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    <ACCEPTANCE-DATETIME>20210330165325
    ACCESSION NUMBER:		0001566044-21-000015
    CONFORMED SUBMISSION TYPE:	8-K
    PUBLIC DOCUMENT COUNT:		53
    CONFORMED PERIOD OF REPORT:	20210330
    ITEM INFORMATION:		Regulation FD Disclosure
    ITEM INFORMATION:		Financial Statements and Exhibits
    FILED AS OF DATE:		20210330
    DATE AS OF CHANGE:		20210330

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			VYNE Therapeutics Inc.
    		CENTRAL INDEX KEY:			0001566044
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				453757789
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		8-K
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-38356
    		FILM NUMBER:		21787024

    	BUSINESS ADDRESS:
    		STREET 1:		520 U.S. HIGHWAY 22, SUITE 204
    		CITY:			BRIDGEWATER
    		STATE:			NJ
    		ZIP:			08807
    		BUSINESS PHONE:		800-775-7936

    	MAIL ADDRESS:
    		STREET 1:		520 U.S. HIGHWAY 22, SUITE 204
    		CITY:			BRIDGEWATER
    		STATE:			NJ
    		ZIP:			08807

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	Menlo Therapeutics Inc.
    		DATE OF NAME CHANGE:	20180201

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	Menlo Therapeutics, Inc.
    		DATE OF NAME CHANGE:	20170728

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	Tigercat Pharma, Inc.
    		DATE OF NAME CHANGE:	20130104
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