<SEC-DOCUMENT>0000930413-18-002569.txt : 20180813
<SEC-HEADER>0000930413-18-002569.hdr.sgml : 20180813
<ACCEPTANCE-DATETIME>20180813160041
ACCESSION NUMBER:		0000930413-18-002569
CONFORMED SUBMISSION TYPE:	SC 13G
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20180813
DATE AS OF CHANGE:		20180813

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Menlo Therapeutics Inc.
		CENTRAL INDEX KEY:			0001566044
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				453757789
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-90268
		FILM NUMBER:		181012221

	BUSINESS ADDRESS:	
		STREET 1:		200 CARDINAL WAY, 2ND FLOOR
		CITY:			REDWOOD CITY
		STATE:			CA
		ZIP:			94063
		BUSINESS PHONE:		650-486-1416

	MAIL ADDRESS:	
		STREET 1:		200 CARDINAL WAY, 2ND FLOOR
		CITY:			REDWOOD CITY
		STATE:			CA
		ZIP:			94063

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Menlo Therapeutics, Inc.
		DATE OF NAME CHANGE:	20170728

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Tigercat Pharma, Inc.
		DATE OF NAME CHANGE:	20130104

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			GREAT POINT PARTNERS LLC
		CENTRAL INDEX KEY:			0001281446
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G

	BUSINESS ADDRESS:	
		STREET 1:		165 MASON STREET, 3RD FLOOR
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
		BUSINESS PHONE:		203 971-3300

	MAIL ADDRESS:	
		STREET 1:		165 MASON STREET, 3RD FLOOR
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G
<SEQUENCE>1
<FILENAME>c91816_sc13g.htm
<TEXT>
<HTML>
<HEAD>
     <TITLE></TITLE>
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<BODY>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>UNITED STATES<BR>
SECURITIES AND EXCHANGE COMMISSION<BR>
Washington, D.C. 20549<BR>
<BR>
</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Schedule 13G</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Under the Securities Exchange Act of 1934<BR>
<BR>
</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>(Amendment No. )*</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 100%; border-bottom: Black 1px solid; font-weight: bold; text-align: center">Menlo
    Therapeutics Inc.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">(Name of Issuer)</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: Black 1px solid; font-weight: bold; text-align: center; padding-top: 10pt">Common Stock</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">(Title of Class of Securities)</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: Black 1px solid; font-weight: bold; text-align: center; padding-top: 10pt">586858102</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">(CUSIP Number)</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: Black 1px solid; font-weight: bold; text-align: center; padding-top: 10pt">August 3, 2018</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">(Date of Event which Requires Filing of this Statement)</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: left">Check the appropriate box to designate the rule
pursuant to which this Schedule is filed:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left; width: 36pt"><FONT STYLE="font-family: Wingdings">x</FONT></TD>
    <TD STYLE="text-align: left">Rule 13d-1(b)</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left"><FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD STYLE="text-align: left">Rule 13d-1(c)</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left"><FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD STYLE="text-align: left">Rule 13d-1(d)</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0pt">*The remainder of this cover
page shall be filled out for a reporting person&rsquo;s initial filing on this form with respect to the subject class of securities,
and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">The information required in the remainder of
this cover page shall not be deemed to be &ldquo;filed&rdquo; for the purpose of Section 18 of the Securities Exchange Act of 1934
(&ldquo;Act&rdquo;) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions
of the Act (however, see the Notes).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><B>Persons who respond to the collection of
information contained in this form are not required to respond unless the form displays a currently valid OMB control number.</B></P>


