<SEC-DOCUMENT>0001104659-23-117288-index.html : 20231113
<SEC-HEADER>0001104659-23-117288.hdr.sgml : 20231113
<ACCEPTANCE-DATETIME>20231113164109
ACCESSION NUMBER:		0001104659-23-117288
CONFORMED SUBMISSION TYPE:	SC 13G
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20231113
DATE AS OF CHANGE:		20231113
GROUP MEMBERS:		CITADEL ADVISORS HOLDINGS LP
GROUP MEMBERS:		CITADEL GP LLC
GROUP MEMBERS:		CITADEL SECURITIES GP LLC
GROUP MEMBERS:		CITADEL SECURITIES GROUP LP
GROUP MEMBERS:		CITADEL SECURITIES LLC
GROUP MEMBERS:		KENNETH GRIFFIN

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			VYNE Therapeutics Inc.
		CENTRAL INDEX KEY:			0001566044
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				453757789
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-90268
		FILM NUMBER:		231399544

	BUSINESS ADDRESS:	
		STREET 1:		685 ROUTE 202/206 N., SUITE 301
		CITY:			BRIDGEWATER
		STATE:			NJ
		ZIP:			08807
		BUSINESS PHONE:		800-775-7936

	MAIL ADDRESS:	
		STREET 1:		685 ROUTE 202/206 N., SUITE 301
		CITY:			BRIDGEWATER
		STATE:			NJ
		ZIP:			08807

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Menlo Therapeutics Inc.
		DATE OF NAME CHANGE:	20180201

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Menlo Therapeutics, Inc.
		DATE OF NAME CHANGE:	20170728

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Tigercat Pharma, Inc.
		DATE OF NAME CHANGE:	20130104

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			CITADEL ADVISORS LLC
		CENTRAL INDEX KEY:			0001423053
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G

	BUSINESS ADDRESS:	
		STREET 1:		SOUTHEAST FINANCIAL CENTER
		STREET 2:		200 S. BISCAYNE BLVD., SUITE 3300
		CITY:			MIAMI
		STATE:			FL
		ZIP:			33131
		BUSINESS PHONE:		305-929-6851

	MAIL ADDRESS:	
		STREET 1:		SOUTHEAST FINANCIAL CENTER
		STREET 2:		200 S. BISCAYNE BLVD., SUITE 3300
		CITY:			MIAMI
		STATE:			FL
		ZIP:			33131
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G
<SEQUENCE>1
<FILENAME>tm2330557d1_sc13g.htm
<DESCRIPTION>SC 13G
<TEXT>
Document 1 - file: tm2330557d1_sc13g.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>2
<FILENAME>tm2330557d1_ex99-1.htm
<DESCRIPTION>EXHIBIT 99.1
<TEXT>
Document 2 - file: tm2330557d1_ex99-1.htm

</DOCUMENT>
</SEC-DOCUMENT>