XML 36 R24.htm IDEA: XBRL DOCUMENT
v3.24.3

Stockholders' equity (Details) |  |  | 1 Months Ended | 3 Months Ended | 9 Months Ended |  |
--- | --- | --- | --- | --- | --- | --- | ---
Mar. 11, 2024 USD ($) $ / shares shares | Nov. 12, 2020 USD ($) | Feb. 28, 2023 USD ($) $ / shares shares | Sep. 30, 2024 USD ($) $ / shares shares | Sep. 30, 2023 USD ($) | Sep. 30, 2024 USD ($) Vote $ / shares shares | Sep. 30, 2023 USD ($) shares | Jan. 26, 2024 USD ($) | Dec. 31, 2023 $ / shares shares
Common stock |  |  |  |  |  |  |  |  |
Stock, shares authorized | shares |  |  |  | 440,000,000 |  | 440,000,000 |  |  |
Common stock, shares authorized | shares |  |  |  | 400,000,000 |  | 400,000,000 |  |  | 400,000,000
Common stock, par value (in dollars per share) | $ / shares |  |  |  | $ 0.001 |  | $ 0.001 |  |  | $ 0.001
Preferred stock, shares authorized | shares |  |  |  | 40,000,000 |  | 40,000,000 |  |  |
Preferred stock, par value (in dollars per share) | $ / shares |  |  |  | $ 0.001 |  | $ 0.001 |  |  |
Common stock issuable upon conversion (in shares) | shares |  |  |  | 28,112 |  | 28,112 |  |  |
Number of voting rights per common share | Vote |  |  |  |  |  | 1 |  |  |
Stock based compensation expense |  |  |  | $ 149,090 | $ 76,031 | $ 363,408 | $ 361,598 |  |
Shelf Registration Statement |  |  |  |  |  |  |  |  |
Proceeds from issuance of common stock |  |  |  |  |  | 15,999,598 | 5,788,918 |  |
Common stock issuance costs |  |  |  |  |  | 1,312,108 | $ 648,928 |  |
March 2024 Private Placement |  |  |  |  |  |  |  |  |
Warrant exercises |  |  |  |  |  | $ 0 |  |  |
Series A Convertible Preferred Stock |  |  |  |  |  |  |  |  |
Common stock |  |  |  |  |  |  |  |  |
Convertible preferred stock, shares outstanding | shares |  |  |  | 56,227 |  | 56,227 |  |  | 56,227
March 2024 Private Placement | Pre-funded Warrants |  |  |  |  |  |  |  |  |
March 2024 Private Placement |  |  |  |  |  |  |  |  |
Warrants to purchase of shares | shares |  |  |  | 507,076 |  | 507,076 |  |  |
March 2024 Private Placement | Purchasers | Securities purchase agreement |  |  |  |  |  |  |  |  |
Shelf Registration Statement |  |  |  |  |  |  |  |  |
Shares issued | shares | 1,687,712 |  |  |  |  |  |  |  |
Common stock issuance costs | $ 1,300,000 |  |  |  |  |  |  |  |
March 2024 Private Placement |  |  |  |  |  |  |  |  |
Offering price per share | $ / shares | $ 7.29 |  |  |  |  |  |  |  |
Common stock with an exercise price | $ / shares | $ 0.001 |  |  |  |  |  |  |  |
Percentage of outstanding shares | 4.99% |  |  |  |  |  |  |  |
Proceeds from sale of common stock in a private placement | $ 16,000,000.0 |  |  |  |  |  |  |  |
Expected gross proceeds from potential future warrants cash exercise | $ 18,000,000.0 |  |  |  |  |  |  |  |
March 2024 Private Placement | Purchasers | Securities purchase agreement | At the election of holder |  |  |  |  |  |  |  |  |
March 2024 Private Placement |  |  |  |  |  |  |  |  |
Percentage of outstanding shares | 9.99% |  |  |  |  |  |  |  |
March 2024 Private Placement | Purchasers | Securities purchase agreement | Pre-funded Warrants |  |  |  |  |  |  |  |  |
March 2024 Private Placement |  |  |  |  |  |  |  |  |
