<SEC-DOCUMENT>0001123292-19-001194.txt : 20191002
<SEC-HEADER>0001123292-19-001194.hdr.sgml : 20191002
<ACCEPTANCE-DATETIME>20191002205008
ACCESSION NUMBER:		0001123292-19-001194
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		3
CONFORMED PERIOD OF REPORT:	20191002
FILED AS OF DATE:		20191002
DATE AS OF CHANGE:		20191002

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			KDev Investments AB
		CENTRAL INDEX KEY:			0001789888
		STATE OF INCORPORATION:			V7
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-39069
		FILM NUMBER:		191134070

	BUSINESS ADDRESS:	
		STREET 1:		TOMTEBODAVAGEN 23A
		CITY:			SOLNA
		STATE:			V7
		ZIP:			SE 171 65
		BUSINESS PHONE:		08-524 860 70

	MAIL ADDRESS:	
		STREET 1:		TOMTEBODAVAGEN 23A
		CITY:			SOLNA
		STATE:			V7
		ZIP:			SE 171 65

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Karolinska Development AB
		CENTRAL INDEX KEY:			0001789932
		STATE OF INCORPORATION:			V7
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-39069
		FILM NUMBER:		191134071

	BUSINESS ADDRESS:	
		STREET 1:		TOMTEBODAVAGEN 23A
		CITY:			SOLNA
		STATE:			V7
		ZIP:			SE 171 65
		BUSINESS PHONE:		08-524 860 70

	MAIL ADDRESS:	
		STREET 1:		TOMTEBODAVAGEN 23A
		CITY:			SOLNA
		STATE:			V7
		ZIP:			SE 171 65

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			KCIF Co-Investment Fund KB
		CENTRAL INDEX KEY:			0001789966
		STATE OF INCORPORATION:			V7
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-39069
		FILM NUMBER:		191134072

	BUSINESS ADDRESS:	
		STREET 1:		TOMTEBODAVAGEN 23A
		CITY:			SOLNA
		STATE:			V7
		ZIP:			SE 171 65
		BUSINESS PHONE:		08-524 860 70

	MAIL ADDRESS:	
		STREET 1:		TOMTEBODAVAGEN 23A
		CITY:			SOLNA
		STATE:			V7
		ZIP:			SE 171 65

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Aprea Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001781983
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		535 BOYLSTON STREET
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116
		BUSINESS PHONE:		6095104718

	MAIL ADDRESS:	
		STREET 1:		535 BOYLSTON STREET
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
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<DESCRIPTION>PRIMARY DOCUMENT
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<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2019-10-02</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001781983</issuerCik>
        <issuerName>Aprea Therapeutics, Inc.</issuerName>
        <issuerTradingSymbol>APRE</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001789888</rptOwnerCik>
            <rptOwnerName>KDev Investments AB</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>TOMTEBODAVAGEN 23A</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>SOLNA</rptOwnerCity>
            <rptOwnerState>V7</rptOwnerState>
            <rptOwnerZipCode>SE-17165</rptOwnerZipCode>
            <rptOwnerStateDescription>SWEDEN</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001789932</rptOwnerCik>
            <rptOwnerName>Karolinska Development AB</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>TOMTEBODAVAGEN 23A</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>SOLNA</rptOwnerCity>
            <rptOwnerState>V7</rptOwnerState>
            <rptOwnerZipCode>SE-17165</rptOwnerZipCode>
            <rptOwnerStateDescription>SWEDEN</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
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            <isOther>0</isOther>
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    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001789966</rptOwnerCik>
            <rptOwnerName>KCIF Co-Investment Fund KB</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>TOMTEBODAVAGEN 23A</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>SOLNA</rptOwnerCity>
            <rptOwnerState>V7</rptOwnerState>
            <rptOwnerZipCode>SE-17165</rptOwnerZipCode>
            <rptOwnerStateDescription>SWEDEN</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
                <footnoteId id="F1"/>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>844278</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Series A Convertible Preferred Stock</value>
                <footnoteId id="F1"/>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F3"/>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F3"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F3"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>579647</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                    <footnoteId id="F3"/>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Series B Convertible Preferred Stock</value>
                <footnoteId id="F1"/>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F3"/>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F3"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F3"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>590445</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                    <footnoteId id="F3"/>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Series C Convertible Preferred Stock</value>
                <footnoteId id="F1"/>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F3"/>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F3"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F3"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>430467</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                    <footnoteId id="F3"/>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">See Exhibit 99.1</footnote>
        <footnote id="F2">See Exhibit 99.1</footnote>
        <footnote id="F3">See Exhibit 99.1</footnote>
    </footnotes>

