    <SEC-DOCUMENT>0000950170-25-058982-index.html : 20250428
    <SEC-HEADER>0000950170-25-058982.hdr.sgml : 20250428
    <ACCEPTANCE-DATETIME>20250428085008
    ACCESSION NUMBER:		0000950170-25-058982
    CONFORMED SUBMISSION TYPE:	ARS
    PUBLIC DOCUMENT COUNT:		1
    CONFORMED PERIOD OF REPORT:	20241231
    FILED AS OF DATE:		20250428
    DATE AS OF CHANGE:		20250428
    EFFECTIVENESS DATE:		20250428

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			HCW Biologics Inc.
    		CENTRAL INDEX KEY:			0001828673
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		ORGANIZATION NAME:           	03 Life Sciences
    		EIN:				825024477
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		ARS
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-40591
    		FILM NUMBER:		25876263

    	BUSINESS ADDRESS:
    		STREET 1:		2929 N COMMERCE PKWY
    		CITY:			MIRAMAR
    		STATE:			FL
    		ZIP:			33025
    		BUSINESS PHONE:		954-842-2024

    	MAIL ADDRESS:
    		STREET 1:		2929 N COMMERCE PKWY
    		CITY:			MIRAMAR
    		STATE:			FL
    		ZIP:			33025
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>ARS
    <SEQUENCE>1
    <FILENAME>ars_20250428.pdf
    <DESCRIPTION>ARS
    <TEXT>
    Document 1 - file: ars_20250428.pdf

    </DOCUMENT>
    </SEC-DOCUMENT>