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Note 6 - Equity Incentive Plans (Details Textual) |  |  | 1 Months Ended | 3 Months Ended | 12 Months Ended
--- | --- | --- | --- | --- | ---
Aug. 07, 2023 shares | Feb. 06, 2023 Days $ / shares shares | Apr. 30, 2021 USD ($) shares | Jun. 30, 2024 USD ($) | Dec. 31, 2024 USD ($) $ / shares shares | Dec. 31, 2023 USD ($) $ / shares shares
Number of options, Granted (in shares) |  |  |  |  | 12,300 |
Maximum shares issued under ESPP | $ |  |  |  |  | $ 11,000 | $ 17,000
Weighted-average grant date fair value of options granted | $ / shares |  |  |  |  | $ 3.8 | $ 12.33
Unrecognized compensation cost weighted-average period of recognition |  |  |  |  | 1 year 5 months 26 days |
Unrecognized compensation cost related to outstanding options | $ |  |  |  |  | $ 200,000 |
Grant date fair value of the options vested | $ |  |  |  |  | 400,000 | $ 300,000
Share-Based Payment Arrangement, Expense | $ |  |  |  |  | 633,000 | 606,000
Research and Development Expense [Member] |  |  |  |  |  |
Share-Based Payment Arrangement, Expense | $ |  |  |  |  | 263,000 | 240,000
General and Administrative Expense [Member] |  |  |  |  |  |
Share-Based Payment Arrangement, Expense | $ |  |  |  |  | 370,000 | 366,000
Restricted Stock Units [Member] |  |  |  |  |  |
Grant date fair value of the options vested | $ |  |  |  |  | 100,000 | $ 100,000
Unrecognized compensation cost related to outstanding RSUs | $ |  |  |  |  | $ 0 |
Performance Based Stock Units [Member] |  |  |  |  |  |
Number of Restricted Stock Units, Granted |  | 4,580 |  |  |  |
Number of Stock Units, Vested |  |  |  |  | 0 |
Risk free interest rate |  |  |  |  | 3.74% |
Expected stock price volatility |  |  |  |  | 76.60% |
Cost of equity |  |  |  |  | 27.99% |
Expected contractual life |  |  |  |  | 9 years 7 months 28 days |
Number of shares forfeited |  |  |  |  | 1,192 |
Number of shares unvested and outstanding |  |  |  |  | 2,952 | 4,144
Performance Based Stock Units [Member] | Tranche One [Member] |  |  |  |  |  |
Exercise price | $ / shares |  | $ 48 |  |  |  |
Award Vesting Rights Percentage |  | 50.00% |  |  |  |
Consecutive trading day period | Days |  | 20 |  |  |  |
Granted, Weighted Average Grant Date Fair Value | $ / shares |  |  |  |  | $ 22.5 |
Service period |  |  |  |  | 1 year 9 months |
Performance Based Stock Units [Member] | Tranche Two [Member] |  |  |  |  |  |
Exercise price | $ / shares |  | $ 63.75 |  |  |  |
Award Vesting Rights Percentage |  | 50.00% |  |  |  |
Consecutive trading day period | Days |  | 20 |  |  |  |
Granted, Weighted Average Grant Date Fair Value | $ / shares |  |  |  |  | $ 22.05 |
Service period |  |  |  |  | 2 years 5 months 23 days |
Time-based RSU [Member] | Research and Development Expense [Member] |  |  |  |  |  |
Share-Based Payment Arrangement, Expense | $ |  |  |  | $ 125,000 |  |
Time-based RSU [Member] | General and Administrative Expense [Member] |  |  |  |  |  |
Share-Based Payment Arrangement, Expense | $ |  |  |  | $ 129,000 |  |
The 2021 EIP and Inducement Plan [Member] |  |  |  |  |  |
Common Stock capital shares reserved for future issuance (in shares) |  |  |  |  | 37,586 |
The 2021 EIP and Inducement Plan [Member] | Restricted Stock Units [Member] |  |  |  |  |  |
Number of Restricted Stock Units, Granted |  |  |  |  | 0 |
Number of Stock Units, Vested |  |  |  |  | 23,067 |
Exercise price | $ / shares |  |  |  |  | $ 0 | $ 17.3
Granted, Weighted Average Grant Date Fair Value | $ / shares |  |  |  |  | $ 0 |
Number of shares forfeited |  |  |  |  | 1,128 |
2013 Plan [Member] |  |  |  |  |  |
Common Stock capital shares reserved for future issuance (in shares) |  |  |  |  | 0 |
The 2021 ESPP [Member] |  |  |  |  |  |
Common Stock capital shares reserved for future issuance (in shares) |  |  |  |  | 19,086 |
Percentage of purchase price of common stock |  |  | 85.00% |  |  |
Maximum number of shares per employee (in shares) |  |  | 5,000 |  |  |
Maximum shares issued under ESPP | $ |  |  | $ 25,000,000 |  |  |
Shares issued under the ESPP |  |  |  |  | 4,501 |
Share based compensation expense | $ |  |  |  |  | $ 19,000,000 | $ 18,000,000
2021 Inducement Plan [Member] |  |  |  |  |  |
Common Stock capital shares reserved for future issuance (in shares) |  |  |  |  | 52,941 |
Number of options, Granted (in shares) | 66,666 |  |  |  |  |

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- Definition Per share or unit weighted-average fair value of nonvested award under share-based payment arrangement. Excludes share and unit options. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (c)(2)(i) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (c)(2)(ii) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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- Definition The estimated measure of the percentage by which a share price is expected to fluctuate during a period. Volatility also may be defined as a probability-weighted measure of the dispersion of returns about the mean. The volatility of a share price is the standard deviation of the continuously compounded rates of return on the share over a specified period. That is the same as the standard deviation of the differences in the natural logarithms of the stock prices plus dividends, if any, over the period. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (f)(2)(ii) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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