    <remarks>Exhibit 24 - Power of Attorney</remarks>

    <ownerSignature>
        <signatureName>KDev Investments AB By: /s/ Ulf Richenberg, attorney-in-fact</signatureName>
        <signatureDate>2019-10-02</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Karolinska Development AB By: /s/ Ulf Richenberg, attorney-in-fact</signatureName>
        <signatureDate>2019-10-02</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>KCIF Co-Investment Fund KB By: /s/ Ulf Richenberg</signatureName>
        <signatureDate>2019-10-02</signatureDate>
    </ownerSignature>
</ownershipDocument>
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<DOCUMENT>
<TYPE>EX-99
<SEQUENCE>2
<FILENAME>ex99-1k.htm
<DESCRIPTION>EXHIBIT 99.1
<TEXT>
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  <head>
    <title></title>
    <!-- Licensed to: Hogan Lovells US LLP
         Document created using EDGARfilings PROfile 6.0.0.0
         Copyright 1995 - 2019 Broadridge -->
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<body style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;" bgcolor="#ffffff">
  <div>
    <div style="text-align: right; font-weight: bold;">Exhibit&#160;99.1</div>
    <div>&#160;</div>
    <div style="text-indent: -18pt; margin-left: 18pt;">(1)<font style="font-family: 'Times New Roman', serif; font-size: 3pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font>The amount of securities of
      Aprea Therapeutics, Inc. (the &#8220;Issuer&#8221;) reported as beneficially owned includes shares held of record by: KDev Investments AB, Karolinska Development AB and KCIF Co-Investment Fund KB (collectively, the "Reporting Persons").</div>
    <div><br>
    </div>
    <div style="text-indent: -18pt; margin-left: 18pt;">(2)<font style="font-family: 'Times New Roman', serif; font-size: 3pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font>Karolinska Development AB
      (&#8220;Karolinska&#8221;) is the majority owner and co-manager of KDev Investments AB and a limited partner of KCIF Co-Investment Fund KB.&#160;&#160; Karolinska and each of the other Reporting Persons disclaim beneficial ownership of any shares of the Issuer&#8217;s Common
      Stock owned of record by any of the other Reporting Persons except to the extent of any pecuniary interest therein, and this report shall not be deemed an admission that any such entity is the beneficial owner of, or has any pecuniary interest in,
      such securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.</div>
    <div><br>
    </div>
    <div style="margin-left: 18pt;">The address of each of (i) KDev Investments AB, (ii) Karolinska Development AB, and (iii) KCIF Co-Investment Fund KB is Tomtebodav&#228;gen 23A,
      SE 171 65 Solna, Sweden.</div>
    <div><br>
    </div>
    <div style="text-indent: -18pt; margin-left: 18pt;">(3)<font style="font-family: 'Times New Roman', serif; font-size: 3pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font>These shares of Series A
      Convertible Preferred Stock, Series B Convertible Preferred Stock and Series C Convertible Preferred Stock (collectively, "Preferred Stock") will automatically be converted into shares of the Issuer's common stock, par value $0.001, on a 1-for-1
      basis, immediately prior to the completion of the Issuer's initial public offering. The Preferred Stock has no expiration date.</div>
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<DOCUMENT>
<TYPE>EX-24
<SEQUENCE>3
<FILENAME>ex24_1.htm
<DESCRIPTION>EXHIBIT 24.1
<TEXT>
<html>
  <head>
    <title></title>
    <!-- Licensed to: Hogan Lovells US LLP
         Document created using EDGARfilings PROfile 6.0.0.0
         Copyright 1995 - 2019 Broadridge -->
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<body style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;" bgcolor="#ffffff">
  <div>
    <div style="text-align: right; font-weight: bold;">Exhibit 24.1</div>
    <div><br>
    </div>
    <div style="text-align: center; margin-top: 12pt; margin-bottom: 12pt; font-weight: bold;"><u>POWER OF ATTORNEY</u></div>
