<SEC-DOCUMENT>0001558370-20-004661.txt : 20200429
<SEC-HEADER>0001558370-20-004661.hdr.sgml : 20200429
<ACCEPTANCE-DATETIME>20200429164057
ACCESSION NUMBER:		0001558370-20-004661
CONFORMED SUBMISSION TYPE:	DEFA14A
PUBLIC DOCUMENT COUNT:		7
FILED AS OF DATE:		20200429
DATE AS OF CHANGE:		20200429
EFFECTIVENESS DATE:		20200429

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Aprea Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001781983
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		DEFA14A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-39069
		FILM NUMBER:		20830993

	BUSINESS ADDRESS:	
		STREET 1:		535 BOYLSTON STREET
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116
		BUSINESS PHONE:		6095104718

	MAIL ADDRESS:	
		STREET 1:		535 BOYLSTON STREET
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116
</SEC-HEADER>
<DOCUMENT>
<TYPE>DEFA14A
<SEQUENCE>1
<FILENAME>tmb-20200429xdefa14a.htm
<DESCRIPTION>DEFA14A
<TEXT>
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			apre_Current_Folio_DEFA14A
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	<body><div style="margin-left:5.88235294117647%;margin-right:5.88235294117647%;"></div><div style="margin-left:5.88235294117647%;margin-right:5.88235294117647%;">
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			<font style="display:inline;font-family:Times New Roman,Times,serif;font-weight:bold;color:#000000;font-size:16pt;">UNITED STATES</font>
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			<font style="display:inline;font-family:Times New Roman,Times,serif;font-weight:bold;color:#000000;font-size:16pt;">SECURITIES AND EXCHANGE COMMISSION</font>
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		<p style="margin:0pt 0pt 10pt;text-align:center;font-family:Times New Roman,Times,serif;font-size: 16pt;">
			<font style="display:inline;font-family:Times New Roman,Times,serif;font-weight:bold;color:#000000;font-size:16pt;">Washington, D.C. 20549</font>
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		<p style="margin:0pt 0pt 10pt;text-align:center;font-family:Times New Roman,Times,serif;font-size: 16pt;">
			<font style="display:inline;font-family:Times New Roman,Times,serif;font-weight:bold;color:#000000;font-size:16pt;">SCHEDULE 14A</font>
		</p>
		<p style="margin:0pt;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
			<font style="display:inline;font-family:Times New Roman,Times,serif;color:#000000;">Proxy Statement Pursuant to Section&nbsp;14(a)&nbsp;of the Securities Exchange Act of 1934</font>
		</p>
		<p style="margin:0pt 0pt 16pt;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
			<font style="display:inline;font-family:Times New Roman,Times,serif;color:#000000;">(Amendment No.&nbsp;___)</font>
		</p>
		<p style="margin:0pt 0pt 0pt 10.8pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
			<font style="display:inline;font-family:Segoe UI Symbol;color:#000000;">&#x2612;</font><font style="display:inline;font-family:Times New Roman,Times,serif;color:#000000;"> Filed by the Registrant&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font><font style="display:inline;font-family:Segoe UI Symbol;color:#000000;">&#x2610;</font><font style="display:inline;font-family:Times New Roman,Times,serif;color:#000000;">&nbsp;&nbsp;&nbsp;&nbsp;Filed by a party other than the Registrant</font>
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		<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
			<font style="display:inline;">&nbsp;</font>
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		<div style="width:100%;"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse:collapse;width: 100.00%;">
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					<p style="margin:3pt 0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Times New Roman,Times,serif;font-weight:bold;">Check the appropriate box:</font><font style="display:inline;font-family:Times New Roman,Times,serif;font-size:3pt;">&nbsp;</font></p>
				</td>
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				<td valign="top" style="width:100.00%;border-left:1pt solid #000000 ;border-right:1pt solid #000000 ;padding:0pt 2pt 0pt 8pt;">
					<p style="margin:0pt 0pt 0pt 24pt;text-indent: -24pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Segoe UI Symbol;">&#x2610;</font><font style="display:inline;font-family:Times New Roman,Times,serif;font-weight:bold;">&#x2002;&#x2009;&#x2009;Preliminary Proxy Statement</font></p>
				</td>
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				<td valign="top" style="width:100.00%;border-left:1pt solid #000000 ;border-right:1pt solid #000000 ;padding:0pt 2pt 0pt 8pt;">
