<SEC-DOCUMENT>0001104659-22-122067-index.html : 20221125
<SEC-HEADER>0001104659-22-122067.hdr.sgml : 20221125
<ACCEPTANCE-DATETIME>20221125140010
ACCESSION NUMBER:		0001104659-22-122067
CONFORMED SUBMISSION TYPE:	DEF 14A
PUBLIC DOCUMENT COUNT:		5
CONFORMED PERIOD OF REPORT:	20230112
FILED AS OF DATE:		20221125
DATE AS OF CHANGE:		20221125

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			VYNE Therapeutics Inc.
		CENTRAL INDEX KEY:			0001566044
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				453757789
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		DEF 14A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-38356
		FILM NUMBER:		221419698

	BUSINESS ADDRESS:	
		STREET 1:		685 ROUTE 202/206, SUITE 301A
		CITY:			BRIDGEWATER
		STATE:			NJ
		ZIP:			08807
		BUSINESS PHONE:		800-775-7936

	MAIL ADDRESS:	
		STREET 1:		685 ROUTE 202/206, SUITE 301A
		CITY:			BRIDGEWATER
		STATE:			NJ
		ZIP:			08807

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Menlo Therapeutics Inc.
		DATE OF NAME CHANGE:	20180201

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Menlo Therapeutics, Inc.
		DATE OF NAME CHANGE:	20170728

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Tigercat Pharma, Inc.
		DATE OF NAME CHANGE:	20130104
</SEC-HEADER>
<DOCUMENT>
<TYPE>DEF 14A
<SEQUENCE>1
<FILENAME>tm2230379-2_def14a.htm
<DESCRIPTION>DEF 14A
<TEXT>
Document 1 - file: tm2230379-2_def14a.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>2
<FILENAME>lg_vyne-4c.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 2 - file: lg_vyne-4c.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>3
<FILENAME>sg_daviddomzalskinew01-bw.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 3 - file: sg_daviddomzalskinew01-bw.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>4
<FILENAME>tm2230379d2-px_01pagebw.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 4 - file: tm2230379d2-px_01pagebw.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>5
<FILENAME>tm2230379d2-px_02pagebw.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 5 - file: tm2230379d2-px_02pagebw.jpg

</DOCUMENT>
</SEC-DOCUMENT>