Cash includes currency on hand as well as demand deposits with banks or financial institutions. It also includes other kinds of accounts that have the general characteristics of demand deposits in that the customer may deposit additional funds at any time and effectively may withdraw funds at any time without prior notice or penalty. Cash equivalents, excluding items classified as marketable securities, include short-term, highly liquid Investments that are both readily convertible to known amounts of cash, and so near their maturity that they present minimal risk of changes in value because of changes in interest rates. Generally, only investments with original maturities of three months or less qualify under that definition. Original maturity means original maturity to the entity holding the investment. For example, both a three-month US Treasury bill and a three-year Treasury note purchased three months from maturity qualify as cash equivalents. However, a Treasury note purchased three years ago does not become a cash equivalent when its remaining maturity is three months. Short-term investments, exclusive of cash equivalents, generally consist of marketable securities intended to be sold within one year (or the normal operating cycle if longer) and may include trading securities, available-for-sale securities, or held-to-maturity securities (if maturing within one year), as applicable.

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 210
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.5-02.1)
-URI http://asc.fasb.org/extlink&oid=120391452&loc=d3e13212-122682

NATURE OF OPERATIONS (Details)				12 Months Ended
NATURE OF OPERATIONS (Details)	Jan. 12, 2022 USD ($)	Aug. 06, 2021 USD ($)	Feb. 12, 2021 shares	Dec. 31, 2021 USD ($) segment employee shares	Dec. 31, 2020 USD ($) shares
Subsequent Event [Line Items]
Number of reportable segments \| segment				1
Royalty percent, maximum		10.00%
Number of employees terminated \| employee				70
Restructuring charges				$ 1,600,000
Reverse stock split ratio			0.25
Common stock, shares authorized (in shares) \| shares			75,000,000	150,000,000	75,000,000
Net loss				$ 73,329,000	$ 255,568,000
Cash used in operations				(56,367,000)	$ (137,082,000)
Cash and investments				42,900,000
Licensing Agreements
Subsequent Event [Line Items]
Payments for licensing agreements		$ 1,000,000
Topical BETi Option Agreement
Subsequent Event [Line Items]
Payments for licensing agreements		500,000
Milestone payments upon achieving certain criteria, maximum		15,750,000
Oral BETi Option Agreement
Subsequent Event [Line Items]
Payments for licensing agreements		4,000,000
Milestone payments upon achieving certain criteria, maximum		$ 43,750,000
Employee benefits
Subsequent Event [Line Items]
Restructuring charges				1,400,000
Expected cost remaining				200,000
Retention Payments
Subsequent Event [Line Items]
Restructuring charges				$ 200,000
Menlo - Premerger
Subsequent Event [Line Items]
Common stock, shares authorized (in shares) \| shares			300,000,000
Subsequent Event
Subsequent Event [Line Items]
Upfront payment	$ 20,000,000
Additional consideration receivable	$ 5,000,000
Period of closing transaction	1 year
Milestone payments receivable upon achievement of net sales	$ 450,000,000
Milestone payments upon achieving certain criteria, exceeding annual net sales	$ 100,000,000