					<p style="margin:0pt 0pt 0pt 24pt;text-indent: -24pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Segoe UI Symbol;">&#x2610;</font><font style="display:inline;font-family:Times New Roman,Times,serif;font-weight:bold;">&#x2002;&#x2009;&#x2009;Confidential, for Use of the Commission Only (as permitted by Rule&nbsp;14a&#8209;6(e)(2))</font></p>
				</td>
			</tr>
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				<td valign="top" style="width:100.00%;border-left:1pt solid #000000 ;border-right:1pt solid #000000 ;padding:0pt 2pt 0pt 8pt;">
					<p style="margin:0pt 0pt 0pt 24pt;text-indent: -24pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Segoe UI Symbol;">&#x2610;</font><font style="display:inline;font-family:Times New Roman,Times,serif;font-weight:bold;">&#x2002;&#x2009;&#x2009;Definitive Proxy Statement</font></p>
				</td>
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					<p style="margin:0pt 0pt 0pt 24pt;text-indent: -24pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Segoe UI Symbol;">&#x2612;</font><font style="display:inline;font-family:Times New Roman,Times,serif;font-weight:bold;">&#x2002;&#x2009;&#x2009;Definitive Additional Materials</font></p>
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					<p style="margin:0pt 0pt 3pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Segoe UI Symbol;">&#x2610;</font><font style="display:inline;font-family:Times New Roman,Times,serif;font-weight:bold;">&#x2002;&#x2009;&#x2009;Soliciting Material under&nbsp;&#xA7;240.14a&#8209;12</font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:0pt;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
			<font style="display:inline;">&nbsp;</font>
		</p>
		<p style="margin:0pt;text-align:center;font-family:Times New Roman,Times,serif;font-size: 22pt;">
			<font style="display:inline;font-family:Times New Roman,Times,serif;font-weight:bold;color:#000000;font-size:22pt;">Aprea Therapeutics,&nbsp;Inc.</font>
		</p>
		<p style="margin:0pt;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
			<font style="display:inline;font-family:Times New Roman,Times,serif;color:#000000;">(Name of Registrant as Specified in Its Charter)</font>
		</p>
		<p style="margin:0pt;text-align:center;color:#000000;font-family:Times New Roman,Times,serif;font-size: 10pt;">
			<font style="display:inline;font-family:Times New Roman,Times,serif;">&nbsp;</font>
		</p>
		<p style="margin:0pt;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
			<font style="display:inline;font-family:Times New Roman,Times,serif;color:#000000;">(Name of Person(s)&nbsp;Filing Proxy Statement, if other than the Registrant)</font>
		</p>
		<p style="margin:0pt;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
			<font style="display:inline;">&nbsp;</font>
		</p>
		<div style="width:100%;"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse:collapse;width: 100.16%;">
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					<p style="margin:0pt;font-family:Times New Roman,Times,serif;height:1.00pt;overflow:hidden;font-size:0pt;">
						<font style="display:inline;font-size:1pt;">&nbsp;</font></p>
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				<td valign="bottom" style="width:01.40%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;height:1.00pt;overflow:hidden;font-size:0pt;">
						<font style="display:inline;font-size:1pt;">&nbsp;</font></p>
				</td>
				<td valign="bottom" style="width:02.94%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;height:1.00pt;overflow:hidden;font-size:0pt;">
						<font style="display:inline;font-size:1pt;">&nbsp;</font></p>
				</td>
				<td valign="bottom" style="width:92.22%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;height:1.00pt;overflow:hidden;font-size:0pt;">
						<font style="display:inline;font-size:1pt;">&nbsp;</font></p>
				</td>
			</tr>
			<tr>
				<td colspan="4" valign="top" style="width:100.00%;border-top:1pt solid #000000 ;border-left:1pt solid #000000 ;border-bottom:1pt solid #000000 ;border-right:1pt solid #000000 ;padding:0pt 2pt 0pt 8pt;">
					<p style="margin:6pt 0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Times New Roman,Times,serif;">Payment of Filing Fee (Check the appropriate box):&nbsp;</font></p>
				</td>
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			<tr>
				<td valign="top" style="width:03.44%;border-left:1pt solid #000000 ;padding:0pt 0pt 0pt 8pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Segoe UI Symbol;">&#x2612;</font></p>
				</td>
				<td valign="bottom" style="width:01.40%;padding:0pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;">&nbsp;</font></p>
				</td>
				<td colspan="2" valign="top" style="width:95.16%;border-right:1pt solid #000000 ;padding:0pt 2pt 0pt 0pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Times New Roman,Times,serif;font-weight:bold;">No fee required.</font></p>
