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Note 7 - Collaborations and License Agreements (Details Textual) |  | 12 Months Ended | 36 Months Ended |
--- | --- | --- | --- | ---
Oct. 27, 2022 USD ($) | Dec. 31, 2024 USD ($) Agreement shares | Dec. 31, 2023 USD ($) | Dec. 16, 2023 USD ($) | Oct. 20, 2023 Agreement
Collaborations and license agreements upfront fee |  | $ 1,000,000 |  |  |
Royalty expense |  | 6,750,000 |  | $ 4,500,000 |
License Revenue |  |  | $ 300,000 |  |
Maximum Aggregate Consideration |  |  |  | 5,000,000 |
Milestone payments |  |  |  | $ 1,500,000 |
Closing period of merger agreement |  |  |  | 48 months |
Proceeds Deposited into the CVR Escrow |  |  |  | 20.00% |
Accrued joint development expenses |  | $ 223,000 | 98,000 |  |
Contingent value right issued | shares |  | 1 |  |  |
Contingent value right, pro rata, net proceeds from sale or licensing |  | 80.00% |  |  |
Minimum [Member] |  |  |  |  |
CVR Agreement, distribution minimum amount |  | $ 300,000 |  | $ 300,000 |
Research and Development Expense [Member] |  |  |  |  |
Joint development expenses |  | $ 4,300,000 | 700,000 |  |
License Agreements with the Regents of the University of California [Member] |  |  |  |  |
Number of license agreements | Agreement |  | 3 |  |  |
Number of terminated license agreements | Agreement |  |  |  |  | 2
Sublicense fees |  |  | 25,000 |  |
Period of Expiration of License Agreement Description |  | The 2015 UC License will expire upon the expiration date of the longest-lived patent right licensed under the 2015 UC License. The Regents may terminate the 2015 UC License if: (i) a material breach by the Company is not cured within 60 days, (ii) the Company files a claim asserting the Regents licensed patent rights are invalid or unenforceable, or (iii) the Company files for bankruptcy. The Company also has the right to terminate the 2015 UC License at any time upon at least 90 days’ written notice. |  |  |
License Agreements with the Regents of the University of California [Member] | Minimum [Member] |  |  |  |  |
Royalty rate, portion of sublicense income to be paid, percentage of one-third of upfront payment and milestone payment received |  | 30.00% |  |  |
License Agreements with the Regents of the University of California [Member] | Maximum [Member] |  |  |  |  |
Royalty rate, portion of sublicense income to be paid, percentage of one-third of upfront payment and milestone payment received |  | 35.00% |  |  |
License Agreements with the Regents of the University of California [Member] | Research and Development Expense [Member] |  |  |  |  |
Sublicense fees |  | $ 0 |  |  |
Accrued royalties, current |  | $ 16,000 | $ 21,000 |  |
NSI-532.IGF-1 [Member] |  |  |  |  |
Collaborations and license agreements upfront fee | $ 0 |  |  |  |
Percentage cost in patent right | 100.00% |  |  |  |
Percentage of net revenue | 50.00% |  |  |  |

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