    <SEC-DOCUMENT>0001104659-21-003257-index.html : 20210112
    <SEC-HEADER>0001104659-21-003257.hdr.sgml : 20210112
    <ACCEPTANCE-DATETIME>20210112080006
    ACCESSION NUMBER:		0001104659-21-003257
    CONFORMED SUBMISSION TYPE:	8-K
    PUBLIC DOCUMENT COUNT:		22
    CONFORMED PERIOD OF REPORT:	20210112
    ITEM INFORMATION:		Results of Operations and Financial Condition
    ITEM INFORMATION:		Regulation FD Disclosure
    ITEM INFORMATION:		Financial Statements and Exhibits
    FILED AS OF DATE:		20210112
    DATE AS OF CHANGE:		20210112

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Aprea Therapeutics, Inc.
    		CENTRAL INDEX KEY:			0001781983
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				000000000
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		8-K
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-39069
    		FILM NUMBER:		21522449

    	BUSINESS ADDRESS:
    		STREET 1:		535 BOYLSTON STREET
    		CITY:			BOSTON
    		STATE:			MA
    		ZIP:			02116
    		BUSINESS PHONE:		6095104718

    	MAIL ADDRESS:
    		STREET 1:		535 BOYLSTON STREET
    		CITY:			BOSTON
    		STATE:			MA
    		ZIP:			02116
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>8-K
    <SEQUENCE>1
    <FILENAME>tm212789d1_8k.htm
    <DESCRIPTION>FORM 8-K
    <TEXT>
    Document 1 - file: tm212789d1_8k.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-99.1
    <SEQUENCE>2
    <FILENAME>tm212789d1_ex99-1.htm
    <DESCRIPTION>EXHIBIT 99.1
    <TEXT>
    Document 2 - file: tm212789d1_ex99-1.htm

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>3
    <FILENAME>tm212789d1_ex99-1img001.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 3 - file: tm212789d1_ex99-1img001.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>4
    <FILENAME>tm212789d1_ex99-1img002.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 4 - file: tm212789d1_ex99-1img002.jpg

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    <SEQUENCE>5
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    <DESCRIPTION>GRAPHIC
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    Document 5 - file: tm212789d1_ex99-1img003.jpg

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    <DOCUMENT>
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    <SEQUENCE>6
    <FILENAME>tm212789d1_ex99-1img004.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 6 - file: tm212789d1_ex99-1img004.jpg

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    <DOCUMENT>
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    <SEQUENCE>7
    <FILENAME>tm212789d1_ex99-1img005.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 7 - file: tm212789d1_ex99-1img005.jpg

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    <SEQUENCE>8
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    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 8 - file: tm212789d1_ex99-1img006.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>9
    <FILENAME>tm212789d1_ex99-1img007.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 9 - file: tm212789d1_ex99-1img007.jpg

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    <DOCUMENT>
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    <SEQUENCE>10
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    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 10 - file: tm212789d1_ex99-1img008.jpg

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    <DOCUMENT>
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    <SEQUENCE>11
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    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 11 - file: tm212789d1_ex99-1img009.jpg

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    <DOCUMENT>
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    <SEQUENCE>12
    <FILENAME>tm212789d1_ex99-1img010.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 12 - file: tm212789d1_ex99-1img010.jpg

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    <DOCUMENT>
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    <SEQUENCE>13
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    Document 13 - file: tm212789d1_ex99-1img011.jpg

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    Document 14 - file: tm212789d1_ex99-1img012.jpg

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    <SEQUENCE>15
    <FILENAME>tm212789d1_ex99-1img013.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 15 - file: tm212789d1_ex99-1img013.jpg

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    <SEQUENCE>16
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    <TEXT>
    Document 16 - file: tm212789d1_ex99-1img014.jpg

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    <DOCUMENT>
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    <SEQUENCE>17
    <FILENAME>tm212789d1_ex99-1img015.jpg
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    <TEXT>
    Document 17 - file: tm212789d1_ex99-1img015.jpg

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    <SEQUENCE>18
    <FILENAME>tm212789d1_ex99-1img016.jpg
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    Document 18 - file: tm212789d1_ex99-1img016.jpg

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    <SEQUENCE>19
    <FILENAME>tm212789d1_ex99-1img017.jpg
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    Document 19 - file: tm212789d1_ex99-1img017.jpg

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    <SEQUENCE>20
    <FILENAME>tm212789d1_ex99-1img018.jpg
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    <TEXT>
    Document 20 - file: tm212789d1_ex99-1img018.jpg

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    <DOCUMENT>
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    <SEQUENCE>21
    <FILENAME>tm212789d1_ex99-1img019.jpg
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    Document 21 - file: tm212789d1_ex99-1img019.jpg

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    <SEQUENCE>22
    <FILENAME>tm212789d1_ex99-1img020.jpg
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    <TEXT>
    Document 22 - file: tm212789d1_ex99-1img020.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>