				</td>
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			<tr>
				<td valign="top" style="width:03.44%;border-left:1pt solid #000000 ;padding:0pt 0pt 0pt 8pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;">&nbsp;</font></p>
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				<td valign="bottom" style="width:01.40%;padding:0pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;">&nbsp;</font></p>
				</td>
				<td colspan="2" valign="top" style="width:95.16%;border-right:1pt solid #000000 ;padding:0pt 2pt 0pt 0pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;">&nbsp;</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:03.44%;border-left:1pt solid #000000 ;padding:0pt 0pt 0pt 8pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Segoe UI Symbol;">&#x2610;</font></p>
				</td>
				<td valign="bottom" style="width:01.40%;padding:0pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;">&nbsp;</font></p>
				</td>
				<td colspan="2" valign="top" style="width:95.16%;border-right:1pt solid #000000 ;padding:0pt 2pt 0pt 0pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Times New Roman,Times,serif;font-weight:bold;">Fee computed on table below per Exchange Act Rules&nbsp;14a&#8209;6(i)(1)&nbsp;and&nbsp;0&#8209;11.</font></p>
				</td>
			</tr>
			<tr>
				<td valign="bottom" style="width:03.44%;border-left:1pt solid #000000 ;padding:0pt 0pt 0pt 8pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;">&nbsp;</font></p>
				</td>
				<td valign="bottom" style="width:01.40%;padding:0pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;">&nbsp;</font></p>
				</td>
				<td valign="bottom" style="width:02.94%;padding:0pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Times New Roman,Times,serif;">(1)</font></p>
				</td>
				<td valign="bottom" style="width:92.22%;border-right:1pt solid #000000 ;padding:0pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Times New Roman,Times,serif;">Title of each class of securities to which transaction applies:</font></p>
				</td>
			</tr>
			<tr>
				<td valign="bottom" style="width:03.44%;border-left:1pt solid #000000 ;padding:0pt 0pt 0pt 8pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;">&nbsp;</font></p>
				</td>
				<td valign="bottom" style="width:01.40%;padding:0pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;">&nbsp;</font></p>
				</td>
				<td valign="bottom" style="width:02.94%;padding:0pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Times New Roman,Times,serif;">(2)</font></p>
				</td>
				<td valign="bottom" style="width:92.22%;border-right:1pt solid #000000 ;padding:0pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Times New Roman,Times,serif;">Aggregate number of securities to which transaction applies:</font></p>
				</td>
			</tr>
			<tr>
				<td valign="bottom" style="width:03.44%;border-left:1pt solid #000000 ;padding:0pt 0pt 0pt 8pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;">&nbsp;</font></p>
				</td>
				<td valign="bottom" style="width:01.40%;padding:0pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;">&nbsp;</font></p>
				</td>
				<td valign="bottom" style="width:02.94%;padding:0pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;">&nbsp;</font></p>
				</td>
				<td valign="bottom" style="width:92.22%;border-right:1pt solid #000000 ;padding:0pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Times New Roman,Times,serif;">Per unit price or other underlying value of transaction computed pursuant to Exchange Act Rule&nbsp;0&#8209;11</font></p>
				</td>
			</tr>
			<tr>
				<td valign="bottom" style="width:03.44%;border-left:1pt solid #000000 ;padding:0pt 0pt 0pt 8pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;">&nbsp;</font></p>
				</td>
				<td valign="bottom" style="width:01.40%;padding:0pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;">&nbsp;</font></p>
				</td>
				<td valign="bottom" style="width:02.94%;padding:0pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Times New Roman,Times,serif;">(3)</font></p>
				</td>
				<td valign="bottom" style="width:92.22%;border-right:1pt solid #000000 ;padding:0pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Times New Roman,Times,serif;">(set forth the amount on which the filing fee is calculated and state how it was determined):</font></p>
				</td>
			</tr>
			<tr>
				<td valign="bottom" style="width:03.44%;border-left:1pt solid #000000 ;padding:0pt 0pt 0pt 8pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;">&nbsp;</font></p>
				</td>
				<td valign="bottom" style="width:01.40%;padding:0pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;">&nbsp;</font></p>
				</td>
				<td valign="bottom" style="width:02.94%;padding:0pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Times New Roman,Times,serif;">(4)</font></p>
