.91pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:0.2pt;">These limitations of liability do not alter director liability under the federal securities laws and do not affect the availability of equitable remedies such as an injunction or rescission. </font>
        </div>
        <div style="margin-top:10.91pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">In addition, our bylaws provide that: </font>
        </div>
        <div style=" float:left; margin-left:20pt; line-height:12pt; margin-top:4.21pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="font-family:Times New Roman, Times, serif;">&#10146;</font>
          <br >
        </div>
        <div style=" margin-top:4.21pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:40pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">we will indemnify our directors, officers and, in the discretion of our board of directors, certain employees to the fullest extent permitted by the DGCL, as it now exists or may in the future be amended; and </font>
        </div>
        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
      </div>
      <div style="margin-top:2.00000000000002pt;height:12pt;margin-left:69.66pt;width:456pt;">
        <div style="text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">&#160;</font>
          <br >
        </div>
      </div>
      <div style="margin-top:2pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
        <div style="width:456pt;">
          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
        </div>
        <div style="margin-top:3pt; width:456pt; line-height:13pt;">
          <font style="letter-spacing:0.2pt;">II-1</font>
        </div>
      </div>
      <hr >
    </div>
    <div style="page-break-after:always; width:595.3pt;margin-left:auto;margin-right:auto;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
      <div style="padding:0pt;margin:0pt;font-family:calibri, arial, sans-serif;font-weight:normal;font-style:normal;font-size:8pt;line-height:8pt;">
        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a>
      </div>
      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:6pt; width:456pt; line-height:14pt;font-size:12pt;">
          <font style="letter-spacing:0.24pt;">Part II</font>
        </div>
        <div style="margin-top:5.833pt; width:456pt;">
          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
        </div>
      </div>
      <div style="margin-top:6pt;margin-bottom:340pt;margin-left:69.66pt;width:456pt;">
        <div style=" float:left; margin-left:20pt; line-height:12pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="font-family:Times New Roman, Times, serif;">&#10146;</font>
          <br >
        </div>
        <div style=" line-height:12pt; text-align:left; margin-left:40pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">we will advance reasonable expenses, including attorneys&#8217; fees, to our directors and, in the discretion of our board of directors, to our officers and certain employees, in connection with legal proceedings relating to their service for or on behalf of us, subject to limited exceptions. </font>
        </div>
        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">We intend to enter into indemnification agreements with each of our directors, executive officers, and other officers as determined from time to time by our board of directors or our remuneration committee. These agreements will provide that we will indemnify each of our directors, officers with whom we have entered into indemnification agreements, and, at times, their affiliates to the fullest extent permitted by Delaware law. </font>
        </div>
        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">We will advance expenses, including attorneys&#8217; fees (but excluding judgments, fines and settlement amounts), to each indemnified director, executive officer or affiliate in connection with any proceeding in which indemnification is available and we will indemnify our directors and officers for certain actions or proceedings arising out of that person&#8217;s services as a director or officer brought on behalf of us or in furtherance of our rights. Additionally, certain of our directors or officers may have certain rights to indemnification, advancement of expenses or insurance provided by their affiliates or other third-parties, which indemnification relates to and might apply to the same proceedings arising out of such director&#8217;s or officer&#8217;s services as a director referenced herein. Nonetheless, we will agree in the indemnification agreements that our obligations to those same directors or officers are primary and any obligation of such affiliates or other third-parties to advance expenses or to provide indemnification for the expenses or liabilities incurred by those directors are secondary. </font>
        </div>
        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">We will maintain general liability insurance which covers certain liabilities of our directors and officers arising out of claims based on acts or omissions in their capacities as directors or officers, including liabilities under the Securities Act of 1933, as amended, or the Securities Act. </font>
        </div>
      </div>
      <div style="margin-top:0pt;height:12pt;margin-left:69.66pt;width:456pt;">
        <div style="text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">&#160;</font>
          <br >
        </div>
      </div>
      <div style="margin-top:2pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
        <div style="width:456pt;">
          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
        </div>
        <div style="margin-top:3pt; text-align:right; width:456pt; line-height:13pt;">
          <font style="letter-spacing:0.2pt;">II-2</font>&#8203;</div>
      </div>
      <hr >
    </div>
    <div style="page-break-after:always; width:595.3pt;margin-left:auto;margin-right:auto;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
      <div style="padding:0pt;margin:0pt;font-family:calibri, arial, sans-serif;font-weight:normal;font-style:normal;font-size:8pt;line-height:8pt;">
        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a>
      </div>
      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:6pt; width:456pt; line-height:14pt;font-size:12pt;">
          <font style="letter-spacing:0.24pt;">Part II</font>
        </div>
        <div style="margin-top:5.833pt; width:456pt;">
          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
        </div>
      </div>
      <div style="margin-top:6pt;margin-bottom:122pt;margin-left:69.66pt;width:456pt;">
        <div style="width:456pt; line-height:14pt;font-weight:bold;font-size:12pt;">
          <font style="letter-spacing:-0.24pt;">Item&#160;15.&nbsp;&nbsp;&nbsp;Recent Sales of Unregistered Securities</font><font style="font-weight:normal;letter-spacing:0.24pt;"> </font>
        </div>
        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">In the three&#160;years preceding the filing of this registration statement, we have issued the following securities that were not registered under the Securities Act. No underwriters were involved in the sales and the certificates representing the securities sold and issued contain legends restricting transfer of the securities without registration under the Securities Act or an applicable exemption from registration. </font>
        </div>
        <div style=" float:left; margin-left:20pt; line-height:12pt; margin-top:12pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:0.2pt;">(a)</font>
          <br >
        </div>
        <div style=" margin-top:12pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:40pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">In February&#160;2023, in connection with an agreement we entered into with a consultant, we agreed to issue warrants to purchase up to 12,500 shares of common stock at $10.00 per share. These warrants are exercisable any time after six&#160;months from the effective date of the agreement (February&#160;23, 2023) through the fifth anniversary thereof, subject to our right in our sole discretion exercisable not later than August&#160;22, 2023, to reduce the number of warrants to 6,250. This right was exercised on May&#160;31, 2023. </font>
        </div>
        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; margin-left:20pt; line-height:12pt; margin-top:12pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:0.2pt;">(b)</font>
          <br >
        </div>
        <div style=" margin-top:12pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:40pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">In February&#160;2023, in connection with our registered direct offering, we issued as compensation to the placement agent in that transaction warrants to purchase up to 9,962 shares of common stock exercisable at $13.18 per share. These warrants are exercisable beginning six&#160;months after the closing of the offering and expire five&#160;years after issuance. </font>
        </div>
        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; margin-left:20pt; line-height:12pt; margin-top:12pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:0.2pt;">(c)</font>
          <br >
        </div>
        <div style=" margin-top:12pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:40pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">In December&#160;2023, in connection with our registered direct offering, we issued as compensation to the placement agent in that transaction warrants to purchase up to 300,000 shares of common stock exercisable at $0.3025 per share. These warrants are exercisable immediately after the closing of the offering and expire five&#160;years the date sales in the Offering commenced. </font>
        </div>
        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; margin-left:20pt; line-height:12pt; margin-top:12pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:0.2pt;">(d)</font>
          <br >
        </div>
        <div style=" margin-top:12pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:40pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">On July&#160;22, 2024, we entered into a Placement Agency Agreement (the &#8220;Agreement&#8221;) with ThinkEquity LLC (the &#8220;Placement Agent&#8221;), pursuant to which, as part of its compensation for acting as placement agent, we issued to the Placement Agent, warrants to purchase 500,000 shares of Common Stock (the &#8220;Placement Agent Warrants&#8221;). The Placement Agent Warrants are exercisable commencing January&#160;18, 2025, expire July&#160;22, 2029, and have an exercise price of $0.375 per share. </font>
        </div>
        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; margin-left:20pt; line-height:12pt; margin-top:12pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:0.2pt;">(e)</font>
          <br >
        </div>