Offering price per share | $ / shares | $ 7.289 |  |  |  |  |  |  |  |
Warrants to purchase of shares | shares | 507,076 |  |  |  |  |  |  |  |
March 2024 Private Placement | Purchasers | Securities purchase agreement | Tranche A Warrants (Pre-funded Warrants Exercise Price 7.29 Per Share) |  |  |  |  |  |  |  |  |
March 2024 Private Placement |  |  |  |  |  |  |  |  |
Warrants to purchase of shares | shares | 1,097,394 |  |  |  |  |  |  |  |
Common stock with an exercise price | $ / shares | $ 7.29 |  |  |  |  |  |  |  |
Stock issuance anniversary period | 3 years |  |  |  |  |  |  |  |
Number of days after announcement of Phase 2 dose for ATRN-119 | 30 days |  |  |  |  |  |  |  |
Volume weighted average price | $ / shares | $ 14.58 |  |  |  |  |  |  |  |
Number of consecutive trading days | 30 days |  |  |  |  |  |  |  |
March 2024 Private Placement | Purchasers | Securities purchase agreement | Tranche B Warrants (Pre-funded Warrants Exercise Price 9.1125 Per Share) |  |  |  |  |  |  |  |  |
March 2024 Private Placement |  |  |  |  |  |  |  |  |
Common stock with an exercise price | $ / shares | $ 9.1125 |  |  |  |  |  |  |  |
Stock issuance anniversary period | 5 years |  |  |  |  |  |  |  |
Number of days after announcement of Phase 2 dose for ATRN-119 | 30 days |  |  |  |  |  |  |  |
Volume weighted average price | $ / shares | $ 18.225 |  |  |  |  |  |  |  |
2020 Shelf Registration Statement |  |  |  |  |  |  |  |  |
Shelf Registration Statement |  |  |  |  |  |  |  |  |
Maximum amount to be issued under universal shelf registration statement |  | $ 350,000,000.0 |  |  |  |  |  |  |
2020 Shelf Registration Statement | Common Stock |  |  |  |  |  |  |  |  |
Shelf Registration Statement |  |  |  |  |  |  |  |  |
Shares issued | shares |  |  | 1,050,000 |  |  |  |  |  |
Issue price per share | $ / shares |  |  | $ 5.25 |  |  |  |  |  |
Proceeds from issuance of common stock |  |  | $ 4,900,000 |  |  |  |  |  |
Common stock issuance costs |  |  | $ 600,000 |  |  |  |  |  |
ATM offering |  |  |  |  |  |  |  |  |
Common stock |  |  |  |  |  |  |  |  |
Commission payable as a percentage of gross proceeds from sale of common stock under ATM offering |  | 3.00% |  |  |  |  |  |  |
Shelf Registration Statement |  |  |  |  |  |  |  |  |
Maximum amount to be issued under at-the-market offering program |  | $ 14,744,728 |  |  |  |  |  |  |
Shares issued | shares |  |  |  |  |  |  | 26,302 |  |
Proceeds from issuance of common shares |  |  |  |  |  |  | $ 300,000 |  |
Common stock issuance costs |  |  |  |  |  |  | $ 8,000 |  |
2024 Shelf Registration Statement |  |  |  |  |  |  |  |  |
Shelf Registration Statement |  |  |  |  |  |  |  |  |
Maximum amount to be issued under universal shelf registration statement |  |  |  |  |  |  |  | $ 150,000,000 |
Maximum amount to be issued under at-the-market offering program |  |  |  |  |  |  |  | 1,000,000 |
Maximum amount to be issued under at-the-market offering program, supplement |  |  |  |  |  |  |  | 2,000,000 |
2024 ATM offering | HCW |  |  |  |  |  |  |  |  |
Shelf Registration Statement |  |  |  |  |  |  |  |  |
Maximum amount to be issued under at-the-market offering program |  |  |  |  |  |  |  | $ 2,000,000 |