    <div style="text-indent: 24.5pt; margin-top: 12pt; margin-bottom: 12pt;">The undersigned understands that, from time to time, KDev Investments AB is required to prepare,
      execute and file certain federal and state securities laws filings.</div>
    <div style="text-indent: 24.5pt; margin-top: 12pt; margin-bottom: 12pt;">Know all by these presents, that the undersigned hereby constitutes and appoints each of Ulf
      Richenberg and Fredrik J&#228;rrsten signing singly, and with full power of substitution, the undersigned&#8217;s true and lawful attorney-in-fact to:</div>
    <div style="margin-left: 21.6pt; margin-top: 12pt; margin-bottom: 12pt;">(1)&#160;prepare, execute in the name of KDev Investments AB and on behalf of KDev Investments AB, and
      submit to the U.S. Securities and Exchange Commission (the &#8220;SEC&#8221;) a Form&#160;ID, including amendments thereto, and any other documents necessary or appropriate to obtain codes and passwords enabling the undersigned to make electronic filings and reports
      required by Sections 13(d) and 16(a) of the Securities Exchange Act of 1934 (the &#8220;1934 Act&#8221;) or any rule or regulation of the SEC;</div>
    <div style="margin-left: 21.6pt; margin-top: 12pt; margin-bottom: 12pt;">(2)&#160;prepare and execute for and on behalf of KDev Investments AB, in the undersigned&#8217;s capacity as
      an authorized person, officer and/or director of KDev Investments AB, federal and state securities laws filings including without limitation Schedules 13D and 13G and Forms 3, 4, and 5 in accordance with Sections 13(d) and 16(a) of the 1934 Act and
      the rules thereunder;</div>
    <div style="margin-left: 21.6pt; margin-top: 12pt; margin-bottom: 12pt;">(3)&#160;do and perform any and all acts for and on behalf of KDev Investments AB which may be
      necessary or desirable to complete and execute any such federal and state securities laws filings including without limitation Schedules 13D and 13G and Forms 3, 4, and 5, complete and execute any amendment or amendments thereto, and timely file such
      form with the SEC and the securities administrators of any state, the District of Columbia, the Commonwealth of Puerto Rico, Guam and the United States Virgin Islands or their designees and any stock exchange or similar authority; and</div>
    <div style="margin-left: 21.6pt; margin-top: 12pt; margin-bottom: 12pt;">(4)&#160;take any other action of any type whatsoever in connection with the foregoing which, in the
      opinion of such attorney-in-fact, may be of benefit to, in the best interest of, or legally required by, the undersigned, it being understood that the documents executed by such attorney-in-fact on behalf of the undersigned pursuant to this Power of
      Attorney shall be in such form and shall contain such terms and conditions as such attorney-in-fact may approve in such attorney-in-fact&#8217;s discretion.</div>
    <div style="text-indent: 24.5pt; margin-top: 12pt; margin-bottom: 12pt;">The undersigned hereby grants to each such attorney-in-fact full power and authority to do and
      perform any and every act and thing whatsoever requisite, necessary, or proper to be done in the exercise of any of the rights and powers herein granted, as fully to all intents and purposes as the undersigned might or could do if personally present,
      with full power of substitution or revocation, hereby ratifying and confirming all that such attorney-in-fact, or such attorney-in-fact's substitute or substitutes, shall lawfully do or cause to be done by virtue of this power of attorney and the
      rights and powers herein granted.&#160; The undersigned acknowledges that the foregoing attorney-in-fact, in serving in such capacity at the request of the undersigned, is not assuming any of the undersigned&#8217;s responsibilities to comply with federal and
      state securities laws, including without limitation Section&#160;13 and Section&#160;16 of the 1934 Act.</div>
    <div style="text-indent: 24.5pt; margin-top: 12pt; margin-bottom: 12pt;">This Power of Attorney shall remain in full force and effect until KDev Investments AB is no