        <div style=" margin-top:12pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:40pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">On November&#160;26, 2024, we entered into a Stock Purchase Agreement (the &#8220;PIPE Agreement&#8221;) with the Selling Stockholders pursuant to which we issued our Series&#160;C Warrants and Series&#160;D Warrants (together, the PIPE Warrants). The Series&#160;C Warrants are exercisable for five&#160;years after shareholder approval of the PIPE at an exercise price of $0.475 per share. The Series&#160;D Warrants are exercisable for two and one-half&#160;years after shareholder approval of the PIPE at an exercise price of $0.475 per share. </font>
        </div>
        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">The issuances of certain of the securities described above were deemed to be exempt from registration pursuant to Section&#160;4(a)(2) of the Securities Act or Rule&#160;701 promulgated under the Securities Act as transactions pursuant to compensatory benefit plans. The shares of common stock issued upon the exercise of options are deemed to be restricted securities for purposes of the Securities Act. </font>
        </div>
      </div>
      <div style="margin-top:0pt;height:12pt;margin-left:69.66pt;width:456pt;">
        <div style="text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">&#160;</font>
          <br >
        </div>
      </div>
      <div style="margin-top:2pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
        <div style="width:456pt;">
          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
        </div>
        <div style="margin-top:3pt; width:456pt; line-height:13pt;">
          <font style="letter-spacing:0.2pt;">II-3</font>
        </div>
      </div>
      <hr >
    </div>
    <div style="page-break-after:always; width:595.3pt;margin-left:auto;margin-right:auto;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;letter-spacing:0.2pt;font-family:Times New Roman, Times, serif ;font-size:10pt;">
      <div style="padding:0pt;margin:0pt;font-family:calibri, arial, sans-serif;font-weight:normal;font-style:normal;font-size:8pt;line-height:8pt;">
        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a>
      </div>
      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:6pt; width:456pt; line-height:14pt;font-size:12pt;">
          <font style="letter-spacing:0.24pt;">Part II</font>
        </div>
        <div style="margin-top:5.833pt; width:456pt;">
          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
        </div>
      </div>
      <div style="margin-top:6pt;margin-left:69.66pt;width:456pt;">
        <div style="width:456pt; line-height:14pt;font-weight:bold;font-size:12pt;">
          <font style="letter-spacing:-0.24pt;">Item&#160;16.&nbsp;&nbsp;&nbsp;Exhibits and Financial Statement Schedules</font><font style="font-weight:normal;letter-spacing:0.24pt;"> </font>
        </div>
        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">The Exhibit&#160;Index set forth below is incorporated by reference in response to this Item. </font>
        </div>
        <table style="width:456pt;height:598.5pt;margin-top:14pt;border-collapse: collapse;font-style:normal;font-weight:bold;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
          <tr style="line-height:12pt;white-space:nowrap;text-align:left;vertical-align:bottom;font-style:normal;font-weight:bold;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="border-bottom:1px solid #000000;padding:0pt 0pt 1.833pt 0pt; width:33.64pt;">
              <font style="letter-spacing:-0.2pt;">Exhibit </font>
              <br >
              <font style="letter-spacing:-0.2pt;">Number </font>
            </td>
            <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">&#8203;</td>
            <td style="border-bottom:1px solid #000000;padding:0pt 0pt 1.833pt 0pt; width:410.36pt;text-align:center;">
              <div style="white-space:nowrap; text-align:center;">
                <font style="letter-spacing:-0.2pt;">Description </font>
              </div>
            </td>
            <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:12pt;white-space:nowrap;text-align:left;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;letter-spacing:0.2pt;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:1.917pt 0pt 0.5pt 0pt; width:33.64pt;">
              <font style="margin-left:5pt;letter-spacing:0.2pt;">3.1 </font>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:1.917pt 0pt 0.5pt 0pt; width:410.36pt;white-space:normal;">
              <a style="-sec-extract:exhibit" href="https://www.sec.gov/Archives/edgar/data/1829635/000110465921029169/tm2038085d6_ex3-3.htm">Amended and Restated Certificate of Incorporation of TransCode Therapeutics, Inc. (Incorporated by reference to Exhibit&#160;3.3 to the Registrant&#8217;s Amendment No. 2 to Registration Statement on Form S-1, filed on April&#160;8, 2021 (File No. 333-253599)).</a>
            </td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:12pt;white-space:nowrap;text-align:left;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;letter-spacing:0.2pt;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:2.167pt 0pt 0.5pt 0pt; width:33.64pt;">
              <font style="margin-left:5pt;letter-spacing:0.2pt;">3.2 </font>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:2.167pt 0pt 0.5pt 0pt; width:410.36pt;white-space:normal;">
              <a style="-sec-extract:exhibit" href="https://www.sec.gov/Archives/edgar/data/1829635/000141057824000413/rnaz-20231231xex3d2.htm">Certificate of Amendment to Amended and Restated Certificate of Incorporation of TransCode Therapeutics, Inc. (Incorporated by reference to Exhibit&#160;3.2 to the Registrant&#8217;s Form 10-K for the year ended December&#160;31, 2023, filed on April&#160;1, 2024).</a>
            </td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:12pt;white-space:nowrap;text-align:left;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;letter-spacing:0.2pt;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:2.167pt 0pt 0.5pt 0pt; width:33.64pt;">
              <font style="margin-left:5pt;letter-spacing:0.2pt;">3.3 </font>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:2.167pt 0pt 0.5pt 0pt; width:410.36pt;white-space:normal;">
              <a style="-sec-extract:exhibit" href="https://www.sec.gov/Archives/edgar/data/1829635/000110465924004094/tm243329d1_ex3-1.htm">Certificate of Amendment to Amended and Restated Certificate of Incorporation of TransCode Therapeutics, Inc. (Incorporated by reference to Exhibit&#160;3.1 to the Registrant&#8217;s Current Report on Form 8-K, filed on January&#160;16, 2024).</a>
            </td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:12pt;white-space:nowrap;text-align:left;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;letter-spacing:0.2pt;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:2.167pt 0pt 0.5pt 0pt; width:33.64pt;">
              <font style="margin-left:5pt;letter-spacing:0.2pt;">3.4 </font>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:2.167pt 0pt 0.5pt 0pt; width:410.36pt;white-space:normal;">
              <a style="-sec-extract:exhibit" href="https://www.sec.gov/Archives/edgar/data/1829635/000110465924124097/tm2429720d2_ex3-1.htm">Certificate of Amendment to Amended and Restated Certificate of Incorporation of TransCode Therapeutics, Inc. (Incorporated by Reference to Exhibit&#160;3.1 to the Registrant&#8217;s Current Report on Form 8-K filed on November&#160;29, 2024).</a>
            </td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:12pt;white-space:nowrap;text-align:left;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;letter-spacing:0.2pt;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:2.167pt 0pt 0.5pt 0pt; width:33.64pt;">
              <font style="margin-left:5pt;letter-spacing:0.2pt;">3.5 </font>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:2.167pt 0pt 0.5pt 0pt; width:410.36pt;white-space:normal;">
              <a style="-sec-extract:exhibit" href="https://www.sec.gov/Archives/edgar/data/1829635/000110465921029169/tm2038085d6_ex3-5.htm">Amended and Restated Bylaws of TransCode Therapeutics, Inc. (Incorporated by reference to Exhibit&#160;3.5 to the Registrant&#8217;s Registration Statement on Form S-1, filed on February&#160;26, 2021 (File No. 333-253599)).</a>
            </td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:12pt;white-space:nowrap;text-align:left;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;letter-spacing:0.2pt;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:2.167pt 0pt 0.5pt 0pt; width:33.64pt;">
              <font style="margin-left:5pt;letter-spacing:0.2pt;">3.6 </font>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:2.167pt 0pt 0.5pt 0pt; width:410.36pt;white-space:normal;">
              <a style="-sec-extract:exhibit" href="https://www.sec.gov/Archives/edgar/data/1829635/000110465923124739/tm2332527d1_ex3-1.htm">Amendment No. 1 to the Amended and Restated Bylaws of TransCode Therapeutics, Inc., effective as of December&#160;8, 2023 (Incorporated by reference to Exhibit&#160;3.1 to the Registrant&#8217;s Current Report on Form 8-K, filed on December&#160;8, 2023).</a>
            </td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:12pt;white-space:nowrap;text-align:left;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:2.167pt 0pt 0.5pt 0pt; width:33.64pt;">
              <font style="margin-left:5pt;letter-spacing:0.2pt;">4.1 </font>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:2.167pt 0pt 0.5pt 0pt; width:410.36pt;white-space:normal;">
              <a style="-sec-extract:exhibit" href="https://www.sec.gov/Archives/edgar/data/1829635/000110465924124597/tm2429720d1_ex4-1.htm">Form of Pre-funded Warrant (Incorporated by reference to Exhibit&#160;4.1 to the Registrant&#8217;s Current Report on Form 8-K, filed on December&#160;2, 2024).</a>
            </td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:12pt;white-space:nowrap;text-align:left;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;letter-spacing:0.2pt;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:2.167pt 0pt 0.5pt 0pt; width:33.64pt;">
              <font style="margin-left:5pt;letter-spacing:0.2pt;">4.2 </font>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:2.167pt 0pt 0.5pt 0pt; width:410.36pt;white-space:normal;">
              <a style="-sec-extract:exhibit" href="https://www.sec.gov/Archives/edgar/data/1829635/000110465924124597/tm2429720d1_ex4-2.htm">Form of Series C Warrant (Incorporated by reference to Exhibit&#160;4.2 to the Registrant&#8217;s Current Report on Form 8-K, filed on December&#160;2, 2024).</a>
            </td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:12pt;white-space:nowrap;text-align:left;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;letter-spacing:0.2pt;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:2.167pt 0pt 0.5pt 0pt; width:33.64pt;">