				</td>
				<td valign="bottom" style="width:92.22%;border-right:1pt solid #000000 ;padding:0pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Times New Roman,Times,serif;">Proposed maximum aggregate value of transaction:</font></p>
				</td>
			</tr>
			<tr>
				<td valign="bottom" style="width:03.44%;border-left:1pt solid #000000 ;padding:0pt 0pt 0pt 8pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;">&nbsp;</font></p>
				</td>
				<td valign="bottom" style="width:01.40%;padding:0pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;">&nbsp;</font></p>
				</td>
				<td valign="bottom" style="width:02.94%;padding:0pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Times New Roman,Times,serif;">(5)</font></p>
				</td>
				<td valign="bottom" style="width:92.22%;border-right:1pt solid #000000 ;padding:0pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Times New Roman,Times,serif;">Total fee paid:</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:03.44%;border-left:1pt solid #000000 ;padding:0pt 0pt 0pt 8pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;">&nbsp;</font></p>
				</td>
				<td valign="bottom" style="width:01.40%;padding:0pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;">&nbsp;</font></p>
				</td>
				<td colspan="2" valign="top" style="width:95.16%;border-right:1pt solid #000000 ;padding:0pt 2pt 0pt 0pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;">&nbsp;</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:03.44%;border-left:1pt solid #000000 ;padding:0pt 0pt 0pt 8pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Segoe UI Symbol;">&#x2610;</font></p>
				</td>
				<td valign="bottom" style="width:01.40%;padding:0pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;">&nbsp;</font></p>
				</td>
				<td colspan="2" valign="top" style="width:95.16%;border-right:1pt solid #000000 ;padding:0pt 2pt 0pt 0pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Times New Roman,Times,serif;font-weight:bold;">Fee paid previously with preliminary materials.</font></p>
				</td>
			</tr>
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					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Segoe UI Symbol;">&#x2610;</font></p>
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					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Times New Roman,Times,serif;font-weight:bold;">Check box if any part of the fee is offset as provided by Exchange Act Rule&nbsp;0&#8209;11(a)(2)&nbsp;and identify the filing for which the offsetting fee was paid previously. Identify the previous filing by registration statement number, or the Form&nbsp;or Schedule and the date of its filing.</font></p>
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					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Times New Roman,Times,serif;">(1)</font></p>
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					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Times New Roman,Times,serif;">Amount Previously Paid:</font></p>
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					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Times New Roman,Times,serif;">(2)</font></p>
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					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Times New Roman,Times,serif;">Form, Schedule or Registration Statement No.:</font></p>
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					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Times New Roman,Times,serif;">(3)</font></p>
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					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Times New Roman,Times,serif;">Filing Party:</font></p>
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					<p style="margin:0pt 0pt 2pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Times New Roman,Times,serif;">(4)</font></p>
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					<p style="margin:0pt 0pt 2pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Times New Roman,Times,serif;">Date Filed:</font></p>
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		<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
			<font style="display:inline;">&nbsp;</font>
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			&nbsp;
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		<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
			<font style="display:inline;"></font></p></div><div style="margin-left:5.88235294117647%;margin-right:5.88235294117647%;">