      longer required to file Schedules 13D and 13G and Forms 3, 4, and 5 with respect to KDev Investments AB's holdings of and transactions in securities issued by Aprea Therapeutics, Inc., unless earlier revoked by the undersigned in a signed writing
      delivered to the foregoing attorney&#8209;in&#8209;fact.</div>
    <div style="text-indent: 24.5pt; margin-top: 12pt; margin-bottom: 12pt;"> <br>
    </div>
    <div style="text-indent: 24.5pt; margin-top: 12pt; margin-bottom: 12pt;">IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to be executed as of this 2<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">nd</sup>&#160;
      day of October, 2019.</div>
    <div style="text-align: right; margin-left: 243pt; margin-top: 12pt; margin-bottom: 12pt; font-family: 'Times New Roman',Times,serif;"><u>/s/
          Viktor Drvota&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </u><br>
      Name: Viktor Drvota&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <br>
      Title: Member of the Board of Directors&#160;&#160;&#160;&#160; <br>
    </div>
    <div><br>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="page-break-after:always;" id="DSPFPageBreak">
        <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
    </div>
    <div style="text-align: center; margin-top: 12pt; margin-bottom: 12pt; font-weight: bold;"><u>POWER OF ATTORNEY</u></div>
    <div style="text-indent: 24.5pt; margin-top: 12pt; margin-bottom: 12pt;">The undersigned understands that, from time to time, Karolinska Development AB is required to
      prepare, execute and file certain federal and state securities laws filings.</div>
    <div style="text-indent: 24.5pt; margin-top: 12pt; margin-bottom: 12pt;">Know all by these presents, that the undersigned hereby constitutes and appoints each of Ulf
      Richenberg and Fredrik J&#228;rrsten signing singly, and with full power of substitution, the undersigned&#8217;s true and lawful attorney-in-fact to:</div>
    <div style="margin-left: 21.6pt; margin-top: 12pt; margin-bottom: 12pt;">(1)&#160;prepare, execute in the name of Karolinska Development AB and on behalf of Karolinska
      Development AB, and submit to the U.S. Securities and Exchange Commission (the &#8220;SEC&#8221;) a Form&#160;ID, including amendments thereto, and any other documents necessary or appropriate to obtain codes and passwords enabling the undersigned to make electronic
      filings and reports required by Sections 13(d) and 16(a) of the Securities Exchange Act of 1934 (the &#8220;1934 Act&#8221;) or any rule or regulation of the SEC;</div>
    <div style="margin-left: 21.6pt; margin-top: 12pt; margin-bottom: 12pt;">(2)&#160;prepare and execute for and on behalf of Karolinska Development AB, in the undersigned&#8217;s
      capacity as an authorized person, officer and/or director of Karolinska Development AB, federal and state securities laws filings including without limitation Schedules 13D and 13G and Forms 3, 4, and 5 in accordance with Sections 13(d) and 16(a) of
      the 1934 Act and the rules thereunder;</div>
    <div style="margin-left: 21.6pt; margin-top: 12pt; margin-bottom: 12pt;">(3)&#160;do and perform any and all acts for and on behalf of Karolinska Development AB which may be
      necessary or desirable to complete and execute any such federal and state securities laws filings including without limitation Schedules 13D and 13G and Forms 3, 4, and 5, complete and execute any amendment or amendments thereto, and timely file such
      form with the SEC and the securities administrators of any state, the District of Columbia, the Commonwealth of Puerto Rico, Guam and the United States Virgin Islands or their designees and any stock exchange or similar authority; and</div>
    <div style="margin-left: 21.6pt; margin-top: 12pt; margin-bottom: 12pt;">(4)&#160;take any other action of any type whatsoever in connection with the foregoing which, in the
