Note 12 - Segment Information - Schedule of Reconciliation of Loss from Operations Disclosure Disclosure (Details) - USD ($) $ in Thousands	12 Months Ended
Dec. 31, 2024	Dec. 31, 2023
Segment Reporting Information [Line Items]
Restructuring costs	$ 0	$ 225
Total operating expenses	14,859	13,320
Operating Segments [Member]
Segment Reporting Information [Line Items]
Other research and development expenses	2,156	2,987
Other general and administrative expenses	5,478	6,069
Restructuring costs	0	225
Total operating expenses	14,859	13,320
Operating Segments [Member] \| PALI-2108 [Member]
Segment Reporting Information [Line Items]
Program expenses	7,070	736
Operating Segments [Member] \| Legacy [Member]
Segment Reporting Information [Line Items]
Program expenses	$ 155	$ 3,303

Program expenses.

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- Definition

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+ References

No definition available.

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- Definition

Amount of general and administrative expense classified as other.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Topic 220
-SubTopic 10
-Name Accounting Standards Codification
-Section S99
-Paragraph 2
-Subparagraph (SX 210.5-03(4))
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147483621/220-10-S99-2

Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 946
-SubTopic 220
-Name Accounting Standards Codification
-Section S99
-Paragraph 1
-Subparagraph (SX 210.6-07(2)(b))
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147479134/946-220-S99-1

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- Definition

Amount of other research and development expense.

+ References

Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 730
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 1
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482916/730-10-50-1

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- Definition

Amount, after cash payment, of expenses associated with exit or disposal activities pursuant to an authorized plan. Excludes expenses related to a discontinued operation or an asset retirement obligation.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Name Accounting Standards Codification
-Section 45
-Paragraph 28
-Subparagraph (b)
-SubTopic 10
-Topic 230
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482740/230-10-45-28

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- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

No definition available.

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