    <SEC-DOCUMENT>0001104659-21-072479-index.html : 20210526
    <SEC-HEADER>0001104659-21-072479.hdr.sgml : 20210526
    <ACCEPTANCE-DATETIME>20210526170059
    ACCESSION NUMBER:		0001104659-21-072479
    CONFORMED SUBMISSION TYPE:	PRE 14A
    PUBLIC DOCUMENT COUNT:		7
    CONFORMED PERIOD OF REPORT:	20210719
    FILED AS OF DATE:		20210526
    DATE AS OF CHANGE:		20210526

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			VYNE Therapeutics Inc.
    		CENTRAL INDEX KEY:			0001566044
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				453757789
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		PRE 14A
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-38356
    		FILM NUMBER:		21967197

    	BUSINESS ADDRESS:
    		STREET 1:		520 U.S. HIGHWAY 22, SUITE 204
    		CITY:			BRIDGEWATER
    		STATE:			NJ
    		ZIP:			08807
    		BUSINESS PHONE:		800-775-7936

    	MAIL ADDRESS:
    		STREET 1:		520 U.S. HIGHWAY 22, SUITE 204
    		CITY:			BRIDGEWATER
    		STATE:			NJ
    		ZIP:			08807

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	Menlo Therapeutics Inc.
    		DATE OF NAME CHANGE:	20180201

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	Menlo Therapeutics, Inc.
    		DATE OF NAME CHANGE:	20170728

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	Tigercat Pharma, Inc.
    		DATE OF NAME CHANGE:	20130104
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>PRE 14A
    <SEQUENCE>1
    <FILENAME>tm2117172-1_pre14a.htm
    <DESCRIPTION>PRE 14A
    <TEXT>
    Document 1 - file: tm2117172-1_pre14a.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>2
    <FILENAME>lg_vynethera-4c.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 2 - file: lg_vynethera-4c.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>3
    <FILENAME>sg_daviddomzalski-bw.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 3 - file: sg_daviddomzalski-bw.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>4
    <FILENAME>tm2117172d1-pc_proxy14c.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 4 - file: tm2117172d1-pc_proxy14c.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>5
    <FILENAME>tm2117172d1-pc_proxy24c.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 5 - file: tm2117172d1-pc_proxy24c.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>6
    <FILENAME>tm2117172d1-pc_proxy34c.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 6 - file: tm2117172d1-pc_proxy34c.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>7
    <FILENAME>tm2117172d1-pc_proxy44c.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 7 - file: tm2117172d1-pc_proxy44c.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>