<SEC-DOCUMENT>0001140361-19-017862.txt : 20191002
<SEC-HEADER>0001140361-19-017862.hdr.sgml : 20191002
<ACCEPTANCE-DATETIME>20191002181037
ACCESSION NUMBER:		0001140361-19-017862
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20191002
FILED AS OF DATE:		20191002
DATE AS OF CHANGE:		20191002

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			ROCKLAGE SCOTT M
		CENTRAL INDEX KEY:			0001219014

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-39069
		FILM NUMBER:		191133630

	MAIL ADDRESS:	
		STREET 1:		179 SANDY POND ROAD
		CITY:			LINCOLN
		STATE:			MA
		ZIP:			01773

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Aprea Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001781983
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		535 BOYLSTON STREET
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116
		BUSINESS PHONE:		6095104718

	MAIL ADDRESS:	
		STREET 1:		535 BOYLSTON STREET
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>form3.xml
<DESCRIPTION>FORM 3
<TEXT>
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<ownershipDocument>

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    <documentType>3</documentType>

    <periodOfReport>2019-10-02</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001781983</issuerCik>
        <issuerName>Aprea Therapeutics, Inc.</issuerName>
        <issuerTradingSymbol>APRE</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001219014</rptOwnerCik>
            <rptOwnerName>ROCKLAGE SCOTT M</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>535 BOYLSTON STREET</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>BOSTON</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02116</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>12163</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                    <footnoteId id="F2"/>
                    <footnoteId id="F4"/>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnotes</value>
                    <footnoteId id="F2"/>
                    <footnoteId id="F4"/>
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        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
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                    <value>507</value>
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            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                    <footnoteId id="F3"/>
                    <footnoteId id="F4"/>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnotes</value>
                    <footnoteId id="F3"/>
                    <footnoteId id="F4"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
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    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Series B Convertible Preferred Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F1"/>
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            <exerciseDate>
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            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
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                <underlyingSecurityShares>
                    <value>1913910</value>
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            </underlyingSecurity>
            <ownershipNature>
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                    <value>I</value>
                    <footnoteId id="F2"/>
                    <footnoteId id="F4"/>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnotes</value>
                    <footnoteId id="F2"/>
                    <footnoteId id="F4"/>
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        <derivativeHolding>
            <securityTitle>
                <value>Series B Convertible Preferred Stock</value>
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            <underlyingSecurity>
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                    <value>Common Stock</value>
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                <underlyingSecurityShares>
                    <value>79746</value>
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            <ownershipNature>
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                    <value>I</value>
                    <footnoteId id="F3"/>
                    <footnoteId id="F4"/>
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                <natureOfOwnership>
                    <value>See footnotes</value>
                    <footnoteId id="F3"/>
                    <footnoteId id="F4"/>
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        <derivativeHolding>
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                <value>Series C Convertible Preferred Stock</value>
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            <conversionOrExercisePrice>
                <footnoteId id="F1"/>
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            <exerciseDate>
                <footnoteId id="F1"/>
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            <expirationDate>
                <footnoteId id="F1"/>
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            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>492475</value>
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            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                    <footnoteId id="F2"/>
                    <footnoteId id="F4"/>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnotes</value>
                    <footnoteId id="F2"/>
                    <footnoteId id="F4"/>
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            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Series C Convertible Preferred Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F1"/>
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            <exerciseDate>
                <footnoteId id="F1"/>
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            <expirationDate>
                <footnoteId id="F1"/>
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            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
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                <underlyingSecurityShares>
                    <value>20519</value>
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            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                    <footnoteId id="F3"/>
                    <footnoteId id="F4"/>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnotes</value>
                    <footnoteId id="F3"/>
                    <footnoteId id="F4"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
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    <footnotes>
        <footnote id="F1">These shares of Series B Convertible Preferred Stock and Series C Convertible Preferred Stock (collectively, &quot;Preferred Stock&quot;) will automatically be converted into shares of the Issuer's Common Stock (&quot;Common Stock&quot;), on a 1-for-1 basis, immediately prior to the completion of the Issuer's initial public offering.  The Preferred Stock has no expiration date.</footnote>