              <font style="margin-left:5pt;letter-spacing:0.2pt;">4.3 </font>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:2.167pt 0pt 0.5pt 0pt; width:410.36pt;white-space:normal;">
              <a style="-sec-extract:exhibit" href="https://www.sec.gov/Archives/edgar/data/1829635/000110465924124597/tm2429720d1_ex4-3.htm">Form of Series D Warrant (Incorporated by reference to Exhibit&#160;4.3 to the Registrant&#8217;s Current Report on Form 8-K, filed on December&#160;2, 2024).</a>
            </td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:10pt;white-space:nowrap;text-align:left;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:3.5pt 0pt 0.5pt 0pt; width:33.64pt;">
              <font style="margin-left:5pt;letter-spacing:0.2pt;">5.1</font><font style="letter-spacing:0.2pt;">*</font>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 0.5pt 0pt; width:410.36pt;">
              <a style="-sec-extract:exhibit" href="tm2430338d2_ex5-1.htm">Opinion of Goodwin Procter LLP.</a>
            </td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:12pt;white-space:nowrap;text-align:left;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;letter-spacing:0.2pt;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:2.167pt 0pt 0.5pt 0pt; width:33.64pt;">
              <font style="letter-spacing:0.2pt;">10.1# </font>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:2.167pt 0pt 0.5pt 0pt; width:410.36pt;white-space:normal;">
              <a style="-sec-extract:exhibit" href="https://www.sec.gov/Archives/edgar/data/1829635/000110465921029169/tm2038085d6_ex10-1.htm">2020 Stock Option and Incentive Plan and form of award agreements thereunder (Incorporated by reference to Exhibit&#160;10.1 to the Registrant&#8217;s Registration Statement on Form&#160;S-1, filed on February&#160;26, 2021 (File No. 333-253599).</a>
            </td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:12pt;white-space:nowrap;text-align:left;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;letter-spacing:0.2pt;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:2.167pt 0pt 0.5pt 0pt; width:33.64pt;">
              <font style="letter-spacing:0.2pt;">10.2# </font>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:2.167pt 0pt 0.5pt 0pt; width:410.36pt;white-space:normal;">
              <a style="-sec-extract:exhibit" href="https://www.sec.gov/Archives/edgar/data/1829635/000110465921040777/tm2038085d9_ex10-2.htm">2021 Stock Option and Incentive Plan and form of award agreements thereunder (Incorporated by reference to Exhibit&#160;10.2 to the Registrant&#8217;s Amendment No. 1 to Registration Statement on Form S-1, filed on March&#160;24, 2021 (File No. 333-253599).</a>
            </td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:12pt;white-space:nowrap;text-align:left;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;letter-spacing:0.2pt;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:2.167pt 0pt 0.5pt 0pt; width:33.64pt;">
              <font style="letter-spacing:0.2pt;">10.3# </font>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:2.167pt 0pt 0.5pt 0pt; width:410.36pt;white-space:normal;">
              <a style="-sec-extract:exhibit" href="https://www.sec.gov/Archives/edgar/data/1829635/000110465921040777/tm2038085d9_ex10-3.htm">Senior Executive Cash Incentive Bonus Plan (Incorporated by reference to Exhibit&#160;10.3 to the Registrant&#8217;s Amendment No. 1 to Registration Statement on Form S-1, filed on March&#160;24, 2021 (File No. 333-253599).</a>
            </td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:12pt;white-space:nowrap;text-align:left;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;letter-spacing:0.2pt;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:2.167pt 0pt 0.5pt 0pt; width:33.64pt;">
              <font style="letter-spacing:0.2pt;">10.4# </font>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:2.167pt 0pt 0.5pt 0pt; width:410.36pt;white-space:normal;">
              <a style="-sec-extract:exhibit" href="https://www.sec.gov/Archives/edgar/data/1829635/000110465921040777/tm2038085d9_ex10-4.htm">Form of Indemnification Agreement between the Registrant and each of its executive officers (Incorporated by reference to Exhibit&#160;10.4 to the Registrant&#8217;s Amendment No. 1 to Registration Statement on Form S-1, filed on March&#160;24, 2021 (File No. 333-253599).</a>
            </td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:12pt;white-space:nowrap;text-align:left;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;letter-spacing:0.2pt;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:2.167pt 0pt 0.5pt 0pt; width:33.64pt;">
              <font style="letter-spacing:0.2pt;">10.5# </font>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:2.167pt 0pt 0.5pt 0pt; width:410.36pt;white-space:normal;">
              <a style="-sec-extract:exhibit" href="https://www.sec.gov/Archives/edgar/data/1829635/000110465921040777/tm2038085d9_ex10-5.htm">Form of Indemnification Agreement between the Registrant and each of its directors (Incorporated by reference to Exhibit&#160;10.5 to the Registrant&#8217;s Amendment No. 1 to Registration Statement on Form S-1, filed on March&#160;24, 2021 (File No. 333-253599)).</a>
            </td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:12pt;white-space:nowrap;text-align:left;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:2.167pt 0pt 0.5pt 0pt; width:33.64pt;">
              <font style="letter-spacing:0.2pt;">10.6&#8224; </font>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:2.167pt 0pt 0.5pt 0pt; width:410.36pt;white-space:normal;">
              <a style="-sec-extract:exhibit" href="https://www.sec.gov/Archives/edgar/data/1829635/000110465921029169/tm2038085d6_ex10-7.htm">Exclusive Patent License Agreement by and between TransCode Therapeutics, Inc. and The General Hospital Corporation, d/b/a Massachusetts General Hospital, dated as of October&#160;26, 2018 (Incorporated by reference to Exhibit&#160;10.7 to the Registrant&#8217;s Registration Statement on Form S-1, filed on February&#160;26, 2021 (File No. 333-253599)).</a>
            </td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
        </table>
      </div>
      <div style="margin-top:2.00000000000002pt;height:12pt;margin-left:69.66pt;width:456pt;">
        <div style="text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">&#160;</font>
          <br >
        </div>
      </div>
      <div style="margin-top:2pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
        <div style="width:456pt;">
          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
        </div>
        <div style="margin-top:3pt; text-align:right; width:456pt; line-height:13pt;">
          <font style="letter-spacing:0.2pt;">II-4</font>&#8203;</div>
      </div>
      <hr >
    </div>
    <div style="page-break-after:always; width:595.3pt;margin-left:auto;margin-right:auto;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
      <div style="padding:0pt;margin:0pt;font-family:calibri, arial, sans-serif;font-weight:normal;font-style:normal;font-size:8pt;line-height:8pt;">
        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a>
      </div>
      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:6pt; width:456pt; line-height:14pt;font-size:12pt;">
          <font style="letter-spacing:0.24pt;">Part II</font>
        </div>
        <div style="margin-top:5.833pt; width:456pt;">
          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
        </div>
      </div>
      <div style="margin-top:6pt;margin-left:69.66pt;width:456pt;">
        <table style="width:456pt;margin-top:0pt;border-collapse: collapse;font-style:normal;font-weight:bold;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
          <tr style="line-height:12pt;white-space:nowrap;text-align:left;vertical-align:bottom;font-style:normal;font-weight:bold;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="border-bottom:1px solid #000000;padding:0pt 0pt 1.833pt 0pt; width:33.64pt;">
              <div style="text-align:justify;">
                <font style="letter-spacing:-0.2pt;">Exhibit </font>
                <br >
                <font style="letter-spacing:-0.2pt;">Number </font>
              </div>
            </td>
            <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">&#8203;</td>
            <td style="border-bottom:1px solid #000000;padding:0pt 0pt 1.833pt 0pt; width:410.36pt;text-align:center;">
              <div style="white-space:nowrap; text-align:center;">
                <font style="letter-spacing:-0.2pt;">Description </font>
              </div>
            </td>
            <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:12pt;white-space:nowrap;text-align:left;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;letter-spacing:0.2pt;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:1.917pt 0pt 0.833pt 0pt; width:33.64pt;">
              <font style="letter-spacing:0.2pt;">10.7&#8224; </font>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:1.917pt 0pt 0.833pt 0pt; width:410.36pt;white-space:normal;">
              <a style="-sec-extract:exhibit" href="https://www.sec.gov/Archives/edgar/data/1829635/000110465921029169/tm2038085d6_ex10-8.htm">First Amendment to Exclusive Patent License Agreement by and between TransCode Therapeutics, Inc. and The General Hospital Corporation, d/b/a Massachusetts General Hospital, dated as of October&#160;30, 2020 (Incorporated by reference to Exhibit&#160;10.8 to the Registrant&#8217;s Registration Statement on Form S-1, filed on February&#160;26, 2021 (File No.&#160;333-253599)).</a>
            </td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:12pt;white-space:nowrap;text-align:left;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;letter-spacing:0.2pt;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:2.167pt 0pt 0.833pt 0pt; width:33.64pt;">
              <font style="letter-spacing:0.2pt;">10.8# </font>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:2.167pt 0pt 0.833pt 0pt; width:410.36pt;white-space:normal;">
              <a style="-sec-extract:exhibit" href="https://www.sec.gov/Archives/edgar/data/1829635/000110465921040777/tm2038085d9_ex10-8.htm">2021 Employee Stock Purchase Plan (Incorporated by reference to Exhibit&#160;10.8 to the Registrant&#8217;s Registration Statement on Form S-1, filed on March&#160;24, 2021 (File No. 333-253599)).</a>
            </td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:12pt;white-space:nowrap;text-align:left;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;letter-spacing:0.2pt;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:2.167pt 0pt 0.833pt 0pt; width:33.64pt;">
              <font style="letter-spacing:0.2pt;">10.9# </font>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:2.167pt 0pt 0.833pt 0pt; width:410.36pt;white-space:normal;">