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<TR>
    <TD STYLE="width: 25%; border: Black 1px solid; text-align: center"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif">CUSIP No. 586858102</FONT></TD>
    <TD STYLE="vertical-align: top; width: 55%; text-align: center"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif; font-size: 16pt"><B>13G</B></FONT></TD>
    <TD STYLE="width: 20%; border: Black 1px solid; text-align: center"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif; font-size: 10pt">Page 2 of 9 Pages</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><B>&nbsp;</B></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="text-align: left; vertical-align: top">
    <TD STYLE="padding: 0 0 0 5pt; text-indent: 0; text-align: left; vertical-align: top; width: 36pt">
    <B>1.</B></TD>
    <TD STYLE="padding: 0; text-indent: 0"><P STYLE="margin: 0"><B>NAMES OF REPORTING PERSONS</B></P>
                    <P STYLE="margin: 0; font: 10pt Times New Roman, Times, Serif"><B>&nbsp;</B></P>
        <P STYLE="margin: 0">Great Point Partners, LLC</P>
        <P STYLE="margin: 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin: 0">I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):</P>
        <P STYLE="margin: 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin: 0">37-1475292</P></TD></TR>
<TR STYLE="text-align: left; vertical-align: top">
    <TD STYLE="padding: 0 0 0 5pt; text-indent: 0; text-align: left; vertical-align: top">&nbsp;</TD>
    <TD STYLE="padding: 0; text-indent: 0">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="3" STYLE="text-align: left; vertical-align: top; padding: 0 0 0 5pt; text-indent: 0"><B>2.</B></TD>
    <TD STYLE="padding: 0; text-indent: 0"><B>CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</B></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; padding: 0; text-indent: 0">(a)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></TD>
    </TR>
<TR>
    <TD STYLE="vertical-align: top; padding: 0; text-indent: 0"><P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>
                                                                <P STYLE="margin-top: 0; margin-bottom: 0">(b)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></P></TD>
    </TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; vertical-align: top; padding: 0 0 0 5pt; text-indent: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; text-indent: 0">&nbsp;</TD></TR>
<TR STYLE="background-color: rgb(204,204,204)">
    <TD STYLE="text-align: left; vertical-align: top; padding: 10pt 0 0 5pt; text-indent: 0"><B>3.</B></TD>
    <TD STYLE="padding: 10pt 0 0; text-indent: 0"><B>SEC USE ONLY</B></TD></TR>
<TR STYLE="background-color: rgb(204,204,204)">
    <TD STYLE="text-align: left; vertical-align: top; padding: 0 0 0 5pt; text-indent: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; text-indent: 0">&nbsp;</TD></TR>
<TR STYLE="background-color: rgb(204,204,204)">
    <TD STYLE="text-align: left; vertical-align: top; padding: 0 0 0 5pt; text-indent: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; text-indent: 0">&nbsp;</TD></TR>
<TR STYLE="background-color: White">
    <TD STYLE="text-align: left; vertical-align: top; padding: 0 0 0 5pt; text-indent: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; text-indent: 0">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; vertical-align: top; padding: 0 0 0 5pt; text-indent: 0"><B>4.</B></TD>
    <TD STYLE="padding: 0; text-indent: 0"><P STYLE="margin: 0"><B>CITIZENSHIP OR PLACE OF ORGANIZATION</B></P>
                                                       <P STYLE="margin: 0"><B>&nbsp;</B></P>
        <P STYLE="margin: 0; text-indent: 18pt">USA</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; vertical-align: top; padding: 0 0 0 5pt; text-indent: 0">&nbsp;</TD>
    <TD STYLE="padding: 0; text-indent: 0">&nbsp;</TD></TR>
</TABLE>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="4" STYLE="padding: 0; text-align: center; text-indent: 0; width: 20%"><P STYLE="margin-top: 0; margin-bottom: 0"><B>&nbsp;</B></P>
                                                                                       <P STYLE="margin-top: 0; margin-bottom: 0"><B>NUMBER OF SHARES</B></P>
                                                                                       <P STYLE="margin-top: 0; margin-bottom: 0; font: 6pt Times New Roman, Times, Serif"><B>&nbsp;</B></P>
                                                                                       <P STYLE="margin-top: 0; margin-bottom: 0"><B>BENEFICIALLY</B></P>
                                                                                       <P STYLE="margin-top: 0; margin-bottom: 0; font: 6pt Times New Roman, Times, Serif"><B>&nbsp;</B></P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0"><B>OWNED BY EACH</B></P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0; font: 6pt Times New Roman, Times, Serif">&nbsp;</P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0"><B>REPORTING PERSON</B></P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0; font: 6pt Times New Roman, Times, Serif">&nbsp;</P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0"><B>WITH</B></P></TD>
    <TD STYLE="text-align: left; padding: 0 0 0 5pt; text-indent: 0; width: 36pt"><B>5.</B></TD>
    <TD STYLE="padding: 0; text-indent: 0; text-align: left; vertical-align: top"><P STYLE="margin: 0"><B>SOLE VOTING POWER</B></P>
                                                                                              <P STYLE="margin: 0; font: 10pt Times New Roman, Times, Serif"><B>&nbsp;</B></P>
        <P STYLE="margin-top: 0; text-align: center; margin-bottom: 0">0</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; padding: 0 0 0 5pt; text-indent: 0"><B>6.</B></TD>
    <TD STYLE="padding: 0; text-indent: 0; text-align: left; vertical-align: top"><P STYLE="margin: 0"><B>SHARED VOTING POWER</B></P>
        <P STYLE="margin: 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin-top: 0; text-align: center; margin-bottom: 0">1,556,758</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; padding: 0 0 0 5pt; text-indent: 0"><B>7.</B></TD>
    <TD STYLE="padding: 0; text-indent: 0; text-align: left; vertical-align: top"><P STYLE="margin: 0"><B>SOLE DISPOSITIVE POWER</B></P>
        <P STYLE="margin: 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin-top: 0; text-align: center; margin-bottom: 0">0</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; padding: 0 0 0 5pt; text-indent: 0"><B>8.</B></TD>
    <TD STYLE="padding: 0; text-indent: 0; text-align: left; vertical-align: top"><P STYLE="margin: 0"><B>SHARED DISPOSITIVE POWER</B></P>
        <P STYLE="margin: 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin-top: 0; text-align: center; margin-bottom: 0">1,556,758</P></TD></TR>
</TABLE>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; vertical-align: top; padding: 10pt 0 0 5pt; text-indent: 0"><B>9.</B></TD>
    <TD COLSPAN="2" STYLE="padding: 10pt 0 0; text-indent: 0"><P STYLE="margin: 0"><B>AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
                                         REPORTING PERSON</B></P>

<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0; font: 10pt Times New Roman, Times, Serif; text-indent: 36pt">1,556,758</P>

</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: left; padding: 10pt 0 0 5pt; text-indent: 0; width: 36pt"><B>10.</B></TD>
    <TD STYLE="padding: 10pt 0 0; vertical-align: top; text-indent: 0"><B>CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
    SHARES</B> (See Instructions)</TD>
    <TD STYLE="text-align: left; padding: 10pt 0 0; text-indent: 0; vertical-align: bottom; width: 5%"><FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; vertical-align: top; padding: 10pt 0 0 5pt; text-indent: 0"><B>11.</B></TD>
    <TD STYLE="padding: 10pt 0 0; text-indent: 0"><P STYLE="margin: 0"><B>PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</B></P>
        <P STYLE="margin: 0">&nbsp;</P>
        <P STYLE="margin: 0; text-indent: 36pt">6.77%<SUP>1</SUP></P></TD>
    <TD STYLE="padding-top: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; vertical-align: top; padding: 10pt 0 0 5pt; text-indent: 0"><B>12.</B></TD>
    <TD STYLE="padding: 10pt 0 0; text-indent: 0"><P STYLE="margin: 0"><B>TYPE OF REPORTING PERSON</B> (See Instructions)</P>
        <P STYLE="margin: 0">&nbsp;</P>
        <P STYLE="margin: 0; text-indent: 36pt">IA</P></TD>
    <TD STYLE="padding-top: 10pt">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR>
    <TD STYLE="vertical-align: top; width: 18pt; font: bold 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0pt; padding-top: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-weight: normal"><SUP>1</SUP></FONT></TD>
    <TD STYLE="vertical-align: bottom; font: bold 10pt Times New Roman, Times, Serif; text-align: justify; text-indent: 0pt; padding-top: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-weight: normal">Based on a total of 22,977,998 shares outstanding, as reported in the Issuer&rsquo;s Form 10-Q filed with the SEC on August 1, 2018.</FONT></TD></TR>
</TABLE>

