<SEC-DOCUMENT>0001104659-25-029875.txt : 20250331
<SEC-HEADER>0001104659-25-029875.hdr.sgml : 20250331
<ACCEPTANCE-DATETIME>20250331161544
ACCESSION NUMBER:		0001104659-25-029875
CONFORMED SUBMISSION TYPE:	NT 10-K
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20241231
FILED AS OF DATE:		20250331
DATE AS OF CHANGE:		20250331
EFFECTIVENESS DATE:		20250331

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Transcode Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001829635
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				811065054
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		NT 10-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-40363
		FILM NUMBER:		25793458

	BUSINESS ADDRESS:	
		STREET 1:		6 LIBERTY SQUARE
		STREET 2:		#2382
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02109
		BUSINESS PHONE:		857-301-6857

	MAIL ADDRESS:	
		STREET 1:		6 LIBERTY SQUARE
		STREET 2:		#2382
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02109
</SEC-HEADER>
<DOCUMENT>
<TYPE>NT 10-K
<SEQUENCE>1
<FILENAME>tm2510924d1_nt10k.htm
<DESCRIPTION>NT 10-K
<TEXT>
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<P STYLE="margin: 0">&nbsp;</P>

<!-- Field: Rule-Page --><DIV STYLE="margin-top: 0; margin-bottom: 0; width: 100%"><DIV STYLE="font-size: 1pt; border-top: Black 2pt solid; border-bottom: Black 1pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->

<P STYLE="margin: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNITED STATES</B></P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Washington, D.C. 20549</B></P>

<P STYLE="border-bottom: Black 1pt solid; text-align: center; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>

<P STYLE="text-align: center; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>FORM&nbsp;12b-25</B></P>

<P STYLE="border-bottom: Black 1pt solid; text-align: center; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>NOTIFICATION OF LATE FILING</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; font-size: 10pt; text-align: right"><I>(Check one):&emsp;</I></TD>
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-family: Times New Roman, Times, Serif"><FONT STYLE="font-family: Wingdings">&#120;</FONT></FONT>&ensp;Form&nbsp;10-K&emsp; <FONT STYLE="font-family: Wingdings">&#168;</FONT>&ensp;Form&nbsp;20-F&emsp; <FONT STYLE="font-family: Wingdings">&#168;</FONT>&ensp;Form&nbsp;11-K <FONT STYLE="font-family: Times New Roman, Times, Serif"><BR>
<FONT STYLE="font-family: Wingdings">&#168;</FONT></FONT>&ensp;Form&nbsp;10-Q&emsp; <FONT STYLE="font-family: Times New Roman, Times, Serif"><FONT STYLE="font-family: Wingdings">&#168;</FONT></FONT>&ensp;Form&nbsp;10-D&emsp; <FONT STYLE="font-family: Times New Roman, Times, Serif"><FONT STYLE="font-family: Wingdings">&#168;</FONT></FONT>&ensp;Form&nbsp;N-CEN &emsp;<FONT STYLE="font-family: Times New Roman, Times, Serif"><FONT STYLE="font-family: Wingdings">&#168;</FONT></FONT>&ensp;Form&nbsp;N-CSR</TD></TR>
  <TR>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font-size: 10pt">For Period Ended: December&nbsp;31, 2024</TD></TR>
  <TR>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font-size: 10pt"><FONT STYLE="font-family: Wingdings">&#168;</FONT>&ensp;Transition Report on Form&nbsp;10-K</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font-size: 10pt"><FONT STYLE="font-family: Wingdings">&#168;</FONT>&ensp;Transition Report on Form&nbsp;20-F</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font-size: 10pt"><FONT STYLE="font-family: Wingdings">&#168;</FONT>&ensp;Transition Report on Form&nbsp;11-K</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font-size: 10pt"><FONT STYLE="font-family: Wingdings">&#168;</FONT>&ensp;Transition Report on Form&nbsp;10-Q</TD></TR>
  <TR>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font-size: 10pt">For the Transition Period Ended:&#8239;&#8239;</TD></TR>
  </TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR>
    <TD STYLE="border-top: black 1pt solid; text-align: center; border-right: black 1pt solid; border-left: black 1pt solid; padding-left: 8.4pt; font-size: 10pt"><B>Nothing
    in this form shall be construed to imply that the Commission has verified any information</B></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; padding-right: 2.4pt; padding-left: 8.4pt; font-size: 10pt; text-align: center"><B>contained
    herein.</B></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">If the notification relates to a portion of the filing checked above,
identify the Item(s)&nbsp;to which the notification relates:</P>

