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v3.22.0.1

NATURE OF OPERATIONS (Details) |  |  |  | 12 Months Ended
--- | --- | --- | --- | ---
Jan. 12, 2022 USD ($) | Aug. 06, 2021 USD ($) | Feb. 12, 2021 shares | Dec. 31, 2021 USD ($) segment employee shares | Dec. 31, 2020 USD ($) shares
Subsequent Event [Line Items] |  |  |  |  |
Number of reportable segments | segment |  |  |  | 1 |
Royalty percent, maximum |  | 10.00% |  |  |
Number of employees terminated | employee |  |  |  | 70 |
Restructuring charges |  |  |  | $ 1,600,000 |
Reverse stock split ratio |  |  | 0.25 |  |
Common stock, shares authorized (in shares) | shares |  |  | 75,000,000 | 150,000,000 | 75,000,000
Net loss |  |  |  | $ 73,329,000 | $ 255,568,000
Cash used in operations |  |  |  | (56,367,000) | $ (137,082,000)
Cash and investments |  |  |  | 42,900,000 |
Licensing Agreements |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |
Payments for licensing agreements |  | $ 1,000,000 |  |  |
Topical BETi Option Agreement |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |
Payments for licensing agreements |  | 500,000 |  |  |
Milestone payments upon achieving certain criteria, maximum |  | 15,750,000 |  |  |
Oral BETi Option Agreement |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |
Payments for licensing agreements |  | 4,000,000 |  |  |
Milestone payments upon achieving certain criteria, maximum |  | $ 43,750,000 |  |  |
Employee benefits |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |
Restructuring charges |  |  |  | 1,400,000 |
Expected cost remaining |  |  |  | 200,000 |
Retention Payments |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |
Restructuring charges |  |  |  | $ 200,000 |
Menlo - Premerger |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |
Common stock, shares authorized (in shares) | shares |  |  | 300,000,000 |  |
Subsequent Event |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |
Upfront payment | $ 20,000,000 |  |  |  |
Additional consideration receivable | $ 5,000,000 |  |  |  |
Period of closing transaction | 1 year |  |  |  |
Milestone payments receivable upon achievement of net sales | $ 450,000,000 |  |  |  |
Milestone payments upon achieving certain criteria, exceeding annual net sales | $ 100,000,000 |  |  |  |

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