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Note 6 - Equity Incentive Plans - Schedule of Summarized Stock Option Activity (Details) - USD ($)
$ / shares in Units, $ in Thousands
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Number of Options, Outstanding (in shares) 44,276  
Number of Options, Granted (in shares) 12,300  
Number of Options, Exercised (in shares) 0  
Number of Options, Forfeited, expired or cancelled (in shares) (5,902)  
Number of Options, Outstanding (in shares) 50,674 44,276
Number of Options, Vested and expected to vest (in shares) 50,674  
Number of Options, Exercisable (in shares) 22,825  
Options Outstanding, Weighted Average Exercise Price (in dollars per share) $ 233.09  
Options Granted, Weighted Average Exercise Price (in dollars per share) 4.54  
Options Forfeited, expired or cancelled, Weighted Average Exercise Price (in dollars per share) 335.18  
Options Outstanding, Weighted Average Exercise Price (in dollars per share) 166.48 $ 233.09
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price 166.48  
Options Exercisable, Weighted Average Exercise Price (in dollars per share) $ 349.89  
Options Outstanding, Weighted Average Remaining Contractual Life (Year) 8 years 9 months 6 years 29 days
Options Vested and expected to vest, Weighted Average Remaining Contractual Life (Year) 8 years 9 months  
Options Exercisable, Weighted Average Remaining Contractual Life (Year) 8 years 5 months 8 days  
Options Outstanding, Aggregate Intrinsic Value $ 0 $ 0
Options Vested and expected to vest, Aggregate Intrinsic Value 0  
Options Exercisable, Aggregate Intrinsic Value $ 0