X
- Definition Represents the commission payable as a percentage of gross proceeds from sale of common stock under the at-the market offering. + References No definition available. + Details
Name: | apre_AtMarketOfferingCommissionPayableAsPercentageOfGrossProceedsFromSaleOfCommonStock
Namespace Prefix: | apre_
Data Type: | dtr-types:percentItemType
Balance Type: | na
Period Type: | duration

X
- Definition Maximum amount of common stock to be issued under an at-the-market offering program + References No definition available. + Details
Name: | apre_AtMarketOfferingProgramMaximumAmountToBeIssued
Namespace Prefix: | apre_
Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | instant

X
- Definition Maximum amount of common stock to be issued under a supplemental at-the-market offering program. + References No definition available. + Details
Name: | apre_AtMarketOfferingProgramMaximumAmountToBeIssuedSupplement
Namespace Prefix: | apre_
Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | instant

X
- Definition Number of voting rights per share of common stock owned. + References No definition available. + Details
Name: | apre_CommonStockNumberOfVotingRightsPerShare
Namespace Prefix: | apre_
Data Type: | xbrli:integerItemType
Balance Type: | na
Period Type: | duration

X
- Definition The expected gross proceeds from potential future warrant cash exercises. + References No definition available. + Details
Name: | apre_ExpectedGrossProceedsFromPotentialFutureWarrantCashExercise
Namespace Prefix: | apre_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration

X
- Definition Number of consecutive trading days. + References No definition available. + Details
Name: | apre_NumberOfConsecutiveTradingDays
Namespace Prefix: | apre_
Data Type: | xbrli:durationItemType
Balance Type: | na
Period Type: | duration

X
- Definition Number of days after the Company announces the recommended Phase 2 dose for ATRN-119. + References No definition available. + Details
Name: | apre_NumberOfDaysAfterCompanyAnnouncesRecommendedPhase2DoseForAtrn119
Namespace Prefix: | apre_
Data Type: | xbrli:durationItemType
Balance Type: | na
Period Type: | duration

X
- Definition Represents the percentage of outstanding shares. + References No definition available. + Details
Name: | apre_PercentageOfOutstandingShares
Namespace Prefix: | apre_
Data Type: | dtr-types:percentItemType
Balance Type: | na
Period Type: | instant

X
- References No definition available. + Details
Name: | apre_PrivatePlacementAbstract
Namespace Prefix: | apre_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration

X
- Definition Volume weighted average price per share of common stock after announcement of recommended Phase 2 dose for ATRN-119. + References No definition available. + Details
Name: | apre_SharesIssuedVolumeWeightedAveragePricePerShare
Namespace Prefix: | apre_
Data Type: | dtr-types:perShareItemType
Balance Type: | na
Period Type: | instant

X
- References No definition available. + Details
Name: | apre_ShelfRegistrationStatementAbstract
Namespace Prefix: | apre_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration

X
- Definition Period of anniversary of issuance of common stock. + References No definition available. + Details
Name: | apre_StockIssuanceAnniversaryPeriod
Namespace Prefix: | apre_
Data Type: | xbrli:durationItemType
Balance Type: | na
Period Type: | duration

X
- Definition The maximum number of shares permitted to be issued by an entity's charter and bylaws. + References No definition available. + Details
Name: | apre_StockSharesAuthorized
Namespace Prefix: | apre_
Data Type: | xbrli:sharesItemType
Balance Type: | na
Period Type: | instant

X
- Definition Maximum amount of common stock, preferred stock, warrants, rights and debt securities and units that can be issued under a universal shelf registration statement. + References No definition available. + Details
Name: | apre_UniversalShelfRegistrationMaximumAmountToBeIssued
Namespace Prefix: | apre_
Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | instant

X
- Definition Amount of expense for award under share-based payment arrangement. Excludes amount capitalized. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 14.F) -Publisher FASB -URI https://asc.fasb.org/1943274/2147479830/718-10-S99-1 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (h)(1)(i) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
Name: | us-gaap_AllocatedShareBasedCompensationExpense
Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration

X
- Definition Exercise price per share or per unit of warrants or rights outstanding. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 505 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 3 -Publisher FASB -URI https://asc.fasb.org/1943274/2147481112/505-10-50-3 + Details
Name: | us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1
Namespace Prefix: | us-gaap_
Data Type: | dtr-types:perShareItemType
Balance Type: | na
Period Type: | instant

X
- Definition Number of securities into which the class of warrant or right may be converted. For example, but not limited to, 500,000 warrants may be converted into 1,000,000 shares. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 505 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 3 -Publisher FASB -URI https://asc.fasb.org/1943274/2147481112/505-10-50-3 + Details
Name: | us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights
Namespace Prefix: | us-gaap_
Data Type: | xbrli:sharesItemType
Balance Type: | na
Period Type: | instant