<P STYLE="border-bottom: Black 1pt solid; text-align: center; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>PART&nbsp;I &mdash; REGISTRANT INFORMATION</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>TransCode Therapeutics,&nbsp;Inc.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Full Name of Registrant</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Not applicable</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Former Name if Applicable</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>6 Liberty Square, #2382</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Address of Principal Executive Office (Street
and Number)</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Boston, Massachusetts 02109</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>City, State and Zip Code</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR>
    <TD STYLE="vertical-align: top; font-size: 10pt; width: 9%">SEC 1344<BR>
 (01-19)</TD>
    <TD STYLE="text-align: justify; vertical-align: top; font-size: 10pt; width: 91%">Potential persons who are to respond to the collection of information contained in this Form&nbsp;are not required to respond unless the Form&nbsp;displays a currently valid OMB control number.</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>PART&nbsp;II &mdash; RULES 12b-25(b)&nbsp;AND
(c)</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">If the subject report could not be filed without unreasonable effort
or expense and the registrant seeks relief pursuant to Rule&nbsp;12b-25(b), the following should be completed. (Check box if appropriate)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR>
    <TD ROWSPAN="3" STYLE="padding-bottom: 3pt; text-align: center; border-right: black 1pt solid; width: 5%; vertical-align: middle"><FONT STYLE="font-family: Wingdings">&#120;</FONT></TD>
    <TD STYLE="text-align: center; padding-bottom: 3pt; vertical-align: top; width: 5%">(a)</TD>
    <TD STYLE="text-align: justify; padding-bottom: 3pt; vertical-align: top; width: 90%">The reason described in reasonable detail in Part&nbsp;III of this Form&nbsp;could not be eliminated without unreasonable effort or expense;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="vertical-align: top; text-align: center; padding-bottom: 3pt">(b)</TD>
    <TD STYLE="text-align: justify; padding-bottom: 3pt">The subject annual report, semi-annual report, transition report on Form&nbsp;10-K, Form&nbsp;20-F, Form&nbsp;11-K, Form&nbsp;N-CEN or Form&nbsp;N-CSR, or portion thereof, will be filed on or before the fifteenth calendar day following the prescribed due date; or the subject quarterly report or transition report on Form&nbsp;10-Q or subject distribution report on Form&nbsp;10-D, or portion thereof, will be filed on or before the fifth calendar day following the prescribed due date; and</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="vertical-align: top; text-align: center">(c)</TD>
    <TD STYLE="text-align: justify">The accountant&rsquo;s statement or other exhibit required by Rule&nbsp;12b-25(c)&nbsp;has been attached if applicable.</TD></TR>
  </TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>PART&nbsp;III &mdash; NARRATIVE</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">State below in reasonable detail why Forms 10-K, 20-F, 11-K, 10-Q,
10-D, N-CEN, N-CSR, or the transition report or portion thereof, could not be filed within the prescribed time period.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">TransCode Therapeutics,&nbsp;Inc, (the &ldquo;Company&rdquo;) has determined
that it will not be able to file its Annual Report on Form&nbsp;10-K for the fiscal year ended December&nbsp;31, 2024 (the &ldquo;2024
Form&nbsp;10-K&rdquo;) within the prescribed time period for such filing without unreasonable effort or expense. On March&nbsp;23, 2025,
the Company entered into a Placement Agency Agreement (the &ldquo;Agreement&rdquo;) with ThinkEquity LLC (the &ldquo;Placement Agent&rdquo;),
pursuant to which the Company agreed to issue and sell, directly to various investors, in a registered direct offering (the &ldquo;Registered
Direct Offering&rdquo;), an aggregate of 10,250,000 shares (the &ldquo;Shares&rdquo;) of the Company&rsquo;s common stock, par value $0.0001
per share, (the &ldquo;Common Stock&rdquo;) and 10,250,000 Common Warrants (the &ldquo;Common Warrants&rdquo;) to purchase 10,250,000
shares of Common Stock, at an aggregate offering price of $0.98 per share of Common Stock and accompanying Common Warrant. The Registered
Direct Offering closed on March&nbsp;25, 2025. The Company will need to make disclosures related to the Registered Direct Offering in
the 2024 Form&nbsp;10-K. The Company requires additional time to complete the procedures relating to its year-end reporting process, including
disclosures related to the recent Registered Direct Offering for inclusion in the 2024 Form&nbsp;10-K. The Company expects to file the
2024 Form&nbsp;10-K within the extension period provided under Rule&nbsp;12b-25 under the Securities Exchange Act of 1934, as amended.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>PART&nbsp;IV &mdash; OTHER INFORMATION</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR>
    <TD STYLE="vertical-align: top; font-size: 10pt">(1)</TD>
