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Income taxes (Tables) | 12 Months Ended
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Dec. 31, 2022
Income taxes |
Schedule of components of income taxes | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Year ended December 31, | ​
​ | ​ | 2022 | ​ | 2021 | ​ | 2020 |
Foreign |  | $ | (6,377,901) |  | $ | (13,229,828) |  | $ | (27,215,385) | ​
Domestic | ​ |  | (106,284,126) | ​ |  | (23,897,475) | ​ |  | (26,263,427) | ​
Net loss | ​ | $ | (112,662,027) | ​ | $ | (37,127,303) | ​ | $ | (53,478,812) | ​
​
Summary of reconciliation of the effect of applying federal statutory rate to the net loss and the effective income tax rate | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Year ended December 31, |
​ | ​ | 2022 | ​ | 2021 | ​ | 2020 |
Statutory federal income tax rate |  | 21.0 | % | 21.0 | % | 21.0 | %
Earnings in jurisdictions taxed at rates different from the statutory U.S. federal tax rate |  | — | % | (0.1) | % | 0.2 | %
Permanent differences |  | (0.6) | % | — | % | 1.7 | %
Section 162(m) limitation | ​ | (2.5) | % | — | % | — | %
In-process research and development | ​ | (13.5) | % | — | % | — | %
Changes in valuation allowance |  | (3.7) | % | (18.2) | % | (22.5) | %
Other |  | (0.7) | % | (2.7) | % | (0.4) | %
Effective income tax rate |  | — | % | — | % | — | %
​
Summary of significant components of deferred taxes | ​
​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | December 31,
​ | ​ | 2022 | ​ | 2021
Deferred tax assets: |  | ​ |  |  | ​ |
Net operating loss carryforward | ​ | $ | 38,839,281 | ​ | $ | 38,773,870
Stock compensation | ​ | ​ | 2,309,828 | ​ | ​ | 3,341,338
Amortization | ​ | ​ | 118,259 | ​ | ​ | —
Capitalized R&D costs | ​ | ​ | 2,362,347 | ​ | ​ | ​
Lease liability | ​ | ​ | — | ​ | ​ | 47,677
Gross deferred tax assets | ​ |  | 43,629,715 | ​ |  | 42,162,885
Valuation allowance | ​ |  | (43,629,689) | ​ |  | (42,115,543)
Total deferred tax assets | ​ |  | 26 | ​ |  | 47,342
Deferred tax liabilities: | ​ |  | ​ | ​ |  | ​
Fixed assets | ​ |  | (26) | ​ |  | (818)
Right of use asset | ​ | ​ | — | ​ | ​ | (46,524)
Total deferred tax liabilities | ​ |  | (26) | ​ |  | (47,342)
Net deferred tax assets (liabilities) | ​ | $ | — | ​ | $ | —
​

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- Definition Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 2 -URI https://asc.fasb.org/extlink&oid=121826272&loc=d3e32537-109319 + Details
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- Definition Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 12 -URI https://asc.fasb.org/extlink&oid=121826272&loc=d3e32687-109319 + Details
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- Definition Tabular disclosure of income before income tax between domestic and foreign jurisdictions. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 235 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.4-08(h)(1)(Note 1)) -URI https://asc.fasb.org/extlink&oid=120395691&loc=d3e23780-122690 + Details
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