<SEC-DOCUMENT>0001104659-19-053617.txt : 20191009
<SEC-HEADER>0001104659-19-053617.hdr.sgml : 20191009
<ACCEPTANCE-DATETIME>20191009182326
ACCESSION NUMBER:		0001104659-19-053617
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20191007
FILED AS OF DATE:		20191009
DATE AS OF CHANGE:		20191009

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			5AM Ventures IV, L.P.
		CENTRAL INDEX KEY:			0001589315
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-39069
		FILM NUMBER:		191145067

	BUSINESS ADDRESS:	
		STREET 1:		2200 SAND HILL ROAD, SUITE 110
		CITY:			MENLO PARK
		STATE:			CA
		ZIP:			94025
		BUSINESS PHONE:		650-233-8600

	MAIL ADDRESS:	
		STREET 1:		2200 SAND HILL ROAD, SUITE 110
		CITY:			MENLO PARK
		STATE:			CA
		ZIP:			94025

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			5AM Co-Investors IV, L.P.
		CENTRAL INDEX KEY:			0001593361
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-39069
		FILM NUMBER:		191145068

	BUSINESS ADDRESS:	
		STREET 1:		2200 SAND HILL ROAD, SUITE 110
		CITY:			MENLO PARK
		STATE:			CA
		ZIP:			94025
		BUSINESS PHONE:		650-530-0413

	MAIL ADDRESS:	
		STREET 1:		2200 SAND HILL ROAD, SUITE 110
		CITY:			MENLO PARK
		STATE:			CA
		ZIP:			94025

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			5AM Partners IV, LLC
		CENTRAL INDEX KEY:			0001589314
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-39069
		FILM NUMBER:		191145069

	BUSINESS ADDRESS:	
		STREET 1:		2200 SAND HILL ROAD, SUITE 110
		CITY:			MENLO PARK
		STATE:			CA
		ZIP:			94025
		BUSINESS PHONE:		650-233-8600

	MAIL ADDRESS:	
		STREET 1:		2200 SAND HILL ROAD, SUITE 110
		CITY:			MENLO PARK
		STATE:			CA
		ZIP:			94025

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			5AM Opportunities I, L.P.
		CENTRAL INDEX KEY:			0001753000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-39069
		FILM NUMBER:		191145070

	BUSINESS ADDRESS:	
		STREET 1:		501 SECOND STREET, SUITE 350
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94107
		BUSINESS PHONE:		415-993-8570

	MAIL ADDRESS:	
		STREET 1:		501 SECOND STREET, SUITE 350
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94107

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			5AM Opportunities I (GP), LLC
		CENTRAL INDEX KEY:			0001790778
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-39069
		FILM NUMBER:		191145071

	BUSINESS ADDRESS:	
		STREET 1:		501 2ND STREET, SUITE 350
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94107
		BUSINESS PHONE:		(650) 233-86000

	MAIL ADDRESS:	
		STREET 1:		501 2ND STREET, SUITE 350
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94107

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			DIEKMAN JOHN D
		CENTRAL INDEX KEY:			0001240357

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-39069
		FILM NUMBER:		191145072

	MAIL ADDRESS:	
		STREET 1:		C/O 5 AM VENTURES
		STREET 2:		3000 SAND HILL RD
		CITY:			MENLO PARK
		STATE:			CA
		ZIP:			94025

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Schwab Andrew J.
		CENTRAL INDEX KEY:			0001598549

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-39069
		FILM NUMBER:		191145073

	MAIL ADDRESS:	
		STREET 1:		C/O 5AM VENTURES, 2200 SAND HILL ROAD
		STREET 2:		SUITE 110
		CITY:			MENLO PARK
		STATE:			CA
		ZIP:			94025

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			PARMAR KUSH
		CENTRAL INDEX KEY:			0001664281

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-39069
		FILM NUMBER:		191145074

	MAIL ADDRESS:	
		STREET 1:		C/O AUDENTES THERAPEUTICS, INC.
		STREET 2:		101 MONTGOMERY ST., SUITE 2650
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94104