              <a style="-sec-extract:exhibit" href="https://www.sec.gov/Archives/edgar/data/1829635/000110465924004094/tm243329d1_ex10-1.htm">Separation Agreement, dated January&#160;10, 2024, by and between TransCode Therapeutics, Inc. and Robert Michael Dudley (Incorporated by reference to Exhibit&#160;10.1 to the Registrant&#8217;s Current Report on Form 8-K, filed on January&#160;16, 2024).</a>
            </td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:12pt;white-space:nowrap;text-align:left;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;letter-spacing:0.2pt;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:2.167pt 0pt 0.833pt 0pt; width:33.64pt;">
              <font style="letter-spacing:0.2pt;">10.10# </font>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:2.167pt 0pt 0.833pt 0pt; width:410.36pt;white-space:normal;">
              <a style="-sec-extract:exhibit" href="https://www.sec.gov/Archives/edgar/data/1829635/000110465921047837/tm2038085d12_ex10-11.htm">Employment Agreement, dated as of March&#160;24, 2021, by and Between TransCode Therapeutics, Inc. and Thomas A. Fitzgerald (Incorporated by reference to Exhibit&#160;10.11 to the Registrant&#8217;s Amendment No. 2 to Registration Statement on Form S-1, filed on April&#160;8, 2021 (File No. 333-253599)).</a>
            </td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:12pt;white-space:nowrap;text-align:left;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;letter-spacing:0.2pt;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:2.167pt 0pt 0.833pt 0pt; width:33.64pt;">
              <font style="letter-spacing:0.2pt;">10.11# </font>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:2.167pt 0pt 0.833pt 0pt; width:410.36pt;white-space:normal;">
              <a style="-sec-extract:exhibit" href="https://www.sec.gov/Archives/edgar/data/1829635/000110465921047837/tm2038085d12_ex10-12.htm">Letter Agreement, dated as of March&#160;24, 2021, by and Between TransCode Therapeutics, Inc. and Thomas A. Fitzgerald (Incorporated by reference to Exhibit&#160;10.12 to the Registrant&#8217;s Amendment No. 2 to Registration Statement on Form S-1, filed on April&#160;8, 2021 (File No.&#160;333-253599)).</a>
            </td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:12pt;white-space:nowrap;text-align:left;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:2.167pt 0pt 0.833pt 0pt; width:33.64pt;">
              <font style="letter-spacing:0.2pt;">10.12 </font>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:2.167pt 0pt 0.833pt 0pt; width:410.36pt;white-space:normal;">
              <div style="letter-spacing:0.2pt;">
                <a style="-sec-extract:exhibit" href="https://www.sec.gov/Archives/edgar/data/1829635/000110465924124597/tm2429720d1_ex10-1.htm">Form of Securities Purchase Agreement (Incorporated by reference to Exhibit&#160;10.1 to the Registrant&#8217;s Current Report on Form 8-K, filed on December&#160;2, 2024) .</a>
              </div>
            </td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:12pt;white-space:nowrap;text-align:left;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:2.167pt 0pt 0.833pt 0pt; width:33.64pt;">
              <font style="letter-spacing:0.2pt;">10.13 </font>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:2.167pt 0pt 0.833pt 0pt; width:410.36pt;white-space:normal;">
              <div style="letter-spacing:0.2pt;">
                <a style="-sec-extract:exhibit" href="https://www.sec.gov/Archives/edgar/data/1829635/000110465924124597/tm2429720d1_ex10-2.htm">Form of Registration Rights Agreement (Incorporated by reference to Exhibit&#160;10.2 to the Registrant&#8217;s Current Report on Form 8-K, filed on December&#160;2, 2024)</a>
              </div>
            </td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:10pt;white-space:nowrap;text-align:left;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:3.5pt 0pt 1.5pt 0pt; width:33.64pt;">
              <font style="letter-spacing:0.2pt;">23.1* </font>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; width:410.36pt;">
              <div style="letter-spacing:0.2pt;">
                <a style="-sec-extract:exhibit" href="tm2430338d2_ex23-1.htm">Consent of Withum Smith+Brown, PC, independent registered public accounting firm.</a>
              </div>
            </td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:10pt;white-space:nowrap;text-align:left;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:3.5pt 0pt 1.5pt 0pt; width:33.64pt;">
              <font style="letter-spacing:0.2pt;">23.2*</font>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; width:410.36pt;">
              <div style="letter-spacing:0.2pt;">
                <a style="-sec-extract:exhibit" href="tm2430338d2_ex5-1.htm">Consent of Goodwin Procter LLP (included in Exhibit&#160;5.1).</a>
              </div>
            </td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:10pt;white-space:nowrap;text-align:left;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:3.5pt 0pt 1.5pt 0pt; width:33.64pt;">
              <font style="letter-spacing:0.2pt;">24.1 </font>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; width:410.36pt;">
              <div style="letter-spacing:0.2pt;">
                <a href="#tSIG">Power of Attorney (included on signature page).</a>
              </div>
            </td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:10pt;white-space:nowrap;text-align:left;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:3.5pt 0pt 1.5pt 0pt; width:33.64pt;">
              <font style="letter-spacing:0.2pt;">104 </font>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; width:410.36pt;">
              <font style="letter-spacing:0.2pt;">Cover Page Interactive Data File (formatted as Inline XBRL and contained in Exhibit&#160;101) </font>
            </td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:10pt;white-space:nowrap;text-align:left;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="border-bottom:1px solid #000000;padding:3.5pt 0pt 2.5pt 0pt; width:33.64pt;">
              <font style="letter-spacing:0.2pt;">107*</font>
            </td>
            <td style="padding:0pt;border-bottom:1px solid #000000; width:6pt;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #000000; width:6pt;">&#8203;</td>
            <td style="border-bottom:1px solid #000000;padding:3.5pt 0pt 2.5pt 0pt; width:410.36pt;">
              <div style="letter-spacing:0.2pt;">
                <a style="-sec-extract:exhibit" href="tm2430338d2_ex-filingfees.htm">Filing Fee Table.</a>
              </div>
            </td>
            <td style="padding:0pt;border-bottom:1px solid #000000; width:0pt;">&#8203;</td>
          </tr>
        </table>
        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:7.9pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:0.2pt;">#</font>
          <br >
        </div>
        <div style=" margin-top:7.9pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">Indicates a management contract or any compensatory plan, contract or arrangement. </font>
        </div>
        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:3.9pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:0.2pt;">*</font>
          <br >
        </div>
        <div style=" margin-top:3.9pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">Filed herewith. </font>
        </div>
        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:3.9pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:0.2pt;">&#8224;</font>
          <br >
        </div>
        <div style=" margin-top:3.9pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">Portions of this exhibit (indicated by asterisks) were omitted in accordance with the rules of the Securities and Exchange Commission. </font>
        </div>
        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:11.9pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:0.2pt;">(b)</font>
          <br >
        </div>
        <div style=" margin-top:11.9pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">Financial Statements Schedules: None. </font>
        </div>
        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style="margin-top:12pt; width:456pt; line-height:14pt;font-weight:bold;font-size:12pt;">
          <font style="letter-spacing:-0.24pt;">Item&#160;17.&nbsp;&nbsp;&nbsp;Undertakings</font><font style="font-weight:normal;letter-spacing:0.24pt;"> </font>
        </div>
        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">The undersigned registrant hereby undertakes: </font>
        </div>
        <div style=" float:left; line-height:12pt; margin-top:11.9pt; margin-bottom:0pt; text-align:left; width:29pt;white-space:nowrap;">
          <font style="letter-spacing:0.2pt;">(a)(1)</font>
          <br >
        </div>
        <div style=" margin-top:11.9pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:29pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement: </font>
        </div>
        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; margin-left:40pt; line-height:12pt; margin-top:11.91pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:0.2pt;">(i)</font>
          <br >
        </div>
        <div style=" margin-top:11.91pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:60pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">To include any prospectus required by Section&#160;10(a)(3) of the Securities Act of 1933, as amended (the &#8220;Securities Act&#8221;); </font>
        </div>
        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; margin-left:40pt; line-height:12pt; margin-top:12pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:0.2pt;">(ii)</font>
          <br >
        </div>
        <div style=" margin-top:12pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:60pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in the volume of securities </font>
        </div>
        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
      </div>
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        <div style="text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">&#160;</font>
          <br >
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      <div style="margin-top:2pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
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          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
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        <div style="margin-top:3pt; width:456pt; line-height:13pt;">
          <font style="letter-spacing:0.2pt;">II-5</font>
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      </div>
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        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a>
      </div>
      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:6pt; width:456pt; line-height:14pt;font-size:12pt;">
          <font style="letter-spacing:0.24pt;">Part II</font>