      opinion of such attorney-in-fact, may be of benefit to, in the best interest of, or legally required by, the undersigned, it being understood that the documents executed by such attorney-in-fact on behalf of the undersigned pursuant to this Power of
      Attorney shall be in such form and shall contain such terms and conditions as such attorney-in-fact may approve in such attorney-in-fact&#8217;s discretion.</div>
    <div style="text-indent: 24.5pt; margin-top: 12pt; margin-bottom: 12pt;">The undersigned hereby grants to each such attorney-in-fact full power and authority to do and
      perform any and every act and thing whatsoever requisite, necessary, or proper to be done in the exercise of any of the rights and powers herein granted, as fully to all intents and purposes as the undersigned might or could do if personally present,
      with full power of substitution or revocation, hereby ratifying and confirming all that such attorney-in-fact, or such attorney-in-fact's substitute or substitutes, shall lawfully do or cause to be done by virtue of this power of attorney and the
      rights and powers herein granted.&#160; The undersigned acknowledges that the foregoing attorney-in-fact, in serving in such capacity at the request of the undersigned, is not assuming any of the undersigned&#8217;s responsibilities to comply with federal and
      state securities laws, including without limitation Section&#160;13 and Section&#160;16 of the 1934 Act.</div>
    <div style="text-indent: 24.5pt; margin-top: 12pt; margin-bottom: 12pt;">This Power of Attorney shall remain in full force and effect until Karolinska Development AB is no
      longer required to file Schedules 13D and 13G and Forms 3, 4, and 5 with respect to Karolinska Development AB's holdings of and transactions in securities issued by Aprea Therapeutics, Inc., unless earlier revoked by the undersigned in a signed
      writing delivered to the foregoing attorney&#8209;in&#8209;fact.</div>
    <div style="text-indent: 24.5pt; margin-top: 12pt; margin-bottom: 12pt;"> <br>
    </div>
    <div style="text-indent: 24.5pt; margin-top: 12pt; margin-bottom: 12pt;">IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to be executed as of this 2<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">nd</sup>&#160;
      day of October, 2019.</div>
    <div style="text-align: right; margin-left: 243pt; margin-top: 12pt; margin-bottom: 12pt; font-family: 'Times New Roman',Times,serif;"><u>/s/
          Viktor Drvota&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </u><br>
      Name: Viktor Drvota&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <br>
      Title: CEO &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160;&#160;&#160; <br>
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    <div style="text-align: center; margin-top: 12pt; margin-bottom: 12pt; font-weight: bold;"><u>POWER OF ATTORNEY</u></div>
    <div style="text-indent: 24.5pt; margin-top: 12pt; margin-bottom: 12pt;">The undersigned understands that, from time to time, KCIF Co-Investment Fund KB is required to
      prepare, execute and file certain federal and state securities laws filings.</div>
    <div style="text-indent: 24.5pt; margin-top: 12pt; margin-bottom: 12pt;">Know all by these presents, that the undersigned hereby constitutes and appoints Fredrik J&#228;rrsten
      signing singly, and with full power of substitution, the undersigned&#8217;s true and lawful attorney-in-fact to:</div>
    <div style="margin-left: 21.6pt; margin-top: 12pt; margin-bottom: 12pt;">(1)&#160;prepare, execute in the name of KCIF Co-Investment Fund KB and on behalf of KCIF Co-Investment
      Fund KB, and submit to the U.S. Securities and Exchange Commission (the &#8220;SEC&#8221;) a Form&#160;ID, including amendments thereto, and any other documents necessary or appropriate to obtain codes and passwords enabling the undersigned to make electronic filings
      and reports required by Sections 13(d) and 16(a) of the Securities Exchange Act of 1934 (the &#8220;1934 Act&#8221;) or any rule or regulation of the SEC;</div>
    <div style="margin-left: 21.6pt; margin-top: 12pt; margin-bottom: 12pt;">(2)&#160;prepare and execute for and on behalf of KCIF Co-Investment Fund KB, in the undersigned&#8217;s