		<p><font size="1"> </font></p></div><div style="margin-left:5.88235294117647%;margin-right:5.88235294117647%;page-break-after:always;"><div style="background-color:#000000;clear:both;height:2pt;border:0;margin:30pt 0pt 30pt 0pt;"></div></div><div style="margin-left:5.88235294117647%;margin-right:5.88235294117647%;"></div><div style="margin-left:5.88235294117647%;margin-right:5.88235294117647%;"><p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;"><font style="display:inline;"></font>
		</p>
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			<font style="display:inline;font-family:Arial,Helvetica,sans-serif;font-size:6pt;">&nbsp;</font>
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		<p style="margin:0pt;text-align:right;font-family:Times New Roman,Times,serif;font-size: 20pt;">
			<font style="display:inline;font-family:Arial,Helvetica,sans-serif;font-weight:bold;font-size:20pt;">+</font>
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						<font style="display:inline;font-family:Arial,Helvetica,sans-serif;">&nbsp;</font></p>
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						<font style="display:inline;font-family:Arial,Helvetica,sans-serif;">&nbsp;</font></p>
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						<font style="display:inline;font-family:Arial,Helvetica,sans-serif;">&nbsp;</font></p>
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					<p style="margin:0pt 0pt 5pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Arial,Helvetica,sans-serif;">Online</font></p>
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Arial,Helvetica,sans-serif;">Go to www.envisionreports.com/APRE or scan the QR code &#x2014; login details are located in the shaded bar below.</font></p>
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			<font style="display:inline;font-family:Arial,Helvetica,sans-serif;">&nbsp;</font>
		</p>
		<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
			<font style="display:inline;font-family:Arial,Helvetica,sans-serif;">&nbsp;</font>
		</p>
		<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
			<font style="display:inline;font-family:Arial,Helvetica,sans-serif;">&nbsp;</font>
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					<p style="margin:5pt 0pt 5pt 7.2pt;font-family:Times New Roman,Times,serif;font-size: 13pt;">
						<font style="display:inline;font-family:Arial,Helvetica,sans-serif;font-size:13pt;">Stockholder Meeting Notice</font></p>
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			<font style="display:inline;font-family:Arial,Helvetica,sans-serif;">&nbsp;</font>
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		<p style="margin:0pt;text-align:center;color:#2B2A29;font-family:Times New Roman,Times,serif;font-size: 13pt;">
			<font style="display:inline;font-family:Arial,Helvetica,sans-serif;color:#2B2A29;font-size:13pt;">Important Notice Regarding the Availability of Proxy Materials for the</font>
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		<p style="margin:0pt;text-align:center;color:#2B2A29;font-family:Times New Roman,Times,serif;font-size: 13pt;">
			<font style="display:inline;font-family:Arial,Helvetica,sans-serif;color:#2B2A29;font-size:13pt;">Aprea Therapeutics, Inc. Stockholder Meeting to be Held on Friday, June 26, 2020, 9:00 A.M. Eastern Time</font>
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		<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
			<font style="display:inline;font-family:Arial,Helvetica,sans-serif;">&nbsp;</font>
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		<p style="margin:0pt 0pt 0.05pt 1pt;color:#2B2A29;font-family:Times New Roman,Times,serif;font-size: 11pt;">
			<font style="display:inline;font-family:Arial,Helvetica,sans-serif;color:#2B2A29;font-size:11pt;">Under Securities and Exchange Commission rules, you are receiving this notice that the proxy materials for the annual stockholders&#x2019; meeting are available on the Internet. Follow the instructions below to view the materials and vote online or request a copy. The items to be voted on and location of the annual meeting are on the reverse side. Your vote is important!</font>
		</p>
		<p style="margin:0pt;color:#2B2A29;font-family:Times New Roman,Times,serif;font-size: 10pt;">
			<font style="display:inline;font-family:Arial,Helvetica,sans-serif;">&nbsp;</font>
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		<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 11pt;">
			<font style="display:inline;font-family:Arial,Helvetica,sans-serif;color:#2B2A29;font-size:11pt;">This communication presents only an overview of the more complete proxy materials that are available to you on the Internet. We encourage you to access and review all of the important information contained in the proxy materials before voting. The 2020 proxy statement and the 2019 annual report are available at:</font>
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		<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
