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Stock option plans - Stock option activity (Details) - 2019 Equity Incentive Plan - $ / shares | 12 Months Ended
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Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Number of options |  |  |  |
Outstanding, beginning of period | 229,308 | 188,552 | 174,975 |
Granted | 96,798 | 58,980 | 22,340 |
Options assumed in Atrin merger | 163,733 |  |  |
Exercised |  | (11,319) | (8,203) |
Cancelled/Forfeited | (9,565) | (6,905) | (560) |
Outstanding, end of period | 480,274 | 229,308 | 188,552 | 174,975
Exercisable | 447,721 |  |  |
Vested or expected to vest | 480,274 |  |  |
Weighted average exercise price per share |  |  |  |
Outstanding, beginning of period (in dollars per share) | $ 169.00 | $ 182.00 | $ 109.80 |
Granted (in dollars per share) | 31.40 | 117.40 | 710.13 |
Options assumed in Atrin merger (in dollars per share) | 14.21 |  |  |
Exercised (in dollars per share) |  | 18.40 | 18.33 |
Cancelled/Forfeited (in dollars per share) | 118.60 | 330.60 | 775.60 |
Outstanding, end of period (in dollars per share) | 89.49 | $ 169.00 | $ 182.00 | $ 109.80
Exercisable (in dollars per share) | 94.41 |  |  |
Vested or expected to vest (in dollars per share) | $ 89.49 |  |  |
Weighted average remaining contractual term (in years) |  |  |  |
Outstanding | 6 years 9 months 18 days | 6 years 7 months 6 days | 6 years 9 months 18 days | 7 years 6 months
Exercisable | 6 years 1 month 6 days |  |  |
Vested or expected to vest | 6 years 9 months 18 days |  |  |
Additional Disclosures |  |  |  |
Weighted average grant date fair value of options granted | $ 23.68 | $ 85.82 | $ 484.02 |

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- Definition The number of shares into which fully or partially vested stock options outstanding as of the balance sheet date can be currently converted under the option plan. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1)(iii) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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- Definition For presentations that combine terminations, the number of shares under options that were cancelled during the reporting period as a result of occurrence of a terminating event specified in contractual agreements pertaining to the stock option plan or that expired. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1)(iv) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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- Definition The addition or reduction in the number of reserved shares that could potentially be issued under the option plan attributable to reasons other than grants, exercises, forfeitures, and expirations during the reporting period. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1)(iv) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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- Definition Number of fully vested and expected to vest options outstanding that can be converted into shares under option plan. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (e)(1) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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