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        <div style="margin-top:5.833pt; width:456pt;">
          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
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        <div style="margin-left:60pt; width:396pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule&#160;424(b) if, in the aggregate, the changes in volume and price represent no more than 20% change in the maximum aggregate offering price set forth in the &#8220;Calculation of Registration Fee&#8221; table in the effective registration statement; and </font>
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        <div style=" float:left; margin-left:40pt; line-height:12pt; margin-top:12.2pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:0.2pt;">(iii)</font>
          <br >
        </div>
        <div style=" margin-top:12.2pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:60pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">To include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration statement; </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">provided, however, that paragraphs (1)(i), (1)(ii) and (1)(iii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in reports filed with or furnished to the Commission by the registrant pursuant to Section&#160;13 or Section&#160;15(d) of the Securities Exchange Act of 1934, as amended (the &#8220;Exchange Act&#8221;), that are incorporated by reference in the registration statement, or is contained in a form of prospectus filed pursuant to Rule&#160;424(b) that is part of the registration statement. </font>
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        <div style=" float:left; margin-left:20pt; line-height:12pt; margin-top:12.1pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:0.2pt;">(2)</font>
          <br >
        </div>
        <div style=" margin-top:12.1pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:40pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">That, for the purposes of determining any liability under the Securities Act, each such post- effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at the time shall be deemed to be the initial bona fide offering thereof. </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; margin-left:20pt; line-height:12pt; margin-top:12.09pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:0.2pt;">(3)</font>
          <br >
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        <div style=" margin-top:12.09pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:40pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering. </font>
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        <div style=" float:left; margin-left:20pt; line-height:12pt; margin-top:12.1pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:0.2pt;">(4)</font>
          <br >
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        <div style=" margin-top:12.1pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:40pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">That, for the purpose of determining liability of the registrant under the Securities Act to any purchaser in the initial distribution of the securities, the undersigned registrant undertakes that in a primary offering of securities of the undersigned registrant pursuant to this registration statement, regardless of the underwriting method used to sell the securities to the purchaser, if the securities are offered or sold to such purchaser by means of any of the following communications, the undersigned registrant will be a seller to the purchaser and will be considered to offer or sell such securities to such purchaser: </font>
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        <div style=" float:left; margin-left:40pt; line-height:12pt; margin-top:12.1pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:0.2pt;">(i)</font>
          <br >
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        <div style=" margin-top:12.1pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:60pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">Any preliminary prospectus or prospectus of the undersigned registrant relating to the offering required to be filed pursuant to Rule&#160;424; </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; margin-left:40pt; line-height:12pt; margin-top:12.1pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:0.2pt;">(ii)</font>
          <br >
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        <div style=" margin-top:12.1pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:60pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">Any free writing prospectus relating to the offering prepared by or on behalf of the undersigned registrant or used or referred to by the undersigned registrant; </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; margin-left:40pt; line-height:12pt; margin-top:12.1pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:0.2pt;">(iii)</font>
          <br >
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        <div style=" margin-top:12.1pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:60pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">The portion of any other free writing prospectus relating to the offering containing material information about the undersigned registrant or its securities provided by or on behalf of the undersigned registrant; and </font>
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        <div style=" float:left; margin-left:40pt; line-height:12pt; margin-top:12.1pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:0.2pt;">(iv)</font>
          <br >
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        <div style=" margin-top:12.1pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:60pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">Any other communication that is an offer in the offering made by the undersigned registrant to the purchaser. </font>
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        <div style=" float:left; margin-left:20pt; line-height:12pt; margin-top:12.09pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:0.2pt;">(5)</font>
          <br >
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        <div style=" margin-top:12.09pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:40pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">That, for purposes of determining any liability under the Securities Act: </font>
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        <div style=" float:left; margin-left:40pt; line-height:12pt; margin-top:12.1pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:0.2pt;">(i)</font>
          <br >
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        <div style=" margin-top:12.1pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:60pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">the information omitted from the form of prospectus filed as part of the registration statement in reliance upon Rule&#160;430A and contained in the form of prospectus filed by the Registrant pursuant to Rule&#160;424(b)(1) or (4)&#160;or 497(h) under the Securities Act shall be deemed to be part of the registration statement as of the time it was declared effective; and </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; margin-left:40pt; line-height:12pt; margin-top:12.1pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:0.2pt;">(ii)</font>
          <br >
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        <div style=" margin-top:12.1pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:60pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">each post-effective amendment that contains a form of prospectus shall be deemed to be a </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
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        <div style="text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">&#160;</font>
          <br >
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      <div style="margin-top:2pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
        <div style="width:456pt;">
          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
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        <div style="margin-top:3pt; text-align:right; width:456pt; line-height:13pt;">
          <font style="letter-spacing:0.2pt;">II-6</font>&#8203;</div>
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        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a>
      </div>
      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:6pt; width:456pt; line-height:14pt;font-size:12pt;">
          <font style="letter-spacing:0.24pt;">Part II</font>
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        <div style="margin-top:5.833pt; width:456pt;">
          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
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        <div style="margin-left:60pt; width:396pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof. </font>
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        <div style=" float:left; line-height:12pt; margin-top:12pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:0.2pt;">(b)</font>
          <br >
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        <div style=" margin-top:12pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">The undersigned registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the registrant&#8217;s annual report pursuant to Section&#160;13(a) or 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit plan&#8217;s annual report pursuant to Section&#160;15(d) of the Exchange Act) that is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof. </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:12pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:0.2pt;">(c)</font>
          <br >
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        <div style=" margin-top:12pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the registrant pursuant to the indemnification provisions described herein, or otherwise, the registrant has been advised that in the opinion of the SEC such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.</font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
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      <div style="margin-top:0pt;height:12pt;margin-left:69.66pt;width:456pt;">
        <div style="text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">&#160;</font>
          <br >
        </div>
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      <div style="margin-top:2pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
        <div style="width:456pt;">
          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
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        <div style="margin-top:3pt; width:456pt; line-height:13pt;">
          <font style="letter-spacing:0.2pt;">II-7</font>
        </div>
