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Note 6 - Equity Incentive Plans (Tables)

12 Months Ended

Dec. 31, 2024

Table Text Block [Abstract]

Schedule of Fair Value of Options Granted

The fair value of options granted during the years ended December 31, 2024 and December 31, 2023 is estimated as of the grant date using the Black-Scholes option pricing model using the assumptions in the following table:

		Year Ended December 31,
		2024				2023
Weighted-average exercise price per share		$	4.54			$	20.85
Weighted-average expected term (years)			5.65				5.66
Weighted-average risk-free interest rate			4.03	%			4.08	%
Weighted-average expected dividend yield			—				—
Weighted-average volatility			111.74	%			78.35	%

Schedule of Summarized Stock Option Activity

The following table summarizes stock option activity and related information under the 2013 Plan, the 2021 EIP and the 2021 Inducement Plan for the year ended December 31, 2024:

		Number of Options				Weighted Average Exercise Price				Weighted Average Remaining Contractual Life (Years)				Aggregate Intrinsic Value (in thousands)
Outstanding at December 31, 2023			44,276			$	233.09				6.08			$	—
Granted			12,300				4.54				—				—
Exercised			—				—				—				—
Forfeited, expired or cancelled			(5,902	)			335.18				—				—
Outstanding at December 31, 2024			50,674				166.48				8.75				—
Vested and expected to vest at December 31, 2024			50,674				166.48				8.75				—
Exercisable at December 31, 2024			22,825				349.89				8.44				—

Schedule of Restricted Stock Units Activity

The following table summarizes RSU activity and related information under the 2021 EIP and the 2021 Inducement Plan for the year ended December 31, 2024:

		Number of Restricted Stock Units				Weighted Average Grant Date Fair Value Per Share				Weighted Average Remaining Contractual Life (Years)
Non-vested at December 31, 2023			24,195			$	17.30				2.17
Granted			—				—				—
Vested			(23,067	)			17.23				—
Forfeited			(1,128	)			18.84				—
Non-vested at December 31, 2024			—				—				—

Schedule of Stock-based Compensation for all Stock Awards

The allocation of stock-based compensation for all stock option, RSU and PSU awards is as follows (in thousands):

		Year Ended December 31,
		2024				2023
Research and development expense		$	263			$	240
General and administrative expense			370				366
Total		$	633			$	606

X

- Definition

Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement.

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