			<font style="display:inline;font-family:Arial,Helvetica,sans-serif;">&nbsp;</font>
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						<font style="display:inline;"><img src="tmb-20200429xdefa14ag002.jpg" style="width: 0.2708333in; height: 0.5208333in" alt="Picture 3"></font></p>
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					<p style="margin:0pt;text-align:center;font-family:Times New Roman,Times,serif;font-size: 20pt;">
						<font style="display:inline;font-family:Arial,Helvetica,sans-serif;color:#2B2A29;font-size:20pt;">www.envisionreports.com/APRE</font></p>
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					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;"><img src="tmb-20200429xdefa14ag003.jpg" style="width: 0.2708333in; height: 0.5208333in" alt="Picture 2"></font></p>
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		<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 1pt;">
			<font style="display:inline;font-family:Arial,Helvetica,sans-serif;font-size:1pt;">&nbsp;</font>
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					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 17pt;">
						<font style="display:inline;font-family:Arial,Helvetica,sans-serif;font-size:17pt;">&nbsp;</font></p>
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					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 17pt;">
						<font style="display:inline;font-family:Arial,Helvetica,sans-serif;color:#2B2A29;font-size:17pt;">Easy Online Access &#x2014; View your proxy materials and vote.</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;width:12.08%;background-color: #auto;padding:0pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 11pt;">
						<font style="display:inline;font-size:11pt;"><img src="tmb-20200429xdefa14ag004.jpg" style="width: 0.6875in; height: 0.6458333in" alt="Picture 7"></font></p>
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					<p style="margin:0pt;color:#2B2A29;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Arial,Helvetica,sans-serif;">&nbsp;</font></p>
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 11pt;">
						<font style="display:inline;font-family:Arial,Helvetica,sans-serif;color:#2B2A29;font-size:11pt;">Step 1:&nbsp;&nbsp;&nbsp;&nbsp;Go to www.envisionreports.com/APRE</font></p>
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 11pt;">
						<font style="display:inline;font-family:Arial,Helvetica,sans-serif;color:#2B2A29;font-size:11pt;">Step 2:&nbsp;&nbsp;&nbsp;&nbsp;Click on Cast Your Vote or Request Materials.</font></p>
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 11pt;">
						<font style="display:inline;font-family:Arial,Helvetica,sans-serif;color:#2B2A29;font-size:11pt;">Step 3:&nbsp;&nbsp;&nbsp;&nbsp;Follow the instructions on the screen to log in.</font></p>
					<p style="margin:0pt;text-align:justify;text-justify:inter-ideograph;font-family:Times New Roman,Times,serif;font-size: 11pt;">
						<font style="display:inline;font-family:Arial,Helvetica,sans-serif;color:#2B2A29;font-size:11pt;">Step 4:&nbsp;&nbsp;&nbsp;&nbsp;Make your selections as instructed on each screen for your delivery preferences.</font></p>
					<p style="margin:0pt;color:#2B2A29;font-family:Times New Roman,Times,serif;font-size: 11pt;">
						<font style="display:inline;font-family:Arial,Helvetica,sans-serif;color:#2B2A29;font-size:11pt;">Step 5:&nbsp;&nbsp;&nbsp;&nbsp;Vote your shares.</font></p>
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			<font style="display:inline;font-family:Arial,Helvetica,sans-serif;">&nbsp;</font>
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		<p style="margin:0pt;color:#2B2A29;font-family:Times New Roman,Times,serif;font-size: 11pt;">
			<font style="display:inline;font-family:Arial,Helvetica,sans-serif;color:#2B2A29;font-size:11pt;">When you go online, you can also help the environment by consenting to receive electronic delivery of future materials.</font>
		</p>
		<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
			<font style="display:inline;font-family:Arial,Helvetica,sans-serif;">&nbsp;</font>
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					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 11pt;">
						<font style="display:inline;font-size:11pt;"><img src="tmb-20200429xdefa14ag005.jpg" style="width: 0.4686909in; height: 0.5728456in" alt="Picture 10"></font></p>
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					<p style="margin:0pt;color:#2B2A29;font-family:Times New Roman,Times,serif;font-size: 11pt;">
						<font style="display:inline;font-family:Arial,Helvetica,sans-serif;color:#2B2A29;font-size:11pt;">Obtaining a Copy of the Proxy Materials - If you want to receive a copy of the proxy materials, you must request one. There is no charge to you for requesting a copy. Please make your request as instructed on the reverse side on or before June 12, 2020 to facilitate timely delivery.</font></p>