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      <hr >
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    <div style=" width:595.3pt;margin-left:auto;margin-right:auto;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
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        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a><a name="tSIG">&#8203;</a>
      </div>
      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:6pt; width:456pt; line-height:14pt;font-size:12pt;">
          <font style="letter-spacing:0.24pt;">&#160;</font>
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        <div style="margin-top:5.833pt; width:456pt;">
          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
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      <div style="margin-top:6pt;margin-bottom:28.5pt;margin-left:69.66pt;width:456pt;">
        <div style="text-align:center; width:456pt; line-height:20pt;font-weight:bold;font-size:18pt;">
          <font style="letter-spacing:-0.36pt;">S</font><font style="text-transform:lowercase;letter-spacing:-0.36pt;">IGNATURES</font><font style="font-weight:normal;letter-spacing:0.36pt;"> </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">Pursuant to the requirements of the Securities Act of 1933, the registrant has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Boston, Commonwealth of Massachusetts, on the 6th day of December&#160;2024. </font>
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        <div style="margin-left:240pt; margin-top:12pt; width:216pt; line-height:12pt;font-weight:bold;">
          <font style="letter-spacing:-0.2pt;">TRANSCODE THERAPEUTICS, INC.</font><font style="font-weight:normal;letter-spacing:0.2pt;"> </font>
        </div>
        <div style=" float:left; margin-left:240pt; line-height:12pt; margin-top:12pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:0.2pt;">By:</font>
          <br >
        </div>
        <div style=" margin-top:12pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:260pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:0.2pt;">/s/ Thomas A. Fitzgerald</font>
        </div>
        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style="white-space:nowrap; margin-left:260pt; margin-top:2.5pt; width:196pt;">
          <div style="margin-left: 0pt; width: 196pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
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        <div style="margin-left:260pt; margin-top:2pt; width:196pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">Thomas A. Fitzgerald </font>
          <br >
          <font style="font-style:italic;letter-spacing:0.2pt;">Interim Chief Executive Officer</font><font style="letter-spacing:0.2pt;"> </font>
        </div>
        <div style="margin-top:12pt; text-align:center; width:456pt; line-height:20pt;font-weight:bold;font-size:18pt;">
          <font style="letter-spacing:-0.36pt;">P</font><font style="text-transform:lowercase;letter-spacing:-0.36pt;">OWER OF</font><font style="letter-spacing:-0.36pt;"> A</font><font style="text-transform:lowercase;letter-spacing:-0.36pt;">TTORNEY</font><font style="font-weight:normal;letter-spacing:0.36pt;"> </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">Each individual whose signature appears below hereby constitutes and appoints Thomas A. Fitzgerald as such person&#8217;s true and lawful attorney-in-fact and agent with full power of substitution and re-substitution, for such person in such person&#8217;s name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement (or any Registration Statement for the same offering that is to be effective upon filing pursuant to Rule&#160;462(b) under the Securities Act of 1933), and to file the same, with all exhibits thereto, and all documents in connection therewith, with the Securities and Exchange Commission granting unto each said attorney-in-fact and agent full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as such person might or could do in person, hereby ratifying and confirming all that any said attorney-in-fact and agent, or any substitute or substitutes of any of them, may lawfully do or cause to be done by virtue hereof. </font>
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        <div style="margin-top:12pt; width:456pt; line-height:10pt;">
          <font style="letter-spacing:0.2pt;">Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement and Power of Attorney has been signed by the following person in the capacities and on the date indicated. </font>
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        <table style="width:468pt;height:222pt;margin-top:2pt;border-collapse: collapse;font-style:normal;font-weight:bold;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
          <tr style="line-height:10pt;white-space:nowrap;text-align:left;vertical-align:bottom;">
            <td style="border-bottom:1px solid #000000;padding:0pt 0pt 1pt 0pt; width:0pt;" colspan="7">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">&#8203;</td>
            <td colspan="3">&#8203;</td>
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          <tr style="line-height:10pt;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:bold;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="border-bottom:1px solid #000000;padding:4.5pt 0pt 2.5pt 0pt; width:144pt;">
              <div style="white-space:nowrap; text-align:center;">
                <font style="letter-spacing:-0.2pt;">Name </font>
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            <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">&#8203;</td>
            <td style="border-bottom:1px solid #000000;padding:4.5pt 0pt 2.5pt 0pt; width:204pt;">
              <div style="white-space:nowrap; text-align:center;">
                <font style="letter-spacing:-0.2pt;">Title </font>
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            <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">&#8203;</td>
            <td style="border-bottom:1px solid #000000;padding:4.5pt 0pt 2.5pt 0pt; width:84pt;">
              <div style="white-space:nowrap; text-align:center;">
                <font style="letter-spacing:-0.2pt;">Date </font>
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            <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">&#8203;</td>
            <td colspan="3">&#8203;</td>
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          <tr style="line-height:12pt;height:56.5pt; white-space:normal;text-align:left;vertical-align:middle;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:20.167pt 0pt 1.833pt 0pt; width:144pt;">
              <div>
                <font style="letter-spacing:0.2pt;">/s/ Thomas A. Fitzgerald</font>
              </div>
              <div style="margin-top:2.5pt; text-align:justify;">
                <div style="margin-left: 0pt; width: 144pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
              </div>
              <div style="margin-top:2pt;">
                <font style="letter-spacing:0.2pt;">Thomas A. Fitzgerald </font>
              </div>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:20.167pt 0pt 1.833pt 0pt; width:204pt;">
              <div style="font-style:italic;">
                <font style="letter-spacing:0.2pt;">Director, Interim Chief Executive Officer and Chief Financial Officer (Principal Executive, Financial and Accounting Officer)</font>
              </div>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:20.167pt 0pt 1.833pt 0pt; width:84pt;white-space:nowrap;">
              <font style="letter-spacing:0.2pt;">December 6, 2024 </font>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td colspan="3">&#8203;</td>
          </tr>
          <tr style="line-height:12pt;height:46pt; white-space:nowrap;text-align:left;vertical-align:middle;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:20.167pt 0pt 1pt 0pt; width:144pt;white-space:normal;">
              <div>
                <font style="letter-spacing:0.2pt;">/s/ Philippe P. Calais</font>
              </div>
              <div style="margin-top:2.5pt; text-align:justify;">
                <div style="margin-left: 0pt; width: 144pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
              </div>
              <div style="margin-top:2pt;">
                <font style="letter-spacing:0.2pt;">Philippe P. Calais, PhD </font>
              </div>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:20.167pt 0pt 1pt 0pt; width:204pt;">
              <div style="font-style:italic;">
                <font style="letter-spacing:0.2pt;">Director</font>
              </div>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:20.167pt 0pt 1pt 0pt; width:84pt;">
              <font style="letter-spacing:0.2pt;">December 6, 2024 </font>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td colspan="3">&#8203;</td>
          </tr>
          <tr style="line-height:12pt;height:46pt; white-space:nowrap;text-align:left;vertical-align:middle;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:20.167pt 0pt 1pt 0pt; width:144pt;white-space:normal;">
              <div>
                <font style="letter-spacing:0.2pt;">/s/ Erik Manting</font>
              </div>
              <div style="margin-top:2.5pt; text-align:justify;">
                <div style="margin-left: 0pt; width: 144pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
              </div>
              <div style="margin-top:2pt;">
                <font style="letter-spacing:0.2pt;">Erik Manting, PhD </font>
              </div>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:20.167pt 0pt 1pt 0pt; width:204pt;">
              <div style="font-style:italic;">
                <font style="letter-spacing:0.2pt;">Director</font>
              </div>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:20.167pt 0pt 1pt 0pt; width:84pt;">
              <font style="letter-spacing:0.2pt;">December 6, 2024 </font>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td colspan="3">&#8203;</td>
          </tr>
          <tr style="line-height:12pt;height:46pt; white-space:nowrap;text-align:left;vertical-align:middle;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="padding:20.167pt 0pt 1pt 0pt; width:144pt;white-space:normal;">
              <div>
                <font style="letter-spacing:0.2pt;">/s/ Magda Marquet</font>
              </div>
              <div style="margin-top:2.5pt; text-align:justify;">
                <div style="margin-left: 0pt; width: 144pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
              </div>
              <div style="margin-top:2pt;">
                <font style="letter-spacing:0.2pt;">Magda Marquet, PhD </font>
              </div>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:20.167pt 0pt 1pt 0pt; width:204pt;">
              <div style="font-style:italic;">
                <font style="letter-spacing:0.2pt;">Director</font>