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<TR>
    <TD STYLE="width: 25%; border: Black 1px solid; text-align: center"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif">CUSIP No. 586858102</FONT></TD>
    <TD STYLE="vertical-align: top; width: 55%; text-align: center"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif; font-size: 16pt"><B>13G</B></FONT></TD>
    <TD STYLE="width: 20%; border: Black 1px solid; text-align: center"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif; font-size: 10pt">Page 3 of 9 Pages</FONT></TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; width: 36pt; padding-left: 5pt"><B>1.</B></TD>
    <TD><P STYLE="margin: 0"><B>NAMES OF REPORTING PERSONS</B></P>
        <P STYLE="margin: 0"><B STYLE="font-size: 10pt">&nbsp;</B></P>
        <P STYLE="margin: 0">Dr. Jeffrey R. Jay, M.D.</P>
        <P STYLE="margin: 0; font-size: 10pt">&nbsp;</P>
        <P STYLE="margin: 0">I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; padding-left: 5pt">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="3" STYLE="text-align: left; padding-left: 5pt"><B>2.</B></TD>
    <TD><B>CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</B></TD></TR>
<TR>
    <TD STYLE="vertical-align: top">(a)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></TD>
    </TR>
<TR>
    <TD STYLE="vertical-align: top"><P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>
                                    <P STYLE="margin-top: 0; margin-bottom: 0">(b)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></P></TD>
    </TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; padding-left: 5pt">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="background-color: rgb(204,204,204)">
    <TD STYLE="text-align: left; padding-top: 10pt; padding-left: 5pt"><B>3.</B></TD>
    <TD STYLE="padding-top: 10pt"><B>SEC USE ONLY</B></TD></TR>
<TR STYLE="background-color: rgb(204,204,204)">
    <TD STYLE="text-align: left; padding-left: 5pt">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="background-color: rgb(204,204,204)">
    <TD STYLE="text-align: left; padding-left: 5pt">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; padding-left: 5pt">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; padding-bottom: 10pt; padding-left: 5pt"><B>4.</B></TD>
    <TD STYLE="padding-bottom: 10pt"><P STYLE="margin: 0"><B>CITIZENSHIP OR PLACE OF ORGANIZATION</B></P>
        <P STYLE="margin: 0; font-size: 10pt"><B>&nbsp;</B></P>
        <P STYLE="margin: 0; text-indent: 0">USA</P></TD></TR>
</TABLE>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="4" STYLE="text-align: center; width: 20%"><P STYLE="margin-top: 0; margin-bottom: 0"><B>&nbsp;</B></P>
                                                           <P STYLE="margin-top: 0; margin-bottom: 0"><B>NUMBER OF SHARES</B></P>
                                                           <P STYLE="margin-top: 0; margin-bottom: 0; font: 6pt Times New Roman, Times, Serif"><B>&nbsp;</B></P>
                                                           <P STYLE="margin-top: 0; margin-bottom: 0"><B>BENEFICIALLY</B></P>
                                                           <P STYLE="margin-top: 0; margin-bottom: 0; font: 6pt Times New Roman, Times, Serif"><B>&nbsp;</B></P>
                                                           <P STYLE="margin-top: 0; margin-bottom: 0"><B>OWNED BY EACH</B></P>
                                                           <P STYLE="margin-top: 0; margin-bottom: 0; font: 6pt Times New Roman, Times, Serif"><B>&nbsp;</B></P>
                                                           <P STYLE="margin-top: 0; margin-bottom: 0"><B>REPORTING PERSON</B></P>
                                                           <P STYLE="margin-top: 0; margin-bottom: 0; font: 6pt Times New Roman, Times, Serif"><B>&nbsp;</B></P>
                                                           <P STYLE="margin-top: 0; margin-bottom: 0"><B>WITH</B></p></TD>
    <TD STYLE="text-align: left; width: 36pt; padding-left: 5pt"><B>5.</B></TD>
    <TD><P STYLE="margin: 0"><B>SOLE VOTING POWER</B></P>
        <P STYLE="margin: 0; text-align: center">&nbsp;</P>
        <P STYLE="margin: 0; text-align: center">0</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; padding-left: 5pt"><B>6.</B></TD>
    <TD><P STYLE="margin: 0"><B>SHARED VOTING POWER</B></P>
        <P STYLE="margin: 0; text-align: center">&nbsp;</P>
        <P STYLE="margin: 0; text-align: center">1,556,758</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; padding-left: 5pt"><B>7.</B></TD>
    <TD><P STYLE="margin: 0"><B>SOLE DISPOSITIVE POWER</B></P>
        <P STYLE="margin: 0; text-align: center">&nbsp;</P>
        <P STYLE="margin: 0; text-align: center">0</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; padding-left: 5pt"><B>8.</B></TD>
    <TD><P STYLE="margin: 0"><B>SHARED DISPOSITIVE POWER</B></P>
        <P STYLE="margin: 0; text-align: center">&nbsp;</P>
        <P STYLE="margin: 0; text-align: center">1,556,758</P></TD></TR>
</TABLE>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; padding-top: 10pt; width: 36pt; padding-left: 5pt"><B>9.</B></TD>
    <TD STYLE="padding-top: 10pt"><P STYLE="margin: 0"><B>AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</B></P>
                                 <P STYLE="margin: 0"><B>&nbsp;</B></P>
        <P STYLE="margin: 0; text-indent: 36pt">1,556,758</P></TD>
    <TD STYLE="width: 5%">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: left; padding-top: 10pt; padding-left: 5pt"><B>10.</B></TD>
    <TD STYLE="vertical-align: top; padding-top: 10pt"><B>CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
    </B>(See Instructions)</TD>
    <TD STYLE="vertical-align: bottom; padding-top: 10pt"><FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; padding-top: 10pt; padding-left: 5pt"><B>11.</B></TD>
    <TD STYLE="padding-top: 10pt"><P STYLE="margin: 0"><B>PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</B></P>
        <P STYLE="margin: 0">&nbsp;</P>
        <P STYLE="margin: 0; text-indent: 36pt">6.77%<SUP>1</SUP></P></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; padding-top: 10pt; padding-left: 5pt"><B>12.</B></TD>
    <TD STYLE="padding-top: 10pt"><P STYLE="margin: 0"><B>TYPE OF REPORTING PERSON</B> (See Instructions)</P>
        <P STYLE="margin: 0">&nbsp;</P>
        <P STYLE="margin: 0; text-indent: 36pt">IN</P></TD>
    <TD>&nbsp;</TD></TR>
</TABLE>

