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Note 6 - Equity Incentive Plans (Tables) | 12 Months Ended
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Dec. 31, 2024
Table Text Block [Abstract] |
Schedule of Fair Value of Options Granted | The fair value of options granted during the years ended December 31, 2024 and December 31, 2023 is estimated as of the grant date using the Black-Scholes option pricing model using the assumptions in the following table:
|  | Year Ended December 31, |
|  | 2024 |  |  | 2023 |
Weighted-average exercise price per share |  | $ | 4.54 |  |  | $ | 20.85 |
Weighted-average expected term (years) |  |  | 5.65 |  |  |  | 5.66 |
Weighted-average risk-free interest rate |  |  | 4.03 | % |  |  | 4.08 | %
Weighted-average expected dividend yield |  |  | — |  |  |  | — |
Weighted-average volatility |  |  | 111.74 | % |  |  | 78.35 | %
Schedule of Summarized Stock Option Activity | The following table summarizes stock option activity and related information under the 2013 Plan, the 2021 EIP and the 2021 Inducement Plan for the year ended December 31, 2024:
|  | Number of Options |  |  | Weighted Average Exercise Price |  |  | Weighted Average Remaining Contractual Life (Years) |  |  | Aggregate Intrinsic Value (in thousands) |
Outstanding at December 31, 2023 |  |  | 44,276 |  |  | $ | 233.09 |  |  |  | 6.08 |  |  | $ | — |
Granted |  |  | 12,300 |  |  |  | 4.54 |  |  |  | — |  |  |  | — |
Exercised |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
Forfeited, expired or cancelled |  |  | (5,902 | ) |  |  | 335.18 |  |  |  | — |  |  |  | — |
Outstanding at December 31, 2024 |  |  | 50,674 |  |  |  | 166.48 |  |  |  | 8.75 |  |  |  | — |
Vested and expected to vest at December 31, 2024 |  |  | 50,674 |  |  |  | 166.48 |  |  |  | 8.75 |  |  |  | — |
Exercisable at December 31, 2024 |  |  | 22,825 |  |  |  | 349.89 |  |  |  | 8.44 |  |  |  | — |
Schedule of Restricted Stock Units Activity | The following table summarizes RSU activity and related information under the 2021 EIP and the 2021 Inducement Plan for the year ended December 31, 2024:
|  | Number of Restricted Stock Units |  |  | Weighted Average Grant Date Fair Value Per Share |  |  | Weighted Average Remaining Contractual Life (Years) |
Non-vested at December 31, 2023 |  |  | 24,195 |  |  | $ | 17.30 |  |  |  | 2.17 |
Granted |  |  | — |  |  |  | — |  |  |  | — |
Vested |  |  | (23,067 | ) |  |  | 17.23 |  |  |  | — |
Forfeited |  |  | (1,128 | ) |  |  | 18.84 |  |  |  | — |
Non-vested at December 31, 2024 |  |  | — |  |  |  | — |  |  |  | — |
Schedule of Stock-based Compensation for all Stock Awards | The allocation of stock-based compensation for all stock option, RSU and PSU awards is as follows (in thousands):
|  | Year Ended December 31, |
|  | 2024 |  |  | 2023 |
Research and development expense |  | $ | 263 |  |  | $ | 240 |
General and administrative expense |  |  | 370 |  |  |  | 366 |
Total |  | $ | 633 |  |  | $ | 606 |

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- Definition Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (c)(1) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (d) -SubTopic 10 -Topic 718 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (e) -SubTopic 10 -Topic 718 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 718 -SubTopic 10 -Subparagraph (f)(2) -Name Accounting Standards Codification -Paragraph 2 -Section 50 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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- Definition Disclosure of the number and weighted-average grant date fair value for restricted stock and restricted stock units that were outstanding at the beginning and end of the year, and the number of restricted stock and restricted stock units that were granted, vested, or forfeited during the year. + References No definition available. + Details
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