              </div>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:20.167pt 0pt 1pt 0pt; width:84pt;">
              <font style="letter-spacing:0.2pt;">December 6, 2024</font>
            </td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt 0pt 0.5pt 0pt; width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:10pt;white-space:nowrap;text-align:left;vertical-align:middle;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;">
            <td style="border-bottom:1px solid #000000; width:0pt;" colspan="7">
              <font style="letter-spacing:0.2pt;">&nbsp;&nbsp;&nbsp;</font>
            </td>
            <td style="padding:0pt;border-bottom:1px solid #000000; width:6pt;">&#8203;</td>
            <td colspan="3">&#8203;</td>
          </tr>
        </table>
      </div>
      <div style="margin-top:2.00000000000002pt;height:12pt;margin-left:69.66pt;width:456pt;">
        <div style="text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:0.2pt;">&#160;</font>
          <br >
        </div>
      </div>
      <div style="margin-top:2pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
        <div style="width:456pt;">
          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #000000; ">&#8203;</div>
        </div>
        <div style="margin-top:3pt; text-align:right; width:456pt; line-height:13pt;">
          <font style="letter-spacing:0.2pt;">II-8</font>&#8203;</div>
      </div>
      <hr >
    </div>
  </body>
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</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>2
<FILENAME>tm2430338d2_ex5-1.htm
<DESCRIPTION>EXHIBIT 5.1
<TEXT>
<HTML>
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     <TITLE></TITLE>
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<BODY STYLE="font: 10pt Times New Roman, Times, Serif">

<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>Exhibit&nbsp;5.1</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-bottom: 1pt; font-size: 10pt; width: 50%"><IMG SRC="tm2430338d2_ex5-1img001.jpg" ALT=""></TD>
    <TD STYLE="padding-bottom: 1pt; width: 50%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Goodwin Procter LLP<BR>
    100 Northern Avenue</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Boston, MA 02210</P></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">December&nbsp;6, 2024</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">TransCode Therapeutics,&nbsp;Inc.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">6 Liberty Square, #2382</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Boston, MA 02109</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; width: 4%">Re:</TD>
    <TD STYLE="font-size: 10pt; text-align: justify; width: 96%"><U>Securities Registered under Registration Statement on Form&nbsp;S-1</U></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Ladies and Gentlemen:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">We have acted as counsel to you in connection with
your filing of a Registration Statement on Form&nbsp;S-1 (as amended or supplemented, the &ldquo;Registration Statement&rdquo;), with
the Securities and Exchange Commission pursuant to the Securities Act of 1933, as amended (the &ldquo;Securities Act&rdquo;), relating
to the registration by TransCode Therapeutics,&nbsp;Inc., a Delaware corporation (the &ldquo;Company&rdquo;), of the offer and sale from
time to time by the selling stockholders listed in the Registration Statement under &ldquo;The Selling Stockholders&rdquo; (the &ldquo;Selling
Stockholders&rdquo;) of, (i)&nbsp;173,033 shares of the Company&rsquo;s common stock, par value $0.0001 per share, (&ldquo;Common Stock&rdquo;)
issued in a private placement of the Company&rsquo;s securities (the &ldquo;PIPE Shares&rdquo;), (ii)&nbsp;470,007 shares of Common Stock
(the &ldquo;PIPE PFW Shares&rdquo;) issuable upon exercise of pre-funded warrants to purchase Common Stock (the &ldquo;PIPE PFWs&rdquo;),
(iii)&nbsp;up to 4,050,951 shares of Common Stock (the &ldquo;Series&nbsp;C Common Warrant Shares&rdquo;) issuable upon exercise of warrants
to purchase Common Stock (the &ldquo;Series&nbsp;C Common Warrants&rdquo;) and (iv)&nbsp;up to 12,152,853 shares of Common Stock (the
 &ldquo;Series&nbsp;D Common Warrant Shares&rdquo; and together with the Series&nbsp;C Common Warrant Shares, the &ldquo;Common Warrant
Shares&rdquo;; the Common Warrant Shares together with the PIPE PFW Shares, the &ldquo;Warrant Shares&rdquo;) issuable upon exercise of
warrants to purchase Common Stock (the &ldquo;Series&nbsp;D Common Warrants&rdquo; and together with the Series&nbsp;C Common Warrants,
the &ldquo;Common Warrants&rdquo;; the Common Warrants together with the PIPE PFWs, the &ldquo;Warrants&rdquo;); sold to the Selling Stockholders
and certain of their affiliates pursuant to the stock purchase agreement dated as of November&nbsp;26, 2024, (the &ldquo;PIPE SPA&rdquo;)
by and among the Company and the Selling Stockholders.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">We have reviewed such documents and made such examination
of law as we have deemed appropriate to give the opinions set forth below. We have relied, without independent verification, on certificates
of public officials and, as to matters of fact material to the opinions set forth below, on certificates of officers of the Company. For
purposes of the opinions set forth in numbered paragraph 2, we have assumed that before the Warrant Shares are issued, the Company does
not issue shares of Common Stock or reduce the total number of shares of Common Stock that the Company is authorized to issue under its
certificate of incorporation such that the number of unissued shares of Common Stock authorized under the Company&rsquo;s certificate
of incorporation is less than the number of the Warrant Shares.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The opinion set forth below is limited to the Delaware
General Corporation Law.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Based on the foregoing, we are of the opinion that:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">1. The PIPE Shares have been duly authorized and
validly issued and are fully paid and non-assessable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">2. The Selling Stockholder Warrant Shares have
been duly authorized and, when issued upon exercise of the Warrants as applicable, in accordance with the terms of the Warrants, will
be validly issued, fully paid and nonassessable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Our opinions set forth above are subject to bankruptcy,
insolvency, fraudulent transfer, reorganization, moratorium and other similar laws of general application affecting the rights and remedies
of creditors and to general principles of equity.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">This opinion letter and the opinions it contains
shall be interpreted in accordance with the Core Opinion Principles as published in 74 Business Lawyer 815 (Summer 2019).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">We hereby consent to the inclusion of this opinion
as Exhibit&nbsp;5.1 to the Registration Statement and to the references to our firm under the caption &ldquo;Legal Matters&rdquo; in the
Registration Statement. In giving our consent, we do not admit that we are in the category of persons whose consent is required under
Section&nbsp;7 of the Securities Act or the rules&nbsp;and regulations thereunder.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; text-align: justify">Very truly yours,</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt">/s/ GOODWIN PROCTER LLP</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt">GOODWIN PROCTER LLP</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>3
<FILENAME>tm2430338d2_ex23-1.htm
<DESCRIPTION>EXHIBIT 23.1
<TEXT>
<HTML>
<HEAD>
     <TITLE></TITLE>
</HEAD>
<BODY STYLE="font: 10pt Times New Roman, Times, Serif">

<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="text-align: right; margin: 0"><B>Exhibit 23.1</B></P>

<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="text-transform: uppercase"><B>CONSENT
OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We hereby consent to the incorporation by reference
in the Prospectus constituting a part of this Registration Statement on Form&nbsp;S-1, of our report dated April&nbsp;1, 2024, (which
includes an explanatory paragraph relating to Transcode Therapeutics,&nbsp;Inc.&rsquo;s ability to continue as a going concern), relating
to the financial statements of Transcode Therapeutics,&nbsp;Inc. as of and for the years ended December&nbsp;31, 2023 and 2022 appearing
in the entity&rsquo;s Annual Report on Form&nbsp;10-K for the year ended December&nbsp;31, 2023. We also consent to the reference to us
under the caption &ldquo;Experts&rdquo; in the Prospectus.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">/s/ WithumSmith+Brown, PC.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">East Brunswick, New Jersey</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">December&nbsp;6, 2024</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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</DOCUMENT>
<DOCUMENT>
<TYPE>EX-FILING FEES
<SEQUENCE>4
<FILENAME>tm2430338d2_ex-filingfees.htm
<DESCRIPTION>EX-FILING FEES
<TEXT>
<HTML>
<HEAD>
     <TITLE></TITLE>
</HEAD>
<BODY STYLE="font: 10pt Times New Roman, Times, Serif">

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>Exhibit 107</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Calculation of Filing Fee Tables</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><U>S-1<BR>
</U></B>(Form Type)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><U>TransCode Therapeutics, Inc.<BR>
</U></B>(Exact Name of Registrant as Specified in its Charter)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><U>Table 1: Newly Registered and Carry Forward
Securities</U>&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR>
    <TD STYLE="white-space: nowrap; padding-bottom: 1pt; vertical-align: top; padding-left: 9.25pt">&nbsp;</TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom; padding-bottom: 1pt; text-align: center">&nbsp;</TD>
    <TD STYLE="white-space: nowrap; border-bottom: Black 1pt solid; vertical-align: bottom; text-align: center"><B>Security<BR>
Type</B></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom; padding-bottom: 1pt; text-align: center">&nbsp;</TD>
    <TD STYLE="white-space: nowrap; border-bottom: Black 1pt solid; vertical-align: bottom; text-align: center"><B>Security<BR>
Class Title</B></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom; padding-bottom: 1pt; text-align: center">&nbsp;</TD>
    <TD STYLE="white-space: nowrap; border-bottom: Black 1pt solid; vertical-align: bottom; text-align: center"><B>Fee<BR>
Calculation<BR>
or Carry<BR>
Forward<BR>
Rule</B></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom; padding-bottom: 1pt; text-align: center">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="white-space: nowrap; border-bottom: Black 1pt solid; vertical-align: bottom; text-align: center"><B>Amount<BR>
