<SEC-DOCUMENT>0001140361-22-020779.txt : 20220526
<SEC-HEADER>0001140361-22-020779.hdr.sgml : 20220526
<ACCEPTANCE-DATETIME>20220526161533
ACCESSION NUMBER:		0001140361-22-020779
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20220516
FILED AS OF DATE:		20220526
DATE AS OF CHANGE:		20220526

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Duey Marc
		CENTRAL INDEX KEY:			0001925150

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-39069
		FILM NUMBER:		22970176

	MAIL ADDRESS:	
		STREET 1:		27 STRATHMORE ROAD
		CITY:			NATICK
		STATE:			MA
		ZIP:			01760

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Aprea Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001781983
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		535 BOYLSTON STREET
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116
		BUSINESS PHONE:		6095104718

	MAIL ADDRESS:	
		STREET 1:		535 BOYLSTON STREET
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>form3.xml
<DESCRIPTION>FORM 3
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<ownershipDocument>

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    <documentType>3</documentType>

    <periodOfReport>2022-05-16</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001781983</issuerCik>
        <issuerName>Aprea Therapeutics, Inc.</issuerName>
        <issuerTradingSymbol>APRE</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001925150</rptOwnerCik>
            <rptOwnerName>Duey Marc</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>535 BOYLSTON STREET</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>BOSTON</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02116</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>151904</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>439</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By spouse</value>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Stock Option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>0.44</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2022-05-16</value>
            </exerciseDate>
            <expirationDate>
                <value>2028-05-30</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>51154</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Series A Non-Voting Convertible Preferred Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F1"/>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F1"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>400969</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Series A Non-Voting Convertible Preferred Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F1"/>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F1"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>1161</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By spouse</value>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Following stockholder approval at the Issuer's annual stockholder's meeting, each share of Series A Non-Voting Convertible Preferred Stock is convertible into 10 shares of the Issuer's common stock (&quot;Common Stock&quot;) at any time at the option of the holder thereof, subject to certain limitations, including that a holder of Series A Non-Voting Convertible Preferred Stock is prohibited from converting shares of Series A Non-Voting Convertible Preferred Stock into shares of Common Stock if, as a result of such conversion, such holder, together with its affiliates, would beneficially own more than a specified percentage (to be established by the holder between 4.9% and 19.9%) of the total number of shares of Common Stock issued and outstanding immediately after giving effect to such conversion.  The Series A Non-Voting Convertible Preferred Stock has no expiration date.</footnote>
    </footnotes>