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						<font style="display:inline;"><img src="tmb-20200429xdefa14ag006.jpg" style="width: 0.2603838in; height: 0.2395538in" alt="Picture 12"></font></p>
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						<font style="display:inline;font-family:Arial,Helvetica,sans-serif;color:#2B2A29;font-size:12pt;">2NOT</font></p>
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						<font style="display:inline;font-family:Arial,Helvetica,sans-serif;font-weight:bold;font-size:20pt;">+</font></p>
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						<font style="display:inline;font-family:Arial,Helvetica,sans-serif;font-size:6pt;">039BBC</font></p>
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			<font style="display:inline;"></font></p></div><div style="margin-left:5.88235294117647%;margin-right:5.88235294117647%;">
		<p><font size="1"> </font></p></div><div style="margin-left:5.88235294117647%;margin-right:5.88235294117647%;page-break-after:always;"><div style="background-color:#000000;clear:both;height:2pt;border:0;margin:30pt 0pt 30pt 0pt;"></div></div><div style="margin-left:5.88235294117647%;margin-right:5.88235294117647%;"></div><div style="margin-left:5.88235294117647%;margin-right:5.88235294117647%;"><p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;"><font style="display:inline;"></font>
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			<font style="display:inline;font-family:Arial,Helvetica,sans-serif;">&nbsp;</font>
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			<font style="display:inline;font-family:Arial,Helvetica,sans-serif;">&nbsp;</font>
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		<div style="width:100%;"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse:collapse;width: 100.00%;background-color: #E4E4E4;font-family:Times New Roman,Times,serif;">
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					<p style="margin:5pt 0pt 5pt 7.2pt;font-family:Times New Roman,Times,serif;font-size: 13pt;">
						<font style="display:inline;font-family:Arial,Helvetica,sans-serif;font-size:13pt;">Stockholder Meeting Notice</font></p>
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		<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
			<font style="display:inline;font-family:Arial,Helvetica,sans-serif;">&nbsp;</font>
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		<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 12pt;">
			<font style="display:inline;font-family:Arial,Helvetica,sans-serif;color:#2B2A29;font-size:12pt;">The 2020 Annual Meeting of Stockholders of Aprea Therapeutics, Inc.&nbsp;&nbsp;will be held on Friday, June 26, 2020, 9:00 A.M. Eastern Time, virtually via the internet at www.meetingcenter.io/233593541. To access the virtual meeting, you must have the information that is printed in the shaded bar located on the reverse side of this form. The password for this meeting is APRE2020.</font>
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		<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
			<font style="display:inline;font-family:Arial,Helvetica,sans-serif;">&nbsp;</font>
		</p>
		<p style="margin:0pt 0pt 0pt 1pt;color:#2B2A29;font-family:Times New Roman,Times,serif;font-size: 10pt;">
			<font style="display:inline;font-family:Arial,Helvetica,sans-serif;color:#2B2A29;">Proposals to be voted on at the meeting are listed below along with the Board of Directors&#x2019; recommendations.</font>
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			<font style="display:inline;font-family:Arial,Helvetica,sans-serif;">&nbsp;</font>
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		<p style="margin:0pt 0pt 0pt 1pt;color:#2B2A29;font-family:Times New Roman,Times,serif;font-size: 10pt;">
			<font style="display:inline;font-family:Arial,Helvetica,sans-serif;color:#2B2A29;">The Board of Directors recommend a vote </font><font style="display:inline;font-family:Arial,Helvetica,sans-serif;color:#2B2A29;text-decoration:underline;">FOR</font><font style="display:inline;font-family:Arial,Helvetica,sans-serif;color:#2B2A29;"> all the nominees listed and </font><font style="display:inline;font-family:Arial,Helvetica,sans-serif;color:#2B2A29;text-decoration:underline;">FOR</font><font style="display:inline;font-family:Arial,Helvetica,sans-serif;color:#2B2A29;"> Proposal 2:</font>
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		<p style="margin:0pt 0pt 0pt 18pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
			<font style="display:inline;font-family:Arial,Helvetica,sans-serif;color:#2B2A29;">1.&nbsp;&nbsp;&nbsp;&nbsp;Election of Directors:</font>
