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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020
Cash Flows From Operating Activities: |  |
Net Loss | $ (73,329,000) | $ (255,568,000)
Adjustments required to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 109,000 | 341,000
Goodwill and in-process research & development impairments | 0 | 54,345,000
Contingent stock right remeasurement | 0 | 84,726,000
Loss from sale and disposal of fixed assets | 93,000 | 2,101,000
Changes in marketable securities and bank deposits, net | 0 | (142,000)
Debt prepayment premium | 1,432,000 | 0
Share-based compensation | 8,080,000 | 18,100,000
Non-cash other expense (income), net | 2,472,000 | (654,000)
Changes in operating asset and liabilities, net of effects of businesses acquired: |  |
Decrease (increase) in trade receivables, prepaid and other assets | 7,709,000 | (17,138,000)
Decrease (increase) in other non-current assets | 841,000 | (4,171,000)
(Decrease) in accounts payable and accruals | (2,675,000) | (12,975,000)
(Decrease) increase in inventory | 113,000 | (6,048,000)
Decrease (increase) in other liabilities | (1,212,000) | 1,000
Net cash used in operating activities | (56,367,000) | (137,082,000)
Cash Flows From Investing Activities: |  |
Purchase of fixed assets | 0 | (113,000)
Cash acquired through merger | 0 | 38,641,000
Proceeds from sale and maturity of marketable securities and bank deposits | 1,027,000 | 50,579,000
Net cash provided by investing activities | 1,027,000 | 89,107,000
Cash Flows From Financing Activities: |  |
Debt repayment (Note 13) | (36,432,000) | 0
Proceeds from exercise of options and issuance of shares under the employee shares purchase plan | 522,000 | 310,000
Withholding tax from net exercise of restricted share units | (294,000) | (141,000)
Proceeds from issuance of common stock, net of issuance costs | 75,981,000 | 61,639,000
Net cash provided by financing activities | 39,777,000 | 61,808,000
(Decrease) Increase in cash, cash equivalents and restricted cash | (15,563,000) | 13,833,000
Effect of exchange rate on cash, cash equivalents and restricted cash | 0 | 1,000
Cash, cash equivalents and restricted cash at beginning of the year | 58,418,000 | 44,584,000
Cash, cash equivalents and restricted cash at end of the year | 42,855,000 | 58,418,000
Cash and cash equivalents | 42,250,000 | 57,563,000
Restricted cash | 605,000 | 855,000
Total cash, cash equivalents and restricted cash shown in statement of cash flows | 42,855,000 | 58,418,000
Supplementary information on investing and financing activities not involving cash flows: |  |
Issuance of shares under employee share purchase plan | 169,000 | 387,000
Additions to operating lease right of use assets | 0 | 1,350,000
Additions to operating lease liabilities | 0 | 1,350,000
Supplemental disclosure of cash flow information: |  |
Interest received | 17,000 | 102,000
Interest paid | 2,385,000 | 3,941,000
Fair value of assets acquired | 0 | 117,270,000
Less liabilities assumed | 0 | 5,827,000
Net acquired (See “Note 3- Business combination”) | 0 | 111,443,000
Less cash acquired | 0 | 38,641,000
Merger net of cash acquired | $ 0 | $ 72,802,000

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