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NATURE OF OPERATIONS (Details) £ in Thousands						3 Months Ended		9 Months Ended		12 Months Ended
	Mar. 31, 2022 USD ($)	Mar. 15, 2022 USD ($)	Jan. 12, 2022 USD ($)	Aug. 06, 2021 USD ($)	Feb. 12, 2021 shares	Sep. 30, 2022 USD ($) shares	Sep. 30, 2021 USD ($)	Sep. 30, 2022 USD ($) segment shares	Sep. 30, 2021 USD ($)	Dec. 31, 2021 USD ($) employee shares	Jun. 28, 2022 USD ($)	Jun. 28, 2022 GBP (£)	Jun. 15, 2022 USD ($)	Jun. 15, 2022 GBP (£)	Feb. 11, 2021 shares	Dec. 31, 2020 USD ($)
Deferred Compensation Arrangement with Individual, Share-based Payments [Line Items]
Number of segments | segment								1
Additional paid-in capital						$ 692,853,000		$ 692,853,000		$ 688,156,000
Period of closing transaction			1 year
Disposal group, milestone payments receivable upon achievement of net sales			$ 450,000,000
Milestone payments upon achieving certain criteria, exceeding annual net sales			$ 100,000,000
Restructuring and related cost, number of positions eliminated | employee										28
Reverse stock split, conversion ratio (share/share)					0.25
Common stock shares authorized (in shares) | shares					75,000,000	150,000,000		150,000,000		150,000,000
Net loss						$ (9,459,000)	$ (21,285,000)	$ (13,265,000)	$ (61,759,000)
Cash used in operations								(25,325,000)	(46,349,000)
(Loss) income from discontinued operations, net of income taxes						(204,000)	(7,009,000)	12,919,000	(25,923,000)
Net loss						(9,255,000)	(14,276,000)	(26,184,000)	(35,836,000)
Cash and cash equivalents, and restricted cash						35,577,000	$ 52,911,000	35,577,000	$ 52,911,000	$ 42,855,000						$ 58,418,000
Accumulated deficit						(652,790,000)		(652,790,000)		$ (639,525,000)
Outstanding debt						0		0
Sale of stock, public float threshold						75,000,000		75,000,000
Lincoln Park Equity Purchase Agreement
Deferred Compensation Arrangement with Individual, Share-based Payments [Line Items]
Consideration receivable on transaction	$ 30,000,000	$ 30,000,000
Term of equity purchase agreement	36 months	36 months
Menlo - Premerger
Deferred Compensation Arrangement with Individual, Share-based Payments [Line Items]
Common stock shares authorized (in shares) | shares															300,000,000
MST Franchise | Discontinued Operations, Disposed of by Sale
Deferred Compensation Arrangement with Individual, Share-based Payments [Line Items]
Cash proceeds						20,000,000		20,000,000
Additional paid-in capital						$ 5,000,000		$ 5,000,000
Licensing Agreements
Deferred Compensation Arrangement with Individual, Share-based Payments [Line Items]
Payments for licensing agreements				$ 1,000,000
Royalty percent, maximum				10.00%
Topical BETi Option Agreement
Deferred Compensation Arrangement with Individual, Share-based Payments [Line Items]
Payments for licensing agreements				$ 500,000
Milestone payments upon achieving certain criteria, maximum				$ 15,750,000
Royalty payments as percentage of annual net sales of licensed product (percent)				10.00%
Oral BETi Option Agreement
Deferred Compensation Arrangement with Individual, Share-based Payments [Line Items]
Payments for licensing agreements				$ 4,000,000
Milestone payments upon achieving certain criteria, maximum				$ 43,750,000
First payments for licensing agreements											$ 386,366	£ 300
Second payment for licensing agreements													$ 997,407	£ 850

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