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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 12pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR>
    <TD STYLE="width: 25%; border: Black 1px solid; text-align: center"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif">CUSIP No. 586858102</FONT></TD>
    <TD STYLE="vertical-align: top; width: 55%; text-align: center"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif; font-size: 16pt"><B>13G</B></FONT></TD>
    <TD STYLE="width: 20%; border: Black 1px solid; text-align: center"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif; font-size: 10pt">Page 4 of 9 Pages</FONT></TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; width: 36pt; padding-left: 5pt"><B>1.</B></TD>
    <TD><P STYLE="margin: 0"><B>NAMES OF REPORTING PERSONS</B></P>
        <P STYLE="margin: 0"><B>&nbsp;</B></P>
        <P STYLE="margin: 0">Mr. David Kroin</P>
        <P STYLE="margin: 0">&nbsp;</P>
        <P STYLE="margin: 0">I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; padding-left: 5pt">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="3" STYLE="text-align: left; padding-left: 5pt"><B>2.</B></TD>
    <TD><B>CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</B></TD></TR>
<TR>
    <TD STYLE="vertical-align: top">(a)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></TD>
    </TR>
<TR>
    <TD STYLE="vertical-align: top"><P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>
                                    <P STYLE="margin-top: 0; margin-bottom: 0">(b)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></P></TD>
    </TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; padding-left: 5pt">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="background-color: rgb(204,204,204)">
    <TD STYLE="text-align: left; padding-top: 10pt; padding-left: 5pt"><B>3.</B></TD>
    <TD STYLE="padding-top: 10pt"><B>SEC USE ONLY</B></TD></TR>
<TR STYLE="background-color: rgb(204,204,204)">
    <TD STYLE="text-align: left; padding-left: 5pt">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="background-color: rgb(204,204,204)">
    <TD STYLE="text-align: left; padding-left: 5pt">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; padding-left: 5pt">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; padding-left: 5pt"><B>4.</B></TD>
    <TD STYLE="padding-bottom: 10pt"><P STYLE="margin: 0"><B>CITIZENSHIP OR PLACE OF ORGANIZATION</B></P>
        <P STYLE="margin: 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin: 0">USA</P></TD></TR>
</TABLE>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="4" STYLE="text-align: center; width: 20%"><P STYLE="margin-top: 0; margin-bottom: 0"><B>&nbsp;</B></P>
                                                           <P STYLE="margin-top: 0; margin-bottom: 0"><B>NUMBER OF SHARES</B></P>
                                                           <P STYLE="font: 6pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
                                                           <P STYLE="margin-top: 0; margin-bottom: 0"><B>BENEFICIALLY</B></P>
                                                           <P STYLE="font: 6pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
                                                           <P STYLE="margin-top: 0; margin-bottom: 0"><B>OWNED BY EACH</B></P>
                                                           <P STYLE="font: 6pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
                                                           <P STYLE="margin-top: 0; margin-bottom: 0"><B>REPORTING PERSON</B></P>
                                                           <P STYLE="font: 6pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
                                                           <P STYLE="margin-top: 0; margin-bottom: 0"><B>WITH</B></p></TD>
    <TD STYLE="text-align: left; width: 36pt; padding-left: 5pt"><B>5.</B></TD>
    <TD><P STYLE="margin: 0"><B>SOLE VOTING POWER</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
        <P STYLE="margin: 0; text-align: center">0</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; padding-left: 5pt"><B>6.</B></TD>
    <TD><P STYLE="margin: 0"><B>SHARED VOTING POWER</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
        <P STYLE="margin: 0; text-align: center">1,556,758</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; padding-left: 5pt"><B>7.</B></TD>
    <TD><P STYLE="margin: 0"><B>SOLE DISPOSITIVE POWER</B></P>
       <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
        <P STYLE="margin: 0; text-align: center">0</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; padding-left: 5pt"><B>8.</B></TD>
    <TD><P STYLE="margin: 0"><B>SHARED DISPOSITIVE POWER</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
        <P STYLE="margin: 0; text-align: center">1,556,758</P></TD></TR>
</TABLE>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; padding-top: 10pt; width: 36pt; padding-left: 5pt"><B>9.</B></TD>
    <TD STYLE="padding-top: 10pt"><P STYLE="margin: 0"><B>AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</B></P>
        <P STYLE="margin: 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin: 0; text-indent: 36pt">1,556,758</P></TD>
    <TD STYLE="width: 5%">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: left; padding-top: 10pt; padding-left: 5pt"><B>10.</B></TD>
    <TD STYLE="vertical-align: top; padding-top: 10pt"><B>CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
    </B>(See Instructions)</TD>
    <TD STYLE="vertical-align: bottom; padding-top: 10pt; font-family: Wingdings">o</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; padding-top: 10pt; padding-left: 5pt"><B>11.</B></TD>
    <TD STYLE="padding-top: 10pt"><P STYLE="margin: 0"><B>PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</B></P>
        <P STYLE="margin: 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin: 0 0 0 36pt">6.77%<SUP>1</SUP></P></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; padding-top: 10pt; padding-left: 5pt"><B>12.</B></TD>
    <TD STYLE="padding-top: 10pt"><P STYLE="margin: 0"><B>TYPE OF REPORTING PERSON</B> (See Instructions)</P>
        <P STYLE="margin: 0; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin: 0 0 0 36pt">IN</P></TD>
    <TD>&nbsp;</TD></TR>
</TABLE>

