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Note 5 - Stockholders' Equity - Schedule of Stockholders' Equity warrant outstanding and exercisable (Details)	12 Months Ended
	Dec. 31, 2024 $ / shares shares
Number of warrants outstanding | shares	6,745,213	[1]
Weighted average exercise price | $ / shares	$ 4.53	[1]
Weighted Average Remaining Contractual Life (Years)	5 years 1 month 28 days	[1]
December 2024 Offering PreFunded Common Stock Warrants [Member]
Number of warrants outstanding | shares	2,027,000
Weighted average exercise price | $ / shares	$ 0.0001
December 2024 Offering Common Stock Warrants [Member]
Number of warrants outstanding | shares	3,278,688
Weighted average exercise price | $ / shares	$ 1.4
Weighted Average Remaining Contractual Life (Years)	4 years 11 months 12 days
May Two Thousand Twenty Four Offering [Member]
Number of warrants outstanding | shares	922,863
Weighted average exercise price | $ / shares	$ 1.4
Weighted Average Remaining Contractual Life (Years)	6 years 4 months 2 days
February 2024 Warrant Inducement Replacement Common Stock Warrants [Member]
Number of warrants outstanding | shares	228,158
Weighted average exercise price | $ / shares	$ 6.17
Weighted Average Remaining Contractual Life (Years)	4 years 1 month 2 days
August 2024 Offering Series 2 Common Stock Warrants [Member]
Number of warrants outstanding | shares	6,748
Weighted average exercise price | $ / shares	$ 1.4
Weighted Average Remaining Contractual Life (Years)	2 years 7 months 9 days
Bridge, January 2021, and July 2021 Common Stock Warrants [Member]
Number of warrants outstanding | shares	1,144
Weighted average exercise price | $ / shares	$ 58.2
Weighted Average Remaining Contractual Life (Years)	1 year 9 months
Placement Agent, Solicitor and Representative Common Stock Warrants [Member]
Number of warrants outstanding | shares	274,693
Weighted average exercise price | $ / shares	$ 10.98
Weighted Average Remaining Contractual Life (Years)	4 years 7 months 28 days
All Other Common Stock Warrants [Member]
Number of warrants outstanding | shares	5,919
Weighted average exercise price | $ / shares	$ 3,418.56
Weighted Average Remaining Contractual Life (Years)	1 year 6 months
[1] (1) The pre-funded common stock warrants granted and outstanding during the year ended December 31, 2024 have a perpetual term and are therefore excluded from the calculation of the weighted average remaining contractual life.

X

- Definition

Exercise price per share or per unit of warrants or rights outstanding.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 3
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481112/505-10-50-3

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+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Topic 718
-SubTopic 10
-Subparagraph (e)(1)
-Name Accounting Standards Codification
-Paragraph 2
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-Publisher FASB
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