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Consolidated Statements of Convertible Preferred Stock and Stockholders' Equity (Deficit) - USD ($) | Series A Convertible Preferred Stock | Common Stock | Additional Paid-in capital | Other comprehensive loss | Accumulated deficit | Total
--- | --- | --- | --- | --- | --- | ---
Equity, beginning balance at Dec. 31, 2019 |  | $ 1,051 | $ 226,304,519 | $ (11,533,778) | $ (90,528,263) | $ 124,243,530
Equity, beginning balance (in shares) at Dec. 31, 2019 |  | 1,051,137 |  |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |
Exercise of stock options |  | $ 8 | 150,941 |  |  | 150,949
Exercise of stock options (in shares) |  | 8,203 |  |  |  |
Stock based compensation |  |  | 4,983,023 |  |  | 4,983,023
Foreign currency translation |  |  |  | 1,496,517 |  | 1,496,517
Net loss |  |  |  |  | (53,478,812) | (53,478,812)
Equity, ending balance at Dec. 31, 2020 |  | $ 1,059 | 231,438,483 | (10,037,261) | (144,007,075) | 77,395,207
Equity, ending balance (in shares) at Dec. 31, 2020 |  | 1,059,340 |  |  |  |
Temporary equity, ending balance (in shares) at Dec. 31, 2021 | 0 |  |  |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |
Issuance of common stock pursuant to at-the-market stock sales, net |  | $ 18 | 1,538,627 |  |  | 1,538,645
Issuance of common stock pursuant to at-the-market stock sales, net (in shares) |  | 18,338 |  |  |  |
Exercise of stock options |  | $ 11 | 208,356 |  |  | 208,367
Exercise of stock options (in shares) |  | 11,319 |  |  |  |
Vesting of restricted stock units |  | $ 4 | (4) |  |  |
Vesting of restricted stock units (in shares) |  | 3,970 |  |  |  |
Stock based compensation |  |  | 7,813,743 |  |  | 7,813,743
Foreign currency translation |  |  |  | (321,695) |  | (321,695)
Net loss |  |  |  |  | (37,127,303) | (37,127,303)
Equity, ending balance at Dec. 31, 2021 |  | $ 1,092 | 240,999,206 | (10,358,956) | (181,134,378) | 49,506,964
Equity, ending balance (in shares) at Dec. 31, 2021 |  | 1,092,967 |  |  |  |
Increase (Decrease) in Temporary Equity |  |  |  |  |  |
Issuance of preferred stock upon acquisition of Atrin | $ 68,777,468 |  |  |  |  |
Issuance of preferred stock upon acquisition of Atrin (in shares) | 2,949,630 |  |  |  |  |
Conversion of preferred stock into common stock | $ (67,466,405) |  |  |  |  |
Conversion of preferred stock into common stock (in shares) | (2,893,403) |  |  |  |  |
Temporary equity, ending balance (in shares) at Dec. 31, 2022 | 56,227 |  |  |  |  |
Temporary equity, ending balance at Dec. 31, 2022 | $ 1,311,063 |  |  |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |
Issuance of common stock pursuant to at-the-market stock sales, net |  | $ 39 | 682,934 |  |  | 682,973
Issuance of common stock pursuant to at-the-market stock sales, net (in shares) |  | 38,481 |  |  |  |
Issuance of stock upon acquisition of Atrin |  | $ 56 | 1,329,643 |  |  | 1,329,699
Issuance of stock upon acquisition of Atrin (in shares) |  | 55,869 |  |  |  |
Value of assumed stock options |  |  | 2,602,850 |  |  | 2,602,850
Vesting of restricted stock units |  | $ 21 | (21) |  |  |
Vesting of restricted stock units (in shares) |  | 21,251 |  |  |  |
Stock based compensation |  |  | 16,981,266 |  |  | 16,981,266
Foreign currency translation |  |  |  | (264,452) |  | (264,452)
Conversion of preferred stock into common stock |  | $ 1,447 | 67,464,958 |  |  | 67,466,405
Conversion of preferred stock into common stock (in shares) |  | 1,446,701 |  |  |  |
Net loss |  |  |  |  | (112,662,027) | (112,662,027)
Equity, ending balance at Dec. 31, 2022 |  | $ 2,655 | $ 330,060,836 | $ (10,623,408) | $ (293,796,405) | $ 25,643,678
Equity, ending balance (in shares) at Dec. 31, 2022 |  | 2,655,269 |  |  |  |

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