    <SEC-DOCUMENT>0001104659-22-122067-index.html : 20221125
    <SEC-HEADER>0001104659-22-122067.hdr.sgml : 20221125
    <ACCEPTANCE-DATETIME>20221125140010
    ACCESSION NUMBER:		0001104659-22-122067
    CONFORMED SUBMISSION TYPE:	DEF 14A
    PUBLIC DOCUMENT COUNT:		5
    CONFORMED PERIOD OF REPORT:	20230112
    FILED AS OF DATE:		20221125
    DATE AS OF CHANGE:		20221125

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			VYNE Therapeutics Inc.
    		CENTRAL INDEX KEY:			0001566044
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				453757789
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		DEF 14A
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-38356
    		FILM NUMBER:		221419698

    	BUSINESS ADDRESS:
    		STREET 1:		685 ROUTE 202/206, SUITE 301A
    		CITY:			BRIDGEWATER
    		STATE:			NJ
    		ZIP:			08807
    		BUSINESS PHONE:		800-775-7936

    	MAIL ADDRESS:
    		STREET 1:		685 ROUTE 202/206, SUITE 301A
    		CITY:			BRIDGEWATER
    		STATE:			NJ
    		ZIP:			08807

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	Menlo Therapeutics Inc.
    		DATE OF NAME CHANGE:	20180201

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	Menlo Therapeutics, Inc.
    		DATE OF NAME CHANGE:	20170728

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	Tigercat Pharma, Inc.
    		DATE OF NAME CHANGE:	20130104
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>DEF 14A
    <SEQUENCE>1
    <FILENAME>tm2230379-2_def14a.htm
    <DESCRIPTION>DEF 14A
    <TEXT>
    Document 1 - file: tm2230379-2_def14a.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>2
    <FILENAME>lg_vyne-4c.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 2 - file: lg_vyne-4c.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>3
    <FILENAME>sg_daviddomzalskinew01-bw.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 3 - file: sg_daviddomzalskinew01-bw.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>4
    <FILENAME>tm2230379d2-px_01pagebw.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 4 - file: tm2230379d2-px_01pagebw.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>5
    <FILENAME>tm2230379d2-px_02pagebw.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 5 - file: tm2230379d2-px_02pagebw.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>