X
- Definition Face amount or stated value per share of common stock. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 210 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02(29)) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480566/210-10-S99-1 + Details
Name: | us-gaap_CommonStockParOrStatedValuePerShare
Namespace Prefix: | us-gaap_
Data Type: | dtr-types:perShareItemType
Balance Type: | na
Period Type: | instant

X
- Definition The maximum number of common shares permitted to be issued by an entity's charter and bylaws. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 210 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02(29)) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480566/210-10-S99-1 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 946 -SubTopic 210 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SX 210.6-04(16)(a)) -Publisher FASB -URI https://asc.fasb.org/1943274/2147479170/946-210-S99-1 + Details
Name: | us-gaap_CommonStockSharesAuthorized
Namespace Prefix: | us-gaap_
Data Type: | xbrli:sharesItemType
Balance Type: | na
Period Type: | instant

X
- Definition The cash outflow for cost incurred directly with the issuance of an equity security. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482740/230-10-45-15 + Details
Name: | us-gaap_PaymentsOfStockIssuanceCosts
Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | duration

X
- Definition Number of common shares issuable upon conversion of preferred stock. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 505 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 13 -Subparagraph (c) -Publisher FASB -URI https://asc.fasb.org/1943274/2147481112/505-10-50-13 + Details
Name: | us-gaap_PreferredStockConvertibleSharesIssuable
Namespace Prefix: | us-gaap_
Data Type: | xbrli:sharesItemType
Balance Type: | na
Period Type: | instant

X
- Definition Face amount or stated value per share of preferred stock nonredeemable or redeemable solely at the option of the issuer. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 210 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02(28)) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480566/210-10-S99-1 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 505 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 13 -Subparagraph (a) -Publisher FASB -URI https://asc.fasb.org/1943274/2147481112/505-10-50-13 + Details
Name: | us-gaap_PreferredStockParOrStatedValuePerShare
Namespace Prefix: | us-gaap_
Data Type: | dtr-types:perShareItemType
Balance Type: | na
Period Type: | instant

X
- Definition The maximum number of nonredeemable preferred shares (or preferred stock redeemable solely at the option of the issuer) permitted to be issued by an entity's charter and bylaws. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 210 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02(28)) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480566/210-10-S99-1 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 946 -SubTopic 210 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SX 210.6-04(16)(a)) -Publisher FASB -URI https://asc.fasb.org/1943274/2147479170/946-210-S99-1 + Details
Name: | us-gaap_PreferredStockSharesAuthorized
Namespace Prefix: | us-gaap_
Data Type: | xbrli:sharesItemType
Balance Type: | na
Period Type: | instant

X
- Definition The cash inflow from the additional capital contribution to the entity. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 45 -Paragraph 14 -Subparagraph (a) -SubTopic 10 -Topic 230 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482740/230-10-45-14 + Details
Name: | us-gaap_ProceedsFromIssuanceOfCommonStock
Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration

X
- Definition The cash inflow from the issuance of common stock, preferred stock, treasury stock, stock options, and other types of equity. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 45 -Paragraph 14 -Subparagraph (a) -SubTopic 10 -Topic 230 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482740/230-10-45-14 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 946 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 3 -Subparagraph (SX 210.6-03(i)(1)) -Publisher FASB -URI https://asc.fasb.org/1943274/2147479886/946-10-S99-3 + Details
Name: | us-gaap_ProceedsFromIssuanceOrSaleOfEquity
Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration

X
- Definition The cash inflow associated with the amount received from holders exercising their stock warrants. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 230 -SubTopic 10 -Name Accounting Standards Codification -Section 45 -Paragraph 14 -Subparagraph (a) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482740/230-10-45-14 + Details
Name: | us-gaap_ProceedsFromWarrantExercises
Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration

X
- Definition Cash received on stock transaction after deduction of issuance costs. + References No definition available. + Details
Name: | us-gaap_SaleOfStockConsiderationReceivedOnTransaction
Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration

X
- Definition Per share amount received by subsidiary or equity investee for each share of common stock issued or sold in the stock transaction. + References No definition available. + Details
Name: | us-gaap_SaleOfStockPricePerShare
Namespace Prefix: | us-gaap_
Data Type: | dtr-types:perShareItemType
Balance Type: | na
Period Type: | instant

X
- Definition Per share or per unit amount of equity securities issued. + References No definition available. + Details
Name: | us-gaap_SharesIssuedPricePerShare
Namespace Prefix: | us-gaap_
Data Type: | dtr-types:perShareItemType
Balance Type: | na
Period Type: | instant