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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 12pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR>
    <TD STYLE="width: 25%; border: Black 1px solid; text-align: center"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif">CUSIP No. 586858102</FONT></TD>
    <TD STYLE="vertical-align: top; width: 55%; text-align: center"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif; font-size: 16pt"><B>13G</B></FONT></TD>
    <TD STYLE="width: 20%; border: Black 1px solid; text-align: center"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif; font-size: 10pt">Page
    5  of 9 Pages</FONT></TD></TR>
<TR STYLE="vertical-align: top; font-size: 10pt">
    <TD COLSPAN="3" STYLE="text-align: center; font-size: 10pt">&nbsp;</TD></TR>
</TABLE>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; vertical-align: top; width: 54pt"><FONT STYLE="font-size: 10pt"><B>Item 1.</B></FONT></TD>
    <TD STYLE="width: 36pt">&nbsp;</TD>
    <TD STYLE="width: 36pt">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(a)</FONT></TD>
    <TD COLSPAN="2"><P STYLE="margin: 0pt 0">Name of Issuer</P>

<P STYLE="margin: 0pt 0">&nbsp;</P>

<P STYLE="margin: 0pt 0">Menlo Therapeutics Inc.</P>

<P STYLE="margin: 0pt 0">&nbsp;</P>

</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(b)</FONT></TD>
    <TD COLSPAN="2"><P STYLE="margin: 0pt 0">Address of Issuer&rsquo;s Principal Executive Offices</P>

<P STYLE="margin: 0pt 0">&nbsp;</P>

<P STYLE="margin: 0pt 0">200 Cardinal Way, 2nd Floor, Redwood City, CA 94063</P>

<P STYLE="margin: 0pt 0">&nbsp;</P>

</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left"><FONT STYLE="font-size: 10pt"><B>Item 2.</B></FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(a)</FONT></TD>
    <TD COLSPAN="2"><P STYLE="margin: 0pt 0">Name of Person Filing</P>

<P STYLE="margin: 0pt 0">&nbsp;</P>

<P STYLE="margin: 0pt 0 0pt 33pt">Great Point Partners, LLC<BR> Dr. Jeffrey R. Jay, M.D.</P>

<P STYLE="margin: 0pt 0 0pt 33pt">Mr. David Kroin</P>

<P STYLE="margin: 0pt 0 0pt 33pt">&nbsp;</P>

</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: left">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: justify; padding-bottom: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">The Reporting Persons have entered into a Joint Filing Agreement, dated August 13, 2018, a copy of which is filed with this Schedule 13G as <U>Exhibit A</U>, pursuant to which the Reporting Persons have agreed to file this statement jointly in accordance with the provisions of Rule 13d-1(k)(1) under the Act.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(b)</FONT></TD>
    <TD COLSPAN="2"><P STYLE="margin: 0pt 0">Address of Principal Business Office, or if none, Residence</P>

<P STYLE="margin: 0pt 0">&nbsp;</P>

<P STYLE="margin: 0pt 0 0pt 3pt">The address of the principal business office of each of the Reporting Persons is</P>

<P STYLE="margin: 0pt 0 0pt 10pt">&nbsp;</P>

<P STYLE="margin: 0pt 0 0pt 23.9pt">165 Mason Street, 3rd Floor</P>

<P STYLE="margin: 0pt 0 0pt 23.9pt">Greenwich, CT 06830</P>

<P STYLE="margin: 0pt 0 0pt 23.9pt">&nbsp;</P>

</TD></TR>
<TR>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(c)</FONT></TD>
    <TD COLSPAN="2"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Citizenship</FONT></TD></TR>
<TR>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: justify; padding-bottom: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Great Point Partners, LLC is a limited liability company organized under the laws of the State of Delaware. Dr. Jeffrey R. Jay, M.D. is a citizen of the United States. Mr. David Kroin is a citizen of the United States.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(d)</FONT></TD>
    <TD COLSPAN="2"><P STYLE="margin: 0pt 0">Title of Class of Securities</P>

<P STYLE="margin: 0pt 0 0pt 3pt">&nbsp;</P>

<P STYLE="margin: 0pt 0">Common Stock</P>

<P STYLE="margin: 0pt 0 0pt 3pt">&nbsp;</P>

</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(e)</FONT></TD>
    <TD COLSPAN="2"><P STYLE="margin: 0pt 0">CUSIP Number</P>

<P STYLE="margin: 0pt 0 0pt 3pt">&nbsp;</P>

<P STYLE="margin: 0pt 0">586858102</P>

<P STYLE="margin: 0pt 0 0pt 3pt">&nbsp;</P>

</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; vertical-align: top"><FONT STYLE="font-size: 10pt"><B>Item 3.</B></FONT></TD>
    <TD COLSPAN="3" STYLE="padding-bottom: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>If this statement is filed pursuant to &sect;240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:</B></FONT></TD></TR>
</TABLE>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 54pt; text-align: center">&nbsp;</TD>
    <TD STYLE="padding-bottom: 10pt; width: 18pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(a)</FONT></TD>
    <TD STYLE="padding-bottom: 10pt; width: 18pt"><FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD STYLE="padding-bottom: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Broker or dealer registered under Section 15 of the Act (15 U.S.C. 78o) </FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="padding-bottom: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(b)</FONT></TD>
    <TD STYLE="padding-bottom: 10pt"><FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD STYLE="padding-bottom: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Bank as defined in Section 3(a)(6) of the Act (15 U.S.C. 78c).</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="padding-bottom: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(c)</FONT></TD>
    <TD STYLE="padding-bottom: 10pt"><FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD STYLE="padding-bottom: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Insurance company as defined in Section 3(a)(19) of the Act (15. U.S.C. 78c).</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="padding-bottom: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(d)</FONT></TD>
    <TD STYLE="padding-bottom: 10pt"><FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD STYLE="padding-bottom: 10pt">
        <P STYLE="margin: 0pt 0">Investment Company registered under Section 8 of the Investment Company Act of 1940 (15 U.S.C.
80a-8).</P>