    <TD COLSPAN="5" STYLE="text-align: justify; vertical-align: bottom; font-size: 10pt">Name and telephone number of person to contact in regard to this notification</TD></TR>
  <TR>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="text-align: center; vertical-align: top; width: 3%">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; vertical-align: bottom; font-size: 10pt; text-align: center; width: 43%">Thomas A.&nbsp; Fitzgerald</TD>
    <TD STYLE="text-align: center; vertical-align: bottom; font-size: 10pt; width: 1%">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; vertical-align: bottom; font-size: 10pt; text-align: center; width: 19%">(857)</TD>
    <TD STYLE="text-align: center; vertical-align: bottom; font-size: 10pt; width: 1%">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; vertical-align: bottom; font-size: 10pt; text-align: center; width: 33%">837-3099</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>(Name)</B></FONT></TD>
    <TD STYLE="vertical-align: bottom; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>(Area Code)</B></FONT></TD>
    <TD STYLE="vertical-align: bottom; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>(Telephone Number)</B></FONT></TD></TR>
  <TR>
    <TD>&nbsp;</TD>
    <TD COLSPAN="5">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; font-size: 10pt">(2)</TD>
    <TD COLSPAN="5" STYLE="text-align: justify; vertical-align: bottom; font-size: 10pt">Have all other periodic reports required under Section&nbsp;13 or 15(d)&nbsp;of the Securities Exchange Act of 1934 or Section&nbsp;30 of the Investment Company Act of 1940 during the preceding 12 months or for such shorter period that the registrant was required to file such report(s)&nbsp;been filed? If answer is no, identify report(s). &emsp;<FONT STYLE="font-family: Times New Roman, Times, Serif"><FONT STYLE="font-family: Wingdings">&#120;</FONT></FONT>&ensp;Yes&emsp;<FONT STYLE="font-family: Times New Roman, Times, Serif"><FONT STYLE="font-family: Wingdings">&#168;</FONT></FONT>&ensp;No</TD></TR>
  <TR>
    <TD>&nbsp;</TD>
    <TD COLSPAN="5">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; font-size: 10pt">(3)</TD>
    <TD COLSPAN="5" STYLE="text-align: justify; vertical-align: bottom; font-size: 10pt">Is it anticipated that any significant change in results of operations from the corresponding period for the last fiscal year will be reflected by the earnings statements to be included in the subject report or portion thereof? &emsp;&ensp;<FONT STYLE="font-family: Times New Roman, Times, Serif"><FONT STYLE="font-family: Wingdings">&#120;</FONT> </FONT>Yes&emsp;<FONT STYLE="font-family: Times New Roman, Times, Serif"><FONT STYLE="font-family: Wingdings">&#168;</FONT></FONT>&ensp;No</TD></TR>
  <TR>
    <TD>&nbsp;</TD>
    <TD COLSPAN="5">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="vertical-align: bottom"><P STYLE="text-align: justify; margin-top: 0; margin-bottom: 0">If so, attach an explanation of the anticipated change, both narratively and quantitatively, and, if appropriate, state the reasons why a reasonable estimate of the results cannot be made.</P>
                                                   <P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>
                                                   <P STYLE="text-align: justify; margin-top: 0; margin-bottom: 0">The Registered Direct Offering along with other warrants issued by the Company during the year ended December&nbsp;31, 2024 had a significant impact on the Company&rsquo;s financial performance and capitalization, which could result in a significant change in results of operations from the corresponding period for the last fiscal year. Due to the recency of the Registered Direct Offering, additional time (within the extension period) is needed to complete the analysis of and assess the proper accounting treatment for,
the securities issued in the aforementioned financings.</P></TD></TR>
  </TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Forward-Looking Statements</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">This document contains forward-looking statements
within the meaning of the United States Private Securities Litigation Reform Act of 1995 (collectively, &ldquo;forward-looking statements&rdquo;).
Forward-looking statements may include, but are not limited to, statements regarding the Company or its management team&rsquo;s expectations,
hopes, beliefs, intentions or strategies regarding the future, including statements about the timing of the filing of the Annual Report
on Form&nbsp;10-K and statements about the Company&rsquo;s preliminary financial results for the fiscal year ended December&nbsp;31, 2024.
Forward-looking statements are typically identified by words such as &ldquo;plan,&rdquo; &ldquo;believe,&rdquo; &ldquo;expect,&rdquo;
&ldquo;anticipate,&rdquo; &ldquo;intend,&rdquo; &ldquo;outlook,&rdquo; &ldquo;estimate,&rdquo; &ldquo;forecast,&rdquo; &ldquo;project,&rdquo;
&ldquo;continue,&rdquo; &ldquo;could,&rdquo; &ldquo;may,&rdquo; &ldquo;might,&rdquo; &ldquo;possible,&rdquo; &ldquo;potential,&rdquo;
&ldquo;predict,&rdquo; &ldquo;should,&rdquo; &ldquo;would&rdquo; and other similar words and expressions, but the absence of these words
does not mean that a statement is not forward-looking.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The forward-looking statements are based on the