		</p>
		<p style="margin:0pt 0pt 0pt 37pt;color:#2B2A29;font-family:Times New Roman,Times,serif;font-size: 10pt;">
			<font style="display:inline;font-family:Arial,Helvetica,sans-serif;color:#2B2A29;">01 - Bernd R. Seizinger, M.D., Ph.D.</font>
		</p>
		<p style="margin:0pt 0pt 0pt 37pt;color:#2B2A29;font-family:Times New Roman,Times,serif;font-size: 10pt;">
			<font style="display:inline;font-family:Arial,Helvetica,sans-serif;color:#2B2A29;">02 - Jonathan Hepple, Ph.D.</font>
		</p>
		<p style="margin:0pt 0pt 0pt 18pt;color:#2B2A29;font-family:Times New Roman,Times,serif;font-size: 10pt;">
			<font style="display:inline;font-family:Arial,Helvetica,sans-serif;color:#2B2A29;">2.&nbsp;&nbsp;&nbsp;&nbsp;RATIFICATION OF APPOINTMENT OF ERNST &amp; YOUNG LLP AS OUR INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM FOR FISCAL YEAR 2020</font>
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		<p style="margin:0pt 0pt 0pt 1pt;text-align:justify;text-justify:inter-ideograph;font-family:Times New Roman,Times,serif;font-size: 10pt;">
			<font style="display:inline;font-family:Arial,Helvetica,sans-serif;">&nbsp;</font>
		</p>
		<p style="margin:0pt 0pt 0pt 1pt;text-align:justify;text-justify:inter-ideograph;color:#2B2A29;font-family:Times New Roman,Times,serif;font-size: 10pt;">
			<font style="display:inline;font-family:Arial,Helvetica,sans-serif;color:#2B2A29;">PLEASE NOTE - THIS IS NOT A BALLOT. YOU CANNOT VOTE BY RETURNING THIS NOTICE. To vote your shares you must go online or request a paper copy of the proxy materials to receive a proxy card.</font>
		</p>
		<p style="margin:0pt 0pt 0pt 1pt;text-align:justify;text-justify:inter-ideograph;color:#2B2A29;font-family:Times New Roman,Times,serif;font-size: 10pt;">
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			<font style="display:inline;font-family:Arial,Helvetica,sans-serif;">&nbsp;</font>
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		<div style="width:100%;"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse:collapse;width: 100.00%;font-family:Times New Roman,Times,serif;">
			<tr>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;width:12.08%;background-color: #auto;padding:0pt;">
					<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 11pt;">
						<font style="display:inline;font-size:11pt;"><img src="tmb-20200429xdefa14ag005.jpg" style="width: 0.4686909in; height: 0.5728456in" alt="Picture 5"></font></p>
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					<p style="margin:0pt;color:#2B2A29;font-family:Times New Roman,Times,serif;font-size: 12pt;">
						<font style="display:inline;font-family:Arial,Helvetica,sans-serif;color:#2B2A29;font-size:12pt;">Here&#x2019;s how to order a copy of the proxy materials and select delivery preferences:</font></p>
					<p style="margin:0pt;color:#2B2A29;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Arial,Helvetica,sans-serif;">&nbsp;</font></p>
					<p style="margin:0pt;color:#2B2A29;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Arial,Helvetica,sans-serif;color:#2B2A29;">Current and future delivery requests can be submitted using the options below.</font></p>
					<p style="margin:0pt;color:#2B2A29;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Arial,Helvetica,sans-serif;">&nbsp;</font></p>
					<p style="margin:0pt;color:#2B2A29;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Arial,Helvetica,sans-serif;color:#2B2A29;">If you request an email copy, you will receive an email with a link to the current meeting materials.</font></p>
					<p style="margin:0pt;color:#2B2A29;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Arial,Helvetica,sans-serif;">&nbsp;</font></p>
					<p style="margin:0pt;color:#2B2A29;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Arial,Helvetica,sans-serif;color:#2B2A29;">PLEASE NOTE: You must use the number in the shaded bar on the reverse side when requesting a copy of the proxy materials.</font></p>
					<p style="margin:0pt;color:#2B2A29;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Arial,Helvetica,sans-serif;">&nbsp;</font></p>
					<p style="margin:0pt;color:#2B2A29;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Arial,Helvetica,sans-serif;color:#2B2A29;">&#x2014;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Internet - Go to www.envisionreports.com/APRE. Click Cast Your Vote or Request Materials. </font></p>
					<p style="margin:0pt;color:#2B2A29;font-family:Times New Roman,Times,serif;font-size: 10pt;">
						<font style="display:inline;font-family:Arial,Helvetica,sans-serif;">&nbsp;</font></p>
					<p style="margin:0pt;color:#2B2A29;font-family:Times New Roman,Times,serif;font-size: 10pt;">
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