</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="padding-bottom: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(e)</FONT></TD>
    <TD STYLE="padding-bottom: 10pt"><FONT STYLE="font-family: Wingdings">x</FONT></TD>
    <TD STYLE="padding-bottom: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">An investment adviser in accordance with &sect;240.13d-1(b)(1)(ii)(E).</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(f)</FONT></TD>
    <TD><FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD>
        <P STYLE="margin: 0pt 0">An employee benefit plan or endowment fund in accordance with &sect;240.13d-1(b)(1)(ii)(F).</P>

</TD></TR>
</TABLE>

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<TR>
    <TD STYLE="width: 25%; border: Black 1px solid; text-align: center"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif">CUSIP No. 586858102</FONT></TD>
    <TD STYLE="vertical-align: top; width: 55%; text-align: center"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif; font-size: 16pt"><B>13G</B></FONT></TD>
    <TD STYLE="width: 20%; border: Black 1px solid; text-align: center"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif; font-size: 10pt">Page
    6       of 9 Pages</FONT></TD></TR>
<TR STYLE="vertical-align: top; font-size: 10pt">
    <TD COLSPAN="3" STYLE="text-align: center; font-size: 10pt">&nbsp;</TD></TR>
</TABLE>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 54pt; text-align: center">&nbsp;</TD>
    <TD STYLE="width: 18pt">(g)</TD>
    <TD STYLE="width: 18pt"><FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD><P STYLE="margin: 0pt 0">A parent holding company or control person in accordance with &sect;240.13d-1(b)(1)(ii)(G).</P>
        <P STYLE="margin: 0pt 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>(h)</TD>
    <TD><FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD><P STYLE="margin: 0pt 0">A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12
        U.S.C. 1813).</P>
        <P STYLE="margin: 0pt 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>(i)</TD>
    <TD><FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD><P STYLE="margin: 0pt 0">A church plan that is excluded from the definition of an investment company under Section
        3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3).</P>
        <P STYLE="margin: 0pt 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>(j)</TD>
    <TD><FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD>Group, in accordance with &sect;240.13d-1(b)(1)(ii)(J).</TD></TR>
</TABLE>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; font-family: Times New Roman, Times, Serif; width: 54pt">&nbsp;</TD>
    <TD STYLE="text-align: justify; width: 36pt">&nbsp;</TD>
    <TD STYLE="text-align: justify; width: 36pt">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; font-family: Times New Roman, Times, Serif; vertical-align: top"><FONT STYLE="font-size: 10pt"><B>Item 4.</B></FONT></TD>
    <TD COLSPAN="3" STYLE="text-align: justify; padding-bottom: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>Ownership</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; font-family: Times New Roman, Times, Serif">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Biomedical Value Fund, L.P. (&ldquo;<U>BVF</U>&rdquo;) is the record owner of 473,255 shares of Common Stock (the &ldquo;<U>BVF Shares</U>&rdquo;). Great Point Partners, LLC (&ldquo;<U>Great Point</U>&rdquo;) is the investment manager of BVF, and by virtue of such status may be deemed to be the beneficial owner of the BVF Shares. Each of Dr. Jeffrey R. Jay, M.D. (&ldquo;<U>Dr. Jay</U>&rdquo;), as senior managing member of Great Point, and Mr. David Kroin (&ldquo;<U>Mr. Kroin</U>&rdquo;), as special managing member of Great Point, has voting and investment power with respect to the BVF Shares, and therefore may be deemed to be the beneficial owner of the BVF Shares. </FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Biomedical Offshore Value Fund, Ltd. (&ldquo;<U>BOVF</U>&rdquo;) is the record owner of 611,805 shares of Common Stock (the &ldquo;<U>BOVF Shares</U>&rdquo;). Great Point is the investment manager of BOVF, and by virtue of such status may be deemed to be the beneficial owner of the BOVF Shares. Each of Dr. Jay, as senior managing member of Great Point, and Mr. Kroin, as special managing member of Great Point, has voting and investment power with respect to the BOVF Shares, and therefore may be deemed to be the beneficial owner of the BOVF Shares. </FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">GEF-SMA, LP (&ldquo;<U>GEF-SMA</U>&rdquo;) is the record owner of 471,698 shares of Common Stock (the &ldquo;<U>GEF-SMA Shares</U>&rdquo;). Great Point is the investment manager of GEF-SMA, and by virtue of such status may be deemed to be the beneficial owner of the GEF-SMA Shares. Each of Dr. Jay, as senior managing member of Great Point, and Mr. Kroin, as special managing member of Great Point, has voting and investment power with respect to the GEF-SMA Shares, and therefore may be deemed to be the beneficial owner of the GEF-SMA Shares. </FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Notwithstanding the above, Great Point, Dr. Jay and Mr. Kroin disclaim beneficial ownership of the BVF Shares, the BOVF Shares and the GEF-SMA Shares described above, except to the extent of their respective pecuniary interests.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="padding-bottom: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">1.</FONT></TD>
    <TD COLSPAN="2" STYLE="padding-bottom: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>Great Point Partners, LLC</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="padding-bottom: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(a)</FONT></TD>
    <TD COLSPAN="2" STYLE="padding-bottom: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Amount beneficially owned: 1,556,758</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="padding-bottom: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(b)</FONT></TD>
    <TD COLSPAN="2" STYLE="padding-bottom: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Percent of class: 6.77%</FONT><SUP>1</SUP></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="padding-bottom: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(c)</FONT></TD>
    <TD COLSPAN="2" STYLE="padding-bottom: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Number of shares as to which the person has:</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="padding-bottom: 10pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(i) </FONT></TD>
    <TD STYLE="padding-bottom: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Sole power to vote or to direct the vote:&nbsp;&nbsp;0 </FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="padding-bottom: 10pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(ii)</FONT></TD>
    <TD STYLE="padding-bottom: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"> Shared power to vote or to direct the vote: 1,556,758</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="padding-bottom: 10pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(iii)</FONT></TD>
    <TD STYLE="padding-bottom: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"> Sole power to dispose or to direct the disposition of:&nbsp;&nbsp;0 </FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(iv)</FONT></TD>
    <TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif"> Shared power to dispose or to direct the disposition of: 1,556,758 </FONT></TD></TR>
</TABLE>

