    <SEC-DOCUMENT>0001493152-25-013384-index.html : 20250915
    <SEC-HEADER>0001493152-25-013384.hdr.sgml : 20250915
    <ACCEPTANCE-DATETIME>20250915074858
    ACCESSION NUMBER:		0001493152-25-013384
    CONFORMED SUBMISSION TYPE:	ARS
    PUBLIC DOCUMENT COUNT:		1
    CONFORMED PERIOD OF REPORT:	20241231
    FILED AS OF DATE:		20250915
    DATE AS OF CHANGE:		20250915
    EFFECTIVENESS DATE:		20250915

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			PALISADE BIO, INC.
    		CENTRAL INDEX KEY:			0001357459
    		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
    		ORGANIZATION NAME:           	03 Life Sciences
    		EIN:				522007292
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		ARS
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-33672
    		FILM NUMBER:		251313193

    	BUSINESS ADDRESS:
    		STREET 1:		7750 EL CAMINO REAL, SUITE 5200
    		CITY:			CARLSBAD
    		STATE:			CA
    		ZIP:			92009
    		BUSINESS PHONE:		(858) 704-4900

    	MAIL ADDRESS:
    		STREET 1:		7750 EL CAMINO REAL, SUITE 5200
    		CITY:			CARLSBAD
    		STATE:			CA
    		ZIP:			92009

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	Seneca Biopharma, Inc.
    		DATE OF NAME CHANGE:	20200127

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	Neuralstem, Inc.
    		DATE OF NAME CHANGE:	20060324
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>ARS
    <SEQUENCE>1
    <FILENAME>formars.pdf
    <DESCRIPTION>ARS
    <TEXT>
    Document 1 - file: formars.pdf

    </DOCUMENT>
    </SEC-DOCUMENT>