<SEC-DOCUMENT>0001104659-22-068116-index.html : 20220603
<SEC-HEADER>0001104659-22-068116.hdr.sgml : 20220603
<ACCEPTANCE-DATETIME>20220603163158
ACCESSION NUMBER:		0001104659-22-068116
CONFORMED SUBMISSION TYPE:	S-8
PUBLIC DOCUMENT COUNT:		8
FILED AS OF DATE:		20220603
DATE AS OF CHANGE:		20220603
EFFECTIVENESS DATE:		20220603

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Aprea Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001781983
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-8
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-265411
		FILM NUMBER:		22995012

	BUSINESS ADDRESS:	
		STREET 1:		535 BOYLSTON STREET
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116
		BUSINESS PHONE:		6095104718

	MAIL ADDRESS:	
		STREET 1:		535 BOYLSTON STREET
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-8
<SEQUENCE>1
<FILENAME>tm2217601d1_s8.htm
<DESCRIPTION>FORM S-8
<TEXT>
Document 1 - file: tm2217601d1_s8.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-4.3
<SEQUENCE>2
<FILENAME>tm2217601d1_ex4-3.htm
<DESCRIPTION>EXHIBIT 4.3
<TEXT>
Document 2 - file: tm2217601d1_ex4-3.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-4.4
<SEQUENCE>3
<FILENAME>tm2217601d1_ex4-4.htm
<DESCRIPTION>EXHIBIT 4.4
<TEXT>
Document 3 - file: tm2217601d1_ex4-4.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>4
<FILENAME>tm2217601d1_ex5-1.htm
<DESCRIPTION>EXHIBIT 5.1
<TEXT>
Document 4 - file: tm2217601d1_ex5-1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.2
<SEQUENCE>5
<FILENAME>tm2217601d1_ex23-2.htm
<DESCRIPTION>EXHIBIT 23.2
<TEXT>
Document 5 - file: tm2217601d1_ex23-2.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-FILING FEES
<SEQUENCE>6
<FILENAME>tm2217601d1_ex-fillingfees.htm
<DESCRIPTION>EX-FILING FEES
<TEXT>
Document 6 - file: tm2217601d1_ex-fillingfees.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>7
<FILENAME>tm2217601d1_ex5-1img001.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 7 - file: tm2217601d1_ex5-1img001.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>8
<FILENAME>tm2217601d1_ex5-1img002.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 8 - file: tm2217601d1_ex5-1img002.jpg

</DOCUMENT>
</SEC-DOCUMENT>