Registered</B></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom; padding-bottom: 1pt; text-align: center">&nbsp;</TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom; padding-bottom: 1pt; text-align: center">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="white-space: nowrap; border-bottom: Black 1pt solid; vertical-align: bottom; text-align: center"><B>Proposed<BR>
Maximum<BR>
Offering<BR>
Price Per<BR>
Share</B></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom; padding-bottom: 1pt; text-align: center">&nbsp;</TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom; padding-bottom: 1pt; text-align: center">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="white-space: nowrap; border-bottom: Black 1pt solid; vertical-align: bottom; text-align: center"><B>Maximum<BR>
Aggregate<BR>
Offering<BR>
Price<FONT STYLE="font-size: 10pt"><SUP>(1)</SUP></FONT></B></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom; padding-bottom: 1pt; text-align: center">&nbsp;</TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom; padding-bottom: 1pt; text-align: center">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="white-space: nowrap; border-bottom: Black 1pt solid; vertical-align: bottom; text-align: center"><B>Fee Rate</B></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom; padding-bottom: 1pt; text-align: center">&nbsp;</TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom; padding-bottom: 1pt; text-align: center">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="white-space: nowrap; border-bottom: Black 1pt solid; vertical-align: bottom; text-align: center"><B>Amount of<BR>
Registration<BR>
Fee</B></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom; padding-bottom: 1pt; text-align: center">&nbsp;</TD></TR>
  <TR STYLE="background-color: rgb(204,238,255)">
    <TD STYLE="vertical-align: top; padding-left: 9.25pt; text-indent: -9pt">Fees to be Paid</TD>
    <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
    <TD STYLE="vertical-align: top; text-align: center; width: 7%">Equity</TD>
    <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center; width: 20%">Common stock, $0.0001 par value per share</TD>
    <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center; width: 8%">457(g)</TD>
    <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right; width: 7%">&mdash;</TD>
    <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right; width: 7%">&mdash;</TD>
    <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; width: 1%">$</TD>
    <TD STYLE="vertical-align: bottom; text-align: right; width: 8%">2,152,704</TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom; padding-bottom: 5pt; width: 1%">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right; width: 8%">0.00015310</TD>
    <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; width: 1%">$</TD>
    <TD STYLE="vertical-align: bottom; text-align: right; width: 8%">329.58</TD>
    <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD></TR>
  <TR STYLE="background-color: White">
    <TD STYLE="vertical-align: top; padding-left: 9.25pt; text-indent: -9pt">Fees to be Paid</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top; text-align: center">Equity</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">Common stock underlying the Pre-Funded Warrants</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">457(g)</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">&mdash;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">&mdash;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">5,847,357</TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom; padding-bottom: 5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">$</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">0.00015310</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">$</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">895.23</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
  <TR STYLE="background-color: rgb(204,238,255)">
    <TD STYLE="vertical-align: top; padding-left: 9.25pt; text-indent: -9pt">Fees to be Paid</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top; text-align: center">Equity</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">Common stock underlying the Series C Warrants<FONT STYLE="font-size: 10pt"><SUP>(2)</SUP></FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">457(g)</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">&mdash;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">&mdash;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">$</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">10,079,576</TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom; padding-bottom: 5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">$</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">0.00015310</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">$</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">1,543.18</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
  <TR STYLE="background-color: White">
    <TD STYLE="vertical-align: top; padding-left: 9.25pt; text-indent: -9pt">Fees to be Paid</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top; text-align: center">Equity</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">Common stock underlying the Series D Warrants<FONT STYLE="font-size: 10pt"><SUP>(3)</SUP></FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">457(g)</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">&mdash;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">&mdash;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">$</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">30,238,729</TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom; padding-bottom: 5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">$</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">0.00015310</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">$</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">4,629.55</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
  <TR STYLE="background-color: rgb(204,238,255)">
    <TD STYLE="vertical-align: top; padding-left: 9.25pt; text-indent: -9pt">Fees Previously Paid</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&mdash;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&mdash;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&mdash;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">&mdash;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">&mdash;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">&mdash;</TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom; padding-bottom: 5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">&mdash;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">$</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">&mdash;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
  <TR STYLE="background-color: White">
    <TD STYLE="vertical-align: top; padding-left: 9.25pt; text-indent: -9pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">&nbsp;</TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom; padding-bottom: 5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
  <TR STYLE="background-color: rgb(204,238,255)">
    <TD STYLE="vertical-align: top; padding-left: 9.25pt; text-indent: -9pt">Carry Forward Securities</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&mdash;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&mdash;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&mdash;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">&mdash;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">&mdash;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">&mdash;</TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom; padding-bottom: 5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">&mdash;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">&mdash;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD COLSPAN="7" STYLE="padding-bottom: 1pt; text-align: center"><B>Total Offering Amounts</B></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt; text-align: right">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt; text-align: right">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD>$</TD>
    <TD STYLE="text-align: right">48,318,366</TD>
    <TD STYLE="white-space: nowrap; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid">$</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: right">7,397.54</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD COLSPAN="7" STYLE="padding-bottom: 1pt; text-align: center"><B>Total Fees Previously Paid</B></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt; text-align: right">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt; text-align: right">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="white-space: nowrap; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: right">&mdash;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD COLSPAN="7" STYLE="padding-bottom: 1pt; text-align: center"><B>Total Fee Offset</B></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt; text-align: right">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt; text-align: right">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="white-space: nowrap; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: right">&mdash;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD COLSPAN="7" STYLE="padding-bottom: 2.5pt; text-align: center"><B>Net Fee Due</B></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 2.5pt; text-align: right">&nbsp;</TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 2.5pt; text-align: right">&nbsp;</TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="white-space: nowrap; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double">$</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; text-align: right">7,397.54</TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <TR STYLE="vertical-align: top">
    <TD>(1)</TD>
    <TD STYLE="text-align: justify">Pursuant to Rule 416, the securities being registered hereunder include such indeterminate number of additional securities as may be issued after the date hereof as a result of stock splits, stock dividends or similar transactions.</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>(2)</TD>
    <TD STYLE="text-align: justify">The maximum aggregate offering price of the Series C Warrants were calculated using the Floor Price per warrant.</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>(3)</TD>
    <TD STYLE="text-align: justify">The maximum aggregate offering price of the Series D Warrants were calculated using the Floor Price per warrant. </TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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L"                                                     !__]D!

end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