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<TR>
    <TD STYLE="width: 25%; border: Black 1px solid; text-align: center"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif">CUSIP No. 586858102</FONT></TD>
    <TD STYLE="vertical-align: top; width: 55%; text-align: center"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif; font-size: 16pt"><B>13G</B></FONT></TD>
    <TD STYLE="width: 20%; border: Black 1px solid; text-align: center"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif; font-size: 10pt">Page
    7       of 9 Pages</FONT></TD></TR>
<TR STYLE="vertical-align: top; font-size: 10pt">
    <TD COLSPAN="3" STYLE="text-align: center; font-size: 10pt">&nbsp;</TD></TR>
</TABLE>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding-bottom: 10pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 10pt">2.</TD>
    <TD COLSPAN="2" STYLE="padding-bottom: 10pt"><B>Dr. Jeffrey R. Jay, M.D.</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding-bottom: 10pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 10pt">(a)</TD>
    <TD COLSPAN="2" STYLE="padding-bottom: 10pt">Amount beneficially owned: 1,556,758</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding-bottom: 10pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 10pt">(b)</TD>
    <TD COLSPAN="2" STYLE="padding-bottom: 10pt">Percent of class: 6.77%<SUP>1</SUP></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding-bottom: 10pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 10pt">(c)</TD>
    <TD COLSPAN="2" STYLE="padding-bottom: 10pt">Number of shares as to which the person has:</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; width: 54pt; padding-bottom: 10pt">&nbsp;</TD>
    <TD STYLE="width: 36pt; padding-bottom: 10pt">&nbsp;</TD>
    <TD STYLE="width: 36pt; padding-bottom: 10pt">(i)</TD>
    <TD STYLE="padding-bottom: 10pt">Sole power to vote or to direct the vote: 0</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding-bottom: 10pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 10pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 10pt">(ii)</TD>
    <TD STYLE="padding-bottom: 10pt">Shared power to vote or to direct the vote: 1,556,758</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding-bottom: 10pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 10pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 10pt">(iii)</TD>
    <TD STYLE="padding-bottom: 10pt">Sole power to dispose or to direct the disposition of: 0</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding-bottom: 10pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 10pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 10pt">(iv)</TD>
    <TD STYLE="padding-bottom: 10pt">Shared power to dispose or to direct the disposition of: 1,556,758</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding-bottom: 10pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 10pt">3.</TD>
    <TD COLSPAN="2" STYLE="padding-bottom: 10pt"><B>Mr. David Kroin</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding-bottom: 10pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 10pt">(a)</TD>
    <TD COLSPAN="2" STYLE="padding-bottom: 10pt">Amount beneficially owned: 1,556,758</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding-bottom: 10pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 10pt">(b)</TD>
    <TD COLSPAN="2" STYLE="padding-bottom: 10pt">Percent of class: 6.77%<SUP>1</SUP></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding-bottom: 10pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 10pt">(c)</TD>
    <TD COLSPAN="2" STYLE="padding-bottom: 10pt">Number of shares as to which the person has:</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding-bottom: 10pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 10pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 10pt">(i)</TD>
    <TD STYLE="padding-bottom: 10pt">Sole power to vote or to direct the vote: 0</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding-bottom: 10pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 10pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 10pt">(ii)</TD>
    <TD STYLE="padding-bottom: 10pt">Shared power to vote or to direct the vote: 1,556,758</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding-bottom: 10pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 10pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 10pt">(iii)</TD>
    <TD STYLE="padding-bottom: 10pt">Sole power to dispose or to direct the disposition of: 0</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>(iv) </TD>
    <TD>Shared power to dispose or to direct the disposition of: 1,556,758</TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Tahoma, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 54pt; font-family: Times New Roman, Times, Serif; font-weight: bold; padding-bottom: 10pt; text-align: left"><FONT STYLE="font-size: 10pt">Item 5.</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif; font-weight: bold; padding-bottom: 10pt"><FONT STYLE="font-size: 10pt">Ownership of Five Percent or Less of a Class</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="text-align: justify; font-family: Times New Roman, Times, Serif; padding-bottom: 10pt; text-indent: 54pt"><FONT STYLE="font-size: 10pt">If
    this statement is being filed to report the fact that as of the date hereof each of the Reporting Persons has ceased to be
    the beneficial owner of more than five percent of the class of securities, check the following <FONT STYLE="font-family: Wingdings">o</FONT>.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman, Times, Serif; font-weight: bold; padding-bottom: 10pt; text-align: left"><FONT STYLE="font-size: 10pt">Item 6.</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif; font-weight: bold; padding-bottom: 10pt"><FONT STYLE="font-size: 10pt">Ownership of More than Five Percent on Behalf of Another Person:</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; font-family: Times New Roman, Times, Serif; padding-bottom: 10pt">&nbsp;</TD>
    <TD STYLE="text-align: left; font-family: Times New Roman, Times, Serif; padding-bottom: 10pt"><FONT STYLE="font-size: 10pt">See Item 4.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman, Times, Serif; font-weight: bold; padding-bottom: 10pt; text-align: left"><FONT STYLE="font-size: 10pt">Item 7.</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif; font-weight: bold; padding-bottom: 10pt"><FONT STYLE="font-size: 10pt">Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; font-family: Times New Roman, Times, Serif; padding-bottom: 10pt">&nbsp;</TD>
    <TD STYLE="text-align: left; font-family: Times New Roman, Times, Serif; padding-bottom: 10pt"><FONT STYLE="font-size: 10pt">Not Applicable.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman, Times, Serif; font-weight: bold; padding-bottom: 10pt; text-align: left"><FONT STYLE="font-size: 10pt">Item 8.</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif; font-weight: bold; padding-bottom: 10pt"><FONT STYLE="font-size: 10pt">Identification and Classification of Members of the Group</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; font-family: Times New Roman, Times, Serif; padding-bottom: 10pt">&nbsp;</TD>
    <TD STYLE="text-align: left; font-family: Times New Roman, Times, Serif; padding-bottom: 10pt"><FONT STYLE="font-size: 10pt">Not Applicable.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman, Times, Serif; font-weight: bold; padding-bottom: 10pt; text-align: left"><FONT STYLE="font-size: 10pt">Item 9.</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif; font-weight: bold; padding-bottom: 10pt"><FONT STYLE="font-size: 10pt">Notice of Dissolution of Group</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; font-family: Times New Roman, Times, Serif; padding-bottom: 10pt">&nbsp;</TD>
    <TD STYLE="text-align: left; font-family: Times New Roman, Times, Serif; padding-bottom: 10pt"><FONT STYLE="font-size: 10pt">Not Applicable.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman, Times, Serif; font-weight: bold; padding-bottom: 10pt; text-align: left"><FONT STYLE="font-size: 10pt">Item 10.</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif; font-weight: bold; padding-bottom: 10pt"><FONT STYLE="font-size: 10pt">Certification</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">By signing below I certify
that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose
of or with the effect of changing or influencing the control of the issuer of</P>