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Aprea Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001781983
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		535 BOYLSTON STREET
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116
		BUSINESS PHONE:		6095104718

	MAIL ADDRESS:	
		STREET 1:		535 BOYLSTON STREET
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116
</SEC-HEADER>
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            <rptOwnerStateDescription></rptOwnerStateDescription>
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    <reportingOwner>
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            <rptOwnerStreet2></rptOwnerStreet2>
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            <rptOwnerZipCode>94107</rptOwnerZipCode>
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            <rptOwnerStreet2></rptOwnerStreet2>
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            <rptOwnerStreet1>501 2ND STREET, SUITE 350</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94107</rptOwnerZipCode>
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    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2019-10-07</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>C</transactionCode>
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                <value></value>
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                <sharesOwnedFollowingTransaction>
                    <value>1926073</value>
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                    <value>I</value>
                    <footnoteId id="F2"/>
                    <footnoteId id="F4"/>
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                <natureOfOwnership>
                    <value>See footnotes</value>
                    <footnoteId id="F2"/>
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        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
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                    <footnoteId id="F1"/>
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                    <value>I</value>
                    <footnoteId id="F3"/>
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                    <value>See footnotes</value>
                    <footnoteId id="F3"/>
                    <footnoteId id="F4"/>
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            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
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            <transactionDate>
                <value>2019-10-07</value>
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                <transactionFormType>4</transactionFormType>
                <transactionCode>C</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
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            <transactionTimeliness>
                <value></value>
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            <transactionAmounts>
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                    <value>492475</value>
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                <transactionPricePerShare>
                    <footnoteId id="F1"/>
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                    <value>I</value>
                    <footnoteId id="F2"/>
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                    <value>See footnotes</value>
                    <footnoteId id="F2"/>
                    <footnoteId id="F4"/>
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        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
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            <transactionDate>
                <value>2019-10-07</value>
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                <transactionFormType>4</transactionFormType>
                <transactionCode>C</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
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            <transactionTimeliness>
                <value></value>
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            <transactionAmounts>
                <transactionShares>
                    <value>20519</value>
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                <transactionPricePerShare>
                    <footnoteId id="F1"/>
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                    <value>See footnotes</value>
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                    <footnoteId id="F4"/>
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        </nonDerivativeTransaction>
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                <value>Common Stock</value>
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            <transactionDate>
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                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
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                <value></value>
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                    <value>I</value>
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                    <value>See footnotes</value>
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                <footnoteId id="F1"/>
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            <transactionDate>
                <value>2019-10-07</value>
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                <value></value>
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            <transactionAmounts>
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                <transactionPricePerShare>
                    <footnoteId id="F1"/>
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                <footnoteId id="F1"/>
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                <underlyingSecurityTitle>
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                    <value>See footnotes</value>
                    <footnoteId id="F2"/>
                    <footnoteId id="F4"/>
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        </derivativeTransaction>
        <derivativeTransaction>
            <securityTitle>
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            <transactionTimeliness>
                <value></value>
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            <transactionAmounts>