        <footnote id="F2">Shares are held directly by 5AM Ventures IV, L.P.</footnote>
        <footnote id="F3">Shares are held directly by 5AM Co-Investors IV, L.P.</footnote>
        <footnote id="F4">5AM Partners IV, LLC is the sole general partner of each of 5AM Ventures IV, L.P. and 5AM Co-Investors IV, L.P. (collectively, the &quot;5AM Funds&quot;).  The reporting person is a managing member of 5AM Partners IV, LLC and may be deemed to have shared voting and investment power over the shares beneficially owned by the 5AM Funds.  The reporting person disclaims beneficial ownership of the shares of Common Stock and Preferred Stock held directly by the 5AM Funds, except to the extent of his pecuniary interest therein.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Scott M. Coiante, attorney-in-fact</signatureName>
        <signatureDate>2019-10-02</signatureDate>
    </ownerSignature>
</ownershipDocument>
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<TYPE>EX-24
<SEQUENCE>2
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<DESCRIPTION>EXHIBIT 24
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    <div style="text-align: right;"><font style="font-weight: bold;">Exhibit 24</font><br>
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      <div style="text-align: center; font-weight: bold;">POWER OF ATTORNEY</div>
      <div>&#160;</div>
      <div style="text-indent: 36pt;">Know all by these presents, that the undersigned hereby makes, constitutes and appoints each of Christian S. Schade and Scott M. Coiante, or either of
        them acting individually, and with full power of substitution, the undersigned's true and lawful attorney-in-fact to:</div>
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                <td style="width: 31.5pt; vertical-align: top; align: right; color: #1F1F1F;">(1)</td>
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                  <div style="color: #1F1F1F;">prepare, execute in the undersigned's name and on the undersigned's behalf, and submit to the U.S. Securities and Exchange Commission (the "SEC") a Form ID,
                    including amendments thereto, and any other documents necessary or appropriate to obtain codes and passwords enabling the undersigned to make electronic filings with the SEC of reports required by Section 16(a) of the Securities
                    Exchange Act of 1934 or any rule or regulation of the SEC;</div>
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      <div>&#160;</div>
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                <td style="width: 31.5pt; vertical-align: top; align: right; color: #1F1F1F;">(2)</td>
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                  <div><font style="color: #1F1F1F;">execute for and on behalf of the undersigned, in the undersigned's capacity as an officer and/or
                      director of </font>Aprea Therapeutics, Inc. <font style="color: #1F1F1F;">a Delaware corporation (the "Company"), Forms 3, 4, and 5, including amendments thereto, in accordance with
                      Section 16(a) of the Securities Exchange Act of 1934 and the rules and regulations thereunder;</font></div>
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      <div>&#160;</div>
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                <td style="width: 31.5pt; vertical-align: top; align: right;">(3)</td>
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                  <div style="color: #1F1F1F;">do and perform any and all acts for and on behalf of the undersigned which may be necessary or desirable to complete and execute any such Form 3, 4, or 5,
                    complete and execute any amendment or amendments thereto, and timely file such form with the SEC and any stock exchange or similar authority; and</div>
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      <div>&#160;</div>
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                <td style="width: 31.5pt; vertical-align: top; align: right;">(4)</td>
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                  <div style="color: #1F1F1F;">take any other action of any type whatsoever in connection with the foregoing which, in the opinion of such attorney-in-fact, may be of benefit to, in the best
                    interest of, or legally required by, the undersigned, it being understood that the documents executed by such attorney-in-fact on behalf of the undersigned pursuant to this Power of Attorney shall be in such form and shall contain such
                    terms and conditions as such attorney-in-fact may approve in such attorney-in-fact's discretion.</div>
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      <div>&#160;</div>
      <div style="text-indent: 36pt; color: #1F1F1F;">The undersigned hereby grants to each such attorney-in-fact full power and authority to do and perform any and every act and thing
        whatsoever requisite, necessary, or proper to be done in the exercise of any of the rights and powers herein granted, as fully to all intents and purposes as the undersigned might or could do if personally present, with full power of substitution
        or revocation, hereby ratifying and confirming all that such attorney-in-fact, or such attorney-in-fact's substitute or substitutes, shall lawfully do or cause to be done by virtue of this power of attorney and the rights and powers herein granted.
        The undersigned acknowledges that the foregoing attorneys-in-fact, in serving in such capacity at the request of the undersigned, are not assuming, nor is the Company assuming, any of the undersigned's responsibilities to comply with Section 16 of
        the Securities Exchange Act of 1934.</div>
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      <div style="text-indent: 36pt;"><font style="color: #1F1F1F;">This Power of Attorney shall remain in full force and effect until the
          undersigned is no longer required to file Forms 3, 4, and 5 with respect to the undersigned's holdings of and transactions in securities issued by the Company, unless earlier (a) revoked by the undersigned </font><font style="color: #3F3F3F;">i</font><font style="color: #1F1F1F;">n a signed writing delivered to the foregoing attorneys-in-fact or (b) superseded by a new power of attorney
          regarding the purposes outlined herein at a later date.</font></div>
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      <div style="text-indent: 36pt;">IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to be executed as of this __<u>19</u>___ <font style="color: rgb(31, 31, 31);">day of </font>__<u>September</u>_________,<font style="color: rgb(31, 31, 31);"> 2019.</font></div>
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              <div style="color: #1F1F1F;">/s/ Scott M. Rocklage</div>
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              <div style="color: #1F1F1F;">Scott M. Rocklage</div>
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