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<TR>
    <TD STYLE="width: 25%; border: Black 1px solid; text-align: center"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif">CUSIP No. 586858102</FONT></TD>
    <TD STYLE="vertical-align: top; width: 55%; text-align: center"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif; font-size: 16pt"><B>13G</B></FONT></TD>
    <TD STYLE="width: 20%; border: Black 1px solid; text-align: center"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif; font-size: 10pt">Page
    8       of 9 Pages</FONT></TD></TR>
<TR STYLE="vertical-align: top; font-size: 10pt">
    <TD COLSPAN="3" STYLE="text-align: center; font-size: 10pt">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">the securities and were
not acquired and are not held in connection with or as participant in any transaction having that purpose or effect.</P>


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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 12pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR>
    <TD STYLE="width: 25%; border: Black 1px solid; text-align: center"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif">CUSIP No. 586858102</FONT></TD>
    <TD STYLE="vertical-align: top; width: 55%; text-align: center"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif; font-size: 16pt"><B>13G</B></FONT></TD>
    <TD STYLE="width: 20%; border: Black 1px solid; text-align: center"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif; font-size: 10pt">Page
    9       of 9 Pages</FONT></TD></TR>
<TR STYLE="vertical-align: top; font-size: 10pt">
    <TD COLSPAN="3" STYLE="text-align: center; font-size: 10pt">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B><U>SIGNATURE</U></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">After reasonable inquiry
and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">Date: August 13, 2018</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">GREAT POINT PARTNERS, LLC</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 49%">&nbsp;</TD>
    <TD STYLE="width: 1%">By:&nbsp;</TD>
    <TD STYLE="width: 40%; border-bottom: Black 1px solid">/s/ Dr. Jeffrey R. Jay, M.D.</TD>
    <TD STYLE="width: 10%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>Dr. Jeffrey R. Jay, M.D.,</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>as senior managing member</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1px solid">/s/ Dr. Jeffrey R. Jay, M.D.</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">DR. JEFFREY R. JAY, M.D.</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1px solid">/s/ Mr. David Kroin</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">MR. DAVID KROIN</TD>
    <TD>&nbsp;</TD></TR>
</TABLE>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><U>Exhibit A</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>AGREEMENT REGARDING THE JOINT FILING
OF SCHEDULE 13G</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The undersigned hereby agree as follows:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 36pt">(i)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each
of them is individually eligible to use the Schedule 13G to which this Exhibit is attached, and such Schedule 13G is filed on behalf
of each of them; and</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 36pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 36pt">(ii)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each
of them is responsible for the timely filing of such Schedule 13G and any amendments thereto, and for the completeness and accuracy
of the information concerning such person contained therein; but none of them is responsible for the completeness or accuracy of
the information concerning the other persons making the filing, unless such person knows or has reason to believe that such information
is inaccurate.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 36pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Date: August 13, 2018</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">GREAT POINT PARTNERS, LLC</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman, Times, Serif; width: 49%">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif; width: 1%"><FONT STYLE="font-size: 10pt">By:&nbsp;</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif; width: 40%; border-bottom: Black 1px solid"><FONT STYLE="font-size: 10pt">/s/ Dr. Jeffrey R. Jay, M.D.</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif; width: 10%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">Dr. Jeffrey R. Jay, M.D.,</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">as senior managing member</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman, Times, Serif; border-bottom: Black 1px solid"><FONT STYLE="font-size: 10pt">/s/ Dr. Jeffrey R. Jay, M.D.</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">DR. JEFFREY R. JAY, M.D.</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman, Times, Serif; border-bottom: Black 1px solid"><FONT STYLE="font-size: 10pt">/s/ Mr. David Kroin</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">MR. DAVID KROIN</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</TD></TR>
</TABLE>

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