<SEC-DOCUMENT>0000905148-20-001029.txt : 20200918
<SEC-HEADER>0000905148-20-001029.hdr.sgml : 20200918
<ACCEPTANCE-DATETIME>20200918170414
ACCESSION NUMBER:		0000905148-20-001029
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20200916
FILED AS OF DATE:		20200918
DATE AS OF CHANGE:		20200918

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Wessels Gregory S.
		CENTRAL INDEX KEY:			0001824615

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-39069
		FILM NUMBER:		201184594

	MAIL ADDRESS:	
		STREET 1:		535 BOYLSTON STREET
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Aprea Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001781983
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		535 BOYLSTON STREET
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116
		BUSINESS PHONE:		6095104718

	MAIL ADDRESS:	
		STREET 1:		535 BOYLSTON STREET
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116
</SEC-HEADER>
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<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2020-09-16</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001781983</issuerCik>
        <issuerName>Aprea Therapeutics, Inc.</issuerName>
        <issuerTradingSymbol>APRE</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001824615</rptOwnerCik>
            <rptOwnerName>Wessels Gregory S.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>535 BOYLSTON STREET</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>BOSTON</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02116</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isOfficer>true</isOfficer>
            <officerTitle>SVP, Chief Commercial Officer</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Stock Options (Right to Buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>34.8</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2030-02-10</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>30000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Twenty-five percent of these options vest on February 10, 2021, with the remaining options vesting ratably over the following 36 months, subject to the reporting person's continued employment through and including the applicable vesting date and subject to acceleration under certain conditions.</footnote>
    </footnotes>

    <remarks>Exhibit 24 - Power of Attorney</remarks>

    <ownerSignature>
        <signatureName>/s/ Scott M. Coiante, attorney-in-fact</signatureName>
        <signatureDate>2020-09-18</signatureDate>
    </ownerSignature>
</ownershipDocument>
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<TYPE>EX-24
<SEQUENCE>2
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  <div style="text-align: right;"><font style="font-weight: bold;">Exhibit 24</font><br>
  </div>
  <div><br>
  </div>
  <div>
    <div style="text-align: center; line-height: 12.55pt; font-weight: bold;">POWER OF ATTORNEY</div>
    <div style="line-height: 12.55pt">&#160;</div>
    <div style="text-indent: 36pt; line-height: 12.55pt;">Know all by these presents, that the undersigned hereby makes, constitutes and appoints each of Christian S. Schade and Scott M. Coiante, or either of them acting individually, and with full power
      of substitution, the undersigned's true and lawful attorney-in-fact to:</div>
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              <div style="margin-left: 27pt; line-height: 12.55pt; color: #1F1F1F;">(1)</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="line-height: 12.55pt; color: #1F1F1F;">prepare, execute in the undersigned's name and on the undersigned's behalf, and submit to the U.S. Securities and Exchange Commission (the "SEC") a Form ID, including amendments thereto, and
                any other documents necessary or appropriate to obtain codes and passwords enabling the undersigned to make electronic filings with the SEC of reports required by Section 16(a) of the Securities Exchange Act of 1934 or any rule or
                regulation of the SEC;<br>
                <br>
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              <div style="margin-left: 27pt; line-height: 12.55pt; color: #1F1F1F;">(2)</div>
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            <td style="width: auto; vertical-align: top;">
              <div style="line-height: 12.55pt;"><font style="color: #1F1F1F;">execute for and on behalf of the undersigned, in the undersigned's capacity as an officer and/or director of </font>Aprea Therapeutics, Inc. <font style="color: #1F1F1F;">a
                  Delaware corporation (the "Company"), Forms 3, 4, and 5, including amendments thereto, in accordance with Section 16(a) of the Securities Exchange Act of 1934 and the rules and regulations thereunder;</font></div>
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                </font></div>
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              <div style="margin-left: 27pt; line-height: 12.55pt;">(3)</div>
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            <td style="width: auto; vertical-align: top;">
              <div style="line-height: 12.55pt; color: #1F1F1F;">do and perform any and all acts for and on behalf of the undersigned which may be necessary or desirable to complete and execute any such Form 3, 4, or 5, complete and execute any amendment
                or amendments thereto, and timely file such form with the SEC and any stock exchange or similar authority; and</div>
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              <div style="margin-left: 27pt; line-height: 12.55pt;">(4)</div>
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            <td style="width: auto; vertical-align: top;">
              <div style="line-height: 12.55pt; color: #1F1F1F;">take any other action of any type whatsoever in connection with the foregoing which, in the opinion of such attorney-in-fact, may be of benefit to, in the best interest of, or legally
                required by, the undersigned, it being understood that the documents executed by such attorney-in-fact on behalf of the undersigned pursuant to this Power of Attorney shall be in such form and shall contain such terms and conditions as such
                attorney-in-fact may approve in such attorney-in-fact's discretion.</div>
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    <div style="text-indent: 36pt; line-height: 12.55pt; color: #1F1F1F;"> <br>
    </div>
    <div style="text-indent: 36pt; line-height: 12.55pt; color: #1F1F1F;">The undersigned hereby grants to each such attorney-in-fact full power and authority to do and perform any and every act and thing whatsoever requisite, necessary, or proper to be
      done in the exercise of any of the rights and powers herein granted, as fully to all intents and purposes as the undersigned might or could do if personally present, with full power of substitution or revocation, hereby ratifying and confirming all
      that such attorney-in-fact, or such attorney-in-fact's substitute or substitutes, shall lawfully do or cause to be done by virtue of this power of attorney and the rights and powers herein granted. The undersigned acknowledges that the foregoing
      attorneys-in-fact, in serving in such capacity at the request of the undersigned, are not assuming, nor is the Company assuming, any of the undersigned's responsibilities to comply with Section 16 of the Securities Exchange Act of 1934.</div>
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    </div>
    <div style="text-indent: 36pt; line-height: 12.55pt;"><font style="color: #1F1F1F;">This Power of Attorney shall remain in full force and effect until the undersigned is no longer required to file Forms 3, 4, and 5 with respect to the undersigned's
        holdings of and transactions in securities issued by the Company, unless earlier (a) revoked by the undersigned </font><font style="color: #3F3F3F;">i</font><font style="color: #1F1F1F;">n a signed writing delivered to the foregoing
        attorneys-in-fact or (b) superseded by a new power of attorney regarding the purposes outlined herein at a later date.</font></div>
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    </div>
    <div style="line-height: 12.55pt; font-family: 'Times New Roman',Times,serif; text-indent: 36pt;">IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to be executed as of this 17th <font style="color: rgb(31, 31, 31);">day of </font>September,<font style="color: rgb(31, 31, 31);"> 2020.</font></div>
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            <td colspan="2" style="width: 38%; border-bottom: 2px solid rgb(0, 0, 0); text-align: center; vertical-align: bottom;"><strong></strong>/s/ Gregory Wessels<br>
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            <td rowspan="1" colspan="2" style="width: 38%; text-align: center; vertical-align: bottom;">Signature<br>
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            <td rowspan="1" colspan="2" style="width: 38%; border-bottom: 2px solid rgb(0, 0, 0); text-align: center; vertical-align: bottom;">Gregory Wessels<br>
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            <td rowspan="1" colspan="2" style="width: 38%; text-align: center; vertical-align: bottom;">Print Name<br>
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            <td valign="top" style="width: 3%;">&#160;</td>
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