    <remarks>Exhibit 24 - Power of Attorney</remarks>

    <ownerSignature>
        <signatureName>/s/ Scott M. Coiante, attorney-in-fact</signatureName>
        <signatureDate>2022-05-26</signatureDate>
    </ownerSignature>
</ownershipDocument>
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<TYPE>EX-24
<SEQUENCE>2
<FILENAME>brhc10038049_ex24.htm
<DESCRIPTION>EXHIBIT 24
<TEXT>
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      <div style="text-align: right; color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Exhibit 24</div>
      <div style="font-family: 'Times New Roman'; font-size: 10pt;"><br>
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      <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">POWER OF ATTORNEY</div>
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      <div style="text-indent: 36pt; color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt;">Know all by these presents, that the undersigned hereby makes, constitutes and appoints each of Gregory A. Korbel and
        Scott M. Coiante, or either of them acting individually, and with full power of substitution, the undersigned's true and lawful attorney-in-fact to:</div>
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                  <div style="color: rgb(31, 31, 31);">(1)</div>
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                  <div style="text-align: left; color: rgb(31, 31, 31); text-indent: 0pt; margin-left: 9pt;">prepare, execute in the undersigned's name and on the undersigned's behalf, and submit to the U.S. Securities and Exchange Commission (the "SEC") a
                    Form ID, including amendments thereto, and any other documents necessary or appropriate to obtain codes and passwords enabling the undersigned to make electronic filings with the SEC of reports required by Section 16(a) of the
                    Securities Exchange Act of 1934 or any rule or regulation of the SEC;</div>
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        </font></div>
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                <div style="color: rgb(31, 31, 31);">(2)</div>
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                  <div style="text-indent: 0pt; margin-left: 9pt;"><font style="font-family: 'Times New Roman'; font-size: 10pt; color: rgb(31, 31, 31);">execute
                      for and on behalf of the undersigned, in the undersigned's capacity as an officer and/or director of </font><font style="font-family: 'Times New Roman'; font-size: 10pt; color: rgb(0, 0, 0);">Aprea Therapeutics, Inc. </font><font style="font-family: 'Times New Roman'; font-size: 10pt; color: rgb(31, 31, 31);">a Delaware corporation (the "Company"), Forms 3, 4, and 5, including amendments thereto, in accordance with Section 16(a) of the Securities
                      Exchange Act of 1934 and the rules and regulations thereunder;</font></div>
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                  <div style="color: rgb(31, 31, 31); text-indent: 0pt; margin-left: 9pt;">do and perform any and all acts for and on behalf of the undersigned which may be necessary or desirable to complete and execute any such Form 3,
                    4, or 5, complete and execute any amendment or amendments thereto, and timely file such form with the SEC and any stock exchange or similar authority; and</div>
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                <div style="text-align: left; color: rgb(31, 31, 31);">
                  <div style="color: rgb(31, 31, 31); text-indent: 0pt; margin-left: 9pt;">take any other action of any type whatsoever in connection with the foregoing which, in the opinion of such attorney-in-fact, may be of benefit to,
                    in the best interest of, or legally required by, the undersigned, it being understood that the documents executed by such attorney-in-fact on behalf of the undersigned pursuant to this Power of Attorney shall be in such form and shall
                    contain such terms and conditions as such attorney-in-fact may approve in such attorney-in-fact's discretion.</div>
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      <div style="text-indent: 36pt; color: rgb(31, 31, 31); font-family: 'Times New Roman'; font-size: 10pt;">The undersigned hereby grants to each such attorney-in-fact full power and authority to do and perform any and every
        act and thing whatsoever requisite, necessary, or proper to be done in the exercise of any of the rights and powers herein granted, as fully to all intents and purposes as the undersigned might or could do if personally present, with full power of
        substitution or revocation, hereby ratifying and confirming all that such attorney-in-fact, or such attorney-in-fact's substitute or substitutes, shall lawfully do or cause to be done by virtue of this power of attorney and the rights and powers
        herein granted. The undersigned acknowledges that the foregoing attorneys-in-fact, in serving in such capacity at the request of the undersigned, are not assuming, nor is the Company assuming, any of the undersigned's responsibilities to comply
        with Section 16 of the Securities Exchange Act of 1934.</div>
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      <div style="text-indent: 36pt; font-family: 'Times New Roman', serif; font-size: 11pt;"><font style="font-family: 'Times New Roman'; font-size: 10pt; color: rgb(31, 31, 31);">This Power of Attorney shall remain in full
          force and effect until the undersigned is no longer required to file Forms 3, 4, and 5 with respect to the undersigned's holdings of and transactions in securities issued by the Company, unless earlier (a) revoked by the undersigned </font><font style="font-family: 'Times New Roman'; font-size: 10pt; color: rgb(63, 63, 63);">i</font><font style="font-family: 'Times New Roman'; font-size: 10pt; color: rgb(31, 31, 31);">n a signed writing delivered to the foregoing
          attorneys-in-fact or (b) superseded by a new power of attorney regarding the purposes outlined herein at a later date.</font></div>
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      <div style="text-indent: 36pt; font-family: 'Times New Roman', serif; font-size: 11pt;"><font style="font-family: 'Times New Roman'; font-size: 10pt; color: rgb(0, 0, 0);">IN WITNESS WHEREOF, the undersigned has caused
          this Power of Attorney to be executed as of this 26th </font><font style="font-family: 'Times New Roman'; font-size: 10pt; color: rgb(31, 31, 31);">day of May</font><font style="font-family: 'Times New Roman'; font-size: 10pt; color: rgb(0, 0, 0);">,</font><font style="font-family: 'Times New Roman'; font-size: 10pt; color: rgb(31, 31, 31);"> 2022.</font></div>
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              <div style="color: rgb(0, 0, 0);">/s/ Marc Duey</div>
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              <div style="color: rgb(0, 0, 0);">Marc Duey</div>
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