current expectations of the management of the Company and are inherently subject to uncertainties and changes in circumstances and their
potential effects and speak only as of the date of such statement. There can be no assurance that future developments will be those that
have been anticipated. Forward-looking statements reflect material expectations and assumptions, including, without limitation, expectations
and assumptions relating to the Company&rsquo;s auditors being able to complete their audit of the Company&rsquo;s annual financial statements
in a timely manner. Such expectations and assumptions are inherently subject to uncertainties and contingencies regarding future events
and, as such, are subject to change. Forward-looking statements involve a number of risks, uncertainties or other factors that may cause
actual results or performance to be materially different from those expressed or implied by these forward-looking statements. These risks
and uncertainties include, but are not limited to, those discussed and identified in public filings made by the Company with the Securities
and Exchange Commission (the &ldquo;SEC&rdquo;) and the Company&rsquo;s auditors being unable to complete their review of the Company&rsquo;s
annual financial statements in a timely manner and the Company consequently not filing the Annual Report on Form&nbsp;10-K within the
time period prescribed in Rule&nbsp;12b-25 promulgated under the Securities Exchange Act of 1934.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Any financial results discussed in this document
are preliminary and represent the most current information available to the Company&rsquo;s management as of March&nbsp;31, 2025, as financial
closing procedures for the fiscal year ended December&nbsp;31, 2024, are not yet complete. These estimates are not a comprehensive statement
of the Company&rsquo;s financial results for the fiscal year ended December&nbsp;31, 2024, and actual results may differ materially from
these estimates as a result of completion of year-end accounting procedures and adjustments, including the execution of the Company&rsquo;s
internal control over financial reporting, completion of the preparation and audit of the Company&rsquo;s financial statements and the
subsequent occurrence or identification of events prior to the filing of the Company&rsquo;s audited financial statements for the fiscal
year ended December&nbsp;31, 2024, in its Annual Report on Form&nbsp;10-K. In addition, any such statements regarding the Company&rsquo;s
financial performance are not necessarily indicative of the Company&rsquo;s financial performance that may be expected for the fiscal
quarter ending December&nbsp;31, 2024, or for any future fiscal period.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Should one or more of these risks or uncertainties
materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those described herein. This list
is not exhaustive of the factors that may affect any of the Company&rsquo;s forward-looking statements. Forward-looking statements are
statements about the future and are inherently uncertain. Actual achievements of the Company or other future events or conditions may
differ materially from those reflected in the forward-looking statements due to a variety of risks, uncertainties, and other factors,
including without limitation those discussed under Part&nbsp;I,&nbsp;Item 1A. &ldquo;Risk Factors&rdquo; contained in the Company&rsquo;s
most recent Annual Report on Form&nbsp;10-K, and Part&nbsp;II,&nbsp;Item 1A. &ldquo;Risk Factors&rdquo; contained in the Company&rsquo;s
subsequent Quarterly Reports on Form&nbsp;10-Q, as well as any amendments thereto.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The Company&rsquo;s forward-looking statements
contained in this document are based on the beliefs, expectations, and opinions of management as of the date of this document. The Company
does not assume any obligation to update forward-looking statements if circumstances or management&rsquo;s beliefs, expectations, or opinions
should change, except as required by law. For the reasons set forth above, investors should not attribute undue certainty to, or place
undue reliance on, forward-looking statements.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><U>TransCode Therapeutics,&nbsp;Inc.</U></P>

<P STYLE="text-align: center; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">(Name of Registrant as Specified in Charter)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">has caused this notification to be signed on its behalf by the undersigned
hereunto duly authorized.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR>
    <TD STYLE="vertical-align: top; font-size: 10pt; width: 50%">Date: March&nbsp;31, 2025</TD>
    <TD STYLE="vertical-align: top; font-size: 10pt; width: 3%">By:</TD>
    <TD STYLE="border-bottom: Black 1pt solid; vertical-align: top; width: 47%">/s/ Thomas A. Fitzgerald</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: top; font-size: 10pt">Thomas A. Fitzgerald</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: top; font-size: 10pt">Interim Chief Executive Officer and Chief Financial Officer</TD></TR>
  </TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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