      capacity as an authorized person, officer and/or director of KCIF Co-Investment Fund KB, federal and state securities laws filings including without limitation Schedules 13D and 13G and Forms 3, 4, and 5 in accordance with Sections 13(d) and 16(a) of
      the 1934 Act and the rules thereunder;</div>
    <div style="margin-left: 21.6pt; margin-top: 12pt; margin-bottom: 12pt;">(3)&#160;do and perform any and all acts for and on behalf of KCIF Co-Investment Fund KB which may be
      necessary or desirable to complete and execute any such federal and state securities laws filings including without limitation Schedules 13D and 13G and Forms 3, 4, and 5, complete and execute any amendment or amendments thereto, and timely file such
      form with the SEC and the securities administrators of any state, the District of Columbia, the Commonwealth of Puerto Rico, Guam and the United States Virgin Islands or their designees and any stock exchange or similar authority; and</div>
    <div style="margin-left: 21.6pt; margin-top: 12pt; margin-bottom: 12pt;">(4)&#160;take any other action of any type whatsoever in connection with the foregoing which, in the
      opinion of such attorney-in-fact, may be of benefit to, in the best interest of, or legally required by, the undersigned, it being understood that the documents executed by such attorney-in-fact on behalf of the undersigned pursuant to this Power of
      Attorney shall be in such form and shall contain such terms and conditions as such attorney-in-fact may approve in such attorney-in-fact&#8217;s discretion.</div>
    <div style="text-indent: 24.5pt; margin-top: 12pt; margin-bottom: 12pt;">The undersigned hereby grants to each such attorney-in-fact full power and authority to do and
      perform any and every act and thing whatsoever requisite, necessary, or proper to be done in the exercise of any of the rights and powers herein granted, as fully to all intents and purposes as the undersigned might or could do if personally present,
      with full power of substitution or revocation, hereby ratifying and confirming all that such attorney-in-fact, or such attorney-in-fact's substitute or substitutes, shall lawfully do or cause to be done by virtue of this power of attorney and the
      rights and powers herein granted.&#160; The undersigned acknowledges that the foregoing attorney-in-fact, in serving in such capacity at the request of the undersigned, is not assuming any of the undersigned&#8217;s responsibilities to comply with federal and
      state securities laws, including without limitation Section&#160;13 and Section&#160;16 of the 1934 Act.</div>
    <div style="text-indent: 24.5pt; margin-top: 12pt; margin-bottom: 12pt;">This Power of Attorney shall remain in full force and effect until KCIF Co-Investment Fund KB is
      no longer required to file Schedules 13D and 13G and Forms 3, 4, and 5 with respect to KCIF Co-Investment Fund KB's holdings of and transactions in securities issued by Aprea Therapeutics, Inc., unless earlier revoked by the undersigned in a signed
      writing delivered to the foregoing attorney&#8209;in&#8209;fact.</div>
    <div style="text-indent: 24.5pt; margin-top: 12pt; margin-bottom: 12pt;"> <br>
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    <div style="text-indent: 24.5pt; margin-top: 12pt; margin-bottom: 12pt;">IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to be executed as of this 2<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">nd</sup>
      day of October, 2019.</div>
    <div style="text-align: right; margin-left: 243pt; margin-top: 12pt; margin-bottom: 12pt; font-family: 'Times New Roman',Times,serif;"><u>/s/
          Ulf Richenberg &#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </u><br>
      Name: Ulf Richenberg &#160; &#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <br>
      Title: Chairman &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160;&#160; <br>
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