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                    <value>79746</value>
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                <transactionPricePerShare>
                    <footnoteId id="F1"/>
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                <transactionAcquiredDisposedCode>
                    <value>D</value>
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            <exerciseDate>
                <footnoteId id="F1"/>
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            <expirationDate>
                <footnoteId id="F1"/>
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            <underlyingSecurity>
                <underlyingSecurityTitle>
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                    <value>0</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                    <footnoteId id="F3"/>
                    <footnoteId id="F4"/>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnotes</value>
                    <footnoteId id="F3"/>
                    <footnoteId id="F4"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeTransaction>
        <derivativeTransaction>
            <securityTitle>
                <value>Series C Convertible Preferred Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F1"/>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2019-10-07</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>C</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>492475</value>
                </transactionShares>
                <transactionPricePerShare>
                    <footnoteId id="F1"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F1"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>492475</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>0</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                    <footnoteId id="F2"/>
                    <footnoteId id="F4"/>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnotes</value>
                    <footnoteId id="F2"/>
                    <footnoteId id="F4"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeTransaction>
        <derivativeTransaction>
            <securityTitle>
                <value>Series C Convertible Preferred Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F1"/>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2019-10-07</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>C</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>20519</value>
                </transactionShares>
                <transactionPricePerShare>
                    <footnoteId id="F1"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F1"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>20519</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>0</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                    <footnoteId id="F3"/>
                    <footnoteId id="F4"/>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnotes</value>
                    <footnoteId id="F3"/>
                    <footnoteId id="F4"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">These shares of Series B Convertible Preferred Stock and Series C Convertible Preferred Stock (collectively, &quot;Preferred Stock&quot;) automatically converted into shares of the Issuer's Common Stock (&quot;Common Stock&quot;), on a 1-for-1 basis, immediately prior to the completion of the Issuer's initial public offering for no additional consideration.  The Preferred Stock had no expiration date.</footnote>
        <footnote id="F2">Shares are held directly by 5AM Ventures IV, L.P.</footnote>
        <footnote id="F3">Shares are held directly by 5AM Co-Investors IV, L.P.</footnote>
        <footnote id="F4">5AM Partners IV, LLC is the sole general partner of each of 5AM Ventures IV, L.P. and 5AM Co-Investors IV, L.P. (collectively, the &quot;5AM IV Funds&quot;).  Dr. John D. Diekman, Andrew J. Schwab and Dr. Scott M. Rocklage are managing members of 5AM Partners IV, LLC and may be deemed to have shared voting and investment power over the shares beneficially owned by the 5AM IV Funds.  Each of 5AM Partners IV, LLC, Dr. Diekman, Mr. Schwab and Dr. Rocklage disclaims beneficial ownership of the shares of Common Stock and Preferred Stock held directly by the 5AM IV Funds, except to the extent of its or his pecuniary interest therein.</footnote>
        <footnote id="F5">Shares are held directly by 5AM Opportunities I, L.P. (&quot;Opportunities&quot;), which is under common control with the 5AM IV Funds.  The 5AM IV Funds and Opportunities expressly disclaim status as a &quot;group&quot; for purposes of this Form 4.</footnote>
        <footnote id="F6">5AM Opportunities I (GP), LLC (&quot;Opportunities GP&quot;) is the sole general partner of Opportunities.  Andrew J. Schwab and Kush Parmar are managing members of Opportunities GP and may be deemed to have shared voting and investment power over the shares beneficially owned by Opportunities.  Each of Opportunities GP, Mr. Schwab and Mr. Parmar disclaims beneficial ownership of the shares of Common Stock held directly by Opportunities, except to the extent of its or his pecuniary interest therein.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>5AM VENTURES IV, L.P. By: 5AM Partners IV, LLC, its General Partner By: /s/ Scott M. Rocklage Managing Member</signatureName>
        <signatureDate>2019-10-09</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>5AM CO-INVESTORS IV, L.P. By: 5AM Partners IV, LLC, its General Partner By: /s/ Scott M. Rocklage Managing Member</signatureName>
        <signatureDate>2019-10-09</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>5AM PARTNERS IV, LLC By: /s/ Scott M. Rocklage Managing Member</signatureName>
        <signatureDate>2019-10-09</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>5AM OPPORTUNITIES I, L.P. By: 5AM Opportunities I (GP), LLC, its General Partner By: /s/ Kush Parmar Managing Member</signatureName>
        <signatureDate>2019-10-09</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>5AM OPPORTUNITIES I (GP), LLC By: /s/ Kush Parmar Managing Member</signatureName>
        <signatureDate>2019-10-09</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ John D. Diekman</signatureName>
        <signatureDate>2019-10-09</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Andrew J. Schwab</signatureName>
        <signatureDate>2019-10-09</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Kush Parmar</signatureName>
        <signatureDate>2019-10-09</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