X
- Definition Number of new stock issued during the period. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 2 -SubTopic 10 -Topic 505 -Publisher FASB -URI https://asc.fasb.org/1943274/2147481112/505-10-50-2 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 210 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02(28)) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480566/210-10-S99-1 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 210 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02(29)) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480566/210-10-S99-1 Reference 4: http://www.xbrl.org/2003/role/disclosureRef -Topic 946 -SubTopic 505 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (a) -Publisher FASB -URI https://asc.fasb.org/1943274/2147478448/946-505-50-2 Reference 5: http://www.xbrl.org/2003/role/disclosureRef -Topic 946 -SubTopic 220 -Name Accounting Standards Codification -Section S99 -Paragraph 3 -Subparagraph (SX 210.6-09(4)(b)) -Publisher FASB -URI https://asc.fasb.org/1943274/2147479134/946-220-S99-3 Reference 6: http://www.xbrl.org/2003/role/disclosureRef -Topic 946 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 3 -Subparagraph (SX 210.6-03(i)(1)) -Publisher FASB -URI https://asc.fasb.org/1943274/2147479886/946-10-S99-3 Reference 7: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 505 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SX 210.3-04) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480008/505-10-S99-1 + Details
Name: | us-gaap_StockIssuedDuringPeriodSharesNewIssues
Namespace Prefix: | us-gaap_
Data Type: | xbrli:sharesItemType
Balance Type: | na
Period Type: | duration

X
- Definition Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. + References No definition available. + Details
Name: | us-gaap_SubsidiarySaleOfStockLineItems
Namespace Prefix: | us-gaap_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration

X
- Definition The number of securities classified as temporary equity that have been issued and are held by the entity's shareholders. Securities outstanding equals securities issued minus securities held in treasury. Temporary equity is a security with redemption features that are outside the control of the issuer, is not classified as an asset or liability in conformity with GAAP, and is not mandatorily redeemable. Includes any type of security that is redeemable at a fixed or determinable price or on a fixed or determinable date or dates, is redeemable at the option of the holder, or has conditions for redemption which are not solely within the control of the issuer. If convertible, the issuer does not control the actions or events necessary to issue the maximum number of shares that could be required to be delivered under the conversion option if the holder exercises the option to convert the stock to another class of equity. If the security is a warrant or a rights issue, the warrant or rights issue is considered to be temporary equity if the issuer cannot demonstrate that it would be able to deliver upon the exercise of the option by the holder in all cases. Includes stock with put option held by ESOP and stock redeemable by holder only in the event of a change in control of the issuer. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 210 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02(27)(b)) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480566/210-10-S99-1 + Details
Name: | us-gaap_TemporaryEquitySharesOutstanding
Namespace Prefix: | us-gaap_
Data Type: | xbrli:sharesItemType
Balance Type: | na
Period Type: | instant

X
- Details
Name: | us-gaap_StatementClassOfStockAxis=apre_ConvertiblePreferredStockSeriesaMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | us-gaap_SubsidiarySaleOfStockAxis=us-gaap_PrivatePlacementMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | us-gaap_ClassOfWarrantOrRightAxis=apre_PreFundedWarrantsMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | srt_CounterpartyNameAxis=apre_CertainPurchasersMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | us-gaap_TypeOfArrangementAxis=apre_SecuritiesPurchaseAgreementMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | srt_StatementScenarioAxis=apre_AtEventOfElectionOfHolderMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | us-gaap_ClassOfWarrantOrRightAxis=apre_PreFundedWarrantsExercisePrice7.29PerShareMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | us-gaap_ClassOfWarrantOrRightAxis=apre_PreFundedWarrantsExercisePrice9.1125PerShareMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | us-gaap_SubsidiarySaleOfStockAxis=apre_ShelfRegistrationStatementMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | us-gaap_StatementClassOfStockAxis=us-gaap_CommonStockMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | us-gaap_SubsidiarySaleOfStockAxis=apre_AtMarketOfferingMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | us-gaap_SubsidiarySaleOfStockAxis=apre_ShelfRegistrationStatement2024Member
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | us-gaap_SubsidiarySaleOfStockAxis=apre_AtMarket2024OfferingMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | srt_CounterpartyNameAxis=apre_HCWainrightCoLlcMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |